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Publication numberCN101102727 B
Publication typeGrant
Application numberCN 200580042791
PCT numberPCT/SE2005/001895
Publication date27 Mar 2013
Filing date12 Dec 2005
Priority date13 Dec 2004
Also published asCN101102727A, EP1827289A1, EP1827289A4, EP1827289B1, EP3135240A1, US8377106, US20080125868, WO2006065205A1
Publication number200580042791.3, CN 101102727 B, CN 101102727B, CN 200580042791, CN-B-101102727, CN101102727 B, CN101102727B, CN200580042791, CN200580042791.3, PCT/2005/1895, PCT/SE/2005/001895, PCT/SE/2005/01895, PCT/SE/5/001895, PCT/SE/5/01895, PCT/SE2005/001895, PCT/SE2005/01895, PCT/SE2005001895, PCT/SE200501895, PCT/SE5/001895, PCT/SE5/01895, PCT/SE5001895, PCT/SE501895
Inventors里卡德布雷恩马克, 彼得汤姆森
Applicant里卡德布雷恩马克咨询公司, 生物材料开发哥德堡公司
Export CitationBiBTeX, EndNote, RefMan
External Links: SIPO, Espacenet
An implant and an implant member
CN 101102727 B
Abstract  translated from Chinese
一种包含用于连接到人体或动物体的活的生物组织装置(1、12、9.12)的植入物,该植入物具有包含第一部分和第二部分的外表面,这两部分在每部分与生物组织的生物相容性方面具有不同的属性,其中该植入物包含至少一个表面部(2、15、20),该表面部包含构成所述第一部分的基础表面(3、16、21)和一个或若干构成所述第二部分的界定区域(4、5、6、7、17、22、23、24、25、26、27、28、29、30、31)。 Comprising an implant for connection to living biological tissue of the human or animal body means (1,12,9.12), which implant has an outer surface comprising a first portion and a second portion, the two parts in each biocompatibility with biological tissue portions having different properties, wherein the implant comprises at least one surface portion (2,15,20), the surface portion comprising a base surface constituting the first portion (3, 16, 21) and one or several defined regions constituting said second portion (4,5,6,7,17,22,23,24,25,26,27,28,29,30,31). 一种用于制造所述植入物的方法,其中将穿孔的掩蔽单元(9、5.9、6.9)施加到该植入物上,以及一种用于所述方法的掩蔽单元(9、5.9、6.9)。 A method for producing the implant, wherein the perforated masking unit (9,5.9,6.9) is applied to the implant, and a masking unit (9,5.9 A method for the, 6.9). 一种包含用于连接到人体或动物体的活的生物组织装置(40)的植入物部件,该植入物具有外表面,其中所述外表面包含至少一个表面区域(41),该表面区域的表面进行表形修改,以及一种用于制造该植入物部件的方法。 The implant member comprising a living biological tissue means for connection to the human or animal body (40), the implant having an outer surface, wherein said outer surface comprises at least one surface region (41), the surface surface area of a table-shaped modified, and a method of manufacturing the implant member is used.
Claims(5)  translated from Chinese
1. 一种植入物部件,包含用于连接到人体或动物体的活生物组织的装置,该植入物具有外表面,其特征在于所述外表面包含至少一个表面区域,对该表面区域的表面进行表形修改;将该表面区域定位在所述连接装置的区域中;该连接装置设有至少一个螺纹,并且将该表面区域定位在所述至少一个螺纹的根部中;通过提供若干凹陷使该表面区域形成图案,其中沿所述至少一个螺纹的根部的纵向延伸一个接一个地提供所述凹陷,使得通过所述凹陷,所述表面区域在所述连接装置的横截面中具有波纹形状;并且该表面区域具有介INM于O. 8和10 μ m之间的Sa的表面,其中通过下面等式\ =ΙϋΣΣ|ζ(χ/,Α)|计算Sa。 An implant member comprising means for connection to the living biological tissue of the human or animal body, the implant having an outer surface, wherein said outer surface comprises at least one surface region, the surface region the surface topography modification; surface area is located at the area of the connection device; the connecting means provided with at least one thread, and the surface area is located at the thread root of at least one; and by providing a number of recesses so that The surface area to form a pattern, wherein the at least one threaded root portion extending in the longitudinal direction one after providing said recesses, so that by the recess, the surface region having a corrugated shape in the cross section of the connecting means; and the surface region having a surface Sa dielectric INM between O. 8 and 10 μ m, wherein the following equation \ = ΙϋΣΣ | ζ (χ /, Α) | calculated Sa. JV y_l /-1 JV y_l / -1
2.根据权利要求1的植入物部件,其特征在于该表面区域延伸所述螺纹的至少一圈。 2. The implant member according to claim 1, characterized in that the surface region of the thread extends at least once.
3.根据权利要求1至2中任一项的植入物部件,其特征在于所述植入物部件的外表面由钛和/或钛合金构成。 The implant member 1 to any one of claims 2, wherein the outer surface of the implant member made of titanium and / or titanium alloy.
4.根据权利要求1的植入物部件,其特征在于Sa介于1. 2和5 μ m之间。 4. The implant member according to claim 1, characterized in that between 1.2 and 5 μ m Sa interposed.
5.根据权利要求1至4中任一项的植入物部件的制造方法,其特征在于借助于激光使所述表面区域形成图案。 5. The method for producing an implant component according to any one of claim 1 to 4, wherein said surface region by means of laser patterning.
Description  translated from Chinese

植入物和植入物部件 The implant and implant component

技术领域 FIELD

[0001] 本发明涉及一种植入物,其包含连接到人体或动物体的活的生物组织的装置,该植入物具有包含第一部分和第二部分的外表面,这两部分在每一部分与生物组织的生物相容性方面具有不同的属性,还涉及制造该植入物的方法,以及涉及所述方法中使用的掩蔽单元。 [0001] The present invention relates to an implant comprising living biological tissue connected to the means of the human or animal body, the implant having a first portion and a second portion comprising an outer surface, and two parts in each section biocompatibility of biological tissues have different properties, also relates to a method of manufacturing the implant, as well as to the masking unit used in the method. 此外,本发明涉及植入物部件,其包含连接到人体或动物体的活生物组织的装置,该植入物具有外表面,并涉及制造该植入物部件的方法。 Further, the present invention relates to an implant member, comprising means connected to the living biological tissue of the human or animal body, the implant having an outer surface, and to a method of manufacturing the implant member.

