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Publication numberCN100443128 C
Publication typeGrant
Application numberCN 200480011780
PCT numberPCT/EP2004/002115
Publication date17 Dec 2008
Filing date3 Mar 2004
Priority date3 Mar 2003
Also published asCA2517741A1, CA2517741C, CA2518013A1, CA2518013C, CN1780652A, DE202004021390U1, DE202004021469U1, DE202004021470U1, DE602004013558D1, DE602004016298D1, DE602004019351D1, DE602004031309D1, EP1603610A1, EP1603610B1, EP1603611A1, EP1603611B1, EP1920794A1, EP1920794B1, EP1974761A2, EP1974761A3, EP1974761B1, EP2011531A2, EP2011531A3, EP2011531B1, EP2263721A2, EP2263721A3, EP2263721B1, EP2263722A2, EP2263722A3, EP2263722B1, EP2263723A2, EP2263723A3, EP2263723B1, EP2263724A2, EP2263724A3, EP2263724B1, EP2266648A2, EP2266648A3, EP2266648B1, EP2281592A2, EP2281592A3, EP2281592B1, EP2283886A2, EP2283886A3, EP2283886B1, US7850662, US7918833, US7935088, US8512297, US8556864, US8603044, US8679069, US8992486, US9011391, US9028454, US9233211, US9408979, US9526844, US9533105, US9561331, US9604008, US9604009, US9610409, US9623189, US9623190, US9775954, US20040267208, US20050033244, US20060264839, US20070093761, US20090198193, US20110152784, US20110178474, US20110276009, US20120089100, US20130267906, US20130274680, US20130304024, US20140316344, US20140316345, US20140316346, US20140316347, US20140316348, US20140316349, US20140316374, US20150174334, US20160074590, US20160256633, US20160296708, US20160303329, WO2004078239A1, WO2004078241A1
Publication number200480011780.4, CN 100443128 C, CN 100443128C, CN 200480011780, CN-C-100443128, CN100443128 C, CN100443128C, CN200480011780, CN200480011780.4, PCT/2004/2115, PCT/EP/2004/002115, PCT/EP/2004/02115, PCT/EP/4/002115, PCT/EP/4/02115, PCT/EP2004/002115, PCT/EP2004/02115, PCT/EP2004002115, PCT/EP200402115, PCT/EP4/002115, PCT/EP4/02115, PCT/EP4002115, PCT/EP402115
InventorsDA普伦普特里, RF维齐, R珀金斯
Applicant塞诺菲-安万特德国有限公司
Export CitationBiBTeX, EndNote, RefMan
External Links: SIPO, Espacenet
Drive mechanish for drug delivery devices.
CN 100443128 C
Abstract  translated from Chinese
一种用于给药装置的驱动机构,包括:具有螺旋螺纹优选地为内部螺旋螺纹的壳体;具有与所述壳体的螺旋螺纹相接合的螺旋螺纹的剂量标度套管(70);可释放地连接到所述剂量标度套管(70)的驱动套管(30);以及位于该剂量标度套管(70)和驱动套管(30)之间的离合器装置(60)。 A drive mechanism for a drug delivery device, comprising: a helical thread preferably having internal helical thread of the housing; the housing having a helical thread engaged with the helical thread of the dose dial sleeve (70); is releasably connected to said dose dial sleeve (70) of the drive sleeve (30); and a clutch means located within the dose dial sleeve (70) and the drive sleeve (30) between (60). 当该剂量标度套管(70)和驱动套管(30)联接时,允许该两者相对于该壳体旋转。 When the dose dial sleeve (70) and the drive sleeve (30) is coupled, allowing the two rotation relative to the housing. 当该剂量标度套管(70)和驱动套管(30)断开联接时,允许该剂量标度套管(70)相对于该壳体旋转,但不允许该驱动套管(30)相对于该壳体旋转,其中允许该驱动套管(30)进行轴向运动以便沿纵向方向将力传递到给药装置的近端。 When the dose dial sleeve (70) and the drive sleeve (30) is coupled off, allowing the dose dial sleeve (70) with respect to the rotating housing, but does not allow the drive sleeve (30) relative to rotation in the housing, which allow the drive sleeve (30) so that axial movement of the force transmission in the longitudinal direction to the proximal end of the drug delivery device.
Claims(12)  translated from Chinese
1.一种用于给药装置的驱动机构,包括: 具有螺旋螺纹的壳体; 具有与所述壳体的螺旋螺纹相接合的螺旋螺纹的剂量标度套管; 可释放地连接到所述剂量标度套管的驱动套管;以及位于该剂量标度套管和驱动套管之间的离合器装置;其特征在于, a)当该剂量标度套管和驱动套管联接时,允许该剂量标度套管和驱动套管两者相对于该壳体旋转;以及b)当该剂量标度套管和驱动套管断开联接时,允许该剂量标度套管相对于该壳体旋转,但不允许该驱动套管相对于该壳体旋转,其中允许该驱动套管进行轴向运动以便沿纵向方向将力传递到给药装置的近端。 1. A drive mechanism for a drug delivery device, comprising: a housing having a helical thread; said housing having a helical thread engaged with the helical thread of the dose dial sleeve; releasably connected to the dose dial sleeve of the drive sleeve; and clutch means located within the dose dial sleeve and the drive sleeve between; characterized in that, a) when the dose dial sleeve and the drive sleeve coupling, allowing the the dose dial sleeve and the drive sleeve with respect to both the housing rotation; and b) when the dose dial sleeve and the drive sleeve to disconnect, allowing the dose dial sleeve with respect to the housing rotation , but does not allow the drive sleeve with respect to the rotating housing, which allows the axial movement of the drive sleeve in the longitudinal direction so that the force is transmitted to the proximal end of the delivery device.
2. 根据权利要求1的驱动机构,其特征在于,该驱动机构包括活塞杆,该活塞杆适于穿过该壳体操作,并沿所述纵向方向将所述力传递到该给药装置的近端。 The drive mechanism as claimed in claim 1, characterized in that the drive mechanism comprises piston rod adapted to operate through the housing and along the longitudinal direction of the force is transmitted to the delivery device proximal end.
3. 根据权利要求1的驱动机构,其特征在于,所述剂量标度套管还包括螺旋螺紋,该螺紋的导程与所述驱动套管的螺旋螺紋的导程相同。 3. The drive mechanism according to claim 1, wherein said dose dial sleeve further comprises a helical thread, the lead screw thread with the helical thread of the drive sleeve in the same lead.
4. 根据权利要求2的驱动机构,其特征在于,所述活塞杆设计成附装有一齿轮,该齿轮设计成与该驱动套管的螺紋以及一齿条的齿相啮合,其中所述齿条固定在该壳体上。 4. A drive mechanism according to claim 2, wherein said piston rod is designed to be attached is provided with a gear which is designed to engaged with the driving of the threaded sleeve and the teeth of a rack, wherein the rack fixed to the housing.
5. 根据权利要求1的驱动机构,其特征在于,所述壳体的螺旋螺紋是内部螺旋螺紋。 5. A drive mechanism according to claim 1, wherein said helical thread is an internal helical thread of the housing.
6. —种用于给药装置的组件,包含权利要求1所述的驱动机构。 6. - Species assembly for administering apparatus, comprising a drive mechanism according to claim 1, wherein.
7. —种给药装置,包含权利要求1所述的驱动机构或权利要求6所述的组件。 7. - seed delivery device, comprising the drive mechanism according to claim 1 or claim 2 or claim 6, wherein the assembly.
8. 根据权利要求7的给药装置,其特征在于,该给药装置是笔型装置。 8. A drug delivery device according to claim 7, characterized in that the administration means is a pen-type device.
9. 根据权利要求7的给药装置,其特征在于,该给药装置是注射器类型的装置。 9. The drug delivery device according to claim 7, characterized in that the administration means is a syringe type device.
10. 根据权利要求7的给药装置,其特征在于,该给药装置包含针头。 10. A drug delivery device according to claim 7, characterized in that the administering device comprises a needle.
11. 根据权利要求7的给药装置,其特征在于,该给药装置是不带针头的装置。 11. A drug delivery device according to claim 7, characterized in that the administration device is a device without needle.
12. —种制造或组装给药装置的方法,该方法包括提供权利要求1所述的驱动机构或权利要求6所述的组件的步骤。 12. - Species manufacture or assembly of the drug delivery device, the method comprising the step of providing a drive mechanism according to claim 1 or claim 2 or claim 6 wherein the assembly.
Description  translated from Chinese

