CN102370673A - Subing (quick effect heart rescue) spraying agent and its preparation method - Google Patents
Subing (quick effect heart rescue) spraying agent and its preparation method Download PDFInfo
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- CN102370673A CN102370673A CN2010102597358A CN201010259735A CN102370673A CN 102370673 A CN102370673 A CN 102370673A CN 2010102597358 A CN2010102597358 A CN 2010102597358A CN 201010259735 A CN201010259735 A CN 201010259735A CN 102370673 A CN102370673 A CN 102370673A
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Abstract
The invention provides a novel traditional Chinese medicinal compound Subing (quick effect heart rescue) spraying agent and its preparation method and belongs to the field of biomedicine, wherein the Subing (quick effect heart rescue) spraying agent has a good curative effect of resisting coronary angina pectoris. The problem of dissolving borneol with levant storax oil is solved by a new technology and a new method. The prescription is composed of styrax, borneol, a solubiliser, an absorption enhancer and a solvent. By the simple new technology of dissolution, homogenization and the like, borneol which is completely insoluble in water and levant storax oil which is not miscible with water phase are dissolved together in an oral water-soluble base so as to obtain an oral solution which is uniform and transparent without layers and suspension. The spraying agent or aerosol prepared in the invention can be quantitatively and directly sprayed into mouth or sprayed under tongue or directly sprayed into nasal cavity. In comparison with a solid preparation, the spraying agent prepared by styrax and borneol for oral administration has advantages of fast absorption and rapid effect, can perform a curative effect better and faster, is applicable to be taken by patients with angina pectoris during the acute phase. By the adoption of the preparation method provided by the invention, the effect onset time is greatly shortened within 60 seconds. The preparation method provides a good therapeutic novel medicine for currently high frequency and high occurrence of heart disease in our country.
Description
Technical field
The present invention relates to a kind of herbal mixture Su Bing (fast-acting heart disease curing) spray of preventing and treating angina pectoris etc. and preparation method thereof, belong to biomedicine field.
Background technology
Styrax is the balsam that the trunk of Hamamelidaceae plant Styrax tree Liquidambar orientalis Mill. oozes out, and forms through processing and refining.Character is semimobile dense thick liquid, and pale brown color or burgundy are translucent, the matter thickness.Gas fragrance.Function with cure mainly to having one's ideas straightened out, broken dirty, pain relieving.Be used for the apoplexy syncope due to accumulation of phlegm, the soldier so faints breast abdomen cold type of pain, infantile convulsion, warm disease.Borneolum Syntheticum is the process of resin article of Dipterocarpaceae aiphyllium plant Borneolum Syntheticum Dryobalanops aromati-ca Gaertn.f.; Or use Camphora, Lignum Pini Nodi wet goods to be raw material; Through the synthetic goods of chemical method, or the crystallization of extracting by the leaf of Compositae herbaceos perennial Herba Blumeae Balsamiferae (Balsamiferou Blumea Herb) Blumeabalsam-ifere DC..Function is the refreshment of having one's ideas straightened out, clearing away heat to alleviate pain, anti-inflammatory anti-itch; Be used for the calentura coma, convulsion is fainted, apoplexy is light faints, and loses consciousness, and loses consciousness, attacked by pestiferous factors dusk falls forward, aphtha, laryngopharynx swelling and pain, conjunctival congestion, auditory meatus stream is dense, diseases such as sore swollen toxin.The compound preparation of the two is a Subing drop pills, in about the eighties in 20th century, in China's listing, about 2000, stops production.Function with cure mainly to removing obstruction, smoothing circulation and stopping pains..Be used for uncomfortable in chest, angina pectoris, myocardial infarction etc. and coronary heart disease, have above-mentioned symptom, rapidly relief of symptoms.Through retrieval, there be not prescription and the preparation technology and the clinical practice report of Su Bing (fast-acting heart disease curing) spray.
