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Publication numberCN102076372 A
Publication typeApplication
Application numberCN 200980125520
PCT numberPCT/EP2009/002806
Publication date25 May 2011
Filing date17 Apr 2009
Priority date2 May 2008
Also published asCA2723260A1, CN102076372B, EP2274029A1, EP2274029B1, US9717859, US9802003, US20140039410, US20160310669, US20160331906, WO2009132777A1
Publication number200980125520.2, CN 102076372 A, CN 102076372A, CN 200980125520, CN-A-102076372, CN102076372 A, CN102076372A, CN200980125520, CN200980125520.2, PCT/2009/2806, PCT/EP/2009/002806, PCT/EP/2009/02806, PCT/EP/9/002806, PCT/EP/9/02806, PCT/EP2009/002806, PCT/EP2009/02806, PCT/EP2009002806, PCT/EP200902806, PCT/EP9/002806, PCT/EP9/02806, PCT/EP9002806, PCT/EP902806
Inventors多米尼克G韦伯, 斯蒂芬拉布, 杰弗里P格雷, 特雷弗J贝克特, 约翰D克罗斯, 詹姆斯R豪沃思, 迈克尔哈姆斯
Applicant赛诺菲-安万特德国有限公司
Export CitationBiBTeX, EndNote, RefMan
External Links: SIPO, Espacenet
Medication delivery device
CN 102076372 A
Abstract
The invention refers to a medication delivery device (1) comprising: a housing (3) having a proximal and a distal end, a medication receptacle (2) designed to be engaged with the housing (3), a piston rod (17) which is moveable in a distal direction for medication delivery and a drive device for rotating the piston rod in a first rotational direction and thereby moving the piston rod (17) in the distal direction for medication delivery; The piston rod comprises two threaded sections (15, 16), wherein a first threaded section (15) is provided for threaded engagement with a reset element (11) and a second threaded section (16) is provided for threaded engagement with the drive device and wherein the threads in the first and second threaded sections (15, 16) are oppositely disposed, wherein in an operational state the reset element (11) is prevented from rotation with respect to the housing (3), the piston rod (17) being prevented from moving in a proximal direction, and in a resetting state the reset element (11) is allowed to rotate with respect to the housing (3), the medication delivery device being resettable by rotating the piston rod (17) and the reset element (11) in a secondrotational direction and thereby moving the piston rod (17) in the proximal direction.
Claims(29)  translated from Chinese
1. 一种药物输送设备(1),包括:具有近端和远端的壳体(3);设计成与所述壳体(接合的药物容器O);能向远端方向移动以输送药物的活塞杆(17);和驱动设备,所述驱动设备用于向第一旋转方向旋转所述活塞杆并因此向远端方向移动所述活塞杆(17),以输送药物;其特征在于,所述活塞杆包括两个螺纹区段(15、16),其中第一螺纹区段(1用于螺纹接合复位元件(11),而第二螺纹区段(16)用于螺纹接合所述驱动设备,并且所述第一和第二螺纹区段内的螺纹相对设置,其中在操作状态下,所述复位元件(11)被阻止相对于所述壳体C3)旋转,因此所述活塞杆(17)被阻止向近端方向移动;和在复位状态下,所述复位元件(11)被允许相对于所述壳体C3)旋转,通过向着第二旋转方向旋转所述活塞杆(17)和所述复位元件(11)并向近端方向移动所述活塞杆(17),从而将所述药物输送设备复位。 A drug delivery device (1), comprising: a housing having a proximal end and a distal end (3); and the housing is designed to ( engaging medicament container O); can be moved in the distal direction to deliver Drug piston rod (17); and a drive device, the drive device for rotating the first rotational direction and thereby moving the piston rod in the distal direction of the piston rod (17), to deliver the drug; wherein , the piston rod comprises two threaded sections (15, 16), wherein a first threaded section (1 for threaded engagement reset element (11), while the second threaded section (16) for engaging said threaded drive device, and the first and second screw threaded section disposed within opposite, which in the operating state, the reset element (11) with respect to the housing is prevented C3) rotation, and therefore the piston rod (17) is prevented from moving in the proximal direction; and in the reset state, the reset element (11) with respect to the housing is allowed to C3) is rotated by rotating a second rotational direction toward the piston rod (17) and the reset element (11) to the proximal direction of the piston rod (17), whereby the drug delivery device is reset.
2.如权利要求1所述的药物输送设备(1),其特征在于,在所述药物容器(接合所述壳体(3)的远端时,所述复位元件(11)处于所述操作状态;和当所述药物容器(从所述壳体(3)的远端脱开时,所述复位元件处于所述复位状态。 2. As 1, wherein the drug delivery device (1) according to claim, wherein, in said medication container ( engages the distal end of the housing (3), said resetting element (11) is in the operating state; and when the medication container ( disengaged from the distal end of the housing (3) when the reset element is in the reset state.
3.如权利要求1或2所述的药物输送设备(1),其特征在于,所述药物容器(设计成通过接合第一接合装置(5)和第二接合装置(4)而与所述壳体(3)的远端接合,利用所述药物容器(的运动,所述第一接合装置(和所述第二接合装置(4)形成接合,所述药物容器的运动包括所述药物容器(相对于所述壳体(3)的旋转运动而不存在轴向移动。 3. The 1 or 2, wherein the drug delivery device (1) according to claim, characterized in that said medicament container ( designed by engaging a first engagement means (5) and second engagement means (4) and the the distal end of said housing (3) engages with said medication container ( of movement, the first engagement means ( and said second engagement means (4) into engagement, the movement of the medicament container comprises rotational movement of said medication container ( relative to the housing (3) without the presence of axial movement.
4.如权利要求1至3任一项所述的药物输送设备(1),其特征在于,所述药物容器(2) 包括用于将所述复位元件(11)带入所述操作状态的促动装置(70)。 4. 1-3 according to any one of medicament delivery device (1) according to claim, characterized in that said medicament container (2) comprises means for the resetting element (11) into the operational state actuating means (70).
5.如权利要求4所述的药物输送设备(1),其特征在于,所述第一和第二接合装置(5、 4)设计成,在所述药物容器(和所述壳体移动而形成接合时,所述促动装置首先旋转并相对于所述壳体轴向移动,然后旋转而不发生轴向移动,由此所述促动装置(70)将所述复位元件(11)带入所述操作状态。 5. 4 wherein the drug delivery device (1) as claimed in claim wherein said first and second engagement means (5, 4) is designed, the medicament container ( and moving in the housing while forming the engaging said first actuating means to rotate and move axially relative to the housing, without the risk of axial movement and rotation, whereby said actuator means (70) to said reset member (11) brought into the operating state.
6.如权利要求3至5任一项所述的药物输送设备(1),其特征在于,所述药物容器(2) 或所述药物容器(的插件包括所述第一接合装置(5),而所述壳体C3)或所述壳体(3)的插件(3A)包括所述第二接合装置(4)。 6. A drug delivery device according to any one of 3-5 (1) according to claim, characterized in that said medicament container (2) or said medicament container ( plug comprises the first engagement means (5 ), and said housing C3) or the housing (3) of the plug (3A) comprises the second engagement means (4).
7.如权利要求3至6任一项所述的药物输送设备(1),其特征在于,所述第一接合装置(5)是所述药物容器(的螺纹,而所述第二接合装置(4)是所述壳体(或所述壳体(3) 的插件(3A)上用于接合所述药物容器的所述螺纹的接合元件,其中所述药物容器(的螺纹的远端合并入环形凹槽,以使所述药物容器(2)利用首先相对于所述壳体(3)旋转并向近端移动然后仅相对于所述壳体(旋转而与所述壳体(接合。 Drug delivery device according to any one of claims 3 to 6, (1) as claimed in claim 7. The second engagement, characterized in that said first engagement means (5) said medication container ( threads, while the means (4) is the housing ( or the housing (3) of the plug (3A) engaging said threaded member engaging the container for the medicament, wherein the medicament container ( of the thread incorporated into the distal end of the annular groove, so that the medicament container (2) with respect to the use of the first housing (3) rotates and moves proximally with respect to the housing and then only ( rotation with the shell body ( engagement.
8.如权利要求3至7任一项所述的药物输送设备(1),其特征在于,所述壳体(3)的远端设置有包括设计成与所述药物容器(的近端的所述第一接合装置(接合的所述第二接合装置的插件(3B),所述插件(3B)固紧而不能旋转,但是能相对于所述壳体(3)自由地轴向移动,其中所述插件(3B)向远端的轴向移动受到保持装置(6的限制。 8. The drug delivery device according to any one of claims 3 to 7 (1) as claimed in claim wherein said housing (3) comprises a distal end provided with said medication container designed ( proximal end said first engagement means ( plug engaging said second engagement means (3B), the insert (3B) secured against rotation, but freely axially relative to the housing (3) mobile, wherein the insert (3B) subjected to axial movement of the distal end of the holding device (restrictions 6 in.
9.如权利要求8所述的药物输送设备(1),其特征在于,所述壳体的所述插件(3B)包括内螺纹作为用于接合第一接合装置(5)的第二接合装置G),所述第一接合装置是位于所述药物容器(近端的外螺纹,在用于接合所述药物容器(与所述壳体(3)的第一步骤中,所述药物容器(相对于所述插件和所述壳体C3)旋转并轴向移动,在用于接合所述药物容器(与所述壳体(3)的第二步骤中,所述药物容器(旋转,但是所述药物容器(2)相对于所述壳体C3)的轴向移动被阻止,在所述第二步骤中,所述插件(3B)利用所述药物容器O)的旋转来向远端方向移动。 9. The drug delivery device according to 8 (1) as claimed in claim wherein said plug (3B) of the housing comprises an inner thread as a second engagement means for engaging a first engagement means (5) G), said first engagement means is located outside said medication container thread ( proximal end, in a first step for engaging the medicament container ( of the housing (3), said medicament Container ( with respect to the plug housing and the C3) rotate and move axially, in a second step for engaging the medicament container ( of the housing (3), said medication container ( rotation, but said medication container (2) with respect to the housing C3) axial movement is prevented, in the second step, the insert (3B) with said medication container O) of rotation moved in the distal direction.
10.如权利要求1至9任一项所述的药物输送设备(1),其特征在于,所述复位元件(11)是螺纹接合所述活塞杆(17)的外螺纹的螺母装置。 1 to 10. The drug delivery device according to any one of claims 9 (1) according to claim, characterized in that the reset element (11) is a nut means threadedly engaged with the external threads of the piston rod (17).
11.如权利要求1至10任一项所述的药物输送设备(1),其特征在于,所述驱动设备包括驱动套筒(19),所述活塞杆(17)的所述第二螺纹区段(16)用于螺纹接合所述驱动套筒(19)。 1 to 11. A drug delivery device 10 according to any one of (1) as claimed in claim wherein said drive device comprises a drive sleeve (19), said piston rod (17) of the second thread section (16) for threaded engagement with the drive sleeve (19).
12.如权利要求11所述的药物输送设备(1),其特征在于,所述驱动套筒(19)与所述活塞杆(17)接合,用于在输送药物的过程中向远端方向驱动所述活塞杆(17),在输送药物过程中,所述驱动套筒(19)轴向移动并被阻止相对于所述壳体(3)旋转,由此导致所述活塞杆(17)发生轴向移动和旋转。 11 12. The medication delivery device (1) as claimed in claim wherein said drive sleeve (19) with said piston rod (17) engaged in the distal direction for medication delivery process in driving said piston rod (17), in the process of drug delivery, the drive sleeve (19) and prevented from axial movement relative to the housing (3) is rotated, thereby causing the piston rod (17) occurrence axial movement and rotation.
13.如权利要求11或12任一项所述的药物输送设备(1),其特征在于,止挡装置,所述止挡装置设计成,在剂量设定过程中,允许所述驱动套筒(19)相对于所述壳体C3)轴向移动且旋转,同时不允许所述驱动套筒(19)相对于所述壳体C3)轴向移动而不发生旋转;和在剂量输送过程中,不允许所述驱动套筒(19)相对于所述壳体C3)旋转,同时允许所述驱动套筒(19)相对于所述壳体(3)向远端方向轴向移动而不发生旋转。 11 or 13. A drug delivery device 12 according to any one of (1) claim, characterized in that the stop means, the stop means are designed to, during dose setting, allowing the drive sleeve (19) with respect to the housing C3) and axial movement of rotation, while not allowing the drive sleeve (19) relative to said housing C3) rotate without axial movement; and in the dose delivery process , does not allow the drive sleeve (19) relative to said housing C3) rotation, while allowing the drive sleeve (19) relative to the housing (3) to move axially in the distal direction without the risk of rotation.
14.如权利要求13所述的药物输送设备(1),其特征在于,所述止挡装置包括与所述驱动套筒(19)不可转动地接合的离合器装置04)。 14. The medicament of claim 13, wherein the delivery device (1), characterized in that said stop means comprises a drive sleeve (19) nonrotatably engaging the clutch device 04).
15.如权利要求11至14任一项所述的药物输送设备(1),其特征在于,包括配量机构, 所述配量机构包括所述活塞杆(17)和所述驱动设备,所述配量机构进一步包括:剂量拨转套筒(27),所述剂量拨转套筒具有与所述壳体(3)的螺旋螺纹接合的螺旋螺纹,所述驱动套筒(19)可释放地耦接到所述剂量拨转套筒07);和离合器装置(M),所述离合器装置位于所述剂量拨转套筒、2Τ)和所述驱动套筒(19) 之间,其中a)当所述剂量拨转套筒(XT)和所述驱动套筒(19)耦接时,两者都被允许相对于所述壳体(3)旋转;和b)当所述剂量拨转套筒(XT)和所述驱动套筒(19)脱开时,所述剂量拨转套筒(XT)相对于所述壳体(的旋转被允许,而所述驱动套筒(19)相对于所述壳体(的旋转不被允许,并且所述驱动套筒(19)向着远端方向的轴向移动被允许,由此将作用力向着远端方向传递到所述活塞杆(17)。 11 to 15. A drug delivery device 14 according to any one of (1) claim, characterized in that the dosing mechanism comprising a dosing mechanism comprising a piston rod (17) and said drive device, the said metering means further comprising: a dose dial sleeve (27), said dose dial sleeve having a helical thread of the housing (3) engages the helical thread of the drive sleeve (19) is releasably coupled to the dose dial sleeve 07); and a clutch means (M), said clutch means in said dose dial sleeve, 2Τ) and between said drive sleeve (19), wherein a ) when the dose dial sleeve (XT) and the drive sleeve (19) is coupled, both are allowed with respect to the housing (3) rotation; and b) when the dose dial sleeve (XT) and the drive sleeve (19) is disengaged when said dose dial sleeve (XT) with respect to the housing ( rotation is allowed, while the drive sleeve (19) relative to the housing ( rotation is not allowed, and the drive sleeve (19) towards the distal direction of axial movement is allowed, whereby the distal direction toward the force transmitted to the piston rod ( 17).
16.如权利要求1至15任一项所述的药物输送设备(1),其特征在于,所述药物输送设备(1)包括锁止装置(9),所述锁止装置不能相对于壳体(3)旋转,并且与处于所述操作状态下的所述复位元件(11)接合,由此锁止所述复位元件(11),阻止所述复位元件(11)相对于所述壳体C3)旋转。 1 to 16. The drug delivery device 15 according to any one of (1) claim, wherein the drug delivery device (1) comprises a locking means (9), said locking means relative to the housing is not body (3) is rotated, and the reset element in the operational state (11) engages, thereby locking the reset element (11), to prevent the reset element (11) with respect to the housing C3) rotation.
17.如权利要求16所述的药物输送设备(1),其特征在于,所述复位元件(11)是螺母装置,所述螺母装置螺纹接合所述活塞杆(17)并且在操作状态下与所述锁止装置接合。 16 17. The medication delivery device (1) as claimed in claim wherein said reset member (11) is a nut means, said nut means engaging said threaded rod (17) and in the operating state and engaging the locking device.
18.如权利要求16或17任一项所述的药物输送设备(1),其特征在于,所述锁止装置(9)和所述复位元件(11)包括端面齿(10、12),当所述锁止装置(9)和所述复位元件(11) 在操作状态下接合时,所述端面齿互锁。 18. A medicament according to any one of claims 16 or 17, delivery device (1), characterized in that said locking means (9) and the reset element (11) comprises a toothed end face (10, 12), When the locking device (9) and the reset element (11) engages in the operating state, the end tooth interlock.
19.如权利要求16至18任一项所述的药物输送设备(1),其特征在于,在所述药物容器(2)从所述壳体(3)脱开时,在偏压装置(14)的作用力作用下,所述锁定装置(9)和所述复位元件(11)脱开。 19. A drug delivery device as claimed in any one of 16 to 18 (1) as claimed in claim wherein, in said medication container (2) from the housing (3) is disengaged, the biasing means ( Under 14) force effect, said means (9) and the lock reset member (11) is disengaged.
20.如权利要求16至19任一项所述的药物输送设备(1),其特征在于,在所述药物容器(从所述壳体C3)脱开时,所述锁止装置(9)和所述复位元件(11)脱开,由此所述复位元件(11)在复位状态下相对于所述壳体(3)自由旋转。 20. A drug delivery device according to any one of claims 16 to 19, (1) as claimed in claim wherein, when the medicament container ( from the casing C3) disengages said locking means (9 ) and the reset element (11) is disengaged, and (3) is free to rotate relative to the housing whereby the reset element (11) in the reset state phasor.
21.如权利要求1至20任一项所述的药物输送设备(1),其特征在于,所述药物容器(2)是管筒保持件,所述管筒保持件设计成接收填充有药物的管筒(6)。 1 to 21. The drug delivery device 20 according to any one of (1) as claimed in claim wherein said medicament container (2) is a cartridge holder, the cartridge holder is filled with a drug designed to receive The tube (6).
22.如权利要求1至21任一项所述的药物输送设备(1),其特征在于,所述药物容器(2)以及所述壳体C3)设置有搭扣特征件,借助所述搭扣特征件,所述药物容器(和所述壳体C3)保持可释放的接合。 1 to 22. A drug delivery device 21 according to any one of (1) as claimed in claim wherein said medicament container (2) and the casing C3) is provided with a fastener member wherein, by means of the ride buckle feature piece, said medication container ( and said housing C3) remains engaged releasable.
23.如权利要求1至22任一项所述的药物输送设备(1),其特征在于,在所述第一螺纹区段中,所述活塞杆具有节距为第一节距的螺纹,而在所述第二螺纹区段中,所述活塞杆具有节距为第二节距的螺纹,其中所述第一节距小于所述第二节距。 23. 1 to 22. A medicament according to any delivery device (1) according to claim, characterized in that said first threaded section, said piston rod having a screw thread pitch of the first pitch, In the second threaded section, said piston rod having a screw thread pitch of the second pitch, wherein the first pitch is smaller than the second pitch.
24.如权利要求1至23任一项所述的药物输送设备(1),其特征在于,所述药物输送设备是笔型设备。 1 to 24. A drug delivery device according to any one of 23 (1) as claimed in claim wherein said drug delivery device is a pen-type device.
25.如权利要求1至M任一项所述的药物输送设备(1),其特征在于,所述药物输送设备是注射器型设备。 25. any one of claims 1 to M medicament delivery device according to claim (1), characterized in that said drug delivery device is a syringe-type device.
26.如权利要求1至25任一项所述的药物输送设备(1),其特征在于,所述药物输送设备⑴包括针管。 1 to 26. The drug delivery device 25 according to any one of (1) claim, wherein the drug delivery device comprises a needle cannula ⑴.
27.利用权利要求1至沈任一项所述的药物输送设备(1)配送药物产品的用途。 27. The use as claimed in any one of claims 1 to sink the drug delivery device (1) distribution of a pharmaceutical product.
28.如权利要求27所述的药物输送设备(1)的用途,用于配送制剂配方,所述制剂配方包括从以下选择的活性化合物:胰岛素、生长激素、小分子量肝素、它们的类似物以及它们的衍生物。 28. The drug delivery device 27 according to (1) claim the use of, for dispensing Formulation, the formulation of the active compound from the formulation comprises the following selection: insulin, growth hormone, low molecular weight heparin, their analogues and derivatives thereof.
29. 一种制造或组装如权利要求1至沈所述药物输送设备(1)的方法。 29. A method of manufacturing or assembling such a drug delivery device to the sink (1) The method of claim.
Description  translated from Chinese

药物输送设备 Drug delivery device

技术领域 Technical Field

[0001] 本发明涉及药物输送设备,该设备的用途以及制造或组装该设备的方法。 [0001] The present invention relates to a drug delivery device, use of the device and method of manufacturing or assembling the device. 本发明特别涉及适合用在药物输送设备特别是笔型注射器中的配量机构,所述笔形注射器优选具有剂量设定装置和驱动设备,允许从单剂量或多剂量药物管筒进行药物产品的给药。 The present invention particularly relates to a drug delivery device suitable for use in particular pen-type syringe dosing mechanism, the pen-shaped syringe preferably having dose setting means and the drive device, allowing for pharmaceutical products from single or multiple doses of the drug to the tube drugs. 具体来说,本发明涉及这样一种药物输送设备,其中使用者可以设定从多剂量管筒输送的药物剂量。 Specifically, the present invention relates to pharmaceutical dosage in such a drug delivery device, where the user can set the tube from a multi-dose delivery. 最优选,所述药物输送设备包括单剂量或多剂量药物管筒,该药物管筒可以在药物完全配送之后进行更换。 Most preferably, the drug delivery device comprises a single dose or multiple dose barrel, the drug property management cylinder can be replaced after the distribution of the drug entirely.

[0002] 本发明进一步涉及用于药物输送设备的复位机构,并特别涉及包括复位元件的复位机构,该复位元件与药物输送设备的活塞杆接合。 [0002] The present invention further relates to a reset mechanism for a drug delivery device, and more particularly to a reset mechanism includes a reset element, the piston rod of the return element engages with the drug delivery device. 最优选,根据本发明的复位机构通过药物容器与药物输送设备的壳体接合和脱开而分别被激活或去活。 Most preferably, the reset mechanism of the present invention, the drug delivery device in the container with the drug case by engagement and disengagement were activated or deactivated.

背景技术 Background

[0003] 所述药物输送设备在未接受正规医疗培训的人,即病人进行常规注射的情况下, 具有用武之地。 [0003] The person of the drug delivery device without formal medical training, that is the case for regular injections of the patient, has its uses. 这在患有糖尿病的病人当中逐渐变得普遍,其中自我治疗使得这些人可以有效地管理他们的糖尿病。 It gradually became popular among patients with diabetes, in which the self-healing so that these people can effectively manage their diabetes.

