CN103285512A - Electric brain stimulator based on serial port output digital trigger signals and implementation method thereof - Google Patents
Electric brain stimulator based on serial port output digital trigger signals and implementation method thereof Download PDFInfo
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- CN103285512A CN103285512A CN201310229835XA CN201310229835A CN103285512A CN 103285512 A CN103285512 A CN 103285512A CN 201310229835X A CN201310229835X A CN 201310229835XA CN 201310229835 A CN201310229835 A CN 201310229835A CN 103285512 A CN103285512 A CN 103285512A
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Abstract
The invention discloses an electric brain stimulator based on a serial port and an implementation method thereof and belongs to the field of medical equipment. The electric brain stimulator based on the serial port comprises an electric brain stimulation control section and a communication device, wherein the electric brain stimulation control section comprises a designer and a player; the designer is a tool for designing processes of the electric brain stimulation control section and provides processes for a user to voluntarily design the electric brain stimulation control section; the player serves as a computer display tool of the electric brain stimulator and is used for playing pictures, sound stimulation and the like; and the communication device serves as a tool for communication interaction of a computer and an electroencephalograph (electroencephalogram acquisition system) and is used for the computer to send digital trigger signals synchronous with stimulation to the electroencephalograph.
Description
Technical field
The present invention relates to technical field of medical instruments, relate in particular to event related potential and detect relevant EBS.
Background technology
In recent years, along with advancing by leaps and bounds of cognitive neuroscience research, ERP is subjected to brain science circle especially and pays close attention to more widely.The ERP(event related potential) refers to every a kind of specific stimulation that adds, act on a certain position of sensory system or brain, when stimulating or cancel stimulation, in the caused potential change in brain district.At present, brain electricity ERP stimulator adopts the parallel port output numeral of computer to trigger (trigger) signal usually, such as Eprime and STIM2 stimulating system.It is the programmable EBS software of a cover that STIM 2 stimulates generation system, is provided with compensation by Neuroscan company.In addition, in the research of brain-computer interface, when needing stimulus signal such as vision, audition or body sense, also need stimulator to produce corresponding the stimulation, stimulating output simultaneously and stimulating synchronous digital trigger signal, the stimulator of present brain-computer interface is the computer parallel port output triggering signals that adopt also more.But the especially most no parallel port configurations of notebook of present computer, the computer standard configuration only provides RS232 serial ports or USB interface.Therefore, adopt the ERP stimulator of computer parallel port output in use selecting computer to be restricted, use inconvenience.
The major function of existing EBS provides stimulations such as audition, vision, realizes the broadcast that picture, sound etc. stimulate, and sends triggering signal with the parallel data transmission manner to electroencephalograph when playing.Triggering signal with play object do not have related, but most the no parallel ports configurations of present computer, computer standard disposes only provides RS232 serial ports or USB interface.
Hu Jianfeng, Yin Jinghai, Mu Zhendong etc. are in July, 2007 Xinyang normal university journal: the 20th the 3rd phase of volume of natural science edition is delivered " based on the development of the brain-computer interface stimulating system of brain electricity ".A kind of design of EBS has been described in the literary composition.But transfer of data still adopts parallel interface, and it is not enough with the circulation degree of association to play object, does not realize triggering synchronously, makes that the EBS effect of stimulation is undesirable, is selecting on the computer same the existence to limit.
Summary of the invention
The present invention is directed to the above-mentioned deficiency of present EBS, a kind of EBS based on the synchronous triggered digital signal of serial ports output stimulation is provided.
The technical scheme that the present invention solves the problems of the technologies described above is: provide a kind of EBS based on serial ports output triggering signal to comprise electrical brain stimulation control section and serial communication device.The electrical brain stimulation control section comprises designer, player, adopts the .net pattern.Designer provides user to design the flow process of EBS control section voluntarily as the instrument of design EBS control section flow process.User can by designer finish design electrical brain stimulation experiment flow process, select mode (as stimulations such as sound, picture, literal), the order that electrical brain stimulation is set and the various stimulations of electrical brain stimulation presentative time, operation such as triggering signal is set.Player is used for computer and plays corresponding electrical brain stimulation (as stimulations such as sound, picture, literal) according to the electrical brain stimulation flow process of design as the computer show tools of EBS, and is playing the triggering signal that arranges to the USB interface transmission simultaneously.
