CN100574725C - Promote customization flexible titanium mandibular bone substitute of bone remodeling and preparation method thereof - Google Patents
Promote customization flexible titanium mandibular bone substitute of bone remodeling and preparation method thereof Download PDFInfo
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- CN100574725C CN100574725C CN 200710018365 CN200710018365A CN100574725C CN 100574725 C CN100574725 C CN 100574725C CN 200710018365 CN200710018365 CN 200710018365 CN 200710018365 A CN200710018365 A CN 200710018365A CN 100574725 C CN100574725 C CN 100574725C
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- bone substitute
- bone
- mandibular
- mandibular bone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
Abstract
Promote customization flexible titanium mandibular bone substitute of bone remodeling and preparation method thereof, adopt reverse technology, cad technique, Rapid Prototyping technique, CT picture with the patient is a data source, adopt the design cycle of " CT image/cloud/curved surface/physical model ", profile and structure to the mandibular bone substitute are carried out individuality customization design, and, increase the flexibility of titanium mandibular bone substitute by changing mandibular bone titanium framework body structure, improve because the titanium framework stress shielding problem that causes really up to the mark.The improvement structure of titanium framework is optimized design by finite element, and the ratio that accounts for cumulative volume with the filling bone volume between the best strain regions of human body bone remodeling is as the standard of differentiating the bone substitute flexibility, and the big more flexibility of ratio is good more.This mandibular bone substitute combines facial Physiological Anatomy characteristic of human body jaw and biomechanics characteristic, can significantly improve the corrective surgery effect, effectively reduces doctor's operating time and operation risk, and has that technology is simple, the characteristics of dependable performance.
Description
Technical field
The present invention relates to a kind of mandibular bone substitute, be specifically related to a kind of customization flexible titanium mandibular bone substitute of the promotion bone remodeling based on reverse technology and human lower jawbone biomechanics characteristic.
Background technology
At present, to adopt pure titanium or titanium alloy be matrix material to existing mandibular bone substitute.The designer utilizes reverse technology and 3-D view technology that the computer simulation of whole process is carried out in the reduction of mandibular defect, and the lesion portion of excision skeleton designs corresponding bone substitute.Bone substitute is the U type groove shape of hollow, wherein fills the patient from the body bone, and fixes with extension board.
Titanium has excellent biological compatibility, but its hardness is excessive, elastic modelling quantity (1.14 * 10
5MPa) be about cortical bone (1.37 * 10
4MPa) 10 of elastic modelling quantity times.So under its parcel, the patient can't obtain helping the stress stimulation of bone remodeling from the body bone.Clinical experiment shows that the mandibular bone substitute does not see in the mandibular bone substitute that obviously new bone grows up to after implanting 1 year (the lifelong reconstruction of the bone of generally acknowledging is finished the phase).So the function of existing customization mandibular bone substitute only is embodied in recovers patient's facial appearance, improves the masticatory function aspect, the stress shielding effect that produces behind its implant into body has greatly hindered growing up to of new bone.
Summary of the invention
The objective of the invention is to overcome the shortcoming of above-mentioned prior art, provide a kind of and can not only recover patient's facial appearance, improve masticatory function, and can offer the patient and be of value to the stress stimulation of bone remodeling, thereby promote the customization flexible titanium mandibular bone substitute of the promotion bone remodeling that the patient finishes from the reconstruction of body bone from the body bone.