用于给药装置的驱动机构技术领域本发明涉及适用于给药装置(药品输送装置)尤其是笔型注射器的驱动机构,该驱动机构具有剂量设定装置,从而使得可从多次剂量的药筒进行药品的给药。 TECHNICAL FIELD The drive mechanism for administration of the present invention relates to a device suitable for administration (drug delivery device) in particular pen-type injector drive mechanism, the drive mechanism having a dose setting device, so that multiple doses of the drug can be from cylinder administered drugs. 具体地,本发明涉及其中用户可设定剂量的给药装置。 In particular, the present invention relates to where the user can set the dose administering device. 背景技术这种给药装置应用于由未受到正规医学培训的人员即患者进行定时注射的场合。 BACKGROUND such administration device is applied to formal medical training by a person that is not subject to the timing of injections patients occasion. 这在患有糖尿病的患者中越来越普遍,自我治疗使得这种人员可对他们的糖尿病进行有效的用药。 This is more common in patients with diabetes, self-treatment enables such persons can effectively manage their diabetes medication. 这些情况为这种给药装置提出了许多要求。 The case made a number of means such administration requirements. 这种装置的结构必须坚固, 并且就部件的操作以及使用者对其操作和所需剂量药品的输送的理解来说,要易于使用。 Construction of such a device must be strong, and to operate and user understanding of its operation and components required dose drug delivery, it should be easy to use. 剂量设定必须容易且明确。 Dose setting must be easy and unambiguous. 在使用者患有糖尿病的情况下,许多使用者体质弱且还可能视力减退,这就要求该驱动机构具有较低的分配力,且剂量设定显示器易于读取。 In the case of a user with diabetes, many users may also be weak constitution and vision loss, which requires that the drive mechanism has a lower distribution power, and easy to read dose setting display. 在该装置是一次性的而不是可重复使用的情况下,该装置的制造应便宜,且易于处理(优选地适于回收)。 In this device it is not the case and under the disposable, reusable, the device should be inexpensive manufacture and easy to handle (preferably suitable for recycling). 为了满足这些要求,组装该装置所需的部件的数量以及制造该装置的材料种类的数量需要保持最小。 To meet these requirements, the number and the number of the manufacturing apparatus of the type of material required for assembling the components of the apparatus needs to maintain a minimum. 由使用者操作的给药装置在医药领域内是公知的。 Dosing device operated by a user in the pharmaceutical field is known. US 5304152中公开了一种分配装置,其体部长度与活塞长度的比率是大约1:1以便可分配较大的剂量。 US 5304152 discloses a dispensing apparatus, the ratio of Length of the piston body and its length is approximately 1: 1 so as to be assigned a larger dose. 尽管此种装置比现有技术有了很大改进, 但是在既不分配设定量的流体又不拆开药筒的条件下容易地对过剂量的设定进行改正的问题仍没有解决。 Although this means a great improvement over the prior art, but in neither allocated a set amount of fluid conditions without open cartridge easily overdose is set to correct the problem is not solved. W09938554A2提出一种从药筒中分配设定剂量的药品的注射器,其中公开了一种包括单向联接件(即棘轮)的驱动机构,该驱动机构允"^午改正设定的过多剂量而不需要分配该设定量的流体或需要拆开该药筒。令人惊讶的是,已发现不具有单向联接件的根据本发明的驱动机构为驱动机构提供了一种有价值的技术方案,其中致动该机构所需的力减小。 这可通过引入本发明所限定的离合器装置来实现。根据本发明的驱动机构还具有直观和容易使用以改正设定的剂量的优点。发明内容根据本发明的第一个方面,提供一种用于给药装置的驱动机构,包括: 具有螺旋螺紋的壳体;具有与所述壳体的螺旋螺紋相接合的螺旋螺紋的剂量标度套管; 可释放地连接到所述剂量标度套管的驱动套管;以及位于该剂量标度套管和驱动套管之间的离合器装置; 其特征在于,a) 当该剂量标度套管和驱动套管联接时,允许该剂量标度套管和驱动套管相对于该壳体旋转;以及b) 当该剂量标度套管和驱动套管断开联接时,允许该剂量标度套管相对于该壳体旋转,而不允许该驱动套管相对于该壳体旋转,其中允许该驱动套管进行轴向运动,从而沿纵向方向向该给药装置的近端传递力。在本发明的驱动机构的一优选实施例中,所述驱动机构还包括一活塞杆,该活塞杆适于穿过该壳体操作,并沿所述纵向方向将所述力传递给该给药装置的近端。在本发明的驱动机构的另一优选实施例中,所述剂量标度套管还包括螺旋螺紋,该螺紋的导程与所述驱动套管的螺紋的导程相同。在本发明的一更具体的实施例中,该驱动机构还包括一螺母,其可相对于该驱动套管旋转并可轴向移动,但是不能相对于该壳体旋转。根据本发明的术语"给药装置"是指设计成用于分配选定剂量的药品(优选地是多次选定剂量)例如胰岛素、生长激素、低分子量肝素以及它们的类似物和/或衍生物等的单次剂量或多次剂量的、 一次性的或可重复使用的装置。所述装置可以是任何类型的,例如小型或笔型。可通过机械(任选地,手动)或电力驱动机构或储能驱动机构例如弹簧等来实现剂量输送。 可通过手动机构或电子机构来实现剂量选择。另外,所迷装置可包括i殳计成用于监控生理特性例如血糖等级等的元件。而且,所迷装置可包括^l十头或者没有针头。特别地,术语"给药装置"是指具有机械和手动剂量输送和剂量选择机构的一次性的、多次剂量的笔型装置,该装置设计成可由没有受过正规医学训练的人例如患者定时使用。优选地,给药装置是注射器型的。根据本发明的术语"壳体"优选地是指具有螺旋螺紋的任何外部壳体("主壳体"、"体部"、"壳")或内部壳体("插入件"、"内体部")。 W09938554A2 proposes a set dose of drug dispensing from a syringe cartridge, which is disclosed comprising a unidirectional coupling (i.e., a ratchet) drive mechanism, the drive mechanism allows "^ Kenneth excessive dose setting without correction The need to allocate a set amount of fluid or the need to disassemble the drug cartridge. Surprisingly, it has been found not to have unidirectional coupling provides a valuable technical solution for the drive mechanism according to the driving mechanism of the present invention, wherein the actuating mechanism required to reduce the force. This is achieved by the introduction of a clutch means as defined in the present invention is achieved. also has an intuitive and easy to use to set the correct dose of the advantages according to the driving mechanism of the present invention. According to A first aspect of the present invention, there is provided a drive mechanism for a drug delivery device, comprising: a housing having a helical thread; dose scale of the housing having a helical thread engaged with the helical thread of the sleeve; releasably connected to the dose dial sleeve of the drive sleeve; and a clutch means the dose dial sleeve and the drive sleeve between; characterized in that, a) when the dose dial sleeve and the drive the sleeve coupling, allowing the dose dial sleeve and the drive sleeve with respect to the housing rotation; and b) when the dose dial sleeve and the drive sleeve to disconnect, allowing the dose dial sleeve relative rotation in the housing, which does not allow the drive sleeve with respect to the rotating housing, which allows the axial movement of the drive sleeve, so that the longitudinal direction to the proximal end of the force transmitting administration device. In the present invention, the proximal end of the drive mechanism of a preferred embodiment, the drive mechanism further comprises a piston rod adapted to operate through the housing and along the longitudinal direction of the force transmitted to the delivery device In another preferred embodiment of the drive mechanism of the present invention, the dose dial sleeve further comprises a helical thread, the lead screw and the thread of the drive sleeve lead the same. In one of the present invention more specific embodiment, the drive mechanism further comprises a nut which is movable relative to the rotary drive sleeve and axially movable, but not with respect to the rotation of the housing. According to the present invention, the term "drug delivery device" is It means designed for dispensing the selected drug dose (preferably multiple selected doses) such as a single dose of insulin, growth hormone, low molecular weight heparins, and their analogues and / or derivatives or multiple dose , disposable or reusable device. The device may be any type, such as small or pen-type. by mechanical (optionally manual) or electrical drive mechanism or stored energy drive mechanism such as a spring or the like to achieve dose delivery can be via a manual mechanism or electronic mechanism to achieve dose selection. In addition, the fan means may comprise i Shu meter such as blood glucose levels, etc. into the device for monitoring physiological characteristics. Furthermore, the fan means may comprise first ten or ^ l no needles. In particular, the term "drug delivery device" refers to a one-time, multi-dose pen-type device having mechanical and manual dose delivery and dose selection mechanisms, the device is designed to be no formal medical training people such as patients regularly use. Preferably, the drug delivery device is a syringe-type. According to the present invention, the term "housing" shall preferably mean any exterior housing having a helical thread ("main housing", "body", "shell ") or interior housing (" insert "," inner body "). 该壳体设计成使得能够安全、正确和舒适地操纵该给药装置或其任何机构。 The housing designed to enable safe, accurate and comfortable handling of the drug delivery device or any agency thereof. 通常,该壳体设计成通过对暴露于污染物例如液体、灰尘、污垢等进行限制来容纳、固定、保护、引导和/或接合该给药装置的任何内部元件(例如驱动机构、药筒、活塞、活塞杆)。 Typically, the housing is designed by exposure to contaminants such as liquid, dust, dirt and other restrictions to accommodate, fixing, protection, and any internal guide element (e.g. the drive mechanism, cartridge of the administering device and / or joined, piston, piston rod). 通常,该壳体可以是管形或非管形的一体的或多部件的元件。 Typically, the housing may be of tubular or non-tubular or multi-element integral member. 通常,该外部壳体用于容纳药筒,可从该药筒分配多种剂量的药品。 Typically, the outer housing for receiving the cartridge, you can assign multiple doses of the drug from the drug cartridge. 在本发明的一更具体的实施例中,该外部壳体具有多个最大剂量止动件,该止动件适于被设置在该剂量标度套管上的径向止动件紧靠于其上。 In a more specific embodiment of the present invention, the outer housing having a plurality of maximum dose stops, the stopper member is adapted to radial stop provided on the dose dial sleeve abuts in on it. 优选地,至少一个该最大剂量止动件包括位于螺旋螺紋和设置在壳体的第二端处的花键装置之间的径向止动件。 Preferably, at least one of the maximum dose stops comprises a helical thread and spline means provided between the second end of the housing of the movable stopper member radially. 可选择地,至少一个该最大剂量止动件包括设置在该壳体的第二端处的抬高的窗口部分的一部分。 Alternatively, at least one of the maximum dose stops comprises a raised window portion provided at a second end portion of the housing. 根据本发明的术语"接合的"尤其是指该驱动机构/给药装置的两个或更多元件的联锁,例如花键、螺紋或啮合的齿的连接,优选地是元件的螺旋螺紋的联锁("螺紋接合")。 According to the present invention, the term "engagement" in particular refers to the interlocking of two or more elements of the drive mechanism / drug delivery device, such as a spline, thread, or meshed teeth connection, preferably a helical thread element Interlock ("thread engagement"). 根据本发明的术语"螺旋螺紋"优选地是指位于给药装置的元件的内部和/或外部表面上的全螺紋或部分螺紋,例如圆柱形螺旋肋部/凹槽,其横截面基本为三角形或方形或圆形,并i殳计成允许在元件之间进行连续的自由旋转和/或轴向运动。 According to "screw thread" of the present invention, the term preferably refers to administering device located inside the element and / or all or part of the threads on the threaded outer surface, e.g., a cylindrical spiral rib / groove, is substantially triangular in cross-section or square or round, and i Shu meter between the elements to allow continuous free rotational and / or axial movement. 任选地,螺紋还可设计成阻止特定的元件沿一个方向发生凝)争运动或轴向运动。 Optionally, a thread may also be designed to block specific elements occur in one direction condensate) contention motion or axial motion. 根据本发明的术语"剂量标度套管"是指其橫截面基本为圓形的基本为管形的元件,包括:a) 内部和外部螺紋,或b) 内部螺紋,或c) 外部螺紋,优选地,根据本发明的剂量标度套管包括螺旋螺紋,该螺紋的导程接近且优选地等于驱动套管的螺;旋螺紋的导程。 According to the present invention, the term "dose dial sleeve" refers to a substantially circular cross-section of a substantially tubular member, comprising: a) internal and external thread, or b) an internal thread, or c) an external thread, Preferably, the dose dial sleeve according to the present invention comprises a helical thread, the thread lead nearly equal to and preferably helical drive sleeve; lead screw threads. 在另一个优选实施例中,该剂量标度套管设计成用于指示选定剂量的可分配的药品。 In another preferred embodiment, the dose dial sleeve is designed to indicate a selected dose of the drug can be allocated. 这可通过使用例如印制在剂量标度套管的外表面上的标记、符号、数字等或测距器或类似物来实现。 This can be printed by using, for example a dose dial sleeve outer surface markers, symbols, numbers, or the like range finder, or the like to achieve. 在本发明的一更具体的实施例中,剂量标度套管具有多个径向延伸的构件,该构件适于紧靠设置在该壳体的笫二端的对应的多个径向止动件。 In a more specific embodiment of the present invention, the dose dial sleeve having a plurality of radially extending member, the member is adapted to abut a corresponding plurality of radially disposed on the second end of the housing Zi stopper . 根据本发明的术语"导程"优选地是指螺母在旋转一整圏时前进的轴向距离;优选地,"导程"是指驱动机构的具有螺旋螺紋的元件,即剂量标度套管、驱动套管、活塞杆等在一次旋转期间行进的轴向距离。 According to the present invention, the term "lead" preferably refers to the nut in the axial distance rings of one complete rotation when forward; preferably "lead" refers to the component having a helical thread of the drive mechanism, namely the dose dial sleeve During travel, drive sleeve, piston rod, etc. in a rotating axial distance. 因此, 导程与相关元件的螺紋的螺距有关。 Therefore, lead and pitch of the threads associated components related. 根据本发明的术语"螺距"优选地是指平行于螺旋螺紋的轴线测量出的螺旋螺紋上的连续轮廓之间的距离。 According to the present invention, the term "pitch" preferably refers to the distance between consecutive contour parallel to the axis of the helical thread measured on the helical thread between. 根据本发明的术语"驱动套管"是指其橫截面基本为圆形的任何基本为管形的元件,该元件可释放地连接到该剂量标度套管上。 According to the present invention, the term "drive sleeve" refers to the cross-section of substantially any substantially round tubular element, the element can be releasably connected to the dose dial sleeve. 在一优选实施例中,该驱动套管还与活塞杆相接合。 In a preferred embodiment, the drive sleeve further engaged with the piston rod. 在本发明的一更具体的实施例中,该驱动套管在第一端具有第一和第二凸缘,并在该第一和第二凸缘之间具有中间螺旋螺紋,从而使一螺母设置在该第一和第二凸缘之间并通过花键装置连接到该壳体上。 In a more specific embodiment of the present invention, the drive sleeve having a first end in a first and a second flange, and between the first and second flanges with an intermediate helical thread, so that a nut disposed between the first and second flange and connected to the housing by spline means. 任选地,可在螺母的第二表面上设置第一径向止动件,并在第二凸缘的第一表面上设置第二径向止动件。 Optionally, a first radial stop member disposed on the second surface of the nut and a second radial stop member disposed on the first surface of the second flange. 