CA2687914A1 - Dispensing means with lockable dose adjuster and one way valve - Google Patents

Dispensing means with lockable dose adjuster and one way valve Download PDF

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Publication number
CA2687914A1
CA2687914A1 CA2687914A CA2687914A CA2687914A1 CA 2687914 A1 CA2687914 A1 CA 2687914A1 CA 2687914 A CA2687914 A CA 2687914A CA 2687914 A CA2687914 A CA 2687914A CA 2687914 A1 CA2687914 A1 CA 2687914A1
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CA
Canada
Prior art keywords
dispensing means
remedy
outlet
control part
handle
Prior art date
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Granted
Application number
CA2687914A
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French (fr)
Other versions
CA2687914C (en
Inventor
Todd Donald Ebbett
Rodney Gordon Walker
Colin Standing
Robert Seaman
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Elanco Tiergesundheit AG
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Individual
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Publication of CA2687914A1 publication Critical patent/CA2687914A1/en
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61DVETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533Dosing mechanisms, i.e. setting a dose
    • A61M5/31535Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A61M5/31536Blocking means to immobilize a selected dose, e.g. to administer equal doses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A61M5/31581Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by rotationally moving or pivoting actuator operated by user, e.g. an injection lever or handle
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A61M5/31586Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by rotationally moving or pivoted actuator, e.g. an injection lever or handle
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159Dose expelling manners
    • A61M5/31593Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
    • A61M5/31595Pre-defined multi-dose administration by repeated overcoming of means blocking the free advancing movement of piston rod, e.g. by tearing or de-blocking

Abstract

An animal remedy dispensing means 100 is described which has an elongate handle (10) having a longitudinal axis (A), an inlet (14) for receiving a remedy and an outlet aperture (21). The outlet (21) has a central axis (B) which forms an angle (8) of between 0° and 45° with the longitudinal axis (A) of the handle The dispensing means 100 includes a dosage control part (39) which is rnoveabie between a first position wherein the dose dispensed can be adjusted and a second position wherein the dose dispensed cannot be adjusted. A novel one way valve (15) is also described.

Description

DISPENSING MEANS WITH ~OCKABLE DOSE ADJUSTER AND OIVE YVAY
VAL VE

The present invention relates to dispensing means, for iexaniple animal Eo:~~dy dispensing rr,earisn The ir~ventirn, .e.ates in particular, but not exc!iusÃvelyr to animal _=ernedy dispensing rneans wFa;ch are suitable for use in oral admiNstra:Ron of a remec,"y, Backwouna~ of ~~e Inven0a.n Animal remedies for sheeR: cattle and the like;~re~ applied by a r~umber of methods incIzjdirig topica; or "pour-on" ~~pk:atÃon> ~~~~ ~~p.~'i+watÃc}nr in;ect;on and nasal i3-s~~~ion, Each of at~~~~ ~~ typically dispens~d from a "pistol gr;p" styie dispens;ng means. One such ~.~:spensÃn~ means of the prÃor a; t #s ~~~jwn in Fagure 1 .

As is common with app.scator~ of the pr;orr aÃ;r the tiapplÃcatom~ I has a g_fiutosi or plunger 2 which can be reciprocated vvithin a barrel 3 by squeezing and re;eas3ng a first handle 4 miativ~ to a second handle 5. The liquid tÃ.~ be dispensed is drawn into thc-, barrel 3 through an inlet -~ via a one way k;,let valve 7 vvhen the p;Ã.Ãn~er 2 is withdrawn inside the barÃ=ez 3, and is dispensed through a nozLzlu 8 via ~n.
outlet vaÃv~
9 when t3~~ ~lungeF' 2 is extended towards the outlet varvoe, 9.

~~ the ~~~sppnsÃ~+g means of this type tI~e, oual:et nozzle 8 (oz sip-e-dEe if the dispensing means is an ;n.Iect~.~r)i.s subsiantia,ly aligned Mth the central axis of the barreà w, and the barrel 3 is orientated approximately transverse tn the first handle 4. As a consequenou, the outlet of the nozzle is tjrpicaIiy substantEa3fy parallel to the az~re'arm of the user whe-rs the dispensing means ~~ in use, at least when the user's wrist is in a relaxed positÃon.
When applying an animal remedy to an animal, particularly in ar, eoral for~~~Ãufat3on, the user of the dispenser typi=:aIE4 approaches sz~ tha-t he or she is facing in substantiaily+
thp same dÃrectson as the an#maÃ> If necessary the animaÃ''s ,-ead is r~~~~~ined, and the d:~~enier is orientated so that the nozzle is inside the animai''s t:Ã~ou:;h, T?,,e
2 dispenser is zhen activated and a measured dose of animaà remedy i~, d#sper?::,eci iritf~
the animal's mouth, It is preferred that the outlet of the {-iozzle is behind ;l-ie animal's tot`9q#.#o, tZ,` Ci'iuui'c, that the ma;ority of th6: remedy is ;aÃh >?llowei`~6, `B Thp position - of the i.iser relative to the sub#ecs ari,mal means #ha, he or s:;e Ãnus-t bend their wrist and elbow to a considerable degree in order position the nozzle in the correct position ir, the an,ma;'s mouth. Thk, can be uncomfortable, and can be ?aifgwÃng if a large number of an mals must be. dosed.

Some dispensers of the ~~ior art, such as the onw <,,ftwn in Figure 1, 1have nozzles which incorporate a sma;I bend, for exa,npÃe around 304, in order to position the outlet in a more suÃtab1e, orientation. While this is an improtjemenk over straight nozzles, i: does not alievÃaÃ~ the problem.

~ 5 A~~ additional disadvantage of the pistol grip style dispenser is :t~~t the nozzle ou-:let is often a considerable dis[C~~c-P a.~wwv from the E,.~serfs hand. This impacts on the user's abili~ty to detern-ii,~~ the position of .-he, nozzle in the animal's mouth, and also iÃic,ease::5 the ~~rce wh;oh rriusY be used to correctly position the nozzle if the animal is resisti.-:'g. This can lead to further discomfort for the user, and to injury to the anima;.

As can been seen in Figure 1, the outlet valve 9 is substanfially aligned with the Centrai axis of the barrel 3. This means that any bubbles ir, the ~lu~~ may become trappedi~ the barrel, as ~.~ubtiles tend à ~ ~ccum,.#~~~~ at the top of the barrel 3 and theM~~~re. faÃ1 to pass through the outlet t~aN+e, when the fluid is dispensed. ~~ the bubbles cannot be purged ;:om the barrel fheri the ~~se- dispensed by the applicator will be Erscor:~eci, Many animal health dispensing means of the prior art arre provided vvÃLh means of aCa3Ã.isting the dLnse dispensed wh~.~-`#"# 3"Fe appfic'u`ti? :6s used. Iri many appkati33 s iti i
3.~ critical to the heait?. -o¾ the animal that '~?~~ correct dose is apps''iei:?:

O=-;w example of such i device is that de,.z,~cribed 3Ã? New Zealand pigtei^st N+., 52?w84=
As is cc~mmon, with. 5uch d~.~vir-es, the dose is adjusted by rotation of a dose adjustment dial, referred to as a 'do`.aafie control p'u''Ct' #i"F the patent specification.

Rotation of the dose adjustÃ~~~~~ dial aligns one of a number of ribs provided o.'l the d;aà wiÃh a Ã'ib a;~ the ~.~ur~ger, 'The stroke of the paurger is limÃ~~~ by t? y ~~~~~th of the selected rib.

Dfatents are ~.~rozrided whi^h tend to stop the d:sxl at prese~ected angular posit3~~s which C(.~rre:.~por-0 V:; required dose v:;ll.l?'#'le:>. However, c'?!Ã.C:lf.#dEng ti'If? F'Ã?~i,,-qtaÃ"t:e prov:ded by the detents, the dial can be freely s~.~tated at aÃiy time. This may lead to a user accidentally ar Ãnadvert~~tily ehangmq the 6--ise, and therefore providing an animal with a suboptsma~ ~~~e of remedy.
The terms"arima3 remedy' and "r~~~dy" are used herein to tÃ-Ãc;ude any prepar'a;ion which may be adrTi=nisteÃ~ed to an animai and Er?c(~desdrums, medicines, remedies, ;h~rapeutic prep,.,rat;onsanri the lakf:.