Concrete technical scheme is: a kind of EBS based on serial ports output triggering signal, comprise, electrical brain stimulation control section, serial communication device, the electrical brain stimulation control section comprises designer, player, designer design EBS control section flow process, add picture, sound, literal, and send digital trigger signal when editing order that their play, reproduction time, broadcast, send to player; Player is used for playing picture, sound, literal stimulus signal according to triggering signal control as the display control section of EBS; The serial communication device is realized the communication interaction of computer and EBS, be used for computer and receive the electrical brain stimulation signal, and receiving computer is to the digital trigger signal synchronous with the electrical brain stimulation signal of EBS acquisition system transmission.
Designer provides one to play object class control unit and a circulation class control unit in the electrical brain stimulation control section, plays file type, reproduction time, file address, the triggering signal coding of object class control unit control player; Cycle-index, the circulation object of circulation class control unit control player; Designer design EBS control section flow process specifically comprises: according to triggering signal editor electrical brain stimulation scheme, increase cycle-index, the circulation object of player, and the broadcast object in the same circulation object arranged with queue structure, and the circulation object properties are set.Described serial communication device specifically comprises: USB modular converter, single-chip microcomputer functional module, parallel port output module; The digital trigger signal synchronous with electrical brain stimulation that the USB transmitting-receiving FPDP receiving computer USB port of USB modular converter sends, the USB modular converter is processed into serial signal with the triggering signal that receives, be sent to the serial data receiving terminal of single-chip microcomputer functional module by its serial ports transmit port, the single-chip microcomputer functional module is encoded to the serial data that receives, convert 82 system parallel datas to, the single-chip microcomputer functional module exports this parallel data to the latches of parallel port output module, latch output parallel data is to the parallel port female of parallel port output module, and the parallel port female is connected with the digital trigger signal input interface of EBS by the parallel interface line.The USB modular converter comprises PL2303USB conversion chip, electric source filter circuit and USB interface, and electric source filter circuit is made of capacitances in series; Triggering signal is undertaken alternately by data transmit-receive port and the computer of USB interface, and data transmit-receive port and single-chip microcomputer by the PL2303USB conversion chip carry out alternately, and the parallel port output module adopts chip 74573.Player reads the cycle-index of all circulations, repeat to travel through the interior circulation object of circulation according to cycle-index, control PictureBox or Windows Media Player at broadcast interface plays the circulation object elements simultaneously, and player is play when stimulating element at every turn can send digital trigger signal to communicator by the serialPort control.
The serial communication device comprises: with PL2303 be core USB modular converter (A), be the functional module (B) of core, be parallel port output module (C) and the USB power supply circuit (D) of core with 74573 with single-chip microcomputer (8052).The input of serial communication device is connected with the computer USB interface by the USB modular converter, and outfan is connected with electroencephalograph by holding circuit and the parallel port female of parallel port output module, is connected as triggering input with the numeral of Neuroscan electroencephalograph.Provide power supply by the USB power supply module.The USB modular converter comprises PL2303USB connect chip, electric source filter circuit and USB interface, and electric source filter circuit is made of capacitor C 08, CJ2 series connection; Triggering signal is undertaken alternately by the data transmit-receive port (D1, D2 mouth) of USB interface and computer, is undertaken alternately by data transmit-receive port (D10, D11 mouth) and the single-chip microcomputer of PL2303.
