CN101301508B - Chemical reaction air pressure type device for releasing intestines and stomach medicament using ultrasonic triggering control - Google Patents
Chemical reaction air pressure type device for releasing intestines and stomach medicament using ultrasonic triggering control Download PDFInfo
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- CN101301508B CN101301508B CN2008100290850A CN200810029085A CN101301508B CN 101301508 B CN101301508 B CN 101301508B CN 2008100290850 A CN2008100290850 A CN 2008100290850A CN 200810029085 A CN200810029085 A CN 200810029085A CN 101301508 B CN101301508 B CN 101301508B
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Abstract
The invention discloses an ultrasonic triggered and controlled chemical reaction air-operated intestine and stomach drug release device, consisting of a shell, a compressed air source unit, a drug storage sac, one-way valves and a drug storage chamber, wherein, the compressed air source unit is separated from the drug storage sac through an one-way valve; another one-way valve is arranged on a drug release opening positioned on the shell; the compressed air source unit is divided into two compartments through an animal fat layer; the two compartments are respectively filled with different chemical substances, wherein, the chemical substance of at least one compartment is solution and contacts the animal fat layer; the solution generates ultrasonic cavitation effect under the action of ultrasonic sound so as to disperse the animal fat layer and make the chemical substances in the two compartments generate contact reaction; gas generated by the reaction pushes away the one-way valve on one side of the drug storage sac, and the pressure in the drug storage chamber on the other side of the drug storage sac is increased when the drug storage sac is compressed by air pressure, thereby the other one-way valve is pushed away to realize drug release. The ultrasonic triggered and controlled chemical reaction air-operated intestine and stomach drug release device has a simple structure, is safe and high-efficiency, and does not need direct energy supply in the device.
Description
Technical field
The present invention relates to intestines and stomach drug release device field, be specifically related to utilize the chemical reaction gas pressure type intestines and stomach drug release device of ultrasonic triggering control.
Background technology
Sound wave is one of classification that belongs to sound, belongs to mechanical wave, and frequency is higher than 20KHz and then is called ultrasound wave.Ultrasound wave has following characteristic: 1) ultrasound wave can have effect spread in media such as gas, liquid, solid, solid solution; 2) ultrasound wave can transmit very strong energy; When 3) ultrasound wave is propagated, can on the interface, produce intensive impact and cavitation phenomenon in liquid medium." ultrasonic cavitation " typically refers to, the micro-bubble that exists in the liquid (cavitation nucleus) a series of dynamic processes such as the vibration that shown, growth, contraction, collapse that under the ultrasound wave effect, are activated, theoretical and experimental study confirms, cavitation processes can be got up sound field concentration of energy (focusing), follow cavitation bubble to collapse moment, energy with its high concentration in the little space in liquid discharges, form thundering high temperature (＞5000k), high pressure (＞5 * 10
7Pa), extreme physical condition such as jet.Thereby destroy insoluble dirt and they are scattered in the liquid.
Gastrointestinal tract class chronic disease is commonly encountered diseases and frequently-occurring disease, the person of having a strong impact on people's health and daily life.Gastrointestinal tract class chronic disease needs to treat by taking medicine mostly at present.Medicine is inner because the influence of gastric acid causes degraded at the human body intestines and stomach; diseased region may only absorb the medicine of minute quantity; it is slow that this Therapeutic Method exists curative effect; shortcomings such as treatment time is long; therefore, how to increase local therapeutic effects or increase specific part has become drug delivery problems research to the absorption of medicine key.MEMS (MEMS) is in the fast development of biology and medical domain, and drug disposition discharges Micro-Robot and obtained very big development at home and abroad.Drug release driving method, drug release device and control navigation system are the key technologies of drug release Micro-Robot.
The design and denomination of invention are that " chemical reaction gas pressure type microcapsule medicine release method and device thereof ", the patent No. are that the Chinese patent of ZL200510036638.1 has essential distinction, it has been done substantial improving and raising, overcome the deficiency of the interior MEMS of conventional bulk based on electromechanics or electromagnetic principle.