根据本发明的术语"可释放地连接"优选地是指本发明的机构或装置的两个元件例如通过离合器可逆地相互连接,这使得可以相接合和脱离接合。 According to the present invention, the term "releasably attached" preferably refers to two elements mechanism or device of the present invention, for example, connected to each other through a clutch reversible, which makes it possible to engage and disengage from. 根据本发明的术语"活塞杆"是指适于穿过该壳体/在该壳体内操作的元件,其设计成用于穿过该给药装置/在该给药装置内传递轴向运动,优选地从驱动套管传递到该活塞,以便排出/分配可注射的药品。 According to the present invention, the term "rod" is meant that the housing / device within the housing adapted to operate through, which is designed to be used through the administering device / transfer axial movement within the delivery device, preferably transmitted from the drive sleeve to the piston, so that the discharge / dispensing injectable drugs. 所述活塞杆可以是柔性的,也可以不是柔性的。 The piston rod may be flexible or may not be flexible. 它可以是简单的杆、导向螺杆、齿条齿轮系统、蜗轮传动系统或类似物。 It may be a simple rod, a lead screw, rack and pinion system, a worm gear transmission or the like. "活塞杆"还指其横截面为圆形或非圆形的元件。 "Rod" also refers to a circular cross-section or non-circular member. 该活塞杆可由本领域内的技术人员已知的任何合适的材料制成。 The rod may be known to those skilled in the art of any suitable material. 在一优选实施例中,活塞杆包括至少一个、多个(优选地两个)外部和/或内部螺旋螺紋。 In a preferred embodiment, the piston rod comprises at least one of a plurality (preferably two) external and / or internal helical threads. 在根据本发明的活塞杆的另一优选实施例中,第一螺旋螺紋位于所述活塞杆的第一端,且第二螺旋螺紋位于所述活塞杆的第二端,其中所述螺紋的设置相同或优选地相反。 In another preferred embodiment the piston rod of the present invention, a first helical thread is located in a first end of said piston rod, and a second helical thread is located in the second end of the piston rod, wherein the thread is provided preferably the same or opposite. 在另一优选实施例中,本发明的活塞杆在第一和第二端包括导程相同的螺紋。 In another preferred embodiment, the piston rod of the present invention, the same threads in the first and second end including lead. 在本发明的另一优选实施例中,活塞杆的第一螺旋螺紋的导程大于第二螺旋螺紋的导程。 In another preferred embodiment of the present invention, the piston rod of the first helical thread leads is greater than the second helical thread lead. 更优选地,所述第一和第二螺旋螺紋的螺紋导程的比率是1:1.01到1:20,甚至更优选地是1:1.1到1:10。 More preferably, the first and second helical thread thread turn ratio is 1: 1.01 to 1:20, even more preferably from 1: 1.1 to 1:10. 优选地,所述螺故之一设计成与该驱动套管相接合。 Preferably, it is one of the screw is designed to engage with the drive sleeve. 可选择地,在本发明的活塞杆的另一优选实施例中,活塞杆设计成任选地通过轴颈轴承附装一齿轮,其中所述齿轮设计成与该驱动套管的螺紋以及一齿条的齿相啮合,其中所述齿条固定在该壳体上。 Alternatively, in another preferred embodiment of the present invention the piston rod, the piston rod is designed to be optionally fitted journal bearing is attached via a gear, wherein said gear is designed to drive the threaded sleeve, and a tooth engagement of the teeth, wherein the rack is fixed to the housing. 根据本发明的术语"第一端,,是指近端。该装置或该装置的元件的近端是指距离该装置的分配端最近的端部。根据本发明的术语"第二端"是指远端。该装置或该装置的元件的远端是指距离该装置的分配端最远的端部。根据本发明的术语"离合器装置"是指任何这样的装置:该装置使该剂量标度套管和该驱动套管可释放地连接,并且该装置设计成允许在该剂量标度套管和该驱动套管联接时该剂量标度套管和该驱动套管相对于该壳体旋转,并在两者脱离联接时,允许该剂量标度套管相对于该壳体旋转, 但不允许该驱动套管相对于该壳体旋转,并允许该驱动套管轴向运动。优选地,该离合器装置将驱动套管可释放地连接到壳体。因此,术语"离合器装置"是指为了可逆地锁定两个元件使其不能(相对)旋转而接合的任何离合器,例如通过使用轴向力以使一组表面齿(锯齿、犬齿、冠齿)或任何其它合适的摩擦面相接合。在本发明的一更具体的实施例中,离合器装置的第二端具有多个适于与剂量标度套管的第二端相接合的犬齿。在一可选择的实施例中,本发明的离合器装置是锁紧弹簧,其可例如通过剂量标度按钮在松弛的第一位置和变形的第二位置之间操作,在该第一位置该剂量标度套管被锁定成与该驱动套管一起旋转,在该第二位置该剂量标度套管被锁定成与该壳体一起旋转。在本发明的又一实施例中,驱动机构还包括任选地i殳置在该离合器装置和设置在该壳体上的花键装置之间的响声器装置(clicker means )。任选地,该响声器装置包括一套管,该套管在第一端具有螺旋形延伸的臂,在该臂的自由端具有一带齿构件,并在第二端具有多个沿圓周定向的锯齿,该锯齿适于接合设置在该离合器装置上的对应的多个沿圆周的锯齿。可选择地,该响声器装置包括一套管,该套管在第一端具有至少一个螺旋形延伸的臂和至少一个弹簧件,在该臂的自由端具有一带齿构件,并在第二端具有多个沿圆周定向的锯齿,该锯齿适于接合设置在该离合器装置上的对应的多个沿圆周定向的锯齿。在本发明的驱动机构的另一实施例中,该驱动机构具有第一止动装置, 该止动装置的形式优选地为位于剂量标度套管上的外部凸缘,并适于接合与该壳体相关联的限制装置,该限制装置的形式优选地为位于壳体内的内部凸缘,以限制可用标度设定的最大剂量。在本发明的驱动机构的又一实9施例中,该驱动机构还具有第二止动装置,该止动装置的形式优选地为位于驱动套管上的外部凸缘,并适于接合限制装置,该限制装置的形式优选地为限制螺母,该螺母键接到该壳体上并安装成用于在该驱动套管的一外部带螺紋部分上3走转,以4见定行程的终止点(an end oflife stop )。 According to the present invention, the term "first end ,, refers to the proximal end of the proximal end of the device or component of the device means that the dispensing end of the device from the end of the most recent. According to the present invention, the term" second end "is refers to the distal end of the distal end of the device or component of the device shall mean the end from the dispensing end of the device in accordance with the terms of the present invention, the farthest of "clutch means" refers to any such device: the device so that the standard dose of the sleeve and the drive sleeve releasably connected, and the device is designed to allow the dose dial sleeve and the drive sleeve when the dose dial coupling sleeve and the drive sleeve with respect to the housing rotation and when two out of the coupling, allowing the dose dial sleeve with respect to the rotating housing, but does not allow the drive sleeve relative to the housing to rotate and allows axial movement of the drive sleeve. Preferably, The clutch means for releasably connecting the drive sleeve to the housing. Thus, the term "clutch means" is means for reversibly locking two elements so that it can not be (relatively) any clutch engaging rotation, e.g., by use of axial forces for a group of surfaces of teeth (serrations, canine, crown teeth) or any other suitable frictional surface engagement. In a more specific embodiment of the present invention, the second end of the clutch device having a plurality of adapted dose scale The second end of the sleeve engaging canines. In an alternative embodiment, the clutch device of the present invention is a locking spring, which can be for example the first position by the dose dial buttons and a second position in relaxation deformation between operations in the first position of the dose dial sleeve is locked to rotate together with the drive sleeve, the second position of the dose dial sleeve is locked to rotate together with the housing. In the present invention, yet another embodiment, the drive mechanism further comprises i Shu optionally placed between the clutch means and disposed on the housing spline device sound device (clicker means). Optionally, the sound device means including a sleeve, the sleeve having a first end helically extending arm, at the free end of the arm having a toothed member, and at a second end having a plurality of circumferentially directed saw teeth, adapted to engage the serrated clutch means provided on the corresponding plurality of circumferentially saw teeth. Alternatively, the sound device comprises a sleeve, the sleeve having a first end of the at least one helically extending arm and at least one spring member, the free end of the arm having a toothed member, and at a second end having a plurality of circumferentially directed saw teeth, which is adapted to sawtooth plurality of circumferentially oriented engaging corresponding serrations provided on the clutch means. In the present invention, Another embodiment of the drive mechanism, the drive mechanism having a first stop means, the stop means in the form of an external flange is preferably located on the dose dial sleeve and adapted to engage with the associated housing limiting device associated form of the restriction device is preferably located inside the flange housing, to limit the maximum dose available scale set in the drive mechanism of the present invention, another solid 9 embodiment, the drive mechanism also has a second stop means, the stop means in the form of drive is preferably located on the outside of the flange sleeve, and adapted to engage limiting means, preferably in the form of the limiting means for limiting a nut bonded and install the casing to go for 3 in a turn on the threaded portion of the outer sleeve of the drive belt to see fixed termination point 4 stroke (an end oflife stop). 本发明的第二个方面是提供一种用于给药装置的组件,该组件包括根据本发明的驱动机构。 A second aspect of the present invention is to provide components for a delivery device, the assembly includes a drive mechanism according to the present invention. 本发明的第三个方面提供了一种给药装置,该给药装置包括根据本发明的驱动机构或组件。 A third aspect of the present invention there is provided a drug delivery device, which comprises administering device according to the present invention, the drive mechanism or the assembly. 本发明的第四个方面是提供一种组装给药装置的方法,该方法包才舌提供根据本发明的驱动机构或组件的步骤。 A fourth aspect of the present invention is to provide a method of assembling a drug delivery device, the method according to the steps provided only tongue drive mechanism or assembly of the present invention. 本发明的第五个方面是根据本发明的给药装置的应用,其用于分配药品,优选地分配包含选自胰岛素、生长激素、低分子量肝素以及它们的类似物和衍生物的活性化合物的药物配方(例如溶液、悬浮液等)。 A fifth aspect of the present invention is based on the application administering device of the present invention for dispensing medicines containing the active compound is preferably selected distribution insulin, growth hormone, low molecular weight heparins and their analogues and derivatives of pharmaceutical formulation (e.g. solution, suspension, etc.). 附图说明下面将结合一优选实施例并参照附图来更详细说明本发明,但这不作为任何限制,在该附图中:图1示出处于药筒装满的第一位置的根据本发明的给药装置的第一实施例的剖^L图;图2示出处于最大的笫一剂量被设定的第二位置的图1的给药装置的剖一见图;图3示出处于最大的第一剂量被分配的第三位置的图1的给药装置的剖视图;图4示出处于最终的剂量被设定的第四位置的图1的给药装置的剖视图;图5示出处于最终的剂量被分配的第五位置的图1的给药装置的剖视图;图6示出图1的给药装置的第一细部的剖开立体图;图7示出图1的给药装置的第二细部的局部剖开立体图; 图8示出图1的给药装置的第三细部的局部剖开立体图; 图9示出增加用标度设定的剂量期间图1中所示的给药装置的部件的相对运动;图IO示出减小用标度设定剂量期间图1中所示的给药装置的部件的相对运动;图n示出在分配剂量期间图1中所示的给药装置的部件的相对运动; 图12示出处于最大第一剂量^皮设定的第二位置的图l的给药装置的局部剖开立体图;图13示出处于最终剂量被设定的第四位置的图1的给药装置的局部剖开立体图;图14示出处于第一、第三或第五位置之一的图1的给药装置的局部剖可立体图;图15示出图1的给药装置的主壳体的第一部分的剖开立体图; 图16示出图1的给药装置的主壳体的第二部分的剖开立体图; 图17示出处于药筒装满的第一位置的根据本发明的驱动机构的第二实施例的剖视图;图18示出处于药筒装满的第一位置的根据本发明的给药装置的第三实施例的侧剖^f见图;图19示出处于最大第一剂量被设定的第二位置的图18的给药装置的侧剖一见图;图20示出处于最大第一剂量被分配的第三位置的图18的给药装置的侧剖视图;图21示出处于最终的剂量被^:定的第四位置的图18的给药装置的侧剖视图;图22示出处于最终的剂量被分配的第五位置的图18的给药装置的侧剖视图;图23以放大比例示出图18的给药装置的一段;以及图24以放大比例示出图18的给药装置的另一段。 BRIEF DESCRIPTION connection with a preferred embodiment and with reference to the accompanying drawings of the present invention is described in more detail, but without any limitation, in the accompanying drawings in which: Figure 1 shows a first position of the filled cartridge according to the present a first cross-sectional embodiment of the invention means administering ^ L; Figure 2 shows a drug delivery device in the largest Zi is set to the second position, the dose of a cross-sectional diagram of Figure 1; Figure 3 shows a in the largest cross-sectional view of a first dose administering device is assigned a third position of FIG. 1; FIG. 4 shows the final dose has been set in the fourth position of the cross-sectional view of the administering device of FIG. 1; FIG. 5 shows cross-sectional view of the final dose administering device is assigned a fifth position in Figure 1 a; Fig. 6 shows the drug delivery device of Figure 1 cut-away perspective view of a first detail; FIG. 7 shows an administering device of FIG. a second partial cutaway perspective view of a detail; Figure 8 shows a partial administering device of Figure 1 cut-away perspective view of a third detail; Figure 9 shows an increase to a dose map shown in use during the setting of the scale relatively moving parts of the dosing device; Figure IO shows a decrease of the relative movement of parts during delivery device shown in FIG. 1 with the scale set dose; n shown in FIG illustrated in Figure 1 during dispensing of a dose relatively moving parts of the administering device; FIG. 12 shows a maximum at a first dose of transdermal ^ to set a second position of FIG. l administering device partially cut away perspective view; FIG. 13 shows the dose is set in the final a partial cutaway perspective view of a fourth position of administering device 1; Figure 14 shows a perspective view in partial cross-section can be administered in view of the first apparatus, one third or fifth position 1; FIG. 15 shows a diagram a first portion of the drug delivery device of the cut-away perspective view of the main housing; FIG. 16 shows a cut-away perspective view of a second portion of the main housing of the drug delivery device of FIG. 1; FIG. 17 shows a cartridge loaded in the a first position a sectional view of an embodiment of the present invention, the driving mechanism according to a second; Figure 18 shows the cartridge in a first position of the full cross-sectional side ^ f see a third embodiment according to the administering device of the present invention. ; Figure 19 shows a first side in a second position of the maximum dose of the drug delivery device is set in a cross-sectional diagram of Figure 18; Figure 20 shows a maximum at a first dose of the assigned third position 18 The cross-sectional side view of the drug delivery device; FIG. 21 shows the dose is in the final ^: a cross-sectional side view of a fourth predetermined position of the administering device in FIG 18; FIG. 22 shows in the final dose dispensed position fifty administering a sectional side view of the apparatus of FIG. 18; FIG. 23 is an enlarged scale section of administering device shown in FIG. 18; and FIG. 24 in an enlarged scale showing another section of the drug delivery device 18 of FIG.