The present invention also proposes a kind of EBS implementation method based on serial ports output triggering signal, designer design EBS control section flow process in the electrical brain stimulation control section, add picture, sound, literal, and send digital trigger signal when editing order that their play, reproduction time, broadcast, send to player; Player is used for playing picture, sound, literal stimulus signal according to triggering signal control as the display control section of EBS; The serial communication device is realized the communication interaction of computer and EBS, be used for computer and receive the electrical brain stimulation signal, and receiving computer is to the digital trigger signal synchronous with the electrical brain stimulation signal of EBS acquisition system transmission
Designer provides one to play object class and a circulation class.The attribute of playing object class comprises file type, reproduction time, file address, triggering signal coding etc.; The attribute of circulation class comprises cycle-index, circulation object etc.Designer design EBS control section flow process, editor's electrical brain stimulation scheme is play object and circulation object by increasing, and it is related with the circulation class to play object, its correlating method is that the broadcast object in the same circulation is arranged with the data structure of formation, and the circulation object properties that are set to circulate.Player reads the cycle-index of all circulations, repeat to travel through the interior circulation object of circulation according to cycle-index, the picture at broadcast interface shows control PictureBox or sound play control (such as Windows Media Player) broadcast circulation object elements simultaneously under the control of triggering signal.Player reads the cycle-index of all circulations, repeat to travel through the interior circulation object of circulation according to cycle-index, the picture at broadcast interface shows control PictureBox or sound play control (such as Windows Media Player) broadcast circulation object elements simultaneously.Player can send digital trigger signal to communicator by serial ports serialPort control when playing the circulation object elements.
EBS based on serial ports output triggering signal provided by the invention, by adopting the communication device of serial input and line output, be used for providing synchronous triggering control signal in the broadcast obj ect file between EBS and the computer, can effectively improve the effect of stimulation and the accuracy rate of reception signal, and in the communication interaction of computer and electroencephalograph, be convenient to select for use the general calculation machine to realize EBS.
Description of drawings
Fig. 1 is the structured flowchart of integral body of the present invention;
Fig. 2 is the structured flowchart of communicator of the present invention;
Fig. 3 is the flow chart of EBS control section operation designer of the present invention;
Fig. 4 is the flow chart of EBS control section operation player of the present invention.
Fig. 5 is the structure connection layout of EBS serial communication device of the present invention.
The specific embodiment
Fig. 1 is the structured flowchart of integral body of the present invention.Referring to Fig. 1, EBS of the present invention mainly comprises: electrical brain stimulation control section and communicator that designer and player are formed.Designer provides the flow process of user design EBS control section as the instrument of design EBS control section flow process; Player is as the computer show tools of EBS, for the picture of playing the user needs, sonic stimulation etc.The serial communication device is used for computer and sends the digital trigger signal synchronous with stimulation to electroencephalograph as the instrument of computer and electroencephalograph (as the Neuroscan electroencephalograph) communication interaction.
Fig. 2 comprises for serial communication device of the present invention: with PL2303 be core USB modular converter (A), be the functional module (B) of core, be parallel port output module (C) and the USB power supply circuit (D) of core with 74573 with single-chip microcomputer (8052).The input of serial communication device is connected with the computer USB interface by the PL2303 conversion chip, and outfan is connected with the numeral triggering input port of electroencephalograph by holding circuit and the parallel port female of parallel port output module
Fig. 3 is the program flow diagram of EBS control section designer of the present invention.The program circuit of EBS control section designer is as shown in the figure:
1. set up a formation of depositing circulation earlier;
2. detect in the electrical brain stimulation program that needs design whether will add cyclic node, if there is cyclic node to need to add, then in round-robin queue, add a cyclic node;
3. detect in the cyclic node whether will add node element, if there is element to need to add, then add node element;
4. if the node element that will not add in the cyclic node then repeats the operation in the 2nd step;
5. if the cyclic node that will not add in the circulation then finishes to design program.
Fig. 4 is the program flow diagram of EBS control section player of the present invention.The program circuit of EBS control section player is as shown in the figure:
1. read the formation of a circulation earlier;
2. detect whether cyclic node is arranged in the round-robin queue, if cyclic node is arranged, then read cyclic node in the round-robin queue;
3. detect whether node element is arranged in the cyclic node, if there is element to need to add, then play node element;
4. if do not have node element in the cyclic node, then repeat the operation in the 2nd step;
5. if do not have cyclic node in the circulation, then finish playing program.
The function that provides in the .net graphics process class libraries is provided EBS control section player plays image of the present invention, is held in to move under Windows XP and the highest version system environments thereof.
In EBS control section player of the present invention, each node element comprises multiple attribute, as triggering signal, reproduction time etc.