背景技术 BACKGROUND

[0002] 长期以来,在患者治疗中已经使用由各种材料制造的不同类型的植入物,作为去除骨组织的代替品用于骨折的固定,例如,在固定托牙或牙桥的牙科手术中,以及在其它应 [0002] For a long time, have been used in the treatment of patients with a variety of materials fixed by different types of implants, as a substitute for bone tissue removal fractures, for example, a fixed denture in dental surgery or dental bridge , and in other applications

用中。 By medium. 在二十世纪末,用不同类型的植入物材料,诸如金、陶瓷和银进行了试验。 In the twentieth century, with different types of implant materials, such as gold, ceramic and silver were tested. 在二十世纪30年代,建议使用维他良(Vitallium)金属合金,该金属合金是生物相容性材料,从那时开始在该金属合金上做了大量的研究,并且该金属合金在今天仍在使用。 In the 1930s, it is recommended to use Vita-liang (Vitallium) metal alloys, metal alloy which is a biocompatible material, and since then a lot of research began on the metal alloy, and the metal alloy still today in use. 在二十世纪50年代偶然发现钛有利的生物相容性,当时发现钛植入物能够与骨组织结合。 In the 1950s stumbled favorable biocompatibility of titanium, titanium implants was found to be able to bind to bone tissue. 这形成了骨性结合的概念基础。 This forms the basis for the concept of osseointegration. 从那时起,钛由于其良好的生物相容性,已经以纯的形式或以合金的形式被用于植入物。 Since then, the titanium because of its good biocompatibility, has in pure form or in the form of alloy is used for the implant. 随着时间的进展,钛和钛合金显示了出众的长期结果,尤其是发现钛是非致癌物的,这一结果得到了很好的证实。 As time progresses, titanium and titanium alloys show a superior long-term results, especially non-carcinogens found in titanium, this result has been well demonstrated. 然而,开始时,与能更好地与生物系统、例如周围组织反应的更具生物活性的材料对比,由于植入物中的钛和钛合金有关的仿生学属性,即不能与生物系统进行反应,所以植入物中钛和钛合金的使用仅限于高质量的骨组织。 However, at the beginning, and better with biological systems, such as contrast material more biological activity surrounding tissue reactions, due to the properties concerned bionic implants of titanium and titanium alloys, which can react with biological systems Therefore, the use of titanium and titanium implants are limited to high-quality bone tissue.

[0003] 为了增强植入物与周围组织的反应能力,大致需要两种处理来修改表面。 [0003] In order to enhance the reactivity of the implant with the surrounding tissue, takes roughly two processes to modify the surface. 其中一种处理是植入物的表形修改,例如使表面形成图案或浮雕/刻花来改进植入物与组织间的接触,另一种处理是植入物表面的化学修改,但也可能是这两种处理的组合。 One treatment is to modify the topography of the implant, e.g., the surface is patterned or relief / stencil to improve contact between the implant and the tissue, and the other processing is chemical modification of the implant surface, but may also is a combination of the two treatment.

[0004] 如今,对于表面的化学修改,存在若干已知合适的生物活性材料,其具有与生物系统进行反应的能力并且例如通过不同的沉积技术,诸如等离子体喷涂、脉冲激光沉积、溅射、爆喷等能将其应用到植入物的外表面上。 [0004] Now, the chemical modification of the surface, the presence of several known suitable bioactive material, which has the ability to react with biological systems and, for example by different deposition techniques, such as plasma spraying, pulsed laser deposition, sputtering, blast spray, etc. can apply it to the outer surface of the implant. 例如,这些生物活性材料的示例为磷酸钙,诸如羟磷灰石和磷酸三钙。 For example, Examples of such biologically active material is a calcium phosphate, such as hydroxyapatite and tricalcium phosphate.

[0005] 然而,存在与使用新材料和物质相关的缺点,因为它们的长期效果是未知的。 [0005] However, the existence and use of new materials and substances associated disadvantages because their long-term effects are unknown.

[0006] 存在调整植入物与生物组织反应的需求。 [0006] exist to adjust the implant and the biological tissue response needs. 制造两种不同材料的植入物先前是众所周知的,其中第一种材料覆盖植入物表面的一部分而第二种材料覆盖植入物表面的另一部分。 Manufacture of two different materials is previously known implants, in which a first portion of the implant material covering the surface of the second material covering the other part of the implant surface. 因此,在一定程度上有可能使植入物适合不同的需求。 Thus, to some extent, it is possible to make the implant for different needs. 然而,这一解决方式不够灵活并且不能提供充分适应的植入物。 However, this solution is not flexible enough and does not provide adequate adaptation implants.

[0007] 此外,存在调整植入物与生物组织反应的需求从而提供表面具有生物活性属性的植入物,使其因此可以与周围组织进行反应,同时具有很好验证的长期效果。 [0007] In addition, the presence of the biological tissue response to the implant adjustment and needs thus providing an implant having bioactive surface properties, so that it can react with the surrounding tissue, but also has good long-term results verified.

[0008] 因此本发明的目的是提供一种具有改进表面属性和良好生物相容性的植入物,尤其是一种具有生物活性属性的植入物,同时它还具有很好验证的长期效果。 [0008] Thus an object of the invention is to provide an improved surface properties and good biocompatibility of the implant, in particular an implant having bioactive properties, while it also has good long-term results verified . 此外,本发明的目的是提供制造这种植入物的方法。 Furthermore, object of the present invention to provide a method of manufacturing such implant. 发明内容 SUMMARY

[0009] 通过提供在权利要求1的前序部分中限定的植入物,并通过提供分别在权利要求17和19的前序部分中限定的方法和掩蔽单元来实现上述目的,其中该植入物包含至少一个表面部,该表面部包含构成所述第一部分的基础表面和构成所述第二部分的一个或若干界定区域,所述一个或若干界定区域由大量的界定面积组成,其数量超过五个;该方法和该掩蔽单元分别包含在权利要求17或18和19的特征部分中所提到的特定尺寸和特征。 [0009] By providing the preamble of claim 1 is defined in the implant, respectively, and by providing the preamble of claim 17 and 19 defining a method and masking means to achieve the above object, wherein the implant comprises at least one surface portion, the surface portion comprising a base surface constituting said first portion and a second portion constituting or several of the defined area, said one or several delimited area defined by a large number of the area, whose quantity exceeds five; The method and the masking unit respectively include specific dimensions and features in the characterizing part 17 or 18 and 19 in the claims mentioned.