Summary of the invention
The purpose of this invention is to provide a kind of antianginal spray of processing by Styrax and Borneolum Syntheticum and preparation method thereof, make it to have the effect of alleviating uncomfortable in chest, angina pectoris, myocardial infarction and coronary heart disease.This product preparation process is simple, quality stability good, and is easy to use, and quantitatively accurately, onset is rapid.
Su Bing (fast-acting heart disease curing) spray is by Styrax, Borneolum Syntheticum, solubilizing agent, absorption enhancer, solvent composition.It by weight
Percent by volume (w/v%) proportioning is following:
Styrax 0.1～25%
Borneolum Syntheticum 0.1～50%
Solubilizing agent 0.1%～99%
Absorption enhancer 0～5%
Solvent to 100%
Above-mentioned solvent is ethanol, glycerol, water, propylene glycol or its mixture, and solubilizing agent can be selected one or more in the following material for use:
(1) fatty acid Pyrusussuriensis smooth (Span) type material comprises sorbitan laurate (Span 20), Sorbitan Palmitate (Span 40), sorbitan stearate (Span 60), Sorbitan Tristearate (Span 65), Sorbitan Oleate (Span 80), Sorbitan Trioleate (Span 85) or its mixture;
(2) Polysorbate (Tween) type material comprises polysorbate 20 (Tween 20), polysorbate 40 (Tween 40), polysorbate 60 (Tween 60), polysorbate 65 (Tween 65), polyoxyethylene sorbitan monoleate (Tween 80), polysorbate 85 (Tween 85) or its mixture;
(3) polyoxyethylene fatty acid ester (Myrij) type material comprises Myrj 52;
(4) polyoxyethylene aliphatic alcohol ether class (Brij) material comprises Brij30, Brij35, paregal O or its mixture;
(5) polyoxyethylene-polyoxypropylene copolymer comprises poloxamer (poloxamer) new model or its mixture of poloxamer 188 (poloxamer 188), poloxamer 237 (poloxamer 237), poloxamer 338 (poloxamer338), poloxamer 407 (poloxamer407) and new listing;
(6) Polyethylene Glycol (PEG) type material comprises Macrogol 200 (PEG200), Liquid Macrogol (PEG300), PEG400 (PEG400), Macrogol 600 (PEG600), cetomacrogol 1000 (PEG1000), Macrogol 4000 (PEG4000) or its mixture.
(7) cyclodextrin (CD) type material; Comprise beta-schardinger dextrin-, alpha-cyclodextrin, gamma-cyclodextrin, hydroxypropyl beta cyclodextrin, malt-base cyclodextrin, galactosyl cyclodextrin, hydroxypropyl cyclodextrin, hydroxyethyl-, Methyl flamprop, branched cyclodextrin etc., single with or select its mixture for use
(8) sodium lauryl sulphate, cetyltrimethylammonium base ammonium bromide or its mixture.
Absorption enhancer can be selected one or more of following material for use, also can not add:
Sodium lauryl sulphate, laurocapram, lauric acid, sodium laurate, lecithin, oleic acid, poloxamer, phosphocholine etc., or its mixture.
Su Bing (fast-acting heart disease curing) spray method for preparing adds Styrax, Borneolum Syntheticum in above-mentioned solvent, the blended solution of solubilizing agent and to dissolve, and uses dispersing emulsification machine constant speed mixing, in spray (or aerosol) container of quantitatively packing into, finished product.
Method for using: directly spray into the oral cavity or nasal cavity gets final product, each 1-5 spray.
