CA2675170A1 - Two piece cancellous construct for cartilage repair - Google Patents

Two piece cancellous construct for cartilage repair Download PDF

Info

Publication number
CA2675170A1
CA2675170A1 CA002675170A CA2675170A CA2675170A1 CA 2675170 A1 CA2675170 A1 CA 2675170A1 CA 002675170 A CA002675170 A CA 002675170A CA 2675170 A CA2675170 A CA 2675170A CA 2675170 A1 CA2675170 A1 CA 2675170A1
Authority
CA
Canada
Prior art keywords
bore
base member
cartilage
repair assembly
cartilage repair
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002675170A
Other languages
French (fr)
Other versions
CA2675170C (en
Inventor
Eric J. Semler
Katherine G. Truncale
Alex B. Callahan
Judith I. Yannariello-Brown
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Musculoskeletal Transplant Foundation
Original Assignee
Musculoskeletal Transplant Foundation
Eric J. Semler
Katherine G. Truncale
Alex B. Callahan
Judith I. Yannariello-Brown
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Musculoskeletal Transplant Foundation, Eric J. Semler, Katherine G. Truncale, Alex B. Callahan, Judith I. Yannariello-Brown filed Critical Musculoskeletal Transplant Foundation
Publication of CA2675170A1 publication Critical patent/CA2675170A1/en
Application granted granted Critical
Publication of CA2675170C publication Critical patent/CA2675170C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30756—Cartilage endoprostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/3654—Cartilage, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00491—Surgical glue applicators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/38—Joints for elbows or knees
    • A61F2/3859—Femoral components
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
    • A61F2002/2839—Bone plugs or bone graft dowels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
    • A61F2002/30057—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis made from both cortical and cancellous adjacent parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
    • A61F2002/30059—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in bone mineralization, e.g. made from both mineralized and demineralized adjacent parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/30224—Three-dimensional shapes cylindrical
    • A61F2002/30225—Flat cylinders, i.e. discs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/30224—Three-dimensional shapes cylindrical
    • A61F2002/30225—Flat cylinders, i.e. discs
    • A61F2002/30227—Flat cylinders, i.e. discs arched, domed or vaulted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/30224—Three-dimensional shapes cylindrical
    • A61F2002/30233—Stepped cylinders, i.e. having discrete diameter changes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/30224—Three-dimensional shapes cylindrical
    • A61F2002/30235—Three-dimensional shapes cylindrical tubular, e.g. sleeves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30317—The prosthesis having different structural features at different locations within the same prosthesis
    • A61F2002/30327—The prosthesis having different structural features at different locations within the same prosthesis differing in diameter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2002/30331—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements made by longitudinally pushing a protrusion into a complementarily-shaped recess, e.g. held by friction fit
    • A61F2002/30354—Cylindrically-shaped protrusion and recess, e.g. cylinder of circular basis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2002/30448—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2002/30459—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements stapled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2002/30461—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements sutured, ligatured or stitched
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2002/30476—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements locked by an additional locking mechanism
    • A61F2002/30492—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements locked by an additional locking mechanism using a locking pin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30604—Special structural features of bone or joint prostheses not otherwise provided for modular
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30756—Cartilage endoprostheses
    • A61F2002/30759—Mosaicplasty, i.e. using a plurality of individual cartilage plugs for filling a substantial cartilage defect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30756—Cartilage endoprostheses
    • A61F2002/30762—Means for culturing cartilage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30756—Cartilage endoprostheses
    • A61F2002/30764—Cartilage harvest sites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
    • A61F2002/30772—Apertures or holes, e.g. of circular cross section
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
    • A61F2002/30772—Apertures or holes, e.g. of circular cross section
    • A61F2002/30784—Plurality of holes
    • A61F2002/30785—Plurality of holes parallel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
    • A61F2002/30772—Apertures or holes, e.g. of circular cross section
    • A61F2002/30784—Plurality of holes
    • A61F2002/30789—Plurality of holes perpendicular with respect to each other
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
    • A61F2002/30795—Blind bores, e.g. of circular cross-section
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2002/30932—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth for retarding or preventing ingrowth of bone tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
    • A61F2002/4635—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor using minimally invasive surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
    • A61F2/4644—Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material
    • A61F2002/4646—Devices for cleaning bone graft
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
    • A61F2/4644—Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material
    • A61F2002/4649—Bone graft or bone dowel harvest sites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0033—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements made by longitudinally pushing a protrusion into a complementary-shaped recess, e.g. held by friction fit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/005—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using adhesives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0066—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements stapled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0075—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0069—Three-dimensional shapes cylindrical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0039—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in diameter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/64—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus

Abstract

The invention is directed toward a cartilage repair assembly comprising a shaped allograft two piece construct (20) with a demineralized cancellous cap (30) and a mineralized cylindrical base member (22) defining a blind bore (23) wrth a through going transverse bore (28) intersecting the blind bore (23). The demineralized cancellous cap (30) has a cylindrical top portion (32) and a smaller diameter cylindrical stem (36) extending away from the top portion (32) which fits into the blind bore (23) of the mineralized base member (22). The cap stem (36) defines a transverse through going bore (37) which is aligned with the through going bore (28) of the base member (22) to receive a cylindrical cortical pin (40) holding the cap (30) within the base member (22). The shaped structure (20) is dimensioned to fit in a drilled bore in a cartilage delect area so that the assembly engages the side wall of the drilled bore in an interference fit.

Description

TW~:) ~'~.~t'~~CT.7 ( ~~~~~ ~d~'~{<.t I~~~::~;
a C.:~ RTILAG:E E.~Alit tR I U1A`11D :~~~~~~::~~ r 10 N 8 =~ .~ , r-;~..:`~ ;.~ 3; ..