[0010] 通过提供包含基础表面和一个或若干预先分布的界定区域的表面部,其中基础表面就其与生物组织生物相容性的属性不同于所述一个或若干界定区域的属性,提供表面的多相组织使其提供调整植入物与不同特定生物系统反应的可能性,这不可能用表面的同相组织来实现,其中该植入物的外表面包含就生物相容性相同属性的大片面积,例如相同材料的大片面积。 [0010] By providing a surface portion comprising a base surface and one or several pre-defined area of the distribution, wherein the base surface on which biological tissue biocompatibility properties different from the properties of one or several defined regions, to provide surface multi-phase structure so that it provides the possibility of adjusting the implant and the different reactions of particular biological systems, which can not use the same phase to realize the tissue surface, wherein the outer surface of the implant material comprising biocompatible same properties on a large area , e.g., a large area of the same material. 可在植入物上的特定位置提供所述的表面部,其中在移植之后与生物系统的特定部位具有某种反应是可取的。 Implant material in a particular location on said surface portion is provided, which after migration to specific sites in biological systems with a certain reaction is desirable. 基础表面可以具有与植入物剩余外表面相同的材料,即外表面在所述表面部之外,或者界定区域可以具有与植入物剩余外表面相同的材料。 Base surface may have a remaining outer surface of the implant of the same material, i.e., the outer surface outside the portion of the surface, or to define the remaining region may have the same outer surface of the implant material. [0011] 根据本发明植入物的有利实施例,不同的属性在关于所述生物组织的范围效果方面和/或关于每部分与生物组织反应的时间方面是不同的。 [0011] According to an advantageous embodiment of the invention the implant, in a range of different properties with respect to the effect of the biological tissue and / or on the timing of each part with biological tissue response is different.

[0012] 所述界定面积的数量可有利地超过20个,并且在一些情况下超过50个。 [0012] define the number of areas may advantageously more than 20, and in some cases more than 50. 所述界定面积可分别具有0.1到0. 3mm2的大小,并对最邻近的其它界定面积具有至少I到3_的距离,有利地至少为2_。 The defined area may each have a size of 0.1 to 0. 3mm2, and the nearest other defined area having at least a distance of I to 3_, advantageously at least 2_. 通过这一面积分布,使在和生物组织生物相容性方面的第一属性被具有在和生物组织生物相容性方面的其它属性的基础表面包围,在特定区域内植入物可给出特定的生物相容性,这便于所述植入物在组织中的结合。 Through this area distribution, and so that in a first biological tissue biocompatibility and biocompatible properties are in terms of having a biological tissue surrounded by the base surface other properties, was implanted in a specific area can be given a specific biocompatibility, which facilitates conjugate the implant in the tissue.

[0013] 根据本发明植入物的又一有利实施例,所述一个或若干界定区域形成基本上是圆形、椭圆形和/或条状或所述形状的过渡形状的界定面积。 [0013] Advantageously the present invention according to yet another embodiment of an implant, said one or several delimited area defining area is formed substantially circular, oval and / or strip or a shape of the transition.

[0014] 根据本发明植入物的又一有利实施例,所述一个或若干界定区域由施加到基础表面上的沉积物(deposit)或涂层组成,该沉积物可具有0.05到5iim的厚度,优选0.1到3um0有利的,这些沉积物具有不均匀的厚度,并且它们朝着它们的边缘区域变薄。 According to a further advantageous embodiment of the implant of the present invention, the one [0014] or by the application of a number of defined areas to deposit (deposit) on the base surface or coating composition, the deposit may have a thickness of 0.05 to 5iim , preferably from 0.1 to 3um0 Advantageously, these deposits have a non-uniform thickness, and their thinner towards their edge regions. 沉积物的不均匀厚度和不平坦表面促进了植入物和组织之间的接触。 Uneven thickness and uneven surface sediments to promote contact between the implant and the tissue.

[0015] 根据本发明植入物的有利实施例,基础表面覆盖植入物表面部的50到98%,在一些情况下为它的70到95%,而在其它情况下甚至为它的85到95%。 [0015] According to an advantageous embodiment of the invention the implant, the base surface covering 50 to 98% portion of the implant surface, in some cases it is 70-95%, and even for its 85 in other cases to 95%.

[0016] 根据本发明植入物的另外的有利实施例,植入物的外表面包含至少两种不同的材料,所述基础表面包含第一材料,并且所述一个或若干界定区域包含至少一个第二材料。 [0016] According to a further advantageous embodiment of the implant of the present invention, the outer surface of the implant comprises at least two different materials, the base surface comprises a first material, and said one or several delimited area comprising at least one the second material. 这一实施例能够,尤其能够产生具有生物活性属性的生物相容性植入物,其同时具有很好验证的长期效果,所述第一材料例如是钛、氧化钛和/或钛合金,它们是公知的并具有很好验证的长期效果,而所述至少一个第二材料包含一种或若干生物活性材料,其以生物活性的方式与周围生物组织进行反应,反之亦然。 This embodiment can, in particular, to produce biocompatible implant having bioactive properties, which also has good long-term results verified, the first material, for example, titanium, titanium oxide and / or titanium alloys, which is well known and has good long-term results verified, and said at least one second material comprises one or several biologically active material in a biologically active manner to react with the surrounding biological tissue, and vice versa.

[0017] 可用来代替钛的其它材料的示例,例如是元素铌、铪、锆、钽和各种合金或所述元素的氧化物,以及诸如不锈钢、钴铬等其它合金。 [0017] Examples of other materials can be used in place of titanium, and other alloying elements such as niobium, hafnium oxide, zirconium, tantalum, and various alloys or the element, as well as stainless steel, cobalt chromium.

[0018] 生物活性材料的示例是周期表中化学族的盐,其包含钙,例如包含磷酸钙的物质,或更精确地包含羟磷灰石、聚合物、高分子、氨基酸、缩氨酸、蛋白质、药物、细胞和其它晶状体和/或无定形态的生物活性陶瓷的材料。 Examples of bioactive materials [0018] Periodic Table of chemical groups salts comprising calcium, e.g., calcium phosphate containing material, or more precisely comprises hydroxyapatite, polymers, polymers, amino acids, peptides, protein, drug, cells and other lens and / or amorphous form of bioactive ceramic materials. 这些可再吸收或不可再吸收。 These resorbable or non-resorbable. 已经发现羟磷灰石对牙科植入物特别有利。 Hydroxyapatite has been found particularly advantageous for dental implants.