T" term 'dose is used herein ~to denotethe vo'ume, of liquid dispensed by a dispensing means with a saÃiglw stroke of a piston or plunge,r, e:~cept where the context clearly requires Ãrfther~~se<

WhurG an a¾Ãgfe between two ax.~e:~ is quantÃs`~ed, the angle measurpol is ttle acute angle, rather than the obtuse arg;e, Object of ~~e Ms~ention ft- is an object of a prefe, we~ ~n-ibodiment of the pr'es>enà invention to provide ar, an:rnal rumLdy dispensing means which will overcome oF am ralios-aie problems with dispensing means of the prior art, It is an alternative object of a preferred embodiment to provide an anirnai remedy diapi,.,insÃrsg rn~ans which wi;4 provide improved comfort for a user to apply a:^ animal health ro-Ã~~dy tfi an animal.

R :~ a further afterr?ative object of a preferred embodiment to rnms~~~~~e the chance QÃ
t::~aur'na to the animai.
4 it s:> a further alternative object of a preferred embodiment to i rotride ;~
one way vaIve and/or a liquÃr~ dispensing means including such a one ?.+vay -valv~
which wial overcome or ameliorate problems with such one way valves an~/C~' G~#:5e''ns~"rY~."',.s r'f'#er`~.I`3s ~

It ?s a fu_ther afte..a ive ot3;ert of a pr~fe~red embod;ment to pr~.-~vide a d;spen.,xng means with a dosage coriÃro# mect~~~~sm +r~,xhi~h will overcome or ameliorate problems v}Ath the dispens;ng means of the prior art It is a further alternative object to provir~~ a useful choice, ~~tl-ler ot.~ectr of the present in>>entit,in may become apparent from -thG
follGtn: it~g description, which is given by way of example Only.

1~'~ Summaa ~ of the h~~~~~~iofr According t~~ ok-ie, aspect of th-A present invention there is provided an animal remedy dispensing means Ã~~ludi~~ an ~~angate, handÃe means tiaurEr?g a Iongitudina~
axis, an inlet ;or recewing a rp-meUy to be dispensed, an outlet aperture separate from the irile# for ,ai~~ens~,nq the re-iY~edly, the c}utÃet ape:twr~ having a central axis, and flow control means fo, contÃolfi;~~ flow of the remedy from the ÃnW to the outlet, wherein the central ax;s of the outlet aoerture and the longitudinal axis of the e~orgat.~ handle means form an angle Lf betwoeil, 00 and 4Y.

F~~~fenably the central axis of the outlet aperture and the longitudinal axis of the elongate handle means forrrn an angle of between 0 and 35"'.

Preferably the uentr~.~~ axis of the outlet aperture. ÃEi substaiitial[y parallel to the. Ãongitudinal axis of the elongate ~~~~~~~~ means.

P~~~e,r,~~ly, the position of the outlet ~~efture relative to the hand:e-means is ~~ich that when the Ã~ser grasps the handle means ffie cent;al axÃs of t~~e outlui ,~~ertl:,Ãre ~:~kid the fzirezarm cif the user form ar, angle of bet%#een 30 and 90 .

~
Preferably the position of ~~~~ outlet aperture relative to the handle means is such that when the use¾-~~ ~~~ the hazidle, the central axis of the outlet ap~rture, and the fo,~~~in of the user form sar, angle of between 40" and 700.

Preferably the position of the out;e4 apcnlure relative to the handle means is ~~ct', that when the user ~~~sps the handle, f~~e central axis of t," outlet aperture and the forearm of the ~~~r fo_ m a~ : angle of su6sianti:al'sy 60" .

Preferably the inlet is proximate a f#rst. ~rid of the e(ongat+~ ~andI~ means aÃid x1he _3utiet '10 aperture :s proximate a second end of the handle means, opposite the-first end.

referab1y the distance between the centre of th~ outlet aperture and the longitudinal axis of the eIt.r3~~~e handle m~~ns, is between Omm-38mm.

P~~efer.ably the distance ~~tww-~en the Uentre of the outlet aperture and the iongitudÃnai axis of the eIong;~~e, handle mearis is between 10mm-35mm, Preferably the flow contro' means includes a flow control member, and relative movement of the flow P-ontrol memtbe.T towards the first t,arid(e causes the remedy tÃ) flow from the t:.~utiet.

Preferably ~~~ ~~~~ensingmeans includes a b-arrel witi a plunger recip:~oc~~~~~ ~~~~thi~ the barrel upon relative movement of the first handle and the flow control membeÃ;
the barre;
provided with an inlet port i~i fluid communication with the Ãniet, and an outlet port in fluid communication with ~~e. outlet aperture, wherein a central axis of the barrel and the (ong;tudEnw axÃs of the first handle form an angle ot between 60& and 900, or m~re.
preferably ~e~hxeen ?Ã~~ and 90",,, Pre:~~~~~~ the ~en:r~.~! axis of the barrel and the ;ongitudEnw axis of the first ~~~~~le, form ank angle of subsianfiWly 90'.

Arrordpng to a second aspe,.t of the. present invention there is provided an animal remedy dispensing ~~~~~~~ inciuu~~ig an elongate handle means, an, inlet for reveivisig a remedy to be dispensed positioned proximate a first end of thenandle, an outlet for dispensing the ~ ~~~~~ to be ~~spensed posÃtÃoned prW mmate a second end of tne hand#e opposiÃe, the ~
first a:~~, -and flow control r~~~~sftor controflar~g flowof "ie reÃ~eklyfroÃ~~ the inlet tk3 the (;u a;6?t, Pr~~~~ab;y the Now control means includes a flow control member, and wherein relative r~ovement of the ffovf control member tow~.~rdl,'w the first ~and~e causes Ul~~ remedy to flow from the outlet.

Preferably the dispensing meansinclu^e:; a barrp-l and a pEtanger-reciproc.~~~e wÃtNn the barre; upori relative movement of the first handle and the flow control member, the barrel provided wix~ an ;n1et port Ery ~luld c~.3:~mur~ication w:t~~ the imet, and arvt oufl~~ port Ãn fiLzÃd Wt~mniunicatbon with the outlet, and whereiEi a central axis of the barrel and thts longitudinal axis of the first handfl~ form an arG(.: of between 60` and 900, or more prof~~~~~~~ ~~~~een 70-" and 9W.

Preferably the ceptral axis of the barrel and the ~or),g;tuc,4inal axis of the fÃrsst rxanda~ form an angle of sub~tanti~~ly 90`:

P3~~,efera;~ly the distance between the centre of the outlet aperÃu: e and a Iang;tud;nal axis ~~~~ ~he, ela;ig~~e handlFs means ~~ between Ornrn-38m~:, Preferably the <Ji;~~ance between the ventr~ of the outlet apeÃ`tkure and the longitudinal axis of ~~~ ~~ong~~~ handle means ;s between 10mma35mrÃ;.

According to a giÃ~d aspect of the present invention there is provided an animal remedy dÃspensir~~ ~~~~~~~ inc{uding handle means adapted to be grasped by a user's hrand, ~ r' m(4Ã for receiving a remedy to be dispensed, an outlet aperture separate from the inlet for di,,spens,i~~ the rer~~~dy to be dispera~ed, the outlet apertu3e, ~av~~~ a central axis, and flow c.ontror means for control,i,~~ ~ow of ~he remedy tror~ the rnlet to the autsex apeÃ~~Llre.>
wherein the pcsation of the outlet aperture r~~~~ive to the handÃe meansÃ~
~~ch tt~~~~ ~~hiar~
the user graspM the handle ~~ans, the central axis of Vne outlet aperture and :h* ;oÃ~~~rm of the user forn; an angle of k?etw~~~~ 301 ancl 90'.

Preferably ~~ie, position of the outlet apertLire relative to the harzdle means is such that when the user grasps the handle, the central axis of the ouiiet aperture and the forearm of the user -form aÃi wiz,le of ~~tween 40" and 70 '.