[0004] 这种场合为这类药物输送设备设定了许多要求。 [0004] In this case for such a drug delivery device is set up many of the requirements. 所述设备必须结构牢固,但在部件操控、使用者理解其操作以及输送要求剂量的药物方面又便于使用。 The device must be a solid structure, but in parts handling, user understanding of its operation, and the desired dose of medicament delivery and easy to use. 剂量设定必须容易且清晰。 Dose setting must be easy and clear. 在患有糖尿病的病人的情况下,许多使用者身体虚弱并且还可能视力受损,要求配量机构所具有的驱动设备需要较小的配送力并且药物输送设备具有容易阅读的剂量设定显不器。 In the case of patients with diabetes, many users may also frail and visually impaired, the amount of required driving device is equipped with a mechanism that requires less force distribution and drug delivery devices with easy to read dose setting was not device.

[0005] 受到环境和经济因素的影响,这类药物输送设备已经设计成,仅允许该设备的一部分在全部药物输送完成之后被抛弃,通常仅为药物管筒。 [0005] influenced by environmental and economic factors, such drug delivery device has been designed so that only a portion of the device allow abandoned after the completion of all drug delivery, typically only drug cartridge. 这对所述药物输送设备提出了额外的要求,即在新管筒连接或插入到药物输送设备时,驱动机构的复位应该容易且清晰, 而不需要使用者直接接触驱动机构的任何部件,由此降低例如因污染造成驱动机构损坏的可能性。 The drug delivery device which imposes additional requirements, that is, when a new connection or tube inserted into a drug delivery device, reset the drive mechanism should be easy and clear, without requiring the user to direct contact with any part of the drive mechanism by This reduces the possibility of damage due to pollution caused by the drive mechanism, for example.

[0006] 对所述可重复使用的设备的另一项要求是,在连接新管筒时,管筒内的塞头应该不会移动,因此在剂量设定和剂量输送之前,管筒内容物不会被加压。 [0006] Another requirement for the reusable devices is that when you connect a new tube, a tube of the plug should not move, so before dose setting and dose delivery, tube contents It will not be pressurized. 如果发生了这种情况,则可能影响该设备的精度。 If this happens, it may affect the accuracy of the device.

[0007] 在医疗领域里,使用者操作的药物输送设备是熟知的。 [0007] In the medical field, the drug delivery device operated by a user are well known.

[0008] W02004/078239A1公开了一种用于药物输送设备的驱动机构,所述药物输送设备包括:具有螺旋螺纹的壳体;具有与壳体的螺旋螺纹接合的螺旋螺纹的剂量拨转套筒;可释放地连接到所述剂量拨转套筒的驱动套筒;和位于所述剂量拨转套筒和所述驱动套筒之间的离合器装置。 [0008] W02004 / 078239A1 discloses a drive mechanism for a drug delivery device, the drug delivery device comprising: a housing having a helical thread; having a helical thread engaged with the helical thread of the housing of the dose dial sleeve ; releasably connected to the dose dial sleeve of the drive sleeve; and in said dose dial sleeve and a clutch means between the drive sleeve. 当剂量拨转套筒和驱动套筒经由离合器装置耦接时,两者都被允许相对于壳体旋转。 When the dose dial sleeve and the drive sleeve when the device is coupled via a clutch, both are allowed to rotation relative to the housing. 当剂量拨转套筒和驱动套筒脱开时,允许剂量拨转套筒相对于壳体旋转,而不允许驱动套筒相对于壳体旋转,由此允许驱动套筒轴向移动,以便作用力沿着纵向传递到活塞杆,用于输送药物。 When the dose dial sleeve and the drive sleeve disengaged allowing the dose dial sleeve with respect to the housing rotation, but does not allow rotation of the drive sleeve relative to the housing, thereby allowing the drive sleeve to move axially to the role longitudinal force transmitted to the piston rod for medication delivery. 该文件没有描述更换管筒,也没有描述驱动机构复位。 The document does not describe the replacement tube, do not describe the drive mechanism of the reset. [0009] 下述现有技术文件利用可抛弃并可更换的药物管筒解决了这种设备的重复使用问题,所述药物管筒可以与可重复使用(可复位)的驱动机构连接/脱开。 [0009] The following prior art documents utilize disposable and replaceable medicament tube solves repeated use of such a device, said drug cartridge may be a reusable (resettable) drive mechanism connected / disconnected .

[0010] 在EP05M996B1中公开了一种注射设备,该设备包括壳体和将包含内部活塞的包含流体的管筒安装到所述壳体的装置。 [0010] discloses an injection device in EP05M996B1, the device comprising a housing and a piston comprising an internal tube containing fluid mounted to said housing means. 丝杆可移动地安装在所述壳体中,并且设置剂量设定装置用于选择利用该设备输送的流体量。 Screw movably mounted in the housing and the dose setting means to set the amount of fluid for selecting the device utilizing delivered. 所述设备为更换管筒并复位可重复使用的注射设备的配量机构提供了解决方案。 The device is a replacement tube and reset the dosing mechanism of the reusable injection device provides a solution. 新的管筒插入所述壳体中,然后该管筒被旋拧就位,同时管筒的活塞将丝杆推入所述设备中,这种设备的缺点在于在旋拧结束时向活塞施加了压力。 The new tube is inserted into the housing, then the tube is screwed into place, while the screw plunger tube is pushed into the apparatus, the disadvantage of this device is that is applied to the piston at the end of the screwing pressure.

[0011 ] US5, 827,232教导了一种药物输送笔,包括可抛弃的含药物管筒组件。 [0011] US5, 827,232 teaches a drug delivery pen, including drug-containing tube assembly abandoned. 所述管筒组件包括包括管筒,所述管筒具有可刺穿的密封远端和柱塞,所述柱塞在所述管筒中形成滑动流体密封接合,从而在柱塞向远端方向滑动时,从所述管筒配送药物。 The tube assembly includes a tube comprising a tube having a distal end and a pierceable seal a plunger in sliding fluid sealing engagement of the tube in order to slide the plunger in the distal direction When the distribution of the drug from the tube. 此外,所述药物输送笔包括可重复使用的笔身组件,该笔身组件具有壳体、设置在壳体内的丝杆和用于在笔身组件内将丝杆向远端移动选定的量的驱动装置。 Additionally, the drug delivery pen comprising a pen body assembly may be reusable pen body assembly having a housing, the screw within the housing and disposed within the pen body assembly to the distal end of the screw to move the selected amount driving means. 虽然该设备为药物输送笔驱动机构复位提供了解决方案,但是要求使用者将管筒保持件与活塞杆远端的狭槽对准,这可能对于视力受损和/或行动不便的使用者造成困难。 While this device is a drug delivery pen drive mechanism of the reset to provide a solution, but requires the user to the cartridge holder and a slot aligned with the distal end of the piston rod, which may be for the visually impaired and / or mobility of the user causes difficult.

[0012] W01997/010864A1描述了一种药物输送笔,该笔包括用于保持具有柱塞的管筒的管筒保持组件,所述管筒保持组件近端具有多条螺纹。 [0012] W01997 / 010864A1 describes a drug delivery pen, the pen includes a tube having a plunger for holding the tube holding assembly, a proximal end of the tube holder assembly having a plurality of threads. 笔身组件远端包括多条螺纹用来与管筒保持组件中的螺纹咬合。 The distal end of the pen body assembly includes a plurality of threads used to keep the assembly thread engagement with the tube. 丝杆从远端延伸,用于接合管筒内的柱塞。 Screw extending from the distal end for engaging a tube of a plunger. 设置用于将丝杆驱动到管筒内的装置,以便向远端方向移动柱塞。 Provided for the screw drive to a tube of the means to move the plunger in the distal direction. 此外,设置将驱动装置从丝杆脱开的装置, 以允许在笔身组件接近管筒保持组件并螺纹连接到管筒保持组件时,丝杆自动且方便地缩回到笔身内。 In addition, setting the drive means is disengaged from the screw means, to allow the pen body assembly and close tube holding assembly is connected to the threaded tube holding assembly screw to automatically and easily retract into the pen body. 但是,所公开的用于将新管筒保持件组件安装到可重复使用的笔身组件的方案存在组装结束时向柱塞施加压力的缺陷。 However, the disclosed for the new tube attached to the pen body assembly reusable solutions exist to keep the assembly defect column 塞施加 pressure at the end of the assembly.

发明内容 DISCLOSURE

[0013] 本发明的目标是避免已知药物输送设备的缺陷,特别是提供一种用于药物输送设备中的灵活的复位机构,借助该复位机构,药物输送设备可以在更换药物管筒时进行复位以便重复使用。 [0013] The object of the present invention is to avoid defects known drug delivery devices, in particular to provide a drug delivery device for a flexible reset mechanism by which reset mechanism, the drug delivery device can be when changing drug cartridge reset for repeated use.

[0014] 根据本发明的药物输送设备为现有药物输送设备提供了一种有价值的技术替代品。 [0014] The drug delivery device of the present invention provides a valuable technical alternative to existing drug delivery device. 根据本发明的药物输送设备优势在于,当连接新管筒时,将活塞杆推回设备主体中,而使用者不需要接触配量机构的任何部件并且管筒塞头不发生任何移动。 The drug delivery device advantage of the present invention is that, when connecting a new barrel, pushing the piston back into the device body, and the user does not contact with any part of the dosing mechanism and tube plugs do not have any movement. 根据本发明的药物输送设备的优势在于,容易更换药物管筒,而且在设备复位过程中几乎不会对管筒塞头施加压力,因此在第一次设定并配送剂量之前,不会对管筒内的药物加压。 According to the advantages of the drug delivery device of the present invention is easy to replace drug cartridge, and the device reset process is almost not exert pressure on the tube plugs, so before the first set and the dose distribution, not on the tube cylinder pressure medications.

[0015] 根据本发明,提供了一种药物输送设备,该设备包括: [0015] According to the present invention, there is provided a drug delivery device, the apparatus comprising:

[0016] 具有近端和远端的壳体; [0016] having a proximal end and a distal end of the housing;

[0017] 设计成与所述壳体接合的药物容器; [0017] The medicament container is designed to engage with the housing;

[0018] 可以向远端方向移动以输送药物的活塞杆;和 [0018] The piston rod can be moved to deliver drugs to the distal direction; and

[0019] 驱动设备,所述驱动设备用于向第一旋转方向旋转活塞杆并因此向远端方向移动所述活塞杆,以输送药物。 [0019] drive device, the drive device for the piston rod to the first rotational direction and thereby moving the piston rod in the distal direction, to deliver the drug.

[0020] 所述活塞杆包括两个螺纹区段,其中第一螺纹区段用于螺纹接合复位元件,而第二螺纹区段用于螺纹接合所述驱动设备,并且所述第一和第二螺纹区段内的螺纹相对设置。 [0020] The piston rod comprises two threaded sections, wherein a first threaded section for threaded engagement with a reset element, and the second threaded section for threaded engagement with the drive device, and the first and second Threaded opposed within the sector. 在操作状态下,所述复位元件被阻止相对于壳体旋转,所述活塞杆被阻止向近端方向移动。 In the operating state, the reset element is prevented from rotating relative to the housing, the piston rod is prevented from moving in the proximal direction. 在复位状态下,所述复位元件被允许相对于所述壳体旋转,通过向着第二旋转方向旋转所述活塞杆和所述复位元件并向近端方向移动所述活塞杆,从而将所述药物输送设备复位。 In the reset state, the reset element is allowed to rotation relative to the housing, to move toward the second rotational direction by rotating the piston rod and the reset element to the piston rod in the proximal direction, whereby the drug delivery device reset.

[0021] 根据本发明的药物输送设备设计成,在操作状态下,所述活塞杆可以利用驱动设备向着远端方向轴向移动并相对于壳体向着第一方向(第一旋转方向)旋转,以输送药物, 而所述活塞杆被阻止相对于所述壳体向着近端方向轴向移动。 [0021] The conveying device is designed, in the operating state, the piston rod driving apparatus can be used in accordance with the present invention, the drug toward the distal direction and move axially relative to the housing toward the first direction (first rotational direction), to deliver medicament, and said piston rod is prevented with respect to the axial movement of the housing towards the proximal direction.

[0022] 根据本发明,所述药物输送设备设计成,在操作状态下,所述复位元件被阻止相对于所述壳体旋转。 [0022] According to the present invention, the drug delivery device designed to be, in the operating state, the reset element is prevented from rotating relative to the housing. 优选,在操作状态下,所述复位元件被阻止相对于所述壳体进行任何运动(平移以及旋转运动)。 Preferably, in the operating state, the reset element is prevented from any housing with respect to the movement (translational as well as rotational movement). 优选,所述复位元件安装在所述壳体内,以使该复位元件被阻止在任何时候相对于所述壳体进行轴向移动,并且此外,所述复位元件仅在操作状态下被阻止旋转。 Preferably, the reset element is mounted within the housing, so that the reset element is prevented at any time with respect to the axial movement of the housing, and in addition, only the reset element is prevented from rotating in the operating state. 作为替代,所述复位元件可以安装在所述壳体内,以使所述复位元件在复位状态下, 保持可以相对于所述壳体进行旋转运动以及受限的轴向移动,并且在操作状态下,所述复位元件被阻止相对于所述壳体进行轴向移动和旋转。 Alternatively, the reset element can be mounted within the housing, so that the element is reset in the reset state, can be maintained with respect to the housing is limited rotational movement and axial movement, and in the operating state , the reset element is prevented from axially relative to the housing to move and rotate.

[0023] 此外,所述药物输送设备设计成,在复位状态下,所述活塞杆相对于所述壳体向着近端方向自由地轴向移动(同时向着另一个方向旋转——第二旋转方向)。 [0023] In addition, the drug delivery device designed to be, in the reset state, the piston rod relative to the housing in the proximal direction of the free axial movement (and toward the other direction of rotation - the second rotational direction ).

[0024] 优选,所述药物输送设备设计成,在复位状态下,所述活塞杆相对于所述壳体向着近端方向自由旋回,例如在将新药物容器(例如,新管筒或带有新管筒的管筒保持件)安装在所述设备的壳体的远端上的时候,复位所述活塞杆。 [0024] Preferably, the drug delivery device designed to be, in the reset state, the piston rod relative to the housing in the proximal direction of the free cycle, for example, new drugs in the container (for example, with a new tube or The new tube tube holder) is mounted at the distal end of the housing of the device on when reset the piston rod.

[0025] 根据本发明的优选实施方式,所述药物输送设备设计成: [0025] According to a preferred embodiment of the present invention, the drug delivery device is designed to:

[0026] 在药物容器接合所述壳体的远端时,所述复位元件处于操作状态;和 When [0026] In the distal end engaging the medicament container housing the reset element is in the operating state; and

[0027] 当药物容器从所述壳体的远端脱开时,所述复位元件处于复位状态。 [0027] When the drug container is disengaged from the distal end of the housing, the reset element in the reset state.

[0028] 根据该实施方式,用于将药物容器与所述壳体接合的运动导致复位元件移动到它相对于所述壳体旋转锁止的位置或状态。 [0028] According to this embodiment, the medicament container for engagement with the housing the reset element movement causes it to move relative to the housing to lock the rotational position or state. 可以通过下述步骤来实现这种效果,例如将复位元件移动到它与所述壳体的特征件(例如,齿或花键)或药物输送设备的另一个非旋转部件接合的位置,或者例如将另一个非旋转部件移动到它与所述复位元件接合并阻止其旋转的位置。 By the following steps to achieve this effect, such as the position of the other non-rotating member with the reset member is moved to its characteristic elements (e.g., teeth or splines) of the housing of the drug delivery device or engaged, or e.g. The other non-rotating member to move it engages with the reset element is prevented from rotation position.

[0029] 因此,本发明进一步涉及一种药物输送设备,所述设备包括: [0029] Accordingly, the present invention further relates to a drug delivery device, said apparatus comprising:

[0030] 具有远端和近端的壳体; [0030] having a distal end and a proximal end of the housing;

[0031] 设计成接合所述壳体的远端的药物容器; [0031] The medicament container is designed to engage the distal end of the housing;

[0032] 向着远端方向移动以输送药物的活塞杆;和 [0032] toward the distal direction to the piston rod drug delivery; and

[0033] 驱动设备,所述驱动设备向着第一旋转方向旋转所述活塞杆,由此向着远端方向移动所述活塞杆,用于输送药物。 [0033] drive device, the drive device toward a first rotational direction of the piston rod, thereby moving the piston toward the distal direction for medication delivery.

[0034] 所述活塞杆与复位元件螺纹接合。 [0034] The piston rod threaded engagement with the reset element. 优选,所述活塞杆包括两个螺纹区段,其中第一螺纹区段用于螺纹接合复位元件,而第二螺纹区段用于螺纹接合所述驱动设备,并且所述第一和第二螺纹区段内的螺纹相对设置。 Preferably, the piston rod comprises two threaded sections, wherein a first threaded section for threaded engagement with a reset element, and the second threaded section for threaded engagement with the drive device, and said first and second threaded disposed opposite the threaded section.

[0035] 在药物容器接合所述壳体时,所述复位元件被阻止相对于所述壳体旋转,因而所述活塞杆被阻止向着近端方向移动。 [0035] When engaging the medicament container housing the reset element is prevented from rotating relative to the housing, so that the piston rod is prevented from moving towards the proximal direction. 当药物容器从所述壳体脱开时,所述复位元件被允许相对于所述壳体旋转,通过向着第二旋转方向旋转所述活塞杆和所述复位元件,并向着近端方向移动所述活塞杆,可以将所述药物输送设备复位。 When the medication receptacle is disengaged from the housing, the reset element is allowed with respect to the housing is rotated toward the second rotational direction by rotating the piston rod and the reset element, and the movement towards the proximal direction said piston rod, the drug delivery device can be reset. 因此,在药物容器接合所述壳体时,所述设备处于操作状态,而在药物容器从所述壳体脱开时,所述设备处于复位状态。 Therefore, when the medicament container engages the housing, the device is in operation, and in the medication container disengaged from the housing, the device is in the reset state.

[0036] 根据本发明优选实施方式,药物容器设计成通过将第一接合装置与第二接合装置接合而与所述壳体的远端接合。 [0036] According to a preferred embodiment of the present invention, by the medicament container is designed to engage the first engagement means and second engagement means into engagement with the distal end of the housing. 所述第一接合装置和第二接合装置例如借助所述药物容器的运动而形成接合,所述药物容器的运动包括药物容器相对于所述壳体不存在轴向移动的旋转运动(例如,终结于旋转运动而不存在轴向移动的药物容器运动)(或者而相反,借助所述壳体的运动而形成接合,所述壳体的运动包括壳体相对于药物容器不存在轴向移动的旋转运动(例如,终结于旋转运动而不存在轴向移动的壳体运动))。 The first engagement means and second engagement means, for example by means of the movement of the medicament container is formed by joining, movement of the medicament container comprises a medicament container relative to the axial movement of the housing there is no rotational movement (e.g., end in the presence of rotational movement without axial movement of the medication container movement) (or rather the opposite, by means of the movement of the housing and into engagement, the rotational movement of said housing comprises a medicament container housing relative axial movement does not exist movement (for example, the end of the rotational movement without axial movement of the existence of a housing movement)). 所述复位元件因此可以优选在所述药物容器的旋转运动过程中进入操作状态,而同时所述药物容器不会相对于所述壳体轴向移动;或者在所述壳体的旋转运动中进入操作状态,而同时所述壳体不会相对于所述药物容器轴向移动。 The reset element can thus preferably enters the operating state of the rotational movement of the medicament container in the process, while the medication container is not moved axially relative to the housing; or enter in a rotational movement of the housing operating state, while the housing is not relative to the axial movement of the medication container.

[0037] 但是,所述药物容器可以利用本领域技术人员知悉的任何接合装置与所述壳体接合。 [0037] However, the medicament container may be joined by any means known to those skilled in engagement with the housing.

[0038] 所述药物输送设备的所述药物容器可以包括:促动装置,用于将所述复位元件带入操作状态(并优选还保持该操作状态),在操作状态下所述复位元件优选引导所述活塞杆用于输送药物。 [0038] The medicament delivery device of the medicament container may comprise: actuating means for the reset element into the operational state (and preferably also maintains the operation state), in the operating state of the reset element preferably guiding the piston rod for medication delivery. 所述壳体和所述药物容器可以利用下述运动形成接合:该运动优选包括终结于旋转运动而不存在所述促动装置相对于所述壳体的轴向移动,所述促动装置由此将所述复位元件带入操作状态。 The housing and the medication receptacle can be engaged is formed by the following movement: the movement preferably comprises a rotational movement without the presence of an end to the actuating means with respect to the axial movement of the housing, the actuating means comprises This reset element into the operational state.

[0039] 所述药物输送设备可以设计成,利用促动装置的运动,诸如旋转运动,所述促动装置与所述复位元件直接或间接相互作用,用于将所述复位元件带入操作状态,并由此将所述药物输送设备带入操作状态,用于输送药物,在所述操作状态下,所述复位元件被阻止相对于所述壳体旋转并且所述活塞杆被阻止向着近端方向移动。 [0039] The drug delivery device may be designed, the use of actuating means of the movement, such as rotational movement, the actuating means directly or indirectly interacting with the reset element for resetting the operating element into the state , and thereby the drug delivery device into the operating state, for delivering drugs, in the operating state, the reset element is prevented from rotating relative to the housing and the piston rod towards the proximal end is blocked direction.

[0040] 在本发明的优选实施方式中,所述壳体和所述药物容器的第一和第二接合装置设计成,在所述药物容器和所述壳体形成接合时,所述促动装置首先相对于所述壳体旋转并轴向移动,然后旋转而不轴向移动,由此将所述复位元件带入操作状态。 [0040] In a preferred embodiment of the present invention, the first and second engagement means housing and said drug container is designed, when the medicament container and the housing form a bond, the actuating first means with respect to the rotational and axial movement of the housing, and then rotate without axial movement, whereby the reset element into the operational state. 当所述第一和第二接合装置脱离接合时(以及因此当所述药物容器从所述壳体脱开时),所述复位元件优选离开或被带出操作状态,进入该复位元件不再引导或保持所述活塞杆的另一个位置(复位状态)。 When the first and second engagement means is disengaged (and thus when the medication container disengaged from the housing), the reset element preferably leave the state or out of the operation, entering the reset element is no longer guiding or holding the piston rod to another position (Reset).