[0019] 根据本发明植入物的有利实施例,第一材料和至少一个第二材料两者都由包含一种或若干上述生物活性材料的材料组成。 [0019] According to an advantageous embodiment of the invention the implant, both the first material and at least one second material by including one or several of the above-described biologically active material material.

[0020] 根据本发明植入物的另外的有利实施例,所述至少一个表面部的表面是例如通过形成图案或浮雕/刻花进行表形修改的。 [0020] According to a further advantageous embodiment of the invention the implant, the surface of the at least one surface portion, for example, by forming a pattern or relief / stencil performed phenotypic changes. 例如通过加工、微制、喷制、低温喷制、蚀刻、抛光、磨蚀或通过各种激光技术来有利地实现表面的表形修改。 For example by machining, micro system, spray system, low temperature spray system, etching, polishing, abrasion, or advantageously be achieved by modifying the surface topography of various laser techniques.

[0021] 根据本发明植入物的又一有利实施例,连接装置设有至少一种螺纹,但是其它连接装置也是可以的。 [0021] According to a further advantageous embodiment of the invention the implant, provided with at least one threaded connecting means, although other attachment means are possible. 对螺纹的可选方案例如是提供具有粗糙表面的连接装置,其借助于压力,例如,用纵向凹槽等连接到骨组织。 Of alternative thread e.g. a roughened surface is provided with connection means, which by means of pressure, for example, with a longitudinal groove connected to the bone and other tissue.

[0022] 此外,通过提供在权利要求21前序部分中限定类型的植入物部件可实现上述目的,其中所述外表面包含至少一个表面区域,通过例如形成图案或浮雕/刻花,以及通过在权利要求32的前序部分中限定的方法对该表面区域的表面进行表形修改,所述方法包含借助于激光使所述表面区域形成图案的特定措施。 [0022] Further, by providing the type defined in the introductory part of the implant member of the above object can be achieved prior to claim 21, wherein said outer surface comprises at least one surface area, for example, by forming a pattern or embossed / engraving, and by In the preamble of claim 32. A method as defined in the surface region of the surface shape modifying a table, the method comprising the surface region by means of laser light to form a pattern of specific measures.

[0023] 根据本发明植入物部件,通过提供若干凹陷来使该表面区域形成图案,并且将该表面区域定位在连接装置的区域内,连接装置设有至少一个螺纹,并将表面区域定位在所述至少一个螺纹的根部/谷底,并且沿根部纵向延伸一个接一个地设置所述凹陷。 [0023] According to the present invention, the implant member, by providing a plurality of recesses in the surface region is formed to make a pattern, and the surface area of the connecting means is positioned within a region, provided with at least one threaded connecting means, and positioned in the surface region said at least one thread root / bottom, and longitudinally extending root disposed one after the recess.

[0024] 根据本发明植入物部件其它有利实施例,穿过所述凹陷,表面区域在连接装置的横截平面上具有波纹形状,并且该表面区域延伸至少一圈螺纹,或至少一个螺距。 [0024] According to an implant member Further advantageous embodiments of the present invention, through the recessed surface region having a corrugated shape in the transverse plane of the connecting means, and the surface area of the thread extends at least once, or at least one pitch.

[0025] 根据本发明植入物部件的有利实施例,该表面区域具有在0. 8到IOiim之间的Sa的表面,Sa优选在1. 2到5 ym之间,其中Sa通过下面等式计算: [0025] According to an advantageous embodiment of the implant member of the present invention, the surface region having at 0.8 to IOiim between the surface Sa, Sa is preferably 1. Between 2 到 5 ym, wherein Sa by the following equation calculated as follows:

[0026] [0026]

Figure CN101102727BD00051

[0027] Sa是用于说明在植入物技术领域中表面粗糙度的公认参数。 [0027] Sa for describing the technical field of implants was recognized in the surface roughness parameters. 公式中参数Sa和变量的完整定义公开于,尤其是Ann Wennerberg的论文“OnSurface Roughness and ImplantIncorporation,,,Dept, of Biomaterial s/Handi cap Research, Institute for SurgicalSciences and Dept, of Prosthetic Dentistry, Goteborg University, Sweden,1996,ISBN91-628-1940-2 中。 Formula complete definition parameters Sa and variables are disclosed in, especially Ann Wennerberg paper "OnSurface Roughness and ImplantIncorporation ,,, Dept, of Biomaterial s / Handi cap Research, Institute for SurgicalSciences and Dept, of Prosthetic Dentistry, Goteborg University, Sweden , 1996, ISBN91-628-1940-2 in.

[0028] RickardBrdnemark 的论文“A Biomechanical Study ofOsseointegrationIn-vivo Measurements in Rat, Rabbit, Dog and Man”,G6teborg, Sweden, 1996,ISBN91-628-2267-5,公开了一种具有低Sa的加工表面,其具有较差的弹性变形属性和替代的充分塑性变形属性,这在生物力学上解释为表面在微观水平上太光滑以至与骨衔接远未到界面的含意。 [0028] RickardBrdnemark paper "A Biomechanical Study ofOsseointegrationIn-vivo Measurements in Rat, Rabbit, Dog and Man", G6teborg, Sweden, 1996, ISBN91-628-2267-5, discloses a machined surface with a low Sa, which have poor elastic deformation properties and sufficient alternative to plastic deformation properties, which is interpreted as the surface at the microscopic level is too smooth and even bone convergence implications far into the interface on the biomechanics. 此外,在牙科植入物上的研究显示表面“大”或“粗糙”的结构,例如包含具有直径200-400 um的孔或具有直径100-5000 um的球形烧结都成问题。 Further, on the dental implant studies show surface "large" or "rough" structure, e.g., comprising holes having a diameter of 200-400 um or with a spherical diameter of 100-5000 um sintering is a problem.

[0029] 在申请人的研究中,已经发现根据本发明植入物部件所述实施例的表面区域Sa的特定间隔对植入物部件与生物组织的反应非常有利,并且已发现提供最佳的生物力学。 [0029] In the studies of the applicant, it has been found that an implant component according to the embodiment of the present invention, the particular embodiment of the spacer surface area Sa of the reaction of biological tissue implant component is very beneficial, and have been found to provide the best Biomechanics. 此夕卜,如果将具有根据上述间隔Sa表面的表面区域与所述凹陷组合,这在连接装置的横截平面中给予表面区域波形形状,它可能深深地触及组织使得穿过组织与植入物之间界面的无定形区,同时,并没有出现在“粗糙”表面存在下出现的问题。 Bu this evening, if the interval Sa having the above surface of the recessed surface region in combination with, the surface area which gives the wavy shape in the cross-sectional plane of the connecting means, it may touch the tissue so deeply implanted through the tissue and the interface between the amorphous region thereof, at the same time, did not appear in the "rough" surface in the presence of problems. [0030] 根据本发明植入物部件另一有利实施例,植入物部件的外表面由钛和/或钛合金构成。 [0030] According to another advantageous embodiment of the implant member embodiment of the present invention, the outer surface of the implant member made of titanium and / or titanium alloy.