The invention solves the problems of dissolution of Borneolum Syntheticum and Storax oil.With almost completely water-fast Borneolum Syntheticum be not dissolved in jointly in the water-soluble base of orally-ingestible with the Storax oil of water immiscible phase, the oral administration solution that makes is transparent and homogeneous solution, the not stratified suspension that also do not appear.The spray of the present invention preparation can be quantitatively directly swallowed in the entrance or is sprayed on sublingual administration.Styrax and Borneolum Syntheticum are processed the spray oral administration, not only carry with easy to use, and than solid preparation absorb fast, rapid-action, help bringing into play better curative effect, be more suitable for angina pectoris patient medication.And this product is compared with solid preparation, has avoided a large amount of evaporable defectives of Borneolum Syntheticum in preparation process and the storage process, has guaranteed the stability of product quality.This product preparation method is simple, and used supplementary material is easy to get, and is suitable for the big production of industry, has good application prospects.
The specific embodiment
Embodiment 1
Storax oil 5 grams, Borneolum Syntheticum 10 grams, 15 milliliters of dehydrated alcohol, 65 milliliters of PEG400s, water add to 100 milliliters.Take by weighing Borneolum Syntheticum and Storax oil according to the above ratio and be dissolved in dehydrated alcohol and the PEG400, stir, add water to capacity, use dispersing emulsification machine to stir, in the spray container of quantitatively packing into, get finished product.
Directly spray into the oral cavity during use and get final product, a 1-3 spray.
Embodiment 2
Storax oil 5 grams, Borneolum Syntheticum 10 grams, 10 milliliters of propylene glycol, 28 milliliters of polyoxyethylene sorbitan monoleates (Tween 80), 20% ethanol adds to 100 milliliters.Take by weighing Borneolum Syntheticum and Storax oil according to the above ratio and join in the polyoxyethylene sorbitan monoleate (Tween 80), stir, add 20% ethanol to capacity, dispersing emulsification machine stirs, and in the aerosol container of quantitatively packing into, gets finished product.
Directly spray into the oral cavity during use and get final product, a 1-3 spray.
Embodiment 3
Storax oil 1 gram, Borneolum Syntheticum 2 grams, poloxamer 188 (poloxamer 188) 5 grams, 35% ethanol adds to 100 milliliters.Take by weighing Borneolum Syntheticum, Storax oil and poloxamer according to the above ratio and be dissolved in 35% ethanol, dispersing emulsification machine stirs, and in the spray container of quantitatively packing into, gets finished product.
Directly spray into the oral cavity during use and get final product, a 1-5 spray.
Embodiment 4
Storax oil 1 gram, Borneolum Syntheticum 2 grams, sodium lauryl sulphate 2 grams, 50% ethanol water adds to 100 milliliters.Take by weighing Borneolum Syntheticum, Storax oil and sodium lauryl sulphate according to the above ratio and be dissolved in 50% ethanol, dispersing emulsification machine stirs, and in the spray container of quantitatively packing into, gets finished product.
Directly spray into nasal cavity during use and get final product, a 1-3 spray.
Embodiment 5
Storax oil 1 gram, Borneolum Syntheticum 2 grams, HP-1 gram, sorbitan stearate (Span 60) 1 gram, 60% ethanol adds to 100 milliliters.Take by weighing Borneolum Syntheticum, Storax oil and sorbitan stearate according to the above ratio and be dissolved in 60% ethanol, the high speed dispersing emulsification machine stirs, and in the aerosol container of quantitatively packing into, gets finished product.
Directly spray into nasal cavity during use and get final product, a 1-5 spray.
Claims (8)
1. Su Bing (fast-acting heart disease curing) spray is by Styrax, Borneolum Syntheticum, solubilizing agent, absorption enhancer, solvent composition.Its spy
Levy and be: percent by volume (w/v%) proportioning is following by weight for it:
Styrax 0.1～25%
Borneolum Syntheticum 0.1～50%
Solubilizing agent 0.1%～99%
Absorption enhancer 0～5%
Solvent to 100%
2. the described spray of claim 1 promptly comprises the spray of liquid state, also comprises the spray of aerial fog type.
3. the described spray of claim 1, wherein said solvent is selected from ethanol, glycerol, water, propanol or its mixture.