OR
- -------------R '~~3 FEDERAI.aL
D`V J-,A,(.r~ ~J-,\ ..... . .. õ

~~~ :~.:.~~~ ~~~a ~a .,Ltj~:~~~ ~~i~~~~~~~~''~'~~'~~
a : i.. ,.k .. \ ` Y ~~ .2 ` ~.' .
~' >~~ }a > \ ~ ~~ a ~`~ 3 :NZ.s : ~ ~#~.~ .;~~ ~ .~~~~;

14M."KGROU]NN'D OF 111.1"J.N ~- ENTION
z.., Fidd oflnv:nfion r r , .. . :4.x`. ( ~ ,. ; a 4.t ..` ` E, . ~ ..; =i~ i ~~~
~ i ~,#'i`~.. .F,l~._?~ailk? th._,w:~Ysl~<kE?k~ ~. C'i.~l . ~;.?~.i r~i.~
~~#:1 i~.3{~~.,:e..3.r ~=~;a.~ >z_~ ~~:i3 .`a,:::.L~kE~~?.cst:., kCa, .
3 ,.:a.~~:
i ~

.( { ' ..~' E ~ 2 - ~ ~ 't, t i= :`s';~>., e ..z._?..,.~.~}:L,?_.k~.\,:_.~~t., ia i.?Flx'A:ud {?# .#.. j.. ..-t'~! t? .i{.c.ir..t>~.>{..:~3. ~ 3:A= ~a..
>. .
bei ng iEa:A.ii ~.~>~=..i'~4i wit.i3 ijr, ~ 3f. o-.i... :''EC. ..t. ~..~ # ..i..
.

`i 3,..3.L.. ~:?r ?:. a.i~3~?:[,3f.i,: i, ~'2~.~:?, -...iI~.~
h ;` 3?~>E_tia.'.,3 `~i:dz:`~ .: ::~.~? a~~~' _ ..i, i~~~5z1GyA t~~~..Ei~ ~~isT' = }.Itli:?' <i ~:?,~I.i~': ~2Ei~ :a;. `::.i~r3~:ia.. t~i3F.~ii~ 3.~,:. ~l t~.o ;3 !~ > :
:} i.\
:. {.'=!. .t.a~ .a. `,.., Z ~ ~ . ~. {. ~'i, t.. L f ~~x..e: ~~aa. ~ ~~a'Z.
~i"~~'~~it~i .~tl.=~.3a ?~ , >>.. a ~
aItion 8:z~ the Prio" Aa z aa313. P?=s,'1.\~;aA..:~:
xi~T{a .At.3o.,f t... -,. i~.C ^'~ rt)L ~iC,L. ~ ~r~ ~fi a e e m 2 :3 s i \`=<
3t3.v~~.? 7~ _`~\``t~,3 ,~~: = \ .:?i:.#i C;~?i~`t~ ~ ~?t \ t~E1#Y: :3L, iE
.~i~~~:.3 =ta. : i\~E. `__:ii ~Eax_, ;x .~ .:, over ,i .k~~=,~E2,`,=..?:A~3.S~a3\~'C'iia=~..3r-?s=..'~\'~I:.'.~ c.i;?_EZ~'`,,<~~, #S:_:E,i~~t.l~a~..s~.aa`.~~~\}``:~..':< ?~:Z`\.\'..~:~:a:Z:~.
. ...a?::3...
1251441 . `.. . . . . . . .. . . . . . .. - .
t g j_ i 3.'.:JF' fn `iho\a`\\.'`.kz.... ~.~:~\ a~#~~.;~,`.=~.F>~.i: F:'=i~.ki#a~~~'~~~ ..
,.~;#~:: ~~'}'#~'~::?,3 ~~..3~:3 '+~,'~`Fi:f.~d ~..~:,5; ~.,3~ ~~. .. ._..
~~t3:~'':
...\ e i nd is .,n.:ei: Z. rEw sukbL-,f:Coxtdral bd,t.Z:~,~Ami,.'iE.3y ix ni7.motk\i OnL. L.a.aoi. ,.i.CnFE.: da: e:.idEawL\ \h.iexatne 'Gakd:62f~:,,e7 of a .:zr~=.~r ol: ,cd\.i~\i>.i??!\t\ Z\ ?Y f ~~F Z ~ +'t ,i;:Z~\ ~. ~1 '} ~:~~:iz ? k~' >. .. ~ . . ~.~~ ~ :~.. Z.~~.:L3.
..t. ~:i3 ~~~\ ~i k C= , \. \i~~ \ .~ ~~2i..~.v -ti~>,3. \.
..Zi:~t'Ei.~~...~1.1F~'C;3.. i.. ~.~.z.ta a\ L 'ii , . ~ \=~., \ .

:3:3iqui" i? ha" lhwve k1 dlativG#y loyv t'kÃ:iu}wt~r [.$,e and .3:,.:; Oh ~tb\.\~~.~.~:'3 ~. ?~- ~:~:i\~~a3.ia Wzg1,.,? ...`v\: t..te ii;.isutc.
it:ihmiiiinif i'a:<`...~..... ~ &H,. Z~x`; ..s.~' ....r.rS.3a1o?.
i_k t\: \F aj.;.rk.,i\. the :` ;a,,..A~-.\~ ia tJ >?L ti.'FF {{i-t S
tiZ~~a:.,t ~Z.\z.,.. ;~r\~~.~:~s.j<3 t-.'IZ=Z..~k~~wL.. .
>3.'k...~~~.3avaa~~4~i~=~ew .. . . . . .
i:y>~~. :.~;"= \ +,~ i~Z3L'~L~.. ..3'~3~r.,..~:~iL.\#. ... Y~õ4'i'i":I ~.g s ~.r~L~:L. L?;i;\ ~i\F~ tr>:'33 }3~3 i~ = \~3.~::. ~r ~ L. \rt bk3:La.

\ 4 ~ t\ ~ ~ = ~ c ~ ~ ~ ~ = ~. . . 3 -, ti w T ~ ~:; s~..y i . .r, _ .
bo.ne ty.\iZtxa2y~.\-=c.ftz~i:~s~F.a~~i~LE.;~'~~{~-L,L~~';~.v{E~~~3~r r\:gL.~~\.,_....
\.u.. .a, :.~1.~ I ,. ions .: , l~<it~.~i'1.k. ,~~'~ C.=~:~23,.:~t .,\a: . . . . . . . .

i:i 3, , i:`~, , .\? fliw l,r.z:k >?a .3a:t'vo~, bWo+.F Z..ads ,:.~'.~s.~ ..
'. sp'wa#?^ . T;L. 1 au;iW, 3'n t 2 f { i t.
~::~,.~.,La\~.'iZ. ..ik..... .. .\ a.?\,L.3.a.2#..+J:=:.i..
',,ti..~:;iC,.`^~i.ak.sti~Xauu-j.t#.1 fz d { .2a:,;~. ~.3-F:=:~~.~ J~~~i~\
the ~'+ 1yt\ :Ei \. ~ r~.~_ :.:~.i3 ti\q t#}, ~.~l 3.3~1 and ~ [3.._ ~~3"t.,.4#.ti~'=.i3: .~..C=\.~i.;.
?:-.Z . . . . ` . . i.t,~. z~~ .. Z , . .
t.~.`st: CF3ur's'i:= of tI.'t+1Ie :'-.#fi<.ua.:ir :rui.3agZ lesions arc _ ..
;33 n33;
l.a? F.\.a ~, i`'' R?d` :i.m"?=: it}3 YnI2~tEti'E~. ,+;s1in ~1 t:iSjc`+i~~i ~?~.iFd1, i~`i k I3:;
?'t~za,l g.`~.;i. #..: <M ~,~.; \.
r ;: \=
a,.3 'se .k $4 _ii, ~3\s.~.#ti:1:~2, j ~t LEf Y~FL.~.` L-} .F..~.e.i.~.\. , i~~. the ~ ,: \w. r .~.f.\_La`2# and ~S:.x... _:~k., l..37z'k.:~..\=.[3::. \7.~2,`a a, ti\.i,~.ia~L ,\s \ ck:. =
\~#~_ =, k .,i i t x~_ ,` . ~ ~r'; ':'~:, ~:3~ ;~~\ \~ ~F
;,3 `t,~ t k~$>`'~ ~~~; ~ \ i . , b>. t 1:3nd \.,3. <t: i> ..i~~ k=~.I:F3; ..,~#i:..a>i .,. _ 3.i,1#,~ ~>?~s.f, x '~v . d~ .
a.. ~. .\..I.~.,~;, \<:;>`sct,c3:~t~t.S .

. . iL,... .L~F' w~3 ~~4~.`%s, k6aaL~ti ..~\.,t.:, t.~,',^3.F;.~.k.i ...
sL:~rZ~l~~ F:i E-t;~ .. .

{\. ~~ ~7~~ \
.::\ '~\~c~1~.~~ E.t '3..:i~~~ ~+:=`a~3õ: ~~ai3{w i~Z~~.~Lt than S()~~,i~~~;~3i~z)~,~.sk..3.i:~ :2Z= ~`i^~.2.:. \0.1S i.

. i.~r ~ ~ ` ..~..: : to ,a t?aL ~:ii zt ; i is . x \ z~..=~.`\ # T~ ? . #. ~~~pi~i L i,#. # ,;dt ~ls in (Ih i #::\\
E ~. ~. #
. . 11.6 2 ssti ,e CL~` ~ 3Ã?C 3?a .~~~ ~= .1 ... s.x:
- = a , *, , 4 . ,~ tti :. #`~ t ~~il r#~ R~L>a.~3C:#r sÃ. ~#~`=~ f.l~a ~.h ~~~ s. t~,, i{a , flh .~.. . . ,.
L i}~~~ ~ iy .l in~ th.`[

(,.3.~ L:=#> i ti 3 z t~.L, ,x r 3~an `to~~# i~. a.y a\sE_;
~', Ã,f i%'=~~i#~l\~:~~` ~ ~ ~,~ ~~;:
t~.{~F, ,~, i~. . 1t ;=t;
= a` not : .~~~~f,-,y.~~iÃ.\ ` A ~
.,a' Z.. . i '.a)F2~ ... .
. t ,'t_t,:

:
., ..,., i,id .,, , :.:x.,.ÃF.:'.. : } .:i _ {. f.ec-Ã witi?b.Eol.?g:1c or ,.ci?ul-"I:i t t) 4 .~~ ) q f".#:L"`~: s,,~,~ l 3' . ~";!`s.~#l: s#.: i,.a~3",.t 4a, 2 i .. .,3.~~v a ~, a~:w:~.~Y ~t~z~; .~~.i.~`~.'\\" ,-. . ., õi.~I` Ãx~ r k;-~i'v.-.~'#~~.~Ã~:i d i.` ti ii~p....\;..-.3 . .. r r .. \ ? ~ \ =
~\r.~..~# t:s~> :..=.>>. .ix.3,.~::' :Z,~~i~~~.#i.~a ,.,- : f. t:
a.~~~s':.~.~,.w;.- ..ij \\ : \iLS,. &4i51.l#.t\ 'po. ,~' )?~E\ or cIl?'?..SIiXt;~ tb't g and r \ { \, t, T t ,~{ '' C..{~t.~..~~.~~Y-R 3.G a.:-^r."=.b.t:\ai:f.~t,i:.':~t.\.~.3.#~=s:~iS.~i.=~>~.i t.~,..., i~~`tf~.3~'~:. ~~L ~~k.~~3\F-~~:# \ ~,:~ FF tt?.I~3, )k~, ...x ~Q\ s~, f3#~~.~t}õ sa.s3 ,AS
ch3k..ide #l.,.,ig z.=~`YFUn4)t'#`a#.t3=,at;LiatG: =j: i:L#.i~'~~Ã~:~~ ~
'.ÃÃ.~~,:; r;C.. :~........ ~t..ft;.~t,.ta.i.::~~..\t...a....#.,~~?i:.:~

dQ\`; <, p3~FLet~ .'#u.!'.n.4.#=..., :'s:;3d #.nflE.i#.Fta.f:t F^.3?,=di 2wI's, Jh:.,=a- .t#,;~'iA

y or ri{? Po3eitt2a1 for ;.unt1leS -b,"a?;.ag.

#i 3t_=xL:#~..: \ t~_:Ã?:;
a:h.\?F.~li~ g5 or : .o1;wbi=,honL2Aaf iZo#:.,. S.tto'~.'=i#bg and DF.?:i:.. 1..t3\-f23n..::it.Zin ,Z=d .wix C ,t \ i ::, ii"#.., s.~;S:-.iL. "~.f,~i'~~ie5~ i~~~~ 1 {~,;iF~is :~~#~~ D:3.~i~~~#:~
~.LZ?. .~...`%t~''i.`r'.: .-t.:.'. ~`::
~tc.Ã
, r . r t 3 . 2 , < - .. . \ t z.,#.w :,1..#, .';~~:..~~L~,_i.~.F..Ai;:!'~"Ã.Ã;.'=s'2i#a~lt3\;~ of ~L=>,#:.fFLÃ?Li'..; :~:-#o~ 3t`;r7 .~,..i~lte.a:' : " :#An: :

v..~
Ta \= Z ;.Z C.,i;~.k~? ` . . Es..i.l'~~s'iC~#x\~... , } \:T `ta~.#Y !i:?`.r =a.'~.Ã"~ 'i,.
~3. \: t.. .. n..\:....... . ~..,,: ::3 3 ,.:.-i: ..#.t.
\~:?. k`~ \t~:~:~.~\fi\~ . ,.~'sC~.~.~,i?:~3.{?:~? c~a~:~~
~~Ff~~i'i~=..,ecli..'i~,, 'Ft,'i~:y h.{ve b{,.i..::+:\ .r..i,i? . .....-.
......:2'i.~
~ \.,a t = . 4 ;
., ~`, ~L:' i?'ms,+;.2 nn\)#.?}',' 14J .L:=pa.,, ,oi.t.#-1la'{` dL\ft:?v~:tJ=. . 1: iv patients over `..? 3#. .. o.i~.>.e r . , Y,\ d :.t c ~ ~ t\ .
.~,~~t.a:~~. ~ )..#Ã::=~: .<, 4. . ~;uly .i'~.t ~~.i.:f' a~I..
~;"~`:CT4;.:3..i3.i"#t~ ~Fti=~)~~ti1tlY?~a 5.~..s;~s:~,~. ,~ k =siS:.l;3t:i~
~..e>'2t.., )b:l::
2 $;4~:. i ,n:. a#sZ?b+ .i t?:'>;ik? ..:?, v0'3 ..I:, b<iz.i`h...,','s,3..i:
; a ..,. te.~:i: i.,..J~.,.::i.= 2.:L.:?i ,~3. a\:`:?~ kaorf: i#..:= repw#.i.x :=.~Zi':
.,~ . . . ,.. .
à .I#,t~-t~w..#.\? :#is,. Z~.~:~, ~t ,: tà 3i? ..~3#~d#,1Ã'. ~?eiF~ {~ -.:<.iE?l~~G ~ 3>?\-F:l~i;=~ o-~# ;:i~taC?, ,~':' 3õ a :'~. ;+ t:~.:.~
t~i. ~~,.... ~'#.~t? .i?#::x:a~ , :;i3is., i?i.~:3i~:i#~~<;: i~,. r{,=~~1~, ~.:~.iv. ~ ~ ~ i #`< _Ã t:. ~".?:at3~ . . . . .? `:'ix " ;~`
,.w~..C5..`=U13.#}r u'.`.C#.n th\rcqt.c..#rt.3fwef2-,-~`?.:.3i. ........,....
,.i~~...
``#
to} ..i t# j .... > ~ .,. .t. ..~ ~< # ~ tl ~.. k ~s. ~.3#.t, \ ~ ~~~ :` t l~~t', : J'Flu" , ~\.)L ~`i.~l,ri. k= ~-7 ..<'~ ~~Z'~' . ~.~~~;. ~~Z~~ : ~~~ ,#Ã~fi,:t~ ~SÃ=x?t~.,=~ ,~,t)~. ~

= \ Z .. . ..i Yl. .Y.iY Y tY~i .
r..\2 . .{~2?\y c~~"'rf: a DL4','. 2F~t'~.wt.-=d ~~r3,\b of ;` t:##
.~r\,=L#~i#r ,.~Ã't#~n s:~. .:t\`
\ ..
, i?

,\.

_ :).`: L~>i:~ ; ~ q~.L f ,G,~ .\ `~ ~ \ , k >
-,: ~ { C t~.r t ." a~G ~t: ~. ~t \r Q,F~:.~ .`2.=`~. a F 3=,# ~~: ~.
~ . ..- . Z. . . . . ~ .., ~ = F.S
w= ara.~ a 5\Z-r 2= =a ~ :.F
~l~2F~'z~l:f_ $ . tr~; ~a t~~~ (tir`5 22 x:?.? t r=\ K a~~:.\
... ,. ~ ~:-t~~: FFa.. 3i.:

i I. . =?ap i.3s .f d. _ vF = e t`:a'ft:Fzq~4 I- 3..;q 4\".a3, flFt.=,... ~
=.=~a ..

i?a#`2<:`:#.Ct, ikz."a=7 <bi {;[nhlm>. ay\# ..s:,St.d' to `..a3 C 1 Fibrin t."~ F:\ in F~...Ft=~::~ . ..?.. act as a ;:aL i=~~ ~~~x~i.~~
bi~.~r'~i.~Jl. 1 Zr.luo, i.r<'f t. si:, :Fl. =he t'.ti~ = ` of 1..3.c. I:s~u`?
111 i:1 ~t t~ ~ ~ =r~ \'Q i-f`i plate and { Y<~~c~rtfr..? ;-2 ~'w \ a ~" - =Y ~X~.~. ~
. \ti.
.`:. t.sS~ ..,3.~xt,#t a>t. .~i~. Z ~:,. #..t~.2 3., , t_.Ã~c ?.`s;:t.t?z. has à ~ w ,.~#~...s3 ..`St...~..5r., r.t~3:.=. ~;:;

;iX = ,~.{ ~'? := ~ . r ?. .z.2 . .. ~7 t~ ` i: t r`` :.= 2 a r"~S \; ' 3=== ~
.. = 2 .
._.,.,,< Zs,2.F::,:~ . \={~i~. \ ~.~ - .1 ?aF`#_ii<S. ~ ~i i . .:3: .-# ) at=.-.i.,~~~z, F#.~t.~F ~3i':= s.~.C. .~. Ã,.#~; ~:~> ~ w,F:3a3:? Z?
\b.:;~...#.Z.:.:tl , o, v T
of t~~~ÃF~:e.t~.4 and ~.~#.4?sL' \?.~'t. mt, 2 c ~a;e=2J.1t< .fF ?:~ev 3~~ :~a ,\. ^ F.,i3t~ ' \ ~.~. t= 2'~ 2 =~~~~"t~, ?~F#.., ~:~ i ~ =...~ tT= ~'``\ 2 `
2~~ F 4 ~2~=-.~~2s3.{`.:4 :1~
4.3sf.=. ,,e.. .~~'i,,.Fa.~ a..ta m.:<3:., s..3,U~Z a~.. i~. i.F`~-3~'~
xA~4..?',:^ #.1.i.\.~.,.:~: ~. .,.. G,\~..~.-:kC~ ~.\2,;i:,tSt,F..,->.,32.i s.t:..~, 2,., : ~..? :? ~~x= .=.F., di.ttF#:3F,w v=ltf tht:r FÃ i:_[3pFf3Fs':'s jfri#1:t i?a y.`sf v -.~ \\#,3~?Y:.F ~3 ~':2 y } = f i~;.
Atu. \v a: {t 3 .Fio.~i\ = } 2 ~, ~~13'i#. ::E., ~Y . ; ...#:, dee.L.ssi 1~i#~-~~~. t ~ 3:. F
.'~?xtFL:.=t;'\ -:.-x\. t~.,%~~ : ,~.~\ 3,\>L. \ ~t~:3 ~. '~ . .,i~4.F ~ ~..~.
~f~~\i.~,.` ~~4 r.~~ .~:= = , ,. Fi.,:~..i . , .#.taF'f.
a:.f,..k>de .hL. ~wC2.. af.F`o3:f";dr..F.m's t,F. mag4 tsz i ~
d C,.t#::1~'af #F ,. t\~ ?l.t ::~
:~~a?\.. :::s= F. =:#'F=.. .: : Z>?t~.':~'. I,;. :~.`t#.~:k~tl 3.1'1 phÃ.i:=4t the F~=t~~a.F~=F~i=~?: of , . .
-r:a ~.., ,. . : .'~ .:.. . . -, . ;t X
? .,. t ~FCt~~:C'~F~i. ~ x,, f2 :.. t } 3 r 2~..Ø.. .\3,~. <x.x.,..,_.. , , :~..,.~. . ,. \f3\F. f3t .. x A . .~.. .1' ~.za,.. ~,. .~i.:3t.at.\2 :4 of ~ 3 Si:>.. . ua2.\..al +.. = . 3 i tit t.!` ~F F S}2~.k ~?~,s~:~~~Li\>~'Gr .F-JS~~
:~.i- ~3 ~ . Y S~=
af \. wid \.F #.lLfial." o.r'S.Fw~4~F .1cC2l boles Fn the ,i,3., , . ?- ,..
i~=.4"~.:3J2\~ W..<d, 2YF,?M btwC.

=.Ã ht ., # .>,: s ... , ,.,,ai:d wFth a:3.uOogr#?:Es i d,:#:ida.iC:4E.3 pl?.Ff?s .:2.::d boA3t, sx:: ~a FLa?,~, ..;~:
X '#~=
.. .. ~~i;
o ~3 X~ ~r i ~,i~ig`Ri #.~i: _.~r~='4.st~=Z .t ~ft1:~=# 'iCi ~ R~=1.~: t r 3 '#F = . ..\.s.2 F

2`';F2`\~i~z_~.~.= . :a?: t.\~ ..,mi >. .=. ~y~~~~ F..ti.~~,F~~L.~~::~~:, shown in. 116f..Fr A:c ~ F~=fii::~~. 2\-+.; . \~l .. ..... .~.-. ,,:?
i:i.~-`=~ .2~L~~ .L. ~' Z ..,.. t..~.~`:~=aL>t3õ`.x' .=,::~?i_? ,, t~~. :
~,.I~.?`- ~?.~ 1.2n":~x=,.ffec.x3:.3FtC~F.~~-~. Y?~~~.... ~:~ ri t.. .~3 ~.
:.i.i. . ..t~.s`~
.n ...F?'LG and ifllr3Y \I' ....~
p. x\ a. ~a.Fi i~F~a#;( a"'1'~`.;~F~. ~"LF:F~aai~?.3. ..a=t~.~'t?!\ ,C, ...wt been ,?tf3ni.d, ~=,i:1;i..lC`~`~:õ~F,.c.#,~ =:=:~#.'it:is'.31}?:t3Ft.=1-:~':'~i ?\ . :co.. `~:#.F\.e.e,df,~i,~f3.,~`. ,~.~5 F.#.i:'>' : ..
f'~ ; ~:~=~ ~~ ~ a ~t; ~~~~f e z : 'F v~ ~i~~i Gz.t.t,,.:: .. F :.~s?. # 8a. ::i3, #'ai3. ~ : . ~>~~_ i~~ ~~f,.3:~:fF
:sl':':~,.Fsf~. .- L}.i ,.i., ( rT - ., ~,s;f#..,,c td. ~. =~.\. +:
P..>..#.ia..:S t,:, ,'#~

.3xc~.# ~ i ~'' \. the ~ ._,tF:~~i~#" i33~Fi~ r= = and 2 ! ~ = X
,s{. .... ... ?a s,.,-::` , .. :.~,G . sites t~iii`iiEY 2 <:.I:?: >;:~~2 2.f#t~ci~ ~:vr.:#.
,E?3F:~~.~ ~.\ . ~:`>i=.z >~i.?? 3ir~a>t...~ \}a.
or F n.s 1f:'1; 2 =:..Fi.#.i~tiZ~~`:F~ 2.F~i?~'. T.f'{. . f1'{
., #.\...#.: . 3..' `uto;~3v,`.ats f =: a#`aeis the ~~.'CsG'= of ::is c~appr't%Flsh '"Yo, ..F\.+:ln ":+. i,~ o. F?t y .`.tt #.3, Ã= : k,3.

~?::a\.: \mi ~.~ ,> ,E..>.3a.t:wt> a.J ~. a#i , c~' ., ~ ~r`, . a+,: e ) of t=,~7 , Ã~~~
i#.F ?:. .., . .~C?#~E~~3# Z .Fi .i~i>:,,t3 to th\: ;:-t =.\-\:ti,t . .:G.: .
.3 :~, ,; . ..., r _ , . : .,., \.tat..'~ >S.
\~x ii. 2~i:F#t3~Z., t~ !1,}Ã.~~~ c.#.~t{t _ ,,. w..#i`.l:~
. . .. . x < .~,.~ k` 2 ~ T. 7~~. x .~ }. ~ Z = \ . . ~ ;: ~> ~<}.< S ,: . .
o< ~. = ~ ;

\ e .. ti ~i r o R=~k ~.; ~ ,r^. ~,~ N i ..~ =d ~ i v<f ~3 a .. r?: #ta.#: . Za.. :L. . J.Ex c3.c ~'i#? L ` f3. .,3 \f4lll~.e#~.sa. i 3:~c..= t~.a, ata. .. .~.:.t r.,_.t.,.
t; '~.~~,~.,a.~: ~}.. r ~,,Ã3 #.. ~I L;3 ~k ~ j#.~Ã~f ~ -~ .~. jr~~~<#.\:n't,.
of #l,3<. graft 2 "~ t \ f<.'~~ =.L,~.. `t r" , v2~F ~ ..>.ir`.
,-~.t ~<2.,`~ : i, , ~ ,L,' ~~Z:' .ti to ~.~Z~~ >A,.2 .

i.=mn . . =.s .m, ?im btohZ topmp xt-_ :C3grans ED aÃ,y .t#.l tt. .. Aa , .aÃ;
4 de4e1.as t ..kW
, ~ A al..~:2 t ~ii~ ~, ~ ~~ t.:: z.. `~`.3#._.. ro3, I:~ L , (E{.~ ..3~:~'?
exp3 .. ~ L ~,]:
. 1 x 31Z.~ i. ;tR- L ~~ i ; 2- t.~f ia li ~) x~.a.~~.ts s'2 ^~. ~ ~~ 5~ .. 5.: ~tit,:'~:~. i~:.~i, 3-; + ,- #~:~#~.: \.
p~#~ ,~Ã.:#.~ ,~ Za} ii.#~? of ?~Ã~ ~f~'f:.~f ~. 5 1,~~.~,.~. 23ti r~F to t~~i. ~~'~: , t t `t t 2\ ~#_. Z t: i}~

Z.i~~: , <s:;`l:.~.'~ #C _ e , c:a ~'! :3.icF.7. .``#, : ~%~l,:~.=, ~:~:2 wZ~
i ~:t ~,ti et.~ti>3~?t.a..i~C= . 1S ...3 ,. . iõ +?.~C's~:i3i~L Ãs z ~` . .
.i3~' i. F_,i:\:c.;i ~.y.
donor ms: ,. &laind stara?t: i . ih ,..F,..# ,.,.^'.+`ue. .:fflR3t}na%'t.;1 `):the iik ofmannune.~~io\po.~%\,.. ~.ir{:i,`.\-t..\o _.,~~t__..iKl..~t=.L ~a:
,~ . . . .. . .`~ t!.# . 2 = Ft.~l.! ~~Y{s.~B=~~E.lQ~ <~ ~ ¾ y'~`2' = a ' C
~'k ~L. ^'''` ~ .rY. . =- .._ -: t x ~i.. r . . . . .. ~.
..f.~.....> .
x: ~t ,~'.(!:a i 3+.'Z.. .i.':... .{-. .~-, . ..}. a ,n$.a, } t= z,;; ~ =< 3 i~ a i t~ <<
c'{; :#.,3t# L < .: i of 501i li`r , ~ 1 >.! <~.',4 i;k#" iõt:ks lw;?;_ .
:: 2 i s :
yk\
i.~.:.~.. t.. ~s, 'k'c . ...:<.t~...\L=\a~ai _E ~~:~~ ~l)\`A~#r,.i,t.#.`4,:f41 ~L.~3..L.:.
~.,,C.~?~.~:#.3#~~ ~3 -~. .. f. a~3 ~

r c5'r,+2 r =~~E ~'~ ~ r ~ ~ ~ t ,Ly:, ~ . 2~7~~ t ~~ Y L ~ ::t , t l r tA{
~~~ ~~2.~ :L~
L:
.?r.. inq)At,,r.w4Ai~~~Ã r`,b{..;$' ..E:`:x'.,1pk,j~ t3f:~i3t..3 ,'':ia33t~~
='t.~i_~ ,.,. ..T. :R.,. . a. ;'4:a.:Ã;2b.-2 2,. 9RY t~~ '~'.~= ii. ~:~L~,~~tyt,z.fi ' .:a= tS 2 . t.~ ~Ft~` ~ ~t 2 `i .
;?ay . ~~~
t~,',,. 2 .ied \r ...
:~~E4 v#: 21, '~$ ..~,i,~,.22~L~t t.'~~ ;,..L, ~=t):~.~3~ i .,.1.., .a L<., #t...>: , <:
t-q?z., . ~ z, .3 ~= ; >,mn et3 it ~ t .. a t:,.2.a.,.>:> iS \ I ..a;, r~l1F i~ ~:, .: Z3 c; i? I e:xz o <:a . 3A {)3Yc i ; ,.?

21. 2COO doctoon a 4 < H.#.i.:.dmi ghdi wth a#::: i.t-iit.a.ii.3a bt>(ly 'a-"'>_. =. ~:.