[0031] 根据本发明植入物部件又一有利实施例,该植入物部件包含植入物的特定特征,该特征在权利要求1至16中任一项中提及。 [0031] According to a further advantageous embodiment of the implant member of the present invention embodiment, the implant member comprises a particular feature of the implant, characterized in that any one of 1 to 16 mentioned in the claims.

[0032] 根据本发明植入物的有利实施例,该植入物包含植入物部件的特定特征,这些特征在权利要求21至28中任一项中提及。 [0032] According to an advantageous embodiment of the invention the implant, the implant comprising an implant member of a particular feature, these features in any one of claims 21 to 28 mentioned in the claims.

[0033] 通过将根据权利要求1至16中任一项的植入物的特定特征与根据权利要求21至28中任一项的植入物部件的特定特征相结合,提供处于外表面形式的协同效果,这对关于植入物或植入物部件与生物组织间的生物相容性非常有利,并且即使在存在螺纹、法兰等的情况下增强反应,这通过组织中的深层衔接导致了力学/生物力学的稳定性。 [0033] The particular feature according to claim implant 1 to 16 and according to any one of claims 21 to 28 characterized in specific implant member according to any one of the combination, provided in the form of the outer surface synergistic effect, which is biocompatible implant between on or the implant components and biological tissue is very favorable, and even in the case of the presence of enhanced reactive thread, flange, etc., this is done by the organization led to a deep link Mechanical stability / biomechanics. 附图说明 Brief Description

[0034] 为了例证的目的,现在借助于实施例并参考附带的附图将更详细地描述本发明,其中: Will be described in the drawings [0034] For illustrative purposes, by way of example and with reference now shipped in detail the present invention, wherein:

[0035] 图1是根据本发明植入物实施例的侧视图,具有若干沉积物形式的界定面积, [0035] FIG. 1 is a side view of the area defined in accordance with the present invention the implant, having a plurality of deposits in the form of,

[0036] 图2是通过根据本发明方法的实施例应用第一沉积物的表形图的示意性侧视图, [0036] FIG. 2 is a schematic side view of the first through the application of sediment table chart according to an embodiment of the inventive method,

[0037] 图3是通过根据本发明方法的实施例应用第二沉积物的表形图的示意性侧视图, [0037] FIG. 3 is formed by application of the present invention according to an embodiment of the second method of FIG deposits phenotypic schematic side view,

[0038] 图4是根据本发明掩蔽单元实施例的侧视图, [0038] FIG. 4 is a side view of the masking unit according to the present invention,

[0039] 图5是植入物实施例的侧视图,其中利用图4的掩蔽单元,通过根据本发明的方法实施例拟用条带状沉积物涂覆指示的界定面积, [0039] FIG. 5 is a side view of the implant of Example, wherein FIG masking unit 4, is proposed to define the area of the strip by example embodiment of the method according to the invention the coated strip sediment indicated,

[0040] 图6是图5所指示的界定面积的放大, [0040] FIG. 6 is an enlarged view 5 defined area indicated,

[0041] 图7是图解根据本发明方法实施例的示意性流程图, [0041] FIG. 7 is a schematic flow diagram illustrating a method according to the present invention,

[0042] 图8是根据本发明植入物有利实施例的示意性侧视图, [0042] Figure 8 is a schematic side view of advantageous embodiments of the implant according to the invention,

[0043] 图9是根据本发明植入物第二有利实施例的示意性侧视图, [0043] Figure 9 is a schematic side view of the implant material according to the second advantageous embodiment of the present invention,

[0044] 图10是根据本发明植入物部件实施例的一部分的示意图, [0044] FIG. 10 is a schematic view of a portion of the components of an embodiment of the implant material according to the present invention,

[0045] 图11显示沿图10的线AA的截面, [0045] Figure 11 shows a sectional view along the line AA 10,

[0046] 图12是显示图10的实施例和生物组织之间反应的柱形图;和 [0046] Figure 12 is a bar graph the reaction between the embodiment shown in Figure 10 and the biological tissue; and

[0047] 图13是根据本发明植入物部件实施例的侧视图。 [0047] FIG. 13 is a side view of the implant material components of an embodiment according to the present invention.

具体实施方式 DETAILED DESCRIPTION

[0048] 图1显示包含装置I用于永久或暂时连接到人体或动物体活的生物组织的牙科植入物,该组织可以坚硬或柔软的。 [0048] Figure 1 shows comprising means I for permanently or temporarily connected to the human or animal body tissue of a living organism dental implants, the tissue may be hard or soft. 在这该情况下连接装置I包含螺纹固定部分。 In this case the connecting means comprises a threaded fixing part I. 该植入物具有两种不同材料的外表面,其中第一种材料形成表面的第一部分,而至少一个第二种材料形成表面的第二部分。 The implant has an outer surface of two different materials, wherein the first material forming the first part of the surface, and at least one second material forming the second portion of the surface. 第一种材料是钛,但其它生物相容性材料也是可以的,而第二种材料是包含羟磷灰石的材料,该羟磷灰石有生物相容性和生物活性,但其它生物活性和/或生物相容性材料也是可以的。 The first material is titanium, but other biocompatible materials are possible, and the second material is a material comprising hydroxyapatite, the hydroxyapatite has biocompatibility and bioactivity, but other biologically active and / or biocompatible materials are possible. 钛和羟磷灰石在每种材料与生物组织的生物相容性方面具有不同的属性,该不同的属性在关于所述生物组织的范围效果(range effect)方面是不同的。 Titanium and hydroxyapatite have different properties in terms of each of the materials biocompatibility and biological tissue, which results in a range of different properties with respect to the biological tissue (range effect) terms are different. 该外表面包含表面部2,其由钛的基础表面3和若干界定面积(delimitedarea)构成,该基础表面3覆盖所述表面部2的70到90%,而若干界定面积由若干沉积物4、5、6、7构成,这些沉积物由包含羟磷灰石的材料组成,该若干沉积物已经施加到连接装置I的螺纹的根部8,这已经发现是有利的。 The outer surface comprises a surface portion 2, which is composed of titanium base surface 3 and defining a number of area (delimitedarea), the base surface 3 covering the surface portion 2 of from 70 to 90%, while the number of the area defined by a plurality of deposits 4, 5,6,7 constitution, these deposits of a material comprising hydroxyapatite composition, the number of deposits has been applied to the roots of the thread of the connecting means 8 I, which has been found to be advantageous. 沉积物4、5、6、7具有0.1到3iim的厚度,具有不均匀的厚度并朝着它们的边缘区域变得薄,这在图2和3中有所显示,图2和3分别显示通过根据本发明的方法实施例施加的第一和第二沉积物的表形图。 4,5,6,7 sediment having a thickness of 0.1 to 3iim having non-uniform thickness and toward the edge region thereof becomes thinner, which has been shown in Figures 2 and 3, Figures 2 and 3 show by The first and second embodiment is applied to a table sediment chart according to the method embodiment of the invention. 这导致了表面的Sa低于IOii m。 This leads to the surface Sa is below IOii m. 沉积物4、 Sediment 4,