[0041] 根据本发明优选实施方式,所述药物容器或所述药物容器的插件包括所述第一接合装置,而所述壳体或所述壳体的插件包括所述第二接合装置。 [0041] According to a preferred embodiment of the present invention, the medicament container of the medicament container or the insert includes a first engagement means and the housing or the plug housing comprises the second engagement means.

[0042] 所述第一接合装置例如可以是所述药物容器的螺纹(优选为外螺纹),而所述第二接合装置是所述壳体的接合元件或所述壳体的插件的接合元件,用来与所述药物容器的螺纹接合,其中所述药物容器的所述螺纹的远端合并到环形凹槽中,以使所述药物容器通过首先相对于所述壳体旋转并向近端移动然后仅相对于所述壳体旋转而结合所述壳体。 [0042] The first engagement means may be for example a threaded receptacle of the medicament (preferably male), and said second engagement means is engaging the engaging element of the housing member or the plug housing , for engaging with the threads of the medicament container, wherein said threaded distal end of said medication container into the annular groove, so that the medicament container relative to the housing by first rotating the proximal end to Then only the mobile phase and the combination of the housing for rotating the housing. 在所述接合运动结束时发生的单纯旋转运动利用所述接合元件沿着不存在节距(即,导程为零)的环形凹槽移动来实现。 Simple rotational movement occurs during use of the engaging movement of the engaging member along the end of the pitch is not present (i.e., zero lead) of the annular recess to move to achieve. 优选,所述环形凹槽是围绕所述药物容器的基本上管状端部的周边一部分(例如,1/6)运行的部分环形凹槽。 Preferably, the annular groove around the peripheral portion of medicament container substantially tubular end portion (e.g., 1/6) to run part of the annular groove. 作为替代,所述螺纹/环形凹槽可以是所述壳体的一部分并且所述药物容器可以包括所述接合元件。 Alternatively, the thread / annular groove can be part of the housing and the medication receptacle can comprise the engaging element. [0043] 作为替代,壳体远端例如可以设置插件,所述插件包括第二接合装置并设计成与药物容器近端的第一接合装置接合,所述插件固紧而不能旋转,但是可以相对于壳体自由地轴向移动(受限的轴向移动),其中所述插件向着远端的轴向移动受到保持装置的限制。 [0043] Alternatively, the distal end of the housing may be provided e.g. plug, the plug comprises a second engagement means and designed to engage with the first engagement means of the proximal end of the drug container, said fastening plug can not rotate, but can be relatively free to move axially within the housing (limited axial movement), wherein distal axial movement of the plug towards the holding device is restricted. 特别是,所述壳体的所述插件可以包括内螺纹作为第二接合装置来接合作为药物容器近端的外螺纹的第一接合装置,所述药物容器包括促动装置并可以在用于将所述药物容器与所述壳体接合的第一步骤中相对于所述插件和所述壳体旋转并轴向移动,并且在用于接合所述药物容器与所述壳体的第二步骤中,所述药物容器旋转的同时,所述药物容器相对于所述壳体的轴向移动被阻止,在所述第二步骤中,所述插件利用所述药物容器的旋转而向着远端方向移动。 In particular, the housing of the plug may comprise an internal thread as a second engagement means for engaging a first engagement means of the external thread of the proximal end of the medicament container, the medicament container comprises actuating means and can be used to a first step of the second step of the medication container in engagement with the housing with respect to the plug housing and the rotary and axial movement, and for the medication container in engagement with the housing , while rotating the medicament container, the medicament container relative to an axial movement of the housing is prevented, in the second step, by the rotation of the plug and the medicament container to move toward the distal direction . 所述插件可以向着远端方向移动,例如直到所述插件抵靠所述保持装置为止,或者直到所述插件的内螺纹结束为止。 The plug-in can move toward the distal direction, for example, until the plug-in against the holding until the device or the internal thread until the plug ends.

[0044] 根据本发明的优选实施方式,所述插件是带有内螺纹的移动套筒,而所述保持构件是限制所述套筒向远端轴向移动的保持环。 [0044] According to a preferred embodiment of the present invention, the plug is movable sleeve with an internal thread, and said holding means limiting the axial movement of the sleeve to the distal end of the retaining ring. 所述保持环连接到所述壳体的远端,以使其相对于所述壳体的旋转和轴向移动被阻止。 The retaining ring is attached to the distal end of the housing, so with respect to the housing rotation and axial movement is blocked. 此外,设置弹簧构件,在药物容器不与所述设备的壳体接合时,抵靠所述壳体内的近端轴向止挡装置(例如,环形肋)移动所述套筒。 In addition, a spring member, the medicament container when not engaged with the device housing, the proximal end of the housing against a stop means (e.g., an annular rib) to move axially of the sleeve stop. 所述弹簧构件优选一侧抵靠所述保持环的近端侧而另一侧抵靠所述移动套筒的远端侧。 The spring member preferably abuts the side of the proximal end of the retaining ring side and the other side against the movement of the sleeve distal end side. 所述套筒与所述壳体接合,以使其被允许线性移动但被约束不能旋转。 Engaging the sleeve with the housing, so that it is allowed to move linearly but is constrained not rotate. 当所述壳体和所述药物容器形成接合时,所述药物容器近端上的外螺纹接合所述套筒的内螺纹。 When the housing and the medication receptacle into engagement, an external thread on the proximal end of the medication receptacle engages the internal thread of the sleeve. 因此,所述药物容器旋拧入所述壳体的远端,直到所述药物容器的近端边缘或肩部抵靠所述保持环的远端侧。 Therefore, the distal end of the medication container is screwed into the housing, until the proximal edge or shoulder of the medication receptacle abuts the distal end of the retaining ring side. 这种抵靠关系阻止所述药物容器发生进一步向近端的的线性移动。 This abutting relationship prevents the occurrence of linear movement of the medicament container further to the proximal end of. 但是,允许所述药物容器进一步旋转,由此导致所述套筒抵抗所述弹簧装置的作用力而向着远端方向线性移动, 直到所述套筒抵靠所述保持环的近端侧。 However, allowing further rotation of the medication receptacle, thereby causing the sleeve against the biasing force of said spring means and linearly moved toward the distal direction until the sleeve abuts the proximal end of the retaining ring side. 所述抵靠关系终止了所述壳体与所述药物容器的接合运动。 The abutting relationship ended engagement movement of the housing and the medication container. 在接合运动结束时,所述药物容器的单纯旋转用于将复位元件带入操作状态,在该操作状态下,所述复位元件弓I导所述活塞杆用于输送药物。 At the end of the engagement movement, simple rotation of the container for the medicament into the operational state the reset element in the operational state, the reset element guides the piston rod bow I used to deliver drugs.

[0045] 在本发明的全部实施方式中,所述复位元件优选为螺母装置,所述螺母装置螺纹接合所述活塞杆,优选与所述活塞杆的外螺纹接合。 [0045] In all embodiments of the present invention, the reset element is preferably a nut means, said nut means threadably engage the piston rod, the piston rod is preferably externally threaded engagement. 根据本发明的优选实施方式,所述复位元件是与所述活塞杆螺纹接合的螺母装置,并且所述螺母装置在操作状态下与锁止装置接合,而在复位状态下与所述锁止装置脱开。 According to a preferred embodiment of the present invention, the reset element is a nut means threadedly engaged with the piston rod, and said nut means engaging with the locking means in the operational state, and in the reset state of the locking means disengaged.

[0046] 根据本发明优选实施方式,所述驱动设备包括驱动套筒,并且所述活塞杆的第二螺纹区段用于螺纹接合所述驱动套筒。 [0046] According to a preferred embodiment of the present invention, the drive device comprises a drive sleeve and the second threaded section of the piston rod of the drive sleeve for threaded engagement.

[0047] 在该实施方式中,所述药物输送设备可以设计成,所述驱动套筒螺纹接合所述活塞杆(的第二螺纹区段),并且在所述驱动套筒向着远端方向驱动所述活塞杆以输送药物时,所述驱动套筒轴向移动并且被阻止相对于所述壳体旋转,由此导致所述活塞杆向远端轴向移动并旋转。 [0047] In this embodiment, the drug delivery device may be designed, the drive sleeve threaded engagement of the piston rod (second threaded section), and driven in the distal direction toward the drive sleeve When the piston rod to drug delivery, the drive sleeve and axially movable relative to the housing is prevented from rotating, thereby causing axial movement of said piston rod distally and rotated. 在药物输送过程中,所述驱动套筒相对于所述壳体向着远端方向位移(而不旋转),导致所述驱动套筒相对于所述活塞杆向着远端方向发生位移。 In the course of drug delivery, the drive sleeve relative to the housing in the distal direction toward the displacement (without rotating), causing the drive sleeve relative to the piston rod is displaced towards the distal direction. 由于所述驱动套筒与所述活塞杆的第二螺纹区段螺纹接合,所以所述位移导致所述活塞杆向着第一旋转方向旋转。 Since the drive sleeve engaging said second threaded section of the threaded rod, thus resulting in the displacement of the piston rod toward the first rotational direction. 由于所述复位元件与所述活塞杆的第一螺纹区段螺纹接合,所以所述活塞杆的旋转运动向着远端方向旋拧所述活塞杆。 Since the reset element with the first threaded section the piston rod is threadedly engaged, so that the rotational movement of the piston toward the distal direction screwing the piston rod. 因此,所述活塞杆向远端方向推送药物容器内的活塞,由此将药物输送出药物容器。 Accordingly, the push rod in the distal direction inside the medicament container piston, whereby the drug delivery of the drug container.

[0048] 可以实现机械优势,例如,如果第二螺纹区段的螺纹(与所述驱动设备接合,优选 [0048] mechanical advantage can be achieved, for example, if the threads of the second threaded section (engagement with the drive device, preferably

9与驱动套筒接合)较之第一螺纹区段(与复位元件接合)的螺纹具有更大的节距的话。 9 engaged with the drive sleeve) than the first threaded section (engaging with the reset element) having a thread pitch greater words. 因此,根据本发明优选实施方式,所述活塞杆所具有的第一螺纹区段中的螺纹具有第一节距, 而第二螺纹区段中的螺纹具有第二节距,其中第一节距小于第二节距(第一螺纹区段中的螺纹导程小于第二螺纹区段的螺纹导程)。 Thus, according to a preferred embodiment of the present invention, a first threaded section the piston rod has a thread with a first pitch in the second threaded section having a second thread pitch, wherein the first pitch less than the second pitch (first threaded section of the thread lead less than a second threaded section of the thread lead).

[0049] 优选,根据本发明的药物输送设备包括止挡装置,所述止挡装置设计成: [0049] Preferably, the pharmaceutical delivery device of the present invention includes a stop means, the stop means is designed to:

[0050] 在剂量设定过程中,不允许所述驱动套筒相对于所述壳体轴向移动而不进行旋转;和 [0050] In the dose setting process, it does not allow the drive sleeve to move axially relative to the housing without rotation; and

[0051] 在剂量输送过程中,不允许所述驱动套筒相对于所述壳体旋转,同时允许所述驱动套筒相对于所述壳体向远端方向轴向移动。 [0051] In the course of dose delivery, the drive sleeve is not allowed with respect to the rotation of the housing, while allowing the drive sleeve relative to the housing to move axially in the distal direction.

[0052] 所述止挡装置例如可以包括离合器装置,所述离合器装置与所述驱动套筒不可旋转地接合。 [0052] The stop means may for example comprise a clutch means, said clutch means and said drive sleeve non-rotatably engaged. 优选,所述离合器装置位于所述剂量拨转套筒和所述驱动套筒之间,并且设置成将所述剂量拨转套筒和所述驱动套筒耦接和脱开。 Preferably, the clutch means in said dose dial sleeve and the drive between the sleeve and arranged to the dose dial sleeve and the drive sleeve are coupled and disengaged.

[0053] 根据本发明的药物输送设备优选包括配量机构,所述配量机构包括所述活塞杆和所述驱动设备。 [0053] The drug delivery device of the invention preferably comprises a dosing mechanism, the dosing mechanism comprises a piston rod and the drive device. 此外,所述配量机构可以包括: Additionally, the dosing mechanism may include:

[0054] 剂量拨转套筒,所述剂量拨转套筒具有与所述壳体的螺旋螺纹接合的螺旋螺纹, 所述驱动套筒可释放地耦接到所述剂量拨转套筒;和 [0054] The dose dial sleeve, the dose dial sleeve having a helical thread of the housing and engaging the helical thread of the drive sleeve releasably coupled to the dose dial sleeve; and

[0055] 离合器装置,所述离合器装置位于所述剂量拨转套筒和所述驱动套筒之间,其中: [0055] The clutch means, said clutch means in said dose dial sleeve and the drive between the sleeve, wherein:

[0056] a)当所述剂量拨转套筒和所述驱动套筒(利用所述离合器装置)耦接时,两者都被允许相对于所述壳体旋转;和 [0056] a) when the dose dial sleeve and the drive sleeve (with the clutch means) when coupled, both are allowed to rotation relative to the housing; and

[0057] b)当所述剂量拨转套筒和所述驱动套筒脱开时,所述剂量拨转套筒相对于所述壳体的旋转被允许,而所述驱动套筒相对于所述壳体的旋转不被允许,并且所述驱动套筒向着远端方向的轴向移动被允许,由此将作用力向着远端方向传递到所述活塞杆。 [0057] b) when the dose dial sleeve and the drive sleeve is disengaged, the dose dial sleeve with respect to the rotation of the housing is allowed, but with respect to the drive sleeve said rotating housing is not allowed, and the drive sleeve in the distal direction toward the axial movement is allowed, whereby the distal direction toward the force transmitted to the piston rod.

[0058] 优选,当所述剂量拨转套筒和所述驱动套筒(利用所述离合器装置)耦接时,两者都被允许相对于所述壳体旋转并轴向移动,而两者都不被允许相对于所述壳体轴向移动而不旋转(例如,通过所述剂量拨转套筒经由螺纹螺纹与所述壳体接合)。 [0058] Preferably, when the dose dial sleeve and the drive sleeve (utilizing said clutch means) when coupled, both are allowed with respect to rotation and axial movement of the housing, while the two are not allowed to move axially relative to the housing without rotation (e.g., the dose dial sleeve by engagement with the housing via a screw thread). 根据本发明的优选实施方式,所述剂量拨转套筒和所述驱动套筒在剂量设定过程中耦接,而在剂量输送过程中脱开。 According to a preferred embodiment of the present invention, the dose dial sleeve and the drive sleeve are coupled during dose setting, and disengage the dose delivery process.

[0059] 所述剂量拨转套筒和所述驱动套筒优选在所述药物输送设备复位过程中(处于复位状态)耦接。 [0059] The dose dial sleeve and the drive sleeve is preferably in the drug delivery device reset process (in the reset state) coupled. 优选,在复位状态下,所述驱动套筒不被允许轴向移动。 Preferably, in the reset state, the drive sleeve is not allowed to move axially. 作为替代并且最优选,在复位状态下,只允许所述驱动套筒进行结合有旋转运动的轴向移动(例如,所述驱动套筒经由离合器装置和剂量拨转套筒间接耦接到所述壳体的螺纹)而不允许进行不旋转地轴向移动。 Alternatively and most preferably, in the reset state, the drive sleeve is only allowed to be combined with the rotational movement of the axial movement (e.g., via the drive sleeve dial sleeve and a clutch means coupled to the dosage indirectly threaded housing) and is not allowed to move axially without rotating. 因此,在复位状态下,当(例如,由使用者)施加作用力来向着近端方向推压所述活塞杆的远端(例如,加压底脚)时,所述活塞杆连同所述复位元件向所述第二旋转方向旋转。 Therefore, in the reset state, when (for example, by the user) to apply a force in the proximal direction of the distal end of the piston rod is pushed (for example, pressing the foot), together with the return of the piston rod the second member is rotated in the direction of rotation. 由此,所述活塞杆利用所述驱动套筒和所述第二螺纹区段之间的螺纹接合作用而向着近端方向旋拧,同时所述驱动套筒并不轴向移动。 Accordingly, the use of the threaded engagement of the piston rod of the drive sleeve and the role of the second threaded section toward the proximal direction between the screwed, while the drive sleeve does not move axially.

[0060] 根据本发明优选实施方式,与所述壳体的螺旋螺纹接合的所述剂量拨转套筒的螺旋螺纹的节距(和导程)与所述活塞杆的所述第二螺纹区段中的螺纹的节距(和导程)相同。 [0060] According to a preferred embodiment of the present invention, the helical thread of the said housing and engaging the helical thread of the dose dial sleeve pitch (and lead) of the second piston rod threaded region section of the thread pitch (and lead) the same. 在这种情况下,在剂量设定过程中,所述剂量拨转套筒相对于所述壳体的位移与所述所述驱动套筒相对于所述活塞杆的位移相同。 In this case, the dose setting process, the displacement of the dose dial sleeve with respect to said housing of said drive sleeve with respect to the same displacement of the piston rod.

[0061] 在上述全部实施方式中,所述药物输送设备可以包括锁止装置,所述锁止装置不可以相对于壳体旋转,并且可以与所述复位元件接合,由此在操作状态下,锁止所述复位元件,阻止所述复位元件相对于所述壳体旋转。 [0061] In all of the above embodiments, the drug delivery device may comprise locking means, said locking means relative to the housing can not rotate and can be engaged with the reset element, whereby the operating state, locking the reset element prevents the resetting member rotating relative to the housing. 优选,所述锁止装置花键连接到所述壳体或所述壳体的插件,由此被允许轴向移动而被阻止相对于所述壳体旋转。 Preferably, the locking means is splined to the housing or the plug housing, thereby being allowed to move axially and is prevented from rotating relative to the housing. 优选,所述锁止装置仅被允许相对于壳体轴向移动受限的轴向移动。 Preferably, the locking means is only allowed limited axial movement relative to the housing to move axially. 作为替代,所述锁止装置可以固定到所述壳体,或者甚至固定到所述壳体的一部分,并因此被阻止相对于所述壳体发生任何运动。 Alternatively, the locking means may be fixed to the housing, or even a part fixed to the housing, and thus with respect to the housing is prevented from any movement.

[0062] 在操作状态下,当所述复位元件与锁止装置接合时,所述活塞杆优选被阻止向一个旋转方向旋转以及相对于所述壳体向近端方向轴向移动,但是被允许向另一个旋转方向旋转以及相对于所述壳体向远端方向轴向移动,用于输送药物。 [0062] In the operating state, when the locking means engaged with the reset element, preferably the piston rod is prevented in one rotational direction and axial movement relative to the housing in the proximal direction, but are allowed to is rotated in the other direction of rotation and axially movable relative to the housing in the distal direction for medication delivery.

[0063] 根据本发明的药物输送设备的所述复位元件或所述锁止装置可以包括与促动装置的形状相互作用的形状,用于利用所述促动装置相对于所述壳体的旋转运动(优选不存在轴向移动)来驱动所述锁止装置和所述复位元件形成接合。 [0063] The pharmaceutical of the present invention the reset element or the locking means may include a delivery device shaped and the shape of the actuating means interacting with said actuating means for the relative rotation of the housing motion (preferably absent axial movement) to drive said locking means and the reset element into engagement.

[0064] 特别是,至少一个倾斜表面可以布置在所述促动装置上,并且至少一个对应的倾斜表面可以布置在所述复位元件上或所述锁止装置上,其中所述倾斜表面形成使得,为了让所述促动装置和所述复位元件之间发生相互作用或者所述促动装置和所述锁止装置之间发生相互作用,所述倾斜表面可以沿着彼此滑动。 [0064] In particular, the at least one inclined surface may be disposed on the actuating means, and at least one corresponding inclined surface may be arranged on the reset element or on the locking means, wherein said inclined surface is formed such that , in order to allow the actuating means and the reset element or the interaction between the interaction between the actuating means and the locking means can slide along the inclined surfaces to each other.

[0065] 优选,所述促动装置包括至少一个带有倾斜表面的凸起,所述凸起固定地或可移动地布置在所述促动装置上,或者所述促动装置可以包括至少一个带有倾斜表面的斜坡, 例如利用所述促动装置相对于所述壳体向着一个方向的旋转运动,与所述复位元件或所述锁止装置相互作用,由此驱动所述复位元件和所述锁止装置形成接合。 [0065] Preferably, the actuating means comprising at least one inclined surface with at least one projection, said projection fixedly or movably arranged on the actuating means, the actuating means or may comprise with the inclined surface of the ramp, for example, using the actuating means relative to the housing toward a rotational movement direction, and the reset element or the locking means interacting, thereby driving the reset element and the said locking means into engagement.

[0066] 所述锁止装置和所述复位元件例如可以包括端面齿,当所述锁止装置和所述复位元件在操作状态下接合时,所述端面齿互锁。 [0066] the locking means and the reset element may include end tooth for example, when the locking means and the reset element engages in the operating state, the end tooth interlock. 在复位状态下,所述端面齿脱开,因此所述锁止装置和所述复位装置脱开。 In the reset state, the end tooth is disengaged, so the locking means and the reset means disengaged.

[0067] 此外,所述药物输送设备优选设计成,例如在所述药物容器从所述壳体脱开时,所述锁止装置在偏压装置的作用力作用下,从所述复位元件脱开。 [0067] In addition, the drug delivery device is preferably designed to be, for example, when the medication receptacle is disengaged from the housing, the locking means under the force of the biasing means, said reset member from removal On. 所述偏压装置优选为弹簧, 在所述药物容器从所述药物输送设备的壳体脱开时,所述弹簧迫使复位元件和锁止装置分开。 The biasing means is preferably a spring, when the medicament container of the medicament delivery device housing is disengaged from said spring forces the reset element and the locking means apart. 最优选,在所述药物容器从所述壳体的远端脱开时,所述偏压装置将所述锁止装置从所述复位元件轴向移开,由此将所述锁止装置和所述复位元件脱开。 Most preferably, when the medicament container is disengaged from the distal end of said housing, said biasing means to said locking means axially away from the reset element, whereby the locking means and The reset element disengaged.

[0068] 此外或作为替代,所述药物输送设备可以设计成,在所述药物容器从所述壳体脱开时,所述锁止装置从所述复位元件脱开,由此所述复位元件相对于所述壳体自由旋转。 [0068] Additionally or alternatively, the drug delivery device may be designed to, when the medicament container is disengaged from said housing, said locking means disengaging from the reset element, whereby the reset element freely rotatable relative to the housing. 在该实施方式中,在所述锁止装置和所述复位元件脱开时,所述复位元件不再处于操作状态, 而是处于复位状态。 In this embodiment, when the locking means and the reset element is disengaged, the reset element is no longer in operation, but in the reset state. 根据本发明优选实施方式,在所述锁止装置从所述复位元件脱开时,所述活塞杆自由地向近端移动。 According to a preferred embodiment of the present invention, when the locking means is disengaged from the reset element, the piston rod is free to move proximally.