The effect of digital trigger signal attribute is to play node element to begin computer-chronograph and will by the EBS serial communication device triggering signal attribute be sent to electroencephalograph with the form of serial data at every turn.
EBS control section transmission serial triggering signal .net adopts the serial ports class libraries to be supported in and moves under Windows XP and the highest version system environments thereof.
The effect of serial communication device is to accept the triggering signal (serial data) that computer sends, and sends to electroencephalograph through being processed into parallel signal.
The input of serial communication device is connected with the computer USB interface by the USB change-over circuit, and outfan is connected with the input of the digital trigger signal of electroencephalograph by 74573 holding circuits and parallel port female.Integrated circuit provides power supply by the USB power supply module.
Fig. 5 is the structure connection layout of serial communication device.
The serial communication device comprises: with PL2303 be core the USB modular converter, be the functional module of core, be parallel port output module and the USB power supply circuit of core with 74573 with single-chip microcomputer (8052).
The USB change-over circuit links to each other with computer, and computer sends triggering signal to the USB transmitting-receiving FPDP of USB modular converter by the data transmit-receive mouth of USB modular converter; The USB modular converter becomes serial signal with the date processing that receives, and is sent to the serial data receiving terminal of functional module single-chip microcomputer by its serial ports transmit port; Single-chip microcomputer is encoded to it after receiving serial data, converts thereof into 82 system parallel datas, exports latch 74HC573 input to by single-chip microcomputer parallel output terminal mouth 1 and latchs, and then exports the parallel port female to by the latch outfan; The parallel port female is connected with the digital trigger signal interface of electroencephalograph.Below just finished the communication function of computer and electroencephalograph.
The USB modular converter comprises PL2303USB connect chip, electric source filter circuit and USB interface, and electric source filter circuit is made of capacitor C 08, CJ2 series connection; Triggering signal is undertaken alternately by the data transmit-receive port (D1, D2) of USB interface and computer, is undertaken alternately by data transmit-receive port (D10, D11) and the single-chip microcomputer of PL2303USB connect chip.
The effect of reproduction time attribute is be used to the time of stipulating that each element is play.Because this is for electrical brain stimulation, therefore need accurate timing.Therefore the electrical brain stimulation control section also comprises intervalometer.Intervalometer uses QueryPerformanceFrequency () and QueryPerformanceCounter () function.These two functions are precise time functions that VC provides, before carrying out timing, call the clock frequency that QueryPerformanceFrequency () function obtains the machine intimate intervalometer earlier, before playing the generation of stimulus file event and after taking place, call QueryPerformanceCounter () function respectively then, utilize difference and the clock frequency of the counting of twice acquisition, the precise time that the event of calculating experiences.
Claims (10)
1. EBS based on serial ports output triggering signal, comprise, electrical brain stimulation control section, serial communication device, it is characterized in that, the electrical brain stimulation control section comprises designer, player, and designer design EBS control section flow process is added picture, sound, literal, and send digital trigger signal when editing order that their play, reproduction time, broadcast, send to player; Player is used for controlling synchronous playing pictures, sound, literal stimulus signal according to triggering signal as the display control section of EBS; The serial communication device is realized the communication interaction of computer and EBS, be used for computer and receive the electrical brain stimulation signal, and receiving computer is to the digital trigger signal synchronous with the electrical brain stimulation signal of EBS acquisition system transmission.
2. EBS according to claim 1, it is characterized in that, designer provides one to play object class control unit and a circulation class control unit in the electrical brain stimulation control section, plays file type, reproduction time, file address, the triggering signal coding of object class control unit control player; Cycle-index, the circulation object of circulation class control unit control player; Designer design EBS control section flow process specifically comprises: according to triggering signal editor electrical brain stimulation scheme, increase cycle-index, the circulation object of player, and the broadcast object in the same circulation object arranged with queue structure, and the circulation object properties are set.