I~,J \ . . . \ aJ.C.l>i2t. = 6 ?\ 8<\ , Y +..1 <3.<e d J u n c 4.= y.=!0 2 d if \.Z.J.e d kmx ard a N_! \. S.>-.,\ i Q, at ~~~~.~2 t .2"==, ~~ .k ri~~ti~.wt '~
> ool. p,z# an..tnwrni:t.f2b:i.fugh ~~ i'!' kln,= ~v '~ 3 ~. ~, ti do..
tofs..~` ~ ~. t~' 3Lr to .<: S hold ., ..~..~,.,., z .i~. ~ =3L. ..=a , }iiwS.#~~ ~-.. . :.~~'t ~\ . ~ ~2. ?,.,-i ~ i. ~~.~=~t ~ ~
.,,...~.~~i',.;.~~C~;. ~L it~ ::.~ ~L.,-s kf~3 ._.,.~. ~. . .. . , .'?~3s.ta.~., #.,.. a . ..:.~k - :.3.:

014a.i#m..: ..,l , .. twd,h ,., th:l`~5u\j:h . ,>Ã[ bo1e d:~Fi'_iei.~.a,i_F#:3t'.#: t: r bt3E1o I,,)W#,\ Plu.t3,.3e2 `t Yil \5 :.s~,,ued Apwvl 30, 2002 an ?2.r3.pYa.~a \3}\.
\io\ y of s2\ Z = i`~~ :. 2 t i ;P i a.i 2 tõ ~` .= i ~;..
;.t a,,#i~~:. ~.e.,, ,,3..w5,`Ã:, ,.I?ta. ~:;t3: . :3 ~<3c~t, t'~~t~ir#w'~La~A..ti.#Ã tL>:lt,i~ t2 .. = .t~\-~:. 113 :A,ap\ o i_Yows or a ph i' }. of a. =l:Ãiti ..ic.. ,.s. S..t...~. it .

N 1:n..,b\I 6. t` .r , :.s~~aA{: ?:ptt.`..:Yb\7 ...5.2 0 0 .1 -v?rfiut,h:i:,i;.tt::: . . ft3:? k3a{; b Z{. {l.Oto?. ?
o'f \t.i...t~..~.s~5\..
\'P~2*~~~ > c~, r=t ~~ s i? t3~:3t, ft7::~~#.slf [~. L~~ti.~Ã~t~i~::#.~ ,{ *', y ~.a ^ ~. ;~~,` .~,:w !4=ita .~ .#.:.~:ai }~ \ Z fl%
~~it3 .\, x.:la:i..i:~ ~~ 'f`~~~:= ~. ~t:. C~i` .x~ .. . ia ~'~

H3w t:?:1'i)s3gh d.?r. 4`4t.tl33m3?lmuC?3 L~.`. htta a ai.w,;~:ii2"..

.:i3 o.,i't. ~: ~ ?_ fl..ib}, =i,' .t i 7~ ~:ft~~t3~r f~~F a; ..,,z.i3. _='\
s. }` <Zt; . ~>.. . .. `' t?:

' _ Y i , .= r t q . 3't : ... . . and a ~ ~ \ ~?
~:.3t .. . Z ..i". ,.. .,..,'~ ,3,i,Yh:d.~ ~?t?~~1 ~. tle:Es.. <:i ){.\\, i )''..~~b ..:2:i_h i}Z-~~;r.' ..

~Z{: : i`.c 3 ?..p i ~I h; v C f } .. L. d f f.T r ~~. a ?~ i3 ` t ?. t" ~.
r : I .~.~; ~\ .#: Z. C?~~ i~
=~ ~ .3~.F~i. r t i'.,:3:~, t, opoik v#2.'t....gE: a.`e<.:;3 iA#:e to nature f3f tx3e 1ho'#:ao vv..#ii;h, L
aC3:~~~ IN'w.3i t'.~,.3~~=~:i..

.o im 2,\ :vnpxa..im: As5,i.'.e (Tgxttt", :\ e\ i~ 2 ? ;: ; :9 c Z :, # t 3f~~ ,t.. \ ~' 2~: ` `r.. , . ~Z. =31~`;..
.. ?~. >.._~ t.... . .Ãi . ..2..\ :i3 ,.E aF?'ts. U.S. ~. >.~~.e=:13e ?~a1ld~..3.~=3i.2 . ~ ~, . ~Fat.;.. .vi. %z7.. s ffi\ x.x.2,fcx.. s, 2*: it2 3i.'#.`^ ai s#.cu.ua~ k..%23.lflr V;Z: f aiZi.=6.'RZ3ui 'f:fonS',~Zt31?~:.z =~..<< .}:t33 ri. t.f,:.:):`.i...'~~:
i~`'.. ,Z\=. r...r..
~ :

i`a 3n.. :;:ÃC, i: . ,a.. . Y\\i3p.Z: and inclà .e; \.i`t?T..ldin WW or fta .
Ca: :: ~....>....
f~ Z Z .
t 2 \ ~ i Z< = = Z .,` z;' \}Ã~3#;= ~,"~.. > <, ;3i:, t, t~Z.i-. :_~;t . the r. Zr. ;G. . ; i. ? 2 , . ,~}
3;.~ <i..~~~.~.t, ..~ti.. ,~~a3:i~ ;>~..i_ I.,. ~.

;:~~r .~ ~ ~.~ . Z.{ . .. ...... `:
Ab. .a.fi }3. `.~'' : : ~ t:...,c~t:,~d .~'t ~ :)n t>.i- i:' xii3Z , i. 2; the = - x~wk` 6_.sia ~ [s.i3L=~ : x.~ , ~=~.:t~w 3~3 ..xt, %.3 ~
;o-i.'.~.....~.~iFt.i~\.=cx'`..;.~~?:~1..-~.... i.~~.
..t~.~+.:~'{:~,C3..i3r:^f.l:b~1. =2.1#:-.n >.'2bw3.i tfri#.~~`t "'riA?llt:r, .~3.:::3iii..

. ~ . . .. .. . . y.;c . .. >.: ~.. ,.::3n..e..;i`213 b#':3m . .Zei ~\ 3~:
then x`y#ti~?'t.~~ 1~1.i3 t~1 L fÃ-~:t 1 e{.i hi .ITa. ~ ;`i= <: . ~a a ~=t~. t Y .~t ..t \vi:.;"F
<`i``.i. ,`ik~e: 3i..g boÃ,v. ;.z.
~ s,.` ~. .~~:' .}~ be a] a } ~,~3~it~ 3.t~... r ~ . ` ~ v I3 St` ~ #'4;~a fi +L I2`;{' a No.og.}:.ad ` wc~. is.IN palIi mv,i are ke~3'i ~i~33a ~Z3',~t 3f~ ~ . # ? = v:
~: #i~.<<?~^.v .. 3 :i =`.::?i3ttFmou.a ; 4s_ S 3cwFJ each nIt`~t'f' ll,;~:=~.f3<?#.;: i, ? `~ ifa r3 3õ~, ~
r.

Z ~~i~= \ ~.} {: .i;= t 3 ; ~' ~ ~ .t } a ; t E
2. a A~ r~?i-=w33 i:.li~ .v 14~~ 3 d:1~ 3ai.i3.~ F= >.. L ~;{:3i.~4. i4 w~
L:. .aE. a#`Z'.2... 33..3:
v ..r3o2r33L..'{ty .}.rx.x.,~?.~>.~3.~x,~?.~ i} ,,.r.h.f.-Ii4.*':~~t\?
i~..ti...:at\y?zIi.::p 5stynm.Ih~,d i.. "`..:.:>..2..._~i.::.3.~?i;,~'i~._~.'.r;~ iy\uL.,d"lpt! 30 50{?:.
{.SisL:.lf,`i\L.saipFu~

: ii?s:...~3i i2.G :.it3~? i33L'z#Ei? c~~li ~.,ix#fivS't }1L . d_ii \ #~::i.t C?., t.?t_ i_.2 3.::t>~ t ~x:: h - :i;:
v` a t?f :.xio t h:i?:.

N`~:~~ai:' ~.~~. T?~~.. IN'~ ~~~TIOTN

:`I. .3...I:: 2?. i 92.,a huplau3t E< oF ` nii a vw~v~~ puea,.k : :~,i? a,..l .;t?.I#i~.
w:i bi.?~,~.~. base 3?3.::IF?.?iai ,3d a,' l: e;_ `;<7;.. `t in a ~.~ El,~ t.3`i. ~:r.is.~. . .. ~;.,..~ ' ~ < ~ i :
22Z~2 .L:rtis. Z ;.
;:~.~f. `E ~ 2., ~ ~..3:. . =~õ= 2~:~ . .c..;~~ ~#I .;t~ 3 %. iZ,Z.i ..t.
<.13. :i3. e ``'~~ ~r r.: 3 3`~, r i.~. .r s ,{..`. Z.? lZõ~~~ 1. , Zi '~
.:c:i...2>..Zi.~. < 3..i . . . .... . . #...i . ' t?. '..t S .~ ~{ ..r:Ã. ., x i. . . ... ..<. . 4= .._ . . . . . .. ,.., . r. . t. l.>,. ,.. a.. .. , - r' -,}:fr 32 .. =~k 7 l..~i3.~t.~ 1 t`r` 3 G {<;..i.zs y. ~ j .i ~ 9 i k C4. . 7 R3 a-Z\ i C.. . ro ....;
~-i:.L.4\; ~t:~.. :.iaat..,\. Cf tb~#it i: ~3~..~i..=~'.{.:,F ~x a . .~ : ~. l ~. -.~a, .~::2.2i ~.a~..

`~
... i.~
.z~.,~. T{ to ~ tt _> ..~..a..: \-z,iJ. .t ,a ~~~~`~~.=:L.=Z,~. ~#'~ ~Y~.. . 0 '#;) ~ k t:ia~.~~,t '~ c f..~.
.. -f1. #~34~~.C~. ...he oJi~ a a~~<2~~ .{.~ `t.

2;{}i`,,~.:. .~ bore w3lli ;t in .. sca:'ts ,.he b#nd bore aE;:> has a i~I,a?;i _I ity .
~.3;?#;~ S~.~tL?3 .: na +;:a~a. >,.i to :i. cy3#.i#.dI+a:ca3. bone base i3.#l..mbLr. >3 =i a li f;..\> bF:f rZ~i~ ¾g ~ ~Z \ >.3"C-~
''~"~.i~~`..+k~a~.{,.iV~~~.~~~,+`~.~ ii~at ~Zf..~~. i7::~<~ ?~~z?~- . .'~1 =`
_: ~.ri#+?~}i)Yz ~.~~. ..3.~... ?>.::t. .~~~3eA\3.:~ ~ ~. Z..L`f:F:~4. r ~~: ...5,.#.' .., . >,-.:.
:?z~..~z i~~

:z:, ni..i bore. Tit. :;,{se s:Ldit!_L.+ i: fthZ Lap body Z}vezizS:'.? f,. v;.
\. : ~e 0 ; Ai 2:,:;:
:~
.`.~:`i~'t~ :t;.\.t..
:? ... >.i.m:~'Zbt?Y' .,.. :..ia... bt?w and t.'}~it= fo;?e ine's'1I.ber f#'i.i..l. ~~~~ , ~, , ~ Z, ~
t . : ~f :L:i? `.. ;.; II~a~ .ÃJ.#I ~.~~>l::`~ ~,?~;aizt~ f:?t?>e ~?\.~.l f: . ?f 1 r~
s'v j"'E\- ~~i. E `x:. :~,.~..`~:ti .i#a~:?4 i`':' zS: , . ~
>. .
q t .
.=Lf~>:?~.~;.:3..t i.:>..~i\2~..> .,? zs~4a~:~:$*\.~^... ;~~e...,~:y~y~
'~:c~? i~:e,.-~.;Eit.,.= or ~~t~i#v' i..>.si5.~.~ axamM, ' `. \,~ .t s > ~, < Z , = r.=2 \if 2 - E r ..~.,w::, :~i t :,:.s.2.:.
~.;z.ft~.P ~.3~,f: a; 3~: ~~~?~.~~'?Ia^i ~~~.. <~~~~a.alai?.~ i.~~ .~ ~':.:
~.' t.(y o;

,}~5.J~r ,} e~,] { a}(~= , =~{t c[ i }{ y } -~;, -4 i} z )oM~Z.#.}L, 2~=a } h'A=
X=:=hi~i~<~yv. f [~ (} } ; ~h:.~.t\+\~~;-`iX }.Z1Y~T.S. EZ ,j-:t.:2 ,(`:.i..\.1~,l2e\.~.2.~r.(2 ; Y;._7-i.vll.i.}i.~E~Si.E... .
E~..E}#..{.[AF:.~\#L.=[ }.t #T \2 _ ~
1601, tFl` 1t M410, ~.~~.NG# PDO`F~ llq-3n 3.:.#m'~~: .~.Fl!~r;l:~#..i., k.~:", ci.F........ 4 4~ `T\~:{,a.t'i~~ ,L,r ~z-..
,a. , .~C:., a < ~.,.

.Y.,.~.~.n$.i r" ~ Ri.t\i2 ~~~Z:=i,~.\ ,,.: ... . , } \ 3 L.ti-~. ~.=iiF f~ p .' ~X a i ~.~i . ~i~~ \ .=~r :~Z#~;'G. ~~..::< C,~e 7 't,3,.f ~>:. i" ..X.. .
.~#.i.,i.:.
fran"":.i:~rZZ~i ' 3:Ii?~v f:~l ~ila:f.i3r ~.~, ::i~~t.~~\i;k,n . .i t\ ,f3.
.Yfi:
=

f':C woc-t t> 5.,?ro'\ zF. :ffit Z:. ~ ~=?e.a.\.lh..=i-Ci-or#vCd g:fjwtii fauw', 3.l-ls:iir.w f~i::el~id hki3:tiz and p-m .-by;t?il> f#itrr.#ol-w rt:iri3.c:.d. pcp dL ow .~.it , . ... .u~.'~, ;t ..S . :i 0A i.,O" ?a thk".'= .n; sw`.iat3w.3 td5 pr{'3vid..= 23.i1 aflogIa:ft iF.XIp. .it ?; co m?1#;; ;#. `#aL ?L:iL.e .t..aa n3. . > o: 3 ..i3d 1T ? po~,~'Ip(?Tle or ad lt.vIi:i.e t.?.. 1...\.ai 3Y C
...>#.#: ..Z ph:.# ...... .>...
it à .d; , . aL:,:i;lf the .:;Y.., f:?,on to Provndt>~~can:I;a t b"la=
kuri:;z:?iah t: >` Ã.=Ã:Z pE: .. .+
q `,..~ ( ) , q)}}_( }( ..i} f.. \.~i<~.1\ \ \i.f.i.Z \1::\ f.i#:w~L\~..~# I~.~c.} [ n ii~:<

f i \ . . .~
:t `' ?Y-..a. ...i.,.?~~.:{.. object of ~`i.E.;f" #.l:k' .....i{3I;, to pro,`iLse, :..[i.

~ t ~~~. ., .:~aV:.a..-. an L~,~'~~'~~+..v of t~iL, #.t.~'~''~..~#~~#i`;~ to ~}'i'.~;3'v4` :3.~# ail~?`;# :~.~. :i.i,,`f.?.i ~~#~~,,C~<r7tarf::;
~l=>k`=a.L.x.:~.
<:ip`}.. .,-.... ., i i'#c:....>..i xmd" I:.d.i t.t :Ã=:;i..~ ~.ht4Ãz~.

is yet w..3.`eh,. 2Zk~iL.{,tof ..~aL: ti~pmR. ir'#.~~::~ i.#.ii af.:t\graft.n.ir aaw .:~.a.
r.owdh ofiz2 2.:;Ã.i ua, z 3.l.
~
* i'.#.i. ~~ a z~i~ \>ii.a:t.
~ ";sn.a3 \. 3l~~ r +" p~ E' } ~ L
:~.i . '~\.4..~i i. #{.=~#.~x~$.~~z:i#~~ ~~.~.)';`~~4i!'.fl~:~ a L.=rat.~>z.=\>.,l.ia\ E.~... ~L?..~r,=~+ . . ' . .. ,.t~,iaf~.>.:.
t~ Y

; i.

:> c ~. c~ c~ r,+ ,r~ i t =
'~t~ : ,. :. . ~:.. . v_.~^. \.,, \.k ~8i A,s,. is~~.....,~``,e,e, i.ag~t ~Zra.F ~i aS ~i~ >+.:f . 3..<kt,.~~L,`e .:,,.
.: \.~.z~ .-. e#.\b `p.;Li2l Z\3# ,. ; .... .. .. ,.d , se tt:.~ae?Il I.õ:'~ <.oi1taI,:I'iA in the <i i:ti t.>ta:':

., L.~ ..#.2>.#.'t~r Jtitt ~a'2.~y\.a- ~H:`~.

OFTHE DRAW~NGS

.atoniy Ctiif akt?t''.'"~~~rutt :2 . ~ia.i. . . .. ,. . . . .f .

2 } ` s.liiW.: 4t h matIo mzisali'pksl3 a~s knok~tii if 2?. ~._ .... iFi.
. . ' ,` \i:~ r3 . .~#: : 'E2,'it?ded pf.i's'pecdI4e. VÃL`w 13fitla'.:ÃmLa a,::..~Y:.~~;~ ' `c ~ r5I ~ 'iti3 ., ~ 1 s_ s ctt:a:s~.'~ L:.a$,. ~ 2 = !-= ~t \. Yi .
, , a lZ~;, ~,'~~~~#2 t E~:~Z r.~#:ci i~i ~ ~ .i; = ~t24~,i ..~li ~.Z.,.:.~..
. L. }. 21ial~i::
E c r 3 ~ ~i!
;-~-~

.F a;: .. o 5 Am\ a, Wo c1eE ati.F,3n i iev)" C f ti: two ploe r`

i w ,v ES ,s e;t.i 3.:.,;#`r Z #e% E t3' t p:F14Ce ci3#1su:c: t3>. ?' gi ne 4 z~ams~:>:;, 9(r' t.i::e i.,,.>?d ,:[z.F>' p,tZ >õS ; . Ci ;he ... Z 3mL3m..