具体实施方式示例1 DETAILED DESCRIPTION Example 1

首先参照图1-5,其中示出处于多个位置的根据本发明的给药装置。 Referring first to Figures 1-5, there is shown apparatus according to the present invention is administered in a plurality of positions. 该给药装置包括一壳体,该壳体具有第一药筒保持装置2,和第二主(外部)壳体部件4。 The administering apparatus comprises a housing having a first cartridge retaining means 2 and a second main (exterior) housing part 4. 药筒保持装置2的第一端和主壳体4的第二端通过 A first end of the cartridge retaining means 2 and the second end of the main housing 4 through

保持部件6固定在一起。 Holding member 6 is fixed together. 在所示的实施例中,药筒保持装置2紧固在主壳 In the illustrated embodiment, the cartridge retaining means 2 is fastened to the main housing

体4的笫二端内。 The inner Zi two ends 4.

在药筒保持装置2内设置有药筒8,从该药筒可分配多种剂量的药品。 In the cartridge retaining means 2 is provided with the cartridge 8, the cartridge can be assigned a variety of drug doses of drugs. 活塞10被保持在药筒8的第一端内。 Piston 10 is held within the first end 8 of the cartridge.

活动盖12被可释;^丈地保持在药筒保持装置2的第二端上。 Movable cover 12 is releasably; ^ husband held on the second end of the cartridge retaining means 2. 在使用时, 活动盖12可被使用者用合适的针组件(未示出)代替。 In use, the movable cover 12 can be user replaced by a suitable needle assembly (not shown). 可更换的盖14用于覆盖从主壳体4延伸的药筒保持装置2。 Replaceable cover 14 for covering the holding extending from the main housing 4 cartridge device 2. 优选地,可更换的盖H的外部尺寸接近或等于主壳体4的外部尺寸,以便在该可更换的盖14处于覆盖药筒保持装置2的位置时进行整体压印。 Preferably, the replaceable cap H outer dimension close to or equal to the outer dimensions of the main housing 4, so that the cover 14 can be replaced in whole covering the cartridge retaining means 2 platen position.

在所示的实施例中, 一插入件16设置在主壳体4的第一端处。 In the embodiment shown, an insert 16 is disposed at a first end of the main housing 4. 插入件16被固定,从而不能进行旋转或纵向运动。 Insert member 16 is fixed, and thus can not be rotated or longitudinal movement. 插入件16具有一从中穿过的带螺紋的圆形开口18。 A threaded insert member 16 having a circular opening therethrough of 18. 可选择地,该插入件可与主壳体4一体地形成,并且形式为具有内部螺紋的沿径向向内定向的凸缘。 Alternatively, the insert may be integrally with the main housing 4 is formed, and in the form of an internal thread having a radially inwardly directed flange.

第一螺紋19从活塞杆20的第一端延伸。 The first thread 19 extends from the first end of the piston rod 20. 活塞杆20的截面通常为圆形。 Cross-section of the piston rod 20 is generally circular. 活塞杆20的第一端延伸通过插入件16中的带螺紋的开口18。 A first end of the piston rod 20 extends through the insert 16 in the threaded opening 18. 压脚22位于活塞杆20的第一端上。 The presser foot 22 is located on the first end 20 of the piston rod. 压脚22设置成紧靠药筒的活塞10的第二端。 The presser foot 22 is arranged close to a second end of the piston cartridge 10. 第二螺紋24从活塞杆20的第二端延伸。 The second thread 24 extends from the second end of the piston rod 20. 在所示的实施例中,第二螺紋24 包括多个部分螺紋而不是一个全螺紋。 In the illustrated embodiment, the second threaded portion 24 includes a plurality of threads rather than a full thread. 所示的实施例较容易制造,并且有助于降低在分配药品时由使用者致动该装置所需的全部力。 Embodiment shown relatively easy to manufacture and helps reduce the allocation of the drug by a user actuated force required to all the devices.

第一螺紋19和第二螺紋24相反地设置。 The first thread 19 and second thread 24 disposed opposite. 活塞杆20的第二端具有接纳凹槽26。 The second end 20 of the piston rod has a receiving recess 26.

12驱动套管30围绕活塞杆20延伸。 12 of the drive sleeve 30 extends about the piston rod 20. 驱动套管30通常为圆筒形。 Drive sleeve 30 is generally cylindrical. 驱动套管30在第一端具有沿径向延伸的第一凸缘32。 Drive sleeve 30 at a first end of the first flange 32 having a radially extending. 沿径向延伸的第二凸纟彖34 沿驱动套管30与第一凸缘32相隔一定距离设置。 A second radially extending projection 34 Si Tuan drive sleeve 30 along the first flange 32 disposed at a distance. 中间螺乡文36设置在驱动套管30的外部部分上并在第一凸缘32和第二凸缘34之间延伸。 Lo Wen township middle 36 set to extend in the outer portion of the drive sleeve 30 between the first flange 32 and second flange 34. 螺旋形凹槽(螺紋)38沿驱动套管30的内表面延伸。 Helical groove (thread) 38 along the inner surface of the drive sleeve 30 extends. 活塞杆20的第二螺紋24适于在该螺旋形凹槽38内行进。 Piston rod 20 of the second thread 24 is adapted to travel in the helical groove 38.

第一凸缘32的第一端适于与插入件16的第二侧相适应。 The second side of the first flange of the first end 32 of the insert member 16 is adapted to fit. 螺母40位于驱动套管30和主壳体2之间,并设置在第一凸缘32和第二凸缘34之间。 Nut 40 is located between the two drive sleeve 30 and the main housing, and is disposed between the first flange 32 and second flange 34. 在所示的实施例中,螺母40是对开螺母。 In the illustrated embodiment, the nut 40 is a half-nut. 这样有助于该装置的装配。 This will help assembly of the apparatus. 螺母40的内螺乡丈与中间螺紋36相匹配。 Township husband nut screw thread 40 and the middle 36 matches. 螺母40的外表面与主壳体4的内表面通过花键42连接在一起(图10、 11、 15和16),以防止在螺母40和主壳体4之间发生相对旋转,同时允许在它们之间进行相对的纵向运动。 The inner surface of the outer surface of the nut 40 and 42 of the main housing 4 connected together by a spline (10, 11, 15 and 16), to prevent relative rotation between the nut 40 and the main housing 4, while allowing relative longitudinal movement between them.

在驱动套管30的第二端和设置在驱动套管30的第二端处的延伸部38 之间形成肩部37。 In between the second end of the extending portion 30 of the drive sleeve 30. The drive sleeve 38 is formed a second end and a shoulder 37 provided. 与驱动套管30的其余部分相比,延伸部38的内径和外径均减小。 Compared with the rest of the drive sleeve 30, the extension 38 inside and outside diameters are reduced. 延伸部38的第二端具有一沿径向向外定向的凸缘39。 Extending a second end portion 38 has a radially outwardly directed flange 39.

响声器50和离合器60在驱动套管30和剂量标度套管70 (下文将说明)之间围绕驱动套管30设置。 Sound 50 and a clutch 60 in the drive sleeve 30 and dose dial sleeve 70 (described later) between the sleeve 30 is disposed about the drive.

响声器50位于靠近驱动套管30的第二凸缘34处。 Sound 50 is located close to the drive sleeve 30. The second flange 34. 响声器50通常为圆筒形,并且在第一端具有柔性的螺旋形延伸的臂52 (图6)。 Sound 50 is generally cylindrical, and has a flexible helically extending arm 52 (FIG. 6) at the first end. 臂52的一自由端具有沿径向定向的带齿构件54。 A free end of the arm having a toothed member 52 radially oriented 54. 响声器50的第二端具有多个沿圆周定向的锯齿56 (图7)。 Sound of the second end 50 having a plurality of circumferentially directed saw teeth 56 (FIG. 7). 每个锯齿包括一纵向定向表面和一倾斜表面。 Each sawtooth comprises a longitudinally directed surface and an inclined surface.

在一可选择的实施例(未示出)中,响声器还包括至少一个弹簧件。 In an alternative embodiment (not shown), the sound further comprises at least one spring member. 该至少一个弹簧件有助于在分配后使离合器60复位。 The at least one spring member to help in the distribution of the clutch 60 is reset.

离合器60位于靠近驱动套管30的第二端处。 Clutch 60 is located close to a second end of the drive sleeve 30. 离合器60大致为圆筒形, 并且在其第一端具有多个沿圓周定向的锯齿66 (图7)。 Clutch 60 is generally cylindrical and has a plurality of circumferentially directed saw teeth 66 (FIG. 7) at its first end. 每个锯齿包括一纵向定向表面和一倾斜表面。 Each sawtooth comprises a longitudinally directed surface and an inclined surface. 朝向离合器60的第二端64设置有沿径向向内定向的凸缘62。 Clutch 60 toward the second end 64 is provided with a radially inwardly directed flange 62. 离合器60的凸缘62位于驱动套管30的肩部37和延伸部38的沿径向向外定向的凸缘39之间。 The flange 60 of the flange 62 of the clutch driving shoulder 30 of the sleeve 37 and the radially extending portion 38, 39 between the outwardly directed. 离合器60的第二端具有多个犬齿65 (图8 )。 The second end of the clutch 60 has a plurality of canine teeth 65 (FIG. 8). 离合器60通过花键(未示出)连接到该驱动套管30上,以防止在离合器60和驱动套管30之间发生相对4t转。 Clutch 60 is connected by a spline (not shown) on the drive sleeve 30 to prevent between the clutch 60 and the drive sleeve 30 occur relatively 4t rpm.

在所示的实施例中,响声器50和离合器60均延伸驱动套管30的长度的大约一半。 In the illustrated embodiment, the sound device 50 and the clutch 60 each extend approximately half the length of the drive sleeve 30.. 但是,应理解关于这些部件的相对长度的其它设置也是可以的。 However, it should be understood that other settings regarding the relative lengths of these parts are also possible.

响声器50和离合器60如图7中所示相接合。 And a clutch 60 shown in Figure 7 sound 50 engage.

剂量标度套管70设置在响声器50和离合器60的外部,并从主壳体4 沿径向向内。 The dose dial sleeve 70 is provided in the external sound 50 and a clutch 60, and inwardly from the main housing 4 along the radial direction. 螺旋形凹槽74围绕剂量标度套管70的外表面设置。 Helical groove 74 around the outer surface of the dose dial sleeve 70 is provided.

主壳体4具有一窗口44,通过该窗口可看到剂量标度套管的外表面的一部分。 The main housing 4 has a window 44, through the window you can see a portion of the dose dial sleeve outer surface. 主壳体4还具有螺旋形肋部(螺紋)46,其适于安置在剂量标度套管70的外表面上的螺旋形凹槽(螺紋)74内。 Main housing 4 also has helical rib (thread) 46, adapted to placed in the outer surface of the dose dial sleeve 70. The helical groove (thread) 74 within. 螺旋形肋部46延伸形成主壳体4的内表面上的单个曲线(single sweep )。 Spiral rib single curve (single sweep) on the inner surface of the housing 46 extends 4 form. 第一止动件100设置在花键42和螺旋形肋部46之间(图15 )。 The first stopper 100 provided in the spline between 42 and spiral rib 46 (Figure 15). 第二止动件102由围绕主壳体4 中的窗口44的框架形成,该第二止动件设置成与第一止动件100成180。 The second stopper 102 is formed by a frame around the window in the main housing 44 4, the second stopper member provided with the first stopper 100 to 180. 的角度(图16)。 Angle (FIG. 16).

方便地,可被用标度设定的剂量的可视标记例如参考数字(未示出) 设置在剂量标度套管70的外表面上。 Conveniently, the scale can be used to set the amount of visual indicia such as reference numeral (not shown) provided at the dose dial sleeve 70 outer surface. 窗口44方便地仅允许看到当前被设定的剂量的可视标记。 Window 44 conveniently only allows to see the currently set dose of visual marker.

剂量标度套管70的第二端具有形式为多个径向延伸件75的向内定向的凸缘。 Dose dial sleeve 70 form a second end having a plurality of radially inwardly directed flange extending member 75. 剂量标度夹持件76设置成围绕剂量标度套管70的第二端的外表面。 Dose scale holding member 76 is provided so as to surround the dose dial sleeve 70 the outer surface of the second end. 剂量标度夹持件76的外径优选地等于主壳体4的外径。 Dose scaling the outer diameter of the clamping member 76 is preferably equal to the diameter of the main housing 4. 剂量标度夹持件76固定在剂量标度套管70上以防止在它们之间发生相对运动。 Dose scale holding member 76 is fixed on the dose dial sleeve 70 to prevent relative movement therebetween. 剂量标度夹持件76具有中心开口78。 Dose scale holding member 76 has a central opening 78. 位于剂量标度夹持件76的第二端内的环形凹槽80围绕开口78延伸。 The second end of the annular groove is located dosage scale 80 of the clamping member 76 extends around the opening 78.