[0069] 优选,所述药物容器是管筒保持件,所述管筒保持件设计成接收填充有药物的管筒。 [0069] Preferably, the medicament container is a cartridge holder, the cartridge holder is designed to receive the barrel filled with the drug. 所述管筒保持件设计成与所述壳体的远端接合。 The cartridge holder is designed to engage with the distal end of the housing. 作为替代,所述药物容器例如可以是管筒,该管筒具有用于接合所述壳体的第二接合装置的第一接合装置。 Alternatively, the medicament container may be for example a tube, the tube having a first engagement means for engaging second engagement means of the casing. 填充有药物的管筒优选为管状套筒,包含药物并在一端被活塞闭合,另一端被可刺穿的隔膜闭合。 Cartridge filled with medication is preferably a tubular sleeve tube containing the drug and closed by the piston at one end and the other end is closed by a pierceable septum. 当所述活塞在所述管筒内向近端移动时,药物例如通过针管配送,所述针管穿过所述隔膜并且与药物(例如,胰岛素)连通。 When the piston moves to the proximal end of the tube of the drug, for example by dispensing syringe, the needle through the membrane and the drug (eg, insulin) connectivity.

[0070] 根据本发明优选实施方式,所述药物容器(或者所述药物容器的插件或附件)以及所述壳体(或者所述壳体的插件或附件)可以另外设置有搭扣特征件,借助所述搭扣特征件,在所述药物输送设备正常使用过程中,特别是在剂量设定和药物输送过程中,所述药物容器和所述壳体保持接合。 [0070] According to a preferred embodiment of the present invention, the drug container (or the medicament container or accessory plug) and the housing (or the housing of the plug-in or accessory) may additionally be provided with snap feature pieces, characterized by said fastener member, the drug delivery device in normal use, especially during dose setting and medication delivery process, the medicament container and the housing remain engaged. 此外,在所述药物容器安全地连接到所述壳体时,所述搭扣特征件可以向使用者提供可以听到和/或可以感觉到的反馈。 In addition, the medicament container securely connected to the housing, the latch member can provide features can be heard and / or feedback to the user can feel.

[0071] 所述药物输送设备可以是笔型设备和/或注射器型设备。 [0071] The drug delivery device can be a pen-type device and / or a syringe-type device. 所述药物输送设备可以包括针管或者作为免针管设备。 The drug delivery device may comprise a needle or needle-free device.

[0072] 根据本发明的术语“药物输送设备”应该理解为单剂量或多剂量、一次性或可重复使用的设备,这种设备设计成配送一定剂量、优选多个选定剂量的药物产品,例如胰岛素、 生长激素、小分子量肝素以及它们的类似物和/或衍生物等。 [0072] According to the present invention, the term "drug delivery device" is to be understood as a single dose or multi-dose, disposable or re-usable device, the device is designed to dispensing a dose, preferably multiple selected doses of medicinal product, e.g., insulin, growth hormone, low molecular weight heparins, and their analogues and / or derivatives. 所述设备可以具备任何形状, 例如盒型或笔型。 The device may have any shape, such as a box-type or pen-type. 剂量输送可以通过机械(可选的手动)配量机构或电气配量机构或机电配量机构或蓄能配量机构诸如弹簧等来实现。 Dose delivery by a mechanical (optionally manual) dosing mechanism or electrical dosing mechanism or electro-mechanical dosing mechanism or storage dosing mechanism such as a spring or the like. 剂量选择可以通过手动机构或电子机构或机电机构来实现。 Dose selection may be achieved by a manual mechanism or electronic mechanism or electro-mechanical means. 此外,所述设备可以包含设计用于监控生理特征诸如血糖水平等的部件。 Further, the device may contain design features, such as for monitoring blood sugar levels and other physiological components. 此外,所述设备可以包括针管,或者可以是免针管设备。 Further, the apparatus may comprise a needle or may be needle-free device. 优选,术语“药物输送设备”应该理解为可重复使用的多剂量笔型设备,具有机械和手动剂量选择和剂量输送机构,该设备设计成由未接受过正式医疗培训的人员诸如病人来使用。 Officers Preferably, the term "drug delivery device" is to be understood as a multi-dose pen-type device reusable, having mechanical and manual dose selection and dose delivery mechanism, which is designed by the device without formal medical training such as patients to use. 优选,所述药物输送设备为注射器型。 Preferably, the drug delivery device is a syringe-type. 最优选,所述药物输送设备设计成输送流体药物。 Most preferably, the drug delivery device designed to deliver fluid medication.

[0073] 在本发明的语境中,术语“药物容器”应该优选理解为包含药物的管筒或管筒组件,最优选为用于接收包含药物的管筒的管筒保持件。 [0073] In the context of the present invention, the term "drug container" should preferably be understood as a tube or a tube assembly containing the drug, and most preferably a tube for receiving a drug-containing tube holder. 此外,术语“药物容器”和“管筒”和“管筒组件”在本发明的语境中可以互换使用。 In addition, the term "drug container" and "tube" and "tube assembly" in the context of the present invention may be used interchangeably. 这意味着,使用术语“药物容器”就包括了“管筒”或“管筒组件”的意思,反之亦然。 This means that using the term "drug container" including the "tube" or "tube assembly" means, and vice versa.

[0074] 根据本发明,术语“管筒保持件”应该理解为设计成容纳包含被所述药物输送设备输送的药物的药物管筒的任何部件和/或多个部件。 [0074] According to the present invention, the term "cartridge holder" should be understood to include any part designed to accommodate the medicament drug delivery device is a drug delivery tube and / or a plurality of parts. 所述管筒保持件可以具备任何形状, 例如柱状和/或管状。 The cartridge holder can have any shape, e.g., cylindrical and / or tubular. 一般来说,所述管筒保持件可以是柱状管形或柱状非管形的单体部件或多部分部件。 Generally, the tube holding the tubular member may be cylindrical or non-cylindrical member or tubular portion of the monomer component. 可以采用本领域技术人员知道的任何适当材料制作,例如透明材料。 Any suitable material may be employed known to those skilled in the production of, for example, of a transparent material. 此外,所述管筒保持件或管筒保持件的插件优选在所述管筒保持件或所述插件的远端和/或近端的外表面和/或内表面上设置有接合装置,例如螺旋螺纹或部分螺纹或卡口等,所述接合装置用于接合位于壳体、壳体插件和/或针管组件的外表面和/或内表面上的对应接合装置。 Furthermore, the tube holder or tube holder plug preferably at the distal end of the cartridge holder or the insert and / or the outer surface of the proximal end and / or provided on the inner surface of the engagement means, for example, helical threads or part threads or bayonet, etc., the engagement means for engaging in the housing, and the corresponding / outer surface of the needle tube assembly and / or the inner surface of the upper housing insert or engagement means. 在优选实施方式中,所述管筒保持件是单体管状设计,具有位于其近端的外螺纹。 In a preferred embodiment, the tube holding member is tubular single design, with an external thread at its proximal end.

[0075] 根据本发明,术语“壳体”应该优选理解为具有接合装置的外壳体(“壳体”、“主体”、“外壳”)或内壳体(“插件”、“内主体”),所述接合装置诸如螺旋螺纹、花键或本领域技术人员知道的任何其他适当装置。 [0075] According to the present invention, the term "housing" shall preferably mean a housing body having engagement means ("housing", "body", "shell") or interior housing ("plug-ins", "inner body") Any other suitable means of said engagement means such as a helical thread, spline or known to the skilled person. 所述壳体可以设计成允许安全、正确并舒适地操作所述药物输送设备或其任何机构。 The housing may be designed to allow the safe, the drug delivery device or any mechanism operating properly and comfortably. 通常,所述壳体设计成接合药物输送设备的任何内部部件(例如,配量机构、管筒、柱塞、活塞杆),用于容纳、固定、引导和/或通过限制暴露于污染物诸如液体、灰尘、脏物等而进行保护。 Typically, the housing is designed to engage any internal components of the drug delivery device (e.g., a dosing mechanism, the barrel, plunger, piston rod), to house, fix, guide, and / or by limiting the exposure to contaminants, such as liquids, dust, dirt, etc. for protection. 一般来说,所述壳体可以是管形或非管形的单体或多部分部件。 In general, the housing may be of tubular or non-tubular member monomers or portions. 所述外壳体还可以用于容纳管筒,可以从所述管筒配送许多剂量的药物产品。 The outer shell can also be used to accommodate a tube, can delivery many doses of the drug product from the tube.

[0076] 根据本发明,术语“复位元件”应该优选理解为设计成在所述复位元件以及所述药物输送设备处于操作状态时,阻止所述药物输送设备复位,并且设计成在所述复位元件以及所述药物输送设备处于复位状态时,允许所述药物输送设备复位的任何部件。 [0076] According to the present invention, the term "reset member" should preferably be understood as designed when the reset element and the drug delivery device is in operation, preventing the drug delivery device is reset, and the reset element designed to and when the drug delivery device in the reset state, allowing any member of the drug delivery device reset. 因此所述复位元件可以处于复位状态和操作状态。 Thus the reset element may be in the reset state and the operating state. 所述复位元件优选还具有在操作状态下、在药物输送过程中引导所述活塞杆的功能。 The reset element preferably also has an operating state, functions to guide the piston rod during medication delivery. 为了实现所述引导功能,所述复位元件优选包括与所述活塞杆的对应形状相互作用的形状,例如用于接合所述活塞杆的外螺纹的内螺纹,或者非环形开口,所述非环形开口用于保持具有对应的非环形形状的活塞杆或具有对应的非环形形式的区段的活塞杆。 In order to achieve the guide function of the reset element preferably comprises a shape corresponding to the shape of the piston rod interacting, e.g., internal threads for engaging the external threads of the piston rod, or a non-annular opening, said annular non- rod opening for holding the piston rod having a non-annular shape corresponding to the annular form or with a non-corresponding segment of.

[0077] 根据本发明,术语“操作状态”应该优选理解为复位元件的位置或状态,在此位置或状态时,所述复位元件阻止所述药物输送设备复位,即直接或间接阻止所述活塞杆向近端方向运动。 [0077] According to the present invention, the term "operating status" should preferably be understood as position or state of the reset element in this position or state of the reset element prevents the drug delivery device reset, which directly or indirectly prevent the piston rod in the proximal direction. 优选,所述操作状态是所述复位元件的另一位置或状态,在所述另一位置或状态时,所述复位元件引导和/或保持所述活塞杆。 Preferably, the operating state is the reset state of the element to another position or in another position or when the state, said reset member guide and / or holding the piston rod. 在所述药物输送设备用于设定剂量和输送药物时,所述复位元件以及所述药物输送设备优选处于操作状态。 When the drug delivery device for setting a dose and drug delivery, the reset element of the medication delivery device and preferably is in operation.

[0078] 根据本发明,术语“复位状态”应该优选理解为复位元件的位置和状态,在该位置和状态时,所述复位元件允许所述药物输送设备复位,即直接或间接允许所述活塞杆向近端方向运动。 [0078] According to the present invention, the term "Reset state" should preferably be understood as the position and status of the reset element in this position and status, the reset element allows the drug delivery device reset, which directly or indirectly allow the piston rod in the proximal direction. 在所述药物输送设备拆解(即,药物容器从壳体脱开)用于以填充有药物的新管筒替换空管筒时,所述复位元件优选处于复位状态。 When dismantling the drug delivery device (ie, the drug container disengaged from the housing) is used to fill the tube with a drug of new empty tube replaced, the reset element preferably in the reset state.

[0079] 根据本发明,术语“螺母装置”应该优选理解为设计成螺纹接合活塞杆,优选用作活塞杆引导件的任何部件。 [0079] According to the present invention, the term "nut means" shall preferably mean any component of the piston rod, the piston rod is preferably used as the guide member is designed as a threaded engagement. 此外,根据本发明,术语“螺母装置”应该理解为带有设置螺纹的圆形开口的任何部件,可以是单一部件或多部分部件。 Further, according to the present invention, the term "nut means" should be understood as any member provided with a threaded circular opening, can be a single component or multiple component portions. 根据本发明优选实施方式,复位元件是螺母装置。 According to a preferred embodiment of the present invention, the reset element is a nut means. 在进一步更为具体的实施方式中,在不与药物输送设备的锁止装置接合时,螺母装置相对于壳体自由旋转。 In a further more specific embodiment, when the locking means is not engaged with the drug delivery device, the nut means is free to rotate relative to the housing. 根据本发明一种实施方式,在不与药物输送设备的锁止装置接合时,螺母装置相对于所述壳体自由旋转,并固紧而不能相对于所述壳体线性轴向移动, 但是在与所述锁止装置接合时,则固紧而不能相对于所述壳体旋转以及线性轴向移动。 According to one embodiment of the present invention, when the locking means is not engaged with the drug delivery device, the nut means is free to rotate relative to the housing, and fastening can not be linear with respect to the housing to move axially, but When engaged with the locking means, the fastening can not be rotating relative to the housing and a linear axial movement. 更优选,在不与药物输送设备的锁止装置接合时,所述螺母装置自由旋转而保持相对于所述壳体进行受限的线性轴向移动,但是在与所述锁止装置接合时,被固紧而不能相对于所述壳体旋转以及线性轴向移动。 More preferably, when the locking means is not engaged with the drug delivery device, said nut means is free to rotate relative to the housing is held axially constrained to move linearly, but when engaged with the locking means, It can not be secured with respect to the rotation and linear axial movement of the housing. 在更为具体的实施方式中,所述螺母装置具有纹理表面,例如一组端面齿(锯齿、犬齿、冠齿等)或者任何其他合适的摩擦面,优选用于接合所述设备另一个部件的纹理表面,最优选接合锁止装置的纹理表面。 In a more specific embodiment, the nut means has a textured surface, such as a set of end tooth (sawtooth, canine, crown gear, etc.) or any other suitable friction surface, another component of the device is preferably used for engagement textured surface, most preferably the locking means engaging a surface texture.

[0080] 根据本发明,术语“锁止装置”应该优选理解为作为所述壳体一部分、固定到所述壳体或者与所述壳体接合或者与所述壳体的插件接合的任何部件,以便该锁止装置被阻止相对于所述壳体发生旋转运动,最优选使得所述锁止装置被允许纵向移动但是被阻止相对于所述壳体发生旋转运动。 [0080] According to the present invention, the term "locking means" shall preferably mean a part of the housing, fixed to the housing or engaged with the housing or with any member of the plug housing engage, so that the locking means is prevented from rotating with respect to the movement of the housing, most preferably such that the locking means it is allowed to move longitudinally but is prevented from rotating with respect to the movement of the housing. 在优选实施方式中,所述锁止装置具有纹理表面,例如一组端面齿(锯齿、犬齿、冠齿等)或者任何其他合适的摩擦面。 In a preferred embodiment, the locking means has a textured surface, such as a set of end tooth (sawtooth, canine, crown gear, etc.) or any other suitable friction surface. 在更优选的实施方式中,不可旋转的锁止装置设计成接合所述复位元件,由此阻止所述复位元件相对于所述壳体旋转。 In a more preferred embodiment, the non-rotatable locking means is designed to engage the reset element, thereby preventing the reset member rotating relative to the housing. 在本发明更为具体的优选实施方式中,只要药物容器(优选管筒保持件)与所述壳体接合,不可旋转的锁止装置的纹理表面就与处于操作状态的复位元件(优选螺母装置)的纹理表面接合,以阻止所述复位元件旋转。 In the present invention, more specific preferred embodiment, as long as the medicament container (preferably a cartridge holder) engaged with the housing, the textured surface of the non-rotatable locking means is in the operating state of the reset element (preferably a nut means ) textured surface engages to prevent rotation of said reset member.

[0081] 根据本发明,术语“促动装置”应该优选理解为药物输送设备的任何部件和/或药物输送设备的部件的一部分,设计成移动药物输送设备的任何其他部件与药物输送设备的另一部件和/或药物输送设备的多个部件接合和/或脱开;和/或保持药物输送设备的任何部件处于接合状态。 [0081] The present invention, the term "actuating means" shall preferably mean according to any component part of the drug delivery device and / or drug delivery device components, other drug delivery devices designed to move any other part of the drug delivery device a plurality of parts components and / or drug delivery device engagement and / or disengagement; and / or maintenance of any component of the drug delivery device in the engaged state. 优选,所述促动装置是促动锁止装置的装置,以便移动所述锁止装置与所述复位元件接合。 Preferably, the actuating means is a means for actuating the locking means to move said locking means engaging with the reset element. 作为替代,所述促动装置可以是促动所述复位元件的装置,以便移动所述复位元件与所述锁止装置接合。 Alternatively, the actuating means may be a means to reset said actuating member to move said reset member engaging with said locking means. 在本发明的优选实施方式中,所述促动装置应该形成所述药物容器近端整体的一部分,例如,所述药物输送设备的管筒保持件整体的一部分。 In a preferred embodiment of the present invention, the pro-portion of the proximal end of the drug container be formed integral actuating means, e.g., the drug delivery device of the tube holder integral part.

[0082] 根据本发明,术语“止挡装置”应该理解为药物输送设备中设计成阻止任何部件和/或多个部件至少向着一个方向轴向移动和/或旋转运动的任何特征件和/或部件。 [0082] The present invention, the term "stop means" should be understood according to at least one direction toward the axial movement and / or rotational movement of any characteristic element and / or drug delivery devices designed to prevent any parts and / or multiple components member. 在本发明的优选实施方式中,术语“止挡装置”应该理解为垂直于药物输送设备的远端-近端轴线的任何特征件(特别是垂直于药物输送设备的远端-近端轴线的任何平面表面特征件), 设计成在某一部件抵靠所述垂直特征件时,阻止该部件向一个方向轴向移动。 In a preferred embodiment of the present invention, the term "stop means" should be understood as the distal end of vertical transportation equipment in the drug - the proximal end of the axis of any of the features (in particular the vertical transportation equipment in the pharmaceutical distal - proximal axis any flat surface features pieces), when a component is designed to abut against the vertical characteristics member, the member in one direction to prevent axial movement. 根据本发明另一优选实施方式,术语“止挡装置”应该理解为提供径向或旋转止挡作用的任何特征件, 以便在某一部件的抵靠元件抵靠所述径向或旋转止挡特征件时,阻止该部件向一个方向旋转运动。 According to another preferred embodiment of the present invention, the term "stop means" should be understood to provide a radial or rotational stop feature for any member of the role, so that the abutment member by a member against the radial or rotational stop When the feature piece, prevents the component rotational movement in one direction.

[0083] 在本发明进一步的优选实施方式中,术语“止挡装置”应该理解为所述配量机构的部件(“端部止挡件”),防止设定超过药物容器中所剩药量的剂量。 [0083] In a further preferred embodiment of the present invention, the term "stop means" should be understood as components ("end stop member") of the dosing mechanism to prevent exceeding the set dose remaining in the medicament container dose. 优选,所述端部止挡件是固紧而不能旋转但是允许相对于所述壳体轴向移动的部件,并且在已经设定最终剂量时,该部件应该阻止所述配量机构的至少一个部件旋转和/或轴向移动,从而防止设定超过管筒中所剩药量的剂量。 Preferably, the end stop member is secured against rotation but allowed to move axially relative to the housing member, and when a final dose has been set, the member should block the dosing means at least one member rotation and / or axial movement, thus preventing setting than tube left in the dose of the dose. 此外,所述“端部止挡件”应该优选在其外表面上具有螺旋螺纹, 所述螺旋螺纹设计成接合配量机构的剂量拨转套筒的内螺旋螺纹或者配量机构的剂量拨转套筒的插件的内螺旋螺纹。 In addition, the "end stop" should preferably have a helical thread on its outer surface, the helical threads dose designed to engage the dose dial sleeve of the dosing mechanism internal helical thread or dosing mechanism Bozhuan internal screw thread sleeve insert. 优选,用于螺纹接合所述壳体的所述剂量拨转套筒的外螺旋螺纹的导程大于用于螺纹接合所述端部止挡件的所述剂量拨转套筒的内螺旋螺纹的导程。 Preferably, the lead for the threaded engagement of the dose dial sleeve housing is greater than the external helical thread for engaging the threaded end of the dose dial sleeve stop the internal helical thread lead.

[0084] 根据本发明,术语“接合”应该理解为借助例如花键、螺纹、咬合齿连接,优选部件的螺纹互锁(“螺纹接合”)来互锁配量机构/药物输送设备的两个或更多个部件。 [0084] According to the present invention, the term "engagement" is to be understood as a means of splines for example, threaded, snap teeth connection, preferably the interlocking threaded member ("threadedly engaged") to interlock the two dosing mechanism / medication delivery device or more components.

[0085] 根据本发明,术语“接合装置”应该优选理解为本领域技术人员知道的可以用于接合药物输送设备的两个或更多个部件的任何装置,例如完整或部分螺纹、凹槽、与螺纹和/ 或凹槽或形成卡口锁的装置咬合的接合元件。 [0085] According to the present invention, the term "engaging means" should preferably be understood to those skilled in known medicament may be any means for engaging two or more components of the delivery device, such as a complete or partial thread, groove, with threads and / or grooves or form a bayonet locking means engaging the engagement element.

[0086] 根据本发明,术语“脱开”应该理解为将配量机构/药物输送设备的两个或更多个部件解锁。 [0086] According to the present invention, the term "disengagement" is to be understood as the two dosing mechanism / drug delivery device or more components unlocked. 根据一种示例,根据本发明的“脱开”应该理解为在偏压装置的作用力作用下将配量机构/药物输送设备的两个或更多个部件解锁。 According to one example, according to the "disengagement" of the present invention it should be understood to be under the force of the biasing means of the dosing mechanism / drug delivery device of two or more components unlocked. 两个部件也可以利用设备使用者的作用力脱开,例如由病人将药物容器从壳体旋拧松开。 Two members can also use the device user's forces disengaged, for example by the patient the drug container from the housing screwed release.