5、6、7覆盖大致为圆形、椭圆和/或条带状或者所述形状的过渡形状的界定面积。 5,6,7 substantially covering strip or the shape of the transition area defining the shape of circular, oval and / or strip. 沉积物4、5、6、7可沉积在特定区域中或以特定的图案沉积以实现所需的生物效果。 4,5,6,7 sediments can be deposited in a specific area or in a particular pattern is deposited to achieve the desired biological effect. 牙科植入物基部的直径为大约4. 1_,而牙科植入物顶部的直径为大约3. 75_。 Dental implant base diameter of about 4. 1_, and the dental implant top thereof having a diameter of about 3. 75_. 该螺纹的尺寸满足:在螺纹的两个牙顶之间存在大约0. 6mm的距离。 Satisfying the thread size: about 0. 6mm distance exists between the two crests of the threads.

[0049] 图4显示根据本发明的掩蔽(masking)单元的实施例,根据本发明其可用在制造植入物的方法中(见图7)。 [0049] Figure 4 shows according to the present invention, masking (masking) Example units, according to the present invention which may be used in the method of manufacturing of the implant (see Fig. 7). 当施加沉积物,或以其它方式,例如通过喷砂在螺旋状的植入物上提供表面结构时,使用中空的圆柱状掩蔽单元9,其内周适于植入物的外周。 When the deposit is applied, or otherwise, for example by sandblasting the surface structure provided on a spiral implant, using a hollow cylindrical masking unit 9, which is adapted to the inner periphery of the outer periphery of the implant. 特别的,在植入物的外周和掩蔽单元9的内周之间应该有足够的距离,使得当在处理后去除掩蔽单元9时,所施加的沉积物不会被刮去。 In particular, between the implant and the inner periphery of the outer periphery of the masking unit 9 should have a sufficient distance such that when the mask is removed after the processing unit 9, the deposit will not be applied scrape. 掩蔽单元9包含若干纵向孔10,在根据本发明的方法中,材料能够穿过该孔并到达植入物。 Masking unit 9 comprises a plurality of longitudinal holes 10, in the method according to the present invention, material can reach through the hole and the implant. 掩蔽单元9由钛构成,但也可由钛合金或另一合适的材料构成。 Masking unit 9 is made of titanium, but may be a titanium alloy or another suitable material.

[0050] 在图5中显示图4掩蔽单元的切除掩蔽单元5. 9,这样显示被掩蔽单元5. 9包围并具有指示的界定面积11的植入物,当将植入物插入到掩蔽单元5. 9中时,图4中所示孔10定位在界定面积11的上方。 [0050] shown in Figure 4. The removal of the masking means masking unit 5.9 in Figure 5, so that the display unit 5.9 is masked area surrounding and defining indicative implant 11, when the implant is inserted into the masking unit 5.9 When, as shown in Figure 4, the hole 10 is positioned above the defined area 11.

[0051] 图6显示所述指示的界定面积6. 11的放大。 [0051] Figure 6 shows the defined area indicated by the enlarged 6.11.

[0052] 图7显示图解根据本发明方法实施例的示意性流程图,在该方法中使用根据本发明的掩蔽单元。 [0052] Figure 7 shows a method according to the present invention illustrating a schematic flowchart of one embodiment, the use of a masking means according to the present invention is in the method. 最初,在7.1中,在植入物上装配穿孔的掩蔽单元。 Initially, at 7.1, on the implant assembly perforated masking unit. 将设有掩蔽单元的植入物插入到溅射室中,在该溅射室中设有包含羟磷灰石材料的靶,并且在7. 2中,用合适的基本压力对该室加压。 The implant provided with the masking unit is inserted into the sputtering chamber, the target comprising hydroxyapatite material provided in the sputtering chamber, and 7.2, and with a suitable base pressure of the pressurizing chamber . 在7. 3中,溅射气体,在该情况下为氩与活性气体的混合物一起引入到该室中直到达到合适的工作压力。 In 7.3, the sputtering gas, in this case a mixture of argon and reactive gas is introduced into the chamber together until a suitable working pressure. 在7. 4中,在大约100瓦和大约13. 56MHz频率下运行射频发生器,这样在靶和设有掩蔽单元的植入物之间施加具有高频率的高电压,从而电离内部气体,离子从靶上敲下粒子。 In 7.4, a radio frequency generator running at approximately 100 watts and a frequency of about 13. 56MHz, so that the masking means is provided between the target and the implant is applied with a high frequency high voltage to the internal gas ionization, ion Qiaoxia particles from the target. 在7. 5中,这些粒子以某一角度穿过掩蔽单元的孔,该孔限定拟涂覆的面积,并且粒子沉积到植入物的所述面积中,该面积对应孔的形状。 In 7.5, these particles at an angle through the mask aperture unit, the aperture defining an area of quasi-coated, and the particles are deposited onto the area of the implant, the shape of the area corresponding to the hole. 这一溅射过程持续一小时,从而提供大约0.1 ym的沉积物。 The sputtering process lasts one hour, so as to provide about 0.1 ym deposits. 此后,在7. 6中,旋转设有掩蔽单元的植入物以便以第二角度溅射该植入物,从而实现包含羟磷灰石或任何其它合适材料的所需材料沉积物,于是在7. 5中来自所述靶的新粒子穿过掩蔽单元的孔并沉积在植入物的所述面积中。 Thereafter, in 7.6, the rotation unit is provided in order to implant masking sputtering at a second angle of the implant, in order to achieve the desired deposit material comprising hydroxyapatite, or any other suitable material, so in 7.5 New particles from the target cell through the mask aperture and deposited on the area of the implant. 在7. 7中,在以需要数量的其它角度执行溅射之后,完成植入物的涂覆。 In 7.7, after the required number of other angles to perform sputtering, the coating of the implant.