Preferably the position of the outlet aperture re(ativp- to the h;;ndÃw means is such that when the user grasps the hands% the cerikral axir of the mitÃ~~ aper;u~~ and the foÃ~~arm of :. user form ar, angle of substantially 60", Pret-er-a~ly the flow f:.ontÃ~~~ means ÃncÃudes afÃow control ~em~er, wherein reiafi~e movement of the flow control member towards the first handle causes the rp-medy to fÃo-w from the outlet.

Prere~raN'y the dispensing means includes a barre; and a plunger ;ecÃwrocable.
wÃthip, the barreà upon reIati~e moYremenà of the fÃrst InandlEr and :he', flow c omz;o, memb. Ã', the barre;
provided with an inlet port in fluid communication with the mÃet, and an outlet portÃn #Ãu:d ~>ommunic<.t#on wÃtÃ, the oudef ~pe~~ure, whe.rW#n ;~ cembral akis of the barrel ar~~l the ÃoingÃtudinai axis of the fir%t hand;u ;~~~ ~ an angle of ~eh-veen 60 and 9~,~', or mo~~
115 preferably ~~hiv~en ~~~ and 90"P

Pmferably ttie central axis of the bauel and the iorigÃtudinaI axÃs, of the first handÃw form ail angle of subsfant'iaÃÃy 90*, ;..'~:.< Preferably tho, distance k~~hiv~~~ the centre of the. outlet app-rture and the longitudinal axis of the elongate handle mwwis is between Omm-38mrn.

Preferably .he, distance between the centre of the outlet aperture and the longitudinal axis of the elongate ? ~~~~~~e means is between ~ 0mmN35mm.

Aouordsng to a fourth aspecs. of the ;;~~e,~ient invention there is provided a liquid dispensing mearis,f in y,'~?a't#I .Ã.i3:.'}.r a33 animal ric-i{5-~t..'dy dB'~-~.s'peE'isIng #'ne{.~ns according to t3`3~.~.
fÃrst.r second or third aspect, provided with ~:~ dosage c~.~ntro~ mechanism including a dosage ~o.ntrof part mo0~~arbÃe between a first pcisitÃon whereir, the e~~~','. d~spem~ed by the liquid d:~pemaing means ra.^r, bes~~justed, and a seconLI position wherein the dose dispensed cannot be odiustGd:

Preferabiy the- dose is adjuu~aNe by rotation of the dosage control part about a;-i axis of rotation, and Eno17emen"E of the dosage control part betk5i$:"et'"# the first position a",,d ~
the ~~~~~d pos3t3oÃ~ ~ncludes a movement paralI~~ to the dErect#on of the axÃs of "t3:c`at o i1.

~~~~~~~~ly the ÃÃquid diqpensing r-neans in~~~de~ a hou5#ngr and the dosage control !`y..aP"t is rotatable within the housing, whpmIn oÃ"9e of th6f housing a:^d the dt?.t''.~.-age control part is provided wi:h at least one protruding member and the other provÃ,~~d with a plurality (if grooves or channels, adapted to receive at ~east one of the at ~east one urotrudiÃ-:g members when the dosage control part is in th,:.~ so'i;:o:~d pc7s3t;of3.

PreferabÃy the at lG-sast one orc:frudir3~ ~embaw:.= fnc;uwe's, a p>uralifiy of r:bs.
Preferably ihepIuralfty of grooves or channels are definpd by spaces betw~er) a plurality iaF second ribs.

Pmf,~~~~~~ activation the dispensing me~ns, moves the ;-lo~~ge. G:cfntroà part from the first posaÃon to the second position, if the dosage control part is not ~~~~~dy m the second position when tlEt: dispensing means is activated.

According to a fifth aspect of the ~~~~ent invention a one+u%ray valve #ncludlng a v+ zalve body ha~.ring a;t aea.zi one ap~rture therethrough, a ~~~sure means adapted to a;Ão~~~ a fluid to flow through the at least one aperture :n a fj;~l: direction and to substa5 tially prevent a fitsid fe-o,n flowing through the at least or,e aperture ir, a second direction opposite to the first direction, wherein the vMwu+~ body is provided Mti~ a flow path for receiving a fluid flowing in the second direction and directing the fI~ld :~ a required IcfcatEon.

Preferably the flc.~w path extends arouk-id a periphery of the u-als}e body.

Preferably thc- valve body iÃic~~~~~s a substaÃ3ti:.~~y oy3indrical or ffusto-conEcal portioÃi and the flow path exter~dc., between radÃ~.~aly o~~~~~te. sides of;he sÃ.Ã~~tantaallv cylÃndrÃca; or fÃ-usto-cm-iÃca[ porlt;on:

Preferably the valve body is g..~Ã~~~~~edi with a vWve gLzÃdo- , and the closure means incÃu~.~e~B
a valve head and a valve ~~~rn sFidir:~~~ ~~iga.~~d with ;~~e valv+f--~ guÃde, Iq Pr~~ercabÃy the doyure meaÃis includes biasing means for biasing the -vaIve head towards.
a ~~~jhng mea3-is.

Prefera~.~ly the f;ovvt ,, arh incÃudes, a channe(.

According to a sixlh aspect of ~~~e present Ãnventior, ;there is provided a liquid d;spensÃÃ~q means, in particular aii anÃma; reÃ~~dy dispensing means according to the first, sec~~~~~z,, :hiÃ-c~ o~r fourth aspect, induding a one way valve according to the fifth aspect.

Preferably the liquid dispensing means includes a barrel, aiid the flow path includes a :avÃty deÃi_ied by the chanÃ~~~ ~ntl i~~~ ~~arrel.

According to a seventh aspect of the p_ eserif invention there is provided a liquid dispensing means ÃncludÃr,,g a plunger reciprocable within a ~arre;; :hc-liquid dispens;m, means iriclusliÃ~~g an ;niet -and an outlet in fluid communication with the barrel, then liquid dispensing rsieans fi~~~pr including a fIow pat*i b : iwee~~ an are~.~ at or adjacent a top of the barrel when the liqu:id dispensing means is'~~fld iÃa nc~zma; Ãn-use position, and the outiet.

Pref-,-,~rably the Hqu:d dispensing means includes tklie t~~e. way valve of the fifth aspect.
According i~ a further ~spec: of the pmsent invention there is provided ar.~
aà ÃÃmalrerÃ~~dy dispensirq means acc~,~rdirig to the first and1or second and1or third aspects in combination with a ;~quÃ~ dispensing means of t4-:~ 'lloÃ.Ãrth aspect and/or the seventh aspect ~~nd<<r 'a oneiv:~y valve according of the fi~~~ aspect.

The:nvention also broadly consists in any novel feature or combÃnatior, of features disclosed herein.

&!,f DesErri~tio~ of the F!gure-,z Ftgure 1 Is a cross-sectmn side vFevv fif ar) a;3imaF remedy d:spensing means of .he prior ~rt.

Figure 2. Ãy a side perspet.v"ve a+Ãew of a d ~pensÃrg k-ne~~~ of the present invention, with the dosage control part iri a locked position and the plunger wEthdP aJ"v' n,
5 _ Ãgure 3. Is a cross secafoa side view of dispensing means of Figure 2, with the dosage control part is?":~"Jwn #i: Lhe, 13nÃociied position and the i3Ãu?`g43"
vu.th dr?wi'i.

Figure 4. Ãs a cross section side view of the dispensing means of Figure 2, with the dosage control part shown in the unlocked position and the plunger aÃ;rnast ftÃÃiy extendled into the barrel.

Figure 5. ~~ a cross section side v;eiv of the dirpensErig means of Figure 2, orith the p1unq;:r in the fuÃiy uxt~,~:r-~~~d position and the sf::ct,~~~d handÃe having pushed the dosage control part ~~ the !,oc~ed posÃt;~~.

RgUi6; 6. Is a front perspective exploded view of the d1>;;en:`sl#'3t'~
i'meai'1:5, of Figure 2.

F:gum 7. Ãs a rear perspective exploded view of the dispensing ~~~ans of FigLire "?, with the seQ~.~rid haridÃet plunger arsd abÃÃtrzierit: Ã~~~ ry~ber omitted for cÃarÃty.

FigU{~~ 8 N,. a sidp ppr~~ective view of the one wf~y inlet `4faÃve-Figure 9< Is a top view of the one k+~~ay valve of FÃgLire 8.

Figure 10: Ã~ ~ bottom view ofrhr: one way va Ã~~ of Figure 8.

FIgE.ii -~.' 11 is a .~~iii.aE? 3SerSpect#ve view of a si?i_.~.=3nd preferred embeodEfFrePlt of ;'twfo-dÃsp;Nnsing ;nean:: of the pre:~en. invention with a flow control member in, a dispensing p~:.`ss3t;on.
6 PCT/EP2008/057922 Figure 12 is a cr~~~~~ect#on side view of the dispensing meaÃis of Figure 11, with a flow r-rs~~~rol merralber in a return or rest position, Figure 13 :~ a cross-sectEo;-~ side view of Ãhe. dÃ4~.-~tnsmg means of F-Jgu3.e 12, with the 'Ãso;,"ur c~,'~neE'G~~ member in fhe dts.3_:eÃ"1sif~:Fg position, . . , of ~igur;~ 14 ls a ~:q~<:~~, ~--seciEon s#~~~ view of a tl-~Ãrd embodiment os dispensing means, held in a pos3,Ãefn to allow the flow control member to be operated by the user's fingers.
Figure 15 Is a :.ross-sect;on side view of the es'nbod#mer~~ shown in Figure 14, held 9;a a position to ~~~nw t3`l~.' control member to bie opE:?w$+~,~ by the user's ihumb.

,~~~t Mades fof PeHs~~~~in~ ~~w Invention Referring first -;.~.~ Figures 2 to 5 a dispensing means a,:cordÃng t~,~ one eambodÃrrlrr)t of the present invention is generally ieierea:ce+~,~ *100, In the embodiment shown '."{"Ira i~isg"~~'ÃisEi"~g à ~eans 100 is an animal remedy dispensing F~er~83s aL~
~R~3tf~L3~ fi:3; ~:~~'` as an ora~ drencher for sheep or cattle, although it may awso be suitable for use with other animals such as goats.

The dispensing r~~ar~ 100 includes a fi>5t elongate t;aridIW means 1I0 ~av6Ã-,g a aangitu~,~~ina; axi> A, best yeen in Figure 3. A barrel I I is provided at one: ~~~ of the har~d~'e 10, and a piston or plunger .2 inside the barrel 11 Es res,Ãpro,^:~~~e u<;a~~~ ~he, control of flow control member, which may be, a second handle 13, or a :rig~~r or the ke. The secon~.; handle 13 may aciuwze the plunger 12 directly, as i's shown in the figures, or via a separate push rod (~~~ shown).

The liquid to be, ,aisperised is drawn into the barrel I I through an inlet 14 via a one way in3eE valve 15 when the plunger 12 is watIndrawn i,zsif~~ the barreà 11, a>3d is dispensed through a nozzle 16 via an outlet ~~lvu 17 when the plunger 12 is extended toi7~~~~ds, an cutle~ aperture 18 in the barrwl.

The "dose" d3~~enses~ by the di s,~ensi~g mF ans 100 is determi~~d by the voÃL;Ã~e si\<R+-?p't by $.Ã~-, pIi.;nger 12 as Ãt moves between a b"m'ithd#"c';.Wn, posat#iin, as stio4"u`n i#'3 Figure 3, and the fully , extended prss:tiÃsn .~,,? own iÃ3 Figure 5.

The outlet port 18 is in fluid C~.-~mmunit;ation wilh the one way o.AÃ~t valve 17 which is provided at the opposite end csf the f itst handlP- 10 ~rom the barrel 11 The 4uflet vai~~ 17 ;s iEl turn in fiUid COMM ii ni.;atÃo n mt~ an outÃet aperture 1 Q-to 5e~+hich as:
"snlet iapArtu~e 20 of the nozzle 16 :s connected in use. The nozr:lp I fi has an outÃ~~
aperture 21 at the oppos:te end to t~:e nozzle inlet 2C~`~. The uullet aperture 21 has a central axis B.

Ãn use, an animal health ,G-s:~edy is admsn:st.~r-ed to an ammaI by pos:t:onÃng the 3"3o,Lzle 16 ae.; vhat the GLFtlet aperture 21 is lils,dw ti":e anlf-f3aÃ's rF'#F:~.'uth a?'Bd sqElCÃ:z32'1g tho second ~~andÃe- 3 towards t?le first Ã~~nd"!~e 10, as uho3+i+n in F-igur~.~~ 4 and 5.
This causes the plunger 12 to force the preparatiorz residing iÃi the barr=eÃ
11 through tht: outlet pnÃ-t 1 S ~~d hence Vhroug=Y the outlet valve 17 and the out1et aperture 2 1, The second handle 13 is then released and a biasing means such as a ~onwio~~
spring 22 returns the 4.corid hand~'e 13 and the pitAnz3er 12, to the rest position shown in Figures 2 aiid 3. The retur;, rnovememà of the plunger 12 ~~aws. a pfe.a.'ete:m:ned dose of the preparation from a suÃtab:e source, through Ãr,o inÃet 14 and into the barrel _'@ I through the inlet v~i've 1 5. As can be seen from Figu.e4 2 to 5, in a preferred ombodÃment t;;e first and second hanc:~~es. are rotataWly 4on:~~~~ed at the:
end of the handles distal the barrel 11 .

An important feature of the dispensing means 100 is that the central axis B of the outlet aperture 21 ft3rm:~ an angle 6 )-~f betweÃ::-E 0 and 42.5 , or more prefe¾`abay ~~~~me-en 0' and :~~5', with the longitudinal axN. A of the first handie 10. In this way the ar,,g':e between the central axEs B of the nozzÃe, .sutÃer 21 and the forearm 23 of the ureg~ ~s between 300 and 90y, or more pYefeÃ'ab>y bet~~~~r, 400 and 70 , when the user has his or her wrist in a re;axe~.~ posivion;. as best seen ~r, Figure 2õ This r~~uces the ~~~eed for the ~ser t~.~ berid his or her wrist in order to in~~r, the nozzle 16 into the n'louth of t,t~~ anÃmaà (not sh~.~wn), In the most preferred embodiment the central axis B of the outlet aperture 21 form-, an aing;; of around 32 to the k3ngit~~inal axiq A, meaning that the axis B forms an angle of substanL'ral:;y 60' L'SfÃth the uuu~ ~~ fo3 Ã;a3 rn.

The distance X be.weer-s the l~.~~.:~g#tL3diiial axis A of the first ~~~n6e 10 and the cen:ro o~~~ the outÃe~ aperture 21 is ~~Pterak~~~,r rala-tively small, for example betweerl Oiiim -38t'nB`F'#, or r#'3C7rt' S3rE'fek abiy "Ã 0,mm-3",mm>
~

The first handle 10 is preferably ;.rnvFded with a s^ddwned base p~.~itMr, 24 'wh#wh i5 d3menso#"{eist1 as tto, be, substantially ancapabÃe of entGnng $;;e. mL7L#th of c'sF`9 cÃ'l#mal with wths~~ thp- {#spenser 100 is iritended to be used. 'Tr,e widened base ~oni~~ 24 ~~rms w~ stop, ~he=et,,y air~idÃfig probÃems wi~~~ the user EnsertÃn~ th, no.~
_.Ã~ 16 too deeply i n:o th~: animaÃ`s morEth; such as mGy e.fccuw wc;h the di~ ~~i-iwers of the prior arl, AÃthough it is zpreferr~~ that the ha~~~~ 10 be p:s~wÃdRd with a widened base z ort:on 24, p:efbler~s witY: determining how far to Ãnserl Ihe nrzz;e ir~t-o the anÃmai's -riuuth may be aÃl.:viazed to some extent even without the wideoed ;~or~i~n 24 in view of the extra sensitivity provided Liv the pos:tÃ~~~~ of ~he. nozz:e 16 :,e;ativ~.x tc:f the handÃe 10 and the user's hand 23, Referring next to Figures 6 iind 7, a preferred r~ecE-;an;3m for varying the dose dispensed is c~~scribed, The dispensing means 100 includes a housing 25 which is connected to nr i~~eqtw with ihf., first NaÃ?d;e 10. Tf:~in, barrel 11 is connected to or formed integrally wi~~i the housing 25.

The dosage control fyiechar,ism Ãncludos an, abutment member 30 wh>ch is sÃÃdab;y engaged with the plunger 12.. `~he. abutment rTtem~.~er 30 is keyed to the plunger 12, for exampi~ by mtywns of one ormore rÃk~s 31 ipxcvide: or, ~he. pÃunger 12 whiw~~
engage comp1ime~~~ry chinne1s 32 p_'ovided on an internaà s3a3rface 33 of ~~~~
abutment rnember 30. The engagement of the ribs 31 with the channels 32 prevents 'O.atiorf of the abutment member 30 relative to the plunger 12. The 30, plungefis in turn prevented f~oro, moving'rÃ~~8ative to the bodyrof the dispensing means, by its c-or,nectE~~ to nl e second handle 13: as is described further The ~~~tmeeit member 30 is prn-v#ded ~.x+;ih ari externally threaded porton 34 along at least ~~~ of its lenY~th. A substantially cy#iiidri;.aà sleeve 35 is provided which fits over the abutment mernber 30,. and which has a:i i~~terr,aà thread 36 which en~ag P-S
wAh the external threaded portion 34 of the abutment member 30: Tlle sleeve 35 is able to rotate about the pIS:.Fnger 1:' re]atwe to the h::~usÃng 25, but is not able to n-i`v`Lte :ongItud1#3a;ly relative ii'~ th? 4`3i?l.1si33g 25. in a preferred ee Tta?nkl!mi-nt the sleeve 35 Eh prov:dea with afi arinuÃar rib 37 which abuts a pair of inwardly protruding tabs 38 provÃ.~ed, inside the hQus;n~.~ 25, ~~~ of which can be seen in Figure 7.
The tabs 38 prevent the sÃeeae 35 ~~amnioving otitvvLir~,-~ from the housing 25, and the stepped shape of the barrel 11 and 'ht:.~uS3ng 25, iÃOwsY seen in Figures 3-5#
prevents the sleeve 35 :`rom mzivÃng further ;n5>d.;.z Ãhp- housing 25.

A dosage c~~-l-.rol par~t -39 is provkd'ed as a sliding fÃtiover the slaave 35, The dosage co:;troi 39 part ii~ keyed to the s1~evie 35, for example by mea:-ls of Or,e or more Ãongitu:.rÃn;~I ribs 40 provided on an outer surface of the sleeve 35 e.r?~~g~'r-gg one or more Mwardly protruding Ãongitudin;'M ribs 41 provided inside a central aperture 42 :.sf :}-ie dosage, control part 39. The engagement of the 4i:r 4; means that the du-sage control part 39 is able -t~.~ ;nc.~ve longitudinally re3ati4e to the sleeve 35, but aiiy rotation of the dosage control part ' 3u rE'.:iat;ve t~..~ ¾h~f.~' housing 25 also rotates the sleeve 35, The outer surface. 43 of the dosage control part 39 is zfl:sc.~ provided with a pÃu ..,~,y of extennaà ribs 44. The, internal surface 45 of the housing 25 is provided with a plurality of mt{2r..al rab;~ 46 which are spaa_.e~.~ apart tc~ prcvEde. a series of channels or ~rv-oves capable of receiving the emte: ;aÃly prntru~,dÃnq ribs 44 of the dosage control part ~ ~ ~

The dCasage- control part 39 is sUatRle betwe~~i-i ~a first, Ãoc~ied ~o-q#t:or-f, shown in Figures 2 and 5, whe:err, :the ex>prn; Ã ribs 44 enr~~ge- with thp internal rÃ~~~ 46 of t~~e.
housing 39, and a second pasitio~~ shown in rfgi_.~~~s 3 and 4, wherein the external ribs 44 -ake cÃear of the internal ribs 46. When the dosage conzrd ;iaÃt 39 is in the first position the interengagement of the ~~ternal ribs 44 and :nterna; ribs preverits rotatmn of the dr~~~~~ control part 39 relative t~.~ the housing ~~~
However, the~ ÃfmgtE-E ariri position Qt the internal and external ribg- are sL:ch uhat when ~~e.
dosage controà par; 39 is an~.~ved Ãong ÃÃud inal Ã~ aw4y from the 11huus:ng 25 to the -second position, the external ribs 44 are cÃear of Ãhe- ii~tenal ribs 46 of the housing 25, and the d~~~ge, coÃ~tro' part 39 is free to Yo;ate:

Rat-atir?n of the dosage contro~ part 39 raose:s, rotatiom of ~he s1ei-t,,e 35, BecaL.se 5 the t::reL-.~~d porlior? 36 of thp- sleeve 35 is erigaged witt3 the threaded portion 34 of the abutm-:-it i~~~~~bef= 30, ti'-:e longitua:Ãinal position of the abutment member 30 ~:.hanges with rotation of the sleeve 35. The inner end of the abutment member has an abutment portion 47, best seen in Figure 6, which Ãimit5 the distance that an abutment porvo: 48 of the plunger 12 c~~~ be moved i;-iNide the barreà ~~ ~ ~
In this 10 way rotation of the di-xiage coptro3 part 39 chanc~~~ the dose dispensed by the izE''-'pe:^:5i:'Et:3 means 1010, In the embodiment shown r) Figures 6 and 7 the piuÃNer 12 =-riay be removed Trorn, ,he, barrel I I by turning the dosage co: ttrs-A part 39 unti3 !he tiiÃ-eaded ~.~~.~ramt.~n 34 of 15 the abutment 3~~em~.}er 30 disengages from the vleez~e 35, `Thi-, aÃ~ows maintenance of the head of the plunger 1 2. In sf..~rne emb;idimcrits the plunger 12 may be removable by pivoting ti:e plunger 12 so tnat t?^e. outer end 1 2-o of the plunger can be dE:iefigaged from the .:e~~~ 13a Ãn, :'h,,, second handle 13. ~Lnwp-v-i,~-E. it is pgo-fwr{ ed that the pÃun.gei be retained within t.,he sI~~ ~ 3a by a s;.,it;abI~
lockiinc~ means ;,not shcwn#.

When engaged with ;~h- slot 13a the piunger 12 is prevented frcim ru;a'ting, but ;s abl~ to sEi:~~ ovi.t3in the., slot FelatsaFe to the sero nd hand'Ãe 1; to aÃ;ow fior :he a~c-u ate pafth fc,~iio~~~~ by -the ond of the second handÃe 13 as it is ~qLieexed towards the first 2 E) ?-, an d Ãe 10.

:n the embodiment shown trie dose is adjusted by changing the distance the plunger 1 2 is able to wirtidraw within the barrel ^ 7 . The piunge~ 12 reaches the same position in the barro! 11 at .he end of the disper;sing stroke, regardfess of the dose d;spensed: ;n other emb0ciirnents (not si=~ovim) the plunger may withdraw to the sa3'-~e position regardless of the required dose, and the dose control rnay be, achieved by limiting the movement of the plunger away s~orn the fully withdrawn posizion during the dispensing stroke.

A feature of the embodiment shown in Figures 2-7 ls that rr.avement of tl'-3e handles 10, 13 'Ão, dispense a d~Fse will automatically move tÃ'ie dosage control part f'L? ~'~ the second posBtF.s:3n, shown i#'? Figures 3 aF'Fi.a 4 efy the first< ko<,ked position, s~howrl in R~,ures 2 and 5. This means that if the dosage control member part is left 3n the 6 u: kÃocked position, it will be i-noved t~.i the locked pos3-L:Ã.~r3 the next time the dispensing mwansL is >.~si~.~.-~, This may be useful in preventing inadvertent or accidental chz=inges in the set dosage. Ãn the emb..~dirnent shown this self Ãi~xI:Ãng movement is ciused by one of the rafidÃes 1:~ abu2vr-sg :tie ur~~ of the ~~~~~e- controI
parl. 39 and pushing it towards the first position. However, in an alternative embodiment the plunger 12 may be pi'03vliet",Ã with a p3F:rudfflro pa_rl'"noÃ1 such as a tab or the like (nCZt sÃ~own) which performs the saÃ-fie _`unctrc?n, The do-sage ~..ontrc~~ part 30 is preferably provided with detent mea"s adapted tc:F hold it in the fEfst positior3, in the ; rnbodimen~ ~~~kivn the dosage coslrrol part 39 is provÃded with a plurality of inwardly facing tabs 49, best seen in 1:=Ãg.xre
7, which reI~~~~~ly engage depressions or aperti:ares~ 50 in the sleeve 35 when the dosage control part 39 .s, in the first posision., A second si:nÃ3~r detent mechaE-fism may additionally be provided to i~~~~~~aNy hoÃd the dosage contro.I part 39 in the second position.

Those skilled mr, the awi. w:ÃI appreciate that al'~~oLi4,~ the, dosage control means has ~.~~er3 i:~~~~~ibe~-~ with reference to, its appGÃcatir~~ to an animal heafth rapp,Ã; ata. ,. it mz~y have application to any pistor,,, operated Ãiquid di-spensÃr?g means which disppn;.zss a preselet,ted, aeÃ~~~~able, volume of Iiquid, AcQordingÃ~~ the use of une term "dose" is not intended to Ãimit the ÃnventÃ>>~~ to applications in which the, liquid being dispensed is an an3mal health remedy.

The barrel I I is preferably transparent or a: least transwr:en:,. c-r has a trans,~~~~ i-it or translucent portion 51, best s;":eÃ-i in Figure 2, so that ;Ãir-A user is able tc., perform a visual checÃ<, that it is filling Morreutly,, and that there are no bubbles trapped in the, barrel. Those skilled isi Me, art will ~~~~ec~~te that bubblas in the barre:
11 wÃÃI result :n the dose of preparation dispensed being less than that requ3red:

RereÃnng next to Figure 2 #t can be ~ee- Ã~ that wher, the applicator 100 is lizsld Ãn i.~ normaI
in Ã:as=,:.~ positioÃ~, the barYeI 11 is i;F d su:,star3tÃaily hoÃizont~~
orientabM?n, al.~ough it may be tilted to one s:~~ depending on left or right liaÃ~de:~ users.