For achieving the above object, the technical solution used in the present invention is:
1) initial data obtains
At first, the patient who needs is implemented the bone substitute implant surgery by medical spiral CT machine carries out CT scan, and the CT image is carried out multiplanar reconstruction, obtains CT tomography picture;
The design phase of 2) customization type bone substitute
CT tomography picture is carried out pretreatment, and pseudo-shadow and error in the image are proofreaied and correct; Utilize Medical Image Processing software that the CT image after proofreading and correct is reconstructed, obtain the pathological model of patient's mandibular defect situation; Cad model by this pathological model design bone substitute, bone substitute becomes the U type groove shape of hollow, two ends are connected with bone stump by extension board, body U-lag top flushes with lower jaw sound of baby talk root, the extension board top is a little less than U-lag, the long 15mm of this extension board offers the staple hole that three apertures are 2mm on the extension board;
3) finite element optimization analysis
The characteristic of extracting above-mentioned customization type bone substitute is to its parametric modeling, flexible structure at its body design can promotion bone remodeling, the analog bone substitute is at the intravital normal physiological environment of people, utilize Finite Element Method to be optimized analysis, and formulate evaluation criterion and analyze, judge optimizing the result; Finite element analysis simulation lower jaw central occlusion state is supposed the prosthese fixation, and no relative displacement is carried out full degree of freedom constraint to the screw hole inner surface, and load is converted into the loading of face stress form according to the interlock masticatory force in tooth position district, and its concrete size sees Table 1
The material parameter of mandibular bone substitute sees Table 2
Aspect of model data: the mandibular bone outside is camber line equation Y=aX down
2, mandibular bone substitute body U-lag structural profile trajectory equation Y=bZ
2, the value of a, b is measured by the cad model that customizes bone substitute;
Flexible structure: on mandibular bone substitute body, offer hole or back-shaped groove, wherein, the design main points of back-shaped groove are: the mandibular bone titanium framework is put in the intravital normal position of people by it, alternately slot from upper and lower two directions at its body, the direction of groove is determined with the human body coordinate axes that systematic anatomy defines, its x direction is parallel to horizontal plane, the y direction becomes certain angle of cut with the human body sagittal plane, the size at angle can be chosen arbitrarily between 0 °-180 ° according to the individual patients situation, and the z direction is the method direction of the bone substitute curved surface of bottom land central point;
4) estimate optimization: the finite element optimization analysis result of above-mentioned flexible structure is estimated, obtain optimal value, in the ANSYS analysis software, divide grid setting uniform-dimension to filling bone model, set up the cell list array, statistical is carried out in each unitary strain, the ratio that 0.0015～0.005 filling bone volume accounts for cumulative volume between wherein best strain regions is designated as P, and P is big more, and flexibility is good more; Consider the maximum stress SMAX of bone substitute when interlock is carried simultaneously, enough for guaranteeing bone substitute intensity, this stress value should not be higher than 550MPa; Estimate the optimization result of the flexible structure of above-mentioned bone substitute with these data;
5) on the cad model of customization type mandibular bone substitute, design flexible pore structure, time type groove structure or the hole slot integrated structure that can promote bone remodeling according to estimating the optimization result, adopt Rapid Prototyping technique and melted module precise casting technology to make the mandibular bone substitute.
Mandibular bone substitute of the present invention adopts pure titanium or titanium alloy to make.
Mandibular bone substitute of the present invention comprises the mandibular bone substitute and is filled in spongy bone in the mandibular bone substitute body 3, the trajectory Z=aX of the XZ face of this mandibular bone substitute
2YZ facial bone substitute body section trajectory equation Y=bZ
2The value of a, b is measured by the cad model that customizes bone substitute; Mandibular bone substitute body both sides respectively are provided with the extension board of a long 15mm, and offer the staple hole that three apertures are 2mm on this extension board 2; Offer hole or back-shaped groove on mandibular bone substitute body, the position of its hole or back-shaped groove and physical dimension utilize Finite Element Method to be optimized analysis according to the characteristic of patient's mandibular bone, and analyze, judge acquisition according to evaluation criterion to optimizing the result.
The present invention is by extracting patient's CT image, design by cad technique and individual customization of RP technology, can not only recover patient's facial appearance, improve masticatory function, and can offer the patient and be of value to the stress stimulation of bone remodeling from the body bone, promote that the patient finishes from the reconstruction of body bone.