Summary of the invention
The objective of the invention is to overcome the prior art above shortcomings, a kind of chemical reaction gas pressure type intestines and stomach drug release device that utilizes ultrasonic triggering control is provided.The present invention is applied to the intestines and stomach drug release device with " the ultrasonic cavitation effect triggers control " and " chemical reaction gas pressure type promotion " the essence principle innovation, can realize non-contact control, for the intestines and stomach targeted therapy provides method, safe and efficient, simplify MEMS greatly and triggered the structure of controlling, dwindle physical dimension, reduce quality, improve the motility of operation, efficiently solve and trigger the energy supply problem, cheap, be convenient to application in the MEMS field.The present invention is achieved through the following technical solutions:
Utilize the chemical reaction gas pressure type intestines and stomach drug release device of ultrasonic triggering control, it is made of shell, compressed air source unit, medicament storage capsule, check valve and drug storage chamber, separate by check valve between described compressed air source unit and the medicament storage capsule, the drug release mouth place that is positioned on the shell is provided with another check valve; Described compressed air source unit is separated into two cabins by an animal oil layer, the different chemical material is equipped with in this two cabin respectively, wherein to have chemical substance in the cabin at least be solution and contact with described animal oil layer, this solution produces the ultrasonic cavitation effect and makes described animal oil layer be scattered in the solution and make the chemical substance in described two cabins come in contact reaction under ultrasonication, the gas that reaction generates is pushed the check valve of medicament storage capsule one side open, the medicament storage capsule makes the drug storage chamber internal pressure of its opposite side increase under the air pressure compression, and then pushes described another check valve open and realize drug release.
In the above-mentioned chemical reaction gas pressure type intestines and stomach drug release device that utilizes ultrasonic triggering control, also comprise permanent magnet, permanent magnet is seal-installed in the material of shell.
In the above-mentioned chemical reaction gas pressure type intestines and stomach drug release device that utilizes ultrasonic triggering control, described shell by one of housing, housing two, four the constituting of three and housing of housing, one of housing and four of housing lay respectively at the two ends of whole device, permanent magnet be sealed in one of housing and housing two between; Three of two and housing of housing is tightly connected, described compressed air source unit two and housing of housing three between, and be divided into two cabins by the terminal intubate that scribbles animal oil, two of the peripheral edge of intubate and housing closely cooperates, and has at least a cabin that solution is housed in two cabins; Three and housing of housing four between be tightly connected and leave a cavity, the part that is tightly connected is pressed and is connected the medicament storage capsule, one side of medicament storage capsule by housing three in the check valve and the compressed air source unit that are provided with separate, the opposite side of medicament storage capsule and described cavity form drug storage chamber, housing four in be provided with the drug release mouth that is communicated with described cavity, this drug release mouth is by described another check valve sealing.
In the above-mentioned chemical reaction gas pressure type intestines and stomach drug release device that utilizes ultrasonic triggering control, the axial cross section of described intubate is trapezoidal.
In the above-mentioned chemical reaction gas pressure type intestines and stomach drug release device that utilizes ultrasonic triggering control, in two cabins of described compressed air source unit, wherein acetic acid is equipped with in a cabin, and crystals of sodium carbonate is equipped with in another cabin, separates with the animal oil layer between two cabins.
In the above-mentioned chemical reaction gas pressure type intestines and stomach drug release device that utilizes ultrasonic triggering control, it is 36% acetic acid that mass concentration is equipped with in one cabin of described compressed air source unit, crystals of sodium carbonate and saturated solution of sodium carbonate are equipped with in another cabin, and crystals of sodium carbonate is close to the animal oil layer.
In the above-mentioned chemical reaction gas pressure type intestines and stomach drug release device that utilizes ultrasonic triggering control, described animal oil layer is solid-state or does not have the molten state of flowability.
In the above-mentioned chemical reaction gas pressure type intestines and stomach drug release device that utilizes ultrasonic triggering control, described check valve is filled sealing by natural gum and is formed; Medicine to be discharged is housed in the described drug storage chamber.