~~~~~nng next to F:gu-es 3 to 5 aÃ3d iri partÃc;.Ãla~ to F;~~rres 8 t~.~ 10, Roan be seen that the inlet valve 15 rnc(udes a geneÃa1;}+ c-yIindr;caà or f; usto~conic:.~1 valve body 52 through which a pllur~~~~~ of apertures 53 extend from a first side 54 to an axaally opposite side 55.
A cRowwÃe means 56 is ~~ovcdezl which includes a stem 57 and a head S& The stem 57 is s'idakzlr4r engaged wÃth a guide apeÃiure 58a pÃ~oviued in the va[ve body 52.
""`he, ya;?~~~
head 58 is biased agaanst. a sealÃng means 59, best ~e-pÃi in FigÃ:Ãre 4, by a sui:able biasing Ãi~~e.aÃ~~ such a spring (not ~~ovin). Ãn the embodiment shown thF~ Seal;ng means 59is provided at t.hcz~ erid of the barrel 11, ;.~lthougti iri t~ther embodiments (Ãi{.~~ ~~owri) the head 58 may seal against a seailii:q ^neat'3s which is con!'lecAad to or integral if4rE#,.h the `;+`alv~`~'..
body.
The closure means 5-6 aI Ãows l:qui d i~ flow through the ~~~~~~un~~ 53 from VIhe iNet 4 to the ~~~~rrei 11, but prevents flow in the opposite direction, as is common with oE~e way valve mechanisms of :he. prior rart.