截面大致为"T"形的按钮82设置在该装置的第二端处。 Substantially sectional "T" shaped button 82 disposed at the second end of the apparatus. 按钮82的杆部84可延伸穿过剂量标度夹持件76中的开口78,并穿过驱动套管30 的延伸部38的内径并进入活塞杆20的接纳凹槽26内。 The stem portion 82 of the button 84 may extend through the dose scale holder 76 in the opening 78, and passes through the inner diameter of the drive sleeve 38 extending portion 30 and into the receiving recess 26 of the piston rod 20. 杆部84被保持成可在驱动套管30内进行受限的轴向运动,并且不能相对于该驱动套管旋 Shank 84 is held axially movable drive sleeve 30 is limited in, and can not with respect to the rotary drive sleeve

转。 Turn. 按钮82的头部85大致为圆形。 The head 82 of the button 85 is generally circular. 围缘86从头部85的周向垂下。 Peripheral edge 86 from the head 85 in the circumferential direction hanging. 围缘86适于安置在剂量标度夹持件76的环形凹槽80内。 Peripheral edge 86 is adapted to reside in the dose dial annular groove 76 of the holding member 80.

下面将说明根据本发明的给药装置的操作。 Administering device will be described operation of the present invention. 在图9、 lO和ll中,箭头A、 B、 C、 D、 E、 F和G分别代表按钮82、剂量标度夹持件76、剂量标度套管70、驱动套管30、离合器60、响声器50和螺母40的运动。 In Figure 9, lO and ll, the arrow A, B, C, D, E, F and G represent the button 82, the dose dial holding member 76, the dose dial sleeve 70, the drive sleeve 30, the clutch 60 , sound 50 and nut 40 movement.

为了用标度设定一个剂量(图9 ),使用者旋转剂量标度夹持件76 (箭头B)。 In order to set a dose (Figure 9) with a scale, the user rotates the dose dial holding member 76 (arrow B). 通过响声器50和离合器60相接合,驱动套管30、响声器50、离合器60和剂量标度套管70与剂量标度夹持件76 —起旋转。 By the sound of 50 and clutch 60 is engaged, the drive sleeve 30, a sound 50, clutch 60 and the dose dial sleeve 70 and dose dial holding member 76-- starting rotation.

可通过响声器50和离合器60提供被设定的剂量的可听见的和可触知的反馈。 It can be set dose provided by a sound 50 and a clutch 60 audible and tactile feedback. 通过锯齿56、 66在响声器50和离合器60之间传递力矩。 By sawtooth 56, 50, 66 between the sound and the clutch 60 transmit torque. 柔性臂52发生变形并在花键42上方拖动带齿构件54以产生卡嗒声。 Flexible arms 52 and 42 are deformed drag over the spline toothed member 54 to produce a clicking sound. 优选地,花键42设置成每个卡嗒声对应于一个常用的单位剂量或类似物。 Preferably, the splines 42 are provided to each of clicks corresponds to a conventional unit dose, or the like.

剂量标度套管70上的螺旋形凹槽74和驱动套管30中的螺旋形凹槽38具有相同的导程。 Dose dial sleeve 74 and the helical groove 30 in the drive sleeve 70 on the helical groove 38 have the same lead. 这使得剂量标度套管70(箭头C)可从主壳体4伸出, 并且驱动套管30 (箭头D)以同样的速度沿活塞杆20爬升。 This allows the dose dial sleeve 70 (arrow C) to extend from the main housing 4 and the drive sleeve 30 (arrow D) along with the piston rod 20 at the same rate of climb. 在行程的边界处,剂量标度套管70上的径向止动件104 (图12 )接合设置在主壳体4 上的第一止动件IOO或第二止动件102,以阻止进一步移动。 At the boundary of the trip, the dose dial sleeve 70 on the radial stop 104 (Figure 12) engages is provided on the main housing of the movable member 4 IOO first stop or the second stop 102, in order to prevent further Mobile.

由于活塞杆20上的被放松的(overhauled )螺紋与被旋紧的(driven ) 螺紋的方向相反,因此可防止活塞杆20旋转。 Because the piston rod is relaxed (overhauled) with thread 20 (driven) direction opposite thread is tightened, thereby preventing rotation of the piston rod 20.

键接到主壳体4的螺母40由于驱动套管30的旋转(箭头D)而沿中间螺紋36前进。 Bonded to the nut 40 of the main housing 4 due to the rotation of the drive sleeve 30 (arrow D) along the intermediate thread 36 forward. 当到达最终的剂量被分配的位置(图4、 5和13)时,在螺母40的第二表面上形成的径向止动件106紧靠驱动套管30的第二凸缘34的第一表面上的径向止动件108,以便防止螺母40和驱动套管30进一步旋转。 When it reaches the position (Fig. 4, 5 and 13) the final dose dispensed, a second radial surface 40 on the nut of the stopper member 106 formed on the drive sleeve 30 abuts the second flange 34 of the first radial stop surface 108 to prevent further rotation of the nut 40 and the drive sleeve 30.

在一可选择的实施例(未示出)中,螺母40的第一表面具有用于紧靠设置在第一凸缘32的第二表面上的径向止动件的径向止动件。 In an alternative embodiment (not shown), the first surface of the nut 40 has a radial stop member for radially disposed against the second surface of the first flange 32 of the stopper. 这样有助于在装配该给药装置期间使螺母40位于药筒装满的位置。 This helps during assembly of the drug delivery device is located in the cartridge nut 40 positions filled. 如果使用者无意间用标度设定的剂量超过所需剂量,则该给药装置允许减小该剂量的设定而无需从药筒分配药品(图10)。 If a user inadvertently set by the scale doses greater than the required dose, the drug delivery device allows for a reduction of the dose setting without drugs dispensed from the cartridge (Figure 10). 使剂量标度夹持件 So that the dose dial holding member

76反向旋转(箭头B)。 76 reverse rotation (arrow B). 这使该系统相反地起作用。 This makes the system works contrary. 柔性臂52防止响声器50旋转。 Flexible arm 52 to prevent rotation of the sound 50. 通过离合器60传递的力矩使锯齿56、 66彼此跨过,从而产生对应于减小设定的剂量的卡嗒声。 Torque transmitted through the clutch 60 sawtooth 56, 66 cross each other, resulting in the set corresponding to the reduced amount of clicks. 优选地,锯齿56、 66设置成每个锯齿的圓周长度对应于一个单位剂量。 Preferably, serrations 56, 66 arranged in the circumferential length of each sawtooth corresponds to a unit dose.

当已用标度设定所需剂量时,使用者可以随后通过按下按钮82来分配该剂量(图11)。 When the desired dose has been set by the scale, the user can then by assigning the dose (Figure 11) Press button 82. 这使离合器60相对于剂量标度套管70沿轴向移动,从而使犬齿65脱离接合。 This allows clutch 60 with respect to the dose dial sleeve 70 moves axially, so that 65 out of engagement canine. 但是,离合器60保持键接到驱动套管30,从而与其一起旋转。 However, the clutch 60 remains bonded to the drive sleeve 30, so as to rotate together therewith. 剂量标度套管70和相关联的剂量标度夹持件76此时可自由旋转(由位于螺旋形凹槽74中的螺旋形肋部46引导)。 The dose dial sleeve 70 and dose dial holding member 76 associated with this case can rotate freely (by the spiral groove 74 located in the helical guide ribs 46).

该轴向运动使响声器50的柔性臂52变形,以确保在分配期间锯齿56、 66不能被放松。 The axial movement of the flexible arm 52 so that sound is 50 deformed to ensure sawtooth 56, 66 can not be relaxed during the assignment. 这防止了驱动套管30相对于主壳体4旋转,但是驱动套管30仍可相对于主壳体4自由地轴向移动。 This prevents the drive sleeve 30 with respect to the main housing 4 is rotated, but the drive sleeve 30 with respect to the main housing 4 is still free to move axially. 此变形随后可用于沿驱动套管30推回响声器50和离合器60,以便当从按钮82去掉压力时恢复离合器60和剂量标度套管70之间的连接。 This deformation can then be used to push back along the drive sleeve 30 sound 50 and the clutch 60 so that when the recovery of the clutch 60 and the dose dial button 82 when pressure is removed from the casing 70 between the connection.

驱动套管30的纵向轴向运动使活塞杆20穿过插入件16中的开口18 而旋转,从而使活塞10在药筒8中前进。 Longitudinal axial movement of the drive sleeve 30 causes the piston rod 20 is inserted through the opening 18 in the member 16 is rotated, so that the piston 10 in the cartridge 8 forward. 一旦已分配所设定的剂量,就可通过使从剂量标度夹持件76延伸的多个构件110 (图14)与在主壳体4 中形成的对应的多个止动件112 (图15和16)相接触,来防止剂量标度套管70进一步旋转。 Once the set dose has been allocated, by making possible a corresponding plurality of member 110 from a plurality (FIG. 14) the dose scale holding member 76 extending in the main housing 4 and the stopper 112 is formed (FIG. 15 and 16) in contact to the dose dial sleeve 70 to prevent further rotation. 在所示的实施例中,构件110从剂量标度夹持件76沿轴向延伸,并具有一倾斜的端面。 In the illustrated embodiment, the member 110 from the dose scale 76 extending axially along the holding member, and having an inclined end surface. 零剂量位置由构件110的沿轴向延伸的边缘之一紧靠对应的止动件112来确定。 One edge of the zero dosage position by the axially extending member 110 abuts against the stopper member 112 corresponding to the determined.