E t .., u w . . \ a ;,;~ aL,, # ` '.r, ,i ; #~ L. S~%. ~ :~ t..'{ ~L,Ii ~ ~ e C . i 2 ..~. 4 L i:: L~~ c L. I . . Y Li^ L \2a , ~: . ~ t r 2.i >;: z . ~ i t ~ , ~,:~.
:.i . ,` Y ~..%L:= <':` C 2 ..~ . 1 ~=.} i. . t~. ~...>2. =!. ,..i:i:ap ~v S4 .. v:5.w .3f thL' C41'.~ I.TiCimik.3er of the eam0:; ,,);.~k co,..rm Figu t' [>2 # , .. 0:1 . ;\.!>t?.it?'.; Lt. 81 .it,:_.

f a?k` . i~ a,s a side ...i.:~~.:di.r.i ?i'w of the r7 :.3.1b:.I` of t:} . ..
ms#a.a<.i :. f f ? 2,: . ..
DESCRIPTION Of" TIM, ~NVEN"~IONN

110 Ow to rn:, ~...3.i~.: o:;
i?.ial.1iil:abl. ,.hc ss.3r v.v3;?1;::itt' of ~~ ai s 2. ~ ... .? ` ~ `
i,.L.,Ã~;
~
. :~. ~ E 2.: ~~. .~at.t.}
t {
r ,~2 ..2.~~:~..v`:~.a...
the o'vi.T:..i.F i.uIa2~Fst~` :~T~'~.~ '~a~+: }k.t~''S2~~d ,`= Fl .,: 3:.3:,.
t.. #

rp >y~Z t 2 ) ..i~.~3.~ f~'~#j~~~,.}.t#2. ~> y= ` {.k }:~e ~~.~~.=Z~ ~ y> o~~c ( ~= < ~~~ ~ ~ ~ ~. ~.Z. ..?;rx.~?: TlAW i tW:' ~~._.
'~:f 3 4 4=}`}.~ . '~)`f. }.... k:..~t. }t~.W#~4'?Ia~~M\..:; t ).1.\Z..n~.. i i.4 ~4}.A
v`
L:.l., .. . . i E ) i3bielz :i7.t#v hC'. 13trZ?dud.ed ;.i r }}d'S' i 3 l.t,. I:anis z3:'t g.~]',Og(v} _3:3t3 Awds 2md" t'L.i's: V) ,3m`tit,, tv i6.fl?..?. am denZL:d fto.n ~~~ . ... ~.~i.i.,l~= 'ti.s .xN2Z::.os.tinst#.floT,yt:nL.s:."anf.ii r MEog?ifff aiC. s'.i C~c . .. ~.
Oi\t._:z ~.~i~._ _ ~y . . ; '~ . ..: ,~k~: \\,. t.a.>~ li-:~ .,; Eti ~i:Ls fz`~Et, , ~, z ~.a..( ~` t.. . ? {~'1'27 `! t~~ .. .~ . :: . . ... ?v > t^l' .2 ~'.vi. sT~ 2 ~: )~{~ .}.L. , ~.. . .. i`F: , .a. ,..,,. .. .. ?r~._ . i... -*
.'%ni , zog..:ak 2cfiJr :oZ:s`.H4 o:' ds>i#'ac:N3b.C=h o tg ,lm`~~ .~. o;' < M1 .,..,..?L ,d?,..~I~.',c t1F~`s ;~: a.~;F"ea`~3a.x.F Sa?4Y.irdsa ar1.MllagL
tc~p~#~#' ?.
t~ ~~z.> ... , #.r .:.~Z. . \. , x . x`a~ ~ 4w~.~ =~G:..3?.3~.~,~~}L~?.:~:w=õ

~ :~~~ ` ~ ~~ ~`~ ` ` ~ "~3~3 aD`= ; 3s1#~~.~.~.i.F~S., ~ t~ tt) v 'kZe c ia r=:.=L~:~. ~..,# 2 ~ f''t.
{: ~. i. ~si=..:..t3i.#.. ,.

~'~.F .`Fz=k.~ Lf f,..\..:..`,tt{.~.#'{?S.Z,~..kE~~..~ '. .~~te~l.x k - :#.' #i z-;~,{3`#,~F3~~~ , ?' 2 ,t , <~> k -~ :`t 4,.~? . . . ~ , a ~ r ~õ`~: .S
~#.~ [.a. ~ ,.t.:~..~..=.~ t: .~. .\.:.:.3 ,= F_.3.,#:..., .
. t ~`
FE..:s:t:#.4.;3.#.L ~.?.?,..~; .ka#x.iÃ:.'a. (.,.1;3..,,E..S a ..n'lÃ.%' 1, ~IF:at piC :z , 3. . _ A,.1.t :. l.., .. .. .. ..Ftt 0 ti3e ~A;: ,`~ :>w ,,3 +' t>1,. ,:I~= ~ 3~L~: itr ~:t.#,. `,~ zI
;, _..> ~.:~-'ti .~...: I.FF~.. ~:, ,~:.za #.. F. ., .,.a.. .... ~ i.t~i :f , <-`;< r..
~bs::.l` 1. .t~ .~ ~ ~ f3#.~.{F~F~.:si' t`:....~ :.:? 3 {;?{3i:L, s;i:..,..2-.:... 3s aJ than :Mt} xYAd . :,r.d;...d CAti. :a?. t . .4:#Ã;a Ãs tro;:i#.F land. 1"y p Y I \43il:IMana ~vhi<,~h T^ a}p`C?ngAiki in i,~is?tÃ,:rZ
i'~i#z{'i ant t.,c#.s3-T:= a \Ãah:, ;ti tw1',,~_ i\. .:i\.47Z .... ::. 5:b: I. and m:u3~` al;.io b_ :t== ., . .. > Ina d3t 'L,.3.:\< Hit..l iks.. ;ti . . . . , ak5..fit...x of .he c?.`'.n\.d..3C? aJ Z.a: i.#.,<~~#. L~L..a- .{~. :..,.a.i~..~d ;#l.#.~~t,. k.-l:it~ii#.'~:{M~ x~`~E. .- . ~FS'~. , t3<_,. .. ~r \, v;} ^, r Z ,.t.,.L.'t J , F? F ~r ~:c=
. ,.: :{~... Ã',.e\.:
::h3kõZ'e a x3iJ;' ..\xi=.~i.~..#,\~a.3.Z:=~;5~; 3~:~~c#.~1., ..>E Til3 :~,.io-1.e ' . t ~~..,.; fL,..~.. `~ .i :i.,ta .~...fr~i . ......,. `t ~kC ~ ~;
. . . . ~ '~~~ .~~. 3 . _. .=,..a.a .i~.w~L.~
i~. bon.C:.

110 . !' Af, ~'.L. ~. ~:i:#:{#.{.t.::~S? .:<?.I# 47#.Il . ?f) 3 t# L. F t, ~' I.1 1 whidi :`? . ;d .f.k?,.d :ik, 2?.{a.3,k:t: :>3 a:F+, i3x#~wenoo>3"abeI by a ?Ãn 41 .,e t,a,.

6;:cm :.i.>,..o. .. z i.t".{. U.,: acanf.dlous ~?~E?nL:,andI~ti~7:l~~L=z~i.E~:
`.,: ~ ., 4 } t .... ?t~. s t-t:. ;ko~`.t. ,:.3`i. :tiE.i:.=,~3= i,.''::=t'tE a~~~`=t' L, ~;"'} S..til kt`. L.s:'F.:.L.t .~~~t:,.ti 1 ..:} vv o t:or `> 7:'Zc..d\ :. .
, . . -. aZ.aa ...~ `=.~.-~.~%,Q~. ~:?:` .~.k~:ca,~?.:=' 6.ast " inS:; .{;. :.~ .. t. ~i'"
;,,.} i;oi......Ii m.~ F:.: ,,.il} " cs~t.i iff s .,v "r~. t: ..t: 'k ..
....,.
. .. -.. ~i.i.>.~ . .., _ is ~
} ~
L:C?. ,:\,.~..\.a.#=4::3?3\i\. ,>.?{~= L:fLtit, L~.. tf#.Y ,,., f.~~..'~#.{
: x.". fiF b.?nd b1_itt \ 4s:]=Ft. . ~t~'(ALt.: .??\

36 L the \ a:? ni.s ?..#,.i ` 31 .E l:`~ ~~om?Fi-c. u, f:3f.'.l 24o ~ OF`:' ~~flõ ~3t~ ~1 Ã~= ` ~' r. ..'=`. , k`,._ ~.
~: '~ z.. E,~c. as Crt = _ ;i~ a.
'~
.:i:.F~i.,. .,:\..; .;?.k..uiiv;.,-...iFt`.tihorl)4~a?1 bt`r~Nvtdi`hF4_p3,i:=3.\

`:?a r .e; fz 22 ?>.sLk plad#.?3I fi)rRnasl ' . .ii,.. lb~ s ~. #i' x._ S
.2~~.L.;., { . ~.~ ~ 1, Z ~ = k?~r ~.' !~'#~:t~.:. .e . , . .>2 _. . = } . .. ~
28 she ~~e'.~3.LwiraS.-a b.dk+e abovi', ifiL:'i.?C~tma= ~~.~~#`a.., L:=~,., ,., 3 ~. 2..3 ; t .?Z`~=~ it .?..,.: 2.~ ~~~~~Z=

'-"' 1i1:=. ?#. ~z t az. ?3la:'#.k.d, boi>. 2.3, A. second pa'#..v.dFtS o;.
tb.EoFl4tt g::siI. boE. ..``
cizc?.,k.:=?e 3#., , t _{r.i.: ?d ?.l3t: bEt#'?d. btsle .j_i 1?wa3ki to tho ut.Ã:u;,l al... 3 .?.\. ` .. . . .... +.,.
':

i;=~E.~~..~~LIF~.~#.t~Ã>.w~~'~., ~. .. 3,kw:'~3a~`, .-,; 3..i,.,Eif~..L..-,._. ,~.;43.:.-..
.a ti- `
x,.,~...t2'?.:=s3''.t.=. .i.-.......w. L'\~tw>, ~ ~- ~ 3 S~~F: a i >5R~~21.a ~'] t T .=2r? 1t s~.:~ ,.#.\ ,'fi U ,i) ,,;?
a..'2a?
La:..:m\ ..i } Zax: .S.i .i:. ~~.~ i ... ~.f .'~#1.. ;. ?
.... ...\ ~3.:~f.23~.\ .~f. `4[2if. A1 6.=.

a J..c ?.:: a x t #.'~\ t^+2,=x.,;.?~a Z ~~. tSta#}\ \:~~~s.. }~i ~;2~~~~.., ..`~.~~Ã.. ~ ~ .~~ , y ~~.x,r: i:: ~..{.. ':
:a top >s} 33, t~. s~ 3.: ? 1t and a t. F 3$~4)l~i ~~t#at:' :.l"' J#3.I
f.3x:i, . '`
EÃ.. ~~L3~ ZZ a.:~ ~ . 2 ai5}an ... ..... . ..Yi,,,t_w 2 ~ \7'~ ~.yzf'=ar~[1~\. :}<,. ~t2;5~.:} .~., on L.t~t.`cm2 :,Z,~ a ew:<menul#..?

to t . \ .. . .. . ,. .
#:~ ;~ .: . ..~ . 3 .. } . ~.. .~:` ax` E4' ~?l:if;3, t:i#a'~ I : T,lf I ti ;? ti7 t3 dti.g.,L:. >f a.:zrl'a i.#,.., i:a3.a. ,a.. .i : i #`
~
r~ a i:~:~: #.a~\.a-Ãr~`4:a ~:3`i~.-~r:'-3 .. i.#õ#~Z,t\i#~'~: :t~? ~-.~kõ~~~\.2... a 4. _,;;:;.
~~. ~~~`~ a.i;>. . .:\..:~~Lr,I ~ 5 . .~ -i\ . i. ~ r~~4i {~= . .~ ~ r.#
si.i.t~~.,~i~~ ` , EtE:>? a. :~..~3L,. t . ; ~'s~#. I:t~`t,hà i: = . f:. ....
r,... ~3Ã~,-. =t . .n =k~....i~\ , ~ #x:.s'"

r t . ?i . >x ='+ t..$ . f S7 >i ) Z '~? '`ir;... ~ ~. ` 2 ~ff,t , i 3'~'i r....z.a J. et~.?, Ã~-a`.: iet\-=r:~:,: L~ \ <'i ~:~~~l.i:, ~.
a.z..24, 4y . . t 3.-i..:>.
. of }.F~g [..E~}-L.f j and '~'\, \.~3# i not .~+
?xft:.\~3, a i G t~`'L, b:.~~.~''-`h C~.S ic l~ b3..3.'~~~ 23 "~~:~C3 br 1 i.i.d ..Z. ~-t\.> ~,i-;ut.#.f ... ... , -.... thx:n ,h::t r. C`. .:`..` blind .\.`.t:` t?. The õW.IA. dÃl.i.#Y".i a ,.# :Ã.s, .,.
A.L?.;:#t=:'` gOi`3 i::#E .x:~':ME..?.:i::..' er4,...o.\.2iRE,?:ethelb:.sL o-:i7ti#lbi:r .\d.
#4c.:xv\-:a y4#I#d..''=ia.;3?:t:30 ,:T Fhri_f: ` :-:.:~ a.tnsl.mi:=t to z~..oW the t.ap zl7t:i?:lbin[ 30 in pl<a.: : .tNi;' base. 2. zb4 = ? , a =~ =~'E:. ;a.at, ~`x i ,...,i:.r,22\ly C~ ~>.~#.~1:~~ ~ ~Y v yp r< t~?
vL#~2ai-.i:C': t~ ~\~ ~
#~... . a:i #..: #.~ ~3.~:~~.~.~#:,~.i.\w.:#;:,Z..tilc~c:~ ~. ~i:~e w..Eht;;
.:x ,.
.
?
i:o>w#n less ;_r`ia#': t},',lizi. i :<ly lu;A3.. P.i#; r<% ~ #+: . . r}:'.
.. ~t ~. ~ tC~` . ` .~ 3~t : and has a length t~ t~ +.:~. ~1.... i to j.~rk~;~5s E~.1..:3 : the .E.. :::~,>.i r.:.{`.,}, \..t~~t~
> a.4..,at. , . ..\...:4; > _?:[~ . t3sta ., Y` .i: ..t~,,. ` \ .. z~
~,~,..E?~:-.~
i;
__._= .~:#r..3?\,:t.: \?.:s,ifÃ.~~..-4:~Ãi:~i'+ L. [Zi~i~ i~=`:'#h}..i=
:~#%c~.tt>#'#.i3.Fa 1 bC. \wC:t#i't. ` lo the base .#`3anb1:. 22 .? 2.(.4I,~:,; r..".
~:.Z3.. a~~... . ..>.: `~:~~ #t=.,a \,\.3:, .~a~ ,Y~.t~#> ~~..>i,i.t i}.:.~~.

.
i \ = c ~ , .i. \r i is r in #-. . ` Z ~.. . . - i in the ~~ ~ = _ 2 a: C\ '-tL"
l.,.:3:; f#.: a t~~ \.\ . .:'f~\,> =i`T',. ~~~~~f. i ~.1 ~.tcs .1.., - i':4 \?.~.~C. x.~ ~#.:
bLl.?\. of a Pa ,:.a.ui..i. .\:""O.. t~:,C~ ;.}2~4:i'.`:' ~.~.rx i.~'c.#~ti..-:-f,x L?. ~.~'~:= cap ~~. ~ ),~~C:n~,f 3~_.':`!~ : 30 t } ~` . . ~ `i.ia,^s t '~~ft ,~,.~a\~.aJ. ~ \~.\,=.# }. . ... .

tw. , 1.t:.i.. ~~..- ::Y . -,.l :~~.I.,:i;:' ~ of .i?:Ã`= ~ tml orFt.l 4it Ãh~. ..., .\t' ~ '? ~ a:F._. ...t.~~~. ~~ ? }~ ~, ,.:<'#.l 3i =; ~ <3.. .. .~l~~, 7.::~
..~.0 i\. = 1 ; - d , . a~.i. , ~~'\.t~~.t,., ...'~\- i:.L..~ ,_.. ~ ~T= . 't\ ~1 1\.~# C:: -ITl i.r~.; k~?i.
~: õ~# \~. "~t. \ai:x~ C-! i . v i' - = ~
o:~ ..~ ? iZ:`3. ::~~`#.~1..: L:~i?~].~.~.,,.~..~t ..~~} iti z~t,. ~,~: ~? t Ã.~:,-. .~te::3~i~-:. \ ? t_.#L.- ~.:r.L> ~:tf?, z.': ,...s.. ~ ~
t. r:<#ii .....t ... wj?.m..\d ^,{` S:oixi.o?u s Ei ~~"w+ . of' tj-lL` bi>iE.
and ?.?l+. . 3;ti?' a' :t-C, `._ t : ;a;~ Ii the [.ol#.,.Ei=Ã.3ct 20 is o., : ,si... ..:;71f:.1,., , ..
#,. .. by dLfi %:f # ..

:.tt a'#'e:3. t h.: is f-ip within .t3? ke ~\. or l ~ ?' t2 i..#'~.t3. ':5>.a tfiEt., i~F
3r)- ..t. (.4;,>, the .:

~~>

i Btas? W.;Y thi: si33t-miala141g s.:i?\...: i?; 0>? th. s.a .s aI;`~:
`'Sti...:: rÃe..\. ~ . W.i.a. k2 ~\ is:~a~'~?i,, TF Z'{3~..i.i. the , F':1: t, S;1Ã'~:.Lt is i'..~i= .,.t=t i ~'~4L:.i,.x\ :~ by i?. > Yc..=i>=E : ij i):z t~ , ~ii~':

, <
y=Z ,.~ ~ i ,.a .: i . ~:. ~ ~ \ ~ 3 ~ ~~ ..t SiT .` ''t ~5. t: 'i ..3.f, .
#23~..i~A~~S.;~.
~Z i_~\ = iiZ,.: .,i.:~=
i = ;Z~~~. . ~ \
.l. k kiii3?w ~43~1 #'~ , \ ~~~ t._.
.a>kZ\ d;.1; x \w.i+.iNolho .\.~...~;.3.i > ~r,.,;,, `Z ~ ~~ i \~~~~C =3~'L'4 t 2 ~ ~ tV:e t ~'i ~< i# ai 'r i \ tki +~ \2 . ,t~ r\
`' \``.
i a.~~.a ~i3. \,. ~~~,.;.,~.i,.:t~ ~= A 2~. Aif~. E -$? t~=t .k. ~Z\?n~:.:`~
a.,~ :`~.~e~~w .i>:f~ ~.~.L.~ii.;.F~`~. ,~., .it:i \,a,f?~Z` . t . .. . ,. k.~
~. _ ..