A channel 60 is defined oÃi aÃ~ outer stÃrfaze of the valve body 62, aÃi{~
extends from one side 61 of the body 15 to the radiaEly opposite side 62. The ~~~~~ne! 60 defines a fi+,~w path for the fluadvg}heÃ~ the plunger 12 is extended towards the vaIve 15. The flow path directs fluid from aÃi area at or adjacent the top of the barrel 11 to the barrel o{.ÃtIet 18, which in the embodiment shown is provided in a lower stjzfa..~ of the barrel 11, best seen in FÃ~~~e~,,, 3 to 5. Taking fluid from the top of the barrel 11 ensures th.at any ~~~~,ained air in the barrel 11 is ;.uà ~e,,,', as efficiently as possible, as air bubbÃes iÃ~ ~~~e fluÃd teÃid to rise to the top of ~he. barrel 11.

In a preferred embodiment the channel 60 e-xtef~~~ around one side of the valve bodyr 52 my, in order to, avoid any turbulence which might be caused if the fluid flowed around both sides of ~~~~ body 52 and wasÃ'~cornbÃned iÃito a single str~am. The channel 60 preferably has a area at Ãeast eqtia' A+, that of the ~arrpl outfet18 in order to minÃmÃse the res;staa~ce, tÃ~ ~he, f;uid PtaAfÃng ~~~~~gh the channe; 60, ~~~~reby m#n;mising ihe force necessary to dÃive the plunger 11. Thev~~~~ body 52 preferably fits sr~~~~ly wÃ~~ir, tle barrel 11, so that t~~ flow path is ~~efined by the cavÃty created between the channe~ 6: and the uari e` 11, as best seen in Figure 4.

As can beseen Ãn Figures 8 -10, the channe1 60 is presesabEgs provided vvith radÃussed ,orners, 63. It;s preferred that ~shaYpÃy atigkalar charge;~ in direction Ke avrfaÃded5 as thes-P
uan z au:~~ Pddif-s ~n the fILEÃd fl~ow and,'or areas of low or no ~ow, whi~h may tr ~~ ~ntraà ned air bubbles iÃi thp- fluid flow ar~~ make purging the applicator of air more difficult.

Referring next to Figure 4, a caqduÃf 64 extends ~~hsveenthe barÃwl outlet 18 and the one way outlets`aÃvw 17 provided adjacent ousret rio_ zle, 16. In a preferred emWodime;~t the combir~pd volume La~ the conduit 64 and the channel 60 is less tha3 thevolumÃ;
of f;.jid disp~~~~~ ~~ ~~e~, dispen. ing rneans 100 whvr, set t{3 s~~ ~owest dose settÃng. !~ ~~econduit 64 has a greater volume than the mÃnimum, dose, then at bw dose settings b.
ubbÃe", ~'n the fluid may be carried oniy ~arto~ the wray to the outlet valve 17 with a first dose of `,uic', and m.ay then float ~~~k up the conduit 64 before the next dose is axpre;:~ed.

'i 5 In some embodiments (not shown) the outlet valve 17 may be positioned on.
top of the barrel 11, thereby eÃimÃnating the need k~~ the 3ntegfated 3niet valve {
outlet channel, AI~ema;svely outlet valve coÃ.i1d be positioned immediately under t3 ehtegrafed inlet valve 1 oY..Etiet channel. ~ow~ve,.:, both these options cause the end of the ~-~arre; t:) bQ~ame. ,~~~~~e W~iky.
An addEtÃonW, advantage to havmg th:;, ou:,e: ~~aNe 17 cÃose:~ th-,~ nqzzÃ~ 16 is that :he weight of ÃÃuld:3n the conduit 64 is held by the oLFti~t walve 17, eliminating tiie need -for a nonrd;~~~ valve at the nozzle 16 for most app i+:.ations.

In some efr,bodim~~~~~ a sp?-aeYicaà valve element may be used instead of the head ~~
and stem 57 sho,4x; ;*, in Figures 8 to I <<, S,.ach a baÃi-vaÃve arrangement is well 0-ow to ~~ose skilled in tE~~ art, and may include the use a rubberi~~d baÃ~
sealÃrig aqa;nst ihe end of the ba=rvi, a hard ball with a soft seat, or a high pre, is#:ri, hard-baÃl / hard seat c~.~nfiguration.
AÃtif~ough the flow path ftor~~ barrel 11 to .ht-, :~ozzle outl~! 21 is shown as rucitn~~~~
inside the first handle 10, in less preferred ernt..~odimGnt (not shown) the ;;ozzIe, inlet 20 may connect di:~cfly to the barrel 11, bu'; nioy be 5nag..~-O~.~ S{M that the noU~~
oLA~: t 21 exits at the ~~po;~~te end of ~~p first `~~ndle tothe barre; I I in substantially the ~~me. position as the nozzle outlet shown in Figures ~.'-5.

aieferrinq next t~ ~~gtFres 11r 12 aÃ~d 13,, an aÃ';ernatave embodiment of the dispenssFiy~ means i--- gene:aÃl~ referenced 200, in this emz3ocÃÃnnen4 the dispensing :-neans 200 ~ta~-, fÃ~~t a har;die rneaÃaM 10, and a second har3dÃ~s means 13 hÃngWabÃ,Yr mounted to t3`3e f;t ;>4 handle m::.~z"f._< 10 in a s>d'T3?Ãw cL}iif4gt.EratEi,tn to the embodianen:
shown in Figures 2 to 10. ~ovaever; rr; this emb.ad#~~~~~ the barwe; '1 I :s provided `ms3~~~ the first ;,andÃe means 1:3.