示例2 Example 2

在本发明的另一个实施例中(图17),可以看到包括第二主壳体4, 的驱动机构,该壳体具有第一端部和第二端部。 In another embodiment of the present invention (FIG. 17), you can see the second main housing 4 comprises, a drive mechanism, the housing having a first end and a second end portion. 容纳药品的药筒可安装在该第二主壳体4,的第一端部上,并被任何合适的装置保持。 Receiving the first end portion of the drug cartridge may be mounted in the second main housing 4, and by any suitable holding means. 在所示的实施例中未示出药筒及其保持装置。 In the illustrated embodiment (not shown) and the cartridge holder. 该药筒可包含多种剂量的药品,并且通常还包含一个可移动的活塞。 The cartridge can contain multiple doses of the drug, and usually also includes a movable piston. 该活塞的移动使得药品可从该药筒经由针头(也未示出)排出。 Movement of the piston so that the drug can be via a needle (also not shown) from The cartridge discharge. 在所示的实施例中,在该主壳体4,内设置有插入件16,。 In the embodiment shown, the main housing 4, the insert member 16 is provided with a ,. 该插入件16, 被固定,从而不能相对于第二主壳体4,进行旋转运动和轴向运动。 The insert member 16 is fixed, and thus can not relative to the second main housing 4, rotational movement and axial movement. 插入件16,具有从中穿过的一带螺紋的圆形开口。 Insert member 16, having a threaded circular opening therethrough. 可选择地,该插入件可与第二主壳体4,一体地形成。 Alternatively, the insert with the second main housing 4 is integrally formed. 在第二主壳体4,内还设置有一内部壳体154。 In the second main housing 4, it is also provided with an inner housing 154. 该内部壳体154被固定, 从而不能相对于第二主壳体4,进行旋转运动和轴向运动。 The inner housing 154 is fixed, and thus can not relative to the second main housing 4, rotational movement and axial movement. 内部壳体154具有一贯穿其长度的圆形开口,在该开口中形成多个纵向花键。 The internal housing 154 having a circular opening through its length, a plurality of longitudinal splines formed in the opening. 螺旋螺乡丈150 沿内部壳体154的外圆柱面延伸。 Township 150 feet along the spiral screw inside the outer cylindrical housing 154 extends. 可选择地,该内部壳体可与该第二主壳体4,和/或插入件16,一体地形成。 Alternatively, the inner housing with the second main housing 4 and / or insert member 16 is integrally formed. 第一螺紋19,>人活塞杆20,的第一端部延伸。 The first thread 19,> Human piston rod 20, a first end portion extending. 该活塞杆20,的截面大致为圆形。 Section of the piston rod 20, is substantially circular. 活塞杆20,的第一端部穿过插入件16,中的带螺紋的开口,活塞杆20,的第一螺紋19,与插入件16,的螺纟丈相接合。 The first thread of the piston rod 20, a first end portion through the insertion member 16, the opening of the threaded rod 20, 19, with the insert 16, the screw engagement Si feet. 压脚22,位于活塞杆20,的第一端部上。 The presser foot 22, is located in the piston rod 20, the first end. 压脚22,设置成紧靠药筒活塞(未示出)。 The presser foot 22, is arranged close to the cartridge piston (not shown). 第二螺紋24,从活塞杆20,的第二端部延伸。 The second thread 24, the piston rod 20, a second end portion extending. 第一螺紋19,和第二螺紋24,相反地设置。 The first thread 19, and a second thread 24, on the contrary provided. 驱动套管30,围绕活塞杆20,延伸。 The drive sleeve 30 around the piston rod 20 extends. 驱动套管30,通常为圆筒形。 Drive sleeve 30 is generally cylindrical. 驱动套管30,在第一端部具有第一径向延伸的凸缘32,。 The drive sleeve 30, at a first end portion having a first radially extending flange 32 ,. 沿驱动套管30,与第一凸缘32,相隔一定距离设置有第二径向延伸的凸缘34,。 Along the drive sleeve 30, the first flange 32, there are provided spaced from the second radially extending flange 34 ,. 在驱动套管30,的外部部分上设置有外部螺旋螺紋(未示出),该外部螺紋在第一凸缘32, 和第二凸缘34,之间延伸。 Provided with an external screw thread (not shown) on the drive sleeve 30, the outer portion of the first flange 32, and a second flange 34, extending between the external thread. 一内部螺旋螺紋沿驱动套管30,的内表面延伸。 An internal helical thread along the drive sleeve 30, the inner surface of the extension. 活塞杆20,的第二螺紋24,与驱动套管30,的内部螺旋螺纹相接合。 Piston rod 20, the second thread 24, and the drive sleeve 30, the internal screw thread engagement. 螺母40,位于驱动套管30,和内部壳体154之间,并设置在驱动套管30, 的第一凸缘32,和第二凸缘34,之间。 Nut 40, located between the drive sleeve 30, and the inner casing 154, and 34 disposed between the drive sleeve 30, a first flange 32, and the second flange. 螺母40,可以是"对开螺母"或"全高螺母,,。螺母40,具有与驱动套管30,的外部螺旋螺紋相接合的内部螺紋。 螺母40,的外表面和内部壳体154的内表面通过纵向花键连接在一起,以防止螺母40,和内部壳体154之间发生相对旋转,同时允许它们之间发生相对纵向运动。响声器50,和离合器60,围绕驱动套管30,设置,并位于驱动套管30, 和内部壳体154之间。响声器50,靠近驱动套管30,的笫二凸缘34,设置。响声器50,包括至少一个弹簧元件(未示出)。响声器50,还包括一组设置成朝向该驱动机构的第二端部的具有三角形状的齿(未示出)。当被压缩时,该响声器50,的至少一个弹簧元件在驱动套管30,的凸缘34,和离合器60,之间施加轴向力。 响声器50,的外表面和内部壳体154的内表面通过纵向花键连接在一起,以防止响声器50,和内部壳体154之间发生相对旋转,同时允许它们之间发生相对纵向运动。离合器60,靠近驱动套管30,的第二端部设置。离合器60,大致为圆筒形,并且在其第一端部具有多个围绕圆周设置的三角形状的齿(未示出), 该齿作用在响声器50,的齿上。朝向离合器60,的第二端部设有肩部158。 离合器60,的肩部158设置在内部壳体154和剂量标度夹持件76,(下面将说明)的径向向内的凸缘之间。离合器60,的肩部158具有多个沿该驱动机构的第二端部的方向延伸的犬齿(未示出)。离合器60,通过花键(未示出)连接在驱动套管30,上,以防止离合器60,和驱动套管30,之间发生相对旋转。剂量标度套管70,设置在内部壳体154外部,并从第二主壳体4'沿径向向内。在剂量标度套管70,的内表面上设置有螺旋螺紋。该剂量标度套管70,的螺旋螺紋与内部壳体154的螺旋螺紋150相接合。第二主壳体4,具有一窗口(未示出),通过该窗口可看到剂量标度套管70,的外表面的一部分。方便地,在剂量标度套管70,的外表面上设有可用标度设定的剂量的可视标记例如参考数字(未示出)。方便地,第二主壳体4,的窗口仅允许看到目前被用标度设定的剂量。剂量标度夹持件76,位于朝向该驱动机构的第二端部处。该剂量标度夹持件76,^f皮固定,从而不能相对于该剂量标度套管70,进行旋转运动和轴向运动。剂量标度夹持件76,具有一沿径向向内的凸缘160。剂量标度夹持件76,的沿径向向内的凸缘160具有多个犬齿(未示出),该犬齿沿该驱动机构的笫一端部的方向延伸以紧靠离合器60,的犬齿。 Nut 40, can be "half-nut" or "full-height nut ,, nut 40, with the drive sleeve 30, the outer helical thread engaging the internal thread nut 40, the inner and outer surfaces of the interior of the housing 154 surface connected by longitudinal splines together to prevent relative rotation between the nut 40 and the internal housing 154, while allowing relative longitudinal movement between them. sound 50, and the clutch 60, the sleeve 30 around the drive, set and is located between the drive sleeve 30, and the inner casing 154. sound 50, close to the drive sleeve 30, the undertaking of the second flange 34 is provided. sound 50, comprising at least one spring member (not shown). sound 50, further comprising a set of teeth arranged to have a triangular shape toward the second end portion of the drive mechanism (not shown) when compressed, the sound of 50, at least one spring element in the drive sleeve an outer surface and an inner surface of the inner casing 154 is applied between the 30, the flange 34, and the clutch 60, the axial force sound 50, connected through vertical splines together to prevent sound 50, and the internal shell relative rotation between the body 154, while allowing relative longitudinal movement between them. clutch 60, and close to the drive sleeve 30, a second end portion of the clutch 60, a substantially cylindrical shape, and a first end portion a second end portion having a plurality of circumferentially disposed around the triangular teeth (not shown), on which the teeth 50 in the sound, teeth. towards the clutch 60, is provided with a shoulder 158. The clutch 60, shoulder radially inwardly between flange 158 is provided inside the housing 154 and the dose scale holder 76 (described below) of the clutch 60, the second end having a shoulder portion 158 of the drive mechanism along a plurality of canine extending portion (not shown) of the clutch 60 by a spline (not shown) connected to the drive sleeve 30, on, in order to prevent the clutch 60 and the drive sleeve 30, the relative rotation between the dose Set the dial sleeve 70 is provided inside the outer casing 154, and the second main housing 4 'radially inward. In the dose dial sleeve 70, the inner surface of a screw thread. The dose scale casing 70, the screw threads of the screw thread 154 of the internal housing 150 engages the second main housing 4, with a window (not shown), through the window you can see the dose dial sleeve 70, the outer part of the surface. Conveniently, the dose dial sleeve 70, the outer surface of the scale with the available set of visual indicia e.g. dose reference numerals (not shown). Conveniently, the second main housing 4 , the window is only allowed to see the scale used to set the current dose. dose scale holder 76, located at the second end portion toward the drive mechanism. The dose scale holder 76, ^ f fixed skin , and thus can not with respect to the dose dial sleeve 70, rotational movement and axial movement of the dose scale holding member 76, having a radially inwardly directed flange 160. The dose scale holder 76, the radially inwardly directed flange 160 having a plurality of canine teeth (not shown), the end portion of the canine Zi along the direction of extension of the drive mechanism to close the clutch 60, the canines. 剂量标度夹持件76,的犬齿与离合器60,的犬齿的接合和脱离接合可在剂量标度夹持件76,和离合器60,之间提供一可释放的离合器。 Dose scale holding member 76, canines and clutch 60, the canines and out of engagement in the dose dial holding member 76, and the clutch 60, to provide a releasable clutch between. 在该驱动机构的第二端部处设置有横截面大致为"T"形的按钮82,。 A second end portion of the driving mechanism is provided with a cross-section substantially "T" shaped button 82 ,. 按钮82,的圓柱形部件朝该驱动机构的第一端部延伸,穿过剂量标度夹持件76,内的开口并进入驱动套管30,的凹槽内。 Button 82, the cylindrical member toward the first end portion of the drive mechanism extends through 76, the opening of the dose dial clamping member and into the drive sleeve 30, the groove. 4安钮82,的圆柱形部件被保持成可在驱动套管30,内进行有限的轴向运动并且不能相对于该驱动套管^走转。 4 security button 82, the cylindrical member is held in the drive sleeve 30, within a limited axial movement relative to the driver and can not go turn the sleeve ^. 按钮82,的圆柱形部件具有沿径向延伸的凸出部(未示出),该凸出部紧靠离合器60,的肩部158的第二表面。 Shoulder button 82, a cylindrical member having a projecting portion (not shown), the projecting portion 60 abuts radially extending clutch, the second surface 158. 按钮82,的第二端部大致为圓形,并且围绕其周向具有朝该驱动机构的第一端部向下延伸的圆筒形围缘(skirt)。 Button a second end portion 82 is substantially circular and has a circumferentially extending around its downwardly toward the first end portion of the driving mechanism of the cylindrical peripheral edge (skirt). 按钮82,的围缘位于从剂量标度夹持件76,沿径向向内的位置。 Button 82, located at the peripheral edge of the dose scale holder 76, radially inward position. 下面将说明根据本发明的驱动机构的操作。 The drive mechanism will be described operation of the present invention. 为了用标度设定一个剂量,使用者旋转该剂量标度夹持件76,。 In order to set a dose scale use, the user rotates the dose dial holding member 76 ,. 响声器50,的弹簧元件沿该驱动机构的第二端部的方向向离合器60,施加轴向力。 Sound 50, the spring element in the direction of the second end portion of the drive mechanism to the clutch 60, an axial force is applied. 响声器50,的弹簧元件施加的力使离合器60,的犬齿与剂量标度夹持件76, 的犬齿相接合以便进行旋转。 Power sound 50, the spring element of the clutch 60 is applied, canines and dose scale holding member 76 for engaging canine rotation. 当剂量标度夹持件76,旋转时,相关联的剂量标度套管70,、驱动套管30,和离合器60,均一致地发生旋转。 When the dose dial holding member 76 is rotated, the associated dose dial sleeve 70 ,, the drive sleeve 30, and the clutch 60, the rotation was consistently occur. 通过响声器50,和离合器60,提供剂量被用标度设定的声音和触觉反馈。 By the sound of 50, and the clutch 60, it is used to provide a dose scale setting of sound and tactile feedback. 当离合器60,旋转时,从离合器60,的第一端部处的齿和响声器50,的齿传递力矩。 When the clutch 60, is rotated, the clutch 60, the teeth and the sound of the first end portion 50 of the tooth transmission torque. 响声器50,不能相对于内部壳体154旋转,由此响声器50,的至少一个弹簧元件变形,以允许离合器60,的齿越过响声器50,的齿而产生可听见的和可触知的"卡嗒声"。 