.. '>t .a 1~Y , ; } {~ p( ~t~ = = i ~ Ã., .ti~`a.
~~.ay k.,i.,..i,.r t r ~\ ~) )~' ..~t Z #:):.i oZ1.. t~ii} # };LM~Z: L 7 ~.. ~r'~A~ :.i~).. t.Er \.:(at...
t :_.:'' x.ia.\... =.:.J.\a :Z.Z2:C~.: ,xLi.~`~\. .. 5.,\.

.~. <. ~;. x.... .....
in op:i 3b+.. s E...i,e i.2,'>iom or dh:`l'.\l=n a:.i n;n313',?vZ`d by W.< `
a Wr" a t ~ ri 3ar~; >\i.}f. i t ~ \4x `v ~~ ~~~` \ p ~: )t 2se `~ ~ ~ ?t5 ',. 4 ~tr.{
r ,f }ST i :, . 2~t t! aE f. i y=\Z =¾~~ `,~=~ y) . ~ (= -.. ~ ,=
x-C xr.. d..~A o5 .
in: 2 \Z=+...2~=.\an \~..~. Z ~.?Y~.3S `.4L23.a.~unF;.l2~., ~~Wt:t~~~~34= ~ ~
~:2Aa ~L~.:.:>,~td~.5.2:='t., t~.3., h\k ~.``4: i\.t2~\~t:\r Pr.~~nf.:.k~ia az zr v ~ ~~ )t 7.iA) )y af F1:=" ~ F ]`} ~k.tv'Z3.1i:
23~.\5..:\~4`, t,.. \, k.a.ti A~~.i~Sa ~. }~ d.