The second handle me-.~.~~s 13 ic, provided with a toothed rack 64 Mhi, h e;-=~agus a gear or pinion ~~~ such that squeaz:ng the second handle 13 towards the first handle 10 causes the rack 64 to rotate the ~~~r P6,315. A pi;..rnger 66 is connected to a tc,~~~he,~
puts,h rod 67 which is pr~~~~aNy engaged directly with the gear 65, a>tho;;gh i;-; ari afte#'native eerrn~od;rnent (not shown) the push rod 67 may be engaged with a second gear ~rvhiuh rotates -qvith the gear 65. I-h~ push rod 67 may be integrally formed vv{Ãth the P1unaer 66, The preparation enters the harreà I I from as : inlet 68 through a fl'ow s.~
.;') 69 in the push rod 67 via a one way iin!e,~t valve 70 which is :ntegra. ~~~,~'th the pi..:nger 6Ã.~, A
one way out=eat valve 17 is provided at the barrel .~~~~~~~

As with tne emb..~dÃrner,i shown :r~ Figures :F; - 5, a nozzle 16 has an ?¾iÃet 20 in fluid with the ?ututÃe~t valve 17 and an o:Aleà aperture 21; The rentraà axis B of the oiiÃÃet ape;~tLire 21 and the longitudinal axits A of the first hanWe 10 form an angle of between 0` and 45` , so 1.hat the angle between ttie nozzle and the forearm of the ~se-r is between :30G and 90' when ~h,- 3_3staY has his or ;-,ei vyr3st in a re.Ãaxed pos#tÃ,on~ The ou~~et vahv+~ 17 is a;so provided at the opposite end of the handle means 10 to the i::;et 68õ

Although the enibodÃment shown in '~igures 11 ..1;a nn:~iy f u^etÃon well, ~~~
embodiment s1h~.~wn in Figures 2-7 may be preferred because the ~~~~~angeEren*
of the barrel 11 with its centraà axis C ai. an angÃe of bepweeti 60 and 9W, or Ãri~..~re pt`~~~~~~~~~~ between 70' and 90'; s~.~ iÃ-3e lorivEtudinaE axis A of the first ~anWe 10 a;Ã~~~~
a more direct actuation of the plunger 12 by the second har:dÃe 13, without t;s~.~ nefad for a rack af~ir-i gear arrangement. This may ~ead to improved reliability of th~,~

a~'3pÃicat{33", and tio an improved "f'L,-`.i',.Ã" as to whether the ~ori ec-z do?~`'-. has been appÃicd, ln a preferred embodiment the centra1 axis C of the barge: 11 forms an ang:e of substa:iaÃaÃly 9i.~ to the Ão,agÃtu~inaà axis A of Phe ?-,,andl~ 10, 5 The feeÃ, and the accuracy and repe;~tabilÃty of the dosage dispensed, may also be improved if the barrel I 'à has a greater length dimpnsion thari its ,.~i ameter< ;~ a preferred embodimena the ;ength to diameter ratio of the barrel is between 2:1 ~nd .2. 6 " 1, 10 Figures 14 and '15 show a .hia all possible embr dimw~ ~t or ;ha d3spen,ing means, genera;ly ref~rc-nved 300. T11h:s ermbodiment of the dispensing :-neans diffierr from tha~~. shown in FÃgiurws 11 - 13 in that the plunger 66 is actuated by a connecting rod 70 which is rotataWy cnnnecte;ll to the second handle 13 at a first end and rotatably connected to the plunger 66 at a second end.
~wt The dispensing means 300 can behc'>it~ so that fln~.' a.et::G3f'iÃ.~ handle 13 is ac'fua3,ud with the fingers, ~~ si-ow~~~ in F:g:are 14, or with the thumb, as showr-i in FigLis-s~ 1 ~~
Mile the examples of, the dispensing meatis of the prehent invention described 20 ~~~vc- are oonfÃgured as oral drenchers, alternative embodiments of a~ie dÃspen.;ng 'n'u`a3"Ss may be configured for use iiv(ih aftema3.3Fte methods of dispensing an animal ,emedv sucf-3 as puur-u~~, nasal m-fusion or Ãn;ject;on.

S1:~~'`3il;.~,;B'lyf +vRfeZ`tBle t:-l~-? dispensing me..=~am, shown is c~
manually acli.:atf`d type, s:3.lte3nan3+,e embod;~~en~~ of the invention m,,ay be powinred electrically c~~by pressurised ~as; or the remedy may be deÃivt-:red to the e-i Ã5pens mg means t:fndef pmssure and the u;spe;^sir~~ means may control the flow of the remedy by opening and a:.~osinc, a ~~~iv,~
between tl'le ÃnÃet and the nnzzle outlet.

,. :
T~iQ~e sI~~~Ãed . ~;~ the art ~~~r~Ã appÃ~e~cia.e that dispensing means made in accordance with the present invention may ~~~ more comfortable to use than the dispensing means csf the prior aftz and f~~ay be Ãe5s fatiguing tc) wie over extended perÃo,~~ of ttmÃ;. Where the preparation dispensed es :~tended -tc.~ be, . waE;~.~wed by the anin-iaÃ, the ds~~em,,ing means of the present lnvent,on mey allow the user :cf position the 2-:1 nt;+'`..~".ze m4}rW :3~. ,curately in the anim'z~`i,n, mouth, 'r3#3d may reduce tne l:kC?`i33ood of EÃ`3;L~#"
tc) -:he ani~~~ during the appFica;ion pr;Xcesso Where Ãri the forego:r~~ ~~scF iption, r: fe:re~ice has been rnade to specific cornp~.~nent~

~ or 37",,'~eger`e of the invention having kn`~.~4+'6+Fi equ#ir`~ients, then such equivalents are herein incorporated as if I$`tsiL'IdIf.EMly set ~'s"Frzh.

Afthcfugh this invention E~ao., been described by way uf exarn~.3;~ and with reference to oossNe embodimei-its thereof, it is to bi~: under-qti.~o~ that rnod#fications or improvements may be made '~~ene-to wlth{Jut departing from the spirit or scope of the appended cla;ms.

Claims (38)