Sound 50, not relative to the rotation of the inner casing 154, whereby sound 50, at least one spring element is deformed to allow the clutch 60, over the sound of teeth 50, the teeth and produce an audible and tactile "clicks." 优选地,响声器50,的齿和离合器60,的齿设置成使得每个"卡嗒声,,对应于药品或类似物的常规单位(剂量)。剂量标度套管70,的螺旋螺紋和驱动套管30,的内部螺旋螺纟丈的导程相同。这使得剂量标度套管70,沿内部壳体154的螺紋150前进的速率与驱动套管30,沿活塞杆20,的第二螺紋24,前进的速率相同。由于活塞杆20,的第一螺紋19,与第二螺紋24,方向相反,因此可防止活塞杆20,旋转。活塞杆20,的第一螺紋19,与插入件16,的螺紋相接合,从而在用标度设定一个剂量时活塞杆20,不会相对于第二主壳体4'移动。连接到该内部壳体154上的螺母40,由于驱动套管30,的旋转而沿马区动套管30,的外部螺紋前进。当使用者用标度设定的药品的量等于药筒可输送的量时,螺母40,到达一个位置,在该位置螺母40,紧靠驱动套管30,的第二凸缘34,。在螺母40,的第二表面上形成的径向止动件与驱动套管30,的第二凸缘34,的第一表面上的径向止动件接触,以便防止螺母40,和驱动套管30,进一步被旋转。如果使用者无意间用标度设定的量大于所需剂量,则该驱动机构允许纠正该剂量而不用从药筒分配出药品。将剂量标度夹持件76,反向旋转。这使得该系统相反地工作。通过离合器60,传递的力矩使离合器60,的第一端部处的齿越过响声器50,的齿,以产生对应于减小用标度设定的剂量的卡嗒声。当已用标度设定所需的剂量时,使用者随后可通过沿该驱动机构的第一端部的方向按下按钮82,来分配此剂量。按钮82,的凸出部向离合器60, 的肩部158的第二表面施加压力,使离合器60,相对于剂量标度夹持件76, 沿轴向移动。这使离合器60,的肩部158上的犬齿与剂量标度夹持件76,的犬齿脱离接合。但是,离合器60,仍保持与驱动套管30,连接,从而不能相对旋转。此时,剂量标度夹持件76,和相关联的剂量标度套管70,可自由旋转(由内部壳体154的螺旋螺紋150引导)。离合器60,的轴向运动使响声器50,的弹簧元件变形,并且使离合器60, 的第一端部处的齿与响声器50,的齿相接合,以便防止它们之间相对旋转。 这样可防止驱动套管30,相对于内部壳体154旋转,但是该驱动套管仍可相对于该内部壳体沿轴向自由移动。从而,施加在按钮82,上的压力使剂量标度夹持件76,和相关联的剂量标度套管70,旋转进入第二主壳体4,内。在此压力下,离合器60,、响声器50,和驱动套管30,沿该驱动机构的第一端部的方向轴向移动,但是它们并不旋转。 Preferably, the sound 50, and the clutch teeth 60, the teeth are arranged such that each of the "rattling ,, corresponding to the drug or the like conventional units (dose) The dose dial sleeve 70, the screw thread and the same as the drive sleeve 30, the inner helical screw Si feet of lead. This allows the dose dial sleeve 70, along the thread 154 of the internal housing 150 advance rate and the drive sleeve 30 along the rod 20, the second thread 24, the same rate of advance. Since 19, and the second thread 24, the piston rod 20 in the opposite direction, the first thread, thereby preventing the piston rod 20, rotation of the piston rod 20, a first thread 19, and the insert member 16, the threaded engagement, so that when setting a dose scale with the piston rod 20, not with respect to the second main housing 4 'move is connected to the nut 154 on the inner casing 40, since the drive sleeve 30, the rotation of the sleeve 30 moving along the horse area, external thread forward. When the amount of the user with the scale setting of the drug cartridge can deliver equal amounts, nut 40, to reach a position in which the position of the nut 34, the first surface 40, against the drive sleeve 30, a second radial flange 34 on the nut 40 ,., formed on a second surface of the stopper member and the drive sleeve 30, the second flange radial contact with the stopper member, so as to prevent the nut 40, and a drive sleeve 30, is further rotated, if the user inadvertently using large scale set to the desired dosage, the drive mechanism allows the dosage to correct without the drug dispensed from the cartridge. The dose scale holder 76, the reverse rotation. This makes the system work contrary by clutch 60, the clutch transmitting torque 60, the first end of the sound over the teeth 50, the teeth to produce a corresponding decrease with the scale to set dose of clicks. When the desired dose has been set by the scale, the user can then pass along a first end of the drive mechanism direction of the portion of the press button 82, to dispense this dose. pressure button 82, the clutch protruding portions 60, the second shoulder surface 158 of the clutch 60, with respect to the dose dial holding member 76, along canine dose scale clamping member to move axially. This makes clutch 60, shoulder 158 76 canines out of engagement. However, the clutch 60, and the drive sleeve 30 remain connected, thus incapable of relative rotation. axial movement of the case, the dose scale holding member 76, and the associated dose dial sleeve 70, rotatably (by an internal screw thread 154 of the housing 150 boot). clutch 60, so that the sound of 50, The deformation of the spring member, and the clutch 60, the teeth of the sound at the first end portion 50, the teeth engage to prevent relative rotation therebetween. This prevents the drive sleeve 30, with respect to the internal housing 154 rotating, but still the drive sleeve relative to the inner housing is free to move axially. Thus, the button 82 is applied, so that the pressure on the dosage scale holder 76, and the associated dose dial sleeve 70 , rotated into the second main housing 4, the. At this pressure, the sound of the clutch 60 ,, 50, and the drive sleeve 30, is moved in the axial direction of the first end portion of the drive mechanism, but they do not rotation. 驱动套管30,的轴向运动使活塞杆20,旋转通过插入件16,中的带螺紋的开口,从而使压脚22,前进。 Drive sleeve 30, the axial movement of the piston rod 20, the rotary member 16 by insert, the threaded opening, so that the presser foot 22, forward. 这样向活塞施加力,使得可从药筒排出20药品。 Such a force is applied to the piston 20 so that the drug can be discharged from the cartridge. 当剂量标度夹持件76,返回其紧靠第二主壳体4,的位置时,该选定的剂量被输送出来。 When the dose dial holding member 76, returns to its close second main housing 4, the position of the selected dose is delivered out. 当从按钮82,除去压力时,利用响声器50,的弹簧元件的变形将离合器60,沿驱动套管30,推回,以使离合器60,的肩部158上的犬齿与剂量标度夹持件76,上的犬齿重新接合。 When the canine from the dose dial button 82, when the pressure is removed, the use of sound 50, the deformation of the spring element of the clutch 60, along the drive sleeve 30, pushed back to the clutch 60, shoulder 158 on clamping 76, to re-engage on the canines. 从而该驱动机构^^皮重置,以准备用标度设定随后的剂量。 ^^ Skin so that the drive mechanism is reset to prepare for the next dose set by the scale. 示例3参照图18-22,可见4艮据本发明的一给药装置。 Example 3 Referring to Figure 18-22, showing 4 Burgundy, according to a drug delivery device of the present invention. 该给药装置包括一两分壳体2",在该壳体内设置有容纳药品的药筒4",用于设定或选定将净史排出的药品的剂量的装置,以及用于排出该选定剂量的药品的装置。 The medication administering device comprises a housing 2 of two points ", provided with a drug cartridge housed in the housing 4", for setting a selected net or a history of drug dose is discharged, and means for discharging the device selection dose of drugs. 壳体2" 的形状大致为圆筒形并容纳齿条6",下文将更详细地说明该齿条。 Housing 2 "is generally cylindrical in shape and houses a rack 6", will be described in more detail below the rack. 药筒4" 位于壳体2"的第一部分8"内。该剂量设定装置和用于排出选定剂量的药品的装置被保持即限制在壳体2"的第二部分IO"内。壳体2"的第一部分8,,与壳体2"的第二部分IO"可通过任何合适的装置固定在一起。 Cartridge 4 "is located in the housing 2" of the first part 8 ". The dose setting means and means for discharging the selected amount of drug that is limiting device is held in the housing 2" within the second portion IO ". Shell body 2 'of the first portion 8 of the housing 2 ,,' second part of IO "may be secured together by any suitable means. 药筒4,,可通过任何合适的装置固定在壳体2"的第一部分8"内的适当位置处。 4 ,, cartridge by any suitable means fixed at an appropriate position within the housing 2 "8 first portion." 针组件可固定在药筒4"的第一端上。在附图中在此位置示出临时盖12"。 The needle assembly can be fixed in the cartridge 4 "on the first end. In the drawings shown in this location temporarily cover 12." 药筒4"还包括可移动的活塞14"。 The cartridge 4 "further comprises a movable piston 14." 使活塞IO"朝药筒4"的笫一端前进可使药品通过该针组件从药筒4"排出。可设置盖16"以便在该给药装置不使用时覆盖该针组件。 Piston IO "toward the cartridge 4" Zi end the drug can advance through the needle assembly 4 "discharge. You can set cover 16" from the cartridge so as to cover the needle assembly of the drug delivery device when not in use. 盖16"可通过任何合适的装置可释放地固定在壳体2"上。 Cover 16 "can be fixed in the second case by any suitable means for releasably" on. 下面将更详细地说明剂量设定装置和用于排出选定剂量的药品的装置。 It will now be described in detail selected dose setting means and the discharge means for the dose of the drug. 齿条6"设置在位于壳体2"中的驱动套管18"内,并通过任何合适的装置相对于壳体2"轴向固定和旋转固定。 Drive rack 6 "is located in the housing 2 is disposed" in the cannula 18 "within, and by any suitable means relative to the housing 2" axially fixed and rotationally fixed. 驱动套管18"包括一内部带螺纹的部分20",其基本沿该套管的整个内表面延伸。 Drive sleeve 18 "comprises an internally threaded portion 20", the entire inner surface of the sleeve extends substantially along. 一内部齿轮22"位于驱动套管18"内,并具有与驱动套管18"的内部螺紋的节距相匹配的螺旋形齿。驱动套管18"的内部螺纹是多头螺紋,其导程等于剂量标度套管的螺旋螺紋的导程,下文将对该剂量标度套管进行说明。 An internal gear 22 "is located in the drive sleeve 18", the drive sleeve 18 and having "the pitch of the internal thread matches the helical teeth. Drive sleeve 18" long inner thread is threaded, the lead is equal to Lead dose dial sleeve of the helical thread, below the dose dial sleeve is described. 驱动套管18"的终端为一外部带螺紋的区段24",其从该套管的端部一直延伸到从驱动套管18"凸出的外部圆周凸缘26"。 "Section as an external threaded end 24 'of the drive sleeve 18, which extends from the end portion of the sleeve to the drive sleeve 18" protruding outer peripheral flange 26. " 一限制螺母28"被安装以便在套管14"的外部带螺紋的区段24,,上旋转。 24 ,, a limit on the rotation nut 28 "is mounted to the sleeve 14" external threaded section. 该限制螺母28"通过多个纵向延伸的花键30" 连接到壳体2,,上,该花键沿壳体2"的第一部分8"的内表面延伸。 The limit nut 28 "extending through a plurality of longitudinal splines 30" connected to the housing 2 ,, on the spline along the housing 2 "8 The first part of the" inner surface extends. 在所示实施例中,限制螺母28"示出为对开螺母,但是也可使用全高螺母。活塞杆32"设置成沿齿条6"的长度延伸并穿过齿条6"的端部内的孑L 活塞杆32,,大体是细长的,并且具有压脚34"。在使用时,压脚34,,i殳置成紧靠药筒活塞14"。 In the illustrated embodiment, the limiting nut 28 "is shown as a half-nut, but can also be used full height nut piston rod 32" is arranged along the rack 6 "and extends through the length of the rack 6" of the end portion larvae L ,, a generally elongated rod 32, and has a presser foot 34. "In use, the presser foot 34,, i Shu set to close the cartridge piston 14." 齿轮22"在轴颈轴承(未示出)中安装在远离压脚34"的活塞杆32"的端部上。大致为圆筒形的剂量标度套管36,,包括具有第一直径的第一部分38" 和具有较大的第二直径的第二部分40"。该第一部分位于壳体2"内。 Gear 22 "mounted in a journal bearing (not shown) away from the presser foot 34" on the piston rod 32 "of the tip. Substantially cylindrical dose dial sleeve 36 includes a first diameter ,, The first part 38 'and a second portion 40 having a larger diameter second. "The first part of the housing 2". 优选地,剂量标度套管36"的第二部分40"的外径与壳体2"相同。壳体2"的第二部分10"包括一围绕同轴的内部套管部分44"的外部套管部分42"。该外部套管部分42"在圆形内部凸缘部分46"处封闭到该内部套管部分44"。 2 "the same as the housing 2" Preferably, the dose dial sleeve 36 "of the second portion 40" of the outer diameter of the second portion of the housing 10 'includes a surrounding coaxial internal sleeve portion 44 "of the outer sleeve portion 42. "The external sleeve portion 42" at a circular internal flange portion 46 "of the closure to the internal sleeve portion 44." 剂量标度套管36"的第一部分38"位于壳体2"的笫二部分10"内, 并位于外部套管部分42"和内部套管部分44"之间。 The dose dial sleeve 36 "of the first section 38" of the housing 2 "undertaking of two parts 10" inside, and located outside the sleeve portion 42 "and the internal sleeve portion 44" between. 第一部分38"的内表面和内部套管部分44,,的外表面具有互相接合的部件,以便在壳体2"的第二部分IO"的内部套管部分44"和剂量标度套管36"之间形成螺旋螺紋48"。 The first portion 38 'and the inner surface of the inner sleeve portion 44 ,, having mutually engaging the outer surface of the member to the housing 2 "of the second part of IO" internal sleeve portion 44 "and the dose dial sleeve 36 "helical thread 48 formed between." 