~ z I\ :~~-1, T~,:~~-fi. I~~~I' 1A, O>...; .'~?~.fK V~.C:~' ~.
M. .
:i v . i '. in?..~~~ Z ..~.aotk.?.t,og\\Cat,. huJ.awl i r 0 bia,.i3: i3 Z."n.it za :..,.:a ;,'Z?'= ~.., i`,.3...sr#- a~I~.~ t~Z.#.~:ià FÃ'%:ct.plt3:t :lliu3,,t...~i?ElÃsI. lt?cz a:
~~~dh.n _hW Zf-yi ~~:Z.~g ~~'~:~a 't~~~ #.L~~-d iR?vti~i:l ,~...L, i\NA fami'FpaÃ=d\.ke6J or platc}t:,~~~":aicb i`.. .n,:#., AlpC #,gn}L.a 20 i Ã...t..

:`;fi acee.1 a,.l ?z?.,< :;3Ã .. t ~} .~i ;.ff ~ ~i-} ,,.#Z.~:,..E

If ri3e Z;\?n.......i ':\ Ahl?iZ.c.n63i w`{~;3., ?:' bLE.m-,.. s4at ~'~:bl\.3) :i,\- .a #.:\ .f A . " i~2.,. L.~~ =~ ~...;
\
. . .. .. . a~ ~~-~ ~2.~. #~\.#~vz;LaiG= \
= f :L~~'f ~.3 :a`.C ~~..i,~-s: .::\\ >"?~';:~~.z3L,~i:~ =.~i ~.\.~L:, i~~~i?i?~A<~:~3.e b~#'~'i'3.,. .,~.ti3.t,ke~3~2.. Z?~~:;,3.i~{~ ~, :~:~:i~.i~~'i.f3.F \.a~.a :}~; ?\~;.:>t~:~.
i~~} ~, i~~~Ls??Y~*:i>.~ ~ t~'=a ~ w:L ~\~A Z;:..~ts,~3~ .. TI:~~" E,l64#' ~ ~, f_.~..+~. i (.,i~:.~` , ~. \;.
~E~
. YA.~a=.. \,aa= `#~i,? -~.. i~.'<i3 x ~. ,`t?.i=.~~ Ã~,.i.~:i,t C }..¾ ~ `2 ~i >õ Dow ': ). . s. .\ . ~ ~ :"l \:~~~t2 i= _ ~`.:~,v ~,~:=i~~r.t~~:L:v.?~~ i.,.aa?..~~.~.=`a~i?#ZE., i:l.:
A..~3., t.~'if~ii:?.S::t~. 1..cl:,~f~ ,3. .:~~~~. I~~...'.Ã~'. ~c\.i= 'f \.3.
=. .,~. .~~~~.~:,.
\ = ) 1 ::t\., ~\.a?~:~.\. :?~~
E. ~'2 ~3i.?4~: .3 ~ s f 3. ~:a.?.+r?~' :~~.A i-~L< . 3 L'{n.~i aM. . ..3<..[, .\n..}owd 3 a.#=n?= , t:.uA} \ x] ..,: \.= ~./,_-r~Ã;[\i ,Lir.M of Ã.iS.dnci.`\j- LF[ d2#ffied, F-J\ A .adft v:':2>.?i >.t2s .we:4?

w.3.2L:rZ, o..?u:fE E .4;?'s no;nÃl ItsUfS.OU=iT.iaÃ'... 4,.. ....fn... .
:.L: . -,~\.i ,..ii~=
\:.= # i.. :.?. \3.1Ã~ Ã . ,i, }?:< #~t. `,iS3l i-.i '~ l3l ~~~ E ( ~~) ?S
= , ;4 Ln.~~. S. 3.eF.=:3.2 \
~`ii :~ .''' si#\,Al ta3 ~A..,~#. S ' ?~`F3i?ni'.> acid ~..= ~. .Ya.:v~ ~
a<.a .tix..
~~'= k ~)' ~.iAt#a..
:a~t \,y. ;, , m i = =.
' a. t7.
hZ T? i. LO `. 4 . The #:s.1~.'".#Ikli:Yn to a up =.

i^

..a t ~ ` Y ' L,i~i2~'ts~ gC~ },~.:~.Gi been '3 a'Z'iõ3 Z a:c'.~r so ~i" \ x~t `' y , r,~.rl:'G;t~ i~ .(~~. ~~,.~.~ ".t :.\. . ..1~; i.i.~.,1r o . tt.~r..,4:\
~k" t tt t~ 4?, t7. : if,s .r}\\ ,~ }Z~y t.K..\ tt~.}=.a. .~p ;~:i t\ ie`` \r,\~. 2t ~, C t k.
~ t.ir. a, ,~.\r.~ ~t~..~.> ~~~ ~a~;.Fr>{~.~:~t#:.w a.. ~\` "S~ ~j?~:.
.~. ~~.,i.:,.zrl,. F~ I#\ r.:, r.: a,..
wai. \ Z` of aA 1 `2 5:t Wut1.3;?e v:CI.?i`=F#. It$.FflC.d i~ 1us.. \hwn O.k i qua, tt? : nF2#
dry. z.tL
Z F \:

.~ `.;. 3.ir t }~.
?:.t3 i t t"M`?i.Y tAcc\ \ ",ur r prL?ce..4 :~ , ;.,L~ to , ~'~a''~i Fi:.3~ k2r rFoJk sizes anci ih,. - the I;k.:'X \~r i;C:3.:.a.z t.:.~~tt t r,.
ii.:-v1::
a ~F.s:~i. r1.ati,:f'\S 1t 1; '~ l t1:;1,+ ~5, ~
~~ dz? .Ã t;'' {L.; , z.F. .FatAÃ:a.
t` t? ~.~. - ~f rzj~;il..a.. ,... .lE:~
a r,~.t3.F.i:: of E.:.1~~> c'~4`F'Il`r:Ie~'~1~:~,it.z:;i~ t:~i1 `:~a. ' t~ '~
? .a,.$. 3 ~õ~`=:tt t t 1..i.`.
:.:..t, ~: < ~ ~ . .:z#. a,,.,...~,,....
:~:
A nLrv;>.2"a2. ,=M2.0>'\ b\: \ aeF~~t thZ` p`.i'~:~. and host i..F`w:?uZ:.

F t .`~` -r< y :r3 . bone 3.~~i.~.~1rF.~. ~,~2.~~\.!:`~: !~ ~vt -~: g. . :t\.#r \ `}
i.>:~ .. .-.. ... .a i1~.:r .~.i.. .,\#..:33a=:Ft~a`..t;~.~! ~}Z. r.~~+L~.fr t ,i~i:=~f2 q .,> ,. :.st,.i,. ;~ Z.

Fffl ~ Ft`.. ;. aX?~:F k}f_9N4'~ ~ 12 ? ~. i~:~?' '~~4. 1;~Ai.`r ~ ~' `$~ F~
3j'," V~\> ~~`~' i t ~'\=';F,u.. r `?. . .~,, ~.~~ ~.. 7 ~ ~F~.: S

:#wtxx St:yif' .Ã? '#?i ...?t ~;: b-.d.;<at ~i~ tx=?i t.a.: .
~='`~~F?õ`x:;\ a44 .\\ p4=i t .~aa~' ~?.~~":~l. ..L.. l! t_>~`}r >1~ '~L`:3 3.:3 S';i e i~ ~ ~. ..\1~ : Z~= ~ "l i'{~ \.. 3.\ ... .aa ~~~ '~::
Z ~ a-, Y1..~~~
Y.'~~
\`. E.Z??r , . \. t,FS::ie<khFifi o.Clhi' ica~a.~:iF~?a F~ ignnC at:w.
i .
?~`3:t. F i.#:4 ;`..F~ .`?~:3. 1`v : t"aC},..i3 to ~~~.?~: ,. \ t\~isJk:.

.14>_1;.ti, a~ic?l <:ii: r iv.^.dL=;{ k3::av~ N.`L`.~n .dc ti~~,., F~?Y., t..?.':~?..
f i r i.Fi.C: the \<.p.2r1.kb>x b'C.h#it d#.#:FL3g or .:F3:tt.i d.:ifoJk~ 20 a t.\
o &';
:i..'fi\ z: <$....>:.i< t.`ii,ch cells :#,~A2 ii.".fu a.fAf,}3:;e.F#i t1t a.F
fõ . ..
;~~z t3m ~ ?;a 1.a. F~.a ~.
\ ~ #' ~, ::=Z, a.3.. ;`
F ` F `\ L ~' ~~~\ L~ r,. t `: ~:t~~.~t~... ~ F.a. ,~:<~,1 2\\ .4i, k>, . .a,:=\~2. ~. ~1!?b. ~ . .~ ~~F ~
k~ - r._~ a \, i:ti ,.3. ~i\ r~i:# ~ .. :,F._;:2:t.:.i..=\i ~. 1 t? . \ ~, ~ _ . . .. ~ .:r ~'~'~
\ r .~5 .\ i~j a:! 't,~..ti3, . ~;

t`:'\F.. .rM w. k d ioit t,<oI 3 ? ~P/oc,.fiG= ,tFif:Ff, 1-lf3wi vZ=#, F=he a.i#ZeFF`,??i~. :h. =. L. u ,...a ,, ~ t .
. . . . . . t , ta4n . 1, F \ .t.
t\
.Z_t'#\ .i''.d3.?t .h\'bi 2. 't>i..a.:. .. " ,a,hodinS:;rat:R ydich Fi3c Y, bee.t3 dG.:wFibC-d.`~~ ? i 3 s .,~~:a f .. ...,..,...,.e sa'..;,:,d ' ,.3'tr.i(a'4`'e tat~L'`#~thaI1rL~,.kd`e, Z?dhC.. .s wili._.i?, \v:'.a.: aAi,, E5 i. the Jf:i4pe of{ifiLa gFU2i., Fi.
zF",`AaF.;t?Lt. .J {,.taz~.;.=ti by "ho "

Claims (24)

1. A cartilage repair assembly for repair of a defect in articular cartilage comprising an allograft bone base member and a cancellous allograft bone cap member mounted to said base member, said cap member possessing at least one substantially demineralized region.
2. A cartilage repair assembly for repair of a defect in articular cartilage comprising a sterile mineralized allograft bone base member defining an axial bore and a through going bore intersecting said axial bore, a demineralized cancellous allograft bone cap member mounted to said base member in said axial bore, said cap member being treated to be non-osteoinductive, said cap member defining a through going bore which is adapted to be aligned with said base member through going bore, said allograft bone base member being sized to have an interference fit in a cut away opening in a cartilage defect area and fastening means inserted through said base member and cap member hold the same in a fixed relationship.
3. A cartilage repair assembly as claimed in claim 2 wherein said mineralized allograft bone base member is cylindrically shaped.
4. A cartilage repair assembly as claimed in claim 2 wherein said allograft bone base member axial bore is a blind bore with at least one through going bore running from the base of said blind bore to the distal end of the base member.
5. A cartilage repair assembly as claimed in claim 2 wherein said allograft bone base member has a plurality of through going bores running the length of the base member.
6. A cartilage repair assembly as claimed in claim 2 wherein said cap member comprises a top disc shaped section and a stem extending from said top disc shaped section.
7. A cartilage repair assembly as claimed in claim 6 wherein said stem defines a through going bore running transverse the axis of the stem.
8. A cartilage repair assembly as claimed in claim 6 wherein said cap member top section is cylindrical and is about 3mm in thickness.
9. A cartilage repair assembly as claimed in claim 5 wherein said plurality of through going bores run parallel to the center axis of the base member.
10. A cartilage repair assembly as claimed in claim 2 wherein said cap member is demineralized to a calcium content of less than 0.2 percent and treated to remove osteoinductivity.
11. A cartilage repair assembly as claimed in claim 9 wherein said bores have a diameter ranging from about 0.5mm to about 2.0mm.
12. A cartilage repair assembly as claimed in claim 2 wherein said fastening means is a cylindrical pin member mounted in said base member bore and said cap member through going bore.
13. A cartilage repair assembly as claimed in claim 2 wherein said fastening means is constructed of allograft cortical bone.
14. A cartilage repair assembly as claimed in claim 6 wherein said cap member top section has a top surface is milled to a degree of curvature that matches the physiological curvature of the cartilage area being repaired.
15. A cartilage repair assembly as claimed in claim 2 wherein said cap member contains milled cartilage pieces and a carrier.
16. A cartilage repair assembly as claimed in claim 2 wherein said cap member contains one or more additives taken from a group consisting of growth factors(FGF-2, FGF-5, FGF-7, IGF-1, TGF-.beta., BMP-2, BMP-4, BMP-7, PDGF, VEGF), human allogenic or autologous chondrocytes, human allogenic or autologous bone marrow cells, stem cells, demineralized bone matrix, insulin, insulin-like growth factor-1, transforming growth factor-B, interleukin-1 receptor antagonist, hepatocyte growth factor, platelet-derived growth factor, Indian hedgehog and parathyroid hormone-related peptide or bioactive glue.
17. A cartilage repair assembly as claimed in claim 2 wherein on the top section of said cap member is demineralized to a residual calcium content less than 0.2%.
18. A cartilage repair assembly as claimed in claim 2 wherein said cap member is constructed with a disc shaped section having at least a top portion non-osteoinductive and a cylindrical shaped stem section extending from said disc shaped section.
19. A cartilage repair assembly for repair of a defect in articular cartilage comprising a cylindrical sterile mineralized allograft bone base member defining a blind bore and a through going bore communicating with said blind bore and positioned transverse to a central axis of said cylindrical base member, an allograft cancellous bone cap member demineralized to have a calcium content of less than 0.2 percent and treated to remove osteoinductivity mounted in said base member blind bore, said cap member including an extended stem which defines a through going bore which can be aligned with said base member through going bore, said allograft bone base member being sized to have an interference fit in a drilled bore in a cartilage defect area and cylindrical pin member mounted in said base member through going bore and said cap member stem through going bore.
20. A cartilage repair assembly for repair of a defect in articular cartilage comprising a sterile mineralized allograft bone base member defining a blind bore, a transverse through going bore intersecting said blind bore, a plurality of through going bores running through said base member parallel to a central axis of the base member and a demineralized cancellous allograft bone cap member mounted to said base member, said cap member being treated to remove osteoinductivity, said cap member defining a through going bore which can be aligned with said bore member bone cartilage cap, said allograft bone base member being sized to have an interference fit in a drilled bore in a cartilage defect area.
21. A cartilage repair assembly as claimed in claim 20 wherein said cap member is demineralized so that it has a calcium content less than 0.2 percent.
22. A cartilage repair assembly as claimed in claim 20 wherein said cartilage repair assembly is cylindrically shaped.
23. A cartilage repair assembly as claimed in claim 20 wherein said cap member contains one or more additives taken from a group consisting of growth factors(FGF-2, FGF-5, FGF-7, IGF-1, TGF-.beta., BMP-2, BMP-4, BMP-7, PDGF, VEGF), human allogenic or autologous chondrocytes, human allogenic or autologous bone marrow cells, stem cells, demineralized bone matrix, insulin, insulin-like growth factor-1, transforming growth factor-B, interleukin-1 receptor antagonist, hepatocyte growth factor, platelet-derived growth factor, Indian hedgehog and parathyroid hormone-related peptide or bioactive glue.
24. A cartilage repair assembly as claimed in claim 20 wherein said cap member has a top surface that is curved to match the physiological curvature of the cartilage area being replaced.
CA2675170A 2007-01-24 2008-01-23 Two piece cancellous construct for cartilage repair Expired - Fee Related CA2675170C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/657,042 2007-01-24
US11/657,042 US7837740B2 (en) 2007-01-24 2007-01-24 Two piece cancellous construct for cartilage repair
PCT/US2008/051796 WO2008106254A2 (en) 2007-01-24 2008-01-23 Two piece cancellous construct for cartilage repair

Publications (2)

Publication Number Publication Date
CA2675170A1 true CA2675170A1 (en) 2008-09-04
CA2675170C CA2675170C (en) 2014-09-30

Family

ID=39721812

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2675170A Expired - Fee Related CA2675170C (en) 2007-01-24 2008-01-23 Two piece cancellous construct for cartilage repair

Country Status (4)

Country Link
US (2) US7837740B2 (en)
EP (1) EP2162094A2 (en)
CA (1) CA2675170C (en)
WO (1) WO2008106254A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112704588A (en) * 2020-12-21 2021-04-27 济宁医学院附属医院 Personalized customized articular cartilage injury repair device based on 3D printing

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8563232B2 (en) 2000-09-12 2013-10-22 Lifenet Health Process for devitalizing soft-tissue engineered medical implants, and devitalized soft-tissue medical implants produced
US7067123B2 (en) 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
WO2005058207A1 (en) 2003-12-11 2005-06-30 Isto Technologies, Inc. Particulate cartilage system
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US7815926B2 (en) 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
EP1916964A4 (en) 2005-08-26 2015-11-04 Zimmer Inc Implants and methods for repair, replacement and treatment of joint disease
AU2006292224B2 (en) 2005-09-19 2013-08-01 Histogenics Corporation Cell-support matrix and a method for preparation thereof
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
US20090012629A1 (en) 2007-04-12 2009-01-08 Isto Technologies, Inc. Compositions and methods for tissue repair
US20090024224A1 (en) * 2007-07-16 2009-01-22 Chen Silvia S Implantation of cartilage
EP2194926A4 (en) 2007-09-14 2013-10-16 Purdue Research Foundation Demineralized cancellous bone scaffolds
CA2717725A1 (en) 2008-03-05 2009-09-11 Musculoskeletal Transplant Foundation Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
US8685432B2 (en) * 2008-03-25 2014-04-01 University Of Utah Research Foundation Controlled release tissue graft combination biomaterials
CA2728312A1 (en) * 2008-06-19 2009-12-23 Synthes Usa, Llc Bone screw purchase augmentation implants, systems and techniques
US9192695B2 (en) 2008-11-20 2015-11-24 Allosource Allografts combined with tissue derived stem cells for bone healing
US10610364B2 (en) * 2008-12-04 2020-04-07 Subchondral Solutions, Inc. Method for ameliorating joint conditions and diseases and preventing bone hypertrophy
WO2010083051A2 (en) 2009-01-15 2010-07-22 ProChon Biotech, Ltd. Cartilage particle tissue mixtures optionally combined with a cancellous construct
NL2002742C2 (en) * 2009-04-09 2010-10-12 Univ Delft Tech Mechanical device for tissue regeneration.
WO2011031642A2 (en) * 2009-09-08 2011-03-17 Musculoskeletal Transplant Foundation Inc. Tissue engineered meniscus repair composition
WO2011031637A2 (en) * 2009-09-08 2011-03-17 Musculoskeletal Transplant Foundation Inc. Tissue engineered meniscus repair composition
JP2013511356A (en) 2009-11-20 2013-04-04 ニー・クリエイションズ・リミテッド・ライアビリティ・カンパニー Device for variable angle approach to joints
CN102740789A (en) 2009-11-20 2012-10-17 膝部创造物有限责任公司 Instruments for targeting a joint defect
AU2010321743A1 (en) 2009-11-20 2012-07-12 Knee Creations, Llc Coordinate mapping system for joint treatment
WO2011063240A1 (en) 2009-11-20 2011-05-26 Knee Creations, Llc Implantable devices for subchondral treatment of joint pain
US8801800B2 (en) 2009-11-20 2014-08-12 Zimmer Knee Creations, Inc. Bone-derived implantable devices and tool for subchondral treatment of joint pain
US8951261B2 (en) 2009-11-20 2015-02-10 Zimmer Knee Creations, Inc. Subchondral treatment of joint pain
US8821504B2 (en) 2009-11-20 2014-09-02 Zimmer Knee Creations, Inc. Method for treating joint pain and associated instruments
KR20120104580A (en) 2009-11-20 2012-09-21 니 크리에이션스, 엘엘씨 Navigation and positioning instruments for joint repair
US8551525B2 (en) 2010-12-23 2013-10-08 Biostructures, Llc Bone graft materials and methods
WO2012097506A1 (en) * 2011-01-19 2012-07-26 北京大学第三医院 Matrix for repairing and regenerating articular cartilage and method for preparing the matrix
US20140236312A1 (en) * 2011-05-10 2014-08-21 Mark R. Appleford Cortical bone scaffold for guided osteon regeneration in load-bearing orthopaedic applications
US8920511B2 (en) 2011-11-17 2014-12-30 Allosource Multi-piece machine graft systems and methods
US10172651B2 (en) 2012-10-25 2019-01-08 Warsaw Orthopedic, Inc. Cortical bone implant
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
US9265609B2 (en) 2013-01-08 2016-02-23 Warsaw Orthopedic, Inc. Osteograft implant
EP2953581B1 (en) 2013-02-05 2020-09-16 University of Utah Research Foundation Implantable devices for bone or joint defects
AU2014218734B2 (en) 2013-02-22 2018-03-15 Allosource Cartilage mosaic compositions and methods
AU2014225458A1 (en) 2013-03-07 2015-07-09 Allosource Consistent calcium content bone allograft systems and methods
WO2014151939A1 (en) 2013-03-15 2014-09-25 Allosource Perforated osteochondral allograft compositions
EP2970882B1 (en) 2013-03-15 2018-11-28 AlloSource Cell repopulated collagen matrix for soft tissue repair and regeneration
US9730796B2 (en) 2014-05-16 2017-08-15 Allosource Composite bone constructs and methods
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
US11666447B1 (en) * 2015-03-05 2023-06-06 Taq Ortho, LLC Bone implant augment and offset device
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
US20170056190A1 (en) * 2015-08-27 2017-03-02 Wright Medical Technology, Inc. Subtalar biofoam wedge
EP3359088A4 (en) * 2015-10-05 2020-03-04 Formae Inc. Medical implant and anchoring system for a medical implant
EP3380025B1 (en) 2015-11-25 2021-01-27 Subchondral Solutions, Inc. Devices for repairing anatomical joint conditions
KR20240018687A (en) 2017-06-30 2024-02-13 알로소스 Cellular bone grafts, and methods of manufacture and use
US10786370B2 (en) 2017-12-28 2020-09-29 Industrial Technology Research Institute Cartilage repair implant, auxiliary surgical tool kit and cartilage repair system
US11883302B2 (en) 2021-11-22 2024-01-30 Warsaw Orthopedic, Inc. Spinal implant having a compressible insert
CN117398220B (en) * 2023-12-13 2024-04-02 北京爱康宜诚医疗器材有限公司 Cartilage repair prosthesis

Family Cites Families (539)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3400199A (en) 1965-02-26 1968-09-03 Leslie L. Balassa Wound-healing cartilage powder
US3478145A (en) * 1964-09-15 1969-11-11 American Home Prod Chromatographic purification of virus with brushite modified by autoclaving
US3476855A (en) * 1965-02-26 1969-11-04 Leslie L Balassa Sterilizing and enhancing activity of a finely divided cartilage powder
US3551560A (en) 1967-10-02 1970-12-29 Heinrich F Thiele Process of reconstructing tendons,cartilage,nerve sheaths,and products
US3772432A (en) 1971-01-11 1973-11-13 Lescarden Ltd Cartilage compositions for dental use
CA992255A (en) 1971-01-25 1976-07-06 Cutter Laboratories Prosthesis for spinal repair
US3966908A (en) * 1973-11-29 1976-06-29 Lescarden Ltd. Method of treating degenerative joint afflictions
US4172128A (en) 1975-03-26 1979-10-23 Erhard Thiele Process of degrading and regenerating bone and tooth material and products
US4060081A (en) 1975-07-15 1977-11-29 Massachusetts Institute Of Technology Multilayer membrane useful as synthetic skin
US4201845A (en) 1976-04-12 1980-05-06 Monsanto Company Cell culture reactor
US4296100A (en) 1980-06-30 1981-10-20 Franco Wayne P Method of treating the heart for myocardial infarction
US4378347A (en) 1980-06-30 1983-03-29 Franco Wayne P Composition for treating the heart for myocardial infarction
US4400833A (en) 1981-06-10 1983-08-30 Kurland Kenneth Z Means and method of implanting bioprosthetics
US4442655A (en) 1981-06-25 1984-04-17 Serapharm Michael Stroetmann Fibrinogen-containing dry preparation, manufacture and use thereof
AT369990B (en) 1981-07-28 1983-02-25 Immuno Ag METHOD FOR PRODUCING A TISSUE ADHESIVE
US4394370A (en) 1981-09-21 1983-07-19 Jefferies Steven R Bone graft material for osseous defects and method of making same
US4458678A (en) 1981-10-26 1984-07-10 Massachusetts Institute Of Technology Cell-seeding procedures involving fibrous lattices
US4479271A (en) 1981-10-26 1984-10-30 Zimmer, Inc. Prosthetic device adapted to promote bone/tissue ingrowth
US4505266A (en) 1981-10-26 1985-03-19 Massachusetts Institute Of Technology Method of using a fibrous lattice
JPS5891755A (en) * 1981-11-26 1983-05-31 Sunstar Giken Kk Epoxy resin composition and its preparation
US4501269A (en) * 1981-12-11 1985-02-26 Washington State University Research Foundation, Inc. Process for fusing bone joints
IL68218A (en) * 1983-03-23 1985-12-31 Univ Ramot Compositions for cartilage repair comprising embryonal chondrocytes