4. according to claim 1 or claim 2 spray, wherein said solubilizing agent is selected from: fatty acid Pyrusussuriensis smooth (Span) type material, Polysorbate (Tween) type material, polyoxyethylene fatty acid ester (Myrij) type material, polyoxyethylene aliphatic alcohol ether class (Brij) material, polyoxyethylene-polyoxypropylene copolymer, Polyethylene Glycol (PEG) type material, cyclodextrin, sodium lauryl sulphate, cetyltrimethylammonium base ammonium bromide or its mixture.
5. spray as claimed in claim 3, wherein said fatty acid Pyrusussuriensis smooth (Span) type material can be selected from sorbitan laurate (Span 20), Sorbitan Palmitate (Span 40), sorbitan stearate (Span 60), Sorbitan Tristearate (Span65), Sorbitan Oleate (Span 80), Sorbitan Trioleate (Span 85) or its mixture; Said Polysorbate (Tween) type material is optional from polysorbate 20 (Tween 20), polysorbate 40 (Tween 40), polysorbate 60 (Tween 60), polysorbate 65 (Tween 65), polyoxyethylene sorbitan monoleate (Tween 80), polysorbate 85 (Tween 85) or its mixture; Said polyoxyethylene fatty acid ester (Myrij) type optional selfpolyoxyethylene 40 stearates of material; Said polyoxyethylene aliphatic alcohol ether class (Brij) material can be selected from Brij30, Brij35, paregal O or its mixture; Said polyoxyethylene-polyoxypropylene copolymer can be selected from poloxamer (poloxamer) new model or its mixture of poloxamer 188 (poloxamer 188), poloxamer 237 (poloxamer 237), poloxamer 338 (poloxamer338), poloxamer 407 (poloxamer407) and new listing; Said Polyethylene Glycol (PEG) type material is optional from Polyethylene Glycol 200 (PEG200), Liquid Macrogol (PEG300), PEG400 (PEG400), Macrogol 600 (PEG600), cetomacrogol 1000 (PEG1000), Macrogol 4000 (PEG4000) or its mixture; Said cyclodextrin material can be selected from beta-schardinger dextrin-, alpha-cyclodextrin, gamma-cyclodextrin, hydroxypropyl beta cyclodextrin, malt-base cyclodextrin, galactosyl cyclodextrin, hydroxypropyl cyclodextrin, hydroxyethyl-, Methyl flamprop, branched cyclodextrin etc., single with or select its mixture for use.
6. the described spray of claim 1, wherein said absorption enhancer is selected from sodium lauryl sulphate, laurocapram, lauric acid, sodium laurate, lecithin, oleic acid, poloxamer, phosphocholine etc., or its mixture, also can not add.
7. one kind prepares the described Su Bing of claim 1 (fast-acting heart disease curing) spray preparing process; It is characterized in that: Styrax, Borneolum Syntheticum are added in above-mentioned solvent, the blended solution of solubilizing agent dissolve; The use dispersing emulsification machine stirs, and in spray (or aerosol) container of quantitatively packing into then, gets finished product.