Claims
1. An animal remedy dispensing means including an elongate handle means having a longitudinal axis, an inlet for receiving a remedy to be dispensed, an outlet aperture separate from the inlet for dispensing the remedy, the outlet aperture having a central axis, and flow control means for controlling flow of the remedy from the inlet to the outlet, wherein the central axis of the outlet aperture and the longitudinal axis of the elongate handle means form an angle of between 0° and 45°.
2. The animal remedy dispensing means of claim 1 wherein the central axis of the outlet aperture and the longitudinal axis of the elongate handle means form an angle of between 0° and 35°.
3. The animal remedy dispensing means of claim 2 wherein the central axis of the outlet aperture is substantially parallel to the longitudinal axis of the elongate handle means.
4. The animal remedy dispensing means of claim 1, 2 or 3 wherein the inlet is proximate a first end of the elongate handle means and the outlet aperture is proximate a second end of the handle means, opposite the first end.
5. The animal remedy dispensing means of any one of claims 1 to 7 wherein the distance between the centre of the outlet aperture and the longitudinal axis of the elongate handle means is between 10mm-35mm.
6. The animal remedy dispensing means of any one of claims 1 to 4 wherein the flow control means includes a flow control member, and relative movement of the flow control member towards the first handle causes the remedy to flow from the outlet.
7. The animal remedy dispensing means of any one of claims 1 to 5 wherein the dispensing means includes a barrel and a plunger reciprocable within the barrel upon relative movement of the first handle and the flow control member, the barrel provided with an inlet port in fluid communication with the inlet, and an outlet port in fluid communication with the outlet aperture, wherein a central axis of the barrel and the longitudinal axis of the first handle form an angle of between 70° and 90°.
8. The animal remedy dispensing means of claim 6 wherein the central axis of the barrel and the longitudinal axis of the first handle form an angle of substantially 90°.
9. An animal remedy dispensing means according to any one of claims 1 to 8 comprising in addition a dosage control mechanism including a dosage control part moveable between a first position wherein the dose dispensed by the liquid dispensing means can be adjusted, and a second position wherein the dose dispensed cannot be adjusted.
10. An animal remedy dispensing means according to claim 9, wherein the dose is adjustable by rotation of the dosage control part about an axis of rotation, and movement of the dosage control part between the first position and the second position includes a movement parallel to the direction of the axis of rotation.
11. An animal remedy dispensing means according to claim 9 or 10, wherein the dispensing means includes a housing, and the dosage control part is rotatable within the housing, wherein one of the housing and the dosage control part is provided with at least one protruding member and the other is provided with a plurality of grooves or channels, adapted to receive at least one of the at least one protruding members when the dosage control part is in the second position.
12. An animal remedy dispensing means according to claim 11 , wherein the at least one protruding member includes a plurality of ribs.
13. An animal remedy dispensing means according to claims 11 or 12, wherein the plurality of grooves or channels are defined by spaces between a plurality of second ribs.
14. An animal remedy dispensing means according to any one of claims 9 to 13 wherein activation of the dispensing means moves the dosage control part from the first position to the second position, if the dosage control part is not already in the second position when the dispensing means is activated.
15. An animal remedy dispensing means according to any one of claims 1 to 14 comprising in addition a one way valve including a valve body having at least one aperture therethrough, a closure means adapted to allow a fluid to flow through the at least one aperture in a first direction and to substantially prevent a fluid from flowing through the at least one aperture in a second direction opposite to the first direction, wherein the valve body is provided with a flow path for receiving a fluid flowing in the second direction and directing the fluid to a required location.
16. An animal remedy dispensing means according to claim 15, wherein the flow path of the one way valve extends around a periphery of the valve body.
17. An animal remedy dispensing means according to claim 15 or 16, wherein the valve body includes a substantially cylindrical or frusto-conical portion and the flow path extends between radially opposite sides of the substantially cylindrical or frusto-conical portion.
18. An animal remedy dispensing means according to any one of claims 15 to 17, wherein the valve body is provided with a valve guide, and the closure means includes a valve head and a valve stem slidingly engaged with the valve guide.
19. An animal remedy dispensing means according to any one of claims 15 to 18, wherein the closure means includes biasing means for biasing the valve head towards a sealing means.
20. An animal remedy dispensing means according to any one of claims 15 to 19 wherein the flow path includes a channel.
21. An animal remedy dispensing means including an elongate handle means, an inlet for receiving a remedy to be dispensed positioned proximate a first end of the handle, an outlet for dispensing the remedy to be dispensed positioned proximate a second end of the handle opposite the first end, and flow control means for controlling flow of the remedy from the inlet to the outlet.
22. An animal remedy dispensing means including handle means adapted to be grasped by a user's hand, an inlet for receiving a remedy to be dispensed, an outlet aperture separate from the inlet for dispensing the remedy to be dispensed, the outlet aperture having a central axis, and flow control means for controlling flow of the remedy from the inlet to the outlet aperture, wherein the position of the outlet aperture relative to the handle means is such that when the user grasps the handle means the central axis of the outlet aperture and the forearm of the user form an angle of between 30° and 90°, preferably of between 40° and 70° and in particular of substantially 60°.
23. A liquid dispensing means provided with a dosage control mechanism including a dosage control part moveable between a first position wherein the dose dispensed by the liquid dispensing means can be adjusted, and a second position wherein the dose dispensed cannot be adjusted.
24. The liquid dispensing means of claim 23 wherein the dose is adjustable by rotation of the dosage control part about an axis of rotation, and movement of the dosage control part between the first position and the second position includes a movement parallel to the direction of the axis of rotation.
25. The liquid dispensing means of claim 24 wherein the liquid dispensing means includes a housing, and the dosage control part is rotatable within the housing, wherein one of the housing and the dosage control part is provided with at least one protruding member and the other is provided with a plurality of grooves or channels, adapted to receive at least one of the at least one protruding members when the dosage control part is in the second position.
26. The liquid dispensing means of claim 25 wherein the at least one protruding member includes a plurality of ribs.
27. The liquid dispensing means of claim 25 or 26 wherein the plurality of grooves or channels are defined by spaces between a plurality of second ribs.
28. The liquid dispensing means of any one of claims 23 to 27 wherein activation of the dispensing means moves the dosage control part from the first position to the second position, if the dosage control part is not already in the second position when the dispensing means is activated.
29. A one way valve including a valve body having at least one aperture therethrough, a closure means adapted to allow a fluid to flow through the at least one aperture in a first direction and to substantially prevent a fluid from flowing through the at least one aperture in a second direction opposite to the first direction, wherein the valve body is provided with a flow path for receiving a fluid flowing in the second direction and directing the fluid to a required location.
30. The one way valve of claim 29 wherein the flow path extends around a periphery of the valve body.
31. The one way valve of claim 29 or 30 wherien the valve body includes a substantially cylindrical or frusto-conical portion and the flow path extends between radially opposite sides of the substantially cylindrical or frusto-conical portion.
32. The one way valve of claim 29, 30 or 31 wherein the valve body is provided with a valve guide, and the closure means includes a valve head and a valve stem slidingly engaged with the valve guide.
33. The one way valve of any one of claims 29 to 32 wherein the closure means includes biasing means for biasing the valve head towards a sealing means.
34. The one way valve of any one of claims 29 to 33 wherein the flow path includes a channel.
35. A liquid dispensing means including the one way valve of any one of claims 29 to 34.
36. The liquid dispensing means of claim 35, wherein the liquid dispensing means includes a barrel, and the flow path includes a cavity defined by the channel and the barrel.
37. A liquid dispensing means including a plunger reciprocable within a barrel, the liquid dispensing means including an inlet and an outlet in fluid communication with the barrel, the liquid dispensing means further including a flow path between an area at or adjacent a top of the barrel when the liquid dispensing means is held in a normal in-use position, and the outlet.
38. The liquid dispensing means of claim 37 including the one way valve of any one of claims 29 to 34.
CA2687914A 2007-06-25 2008-06-23 Dispensing means with lockable dose adjuster and one way valve Active CA2687914C (en)

Applications Claiming Priority (3)

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NZ556142 2007-06-25
NZ556142A NZ556142A (en) 2007-06-25 2007-06-25 Animal remedy dispensing means
PCT/EP2008/057922 WO2009000786A2 (en) 2007-06-25 2008-06-23 Dispensing means with lockable dose adjuster and one way valve

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CA2687914A1 true CA2687914A1 (en) 2008-12-31
CA2687914C CA2687914C (en) 2016-03-01

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TR201816419T4 (en) 2018-11-21
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ES2703875T3 (en) 2019-03-12
PT2170216T (en) 2019-01-17
CO6241090A2 (en) 2011-01-20
LT2170216T (en) 2018-12-10
PL2170216T3 (en) 2019-04-30
NZ556142A (en) 2009-11-27
WO2009000786A2 (en) 2008-12-31
CY1121019T1 (en) 2019-12-11
SI2170216T1 (en) 2018-12-31
US8460251B2 (en) 2013-06-11
MX2009013526A (en) 2010-01-27
ZA200907962B (en) 2010-07-28
JP2010531180A (en) 2010-09-24
CA2687914C (en) 2016-03-01
WO2009000786A3 (en) 2009-05-14
AR067169A1 (en) 2009-09-30
AU2008267262B2 (en) 2012-02-02
EP2170216A2 (en) 2010-04-07
DK2170216T3 (en) 2018-12-10
BRPI0812452B1 (en) 2019-08-06
EP2170216B1 (en) 2018-10-17
HUE041515T2 (en) 2019-05-28
HRP20181843T1 (en) 2019-01-11
AU2008267262A1 (en) 2008-12-31
US20100174241A1 (en) 2010-07-08

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