US4801299A (en) 1983-06-10 1989-01-31 University Patents, Inc. Body implants of extracellular matrix and means and methods of making and using such implants
US4932973A (en) * 1983-09-30 1990-06-12 El Gendler Cartilage and bone induction by artificially perforated organic bone matrix
US5155214A (en) 1984-03-05 1992-10-13 The Salk Institute For Biological Studies Basic fibroblast growth factor
US4609551A (en) * 1984-03-20 1986-09-02 Arnold Caplan Process of and material for stimulating growth of cartilage and bony tissue at anatomical sites
US4600574A (en) 1984-03-21 1986-07-15 Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte Method of producing a tissue adhesive
US4757017A (en) * 1984-09-14 1988-07-12 Mcw Research Foundation, Inc. In vitro cell culture system
CH665348A5 (en) 1985-01-09 1988-05-13 Sulzer Ag IMPLANTS.
CH665770A5 (en) 1985-01-25 1988-06-15 Sulzer Ag PLASTIC BONE IMPLANT.
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
CA1260391A (en) 1985-03-28 1989-09-26 Karl A. Piez Xenogeneic collagen/mineral preparations in bone repair
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4627853A (en) * 1985-05-29 1986-12-09 American Hospital Supply Corporation Method of producing prostheses for replacement of articular cartilage and prostheses so produced
US5053049A (en) 1985-05-29 1991-10-01 Baxter International Flexible prostheses of predetermined shapes and process for making same
US4681763A (en) * 1985-06-11 1987-07-21 University Of Medicine And Dentistry Of New Jersey Composition for stimulating bone growth
US5266476A (en) 1985-06-18 1993-11-30 Yeda Research & Development Co., Ltd. Fibrous matrix for in vitro cell cultivation
IL76079A (en) 1985-08-13 1991-03-10 Univ Ramot Collagen implants
US5604293A (en) 1985-09-12 1997-02-18 Scios Inc. Recombinant human basic fibroblast growth factor
US4656137A (en) * 1985-09-12 1987-04-07 Lescarden Inc Method of processing animal cartilage
US5439818A (en) 1985-09-12 1995-08-08 Scios Nova Inc. DNA encoding human recombinant basic fibroblast growth factor
US5859208A (en) 1988-07-06 1999-01-12 Fiddes; John C. Human basic fibroblast growth factor analog
US4994559A (en) 1985-12-17 1991-02-19 Synergen, Inc. Human basic fibroblast growth factor
US4776173A (en) 1985-12-20 1988-10-11 Angio-Medical Corporation Method for extracting a substance from animal derived material
US6005161A (en) 1986-01-28 1999-12-21 Thm Biomedical, Inc. Method and device for reconstruction of articular cartilage
US4963489A (en) * 1987-04-14 1990-10-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US5266480A (en) 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
US5032508A (en) * 1988-09-08 1991-07-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
SU1454423A1 (en) 1986-06-27 1989-01-30 Киевский Медицинский Институт Им.Акад.А.А.Богомольца Method of recovery of articular surface of cystic condyles of the femur in case of rheumatoid arthritis
GB8618374D0 (en) 1986-07-28 1986-09-03 Hsc Res Dev Corp Biological vascular prostheses
FI80605C (en) 1986-11-03 1990-07-10 Biocon Oy Bone surgical biocomposite material
US5736372A (en) 1986-11-20 1998-04-07 Massachusetts Institute Of Technology Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure
US5041138A (en) 1986-11-20 1991-08-20 Massachusetts Institute Of Technology Neomorphogenesis of cartilage in vivo from cell culture
CA1340581C (en) 1986-11-20 1999-06-08 Joseph P. Vacanti Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices
GB8708009D0 (en) * 1987-04-03 1987-05-07 Clayton Found Res Injectable soft tissue augmentation materials
US4846835A (en) 1987-06-15 1989-07-11 Grande Daniel A Technique for healing lesions in cartilage
US4880429A (en) 1987-07-20 1989-11-14 Stone Kevin R Prosthetic meniscus
US5681353A (en) * 1987-07-20 1997-10-28 Regen Biologics, Inc. Meniscal augmentation device
US5007934A (en) 1987-07-20 1991-04-16 Regen Corporation Prosthetic meniscus
US5306311A (en) * 1987-07-20 1994-04-26 Regen Corporation Prosthetic articular cartilage
US5260420A (en) 1987-07-30 1993-11-09 Centre Regional De Transfusion Sanguine De Lille Concentrate of thrombin coagulable proteins, the method of obtaining same and therapeutical use thereof
US4950296A (en) 1988-04-07 1990-08-21 Mcintyre Jonathan L Bone grafting units
US5354557A (en) 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
CH674139A5 (en) 1988-04-21 1990-05-15 Sulzer Ag
US5053050A (en) 1988-04-29 1991-10-01 Samuel Itay Compositions for repair of cartilage and bone
US4904259A (en) * 1988-04-29 1990-02-27 Samuel Itay Compositions and methods for repair of cartilage and bone
US4837379A (en) 1988-06-02 1989-06-06 Organogenesis Inc. Fibrin-collagen tissue equivalents and methods for preparation thereof
US5496722A (en) 1988-06-30 1996-03-05 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Method for producing non-neoplastic, three dimensional, mammalian tissue and cell aggregates under microgravity culture conditions and the products produced therefrom
US4950483A (en) 1988-06-30 1990-08-21 Collagen Corporation Collagen wound healing matrices and process for their production
US4902508A (en) 1988-07-11 1990-02-20 Purdue Research Foundation Tissue graft composition
DE3826915A1 (en) 1988-08-09 1990-02-15 Henkel Kgaa NEW MATERIALS FOR BONE REPLACEMENT AND BONE OR PROSTHESIS COMPOSITION
US5649904A (en) * 1988-10-07 1997-07-22 Sandoz Ltd. Method of treating cancer with a fully myeloablative regimen of chemotherapy, radiation or both
US4971954A (en) 1988-11-23 1990-11-20 University Of Medicine And Dentistry Of New Jersey Collagen-based matrices ribose cross-linked
US4963146A (en) 1989-04-20 1990-10-16 Colla-Tec Incorporated Multi-layered, semi-permeable conduit for nerve regeneration
US5191067A (en) 1989-04-27 1993-03-02 The Salk Institute For Biological Studies Fibroblast growth factor conjugates
US5576288A (en) 1989-04-27 1996-11-19 The Salk Institute For Biological Studies Fibroblast growth factor conjugates
US4994084A (en) 1989-06-23 1991-02-19 Brennan H George Reconstructive surgery method and implant
US5073373A (en) 1989-09-21 1991-12-17 Osteotech, Inc. Flowable demineralized bone powder composition and its use in bone repair
US5290558A (en) * 1989-09-21 1994-03-01 Osteotech, Inc. Flowable demineralized bone powder composition and its use in bone repair
US5236456A (en) 1989-11-09 1993-08-17 Osteotech, Inc. Osteogenic composition and implant containing same
US5152791A (en) 1989-12-07 1992-10-06 Olympus Optical Co., Ltd. Prosthetic artificial bone having ceramic layers of different porosity
US5067964A (en) 1989-12-13 1991-11-26 Stryker Corporation Articular surface repair
US5118512A (en) * 1990-01-23 1992-06-02 Osteotech, Inc. (A Delaware Corp.) Process for cryopreserving biological materials and materials prepared thereby
US5425769A (en) 1990-04-23 1995-06-20 Snyders, Jr.; Robert V. Composition of material for osseous repair
FR2664808A1 (en) 1990-07-23 1992-01-24 Gersberg Eduardo System of dental implants
US5067963A (en) * 1990-08-21 1991-11-26 Washington University Method of making live autogenous skeletal replacement parts
US5336616A (en) 1990-09-12 1994-08-09 Lifecell Corporation Method for processing and preserving collagen-based tissues for transplantation
DE69111021T2 (en) 1990-10-31 1996-01-04 Gendler El Flexible membrane made from organic bone matrix for repairing and restoring bones.
US5226914A (en) * 1990-11-16 1993-07-13 Caplan Arnold I Method for treating connective tissue disorders
DE69119869T2 (en) 1990-11-23 1996-12-12 American Cyanamid Co Chimeric fibroblast growth factor
US6054122A (en) 1990-11-27 2000-04-25 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US5312456A (en) 1991-01-31 1994-05-17 Carnegie Mellon University Micromechanical barb and method for making the same
US5206023A (en) * 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
US5853746A (en) 1991-01-31 1998-12-29 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone using functional barrier
JP3385040B2 (en) 1991-02-14 2003-03-10 武田薬品工業株式会社 Glial activator and method for producing the same
US5192312A (en) * 1991-03-05 1993-03-09 Colorado State University Research Foundation Treated tissue for implantation and methods of treatment and use
DE4215137A1 (en) 1991-06-04 1992-12-10 Man Ceramics Gmbh IMPLANT FOR SPINE PILLARS
US6440427B1 (en) 1991-06-17 2002-08-27 Biovitrum Ab Tissue treatment composition comprising fibrin or fibrinogen and biodegradable and biocompatible polymer
SE9101853D0 (en) 1991-06-17 1991-06-17 Jonas Wadstroem IMPROVED TISSUE ASHESIVE
DE4120325A1 (en) 1991-06-20 1992-12-24 Merck Patent Gmbh IMPLANT MATERIAL
US5356629A (en) 1991-07-12 1994-10-18 United States Surgical Corporation Composition for effecting bone repair
US5092887A (en) * 1991-08-12 1992-03-03 El Gendler Artificial ligament produced from demineralized bone for the replacement and augmentation of ligaments, tendons and other fibrous connective tissue
US6503277B2 (en) 1991-08-12 2003-01-07 Peter M. Bonutti Method of transplanting human body tissue
US5329846A (en) 1991-08-12 1994-07-19 Bonutti Peter M Tissue press and system
US5270300A (en) 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
US5281422A (en) 1991-09-24 1994-01-25 Purdue Research Foundation Graft for promoting autogenous tissue growth
US5261422A (en) * 1991-10-29 1993-11-16 Kelly Michael P Acoustic administration of remedies process and device
US5284155A (en) * 1991-12-06 1994-02-08 The General Hospital Corporation Cartilage degradation assay system
US5513662A (en) * 1991-12-31 1996-05-07 Osteotech, Inc. Preparation of bone for transplantation
US5314476A (en) * 1992-02-04 1994-05-24 Osteotech, Inc. Demineralized bone particles and flowable osteogenic composition containing same
US5876452A (en) * 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
CA2117379C (en) * 1992-02-14 1999-11-16 Kypriacos A. Athanasiou Multi-phase bioerodible implant/carrier and method of manufacturing and using same
US6013853A (en) 1992-02-14 2000-01-11 The University Of Texas System Continuous release polymeric implant carrier
WO1993016739A1 (en) 1992-02-19 1993-09-02 Eberlin Jean Luc Collagen- and fibrin adhesive-based graft for osteocartilaginous reconstruction, and preparation method therefor
US5326357A (en) 1992-03-18 1994-07-05 Mount Sinai Hospital Corporation Reconstituted cartridge tissue
GB9206509D0 (en) 1992-03-25 1992-05-06 Jevco Ltd Heteromorphic sponges containing active agents
US5256140A (en) 1992-03-27 1993-10-26 Fallien Cosmeceuticals, Ltd. Composition for levelling skin
AU3930793A (en) * 1992-05-08 1993-12-13 Apple Computer, Inc. Textured sphere and spherical environment map rendering using texture map double indirection
DE69333466T2 (en) 1992-08-07 2004-08-19 TEI Biosciences, Inc., Boston PRODUCTION OF TRANSPLANT TISSUE FROM EXTRACELLULAR MATRIX
US5800537A (en) 1992-08-07 1998-09-01 Tissue Engineering, Inc. Method and construct for producing graft tissue from an extracellular matrix
US5195791A (en) * 1992-08-13 1993-03-23 Hu Chiu S Portable security buckle for doors
US5352463A (en) 1992-11-13 1994-10-04 Badylak Steven F Tissue graft for surgical reconstruction of a collagenous meniscus and method therefor
US5275826A (en) * 1992-11-13 1994-01-04 Purdue Research Foundation Fluidized intestinal submucosa and its use as an injectable tissue graft
EP0608546A3 (en) 1992-12-22 1995-09-27 Takeda Chemical Industries Ltd Glia activating factor (gaf), antibodies against it and their uses.
US5549904A (en) 1993-06-03 1996-08-27 Orthogene, Inc. Biological adhesive composition and method of promoting adhesion between tissue surfaces
US5380328A (en) 1993-08-09 1995-01-10 Timesh, Inc. Composite perforated implant structures
US5491220A (en) 1993-09-24 1996-02-13 Yeda Research And Development Co., Ltd. Surface loop structural analogues of fibroblast growth factors
US5507813A (en) 1993-12-09 1996-04-16 Osteotech, Inc. Shaped materials derived from elongate bone particles
US5411885A (en) 1993-12-17 1995-05-02 New York Blood Center, Inc. Methods for tissue embedding and tissue culturing
US5656598A (en) 1994-03-08 1997-08-12 Rhone-Poulenc Rorer Pharmaceuticals Inc. Use of fibroblast growth factors to stimulate bone growth
DE69533176T2 (en) 1994-03-08 2005-09-15 Osteosa Liquidation Trust, San Diego USE OF FIBROBLAST GROWTH FACTORS TO STIMULATE BONE GROWTH
DK0871414T3 (en) * 1994-03-14 2004-08-30 Cryolife Inc Methods for preparing tissue for implantation
WO1995025748A1 (en) 1994-03-18 1995-09-28 Baxter International Inc. Topical fibrinogen complex
US5916265A (en) 1994-03-30 1999-06-29 Hu; Jie Method of producing a biological extracellular matrix for use as a cell seeding scaffold and implant
US5618925A (en) * 1994-04-28 1997-04-08 Les Laboratories Aeterna Inc. Extracts of shark cartilage having an anti-angiogenic activity and an effect on tumor regression; process of making thereof
US6025334A (en) 1994-04-28 2000-02-15 Les Laboratoires Aeterna Inc. Extracts of shark cartilage having anti-collagenolytic, anti-inflammatory, anti-angiogenic and anti-tumoral activities; process of making, methods of using and compositions thereof
US5723331A (en) 1994-05-05 1998-03-03 Genzyme Corporation Methods and compositions for the repair of articular cartilage defects in mammals
WO1998020939A2 (en) 1996-11-15 1998-05-22 Advanced Bio Surfaces, Inc. Biomaterial system for in situ tissue repair
US7963997B2 (en) 2002-07-19 2011-06-21 Kensey Nash Corporation Device for regeneration of articular cartilage and other tissue
US5906827A (en) 1994-06-03 1999-05-25 Creative Biomolecules, Inc. Matrix for the manufacture of autogenous replacement body parts
IL110367A (en) 1994-07-19 2007-05-15 Colbar Lifescience Ltd Collagen-based matrix
US5516532A (en) 1994-08-05 1996-05-14 Children's Medical Center Corporation Injectable non-immunogenic cartilage and bone preparation
US5632745A (en) 1995-02-07 1997-05-27 R&D Biologicals, Inc. Surgical implantation of cartilage repair unit
US5769899A (en) 1994-08-12 1998-06-23 Matrix Biotechnologies, Inc. Cartilage repair unit
US5707962A (en) * 1994-09-28 1998-01-13 Gensci Regeneration Sciences Inc. Compositions with enhanced osteogenic potential, method for making the same and therapeutic uses thereof
TW369414B (en) 1994-09-30 1999-09-11 Yamanouchi Pharma Co Ltd Bone formation transplant
US5919892A (en) * 1994-10-31 1999-07-06 The Dow Chemical Company Polyamic acids and methods to convert polyamic acids into polyimidebenzoxazole films
US20010011131A1 (en) 1997-07-28 2001-08-02 Luyten Frank P. DNA molecules encoding cartilage-derived morphogenetic proteins
US5891558A (en) 1994-11-22 1999-04-06 Tissue Engineering, Inc. Biopolymer foams for use in tissue repair and reconstruction
US5709934A (en) 1994-11-22 1998-01-20 Tissue Engineering, Inc. Bipolymer foams having extracellular matrix particulates
US6599515B1 (en) 1995-01-16 2003-07-29 Baxter International Inc. Fibrin porous structure
WO1996022115A1 (en) 1995-01-16 1996-07-25 Baxter International Inc. Self-supporting sheet-like material of cross-linked fibrin for preventing post operative adhesions
US5736396A (en) * 1995-01-24 1998-04-07 Case Western Reserve University Lineage-directed induction of human mesenchymal stem cell differentiation
US5749874A (en) 1995-02-07 1998-05-12 Matrix Biotechnologies, Inc. Cartilage repair unit and method of assembling same
US5713374A (en) 1995-02-10 1998-02-03 The Hospital For Joint Diseases Orthopaedic Institute Fixation method for the attachment of wound repair materials to cartilage defects
US5695998A (en) 1995-02-10 1997-12-09 Purdue Research Foundation Submucosa as a growth substrate for islet cells
US6080194A (en) 1995-02-10 2000-06-27 The Hospital For Joint Disease Orthopaedic Institute Multi-stage collagen-based template or implant for use in the repair of cartilage lesions
GB9721585D0 (en) 1997-10-10 1997-12-10 Geistlich Soehne Ag Chemical product
US7141072B2 (en) 1998-10-05 2006-11-28 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Method for promoting regeneration of surface cartilage in a damaged joint using multi-layer covering
US20030039695A1 (en) 2001-08-10 2003-02-27 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Collagen carrier of therapeutic genetic material, and method
US5782835A (en) 1995-03-07 1998-07-21 Innovasive Devices, Inc. Apparatus and methods for articular cartilage defect repair
US5554389A (en) * 1995-04-07 1996-09-10 Purdue Research Foundation Urinary bladder submucosa derived tissue graft
US5733337A (en) * 1995-04-07 1998-03-31 Organogenesis, Inc. Tissue repair fabric
EP0821573A4 (en) * 1995-04-19 2000-08-09 St Jude Medical Matrix substrate for a viable body tissue-derived prosthesis and method for making the same
US5904716A (en) 1995-04-26 1999-05-18 Gendler; El Method for reconstituting cartilage tissue using demineralized bone and product thereof
US6060640A (en) 1995-05-19 2000-05-09 Baxter International Inc. Multiple-layer, formed-in-place immunoisolation membrane structures for implantation of cells in host tissue
US5674292A (en) * 1995-06-07 1997-10-07 Stryker Corporation Terminally sterilized osteogenic devices and preparation thereof
US6039762A (en) 1995-06-07 2000-03-21 Sdgi Holdings, Inc. Reinforced bone graft substitutes
US5782915A (en) 1995-09-15 1998-07-21 Stone; Kevin R. Articular cartilage heterografts
DE59605198D1 (en) 1995-10-06 2000-06-15 Microcloning Cccd Ab Joenkoepi COMPACT CELL CULTURE DISC
US5716413A (en) * 1995-10-11 1998-02-10 Osteobiologics, Inc. Moldable, hand-shapable biodegradable implant material
US5989289A (en) 1995-10-16 1999-11-23 Sdgi Holdings, Inc. Bone grafts
US20020111695A1 (en) 1995-11-06 2002-08-15 Mount Sinai Hospital Corporation Reconstituted mineralized cartilage tissue
US5788626A (en) * 1995-11-21 1998-08-04 Schneider (Usa) Inc Method of making a stent-graft covered with expanded polytetrafluoroethylene
IL116477A (en) 1995-12-21 2000-02-29 Hadasit Med Res Service Bone graft substitute and process for producing same
US5814084A (en) 1996-01-16 1998-09-29 University Of Florida Tissue Bank, Inc. Diaphysial cortical dowel
US5964724A (en) 1996-01-31 1999-10-12 Medtronic Electromedics, Inc. Apparatus and method for blood separation
US5842477A (en) 1996-02-21 1998-12-01 Advanced Tissue Sciences, Inc. Method for repairing cartilage
US6352558B1 (en) 1996-02-22 2002-03-05 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Method for promoting regeneration of surface cartilage in a damage joint
US6221854B1 (en) 1996-03-05 2001-04-24 Orquest, Inc. Method of promoting bone growth with hyaluronic acid and growth factors
US5700774A (en) 1996-03-26 1997-12-23 Genetics Institute, Inc. Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same
US5788625A (en) * 1996-04-05 1998-08-04 Depuy Orthopaedics, Inc. Method of making reconstructive SIS structure for cartilaginous elements in situ
US5755791A (en) * 1996-04-05 1998-05-26 Purdue Research Foundation Perforated submucosal tissue graft constructs
EP2105138A3 (en) 1996-04-19 2013-06-05 Osiris Therapeutics, Inc. Regeneration and augmentation of bone using mesenchymal stem cells
ES2210526T3 (en) * 1996-06-04 2004-07-01 Centerpulse Biologics Inc. CARTILAGO PRODUCTION PROCEDURE.
US6280473B1 (en) 1996-08-19 2001-08-28 Macropore, Inc. Resorbable, macro-porous, non-collapsing and flexible membrane barrier for skeletal repair and regeneration
US6666892B2 (en) 1996-08-23 2003-12-23 Cook Biotech Incorporated Multi-formed collagenous biomaterial medical device
US5759190A (en) 1996-08-30 1998-06-02 Vts Holdings Limited Method and kit for autologous transplantation
US6569172B2 (en) 1996-08-30 2003-05-27 Verigen Transplantation Service International (Vtsi) Method, instruments, and kit for autologous transplantation
US5989269A (en) 1996-08-30 1999-11-23 Vts Holdings L.L.C. Method, instruments and kit for autologous transplantation
US6189537B1 (en) * 1996-09-06 2001-02-20 Lifenet Process for producing osteoinductive bone, and osteoinductive bone produced thereby
US5964805A (en) 1997-02-12 1999-10-12 Stone; Kevin R. Method and paste for articular cartilage transplantation
US5881733A (en) * 1996-09-13 1999-03-16 Depuy Orthopaedic Technology, Inc. Technique for osteocartilaginous transplantation in a mammalian joint
US6165487A (en) 1996-09-30 2000-12-26 Children's Medical Center Corporation Methods and compositions for programming an organic matrix for remodeling into a target tissue