8. its use field of the described Su Bing of claim 1 (fast-acting heart disease curing) spray is uncomfortable in chest, the angina pectoris of treatment coronary heart disease, myocardial infarction, hepatic coma or the like acute cardiac disease; And be people's oral cavity or nasal cavity applied medicine, each 1-5 spray.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102597358A CN102370673A (en) | 2010-08-23 | 2010-08-23 | Subing (quick effect heart rescue) spraying agent and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102597358A CN102370673A (en) | 2010-08-23 | 2010-08-23 | Subing (quick effect heart rescue) spraying agent and its preparation method |
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| CN102370673A true CN102370673A (en) | 2012-03-14 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2010102597358A Pending CN102370673A (en) | 2010-08-23 | 2010-08-23 | Subing (quick effect heart rescue) spraying agent and its preparation method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103623365A (en) * | 2013-08-08 | 2014-03-12 | 马建 | Externally-applied medicine for rapid cardiac first aid and preparation method thereof |
| CN107582414A (en) * | 2017-09-22 | 2018-01-16 | 广东柏文生物科技股份有限公司 | The two-in-one spray of dynamic water and milk |
| WO2021224664A1 (en) * | 2020-05-06 | 2021-11-11 | Pvp Labs Pte. Ltd. | Application of dalargin for the prevention of vris and prevention of the development of complications during vris |
Citations (7)
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| CN1096672A (en) * | 1993-06-22 | 1994-12-28 | 丛繁滋 | Warming and resuscitation inducing aerosol and preparation method thereof |
| WO2004043436A1 (en) * | 2002-11-13 | 2004-05-27 | Fanzi Cong | Medicinal aerosol comprising plant essential oil and its preparation |
| EP1424077A1 (en) * | 2001-08-08 | 2004-06-02 | Huazhong University of Science and Technology | Isulin-containing oral spray and the preparation method thereof |
| JP2006069946A (en) * | 2004-09-01 | 2006-03-16 | Aska Pharmaceutical Co Ltd | Aqueous suspension for microdetermination spraying |
| CN1931201A (en) * | 2005-09-12 | 2007-03-21 | 王登之 | Subing spray and its prepn process |
| CN101442987A (en) * | 2005-12-14 | 2009-05-27 | 扎尔斯制药公司 | Compositions and methods for treating dermatological conditions |
| CN101780038A (en) * | 2010-03-30 | 2010-07-21 | 上海现代药物制剂工程研究中心有限公司 | Zolpidem tartrate oral spraying agent and preparation method thereof |
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2010
- 2010-08-23 CN CN2010102597358A patent/CN102370673A/en active Pending
Patent Citations (7)
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|---|---|---|---|---|
| CN1096672A (en) * | 1993-06-22 | 1994-12-28 | 丛繁滋 | Warming and resuscitation inducing aerosol and preparation method thereof |
| EP1424077A1 (en) * | 2001-08-08 | 2004-06-02 | Huazhong University of Science and Technology | Isulin-containing oral spray and the preparation method thereof |
| WO2004043436A1 (en) * | 2002-11-13 | 2004-05-27 | Fanzi Cong | Medicinal aerosol comprising plant essential oil and its preparation |
| JP2006069946A (en) * | 2004-09-01 | 2006-03-16 | Aska Pharmaceutical Co Ltd | Aqueous suspension for microdetermination spraying |
| CN1931201A (en) * | 2005-09-12 | 2007-03-21 | 王登之 | Subing spray and its prepn process |
| CN101442987A (en) * | 2005-12-14 | 2009-05-27 | 扎尔斯制药公司 | Compositions and methods for treating dermatological conditions |
| CN101780038A (en) * | 2010-03-30 | 2010-07-21 | 上海现代药物制剂工程研究中心有限公司 | Zolpidem tartrate oral spraying agent and preparation method thereof |
Non-Patent Citations (1)
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| 季宏伟: "川苏喷雾剂对心绞痛的疗效观察", 《河南中医》, vol. 27, no. 6, 30 June 2007 (2007-06-30), pages 73 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103623365A (en) * | 2013-08-08 | 2014-03-12 | 马建 | Externally-applied medicine for rapid cardiac first aid and preparation method thereof |
| CN107582414A (en) * | 2017-09-22 | 2018-01-16 | 广东柏文生物科技股份有限公司 | The two-in-one spray of dynamic water and milk |
| CN107582414B (en) * | 2017-09-22 | 2020-09-11 | 广东柏文生物科技股份有限公司 | Dynamic water-emulsion two-in-one spray |
| WO2021224664A1 (en) * | 2020-05-06 | 2021-11-11 | Pvp Labs Pte. Ltd. | Application of dalargin for the prevention of vris and prevention of the development of complications during vris |
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Application publication date: 20120314 |