[0087] 根据本发明,术语“偏压装置”应该优选理解为用于在部件和/或多个部件上施加作用力以确保所述部件和/或多个部件受迫配接(例如,接合)或受迫分开(例如,脱开) 的任何部件。 [0087] According to the present invention, the term "biasing means" shall preferably mean for applying a force on the part and / or more components to ensure that the components and / or multiple components forced mating (for example, engaging ) or any part forced apart (for example, disconnected) is. 优选,所述偏压装置可以用本领域技术人员知道的任何适当的挠性储能材料(例如,金属、橡胶或塑料)来制造并且可以表现为任何适当的形式,例如,弹簧。 Preferably, the biasing means may be known to those skilled in any suitable flexible energy storage material (e.g., metal, rubber or plastics) and may be fabricated of any suitable form performance, e.g., a spring. 在更为优选的实施方式中,所述偏压装置是弹簧部件,例如位于所述复位元件和所述锁止装置之间。 In a more preferred embodiment, the biasing means is a spring member, e.g. located between the reset element and the locking means. 在另一种优选实施方式中,所述偏压装置是弹簧部件,位于螺母装置和锁止装置之间并位于所述壳体内。 In another preferred embodiment, the biasing means is a spring member located between a nut means and a locking means and located within said housing.

[0088] 根据本发明,术语“远端”应该理解为最靠近所述设备的配送端的所述设备的端部或所述设备的部件的端部。 [0088] According to the present invention, the term "distal" should be understood as the end portion of the end member of the apparatus or the device closest to the dispensing end of the device. 优选,针管组件设置在本发明药物输送设备的所述远端,所述针管组件的针管可以插入病人皮肤用于输送药物。 Preferably, the needle assembly of the present invention is provided in the distal end of the drug delivery device, the syringe needle cannula assembly may be inserted into the patient's skin for delivery of drugs. [0089] 根据本发明,术语“近端”应该理解为最远离所述设备的配送端的所述设备的端部或所述设备的部件的端部。 [0089] According to the present invention, the term "proximal" should be understood as the end portion of the end member of the apparatus or the device farthest from the dispensing end of the device. 优选,按钮设置在本发明药物输送设备的所述近端,所述按钮可以按压以输送剂量。 Preferably, button to set the drug delivery device of the present invention, the proximal end of the button can be pressed to deliver the dose.

[0090] 根据本发明,术语“配量机构”应该理解为设计成允许使用者选择和/或设定待配送剂量和/或提供和/或传递配送药物剂量所需作用力的任何部件和/或多个部件和/或组件。 [0090] According to the present invention, the term "dosing mechanism" should be understood as designed to allow the user to select and / or set a dose to be dispensed and / or provide and / or transfer any part of the force required dose distribution and / or more components and / or components. 所述配量机构可以由机械部件和/或机电部件和/或电气部件构成。 The dosing mechanism may be composed of mechanical and / or electromechanical components and / or electrical components. 此外,所述配量机构可以由所述设备的壳体容纳或者与所述设备的壳体接合,或者可以作为独立组件。 Additionally, the dosing mechanism may be housed by the housing of the device or in engagement with the housing of the device, or may be a separate component. 本发明的所述配量机构包括活塞杆和用于向远端方向移动活塞杆以输送药物的驱动设备。 The dosing mechanism of the present invention comprises a piston rod and a piston rod for moving the drug delivery device to drive the distal direction. 优选,本发明的配量机构包括驱动套筒和剂量拨转套筒。 Preferably, the dosing mechanism of the present invention comprises a drive sleeve and the dose dial sleeve. 更优选,本发明的所述配量机构包括驱动套筒、剂量拨转套筒、离合器装置、剂量拨转手柄和按钮装置。 More preferably, the dosing mechanism of the present invention comprises a drive sleeve, a dose dial sleeve, a clutch means, a dose dial grip and a button means.

[0091] 根据本发明,术语“活塞杆”应该理解为适配成通过壳体/在壳体内操作的部件, 设计成通过药物输送设备/在药物输送设备内传递轴向移动(优选朝向远端),优选从驱动套筒向管筒的活塞传递,目的是从管筒排出/配送药物,优选可注射产品。 [0091] According to the present invention, the term "rod" is to be understood as adapted to the housing by / operating member in the housing, it is designed to pass a drug delivery device / transfer axial movement within the drug delivery device (preferably towards the distal end ), preferably to the piston tube is passed from the drive sleeve, the purpose is discharged from the tube / distribution of drugs, preferably an injectable product. 所述活塞杆可以具有挠性或不具有挠性。 The flexible piston rod may have or may not have flexibility. 活塞杆可以是简单的杆、丝杆、齿条齿轮系统的一部分、蜗轮系统的一部分等。 The piston rod can be a simple rod, screw, rack and pinion system part, a portion of the worm gear system, or the like. “活塞杆”应该进一步理解为具有圆形或非圆形截面的部件。 "Piston" should be understood to be further member having a circular or non-circular cross-section. 所述活塞杆可以用本领域技术人员知道的任何适当材料制作。 The rod may be skilled in the art know of any suitable material.

[0092] 在优选实施方式中,所述活塞杆包括至少两个,更优选两个外部和/或内部螺旋螺纹(螺纹区段)。 [0092] In a preferred embodiment, the piston rod comprises at least two, more preferably two external and / or internal helical threads (threaded sections). 在根据本发明的活塞杆的另一种优选实施方式中,第一螺旋螺纹(第一螺纹区段)位于所述活塞杆远端而第二螺旋螺纹(第二螺纹区段)位于所述活塞杆近端, 由此所述螺纹区段的所述螺纹具有相对配置。 In accordance with another located on the piston rod of the preferred embodiment of the present invention, a first helical thread (first threaded section) is located in the distal end of said piston rod and a second helical thread (second threaded section) piston the proximal end of the rod, whereby the said screw having a threaded section disposed opposite. 在另一种优选实施方式中,根据本发明的活塞杆在远端和近端包括至少两个具有相同导程和相同节距的螺纹区段。 In another preferred embodiment, the piston rod according to the present invention at a distal end and a proximal end comprises at least two threaded sections with the same lead and the same pitch. 在本发明另一种优选实施方式中,所述活塞杆的第二螺旋螺纹的导程和节距应该大于第一螺旋螺纹的导程和节距。 In another preferred embodiment of the present invention, the lead and the pitch of the second helical thread of the piston rod should be greater than the lead of the first helical thread and pitch. 更优选,所述第一和第二螺旋螺纹的螺旋螺纹的导程比率在1 : 1.01到1 : 20的范围内,甚至更优选在1 : 1到1 : 10的范围内,最优选为1 : 2.3。 More preferably, the first and second helical lead screw threads of the threaded ratio of 1: 1.01 to 1: within the range of 20, even more preferably 1: 1-1: 10 in the range, and most preferably 1 : twenty three. 优选,所述螺纹之一(第二螺纹区段的螺纹)设计成接合所述驱动套筒。 Preferably, one of the threads (the thread of the second threaded section) is designed to engage the drive sleeve. 优选,所述螺纹另一(第一螺纹区段的螺纹)设计成接合所述复位元件,更优选接合螺母装置。 Preferably, the other thread (the thread of the first threaded section) is designed to engage the reset element, more preferably a nut engaging means. 根据本发明最优选的实施方式,具有较小导程的螺纹的活塞杆的第一外螺纹区段设计成接合螺母装置的内螺纹,而具有较大导程的螺纹的活塞杆的第二外螺纹区段设计成接合驱动套筒的内螺纹。 The first section of the second outer external thread according to the present invention, the most preferred embodiment, the thread having a smaller lead is designed to engage the piston rod of the internally threaded nut means, and having a large lead of the threaded piston rod threaded section is designed to engage the drive sleeve internally threaded. 在本发明进一步的优选实施方式中,所述活塞杆设置有止挡装置,所述止挡装置设计成限制端部止挡件向近端的轴向移动。 In a further preferred embodiment of the present invention, the piston rod is provided with a stop means, said stop means designed to limit end stop member moves axially towards the proximal end. 所述止挡装置例如可以是所述活塞杆的其中一条外螺纹的起点。 The stop means may be the start of one of the external thread of the piston rod.

[0093] 根据本发明,术语“剂量拨转套筒”应该优选理解为所述药物输送设备中直接或间接用于选择/拨转待输送药物剂量的部件。 [0093] "dose dial sleeve" according to the present invention, the term should preferably be understood as the drug delivery device directly or indirectly used to select / dial unit dose of medication to be delivered. 此外或者作为替代,剂量拨转套筒设计成指示可配送产品(药物)的选定剂量。 Additionally or alternatively, the dose dial sleeve is designed to indicate to the product delivery (drug) selected dose. 这可以利用例如打印在套筒外表面上的标记、符号、数字等或者而利用计步器等来实现。 This can be used, for example printed on the outer surface of the marker sleeve, symbols, numbers, or the like and use pedometer like. 最优选,所述剂量拨转套筒利用激光打印进行标记。 Most preferably, the dose dial sleeve is marked by laser printing. 在本发明的优选实施方式中,所述剂量拨转套筒为具有基本上圆形横截面的基本上管状部件, 具有下述任一: In a preferred embodiment of the present invention, the dose dial sleeve is substantially tubular member having a substantially circular cross-section, having any of the following:

[0094] 内螺纹和外螺纹,或者 [0094] internal and external threads, or

[0095] 内螺纹,或者 [0095] internal thread, or

[0096] 外螺纹。 [0096] external threads. [0097] 优选,所述剂量拨转套筒包括外螺纹,用于接合所述壳体的内螺纹或所述壳体的插件的内螺纹。 [0097] Preferably, the dose dial sleeve comprises an external thread for threaded engagement within the internal thread of the housing or the plug housing. 优选,根据本发明的剂量拨转套筒包括具有导程的外螺旋螺纹,所述导程类似于所述驱动套筒的内螺旋螺纹的导程,优选与其相同。 Preferably, according to the present invention, the dose dial sleeve comprises an external helical thread having a lead, and the lead for the process is similar to the drive sleeve in the screw thread, preferably identical thereto. 在本发明更为具体的实施方式中, 所述剂量拨转套筒设置有多个径向延伸构件,所述径向延伸构件适配成抵靠设置在所述壳体内或所述壳体的插件内的对应的多个径向止挡件。 In the present invention, more specific embodiments, the dose dial sleeve is provided with a plurality of radially extending member, said radially extending members adapted to abut disposed within the housing or the housing a plurality of radially within the corresponding plug-in stopper. 所述径向止挡装置优选用于在剂量设定之后停止所述剂量拨转套筒进一步旋出所述壳体和/或在剂量配送之后停止所述剂量拨转套筒进一步旋入所述壳体。 Preferably said radial stop means for stopping after the dose setting the dose dial sleeve further rotation of the housing and / or stopping the dispensing of the dose after the dose dial sleeve further screwed into the housing.

[0098] 根据本发明,术语“驱动设备”应该优选理解为设计成向所述活塞杆传递作用力用来配送药物剂量的任何部件和/或多个部件和/或组件。 [0098] According to the present invention, the term "drive unit" should preferably be understood as designed to transfer force to the piston rod for dispensing the dose of any component and / or a plurality of parts and / or components. 所述驱动设备可以由机械部件和/或机电部件和/或电子部件构成。 The drive device may be composed of mechanical and / or electromechanical components and / or electronic components. 所述驱动设备可以由所述壳体容纳和/或与所述壳体接合,或者可以作为独立组件。 The drive device may be housed by the housing and / or engagement with the housing, or may be a separate component. 优选,本发明的驱动设备包括驱动套筒。 Preferably, the drive apparatus of the present invention comprises a drive sleeve. 更优选,本发明的驱动设备包括驱动套筒、离合器装置和按钮装置。 More preferably, the drive device of the present invention comprises a drive sleeve, a clutch means and a button means.

[0099] 根据本发明,术语“驱动套筒”应该优选理解为用于直接或间接向远端方向驱动所述活塞杆以便输送药物的任何部件,最优选用于直接驱动所述活塞杆。 Any member [0099] for driving the distal direction in accordance with the present invention, the term "drive sleeve" should preferably be understood directly or indirectly to the piston rod of the medication delivery, most preferably for driving the piston rod directly. 根据本发明优选实施方式,所述驱动套筒是具有基本上圆形横截面的基本上管状部件。 According to a preferred embodiment of the present invention, the drive sleeve is a substantially tubular member having a substantially circular cross-section. 在优选实施方式中,所述驱动套筒与所述活塞杆接合。 In a preferred embodiment, the drive sleeve is engaged with the piston rod. 优选,所述驱动套筒包括用于接合所述活塞杆的外螺纹的内螺纹。 Preferably, the drive sleeve comprises an internal thread for engaging the external threads of the piston rod. 所述驱动套筒进一步优选可释放地耦接到所述剂量拨转套筒,最优选通过离合器装置耦接。 The drive sleeve is further preferably releasably coupled to the dose dial sleeve, most preferably by a clutch means is coupled.

[0100] 根据本发明,术语“螺纹”或“螺旋螺纹”应该优选理解为完整或部分螺纹,例如柱状螺旋肋/凹槽,位于所述药物输送设备的部件的内表面和/或外表面上,具有基本上三角形或方形或圆形截面,这些截面设计成允许部件之间进行连续的自由旋转和轴向移动。 [0100] shall preferably mean a full or part thread, e.g., cylindrical spiral rib / groove, located at the drug delivery device of the inner surface of the member and / or the outer surface according to the present invention, the term "thread" or "helical thread" with a substantially triangular or square or circular cross-section which is designed to allow continuous free rotational and axial movement between components. 可选地,螺纹可以进一步设计成不可大修(non-overhaulable)的部件,从而阻止特定部件向一个方向旋转或轴向移动。 Alternatively, the thread may be further designed to not overhaul (non-overhaulable) member, thereby preventing the particular member in one direction of rotation or axial movement.

[0101] 根据本发明,术语“导程”应该优选理解为螺母在完整一圈内前进的轴向距离,优选“导程”应该理解为具有螺旋螺纹的部件,即配量机构的剂量拨转套筒、驱动套筒、活塞杆等在一圈内行进的轴向距离。 [0101] According to the present invention, the term "lead" shall preferably mean the axial distance a nut in a complete circle forward, preferably "lead" should be understood as a component having a helical thread that dose metering mechanism Bozhuan In a circle of axial distance traveled sleeve, drive sleeve, piston rod, etc. 因此,导程是相关部件的螺纹节距的函数。 Thus, the lead member of the thread pitch is related to a function.

[0102] 根据本发明,术语“节距”应该优选理解为螺旋螺纹上的连续轮廓之间平行于该螺旋螺纹的轴线测量的距离。 [0102] According to the present invention, the term "pitch" should preferably be understood as parallel helical thread between consecutive contours on the axis of the helical thread measuring distance.

[0103] 根据本发明,本发明的一个方面提供一种药物输送设备,用于配送药物产品,优选用于配送制剂配方(例如,溶液、悬浮液等),所述制剂配方包括从以下选择的活性化合物: 胰岛素、生长激素、小分子量肝素、它们的类似物以及它们的衍生物。 [0103] According to the present invention provides, in one aspect the present invention provides a drug delivery device for dispensing a pharmaceutical product, preferably for dispensing formulations formulations (e.g., solutions, suspensions, etc.), the formulation comprises a formulation selected from the following active compound: insulin, growth hormone, low molecular weight heparin, their analogues and their derivatives.

[0104] 本发明进一步涉及一种制造或组装根据上述实施方式之一的药物输送设备的方法。 [0104] The present invention further relates to a method of manufacturing or assembling the drug delivery device in accordance with one of the above-described embodiment. 所述方法优选包括步骤:通过接合第一接合装置与第二接合装置,将药物容器移动到与所述设备的壳体的远端接合。 The method preferably comprises steps of: engaging a first engagement means and second engagement means is moved to the distal end of the drug container with the device engaging housing. 所述药物容器与所述壳体接合的动作导致所述复位元件被带入操作状态,在所述操作状态下,所述复位元件被阻止相对于所述壳体旋转,并且因此所述复位元件阻止所述活塞杆向近端运动以及阻止所述药物输送设备复位。 Said medication container and said housing engagement action causes the reset element is brought into the operating state, in the operating state, the reset element is prevented from rotating relative to the housing, and thus the reset element prevent proximal movement of the piston rod and prevents the drug delivery device reset.

[0105] 根据本发明,还提供了根据上述药物输送设备实施方式之一的药物输送设备用于配送药物产品的用途。 [0105] The present invention also provides the use of the drug delivery device according to the above-described embodiment of the drug delivery device for dispensing a pharmaceutical product. 所述用途优选包括配送制剂配方(例如,液体药物比如溶液、悬浮液等),所述制剂配方包括从以下选择的活性化合物:胰岛素、生长激素、小分子量肝素、它们的类似物和它们的衍生物。 Said use preferably comprises dispensing Formulation (e.g., liquid drugs such as solutions, suspensions, etc.), the formulation comprises a formulation of the active compound selected from the following: insulin, growth hormone, low molecular weight heparin, their analogues and their derivatives thereof. 附图说明 Brief Description

[0106] 在不视为任何限制的前提下,本发明参照附图进行更为详细地描述,在附图中: [0106] Without any limitation considered as the premise, the present invention is described in more detail with reference to the accompanying drawings, in which:

[0107] 图Ia至Ic示出了根据本发明的药物输送设备一种实施方式处于三种不同状态的横截面视图; [0107] Figure Ia to Ic illustrate three different states in a drug delivery device according to an embodiment of the present invention is a cross-sectional view;

[0108] 图2a至2c简略示出了根据本发明一种实施方式,与锁止装置相互作用的促动装置的实施方式的三种不同状态; [0108] Figures 2a to 2c schematically illustrate one embodiment according to the present invention, three different embodiments of the state of the locking means interacting with the actuating means;

[0109] 图3示出了根据图Ia至Ic的实施方式的中央部分的横截面放大视图,示出了处于操作状态的药物输送设备的复位元件; [0109] FIG. 3 shows a cross-section of the central portion of the embodiment of FIG. Ia to Ic enlarged view showing the reset element of the medication delivery device is in the operating state;

[0110] 图4简略示出了根据本发明,具备布置形式不同的促动装置、锁止装置和复位元件的药物输送设备的不同实施方式; [0110] Figure 4 schematically shows according to the present invention, with a different arrangement of actuation means, locking means and reset element different embodiments of a pharmaceutical delivery device;

[0111] 图5示出了根据本发明的药物输送设备的另一种实施方式。 [0111] FIG. 5 shows the drug delivery device of the present invention according to another embodiment.

[0112] 附图标记 [0112] Reference numeral

[0113] 1 药物输送设备 [0113] a drug delivery device

[0114] 2 管筒保持件 [0114] 2 cartridge holder

[0115] 3 壳体 [0115] 3 housing

[0116] 3A 壳体插件 [0116] 3A housing insert

[0117] 3B 壳体插件 [0117] 3B housing insert

[0118] 4 第二接合装置 [01] The second engagement means 4

[0119] 5 第一接合装置 [0119] 5 first engagement means

[0120] 6 管筒 [0120] 6 cylinder

[0121] 7 活塞 [0121] 7 piston

[0122] 8 接合装置 [0122] 8 engaging means

[0123] 9 锁止装置 [0123] the locking means 9

[0124] 10 锁止装置的端面齿 End tooth [0124] the locking device 10

[0125] 11 复位元件/螺母装置 [0125] 11 reset element / nut arrangement

[0126] 12 螺母装置的端面齿 [0126] end tooth nut means 12

[0127] 13 螺母装置的开口 Opening nut means [0127] 13

[0128] 14 偏压装置 [0128] 14 biasing means

[0129] 15 活塞杆的第一螺纹 The first thread [0129] 15 of the piston rod

[0130] 16 活塞杆的第二螺纹 The second thread [0130] 16 of the piston rod

[0131] 17 活塞杆 [0131] 17 of the piston rod

[0132] 18 加压底脚 [0132] 18 pressurized Foot

[0133] 19 驱动套筒 [0133] 19 drive sleeve

[0134] 20 驱动套筒的凸缘 Flange [0134] 20 of the drive sleeve

[0135] 21 驱动套筒的内螺纹 Internal thread [0135] 21 of the drive sleeve

[0136] 22k 肩部 [0136] 22k Shoulder

[0137] 22B 延伸部 [0137] 22B extension

17[0138] 23 凸缘 17 [0138] 23 flange

[0139] 24 离合器 [0139] 24 clutch

[0140] 25 离合器板 [0140] 25 clutch plate

[0141] 26 偏压装置 [0141] 26 biasing means

[0142] 27 剂量拨转套筒 [0142] 27 of the dose dial sleeve

[0143] 28 端部止挡件 [0143] 28 end of the stopper

[0144] 29 离合器远端的锯齿 [0144] 29 clutch distal serrations

[0145] 30 离合器的凸缘 [0145] 30 of the clutch flange

[0146] 31 离合器近端的锯齿 [0146] 31 proximal serrated clutch

[0147] 32 挠性臂 [0147] 32 flexible arms

[0148] 33 离合器板的锯齿 [0148] 33 of the clutch plate sawtooth

[0149] 34 端部止挡件远端的凸缘 [0149] 34 stopper distal end portion of the flange

[0150] 35 旋转 [0150] 35 is rotated

[0151] 36 轴向移动 [0151] 36 to move axially

[0152] 37 螺纹 [0152] 37 Thread

[0153] 38 环形凹槽 [0153] 38 annular groove

[0154] 39 倾斜表面 [0154] 39 inclined surface

[0155] 40 窗口 [0155] 40 window

[0156] 41 剂量拨转套筒的外部螺旋螺纹 [0156] 41 of the dose dial sleeve external helical thread

[0157] 43 壳体插件的螺纹 [0157] 43 threaded plug housing

[0158] 44 剂量拨转套筒的止挡特征件 [0158] dose dial sleeve 44 features a stopper member

[0159] 45 径向延伸构件 [0159] 45 radially extending member

[0160] 46 剂量拨转手柄 [0160] 46 of the dose dial grip

[0161] 47 剂量拨转手柄的中央开口 [0161] the central opening 47 of the dose dial grip

[0162] 48 剂量拨转手柄的环形凹部 [0162] 48 of the dose dial grip annular recess

[0163] 49 按钮 [0163] 49 button

[0164] 51 按钮芯柱 [0164] 51 button on the stem

[0165] 51 按钮头部 [0165] 51 button head

[0166] 52 按钮裙部 [0166] 52 button skirt

[0167] 53 剂量拨转套筒的螺纹插件 [0167] 53 of the dose dial sleeve threaded insert

[0168] 54 端盖 [0168] 54 cover

[0169] 55 插件43的止挡特征件 Stop feature pieces [0169] 55 plug-43

[0170] 56 插件43的止挡特征件 Stop feature pieces [0170] 56 plug-43

[0171] 57 腹板 [0171] 57 Webs

[0172] 58 凹部 [0172] 58 recess

[0173] 59 近端方向 [0173] 59 in the proximal direction

[0174] 60 活塞杆上的径向止挡装置 Radial [0174] 60 on the piston rod stopper device

[0175] 63 保持装置 [0175] 63 holding means

[0176] 64 偏压装置[0177] 65 止挡装置 [0176] biasing means 64 [0177] 65 stopper device

[0178] 70 促动装置 [0178] 70 actuating means

[0179] 71 斜坡 [0179] 71 ramp

[0180] 72 倾斜表面 [0180] 72 inclined surface

具体实施方式 DETAILED DESCRIPTION

[0181] 首先参照图Ia至lc,示出了根据本发明的药物输送设备处于三个不同位置。 [0181] Referring first to FIG. Ia lc, it shows a drug delivery device in accordance with the present invention in three different positions.