Description of drawings
Fig. 1 is the cad model figure of the back-shaped groove structural flexibility of the present invention titanium mandibular bone substitute;
Fig. 2 is the structural representation of the back-shaped groove 4 of the present invention, and wherein B is a groove width, and D is a separation, and H is the groove height, and θ is the angle of inclination of groove, and L is long for the titanium framework body;
Fig. 3 is the cad model figure of pore structure flexible titanium mandibular bone substitute of the present invention;
Fig. 4 is the design parameter figure of pore structure 6 of the present invention, and wherein R is the aperture, and D is a pitch of holes, and L is long for the titanium framework body.
Fig. 5 is the cad model figure of hole slot structural flexibility titanium mandibular bone substitute of the present invention.
The specific embodiment
Below in conjunction with accompanying drawing the present invention is described in further detail
Embodiment 1, the present invention includes mandibular bone substitute 2 and is filled in spongy bone 3 in the mandibular bone substitute 2, the trajectory Z=aX of the XZ face of this mandibular bone substitute 2 referring to Fig. 1,2
2, a=0.0246; YZ face prosthese body section trajectory equation Y=bZ
2, medial surface b=0.25, lateral surface b=0.2; Mandibular bone substitute 2 both sides respectively are provided with the extension board 1 of a long 15mm, and the staple hole 5 that to offer three apertures on this extension board 1 be 2mm; Offer back-shaped groove 4 on mandibular bone substitute 2, the groove width B of back-shaped groove 4 is 3mm, and long H is 12mm, and space D is 5mm; The inclination angle [theta] of groove is 30 °.
Its manufacture method is as follows:
1) initial data obtains
At first, the patient who needs is implemented the bone substitute implant surgery by medical spiral CT machine carries out CT scan, and the CT image is carried out multiplanar reconstruction, obtains CT tomography picture;
The design phase of 2) customization type bone substitute
CT tomography picture is carried out pretreatment, and pseudo-shadow and error in the image are proofreaied and correct; Utilize Medical Image Processing software that the CT image after proofreading and correct is reconstructed, obtain the pathological model of patient's mandibular defect situation; Cad model by this pathological model design bone substitute, bone substitute becomes the U type groove shape of hollow, two ends are connected with bone stump by extension board, body U-lag top flushes with lower jaw sound of baby talk root, the extension board top is a little less than U-lag, the long 15mm of this extension board, on staple hole that to offer three apertures be 2mm;
3) finite element optimization analysis
The characteristic of extracting above-mentioned customization type bone substitute is to its parametric modeling, flexible structure at its body design can promotion bone remodeling, the analog bone substitute is at the intravital normal physiological environment of people, utilize Finite Element Method to be optimized analysis, and formulate evaluation criterion and analyze, judge optimizing the result;
Sting and state finite element analysis simulation lower jaw center, supposes the prosthese fixation, and no relative displacement is carried out full degree of freedom constraint to the screw hole inner surface, and load is converted into the loading of face stress form according to the interlock masticatory force in tooth position district, and its concrete size sees Table 1
The material parameter of mandibular bone substitute sees Table 2
Aspect of model data: the mandibular bone outside is camber line equation y=aX down
2, mandibular bone substitute body U-lag structural profile trajectory equation Y=bZ
2, a=0.0246 in the present embodiment; Medial surface b=0.25, lateral surface b=0.2;
Flexible structure: on mandibular bone substitute body, offer hole or back-shaped groove, wherein, the design main points of back-shaped groove are: the mandibular bone titanium framework is put in the intravital normal position of people by it, alternately slot from upper and lower two directions at its body, the direction of groove is determined with the human body coordinate axes that systematic anatomy defines, its x direction is parallel to horizontal plane, the y direction becomes certain angle of cut with the human body sagittal plane, the size at angle can be chosen arbitrarily between 0 °-180 ° according to the individual patients situation, and the z direction is the method direction of the bone substitute curved surface of bottom land central point;
4) estimate optimization: the finite element optimization analysis result of above-mentioned flexible structure is estimated, obtain optimal value, in the ANSYS analysis software, divide grid setting uniform-dimension to filling bone model, set up the cell list array, statistical is carried out in each unitary strain, the ratio that 0.0015～0.005 filling bone volume accounts for cumulative volume between wherein best strain regions is designated as P, and P is big more, and flexibility is good more; Consider the maximum stress SMAX of bone substitute when interlock is carried simultaneously, enough for guaranteeing bone substitute intensity, this stress value should not be higher than 550MPa; Estimate the optimization result of the flexible structure of above-mentioned bone substitute with these data;
5) on the cad model of customization type mandibular bone substitute, design flexible pore structure, time type groove structure or the hole slot integrated structure that can promote bone remodeling according to estimating the optimization result, adopt Rapid Prototyping technique and melted module precise casting technology to make the mandibular bone substitute, it is the material of mandibular bone substitute 2 that this mandibular bone substitute adopts titanium alloy TC 4, and in the mandibular bone substitute, fill the patient from body spongy bone 3, the extension board 1 of one long 15mm respectively is set in mandibular bone substitute 2 both sides, and the staple hole 5 that to offer three apertures on this extension board 1 be 2mm; Offer back-shaped groove 4 on mandibular bone substitute 2, the groove width of back-shaped groove 4 is 3mm, and long is 12mm, and spacing is 5mm; The inclination angle of groove is 30 °.