3. EBS according to claim 1 is characterized in that, described serial communication device specifically comprises: USB modular converter, single-chip microcomputer functional module, parallel port output module; The digital trigger signal synchronous with electrical brain stimulation that the USB transmitting-receiving FPDP receiving computer USB port of USB modular converter sends, the USB modular converter is processed into serial signal with the triggering signal that receives, be sent to the serial data receiving terminal of single-chip microcomputer functional module by its serial ports transmit port, the single-chip microcomputer functional module is encoded to the serial data that receives, convert 82 system parallel datas to, the single-chip microcomputer functional module exports this parallel data to the latches of parallel port output module, latch output parallel data is to the parallel port female of parallel port output module, and the parallel port female is connected with the digital trigger signal input interface of electroencephalograph by the parallel interface line.
4. EBS according to claim 3 is characterized in that, the USB modular converter comprises PL2303USB conversion chip, electric source filter circuit and USB interface, and electric source filter circuit is made of capacitances in series; Triggering signal is undertaken alternately by data transmit-receive port and the computer of USB interface, and data transmit-receive port and single-chip microcomputer by the PL2303USB conversion chip carry out alternately.
5. EBS according to claim 2, it is characterized in that, player reads the cycle-index of all circulations, repeat to travel through the interior circulation object of circulation according to cycle-index, control PictureBox or Windows Media Player at broadcast interface plays the circulation object elements simultaneously, and player is play when stimulating element at every turn can send digital trigger signal to communicator by the serialPort control.
6. EBS implementation method based on serial ports output triggering signal, it is characterized in that, designer design EBS control section flow process in the electrical brain stimulation control section, add picture, sound, literal, and send digital trigger signal when editing order that their play, reproduction time, broadcast, send to player; Player is used for playing synchronously picture, sound, literal stimulus signal according to triggering signal control as the display control section of EBS; The serial communication device is realized the communication interaction of computer and EBS, be used for computer and receive the electrical brain stimulation signal, and receiving computer is to the digital trigger signal synchronous with the electrical brain stimulation signal of EBS acquisition system transmission.
7. method according to claim 6, it is characterized in that, designer provides one to play object class control unit and a circulation class control unit in the electrical brain stimulation control section, plays file type, reproduction time, file address, the triggering signal coding of object class control unit control player; Cycle-index, the circulation object of circulation class control unit control player; Designer design EBS control section flow process specifically comprises: according to triggering signal editor electrical brain stimulation scheme, increase cycle-index, the circulation object of player, and the broadcast object in the same circulation object arranged with queue structure, and the circulation object properties are set.
8. method according to claim 6, it is characterized in that, the serial communication device comprises with the PL2303USB conversion chip and is the USB modular converter of core, is the functional module of core with the single-chip microcomputer, is parallel port output module, the USB power supply circuit of core with chip 74573, the input of serial communication device is connected with the computer USB interface by the PL2303 conversion chip, and outfan is connected with electroencephalograph by holding circuit and the parallel port female of parallel port output module.
9. method according to claim 7, it is characterized in that, player reads the cycle-index of all circulations, repeats to travel through the interior circulation object of circulation according to cycle-index, and control unit PictureBox or the Windows Media Player at broadcast interface plays the circulation object elements simultaneously.
10. method according to claim 8, it is characterized in that, the USB modular converter comprises PL2303USB connect chip, electric source filter circuit and USB interface, electric source filter circuit is made of capacitances in series, triggering signal is undertaken alternately by data transmit-receive port and the computer of USB interface, is undertaken alternately by data transmit-receive port and the single-chip microcomputer of PL2303USB connect chip.
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Cited By (3)
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| CN110548233A (en) * | 2019-09-30 | 2019-12-10 | 上海交通大学 | Portable double-channel transcranial ultrasonic stimulation device for nerve regulation |
| CN113069107A (en) * | 2021-03-22 | 2021-07-06 | 复旦大学附属眼耳鼻喉科医院 | Auditory function test equipment, wearable equipment and auditory function test system |
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| CN113069107A (en) * | 2021-03-22 | 2021-07-06 | 复旦大学附属眼耳鼻喉科医院 | Auditory function test equipment, wearable equipment and auditory function test system |
| CN113069107B (en) * | 2021-03-22 | 2024-03-19 | 复旦大学附属眼耳鼻喉科医院 | Auditory function test device, wearable device and auditory function test system |
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