[0182] 药物输送设备1包括管筒保持件2和(外部)壳体3。 [0182] The drug delivery device 1 comprises a cartridge holder 2 and the (external) of the housing 3. 优选,对壳体3喷漆。 Preferably, the housing 3 for painting. 壳体3的远端设置有插件3A,插件3A固定地连接到壳体。 The distal end of the housing 3 is provided with a plug 3A, 3A is fixedly connected to the plug housing. 插件3A设置有第二接合装置4,用于接合管筒保持件2的第一接合装置5。 Plug 3A is provided with second engagement means 4 for engaging the cartridge holder 2 first engagement means 5. 在例示实施方式中,壳体3的插件3A设置有一系列形成在插件3A内表面上的部分螺纹。 In the illustrated embodiment, the insert 3A of the housing 3 is provided with a series 3A is formed on the inner surface of the plug threaded portion. 管筒保持件2的近端设置有第一接合装置5,用于接合插件3A的第二接合装置4。 Holding the proximal end of the barrel member 2 is provided with a first engagement means 5 for engaging the plug 4 of the second engagement means 3A. 在例示实施方式中,管筒保持件2设置有螺纹,该螺纹的远端合并到形成在管筒保持件2外表面上的(部分)环形凹槽(未示出)中。 In the illustrated embodiment, the cartridge holder 2 is provided with a thread, the thread is formed into the distal end (part) annular groove cartridge holder 2 on the outer surface (not shown). 管筒保持件2借助壳体3的插件3A的第二接合装置4与管筒保持件2的第一接合装置5的接合作用而固紧在壳体3的远端内。 Tube holder 2 by means of the plug housing 3 of the second engagement means 4 and 3A cartridge holder 2 is engaging a first engagement means 5 of the role and secured at the distal end of the housing 3. 在图中所示本发明的优选实施方式中,管筒保持件2的近端进一步设置有促动装置70,促动装置设计成激活复位元件(螺母装置11)并将其锁止在操作状态(以下描述并在图3中示出)。 In the drawings a preferred embodiment of the present invention illustrated, the proximal end of the cartridge holder 2 is further provided with an actuating means 70, the actuating device is designed to activate the reset element (nut means 11) in the operating state and the lock (described below and shown in Figure 3).

[0183] 可以从中配送许多剂量的药物产品的管筒6设置在管筒保持件2中。 [0183] can barrel from many doses of the drug delivery products 6 provided in the cartridge holder 2. 活塞7保留在管筒6中。 6 piston 7 remains in the tube.

[0184] 可拆卸的端盖(未示出)可释放地保留在管筒保持件2的远端上。 [0184] a removable cover (not shown) is releasably retained in the distal end of the cartridge holder 2 is on. 优选所述端盖包括搭扣在所述端盖上的夹子。 Preferably the end cap comprises a snap clip on the cap. 也可以对所述端盖喷漆。 You can also paint on the cap.

[0185] 所述管筒保持件2的远端设置有适当的接合装置8,诸如螺旋螺纹、卡口等,用于接合适当的针管组件(未示出),以使药物从管筒6配送并注入。 [0185] The distal end of the cartridge holder 2 is provided with appropriate engagement means 8, such as a helical thread, bayonet, etc., suitable for engaging the needle assembly (not shown) so that the drug delivery from a tube 6 and injection.

[0186] 根据图Ia至Ic的药物输送设备1包括配量机构,配量机构包括活塞杆17。 [0186] comprises a piston rod 17 according to FIG. Ia to Ic of the drug delivery device a dosing mechanism, the dosing mechanism included. 活塞杆17 —般为圆形截面。 Piston rod 17 - as a circular cross section. 加压底脚18位于活塞杆17的远端。 Pressure foot 18 is located in the distal end of the piston rod 17. 加压底脚18优选以两个分开的部件制成,这两个分开的部件围绕活塞杆17的远端部分搭扣在一起。 Pressure foot 18 is preferably made in two separate parts, these two separate parts surrounding the distal end portion of the piston rod 17 snap together. 加压底脚18设置成抵靠活塞7的近端面部。 Pressure foot 18 is provided to abut the proximal face of the piston 7. 活塞杆17可以利用驱动设备向着远端方向移动,由此推压活塞7在管筒6中向着远端方向轴向移动,用于输送药物。 Rod drive device 17 can be used toward the distal direction, thereby pushing the piston 7 to move axially in the distal direction toward the tube 6 for transporting drugs. 第一螺纹15形成在活塞杆17的远端(第一螺纹区段15)。 The first thread 15 is formed at the distal end of the piston rod 17 (first threaded section 15). 第二螺纹16形成在活塞杆17的近端(第二螺纹区段16)。 The second thread 16 is formed in the proximal end of the piston rod (second threaded section 16) 17. 第一螺纹15和第二螺纹16相反设置。 The first thread 15 and second thread 16 disposed opposite. 优选第一和第二螺纹15、16至少其中之一是多头螺纹, 最优选两者都是双头螺纹。 Preferably at least one of the first and second threads 15, 16 are long thread, most preferably both are two-start thread.

[0187] 驱动设备包括驱动套筒19,驱动套筒围绕活塞杆17延伸。 [0187] The drive apparatus includes a drive sleeve 19, the drive sleeve 17 extends about the piston rod. 驱动套筒19 一般为柱状。 The drive sleeve 19 is generally cylindrical. 驱动套筒19的远端设置有径向延伸的凸缘20。 The distal end of the drive sleeve 19 is provided with a flange 20 radially extending. 螺旋凹槽(螺纹)21沿着驱动套筒19 的内表面延伸。 Helical groove (thread) 21 extends along the inner surface 19 of the drive sleeve. 活塞杆17的第二螺纹16适配成在驱动套筒19的螺旋凹槽21内工作。 The piston rod 17 of the second thread 16 adapted to drive the helical grooves 21 of the sleeve 19 within the work in.

[0188] 肩部22A和延伸部22B形成在驱动套筒19的近端处。 Shoulder 22A and the extending portion 22B [0188] formed in the proximal end of the drive sleeve 19. 延伸部22B较之驱动套筒19的剩余部分内外径缩小。 The extension portion 22B than the remainder of the drive sleeve 19 of reduced outer diameter. 延伸部22B的近端设置有径向向外指向的凸缘23。 A proximal portion 22B is provided extending radially outwardly directed flange 23.

[0189] 离合器24围绕驱动套筒19设置在驱动套筒19和端部止挡件28 (以下描述)之间。 [0189] clutch 24 is disposed about the drive sleeve 19 and the drive sleeve 19 end stop member 28 (described below) between. 离合器24定位靠近驱动套筒19的近端。 Clutch 24 is positioned near the proximal end of the drive sleeve 19. 离合器24大致为柱状并且其远端设置有一系列圆周指向的锯齿29。 Clutch 24 is generally cylindrical and has a distal end provided with a series of circumferentially directed saw teeth 29. 每个锯齿包括纵向指向的表面和倾斜表面。 Each sawtooth comprises a longitudinally directed surface and an inclined surface. 朝向离合器24的近 Nearly 24 toward the clutch

19端,定位有径向向内指向的凸缘30。 19 end, located radially inwardly directed flange 30. 离合器24的凸缘30设置在驱动套筒19的肩部22A和延伸部22B的径向向外指向的凸缘23之间。 The clutch 24 disposed between the flange 30 of the shoulder 19 in the drive sleeve radially extending portion 22A and 22B of the outwardly directed flange 23. 离合器24的近端设置有多个锯齿31。 The proximal end of the clutch 24 is provided with a plurality of serrations 31. 离合器24利用花键(未示出)键连接到驱动套筒19,以防止离合器24与驱动套筒19之间发生旋转。 24 uses a spline clutch (not shown) keyed to the drive sleeve 19 to prevent rotation between the clutch 24 and the drive sleeve 19. 离合器24设置有多个挠性臂32 (未示出),所述挠性臂接合剂量拨转套筒27 (以下说明)内表面上的多个花键。 Clutch 24 is provided with a plurality of flexible arms 32 (not shown), the flexible arm engaging the dose dial sleeve 27 (described below) a plurality of splines on the inner surface.

[0190] 离合器板25和偏压装置26位于离合器24远端与驱动套筒19的径向延伸凸缘20的近端表面之间。 [0190] biasing the clutch plate 25 and clutch means 26 is located radially distal end 24 of the drive sleeve 19 extending between the proximal surface of the flange 20. 在例示实施方式中,偏压装置26是弹簧。 In the illustrated embodiment, the biasing means 26 is a spring. 离合器板25的近端表面设置有一系列圆周指向的锯齿33。 Proximal surface of the clutch plate 25 is provided with a series of circumferentially directed saw teeth 33. 离合器板25固紧而不能相对于壳体3旋转。 The clutch plate 25 can not be secured with respect to rotation of the housing 3. 在剂量设定(以下描述)过程中,离合器板25的锯齿33与离合器24远端的锯齿29相互作用。 In the dose setting (described below) process, the clutch plate 25 is serrated distal end 33 of the clutch 24 serrations 29 interaction.

[0191] 端部止挡件28围绕驱动套筒29设置在驱动套筒19和剂量拨转套筒27之间。 [0191] the ends of the stopper member 28 about the drive sleeve 29 disposed between the drive sleeve 27 and dose dial sleeve 19. 端部止挡件28固紧而不能相对于壳体3旋转,并可以相对于壳体3自由地轴向移动。 End stop member 28 can not be secured with respect to rotation of the housing 3, and with respect to the housing 3 is free to move axially. 在端部止挡件28的远端处,设置有径向延伸的凸缘34,以接合壳体3内表面上的花键特征件(未示出)。 At the end of the distal end portion of the stopper member 28 is provided with a radially extending flange 34, to engage the splines on the member 3 wherein the inner surface of the housing (not shown). 在例示实施方式中,端部止挡件28的外表面设置有延伸端部止挡件28全部长度的螺旋凹槽(螺纹)。 In the illustrated embodiment, the end portion of the stopper member 28 is provided with an outer surface of the extending end portion of the stopper member 28 the entire length of the helical groove (thread). 所述螺旋凹槽(螺纹)与剂量拨转套筒27的螺纹插件53接合。 The helical groove (thread) and the dose dial sleeve 27 threaded insert 53 engaged. 端部止挡件28的内表面设置有多个花键特征件(未示出)。 End stop 28 of the inner surface with a plurality of spline features (not shown). 离合器板25与这些花键特征件接合,由此固紧不能相对于壳体3旋转。 The clutch plate 25 and the engagement of these spline features, thus tightening not relative to rotation of the housing 3.

[0192] 剂量拨转套筒27设置在离合器24和壳体3之间。 [0192] dose dial sleeve 27 is provided between the clutch 24 and the housing 3. 螺旋凹槽(螺纹)41围绕剂量拨转套筒27的外表面设置。 Helical groove (thread) the dose dial sleeve 41 around the outer surface 27. 壳体3设置有螺旋肋(螺纹)42,螺旋肋适配成支座在剂量拨转套筒27的螺旋凹槽(螺纹)41中。 Case 3 is provided with a helical rib (thread) 42, a spiral rib adapted to seat in the dose dial sleeve 41 of the helical groove 27 (thread). 在例示实施方式中,螺旋肋(螺纹)42形成在插件43 的内表面上。 In the illustrated embodiment, the helical rib (thread) 42 formed on the inner surface 43 of the plug. 螺纹插件43固紧而不能相对于壳体43旋转和轴向移动。 Tighten the threaded insert 43 and not 43 rotates relative to the housing and axial movement. 螺旋肋42延伸成单次扫略插件43的内表面。 Spiral rib 42 extends into a single sweeping the inner surface 43 of the plug-ins. 剂量拨转套筒27的近端设置有呈多个径向延伸构件45形式的指向向内的凸缘。 The proximal end of the dose dial sleeve 27 is provided with a plurality of radially extending flanges 45 it was in the form of inwardly directed member.

[0193] 壳体3进一步设置有窗口40 (未示出),通过该窗口可以看到剂量拨转套筒27外表面的一部分。 [0193] housing 3 is further provided with a window 40 (not shown), through the window you can see a portion of the dose dial sleeve 27 outer surface. 可以拨转的剂量的视觉标记设置在剂量拨转套筒27的外表面上。 You can dial doses of visual marker provided in the outer surface of the dose dial sleeve 27. 窗口40 方便地仅允许看到当前拨到的剂量标记。 Window 40 conveniently only allows to see the current appropriated dosage indicia. 该窗口可以设计成允许其作为放大镜来观察当前拨到的剂量的放大视觉标记。 The window can be designed to allow it as a magnifying glass to observe an enlarged visual indication of the current appropriated doses. 优选,该窗口40以透明聚合物填充。 Preferably, the window 40 is filled with a transparent polymer. 最优选窗口40是利用两组分注射模制而制成的壳体3的插件的一部分,其中具有黑色聚合物的区段包围具有透明聚合物的区段。 Most preferably the window 40 is part of the plug-in using a two-component injection molding and made of the case 3, wherein the polymer segment having a black section surrounds a transparent polymer. 所述插件不可移动地固定到所述壳体,例如借助胶带固定。 Said insert is immovably fixed to the housing, for example by means of adhesive tape.

[0194] 壳体3的螺纹插件43设置有一系列径向止挡特征件55、56 (未示出)。 [0194] 3 threaded insert 43 of the housing is provided with a series of radial stop member 55, 56 feature (not shown). 剂量拨转套筒27的远端设置有多个止挡特征件44 (未示出),所述止挡特征件44抵靠插件43的止挡特征件56,以防止剂量拨转套筒27在设定到最大剂量时更远地旋出壳体3。 The distal end of the dose dial sleeve 27 is provided with a plurality of stoppers 44 wherein (not shown), wherein said stopper member 44 abuts against the plug member 43 wherein the stopper 56 to prevent the dose dial sleeve 27 When set to the maximum dose farther to spin out of the housing 3.

[0195] 剂量拨转手柄46围绕剂量拨转套筒27近端的外表面设置。 [0195] dose dial grip 46 of the dose dial sleeve 27 around the outer surface of the proximal end. 剂量拨转手柄46的外径优选对应于壳体3的外径。 The dose dial grip 46 preferably corresponds to the outer diameter of the outer diameter of the housing 3. 剂量拨转手柄46固紧到剂量拨转套筒27,以防止两者之间发生运动。 The dose dial grip 46 secured to the dose dial sleeve 27 to prevent movement between the two. 剂量拨转手柄46设置有中央开口47。 The dose dial grip 46 is provided with a central opening 47. 位于剂量拨转手柄46近端内的环形凹部48围绕开口47延伸。 The dose dial grip 46 is located within the proximal end of the annular recess 48 extending around the opening 47.

[0196] 按钮49设置在药物输送设备1的近端处。 [0196] button 49 is provided in the proximal end of the drug delivery device 1. 在本发明的例示实施方式中,按钮49 具有大致T形截面,带有芯柱50。 In the exemplary embodiment of the present invention, the button 49 has a generally T-shaped cross section, with the stem 50. 按钮49优选相对于壳体3自由旋转。 3 button 49 is preferably free to rotate relative to the housing. 优选按钮49包含以降低摩擦材料(例如摩擦改性聚合物材料)制成的垫片(未示出),以便降低剂量输送过程中按钮和剂量拨转手柄46之间的摩擦。 Preferably the button 49 contains a washer to reduce friction material (e.g., friction modified polymer material) (not shown), in order to reduce the dose delivery and dose dial buttons during friction between the handle 46. 按钮49的芯柱50通过剂量拨转手柄46的中央开口47延伸并通过驱动套筒19的延伸部22B的内径。 The stem 50 of the button 49 by the dose dial grip 46 central opening 47 extends through the drive sleeve and the inner diameter of the extension portion 19 22B. 按钮49的芯柱50保留在驱动套筒19和离合器24内进行受限的轴向移动。 Button 49 reserves the stem 50 in the drive sleeve 19 is limited and the clutch 24 to move axially. 在例示实施方式中,按钮49的头部51大致为圆形。 In the illustrated embodiment, the button 49 of the head 51 is substantially circular. 裙边52从头部51的周边垂挂。 52 skirt hanging from the periphery of the head 51. 裙边52适配成支座在剂量拨转手柄46的环形凹部48内。 Skirt 52 is adapted to seat in the dose dial grip 46 within the annular recess 48.

[0197] 剂量拨转套筒27远端处的内表面设置有螺旋螺纹(未示出)。 The inner surface of [0197] at the distal end of the dose dial sleeve 27 is provided with a screw thread (not shown). 在例示实施方式中,剂量拨转套筒27的螺旋螺纹设置在螺纹插件53的内表面上。 In the illustrated embodiment, the helical thread of the dose dial sleeve 27 is provided on the inner surface 53 of the threaded insert. 插件53利用固紧到剂量拨转套筒27远端的端盖54保持在剂量拨转套筒27内。 Plug-53 is fastened to the dose dial sleeve 27 distal end cap 54 is maintained at the dose dial sleeve 27. 端盖54固紧而不能相对于剂量拨转套筒27发生旋转和轴向移动。 Cover 54 can not be secured with respect to the dose dial sleeve 27 rotate and move axially. 端部止挡件28的螺旋凹槽(螺纹)接合剂量拨转套筒27 的螺纹插件53。 End stop member 28 of the helical groove (thread) the dose dial sleeve 27 engages a threaded plug 53.

[0198] 药物输送设备1进一步包括螺母装置11,螺母装置是复位元件并具有位于远端表面上的一系列端面齿12和开螺纹的环形开口13。 [0198] The drug delivery device 1 further comprises a nut means 11 is reset element and nut means having a series of transverse tooth 12 and open at the distal end surface of a threaded annular opening 13. 活塞杆17的第一螺纹15穿过螺母装置11的开螺纹的环形开口13延伸并与之螺纹接合。 The first thread of the piston rod 15 through the opening 17 of the threaded ring nut means 11 and the opening 13 extends in threaded engagement therewith. 螺母装置11被阻止相对于壳体3向远端和/或近端方向发生轴向移动,例如利用壳体3内的腹板57阻止向近端方向运动。 Nut means 11 is blocked with respect to the housing 3 occurs in the distal and / or proximal axial movement direction, such as the use of the web 57 in the housing 3 to prevent the proximal direction. 腹板57可以是单独的部件或者可以形成壳体3的一部分。 Web 57 may be a separate member or a part of the housing 3 can be formed. 在图Ia至Ic所示设备中,螺母装置11处于操作状态,此时利用锁止装置9防止螺母装置11相对于壳体3发生旋转,因此防止剂量设定和剂量输送过程中活塞杆17向近端运动。 Shown in Figure Ia to Ic apparatus, nut means 11 is in operation, then the use of the locking means 9 to prevent the nut means 11 with respect to the rotation of the housing 3 occurs, thus preventing the dose setting and dose delivery process to a piston rod 17 proximal movement.

[0199] 在例示实施方式中,药物输送设备1进一步设置有锁止装置9。 [0199] In exemplary embodiments, the drug delivery device 1 is further provided with locking means 9. 锁止装置9固紧而不能相对于壳体9发生旋转运动,但是在壳体3与管筒保持件2接合或脱开时,锁止装置9 可以相对于壳体3自由地进行受限的轴向移动。 Locking means 9 can not be secured with respect to the rotational movement of the housing 9 occurs, but the housing 3 and the cartridge holder 2 engages or disengages the locking means 9 relative to the housing 3 freely restricted axial movement. 锁止装置9的近端表面上设置有一系列端面齿10,用于接合螺母装置11的端面齿12。 Set the locking device on the proximal surface 9 has a series of end tooth 10 for engaging the nut means 11 in the end face of the teeth 12. 呈弹簧形式的偏压装置14设置在锁止装置9 近端表面和壳体内的腹板57之间。 Form of a spring biasing means 14 is disposed within the housing between the surface and the web 9 of the proximal end of the locking device 57.

[0200] 在根据图Ia至Ic的所示的实施方式中,管筒保持件2 (药物容器)包括带有斜坡71的促动装置70,在管筒保持件2与壳体3连接时(后面参照图2a至2c以及3进行描述),斜坡71的倾斜表面与锁止装置9的倾斜表面72相互作用。 [0200] In the embodiment of FIG. Ia to Ic is shown, according to the tube holding member 2 (medication receptacle) 71 is included with the ramp actuating means 70, the cartridge holder 3 is connected with the housing 2 ( later with reference to Figures 2a to 2c and 3 will be described), the inclined surface of the inclined ramp 71 and the surface 72 of the locking means 9 interaction. 利用这种相互作用,锁止装置9移动到与螺母装置11接合。 With this interaction the locking means 9 is moved into engagement with the nut means 11. 由此促动装置70将螺母装置11引入操作状态。 Whereby the actuating means 70 will be introduced into the nut means 11 operating state. 这种相互作用在下面会详细描述。 This interaction will be described in detail below.

[0201] 因此,当管筒保持件2 (药物容器)与壳体3的远端接合时,复位元件11处于操作状态,而当管筒保持件2 (药物容器)从壳体3远端脱开时,复位元件11处于复位状态。 [0201] Thus, when the distal end of the cartridge holder 2 (medication receptacle) is engaged with the housing 3 the reset element 11 is in operation, and when the cartridge holder 2 (medication receptacle) off from the distal end of the housing 3 open, the reset element 11 is in the reset state.

[0202] 在操作状态下,复位元件11被阻止相对于壳体3旋转,活塞杆17被阻止向近端方向移动,而在复位状态下,允许复位元件11相对于壳体3旋转,药物输送设备可以通过向第二旋转方向旋转活塞杆17并向着近端方向移动活塞杆17而复位。 [0202] In the operational state, the reset element 11 is prevented from rotating relative to the housing 3, the piston rod 17 is prevented from moving in the proximal direction, while in the reset state, allowing the reset element 11 with respect to the third rotation of the housing, drug delivery devices can be rotated in the second rotational direction of the piston rod 17 and the piston rod 17 in the proximal direction and reset.