Embodiment 2: referring to Fig. 3,4, present embodiment is to offer hole 6 on mandibular bone substitute 2, and the diameter R in hole 6 is 3mm, and left and right sides pitch-row D is 4mm, and pitch-row is 2.5mm up and down.Other structure and manufacture method are with embodiment 1.
Embodiment 3, and referring to Fig. 5, the present invention can also adopt hole 6 and back-shaped groove 4 structure combining.
Claims (3)
1, promote the preparation method of the customization flexible titanium mandibular bone substitute of bone remodeling, it is characterized in that:
1) initial data obtains
At first, the patient who needs is implemented the bone substitute implant surgery by medical spiral CT machine carries out CT scan, and the CT image is carried out multiplanar reconstruction, obtains CT tomography picture;
The design phase of 2) customization type bone substitute
CT tomography picture is carried out pretreatment, and pseudo-shadow and error in the image are proofreaied and correct; Utilize Medical Image Processing software that the CT image after proofreading and correct is reconstructed, obtain the pathological model of patient's mandibular defect situation; Cad model by this pathological model design bone substitute, bone substitute becomes the U type groove shape of hollow, two ends are connected with bone stump by extension board, body U-lag top flushes with lower jaw sound of baby talk root, the extension board top is a little less than U-lag, the long 15mm of this extension board offers the staple hole that three apertures are 2mm on the extension board;
3) finite element optimization analysis
The characteristic of extracting above-mentioned customization type bone substitute is to its parametric modeling, flexible structure at its body design can promotion bone remodeling, the analog bone substitute is at the intravital normal physiological environment of people, utilize Finite Element Method to be optimized analysis, and formulate evaluation criterion and analyze, judge optimizing the result; Finite element analysis simulation lower jaw central occlusion state is supposed the prosthese fixation, and no relative displacement is carried out full degree of freedom constraint to the screw hole inner surface, and load is converted into the loading of face stress form according to the interlock masticatory force in tooth position district, and its concrete size sees Table 1
The material parameter of mandibular bone substitute sees Table 2
Aspect of model data: the mandibular bone outside is camber line equation Y=aX down
2, mandibular bone substitute body U-lag structural profile trajectory equation Y=bZ
2, the value of a, b is measured by the cad model that customizes bone substitute;
Flexible structure: on mandibular bone substitute body, offer hole or back-shaped groove, wherein, the design main points of back-shaped groove are: the mandibular bone titanium framework is put in the intravital normal position of people by it, alternately slot from upper and lower two directions at its body, the direction of groove is determined with the human body coordinate axes that systematic anatomy defines, its x direction is parallel to horizontal plane, the y direction becomes certain angle of cut with the human body sagittal plane, the size at angle can be chosen arbitrarily between 0 °-180 ° according to the individual patients situation, and the z direction is the method direction of the bone substitute curved surface of bottom land central point;
4) estimate optimization: the finite element optimization analysis result of above-mentioned flexible structure is estimated, obtain optimal value, in the ANSYS analysis software, divide grid setting uniform-dimension to filling bone model, set up the cell list array, statistical is carried out in each unitary strain, the ratio that 0.0015～0.005 filling bone volume accounts for cumulative volume between wherein best strain regions is designated as P, and P is big more, and flexibility is good more; Consider the maximum stress SMAX of bone substitute when interlock is carried simultaneously, enough for guaranteeing bone substitute intensity, this stress value should not be higher than 550MPa; Estimate the optimization result of the flexible structure of above-mentioned bone substitute with these data;
5) on the cad model of customization type mandibular bone substitute, design flexible pore structure, time type groove structure or the hole slot integrated structure that can promote bone remodeling according to estimating the optimization result, adopt Rapid Prototyping technique and melted module precise casting technology to make the mandibular bone substitute.