如上所述,该螺旋螺紋48,,的导程与驱动套管18"的内部螺紋相同。 设置在剂量标度套管36"的内表面上的螺旋形肋部可在螺旋形轨道内行进。 As described above, the screw thread 48 ,, the lead and drive sleeve 18 "internal thread the same as provided in the dose dial sleeve 36" spiral rib on the inner surface may be traveling in a spiral track. 这样可使剂量标度套管36"围绕并沿壳体2"旋转。 This allows the 36 "around and along the housing 2" rotating dose dial sleeve. 剂量标度套管36"的第二部分40"具有靠近其自由端的端壁50",这样在该端壁50,,和剂量标度套管36"的自由端之间限定一中央接纳区域52"。在端壁50,,内设置有通孔54"。 Dose dial sleeve 36 "of the second portion 40 'near its free end having an end wall 50', so that the end wall 50 ,, and the dose dial sleeve 36 'defines a central receiving area 52 between the free ends . "50 ,, in the end wall is provided with a through-hole 54." 设置一大致为"T"形构造的剂量按钮56",该按钮的头部58"被保持在接纳区域52"内,并且该按钮的杆部60"的尺寸制成可通过该通孔54"。按钮56,,的杆部60,,具有多个指爪62", 该指爪可变形以便仅在远离剂量标度套管36"的自由端的方向上通过端壁50"的通孔54"。驱动套管18"在其远离该外部带螺紋的区段24"的一端被穿孔的端壁64,,封闭,多个接合部件66"从该端壁突出到驱动套管18"之外。基本为U形的锁紧弹簧68"设置成沿纵向安装在驱动套管18"的外部, 该锁紧弹簧包括通过连接部分74"连接的第一和第二支脚70"、 72"。 Providing a substantially "T" shaped configuration of the dose button 56 ", the head of the button 58" is held in the receiving area 52 ", the lever portion 60 and the button" formed by the size of the through hole 54 " Button 56 ,, 60 ,, the lever portion 62 having a plurality of claws ", the claws can be deformed so far only in a dose dial sleeve 36" of the end wall 50 in the direction of the free end of the "through-hole 54 ' The drive sleeve 18 "in its away from the external threaded section 24" end of the perforated wall 64 ,, closed end, a plurality of engagement members 66 'projecting from the end wall to the drive sleeve 18 "away. a substantially U-shaped locking spring 68 "arranged longitudinally mounted in the drive sleeve 18" outside, by the locking spring comprises a connecting portion 74 'connecting the first and second legs 70 ", 72." 连接部分74"的长度基本等于驱动套管18"的外径。 The connecting portion 74 'of length substantially equal to the drive sleeve 18 "outside diameter. 锁紧弹簧68"的支脚70"、 72,,中的每一个的终端均为一插销部分(latch portion) 76",下文将i兌明该插销部分的功能。当组装该装置时,锁紧弹簧68"朝剂量标度套管36"的端壁50"的内部推动剂量按钮56"沿轴向远离活塞杆32"和驱动套管18"。在此位置, 剂量按钮56"被锁定成与剂量标度套管36"—起旋转。剂量按钮56"同时被永久锁定成与驱动套管18"—起旋转。剂量标度套管36"的第一部分的外表面具有图案82"。该图案通常为一系列参考数字。壳体2"具有孔或窗口84",通过该孔或窗口可看到^表由使用者选择的剂量值的图案的一部分。可通过任何合适的方法将图案82"加到剂量标度套管36"上。图案82" 可直接印制在剂量标度套管36"上,或设置成围绕剂量标度套管36"的印刷标签的形式。 Locking spring 68 "legs 70", 72 ,, each terminal are part of a latch (latch portion) 76 ", below i against the next part of the function of the plug when assembling the device, locking Spring 68 "toward the dose dial sleeve 36" of the end wall 50 "of internal dose push button 56" axially away from the piston rod 32 "and drive sleeve 18." In this position, the dose button 56 "is locked into the the dose dial sleeve 36 "- 56 from rotating dose button." while being permanently locked into the drive sleeve 18 "- from rotating dose dial sleeve 36" of the outer surface of the first portion has a pattern 82 "of the pattern. usually a series of reference numeral housing 2 'has a hole or window 84' through which a portion or window can be seen in Table ^ pattern selected by the user of the dose values can be by any suitable method of pattern 82 " added to the dose dial sleeve 36 "on. Pattern 82" can be printed directly on the dose dial sleeve 36 "on, or disposed around the dose dial sleeve 36" in the form of a printed label. 可选择地,图案的形式可以是夹在剂量标度套管36"上的带标记的套管。可通过任何合适的方式例如激光刺点来标记图案。从驱动套管18"突出的外部圓周凸缘26"具有一对沿直径相对的通孔78",该通孔的尺寸制成可接納锁紧弹簧68"的对应的插销部分76"。 Alternatively, the form of a pattern can be caught in the dose dial sleeve 36 "is marked on the sleeve can be for example a laser dot to mark pattern thorn by any suitable manner from the drive sleeve 18" outstanding external circumference flange 26 'has a pair of diametrically opposed through holes 78 ", the size of the through-hole can be made to receive the locking spring 68" corresponding latch portion 76. " 从凸缘26"的外边缘突出的响声器突出部80"与每个通孔78"相关联。在图18中,给药装置具有一装满的药筒4"。 Each through hole 78 "is associated. In FIG. 18, the administration device filled with a cartridge 4" from the flange 26 'of the outer edge of the projecting portion 80 is projecting sound. " 为了操作该给药装置, 使用者必须首先选择一个剂量。 To operate the drug delivery device, a user must first select a dose. 为了设定剂量,使剂量标度套管36"相对于壳体2"旋转,直到通过窗口84"可见所需的剂量值。驱动套管18"连接在剂量标度套管36"上,并且在用标度设定期间以相同的速度旋出。在用标度设定一个剂量期间,锁紧弹簧68是直的,并朝剂量标度套管36"的端壁50"的内部推动剂量按钮56"沿轴向远离活塞杆32"和驱动套管18", 从而提供一离合器机构。 To set a dose the dose dial sleeve 36 so that, "with respect to the housing 2" is rotated through the window 84 until the "desired dose values visible. Drive sleeve 18" is connected to the dose dial sleeve 36 "on, and During setting the scale at the same speed spin out. In setting a dose scale use during the locking spring 68 is straight and toward the dose dial sleeve 36 "of the end wall 50" internal push dose button 56 "axially away from the piston rod 32" and drive sleeve 18 ", thereby providing a clutch mechanism. 因此,驱动套管18"在位于其内部的齿轮22"上方旋转。 Thus, the drive sleeve 18 "22 located inside the gear" above rotation. 驱动套管18,,和壳体2,,之间的相对旋转使正在被用标度设定的剂量通过两个响声器突出部80"与花键30"的接合而生成声音确认,该花键沿壳体2"的第一部分8,,的内表面延伸。限制螺母28,,与被设定的剂量成比例地沿驱动套管18"爬升。 The drive sleeve 18 ,, and ,, relative rotation between the housing 2 is being used scale set dose by joining two sound device protrusions 80 "and splines 30" generates a sound to confirm that the flower key along the housing 2 "in the first portion of the inner surface 8 ,, extends restrictions nut 28 ,, with the set dose proportionally along the drive sleeve 18" climb. 限制螺母28"的位置对应于药筒4"中剩余的药品的量,当驱动套管18"和壳体2" 之间发生相对旋转时该限制螺母仅沿驱动套管18"的外部螺紋移动。一旦已设定所需的剂量(例如,如图19所示),则为了输送该剂量, 用户按下剂量按钮56"以抵抗锁紧弹簧68"而推动该按钮56"。 Limiting nut 28 "position corresponds to the cartridge 4" remaining amount of drugs, when the relative rotation of the nut occurs when the limit is the drive sleeve 18 "and the housing 2" between only along the drive sleeve 18 "external thread mobile Once the desired dose has been set (e.g., 19), then the dose delivered to the user pressing the dose button 56 "to resist the locking spring 68" and push the button 56. " 随着剂量按钮56,,压下弹簧68",在剂量按钮56"与剂量标度套管36"之间的离合器脱离接合。从剂量按钮56"施加在剂量标度套管36"上的轴向力使剂量标度套管36"在剂量标度套管36"和壳体2"之间的螺旋螺紋上旋入壳体2"内。锁紧弹簧68"变形,且该弹簧的支脚使驱动套管18"沿轴向向下移动。锁紧弹簧68,,的插销部分76,,接合在位于从驱动套管18"突出的外部凸缘26"上的通孔78"内,并保持凸缘26"的响声器突出部80"与花键30" 之间的凹槽的接合,从而将该驱动套管锁定在壳体2"上,并防止在分配剂量期间驱动套管18,,相对于壳体2,,旋转。 As the dose button 56 ,, pressure spring 68 "in the dose button 56" and the dose dial sleeve "between the clutch is disengaged from the dose button 56" 36 in the dose dial sleeve axis "imposed on the 36 to force the dose dial sleeve 36 "in the dose dial sleeve 36" and the housing 2 "screwed into the screw thread between the housing 2". locking spring 68 "deformed, and the spring leg to make drive sleeve 18 "moves axially downwardly locking spring latch 68 ,, 76 ,, engaging portion located from the drive sleeve 18 'projecting external flange 26" on the through hole 78' inside and to maintain flange 26 'of the sound control protrusion 80' 'between the engagement groove, thereby locking the drive sleeve housing 2 "and the splines 30 and prevents the drive sleeve 18 during dose dispensing ,, 2 ,, rotation relative to the housing. 因此,可防止驱动套管18"旋转, 并且该驱动套管沿轴向移入,从而使齿轮22"相对于固定的齿条6"旋转。 齿轮22"连同该齿轮安装于其上的活塞杆32"沿齿条6"移动一段距离,该距离等于驱动套管18,,沿轴向移动的距离的一半,从而生成2:1的机械利益。 Thus, the drive sleeve 18 prevents "rotation, and the drive sleeve is axially moved, so that the gear 22 'relative to the fixed rack 6" rotary gear 22 ", together with the gear 32 is mounted on the piston rod "along the rack 6" is moved a distance which is equal to half of the drive sleeve 18 axially movable ,, distance, thereby generating a 2: 1 mechanical advantage. 这样带来的双重好处之一是对于活塞14"在药筒4"内的给定行程,即对于将被分配的给定量的药品,可使剂量标度套管36"上的显示更大,笫二个好处是使分配该剂量所需的力减半。朝向给药装置的第一端驱动活塞杆32,,穿过驱动套管18",从而使药筒的活塞14,,前进,并排出所需剂量的药品。 One advantage of this is that the dual piston 14 for a given stroke "in the cartridge 4" inside that will be allocated for a given amount of drugs, can display a larger dose dial sleeve 36 "on undertaking of the two benefits is the force required to make the dose distribution in half. towards the delivery device 32 ,, the first end of the drive rod through the drive sleeve 18 ", so that the cartridge piston 14 ,, ahead and discharge required dose of drugs. 活塞杆32"继续前进,直到驱动套管18"和剂量标度套管36,,返回其初始位置(图20)。 Piston rod 32 "continues to advance until the drive sleeve 18" and dose dial sleeve 36 ,, returns to its initial position (Figure 20). 可见,在逸棒剂量时剂量选捧装置和剂量排出装置延伸到壳体2"的第二端之外,并当排出选定的剂量时返回壳体2"内。 "Return of the housing outside of the second end, and when discharging the selected dose 2" can be seen, in the Plaza Bar dose dose dose of holding elections means and discharge means extending into the housing 2 inside. 需要时还可输送其它剂量。 Other dosage can be transported when needed. 图21示出随后选择的剂量的示例。 Figure 21 shows an example of a subsequently selected dosage. 如上所述,限制螺母28,,沿驱动套管18"的外部螺紋的位置对应于药筒4"中剩余的药品量,从而当螺母28"到达外部凸缘26"且不能进一步旋转时,这对应于药筒4"中没有剩余药品。可见,如果使用者打算选择的药品的量大于药筒4"中剩余的量,则这不能实现,因为当螺母28"停止相对于驱动套管18"的旋转时,驱动套管18"和壳体2"将锁定在一起,从而防止驱动套管18,,和从而剂量标度套管36"旋转。这样可防止设定的剂量大于药筒4"中剩余的药品量。 As mentioned above, limiting nut 28 ,, along the drive sleeve 18 "corresponds to the location of the external thread cartridge 4" remaining amount of drugs, so that when the nut 28 "reaches the external flange 26" and can not be further rotated, which 4 "no remaining drugs. See, if the user intends to select the amount of drugs in four cartridges" corresponds to the amount remaining in the cartridge, this can not be achieved, since when the nut 28 "stops with respect to the drive sleeve 18" When rotated, the drive sleeve 18 "and the housing 2" will be locked together to prevent the drive sleeve 18 ,, and thus the dose dial sleeve 36 "to rotate. This prevents setting a dose greater than the cartridge 4" The remaining amount of drugs. 图22示出根据本发明的给药装置,其中已排出药筒4"中的全部药品。所示出的根据本发明的装置的实施例还包括最大剂量设定止动件。当剂量标度套管36"被完全用标度设定时,驱动套管18"上的外部凸缘26" 与壳体2"中的内部凸缘46"相接合。 Figure 22 shows a drug delivery device according to the invention, which has been discharged cartridge 4 "of all drugs. Illustrated further includes a maximum stop dose setting apparatus according to an embodiment of the present invention. When the dose scale sleeve 36 "when it is complete with scale setting, the drive sleeve 18" external flange 26 "and the housing 2" in the internal flange 46 "is engaged. 应看到,如果使用者试图设定的剂量超过最大剂量,则这不能实现。 You should see, if the user tries to set the dose exceeds the maximum dosage, this can not be achieved. 当驱动套管18"停止相对于壳体2"旋转时, 也防止剂量标度套管旋转。 The drive sleeve 18 "stops relative to the housing 2" is rotated, but also to prevent rotation when the dose dial sleeve. 外部凸缘44"和内部凸缘86"之间的作用向使用者表明已用标度设定最大刑量。 The role of the external flange 44 "and the internal flange 86" indicates that between the user sets the maximum penalty amount with scale. 25 25

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