[0203] 下面描述根据本发明的药物输送设备1的操作。 [0203] The following describes conveying operation of the device according to the invention of drugs.

[0204] 为了拨转剂量,使用者旋转剂量拨转手柄46,从而旋转剂量拨转套筒27。 [0204] In order to dial a dose, a user rotates the dose dial grip 46, so that rotation of the dose dial sleeve 27. 在剂量拨转过程中,离合器24经由离合器24近端处的锯齿31与剂量拨转套筒27接合。 In the dose dial process, the clutch 31 and the dose dial sleeve 24 via serrations 24 at the proximal end of the clutch 27 engaged. 当离合器24与旋转着的剂量拨转套筒27接合时,由于离合器24和驱动套筒19存在花键接合,所以离合器24和驱动套筒19与剂量拨转套筒27 —起旋转。 When the clutch 24 and rotating the dose dial sleeve 27 engaged, the clutch 24 and the drive sleeve 19 spline engagement exist, so the clutch 24 and the drive sleeve 19 and dose dial sleeve 27 - starting rotation.

[0205] 可以听到和可以感觉到的正在拨转的剂量反馈由离合器板25和离合器24提供。 [0205] can hear and can feel the dose dial feedback is provided by the clutch 24 and the clutch plate 25. 这种反馈通过离合器24相对于壳体3旋转运动过程中离合器24的锯齿29滑过离合器板25的锯齿33来提供。 This feedback through a clutch 24 relative to the rotational movement of the housing 3 29 over the course of jagged sawtooth clutch plate clutch 24 33 25 to provide. 在拨转剂量过程中,离合器板25被偏压装置26向该设备的近端轴向推压,因此保证了离合器板25和离合器24的锯齿29和33保持接触。 The dose dial process, the clutch plate 25 is biased to a proximal end 26 to the means of axial pushing device, thus ensuring the clutch 25 and the clutch plate 29 and 24 of the sawtooth 33 is held in contact. 由于离合器板25被端部止挡件28内表面上的花键特征件固紧而不能旋转,端部止挡件28被固紧而不能相对于壳体旋转,所以在剂量设定过程中,离合器24相对于离合器板25旋转。 The clutch plate 25 is splined end stop member wherein the inner surface of the stopper member 28 secured against rotation, the end portion of the stopper member 28 is secured relative to the housing and can not rotate, the dose setting process, clutch 24 with respect to the clutch plate 25 rotates. 由于锯齿29和33的轮廓的原因,优选为三角形轮廓,所以离合器24的锯齿29能在离合器24旋转时滑过离合器板25的锯齿33。 Due to the sawtooth profile 29 and 33, preferably triangular profile, serrations 29 so that the clutch 24 can slide over the clutch plate 25 is serrated 33 when the clutch 24 rotates. 优选,离合器24的锯齿29与离合器板25的锯齿33的角度间隔比率使得每个齿的节距对应于传统单位剂量,等等。 Preferably, the clutch 29 and the serrations 24 of the clutch plate 25 is serrated 33 angle intervals such that each tooth pitch ratio corresponds to the conventional unit dose, and so on.

[0206] 在待配送剂量增大时,由于剂量拨转套筒经由螺纹41、42与壳体3 (的插件43)接合,所以剂量拨转套筒27旋出壳体3 (旋转运动以及向着近端的轴向移动)。 [0206] When the dose to be dispensed is increased, due to the dose dial sleeve via a threaded engagement with the housing 41, 3 (plug 43), so the dose dial sleeve 27 screwed out of the housing 3 (rotational movement and toward Axial movement of the proximal end). 剂量拨转套筒27的螺旋凹槽41以及驱动套筒19的内螺纹21具有相同的导程。 The dose dial sleeve 27 of the helical groove 41 and the internal thread 19 of the drive sleeve 21 have the same lead. 这样允许剂量拨转套筒27从壳体3延伸与驱动套筒19沿着活塞杆17的第二螺纹16向着近端方向爬行以相同的速率进行(相对于壳体3和相对于活塞杆17的旋转运动和向着近端方向的轴向移动)。 This allows the dose dial sleeve 27 of the housing 3 and the drive sleeve 19 extends along the second thread 16 of the piston rod 17 toward the proximal direction at the same rate crawl (with respect to the housing 3 and the piston rod 17 with respect to rotational movement and axial movement in the proximal direction).

[0207] 在行程极限处,剂量拨转套筒27上的径向止挡件(未示出)接合设置在壳体3的插件43上的止挡特征件56,以阻止进一步运动。 [0207] In the travel limit at the dose dial sleeve 27 radial stopper (not shown) in the housing 3 is provided on the plug-43 features a stopper member 56 to prevent further movement. 在剂量设定过程中,由于活塞杆17上的第一和第二螺纹15、16方向相反,第一螺纹15接合螺母装置11而第二螺纹16接合驱动套筒19,所以阻止活塞杆17旋转。 In the dose setting process, the piston rod 17 opposite to the first direction and the second thread 15, 16, 15 engaging a first threaded nut means 11 and the second screw 16 engages the drive sleeve 19, thus preventing rotation of the piston rod 17 .

[0208] 在剂量设定过程中,当剂量拨转套筒27旋转并向着近端方向移动时,优选被花键特征件(未示出)阻止相对于壳体3旋转的端部止挡件28向着壳体3近端轴向移动。 [0208] In the dose setting process, when the dose dial sleeve 27 rotates and moves toward the proximal direction, preferably by spline features (not shown) relative to the end of the housing to prevent rotation of the stopper 3 28 toward the proximal end of the housing 3 to move axially. 在设定可以从管筒6配送的最大剂量时,径向延伸凸缘34抵靠形成在活塞杆17上的径向止挡特装置60,阻止端部止挡件28进一步向近端轴向移动,并且阻止剂量拨转套筒27和驱动套筒19两者进一步向着设定更大剂量的方向旋转。 When the maximum possible dose from the delivery tube 6, a radially extending flange 34 abuts the set radial stop formed on the piston rod 17 special means 60 on the end stop member to prevent further axially towards the proximal end 28 movement and prevent the dose dial sleeve 27 and the drive sleeve 19 further towards setting a larger dose of both directions of rotation.

[0209] 如果使用者不小心拨转地超过期望剂量,则药物输送设备允许在不从管筒6配送药物产品的情况下,将剂量拨转下来。 [0209] If a user inadvertently dial exceeds expectations dose, the drug delivery device allows the tube 6 in the case of distribution of pharmaceutical products are not from the dose dial down. 为此,剂量拨转手柄46反向旋转。 For this reason, the reverse rotation of the dose dial grip 46. 这样导致该系统逆向动作。 This results in the system operates in reverse. 离合器24反向旋转导致离合器24和离合器板25的锯齿29和33越过彼此,以产生与减少拨转剂量对应的滴答声。 Reverse rotation clutch 24 result clutch 24 and the clutch plate 25 and 33 cross each other serrations 29, to generate a corresponding reduction of the dose dial tick. 优选,锯齿29和33如此设置,即每个锯齿的圆周跨度对应于单位剂量。 Preferably, serrations 29 and 33 are arranged such that each saw tooth corresponds to a unit dose circumferential span.

[0210] 图Ia示出了药物输送设备处于设定第一剂量之前的状态。 [0210] FIG. Ia shows a drug delivery device is in the state set before the first dose. 图Ib示出了根据图Ia 的药物输送设备处于设定了剂量的状态。 Figure Ib shows a diagram Ia drug delivery device is set doses of state. 剂量拨转套筒27正从壳体3向近端延伸。 The dose dial sleeve 27 being extend proximally from the housing 3.

[0211] 在拨转到期望剂量时,使用者通过按压按钮49而配送该剂量。 [0211] In the dial to the desired dose, the dose to be delivered through the user presses the button 49. 这样使得离合器24 相对于剂量拨转套筒27向着该设备远端轴向位移,由此将离合器24从剂量拨转套筒27脱开。 This allows the clutch 24 with respect to the dose dial sleeve 27 toward the distal end of the axial displacement of the device, whereby the clutch 24 is disengaged from the dose dial sleeve 27. 但是,离合器24保持键连接到驱动套筒19,用于旋转。 However, the clutch 24 remains keyed to the drive sleeve 19 for rotation. 因此,离合器24脱开导致剂量拨转套筒27与驱动套筒19脱开。 Therefore, the clutch 24 is disengaged cause the dose dial sleeve 27 and the drive sleeve 19 is disengaged. 在位于剂量拨转套筒27的螺旋凹槽41中的插件43的螺旋肋42的引导下,剂量拨转套筒27与相关的剂量拨转手柄46自由旋转。 Located under the guidance of the dose dial sleeve 41 of the helical groove 27 of plug 43 spiral ribs 42, the dose dial sleeve 27 and associated dose dial grip 46 to rotate freely. 在剂量输送过程中,剂量拨转套筒27向着远端方向旋回壳体3中。 In the dose delivery process, the dose dial sleeve 27 in the distal direction toward the housing 3 cycles.

[0212] 使用者按压在按钮49上的压力进一步导致离合器24向着远端方向轴向运动而不会相对于壳体3旋转。 [0212] the user presses the button 49, leading to further pressure the clutch 24 in a distal direction toward the axial movement without rotation of the housing relative to the 3. 离合器24的轴向移动抵抗偏压装置26的作用力向着远端移动离合器板25,直到离合器板25抵靠在驱动套筒19的肩部为止,并且离合器24和离合器板25接合,以使离合器24与离合器板25之间的相对旋转被阻止,从而阻止离合器24和驱动套筒19在剂量输送过程中相对于壳体3旋转。 The axial movement of the clutch 24 against the bias force means 26 to move toward the distal end of the clutch plate 25, until the clutch plate 25 abuts against the drive sleeve 19 until the shoulder, and the clutch 24 and the clutch plate 25 is engaged with the clutch relative rotation between 25 and 24 and the clutch plate is prevented, thereby preventing the clutch 24 and the drive sleeve 19 during dose delivery rotation of the housing relative to the 3. 由于离合器板25花键连接到端部止挡件28以阻止离合器板25相对于壳体3旋转,所以离合器板25、离合器24和驱动套筒19 一起向着远端行进,但是不旋转。 The clutch plate 25 is splined to the end portion of the stopper member 28 to prevent the clutch plate 25 with respect to the housing 3 is rotated, so that the clutch plate 25, the clutch 24 and the drive sleeve 19 travel together toward the distal end, but does not rotate.

[0213] 离合器M的轴向移动导致驱动套筒19向远端方向轴向移动。 Axial movement of the [0213] M resulted clutch drive sleeve 19 to move axially in the distal direction. 驱动套筒19向着远端的纵向轴向移动进一步导致(利用驱动套筒19的内螺纹21和活塞杆17的第二螺纹16)活塞杆17 (第一螺纹区段1旋转,并因此卷绕着通过螺母装置11的开口13,由此让活塞17在管筒6中前进。 The drive sleeve 19 toward the longitudinally axially distal movement further results (using the drive sleeve 19 internal thread 21 and the second thread 16 of the piston rod 17) the piston rod 17 (first threaded section 1 rotation, and therefore winding the nut means 11 through the opening 13, which allows the piston 17 forward in the tube 6.

[0214] 一旦拨转的剂量被配送,则利用从剂量拨转手柄46延伸的多个旋转止挡件(未示出)接合壳体3的插件43上的止挡特征件55而阻止剂量拨转套筒27进一步旋转。 [0214] Once the dial dose is dispensed, the use of the dose dial grip 46 from a plurality of rotary stopper (not shown) in housing insert 3 features 43 on the stopper 55 and the stop extending dose dial turn sleeve 27 further rotation. 在例示实施方式中,所述旋转止挡特征件从剂量拨转手柄46轴向延伸并具有倾斜的端面。 In the illustrated embodiment, wherein the rotation stopper member from the dose dial grip 46 extending axially and having an inclined end surface. 零点位置由所述旋转止挡特征件(未示出)的其中一个轴向延伸边缘抵靠插件43上的对应止挡件55来确定。 One of the axial zero position by the rotational stop features (not shown) extending edge 43 abuts the corresponding plug on the stopper 55 to determine.

[0215] 剂量拨转套筒27在剂量输送过程中的旋转运动导致端部止挡件观向着远端方向轴向移动,返回其位于壳体3内的初始位置。 [0215] rotational movement of the dose dial sleeve 27 during dose delivery causes the end portion of the stopper Views axial movement towards the distal direction, to return to its original position within the housing 3 is located.

[0216] 图Ic示出了配送完剂量之后的根据图Ia和Ib的药物输送设备。 [0216] FIG. Ic shows the distribution of finished dosage after Ia and Ib according to FIG drug delivery devices. 活塞杆17和管筒6内的活塞7已经向着远端方向前进。 Piston rod 17 and the tube 6 in the piston 7 has been advancing toward the distal direction. 剂量拨转套筒27和端部止挡件观相对于壳体3 处于它们的原始位置。 The dose dial sleeve 27 and the end stopper outlook relative to the housing 3 in their original location.

[0217] 当已经配送完最终剂量之后,用完的管筒6可以取出并抛弃。 [0217] When the final dose distribution has been completed, runs out of tube 6 can be removed and discarded. 为了取出管筒6,通过将第一和第二接合装置5、4脱开,将管筒保持件2从壳体3脱开。 In order to remove the tube 6, through the first and second engagement means 5,4 disengage the cartridge holder 2 is disengaged from the housing 3. 一旦管筒保持件2从壳体3脱开,则用完的管筒6可以从管筒保持件2取下,并且可以将新的管筒6放置在管筒保持件2中。 Once the cartridge holder 2 is disengaged from the housing 3, the spent tube 6 can be kept from the tube member 2 is removed, and a new tube can be placed in a 6 2 cartridge holder.

[0218] 为了重复使用药物输送设备1,通过将活塞杆17向着近端移动到其初始位置而重置该设备。 [0218] In order to reuse a drug delivery device, through the proximal end of the piston rod 17 to move toward its initial position to reset the device. 只要螺母装置11处于操作状态,则鉴于以下原因,活塞杆17向着近端的运动被阻止: As long as the nut means 11 is in the operating state, for the following reasons, the movement of the piston rod 17 in the proximal blocked:

[0219] 活塞杆17上的第一和第二螺纹15、16方向相反,第一螺纹与不可旋转的螺母装置11接合,而第二螺纹16与驱动套筒19接合,和 [0219] the piston rod 15, 16, 17 on the first and second threaded opposite direction, 11 non-rotatable engagement of the first threads of the nut means and the second thread 16 engaged with the drive sleeve 19, and

[0220] 离合器M将驱动套筒19与剂量拨转套筒27耦接并因此间接耦接到壳体的螺纹42,因此在操作状态下,离合器M形成阻止活塞杆17向着近端运动的止挡装置的一部分。 [0220] The clutch M 19 and the drive sleeve is coupled to the dose dial sleeve 27 and therefore indirectly coupled to the housing 42 of the thread, and therefore in the operating state, the clutch piston 17 M is formed to prevent movement of the stopper toward the proximal end part of the unit block.

[0221] 因此,必须将螺母装置11设置到复位状态,在这种状态下,允许螺母装置相对于壳体3旋转,以便活塞杆17可以向着近端方向移动。 [0221] Accordingly, it must be nut means 11 is provided to the reset state, in this state, allows the nut means relative to the housing 3 is rotated so that the piston rod 17 can be moved in the proximal direction.

[0222] 管筒保持件2从壳体3脱开导致锁止装置9在偏压装置14的力作用下,从螺母装置11脱开。 [0222] the cartridge holder 2 is disengaged from the housing 3 cause the locking means 9 under the force of the biasing means 14 is disengaged from the nut means 11. 然后锁止装置9不再阻止螺母装置11的旋转。 Then the locking means 9 no longer prevent rotation of the nut means 11. 因此,螺母装置11不再处于操作状态,而是处于复位状态。 Thus, the nut means 11 is no longer in operation, but in the reset state. 这样允许螺母装置11自由旋转,并因此允许活塞杆17向着近端方向旋回。 This allows free rotation of the nut means 11, and thus allow the piston rod 17 in the proximal direction of the cycle.

[0223] 为了将包含新管筒6的管筒保持件2连接到壳体3上,必须向着近端方向轴向移动活塞杆17。 [0223] In order to include the new tube holder tube 6 2 is connected to the housing 3, must axial movement of the piston rod in the proximal direction 17. 在使用者将带有管筒6的管筒保持件2向着壳体3移动时,让管筒6的活塞7抵靠活塞杆17的端部并且让管筒6的活塞7相对于壳体3向着近端移动,由此产生上述向着近端的移动。 The users will tube 6 with a tube holder 2 is moved toward the housing 3, so that the tube 6 abuts the piston 7 of the end portion of the piston rod 17 and the tube 6 so that the piston 7 with respect to the housing 3 moving towards the proximal end, thereby generating moving toward said proximal end. 作为替代,使用者例如可以利用手指向着近端方向推压活塞杆17,然后将带有管筒6的管筒保持件2连接到壳体3。 As an alternative, users can use a finger for example, pressed in the direction toward the proximal end of the piston rod 17, and then the tube 6 with the tube holder 2 is connected to the housing 3. 当处于复位状态的螺母装置11 (螺纹接合活塞杆17)相对于壳体3自由旋转时,活塞杆17自由旋转并向着近端平移,直到锁止装置9和螺母装置11接合。 When the device is in the reset state of the nut 11 (threaded engagement rod 17) with respect to the 3 free housing is rotated, the piston rod 17 is free to rotate and translate toward the proximal end until 9 and nut means 11 engage the locking device. 借助被推靠活塞杆17的加压底脚18的新管筒6的活塞7将活塞杆17推回具有的优势在于,当所述设备复位时,活塞杆17的加压底脚18已经抵靠管筒6的活塞7。 With the piston rod is pushed against the pressure foot 17 new tube 18 7 6 piston rod 17 will push back has the advantage that, when the device is reset, the piston rod 17 of the pressure foot 18 has arrived by tube 6 piston 7. 因此,活塞杆17的起动移动(以去除管筒6中的空气)可以非常小,并且因起动而导致的药物损失可以保持在最少。 Thus, the piston rod 17 to move the start (to remove air tube 6) can be very small, and losses due to the start of drug caused can be kept to a minimum.

[0224] 包含新管筒6的管筒保持件2通过将第一和第二接合装置5、4形成接合而与壳体3接合。 [0224] The new tube containing 6 tube holder 2 by the first and second engagement means 5, 4 into engagement with the housing 3 and engaging. 当管筒保持件2与壳体3形成接合时,管筒保持件2首选旋转并向着近端方向轴向移动,因为壳体3的插件3A的第二接合装置4沿着管筒保持件2的第一接合装置5的螺纹区段移动,直到第二接合装置4达到第一接合装置5的环形凹槽区段。 When the cartridge holder 3 into engagement with the housing 2, the cartridge holder 2 and the preferred rotary member to move axially toward the proximal direction, because the plug 3A of the housing 3 of the second engagement means 4 along the barrel holding member 2 a first threaded section engaging means 5 is moved until the second engagement means 4 reaches the annular groove section of the first engagement means 5. 第二接合装置4在该环形凹槽中进一步移动,导致管筒保持件2旋转而不会相对于壳体3发生轴向移动。 The second engagement means 4 is further moved in the annular groove, resulting in rotation of the cartridge holder 2 with respect to the housing 3 without the occurrence of axial movement. 因此,第一和第二接合装置5、4可以移动到利用管筒保持件2的运动而形成接合,管筒保持件2的运动结束于旋转运动,而不存在促动装置70相对于壳体3的轴向移动。 Thus, the first and second engagement means 5,4 can be moved to take advantage of movement of the cartridge holder 2 is formed engagement, movement of tube holding member 2 to the rotational movement of the end, without the presence of actuating means 70 relative to the housing 3 of axial movement. 管筒保持件2 的进一步旋转(而不发生轴向移动)导致促动装置70的斜坡71沿着锁止装置9的倾斜表面72滑动。 Holding tube is further rotated (without the risk of axial movement) causes the ramp actuating means 70 71 72 slides along the inclined surface 9 of the locking means of the member 2. 因此,锁止装置9被抵抗偏压装置14的力而向着近端方向轴向移动,直到锁止装置9的端面齿10与螺母装置11的端面齿12接合,由此将螺母装置11 (复位元件)设置于操作状态。 Thus, the locking means 9 is means 14 against the bias force and toward the proximal direction of axial movement of the locking means 9 until the end faces of the teeth 10 and the end surface of the nut means 11 engage the teeth 12, whereby the nut means 11 (reset element) provided in the operating state. 在该位置,螺母装置11固紧而不能轴向移动和旋转。 In this position, the nut and the fastening means 11 can not axially move and rotate. 在该操作状态,活塞杆17被阻止向一个旋转方向旋转以及相对于壳体3向着近端方向轴向移动,但是被允许向着另一个旋转方向旋转并相对于壳体3向着远端方向轴向移动,用于输送药物。 In this operating state, the piston rod 17 is prevented from rotating in one direction of rotation and with respect to the housing 3 to move axially toward the proximal direction, but is allowed toward the other rotational direction with respect to the axial direction of the housing 3 toward the distal end moving, for drug delivery.

[0225] 在管筒保持件2和壳体3的插件3A的搭扣特征件(未示出)接合时,管筒保持件2和促动装置70的单纯旋转运动,即将锁止装置9移动到与螺母装置11接合的运动终止。 [0225] holder 2 and the housing 3 feature Plug fastener (not shown) is engaged in the tube 3A, the tube holder 2 and the rotational movement of the actuating device 70 alone, about to move the locking means 9 to engage with the nut means 11 motion is terminated. 在该位置,促动装置70将螺母装置11保持在操作状态。 In this position, the actuating means 70 holding the nut means 11 in the operating state.

[0226] 管筒保持件2相对于壳体3的旋转运动(没有轴向移动),即将锁止装置9移动到与螺母装置11接合的运动,其优势在于,在使用药物输送设备1之前,不会在管筒6的活塞7上积累任何压力。 [0226] the cartridge holder 2 relative to the rotational movement of the housing 3 (without axial movement), is about to lock 9 mobile engagement with the nut means 11 is moved to the device, the advantage that the drug delivery device prior to use 1, 7 does not accumulate any pressure on the piston in the tube 6.

[0227] 因此,根据本发明的药物输送设备1的配量机构复位到零点(或者不输送剂量的) 位置,如图Ia所示。 [0227] Thus, according to the present invention, the drug delivery device dosing mechanism 1 is reset to zero (or no dose delivered) position, as shown in FIG Ia.