The present invention compared with prior art has following advantage:
1, simple in structure, safe and efficient.The present invention utilizes " chemical reaction gas pressure type " and " ultrasonic cavitation effect " principle, has greatly simplified capsule structure, and the inner space utilization rate improves, and cheap.Apparatus of the present invention inside need not little power supply, has used ultrasonic triggering control.No matter be ultrasound wave, animal oil (Adeps Sus domestica), still participate in the chemical drugs of reaction satisfying the human body safety requirements;
2, be quick on the draw handled easily.Near behind the local 10-15s of lesion locations, the Adeps Sus domestica in the MEMS drug release device is scattered in the acetic acid unlatching ultrasonic unit outside human body, and reaction begins the handled easily personnel operation automatically;
3, no energy requirement supply in device in the trigger process.Outside ultrasound wave was exactly a kind of energy portable object originally, need not the problem of considering that energy is under-supply, had solved the wired or wireless power transfer problem of puzzlement MEMS development.
Description of drawings
Fig. 1 is the structural representation of apparatus of the present invention.Among the figure, 1, one of housing; 2, permanent magnet; 3, two of housing; 4,36% acetic acid; 5, animal oil layer; 6, intubate; 7, crystals of sodium carbonate; 8, saturated solution of sodium carbonate; 9, check valve (natural gum); 10, three of housing; 11, medicament storage capsule; 12, drug storage chamber (medicine is housed); 13, four of housing; 14, check valve (natural gum).
The specific embodiment
Apparatus of the present invention are applicable to intestines and stomach targeted therapy MEMS, and this example is an example with MEMS in the body.Below in conjunction with accompanying drawing the specific embodiment of the present invention is described further.
As shown in Figure 1, in the present embodiment, utilize the chemical reaction gas pressure type intestines and stomach drug release device of ultrasonic triggering control to be the microcapsule formula, interconnect by shell, permanent magnet 2, intubate 6,36% acetic acid 4, crystals of sodium carbonate 7, saturated solution of sodium carbonate 8, Adeps Sus domestica layer 5, natural gum and medicament storage capsule 11 and form.Shell by one of housing 1, housing 23,4 13 the constituting of 3 10 and housing of housing, one of housing 1 and 4 13 of housing lay respectively at the two ends of whole device (microcapsule), permanent magnet 2 be sealed in one of housing 1 and housing 23 between; 3 10 of 23 and housing of housing is tightly connected, described compressed air source unit 23 and housing of housing 3 10 between, and be divided into two cabins by the terminal intubate 6 that scribbles Adeps Sus domestica layer 5,23 of the peripheral edge of intubate 6 and housing closely cooperates, and has at least a cabin that solution is housed in two cabins; 3 10 and housing of housing 4 13 between be tightly connected and leave a cavity, the part that is tightly connected is pressed and is connected medicament storage capsule 11, one side of medicament storage capsule 11 by housing 3 10 in the check valve that is provided with 9 separate with compressed air source unit, the opposite side of medicament storage capsule 11 and described cavity form drug storage chamber 12, housing 4 13 in be provided with the drug release mouth that is communicated with described cavity, this drug release mouth is by described another check valve 14 sealings, and in the present embodiment, check valve adopts natural gum to fill sealing and forms.
In this enforcement profit, crystals of sodium carbonate 7 and saturated solution of sodium carbonate 8 are loaded on right cabin, and crystals of sodium carbonate 7 keeps left, and is close to Adeps Sus domestica, to separate Adeps Sus domestica and saturated solution of sodium carbonate 8; 36% acetic acid 4 is loaded on 5 cabins, and 3 10 of housing is connected with 4 13 of housing, and the convergence part dividing potential drop connects medicament storage capsule 11, and medicament storage capsule 11 forms drug storage chambers with 4 13 of housing, waits to discharge the medicine filling wherein.The chemicals filler of compressed air source unit and the medicine filler of drug storage chamber are all sealed by natural gum.
Above-mentioned microcapsule is under human oral, utilize wireless magnetic control navigation system to monitor capsular operation conditions and operation position, when capsule arrives patient's diseased region, open supersonic generator, (ultrasonic power is 100W to produce ultrasound wave, supersonic frequency is 45KHz) pass through acetic acid, ultrasonic time 15s, under hyperacoustic " cavitation ", the Adeps Sus domestica that plays " obstruct " effect is scattered in the acetic acid rapidly, thereby makes acetic acid successively contact the generation chemical reaction with crystals of sodium carbonate with saturated solution of sodium carbonate, generate pressed gas, produce the motive force of drug release, push natural gum (i.e. check valve 9 among the figure) open, pressed gas enters the medicine apotheca, make drug storage chamber pressure increase rapidly, push natural gum (i.e. check valve 14 among the figure) open, medicine is extruded under the pressed gas effect, thereby realizes drug release.