[0053] 此外,在如下方法中可使用类似的掩蔽单元,该方法中首先将钛植入物用包含羟磷灰石的材料涂层,其后将其插入到穿孔的掩蔽单元中,于是包含羟磷灰石的材料从掩蔽单元的孔面积上去除。 [0053] In addition, the following methods may be used in a similar masking element, the method is first a titanium implant with a coating material comprising hydroxyapatite, and thereafter inserted into a perforated masking unit, thus comprises hydroxyapatite material removed from the hole area masking means.

[0054] 掩蔽单元的孔图案适于在植入物表面部形成沉积物的图案。 Hole pattern [0054] The masking unit is adapted to the surface portion of the implant pattern deposits formed. 当然,存在用于制造根据本发明植入物上的所述表面部的若干其它可能的方法,例如蚀刻。 Of course, exists for manufacturing a number of other possible methods of the surface portion of the implant of the present invention on, for example, etching.

[0055] 图8显示包含装置12的第二牙科植入物,装置12呈现螺纹固定部分的形式,用于永久或暂时连接到人体或动物体的活的生物组织。 [0055] Figure 8 shows a dental implant comprising a second device 12, the fixed portion 12 presents a threaded form means for permanently or temporarily connected to the living biological tissue of the human or animal body. 该组织可以是坚硬或柔软的。 The organization may be hard or soft. 此外,该植入物具有基部13和可选设计的顶部14。 In addition, the implant having a base 13 and top 14 of alternative designs. 该植入物具有包含两种不同材料的外表面。 The implant has an outer surface comprising two different materials. 该外表面包含由钛的基础表面16和若干界定面积组成的表面部15,其中基础表面16覆盖所述表面部15的50到80%,若干界定面积由包含羟磷灰石的材料构成的沉积物17所组成,而沉积物17已施加到连接装置12螺纹的根部18。 The outer surface comprises a surface portion 16 and a plurality of base surfaces defining area 15 consisting of titanium, wherein the base surface 16 covers 50-80% of the surface portion 15, the deposition area is defined by a number of material comprising hydroxyapatite formed 17 composed of matter, while 17 have been applied to the root of the sediment 18 connecting means 12 threads. 沉积物17具有螺旋形状,其连续在螺纹的根部18中盘绕,并且该沉积物17具有0.1到3 ym的厚度。 Deposit 17 has a spiral shape, in which a continuous thread root 18 in a coiled, and the deposit 17 having a thickness of 0.1 到 3 ym of. 然而,该植入物具有邻接基部13的底部19,底部19的两圈螺纹不包括所述沉积物17。 However, this implant has a base 19 adjacent to the base portion 13, two turns of the thread 19 does not include the bottom 17 of the sediment.

[0056]图9显示第三牙科植入物,其以基本与图8的牙科植入物相同的方式设计,并具有带表面部20的外表面,该表面部20由钛的基础表面21和若干界定面积构成,其中该基础表面21覆盖所述表面部20的55到85%,若干界定面积为包括若干沉积物22、23、24、25、26、27、28、29、30、31的不连续螺旋形状,该若干沉积物由包含羟磷灰石材料构成,该若干沉积物已施加到连接装置9. 12螺纹的根部9. 18。 [0056] Figure 9 shows a third dental implant to the dental implant of FIG substantially the same manner as 8 design, and has an outer surface with a surface portion 20, 20 from the surface of the titanium base portion 21 and the surface Several defined area constituted, wherein the base surface 21 of the surface portion 20 of the cover 55 to 85 percent, a number of defined area includes a plurality of sediment 22,23,24,25,26,27,28,29,30,31 discontinuous spiral shape, the number of deposits by comprising hydroxyapatite material, which has been applied to a number of connecting means deposits 9.12 thread root 9.18. 沉积物22、23、24、25、26、27、28、29、30、31彼此由间隔隔开(该间隔包含基础表面21),并沿螺纹的根部9. 18延伸,使得沉积物22、23、24、25、26、27、28、29、30、31之间的间隔围绕牙科植入物的中心轴线不规则地定位。 Spaced apart from each other sediments 22,23,24,25,26,27,28,29,30,31 (the spacer comprises a base surface 21), and extending along the root 9.18 of the thread, so that the deposits 22, intervals around the center axis of the dental implant positioned 23,24,25,26,27,28,29,30,31 irregularly between. 同样可将沉积物22、23、24、25、26、27、28、29、30、31有利地分布成使得它们以这样的方式沿螺纹的根部9. 18延伸,从而沉积物22、23、24、25、26、27、28、29、30、31之间的间隔围绕牙科植入物的中心轴线规则地定位,使得这些间隔沿植入物的纵向延伸彼此对齐地定位。 The same can be advantageously distributed sediment 22,23,24,25,26,27,28,29,30,31 so that their roots in such a manner extending threaded 9.18 to deposits 22, 23, regularly spaced around the central axis of the dental implant positioned between 24,25,26,27,28,29,30,31, so that these intervals along the longitudinal extension of the implant positioned aligned with each other.

[0057] 图10以牙科植入物的形式显示根据本发明植入物部件的实施例的一部分。 [0057] Figure 10 shows a dental implant in the form of embodiment of a portion of the physical components of the implant according to the present invention. 更精确地,图10显示用于连接到人体或动物体活的生物组织的连接装置40。 More precisely, Figure 10 shows a connecting means for connecting to the biological tissue of the human or animal body alive 40. 连接装置40设有至少一个螺纹。 Connecting means 40 is provided with at least one thread. 牙科植入物外表面由钛和/或钛合金构成,并且所述外表面包含至少一个表面区域41,该表面区域41的表面通过形成图案(patterning),例如借助于激光进行表形修改。 The outer surface of the dental implants were made of titanium and / or titanium alloy, and the outer surface 41 comprises at least one surface area, the surface area of the surface 41 by forming a pattern (patterning), such as by means of a laser topography modification. 所述至少一个表面区域41定位在螺纹牙顶43之间的所述至少一个螺纹的根部42。 Wherein said at least one surface region 41 is positioned between the thread crest 43 of at least one thread root 42. 连接装置40的最大直径,即螺纹牙顶43和直径相对的螺纹牙顶之间的距离是3. 75mm,而连接装置40的最小直径是3. 11mm。 The maximum diameter of the connecting means 40, i.e., 43 from the thread crest diameter of the thread crest and between the opposed 3. 75mm, minimum diameter 40 and the connecting means is 3. 11mm. 通过以下方式为该表面区域形成图案:沿根部42纵向延伸一个接一个地设置若干凹陷。 Be formed by the surface area for the pattern: root 42 extends longitudinally arranged one after some depression. 在根部42中,凹陷相当于彼此可横向位移,从而提供轻微的“Z字形”结构。 In the root 42, the recess corresponds to each other laterally displaced, so as to provide a slight "Z-shaped" structure. 该表面区域沿螺纹的至少一圈延伸。 At least one revolution of the surface region extending along the thread.