[0228] 图加至2c简略示出根据本发明一种实施方式,与锁止装置相互作用的促动装置的实施方式处于三种不同的状态。 [0228] FIG add to 2c schematically illustrates one embodiment of the invention, an embodiment of the locking means interacting actuating means in three different states.

[0229] 图加示出了两者之间发生相互作用之前的锁止装置9和促动装置70。 [0229] FIG increase shows the interaction between the two before the locking means 9 and the actuating device 70. 在所示实施方式中,促动装置70例如是药物输送设备的药物容器(例如,管筒保持件幻的一部分。 在所示实施方式中,包括促动装置70的药物输送设备的部件进一步包括与第二接合装置4 接合的第一接合装置5,第二接合装置优选为药物输送设备的壳体的一部分或者该壳体的插件的一部分。第一和第二接合装置5、4设计成为了移动包括接合装置5、4(优选为壳体和药物容器)的两个部件形成接合,这两个部件首先旋转并相对于彼此轴向移动(第一步骤),然后仅旋转而不相对于彼此轴向移动(第二步骤)。促动装置70和锁止装置9之间的相互作用仅发生在第二步骤中,即这两个部件(例如,药物容器和壳体)以及促动装置70 和锁止装置9仅相对于彼此进行旋转时。锁止装置9优选并不相对于药物输送设备的壳体旋转。 In the illustrated embodiment, the actuating means 70, for example, the drug delivery device medicament container (e.g., a portion of the barrel holding member magic. In the illustrated embodiment, the actuating means comprising the drug delivery device 70 further comprises a member of the first engagement means 5 and the second engagement means 4 for engaging the second engagement means is preferably a portion of drug delivery or the housing of the device plug housing first and second engagement means designed as a 5,4 5,4 engagement means comprises a mobile into engagement (preferably the housing and the medication receptacle) of the two members, the two first rotating member and axially movable with respect to each other (first step) and then only rotating with respect to each other without Interaction axial movement (the second step). actuating means 70 and the locking means 9 only occurs between in the second step, i.e. the two components (e.g., medicament container and housing), and actuating means 70 and the locking means 9 only rotate with respect to each other. Preferably the locking means 9 is not relative to the drug delivery device of the rotary housing.

[0230] 图加示出了第一步骤中的促动装置70和锁止装置9,即两者之间发生旋转运动(箭头3和轴向移动(箭头36)时。在该步骤中,第二接合装置4沿着以螺纹37表示的第一接合装置5的第一区段移动。螺纹37的远端合并入以一部分环形凹槽38表示的第一接合装置5的第二区段中。在该简略视图中,该环形凹槽38看起来像平直区段,因为附图表示基本上柱状部件的外表面上的视图。 [0230] FIG plus shows a locking device 70 and the first step in the actuating device 9, the rotational movement (arrow 3 and moves (arrow 36) axially between the two. In this step, the first Second engagement means 4 moves along a first threaded section 37 a first engagement means denoted 5. The distal end of the threaded portion 37 merging into an annular recess in the first engagement means 5 in the second section 38 indicated. In this schematic view, the annular groove 38 looks like a straight section because the drawing shows a view of the outer surface of a substantially cylindrical member.

[0231] 第二接合装置4是与螺纹37和环形凹槽38接合的至少一个接合元件。 [0231] The second engagement means 4 is at least one thread 37 and the engaging member 38 engages the annular groove. 所示接合元件具有平行四边形形状。 Shown engaging element has the shape of a parallelogram.

[0232] 在图示实施方式中,锁止装置9和促动装置70具有用于相互作用的特殊形状。 [0232] In the illustrated embodiment, the actuating means 9 and 70 having a special shape for interacting locking means. 促动装置包括带有倾斜表面的斜坡71,倾斜表面用于与形成三角形凹部58的锁止装置9的对应倾斜表面39相互作用。 Actuating means comprises a ramp 71 having an inclined surface, the inclined surface of the concave portion for forming a triangular inclined surface 39 corresponding to the interaction of the locking means 58 9.

[0233] 在图加中,促动装置70相对于锁止装置9的轴向移动36与旋转35相结合,导致促动装置70接近锁止装置9,直到促动装置70抵靠锁止装置9,抵靠位置为斜坡71与锁止装置9的三角形凹部58接合的位置,如图2b所示。 [0233] FIG increase in the actuating device 70 relative to the axial movement of the locking device 9 36 35 combined with the rotation, leading to the actuating device 70 near the locking means 9 until the actuating means 70 against the locking means 9, abutment position for the location and slope triangular recesses 71 of the locking means 58 engages 9, shown in Figure 2b. 在该位置,第二接合装置4已经到达第一接合装置5的螺纹37与第一接合装置5的环形凹槽38合并的点。 In this position, the second engagement means 4 has reached the first engagement means 5 threaded annular recess 38 merging point 5 of the 37 with the first engagement means. 促动装置70相对于锁止装置9的相结合的轴向移动36与旋转35 (第一接合步骤),现在切换成仅存在促动装置70相对于锁止装置9的旋转35 (第二接合步骤)。 Actuating means 70 relative to the locking means 9 in conjunction with the axial movement of rotation 36 and 35 (first engagement step) now exists only switched to actuating means 70 relative to the locking means 9 rotation 35 (second engagement step).

[0234] 在该旋转过程中,斜坡71的倾斜表面和凹部58沿着彼此滑动。 [0234] In the course of this rotation, the inclined ramp surface 71 and the recessed portion 58 of the slide along each other. 在仅存在旋转运动而不存在轴向移动的过程中,促动装置70和锁止装置9的这种相互作用向着近端方向(箭头59)轴向驱动锁止装置9(其不可以相对于(未示出)壳体旋转),如图2c所示。 In the presence of only rotational movement without axial movement during the presence of such actuating means and the locking means 70 towards the proximal end 9 of interaction direction (arrow 59) axial drive locking means 9 (which is not relative to the (not shown) rotating the casing), shown in Figure 2c. 利用锁止装置9的这种轴向移动(优选抵抗未示出的偏压装置的力),锁止装置9被驱动到与(未示出的)复位元件(例如,螺母装置)接合,从而将复位元件设置到操作状态,在此状态下复位元件阻止在利用药物输送设备设定剂量并输送药物过程中,活塞杆17向近端方向移动。 This axial movement of utilizing locking means 9 (preferably unillustrated resist the force of the biasing means), the locking means 9 is driven to a (not shown) reset element (e.g., a nut means) engages, whereby The reset element is set to the operating state, in this state the reset element prevents the use of the drug delivery device in the set dose and drug delivery process, the piston rod 17 moves in the proximal direction. 锁止装置9和复位元件接合,例如可以通过锁止装置9的(未示出的)端面齿和复位元件互锁来实现。 Locking means 9 and the reset element engage, for example by locking means (not shown) of the end face of the gear 9 and the reset element to achieve interlocking.

[0235] 图3示出了根据图Ia至Ic的实施方式的中央部分的横截面放大视图,示出了药物输送设备的复位元件处于操作状态。 [0235] FIG. 3 shows a cross-section of FIG. Ia to Ic central portion of an embodiment of an enlarged view showing the reset element of the medication delivery device is in the operating state.

[0236] 药物输送设备的管筒保持件2利用第一接合装置5与第二接合装置4 (未示出) 接合而连接到药物输送设备的壳体3。 [0236] Drug delivery device 2 cartridge holder 5 with the first engagement means and second engagement means 4 (not shown) engaging the drug delivery device is connected to the housing 3. 管筒保持件2包括第一接合装置5,而壳体3的插件3A包括第二接合装置4。 The cartridge holder 2 comprises the first engagement means 5, and the plug 3A of the housing 3 comprises the second engagement means 4. 两部分加压底脚18安装到活塞杆17的远端,并抵靠药物管筒6 的活塞7。 Two-part foot pressure rod 18 is mounted to the distal end 17, and against drug cartridge 6 piston 7.

[0237] 根据该实施方式,管筒保持件2包括促动装置70,促动装置包括具有倾斜表面的斜坡71,倾斜表面71用于与锁止装置9的对应倾斜表面72相互作用。 [0237] According to this embodiment, the cartridge holder 2 comprises actuation means 70, the actuating means comprises a ramp 71 having an inclined surface, the inclined surface 71 for the locking means 72 corresponding to the inclined surface 9 of the interaction. 锁止装置9与螺母装置11接合,螺母装置是处于操作状态的复位元件,用于阻止活塞杆17向近端移动。 Locking means 9 and the nut means 11 is engaged, the nut means is in the operating state of the reset element for preventing the piston rod 17 moves proximally. 促动装置70的斜坡71的末端被推靠锁止装置9的远端表面,从而将螺母装置11保持在操作状态。 End of the actuating means 70 of the ramp 71 is pushed by the distal end surface of the locking means 9, thereby holding the nut means 11 in the operational state. 锁止装置9的端面齿10与螺母装置11的端面齿12接合。 End tooth 10 of the locking means 9 and the end face of the nut means 11 engage the teeth 12. 利用螺母装置11与锁止装置9接合,阻止了螺母装置11相对于壳体3发生旋转。 9 engaged by a nut means 11 and the locking means to prevent the nut means 11 from rotating relative to the housing 3. 螺母装置11与活塞杆17的第一螺纹15形成螺纹接合。 Nut means 11 and the piston rod 17 of the first thread 15 is formed threaded engagement. 利用所述螺纹接合以及活塞杆17的(相反设置的)第二螺纹16与(未示出的)驱动套筒接合,只要螺母装置11处于操作状态,就能阻止活塞杆17向近端方向移动。 And using said threaded engagement (oppositely disposed) second thread 16 (not shown) drive sleeve engages, as long as the nut means 11 is in operation, can prevent the piston rod 17 of the piston rod 17 moves in the proximal direction . 偏压装置14设置成在管筒保持件2从壳体3 (未示出)脱开时,将螺母装置11和锁止装置9推开。 Biasing means 14 is arranged at the cartridge holder 2 from the housing 3 (not shown) is disengaged, the push nut means 9 and the locking means 11.

[0238] 图4简略示出了根据本发明的药物输送设备的不同实施方式,具备布置形式不同的促动装置和复位元件。 [0238] FIG. 4 schematically shows a different embodiment of the drug delivery device of the present invention, with a different arrangement of the actuating means and the reset element. [0239] 促动装置70包括斜坡71,而药物容器2包括带有螺纹区段37和环形凹槽38的第一接合装置5。 [0239] actuating means 70 comprises a ramp 71, while the medicament container 2 comprises a threaded section 37 and the annular groove 38 of the first engagement means 5. 复位元件11具有倾斜表面39,该倾斜表面与促动装置70的斜坡71相互作用。 Reset element 11 has an inclined surface 39, the inclined ramp surface 71 and actuating means 70 interacting. 在第二接合步骤中,促动装置70相对于壳体3旋转运动的过程中,当斜坡71的倾斜表面和复位元件11彼此抵靠并沿着彼此滑动时,复位元件11被推靠锁止装置9,由此复位元件11的端面齿12接合锁止装置9的端面齿10。 In the second joining step, the actuating means 70 relative to the rotational movement of the process of the case 3, when the inclined surface 71 of the ramp and the reset element 11 against one another and slide along each other, the reset element 11 is pushed against the locking means 9, the end face of the reset element 11 thereby engaging the end face of the gear teeth 12 of the locking means 9 10. 该实施方式的锁止装置9并不是必须为单独部件。 The embodiment of locking means 9 is not necessarily a separate component. 它也可以是壳体3的一部分。 It may also be part of the housing 3.

[0240] 图5示出了根据本发明的药物输送设备的另一种实施方式。 [0240] FIG. 5 shows the drug delivery device of the present invention according to another embodiment.

[0241] 根据图5的药物输送设备1包括管筒保持件2和(外部)壳体3。 [0241] The drug delivery device of Figure 5 comprises a cartridge holder 2 and a (exterior) housing 3. 壳体3的远端设置有插件3B,插件;3B设计成接合管筒保持件2的近端。 The distal end of the housing 3 is provided with a plug 3B, plug; 3B designed to engage the proximal end of tube holding member 2. 插件;3B固紧而不能相对于壳体3旋转,但是可以相对于壳体3自由地轴向移动。 Plug; 3B can not be secured with respect to rotation of the housing 3, but with respect to the housing 3 is free to move axially. 插件:3B轴向移动的范围受到保持装置63 的限制,保持装置63与壳体3接合并固紧而不能相对于壳体3轴向移动也不能旋转。 Widget: 3B axially movable range restricted holding means 63, holding means 63 engages with the housing 3 and fastened 3 can move axially relative to the housing can not be rotated.

[0242] 插件;3B的内表面设置有第二接合装置4。 [0242] plug; 3B of the inner surface is provided with second engagement means 4. 第二接合装置4可以是本领域技术人员知道的任何适当装置,诸如卡口、螺旋螺纹等。 The second engagement means 4 may be any suitable means known to the skilled person, such as a bayonet, helical thread and the like. 优选,第二接合装置4是螺旋螺纹,并对应于管筒保持件2近端的第一接合装置5,第一接合装置5优选也是螺旋螺纹。 Preferably, the second engagement means 4 is a helical thread and corresponds to the cartridge holder 2 engages the proximal end of the first means 5, the first engagement means 5 is preferably a helical thread.

[0243] 在所示本发明实施方式中,管筒保持件2的近端进一步设置有促动装置(未示出),该促动装置设计成激活复位元件(未示出)并将其锁止在操作状态。 [0243] In the illustrated embodiment of the present invention, the proximal end of the cartridge holder 2 is further provided with actuating means (not shown), the actuating device is designed to activate the reset element (not shown) and the lock In the operation stop state.

[0244] 偏压装置64设置在保持装置63的近端面和插件的远端面之间。 [0244] biasing means 64 is disposed between the distal end surface of the holding means 63 of the proximal surface and plug-ins. 偏压装置64 可以用本领域技术人员知道的任何适当挠性材料制造,诸如不锈钢、橡胶等,并且可以呈现任何适当形式,诸如弹簧、隔件等。 Biasing means 64 may be known to those skilled in the manufacture of any suitable flexible material, such as stainless steel, rubber or the like, and may be presented in any suitable form, such as a spring, spacer and the like. 在本发明的例述实施方式中,偏压装置64是波状弹簧。 In one embodiment of the invention described embodiment, the biasing means 64 is a wave spring. 偏压装置64设计成在管筒保持件2不与壳体3接合时,保证插件:3B不抵靠保持装置63。 Biasing means 64 is designed at the cartridge holder 2 is not engaged with the housing 3, to ensure widget: 3B does not abut the retaining means 63.

[0245] 该药物输送设备的其他部件不再详细描述,但是优选类似于以上参照图Ia至Ic 所述的部件。 [0245] Other components of the drug delivery device not described in detail, but is preferably similar to that described above with reference to FIG. Ia Ic said member.

[0246] 现在描述根据本发明的药物输送设备的操作。 [0246] Now the operation of the drug delivery device according to the present invention.

[0247] 剂量拨转和剂量配送例如可以采用类似以上参照图Ia至Ic所述方式工作。 [0247] dial dose and dose distribution than for example a similar manner as described with reference to FIG. Ia to Ic work.

[0248] 当达到最终剂量配送位置时,可以取出并抛弃用完的管筒。 [0248] When it reaches a final dose dispensing position, you can remove and discard the used tube. 为了取出管筒,管筒保持件2从壳体3脱开,优选管筒保持件2从壳体3旋拧下来。 In order to remove the tube, tube holder 2 is disengaged from the housing 3, preferably the cartridge holder 2 from the housing 3 is screwed down. 一旦管筒保持件2从壳体3 脱开,则可以从管筒保持件2取出管筒,并可以将新的管筒放置在管筒保持件2中。 Once the cartridge holder 2 is disengaged from the housing 3, you can remove the tube holder 2 from the tube, and can be placed in a new tube 2 in the cartridge holder.

[0249] 将管筒保持件2从壳体3脱开,导致所述设备的(未示出的)复位元件例如利用锁止装置在偏压装置的力的作用下从复位元件脱开,而离开其操作状态。 [0249] The cartridge holder 2 is disengaged from the housing 3, resulting in the device (not shown) for example, using the reset element locking means under the force of the biasing means disengaging from the reset element, and leaving its operation. 这样做例如允许复位元件自由旋转,并因此活塞杆可以向近端方向移动,用于复位所述设备。 This example allows the reset element to rotate freely and therefore the piston rod can be moved in the proximal direction for resetting the device.

[0250] 在管筒保持件2取下之后,由于存在偏压装置64施加的力,所以插件;3B向着近端方向离开壳体3的远端(离开保持装置63)受限的距离。 [0250] After the cartridge holder 2 removed, due to the presence of the force exerted by the biasing means 64, so that plug; 3B toward the proximal direction away from the distal end of the housing 3 (away from the retaining means 63) a limited distance.

[0251] 为了将管筒保持件2连接到壳体3上,活塞杆相对于壳体3向近端方向轴向移动。 [0251] In order to connect the cartridge holder 2 to the housing 3, the piston rod 3 to move axially relative to the housing in the proximal direction. 在管筒保持件2连同管筒向壳体3移动时,新的管筒的活塞抵靠活塞杆端部并相对于壳体3向近端移动,由此导致了上述向近端方向的移动。 In moving along with the barrel 3 is moved to the housing, the piston of the new cartridge abuts the piston rod tube end portion with respect to the housing 3 is moved proximally, thereby resulting in the proximal direction of said cartridge holder 2 . 由于复位元件尚未处于操作状态,所以活塞杆向近端自由平移,直到复位元件处于操作状态,例如直到锁止装置和复位元件接合。 Not since the reset element in the operational state, the piston rod free to translate proximally until the reset element in an operational state, e.g., until the locking means and the reset element engage. 利用被推靠活塞杆的加压底脚的新管筒的活塞将活塞杆推回,其优势在于,活塞杆的加压底脚在所述设备复位时已经抵靠管筒的活塞。 The use of a piston rod is pushed against the pressure foot of new tube of the piston rod is pushed back, the advantage that the pressure foot rod in the device has been reset piston against the tube. 因此,活塞杆的起动运动(以去除管筒中的空气)可以非常小,并且因起动导致的药物损失可以保持最少。 Therefore, starting the movement of the piston rod (to remove the tube in the air) can be very small, and the drug can lead to losses due to start kept to a minimum. [0252] 包含新管筒的管筒保持件2然后与壳体接合,优选螺纹接合。 [0252] tube containing the new tube holder 2 and then engaged with the housing, preferably threaded engagement. 随着管筒保持件2 移动到与壳体3接合,位于管筒保持件2近端的第一接合装置5与插件;3B的第二接合装置接合。 With the cartridge holder 2 is moved into engagement with the housing 3, is located in the cartridge holder with a first engagement means 5 of the proximal end of plug 2; 3B engaging the second engagement means. 管筒保持件2被允许旋转并向近端方向轴向移动(第一接合步骤)直到位于管筒保持件2上的止挡装置65 (例如,环形外周缘)抵靠保持装置63为止。 The cartridge holder 2 is allowed to rotate and to axial movement in the proximal direction (first engagement step) until stop located tube holding means 65 on member 2 (e.g., an annular outer peripheral edge) against the holding means 63 so far. 止挡装置65阻止管筒保持件2发生进一步轴向移动,但是允许管筒保持件2旋转(第二接合步骤)。 Stop means 65 prevents the cartridge holder 2 is further axial movement occurs, but allows rotation of the cartridge holder 2 (second engagement step). 随着管筒保持件2进一步旋转,插件:3B抵抗偏压装置64的力向着壳体3的远端以及向着保持装置63轴向移动。 With further rotation of the cartridge holder 2 pieces, plug-ins: 3B force against the bias means 64 toward the distal end of the housing 3 and the holding means 63 toward the axial movement.

[0253] 管筒保持件2的这种单纯旋转另外导致激活装置将复位元件设置到操作状态(未示出),例如利用锁止装置抵抗偏压装置的力向近端方向轴向移动,直到锁止装置的端面齿接合复位元件的端面齿。 [0253] the cartridge holder 2 this simple rotation of the other leads to the activation means is set to the operating state reset member (not shown), such as the use of the locking means against the force of the biasing means to move axially in the proximal direction, until end tooth locking means joining side tooth reset element.

[0254] 因此,驱动机构被复位到零点(或者不输送剂量)位置。 [0254] Thus, the drive mechanism is reset to zero (or no dose delivered) position.

[0255] 将复位元件设置到操作状态的管筒保持件2的旋转运动(不存在轴向移动),其优势在于,在插入新管筒之后,第一次使用药物输送设备1之前,不会在管筒的活塞上积累任何压力。 [0255] The reset element is set to the operating state of the rotational movement of the cartridge holder 2 (there is no axial movement), its advantage lies in inserting a new tube after the first use of the drug delivery device prior to 1, will not Accumulation any pressure on the piston tube of.

Referenced by
Citing PatentFiling datePublication dateApplicantTitle
CN103649689A *12 Jul 201219 Mar 2014赛诺菲-安万特德国有限公司A drug delivery device
CN103649689B *12 Jul 201214 Dec 2016赛诺菲-安万特德国有限公司药物递送装置
CN103998080A *6 Dec 201220 Aug 2014尤尼特拉克特注射器公司Accurate dose control mechanisms and drug delivery syringes
CN103998080B *6 Dec 20128 Mar 2017尤尼特拉克特注射器控股有限公司精准剂量控制装置及药品传送注射器
CN104334214B *28 May 20135 Sep 2017赛诺菲-安万特德国有限公司用于药物输送装置的活塞杆和包括活塞杆的药物输送装置
CN105050640A *10 Mar 201411 Nov 2015赛诺菲-安万特德国有限公司Drive mechanism for a drug delivery device
US959745728 May 201321 Mar 2017Sanofi-Aventis Deutschland GmbhPiston rod for a drug delivery device and drug delivery device comprising a piston rod
Classifications
International ClassificationA61M5/315, A61M5/24
Cooperative ClassificationA61M5/24, A61M5/31511, A61M5/31593, A61M2202/04, A61M5/31533, A61M5/3155, A61M5/31576, A61M2207/00, A61M5/31583, A61M5/31543, A61M5/31535, A61M5/31541, A61M5/31575, A61M5/31585, A61M5/31558, A61M5/31551, A61M2005/2407, A61M2205/582, A61M2205/581, A61M2005/2488, A61M5/3146
European ClassificationA61M5/24, A61M5/315F2B1, A61M5/315E2B1A
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