In the present embodiment, this device discharges by chemical reaction gas pressure type method drives medication, adopts microcapsule formula drug release device and wireless magnetic control positioned internal system.The chemical reaction gas pressure type medicine release method is to send two kinds of harmless chemical substance generation chemical reactions of ultra-sonic remote control by the external supersonic wave apparatus to generate innocuous gas, by air pressure drives medication storage capsule, discharges by compression storage capsule drives medication.Wireless magnetic control positioning system using permanent magnet and three magnetoresistive transducers.
Selecting for use of present embodiment material: shell-POM, medicament storage capsule-PU.The mode that the present invention adopts ultrasound wave to trigger, simple in structure, be quick on the draw, safe and reliable, greatly simplified trigger mechanism, realized non-contact control, solved the energy supply problem that all the time perplexs the capsule exploitation; The chemical equation microcapsule structure is simple, and inner space utilization rate height makes the microcapsule medicine amount of carrying account for whole volumetrical 40～50%; Overall dimensions dwindles, and carries pharmacy variety and increases, and manufacturing cost reduces, and is convenient to drug disposition and discharges applying of Micro-Robot.
Claims (7)
1. utilize the chemical reaction gas pressure type intestines and stomach drug release device of ultrasonic triggering control, it is characterized in that constituting by shell, compressed air source unit, medicament storage capsule, check valve and drug storage chamber, separate by check valve (9) between described compressed air source unit and the medicament storage capsule, the drug release mouth place that is positioned on the shell is provided with another check valve (14); Described compressed air source unit is separated into two cabins by an animal oil layer (5), the different chemical material is equipped with in this two cabin respectively, wherein to have chemical substance in the cabin at least be solution and contact with described animal oil layer, this solution produces the ultrasonic cavitation effect under the ultrasound wave effect be scattered in the solution described animal oil layer (5), make the chemical substance in described two cabins come in contact reaction, the gas that reaction generates is pushed the check valve (9) of medicament storage capsule one side open, the medicament storage capsule makes the drug storage chamber internal pressure of its opposite side increase under the air pressure compression, and then push described another check valve (14) open and realize drug release, described animal oil layer is solid-state or does not have the molten state of flowability.
2. the chemical reaction gas pressure type intestines and stomach drug release device that utilizes ultrasonic triggering control according to claim 1 is characterized in that also comprising that permanent magnet, permanent magnet are seal-installed in the material of shell.
3. chemical reaction gas pressure type intestines and stomach drug release device according to claim 2, it is characterized in that described shell by one of housing, housing two, four the constituting of three and housing of housing, one of housing and four of housing lay respectively at the two ends of whole device, permanent magnet be sealed in one of housing and housing two between; Three of two and housing of housing is tightly connected, described compressed air source unit two and housing of housing three between, and be divided into two cabins by the terminal intubate that scribbles the animal oil layer, two of the peripheral edge of intubate and housing closely cooperates, and has at least a cabin that solution is housed in two cabins; Three and housing of housing four between be tightly connected and leave a cavity, the part that is tightly connected is pressed and is connected the medicament storage capsule, one side of medicament storage capsule by housing three in the check valve and the compressed air source unit that are provided with separate, the opposite side of medicament storage capsule and described cavity form drug storage chamber, housing four in be provided with the drug release mouth that is communicated with described cavity, this drug release mouth is by described another check valve sealing.
4. chemical reaction gas pressure type intestines and stomach drug release device according to claim 3, the axial cross section that it is characterized in that described intubate is trapezoidal.
5. according to each described chemical reaction gas pressure type intestines and stomach drug release device that utilizes ultrasonic triggering control of claim 1～4, it is characterized in that in two cabins of described compressed air source unit, wherein acetic acid is equipped with in a cabin, and crystals of sodium carbonate is equipped with in another cabin, separates with the animal oil layer between two cabins.