[0058] 图11显示图10的截面AA,其没有根据比例进行显示。 Cross section AA [0058] Figure 11 shows Fig. 10, which does not display according to the proportion. 该表面区域在连接装置的横截平面上具有波纹形状,其中该波纹形状大致是正弦曲线。 The surface region has a corrugated shape in the cross-sectional plane of the connecting means, wherein the corrugated shape is substantially sinusoidal. 每个波峰45、55比波谷46高出距离50,该距离50不大于200 um,有利地不大于150 um,并且有利地距离50在5和40 um之间,这是在图11中的情况。 Each crest 45, 55 over a distance 50 above the trough 46, the distance 50 is not more than 200 um, advantageously not greater than 150 um, the distance 50 and advantageously between 5 and 40 um, which is the case in FIG. 11 . 两个邻近波峰45、55之间的距离51有利地在50和200iim之间,更有利地在70和150 iim之间,更精确地在90和120iim之间。 Distance 51 is advantageously between 50 and 200iim, more advantageously between 70 and 150 iim, more precisely between 90 and 45, 55 120iim between two adjacent peaks. 然而,在该实施例中距离51是在100和IlOiim之间。 However, in this embodiment, the distance 51 is between 100 and IlOiim. 该表面区域表面的Sa介于1.2和511111之间,其中Sa通过下面等式计算: The surface area of the surface Sa is between 1.2 and 511 111, where Sa by the following equation:

Figure CN101102727BD00081

[0060] 如前面提到的,Sa是用于在植入物技术领域中说明表面粗糙度的公认参数。 [0060] As mentioned previously, Sa is recognized for illustrating surface roughness parameters Technical Field of the implant. 尤其是在发明内容中提到的Ann Wennerberg的论文中公开了Sa的完整定义。 Especially in the Summary of the Invention The Ann Wennerberg mentioned papers disclosed the complete definition Sa. 通过表面区域的该上述表面,能够在骨重塑之后到达完全钙化的骨组织,于是实现所需的生物力学效果。 Through the above-mentioned surface surface area can reach completely calcified bone after bone remodeling, so to achieve the desired effect of biomechanics. 表面区域的所述表面具有表面充分小的修改以便当插入植入物时几乎不导致损伤,但同时它的表面粗糙修改可以提供生物力学效果。 Said surface having a surface area sufficiently small so as to modify the surface when inserting the implant causes little damage, but its surface roughness modified to provide biomechanical effect. 相反,可给出大/粗糙的表面结构,但不完全确定地给出增强的力学效果,而作为插入的结果具有增加的组织损伤,附加地,在骨必须生长的地方提供更长的距离以便达到相同的效果,对于粗糙表面这会导致更长的愈合周期以愈合该组织。 Rather, given the large / rough surface structure, but not entirely sure to give enhanced mechanical effects, and have increased as a result of the insertion of tissue damage, in addition, provide a longer distance in order to grow in the bone must place achieve the same effect, for a roughened surface which can lead to longer healing period to heal the tissue.

[0061] 图12示意性地显示申请人在动物上执行试验研究的结果。 [0061] Figure 12 schematically shows the results of tests performed by the applicant in animal studies. 柱“I”显示了根据本发明用于植入物的去除扭矩,而柱“2”显示了仅以传统方式加工的植入物的去除扭矩。 Column "I" shows the removal torque for the implant according to the present invention, while the column "2" shows the traditional way of working only in the implant removal torque. 此外该研究显示除了根据柱状图的更高的去除扭矩以外,可实现不同的断裂力学,导致明显的骨折。 Further studies have shown that in addition to the outside of the histogram based on the higher removal torque, can achieve different fracture mechanics, led to significant fractures. 这支持了这样的假设,即在去除根据本发明植入物的扭矩后,所需弹性变形与先前观察的以传统方式加工的植入物界面处占优势的塑性变形形成对比。 This supports the hypothesis that the removal torque in accordance with the present invention, after the implant, the desired elastic deformation of the implant previously observed at the interface in a conventional manner processed predominantly plastic deformation contrast.

[0062] 图13显示示意性的图10所示类型的牙科植入物,并图解关于所述至少一个表面区域定位的四个不同的可选方案。 [0062] Figure 13 shows a schematic of the type shown in FIG. 10 of the dental implant, and illustrating the positioning of the at least one surface region of four different options on. 根据第一可选方案Alt.1,沿整个连接装置40设置一个或若干表面区域。 According to a first alternative Alt.1, connecting means 40 is provided along the whole of one or several surface area. 根据第二可选方案Alt. 2,除了紧靠牙科植入物基部47的螺纹第一或第一和第二圈以外,沿螺纹的所有圈设置一个或若干表面区域。 2, in addition to the base portion 47 close to the dental implant threaded to the first or the first and second ring outside, one or several surface regions provided along all threaded ring according to the second alternative Alt. 根据第三可选方案Alt. 3,沿彼此邻近的螺纹的两圈,优选关于牙科植入物基部47的螺纹的第三和第四圈,提供一个或若干表面区域。 3, adjacent to each other along the threaded twice, preferably on the base of the dental implant screw 47 of the third and fourth ring, provided one or several surface area according to a third alternative Alt. 根据第四可选方案Alt. 4,沿仅一个螺纹圈,优选关于牙科植入物基础47的螺纹的第三圈,提供一个或若干表面区域。 4, along only one threaded ring, preferably on the basis of the dental implant screw 47 of the third lap, provided one or several surface area according to a fourth alternative Alt..

[0063] 所述一个或若干表面区域的位置能有利地分别对应图8和图9中的每个表面部的沉积物或多个沉积物。 [0063] The position of the surface area of one or several advantageously correspond in Figures 8 and 9 of each surface portion of the deposit or more deposits.

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