2, the preparation method of the customization flexible titanium mandibular bone substitute of promotion bone remodeling according to claim 1, it is characterized in that: described mandibular bone substitute adopts pure titanium or titanium alloy to make.
3, a kind of customization flexible titanium mandibular bone substitute that promotes bone remodeling comprises mandibular bone substitute (2) and is filled in the interior spongy bone (3) of mandibular bone substitute (2), it is characterized in that: the trajectory Z=aX of the XZ face of this mandibular bone substitute (1)
2YZ facial bone substitute body section trajectory equation Y=bZ
2The value of a, b is measured by the cad model that customizes bone substitute; Mandibular bone substitute (2) both sides respectively are provided with the extension board (1) of a long 15mm, and offer the staple hole (5) that three apertures are 2mm on this extension board (1); On mandibular bone substitute (2), offer hole (6) or back-shaped groove (4), the position of its hole or back-shaped groove and physical dimension utilize Finite Element Method to be optimized analysis according to the characteristic of patient's mandibular bone, and analyze, judge acquisition according to evaluation criterion to optimizing the result.
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| CN 200710018365 CN100574725C (en) | 2007-07-27 | 2007-07-27 | Promote customization flexible titanium mandibular bone substitute of bone remodeling and preparation method thereof |
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| CN 200710018365 CN100574725C (en) | 2007-07-27 | 2007-07-27 | Promote customization flexible titanium mandibular bone substitute of bone remodeling and preparation method thereof |
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| CN100574725C true CN100574725C (en) | 2009-12-30 |
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Cited By (1)
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| TWI813447B (en) * | 2022-09-20 | 2023-08-21 | 國立陽明交通大學 | Jaw prosthesis |
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| CN102073764B (en) * | 2011-01-07 | 2012-10-10 | 中国科学院计算技术研究所 | Automatic finite element modeling method of dentognathic system and system thereof |
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| CN103784219A (en) * | 2014-02-27 | 2014-05-14 | 西安交通大学 | Method for manufacturing titanium plate mandible prosthesis with flexible three-dimension structure |
| EP3345560B1 (en) * | 2014-07-09 | 2022-03-16 | DePuy Synthes Products, Inc. | Flexible maxillo-mandibular fixation device |
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| CN110575287B (en) * | 2018-06-11 | 2022-04-05 | 衢州市人民医院 | Mandibular implant and method of making same |
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| CN111494061A (en) * | 2020-04-22 | 2020-08-07 | 西安交通大学 | Personalized mandible substitute compounded with autologous bone |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI813447B (en) * | 2022-09-20 | 2023-08-21 | 國立陽明交通大學 | Jaw prosthesis |
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Application publication date: 20080109 Assignee: Initiate three-dimensional medical science and technology company limited in Ningbo Assignor: Xi'an Jiaotong University Contract record no.: 2015610000081 Denomination of invention: Promoting bone reconstruction custom flexible titanium lower jawbone substitute and its preparation method Granted publication date: 20091230 License type: Common License Record date: 20150814 |
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