6. the chemical reaction gas pressure type intestines and stomach drug release device that utilizes ultrasonic triggering control according to claim 5, it is 36% acetic acid that mass concentration is equipped with in a cabin that it is characterized in that described compressed air source unit, crystals of sodium carbonate and saturated solution of sodium carbonate are equipped with in another cabin, and crystals of sodium carbonate is close to the animal oil layer.
7. chemical reaction gas pressure type intestines and stomach drug release device according to claim 5 is characterized in that described check valve is formed by natural gum filling sealing.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100290850A CN101301508B (en) | 2008-06-27 | 2008-06-27 | Chemical reaction air pressure type device for releasing intestines and stomach medicament using ultrasonic triggering control |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008100290850A CN101301508B (en) | 2008-06-27 | 2008-06-27 | Chemical reaction air pressure type device for releasing intestines and stomach medicament using ultrasonic triggering control |
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| CN101301508A CN101301508A (en) | 2008-11-12 |
| CN101301508B true CN101301508B (en) | 2010-06-02 |
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| CN2008100290850A Expired - Fee Related CN101301508B (en) | 2008-06-27 | 2008-06-27 | Chemical reaction air pressure type device for releasing intestines and stomach medicament using ultrasonic triggering control |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105920723A (en) * | 2016-05-19 | 2016-09-07 | 清华大学 | Electronic capsule capable of releasing accommodated substances quantitatively |
| CN117159147A (en) * | 2020-07-27 | 2023-12-05 | 彭志军 | Wire-control magnetic force ultrasonic cavitation motion body internal physiotherapy robot device |
| CN113769249B (en) * | 2021-09-10 | 2023-08-04 | 安翰科技(武汉)股份有限公司 | Drug delivery capsule |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4675174A (en) * | 1985-08-16 | 1987-06-23 | Alza Corporation | Veterinary dispenser delivering beneficial agent by gas power generated in situ |
| US5279607A (en) * | 1991-05-30 | 1994-01-18 | The State University Of New York | Telemetry capsule and process |
| CN1295866A (en) * | 1999-07-26 | 2001-05-23 | 朱利控股有限公司 | Apparatus and method for curing body tissue by electric current or medicine |
| CN1730118A (en) * | 2005-08-19 | 2006-02-08 | 华南理工大学 | Chemical reaction gas pressure type microcapsule medicine release method and apparatus thereof |
| CN101107038A (en) * | 2005-01-18 | 2008-01-16 | 皇家飞利浦电子股份有限公司 | Electronically controlled capsule |
| CN201029954Y (en) * | 2006-12-26 | 2008-03-05 | 重庆大学 | Medicine-releasing electric capsule |
| CN201211389Y (en) * | 2008-06-27 | 2009-03-25 | 华南理工大学 | Chemical reaction vapor pressure type intestines and stomach drug releasing device suitable for ultrasonic trigger control |
-
2008
- 2008-06-27 CN CN2008100290850A patent/CN101301508B/en not_active Expired - Fee Related
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4675174A (en) * | 1985-08-16 | 1987-06-23 | Alza Corporation | Veterinary dispenser delivering beneficial agent by gas power generated in situ |
| US5279607A (en) * | 1991-05-30 | 1994-01-18 | The State University Of New York | Telemetry capsule and process |
| CN1295866A (en) * | 1999-07-26 | 2001-05-23 | 朱利控股有限公司 | Apparatus and method for curing body tissue by electric current or medicine |
| CN101107038A (en) * | 2005-01-18 | 2008-01-16 | 皇家飞利浦电子股份有限公司 | Electronically controlled capsule |
| CN1730118A (en) * | 2005-08-19 | 2006-02-08 | 华南理工大学 | Chemical reaction gas pressure type microcapsule medicine release method and apparatus thereof |
| CN201029954Y (en) * | 2006-12-26 | 2008-03-05 | 重庆大学 | Medicine-releasing electric capsule |
| CN201211389Y (en) * | 2008-06-27 | 2009-03-25 | 华南理工大学 | Chemical reaction vapor pressure type intestines and stomach drug releasing device suitable for ultrasonic trigger control |
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