WO1998014222A1 (en) 1996-09-30 1998-04-09 Children's Medical Center Corporation Methods and compositions for programming an organic matrix for remodeling into a target tissue
US6884871B2 (en) * 1996-10-11 2005-04-26 The United States Of America As Represented By The Department Of Health And Human Services Isolation and use of tissue growth-inducing Frzb protein
EP0931148B1 (en) 1996-10-16 2006-03-01 ZymoGenetics, Inc. Fibroblast growth factor homologs
EP0955961B1 (en) 1996-10-23 2004-03-31 SDGI Holdings, Inc. Spinal spacer
US5974663A (en) 1996-10-25 1999-11-02 Honda Giken Kogya Kabushiki Kaisha Method of manufacturing connecting rod
US6096347A (en) 1996-11-05 2000-08-01 Purdue Research Foundation Myocardial graft constructs
DE19647853A1 (en) * 1996-11-19 1998-05-20 Bioph Biotech Entw Pharm Gmbh Compounds with improved cartilage and / or bone inducing activity
US5728159A (en) 1997-01-02 1998-03-17 Musculoskeletal Transplant Foundation Serrated bone graft
US7468075B2 (en) 2001-05-25 2008-12-23 Conformis, Inc. Methods and compositions for articular repair
US8545569B2 (en) 2001-05-25 2013-10-01 Conformis, Inc. Patient selectable knee arthroplasty devices
US5866165A (en) 1997-01-15 1999-02-02 Orquest, Inc. Collagen-polysaccharide matrix for bone and cartilage repair
CA2280931C (en) 1997-02-07 2009-05-05 Stryker Corporation Matrix-free osteogenic devices, implants and methods of use thereof
US6146385A (en) * 1997-02-11 2000-11-14 Smith & Nephew, Inc. Repairing cartilage
US7041641B2 (en) 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
US20010016646A1 (en) 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
US5866415A (en) 1997-03-25 1999-02-02 Villeneuve; Peter E. Materials for healing cartilage and bone defects
US6001352A (en) 1997-03-31 1999-12-14 Osteobiologics, Inc. Resurfacing cartilage defects with chondrocytes proliferated without differentiation using platelet-derived growth factor
WO1998043686A1 (en) 1997-04-03 1998-10-08 California Institute Of Technology Enzyme-mediated modification of fibrin for tissue engineering
WO1998044874A1 (en) 1997-04-04 1998-10-15 Barnes-Jewish Hospital Neocartilage and methods of use
AU738334B2 (en) 1997-05-30 2001-09-13 Osteobiologics, Inc. Fiber-reinforced, porous, biodegradable implant device
US7524335B2 (en) 1997-05-30 2009-04-28 Smith & Nephew, Inc. Fiber-reinforced, porous, biodegradable implant device
US5972368A (en) 1997-06-11 1999-10-26 Sdgi Holdings, Inc. Bone graft composites and spacers
CN1161127C (en) 1997-07-03 2004-08-11 奥奎斯特公司 Cross-linked polysaccharide drug carrier
US5910315A (en) * 1997-07-18 1999-06-08 Stevenson; Sharon Allograft tissue material for filling spinal fusion cages or related surgical spaces
WO1999009149A1 (en) 1997-08-01 1999-02-25 Massachusetts Institute Of Technology Three-dimensional polymer matrices
US6090996A (en) 1997-08-04 2000-07-18 Collagen Matrix, Inc. Implant matrix
US6110209A (en) 1997-08-07 2000-08-29 Stone; Kevin R. Method and paste for articular cartilage transplantation
US6511958B1 (en) 1997-08-14 2003-01-28 Sulzer Biologics, Inc. Compositions for regeneration and repair of cartilage lesions
DE69714035T2 (en) 1997-08-14 2003-03-06 Sulzer Innotec Ag Composition and device for repairing cartilage tissue in vivo consisting of nanocapsules with osteoinductive and / or chondroinductive factors
US20020138143A1 (en) 1997-08-27 2002-09-26 Grooms Jamie M. Cortical bone cervical Smith-Robinson fusion implant
US20010031254A1 (en) 1998-11-13 2001-10-18 Bianchi John R. Assembled implant
WO1999009914A1 (en) * 1997-08-27 1999-03-04 University Of Florida Tissue Bank, Inc. Cortical bone cervical smith-robinson fusion implant
US7048762B1 (en) * 1997-08-27 2006-05-23 Regeneration Technologies, Inc. Elongated cortical bone implant
US6309659B1 (en) 1997-09-02 2001-10-30 Gensci Orthobiologics, Inc. Reverse phase connective tissue repair composition
US6077987A (en) 1997-09-04 2000-06-20 North Shore-Long Island Jewish Research Institute Genetic engineering of cells to enhance healing and tissue regeneration
AT407117B (en) 1997-09-19 2000-12-27 Immuno Ag FIBRINE SPONGE
US5998170A (en) 1997-10-03 1999-12-07 Amgen Inc. Polynucleotides encoding hepatocyte-specific members of the FGF family
EP1027001A1 (en) 1997-10-27 2000-08-16 Sulzer Orthopädie AG Method and instruments for repairing endochondral and osteochondral defects
US6090998A (en) 1997-10-27 2000-07-18 University Of Florida Segmentally demineralized bone implant
US6652592B1 (en) 1997-10-27 2003-11-25 Regeneration Technologies, Inc. Segmentally demineralized bone implant
EP1030676B1 (en) 1997-10-30 2005-09-14 The General Hospital Corporation Bonding of cartilaginous matrices using isolated chondrocytes
EP0949298B1 (en) 1997-10-30 2005-01-12 EC-Showa Denko K.K. Composite resin composition
US20030099620A1 (en) * 1997-10-30 2003-05-29 The General Hospital Corporation Bonding of cartilaginous matrices using isolated chondrocytes
US6197586B1 (en) 1997-12-12 2001-03-06 The Regents Of The University Of California Chondrocyte-like cells useful for tissue engineering and methods
US6274712B1 (en) 1997-12-23 2001-08-14 3-Dimensional Pharmaceuticals, Inc. Analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamute 89, aspartate 101 or leucine 137
US5899939A (en) 1998-01-21 1999-05-04 Osteotech, Inc. Bone-derived implant for load-supporting applications
US6712851B1 (en) 1998-01-23 2004-03-30 Macropore Biosurgery, Inc. Resorbable, macro-porous non-collapsing and flexible membrane barrier for skeletal repair and regeneration
US7087082B2 (en) 1998-08-03 2006-08-08 Synthes (Usa) Bone implants with central chambers
DE19803673A1 (en) 1998-01-30 1999-08-05 Norbert M Dr Meenen Biohybrid joint replacement
US6123731A (en) 1998-02-06 2000-09-26 Osteotech, Inc. Osteoimplant and method for its manufacture
US7045141B2 (en) 1998-02-27 2006-05-16 Musculoskeletal Transplant Foundation Allograft bone composition having a gelatin binder
US6437018B1 (en) 1998-02-27 2002-08-20 Musculoskeletal Transplant Foundation Malleable paste with high molecular weight buffered carrier for filling bone defects
US6326018B1 (en) * 1998-02-27 2001-12-04 Musculoskeletal Transplant Foundation Flexible sheet of demineralized bone
US6458375B1 (en) 1998-02-27 2002-10-01 Musculoskeletal Transplant Foundation Malleable paste with allograft bone reinforcement for filling bone defects
USRE38522E1 (en) * 1998-02-27 2004-05-25 Musculoskeletal Transplant Foundation Malleable paste for filling bone defects
US6030635A (en) 1998-02-27 2000-02-29 Musculoskeletal Transplant Foundation Malleable paste for filling bone defects
US7019192B2 (en) 1998-02-27 2006-03-28 Musculoskeletal Transplant Foundation Composition for filling bone defects
US6056777A (en) * 1998-02-27 2000-05-02 Mcdowell; Charles L. Method and device for regenerating cartilage in articulating
US6911212B2 (en) 1998-02-27 2005-06-28 Musculoskeletal Transplant Foundation Malleable putty and flowable paste with allograft bone having residual calcium for filling bone defects
US6143293A (en) 1998-03-26 2000-11-07 Carnegie Mellon Assembled scaffolds for three dimensional cell culturing and tissue generation
US20040044408A1 (en) 1998-04-08 2004-03-04 Hungerford David S. Cell-culture and polymer constructs
JP4468577B2 (en) 1998-05-01 2010-05-26 ザイモジェネティクス，インコーポレイティド Completely recombinant tissue sealant composition
US6933326B1 (en) 1998-06-19 2005-08-23 Lifecell Coporation Particulate acellular tissue matrix
US6734018B2 (en) 1999-06-07 2004-05-11 Lifenet Process for decellularizing soft-tissue engineered medical implants, and decellularized soft-tissue medical implants produced
US20080077251A1 (en) * 1999-06-07 2008-03-27 Chen Silvia S Cleaning and devitalization of cartilage
US6293970B1 (en) 1998-06-30 2001-09-25 Lifenet Plasticized bone and soft tissue grafts and methods of making and using same
AU756785B2 (en) * 1998-07-13 2003-01-23 University Of Southern California Methods for accelerating bone and cartilage growth and repair
US6274090B1 (en) 1998-08-05 2001-08-14 Thermogenesis Corp. Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby
EP1102568A1 (en) * 1998-08-06 2001-05-30 SDGI Holdings, Inc. Composited intervertebral bone spacers
AU771701B2 (en) 1998-08-14 2004-04-01 Genzyme Corporation Methods, instruments and materials for chondrocyte cell transplantation
US6849255B2 (en) * 1998-08-18 2005-02-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem Methods and compositions for enhancing cartilage repair
US6530956B1 (en) 1998-09-10 2003-03-11 Kevin A. Mansmann Resorbable scaffolds to promote cartilage regeneration
JP2004502401A (en) 1998-09-18 2004-01-29 マサチューセッツ　インスティテュート　オブ　テクノロジー Use of growth factors and hormones for mammalian cell expansion and tissue engineering
WO2000021470A1 (en) 1998-10-12 2000-04-20 Therics, Inc. Composites for tissue regeneration and methods of manufacture thereof
US6586406B2 (en) 1998-10-14 2003-07-01 Depuy Acromed, Inc. Method of inducing or enhancing chondrogenesis with extracellular matrix containing GDF-5
US6174311B1 (en) * 1998-10-28 2001-01-16 Sdgi Holdings, Inc. Interbody fusion grafts and instrumentation
DE19851334C2 (en) 1998-11-06 2000-09-28 Aventis Behring Gmbh Flexible fibrin-based wound dressing and process for its manufacture
US6497726B1 (en) 2000-01-11 2002-12-24 Regeneration Technologies, Inc. Materials and methods for improved bone tendon bone transplantation
US6761887B1 (en) 1998-11-16 2004-07-13 Osiris Therapeutics, Inc. Alginate layer system for chondrogenic differentiation of human mesenchymal stem cells
US6165486A (en) 1998-11-19 2000-12-26 Carnegie Mellon University Biocompatible compositions and methods of using same
US6025538A (en) 1998-11-20 2000-02-15 Musculoskeletal Transplant Foundation Compound bone structure fabricated from allograft tissue
US6306174B1 (en) 1998-12-18 2001-10-23 Benoist Girard Sas Femoral component
US20020165611A1 (en) 1998-12-22 2002-11-07 Robert-Jan Enzerink Graft material convenience package
US6200347B1 (en) * 1999-01-05 2001-03-13 Lifenet Composite bone graft, method of making and using same
US6547823B2 (en) 1999-01-22 2003-04-15 Osteotech, Inc. Intervertebral implant
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
AU772682B2 (en) 1999-02-04 2004-05-06 Warsaw Orthopedic, Inc. Highly-mineralized osteogenic sponge compositions, and uses thereof
US6267786B1 (en) 1999-02-11 2001-07-31 Crosscart, Inc. Proteoglycan-reduced soft tissue xenografts
WO2000047114A1 (en) 1999-02-12 2000-08-17 Collagenesis, Inc. Injectable collagen-based delivery system for bone morphogenic proteins
US6294187B1 (en) 1999-02-23 2001-09-25 Osteotech, Inc. Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same
US6696073B2 (en) * 1999-02-23 2004-02-24 Osteotech, Inc. Shaped load-bearing osteoimplant and methods of making same
US6197061B1 (en) * 1999-03-01 2001-03-06 Koichi Masuda In vitro production of transplantable cartilage tissue cohesive cartilage produced thereby, and method for the surgical repair of cartilage damage
US6662805B2 (en) 1999-03-24 2003-12-16 The Johns Hopkins University Method for composite cell-based implants
ES2424618T3 (en) 1999-04-12 2013-10-07 Harvest Technologies Corporation Procedure and apparatus for producing platelet rich plasma and / or platelet concentrate
US7338524B2 (en) * 1999-05-10 2008-03-04 Fell Barry M Surgically implantable knee prosthesis
US7297161B2 (en) 1999-05-10 2007-11-20 Fell Barry M Surgically implantable knee prosthesis
GB9912240D0 (en) 1999-05-27 1999-07-28 Smith & Nephew Implantable medical devices
US6251143B1 (en) 1999-06-04 2001-06-26 Depuy Orthopaedics, Inc. Cartilage repair unit
US6288043B1 (en) * 1999-06-18 2001-09-11 Orquest, Inc. Injectable hyaluronate-sulfated polysaccharide conjugates
US6306424B1 (en) 1999-06-30 2001-10-23 Ethicon, Inc. Foam composite for the repair or regeneration of tissue
US6333029B1 (en) 1999-06-30 2001-12-25 Ethicon, Inc. Porous tissue scaffoldings for the repair of regeneration of tissue
US6652872B2 (en) 1999-07-06 2003-11-25 Ramat At Tel Aviv University Ltd. Scaffold formed of tissue treated to eliminate cellular and cytosolic elements
US7056885B1 (en) 1999-07-27 2006-06-06 Curagen Corporation Fibroblast growth factor and nucleic acids encoding same
US6429013B1 (en) 1999-08-19 2002-08-06 Artecel Science, Inc. Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair
US7078232B2 (en) 1999-08-19 2006-07-18 Artecel, Inc. Adipose tissue-derived adult stem or stromal cells for the repair of articular cartilage fractures and uses thereof
FR2798671A1 (en) * 1999-09-16 2001-03-23 Univ Paris Curie CHONDROCYTE COMPOSITIONS, PREPARATION AND USES
US7687462B2 (en) * 1999-10-05 2010-03-30 The Regents Of The University Of California Composition for promoting cartilage formation or repair comprising a nell gene product and method of treating cartilage-related conditions using such composition
EP1099443A1 (en) 1999-11-11 2001-05-16 Sulzer Orthopedics Ltd. Transplant/implant device and method for its production
AU1628101A (en) 1999-11-22 2001-06-04 Millennium Pharmaceuticals, Inc. Jaffa, a novel fibroblast growth factor family member and uses therefor
DE19957388A1 (en) 1999-11-24 2001-06-13 Michael Sittinger Chondroinductive and implantable substrates for cartilage healing and protection
DE19958007A1 (en) * 1999-12-02 2001-06-07 Roehm Gmbh Injection molding process for (meth) acrylate copolymers with tertiary ammonium groups
JP5209161B2 (en) 1999-12-02 2013-06-12 ザイモジェネティクス， インコーポレイテッド Method for targeting cells expressing glandular fibroblast growth receptor-3 or -2
AU779436B2 (en) 1999-12-03 2005-01-27 University Of Leeds, The Fixation technology
DE50007640D1 (en) 1999-12-15 2004-10-07 Sulzer Orthopedics Ltd PREPARATION FOR THE REPAIR OF CARTILAGE OR CARTILAGE / BONE DEFECTS IN HUMAN OR ANIMAL JOINTS
US6623963B1 (en) 1999-12-20 2003-09-23 Verigen Ag Cellular matrix
US6579538B1 (en) * 1999-12-22 2003-06-17 Acell, Inc. Tissue regenerative compositions for cardiac applications, method of making, and method of use thereof
ES2275361T3 (en) 1999-12-22 2007-06-01 Ortho-Mcneil Pharmaceutical, Inc. ANALOGS OF THE BASIC HUMAN FIBROBLASTIC GROWTH FACTOR.
US6576265B1 (en) 1999-12-22 2003-06-10 Acell, Inc. Tissue regenerative composition, method of making, and method of use thereof
US6376244B1 (en) * 1999-12-29 2002-04-23 Children's Medical Center Corporation Methods and compositions for organ decellularization
WO2001049333A2 (en) 1999-12-30 2001-07-12 Osteotech, Inc. Methods for manufacturing skeletal implants
US6379385B1 (en) 2000-01-06 2002-04-30 Tutogen Medical Gmbh Implant of bone matter
US6893462B2 (en) * 2000-01-11 2005-05-17 Regeneration Technologies, Inc. Soft and calcified tissue implants
WO2001078798A1 (en) * 2000-02-10 2001-10-25 Regeneration Technologies, Inc. Assembled implant
US7182781B1 (en) 2000-03-02 2007-02-27 Regeneration Technologies, Inc. Cervical tapered dowel
US6371958B1 (en) * 2000-03-02 2002-04-16 Ethicon, Inc. Scaffold fixation device for use in articular cartilage repair
US6591581B2 (en) 2000-03-08 2003-07-15 Arthrex, Inc. Method for preparing and inserting round, size specific osteochondral cores in the knee
US6626945B2 (en) * 2000-03-14 2003-09-30 Chondrosite, Llc Cartilage repair plug
AR027685A1 (en) 2000-03-22 2003-04-09 Synthes Ag METHOD AND METHOD FOR CARRYING OUT
ES2266187T3 (en) 2000-03-24 2007-03-01 Genentech, Inc. USE OF INSULIN FOR THE TREATMENT OF CARTILAGO DISORDERS.
EP1142596A1 (en) 2000-04-03 2001-10-10 Universiteit Gent Compositions of crosslinkable prepolymers for use in therapeutically active biodegradable implants
US6932977B2 (en) 2000-04-14 2005-08-23 Depuy Spine, Inc. Method of inducing or enhancing chondrogenesis with extracellular matrix containing BMP-4
EP2314257B9 (en) * 2000-05-01 2013-02-27 ArthroSurface, Inc. System for joint resurface repair
US6993328B1 (en) 2000-05-08 2006-01-31 Nokia Corporation Method for over the air mobile station management
US7108721B2 (en) 2000-05-11 2006-09-19 Massachusetts Institute Of Technology Tissue regrafting
ES2247113T3 (en) 2000-05-12 2006-03-01 Osteotech, Inc. DEMINERALIZED BEE IMPLANT ON THE SURFACE AND METHOD TO MANUFACTURE IT
US6488033B1 (en) 2000-05-15 2002-12-03 Cryolife, Inc. Osteochondral transplant techniques
US6686184B1 (en) 2000-05-25 2004-02-03 President And Fellows Of Harvard College Patterning of surfaces utilizing microfluidic stamps including three-dimensionally arrayed channel networks
JP5089006B2 (en) 2000-06-29 2012-12-05 ピラマル ヘルスケア （カナダ） リミテッド Compositions and methods for repair and regeneration of cartilage and other tissues
EP1296726B1 (en) * 2000-07-03 2004-02-04 Osteotech, Inc. Osteogenic implants derived from bone
US7018416B2 (en) 2000-07-06 2006-03-28 Zimmer Spine, Inc. Bone implants and methods
US9387094B2 (en) 2000-07-19 2016-07-12 Warsaw Orthopedic, Inc. Osteoimplant and method of making same
DK177997B1 (en) 2000-07-19 2015-02-23 Ed Geistlich Söhne Ag Für Chemische Ind Bone material and collagen combination for healing of damaged joints
ATE277174T1 (en) * 2000-07-20 2004-10-15 Univ Texas STIMULATION OF CARTILAGE GROWTH WITH AGONISTS OF THE NON-PROTEOLYTICALLY ACTIVATED THROMBIN RECEPTOR
US6440141B1 (en) 2000-07-24 2002-08-27 Oratec Interventions, Inc. Method and apparatus for treating osteochondral pathologies
US9452238B2 (en) 2000-07-29 2016-09-27 Smith & Nephew LLP Tissue implant
US8366787B2 (en) 2000-08-04 2013-02-05 Depuy Products, Inc. Hybrid biologic-synthetic bioabsorbable scaffolds
DE10042484A1 (en) 2000-08-29 2002-03-28 Merck Patent Gmbh Preparing human cartilage implants, useful for repairing damaged joints, comprises culturing autologous chondrocytes in alginate gel at reduced oxygen partial pressure
WO2002018546A2 (en) 2000-09-01 2002-03-07 Virginia Commonwealth University Intellectual Property Foundation Plasma-derived-fibrin-based matrices and tissue
IL138529A0 (en) 2000-09-18 2003-09-17 Yeda Res & Dev High level expression of heterologous proteins
US6432436B1 (en) 2000-10-03 2002-08-13 Musculoskeletal Transplant Foundation Partially demineralized cortical bone constructs
US7548865B2 (en) * 2000-10-20 2009-06-16 Arthrex, Inc. Method of selling procedure specific allografts and associated instrumentation
IL139380A0 (en) 2000-10-31 2001-11-25 Prochon Biotech Ltd Active variants of fibroblast growth factor
AU2002245092A1 (en) * 2000-12-08 2002-07-30 Todd M. Boyce Implant for orthopedic applications
CA2365376C (en) 2000-12-21 2006-03-28 Ethicon, Inc. Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
WO2002053193A2 (en) 2001-01-02 2002-07-11 The Charles Stark Draper Laboratory, Inc. Tissue engineering of three-dimensional vascularized using microfabricated polymer assembly technology
US6838440B2 (en) 2001-01-24 2005-01-04 Collagen Nutraceuticals, Inc. Kolla2-desiccated avian sternal cartilage powder
WO2002060315A2 (en) * 2001-01-30 2002-08-08 Orthogene, Inc. Compositions and methods for the treatment and repair of defects or lesions in articular cartilage using synovial-derived tissue or cells
CA2438033A1 (en) 2001-02-14 2002-08-22 Osteotech, Inc. Implant derived from bone
WO2002098332A1 (en) 2001-02-16 2002-12-12 Sulzer Spine-Tech Inc. Bone implants and methods
US20030050709A1 (en) 2001-02-23 2003-03-13 Ulrich Noth Trabecular bone-derived human mesenchymal stem cells
US6575986B2 (en) 2001-02-26 2003-06-10 Ethicon, Inc. Scaffold fixation device for use in articular cartilage repair
US6743232B2 (en) 2001-02-26 2004-06-01 David W. Overaker Tissue scaffold anchor for cartilage repair
US6855169B2 (en) 2001-02-28 2005-02-15 Synthes (Usa) Demineralized bone-derived implants
IL141813A (en) 2001-03-05 2010-04-15 Hadasit Med Res Service Mixture comprising bone marrow cells together with demineralized and/or mineralized bone matrix and uses thereof in the preparation of compositions for the treatment of hematopoietic dusirders
US6995013B2 (en) 2002-07-08 2006-02-07 Biomed Solutions, Llc Cell-scaffold composition containing five layers
US7252982B2 (en) 2001-03-15 2007-08-07 Massachusetts Institute Of Technology Tissue engineering enhanced by the transfer of a growth factor gene
EP2522304B1 (en) 2001-03-23 2014-01-08 Histogenics Corporation Composition and methods for the production of biological tissues and tissue constructs
US20040151705A1 (en) 2002-03-22 2004-08-05 Shuichi Mizuno Neo-cartilage constructs and a method for preparation thereof
US20030008820A1 (en) 2001-03-27 2003-01-09 Massachusetts Institute Of Technology Methods and products related to FGF dimerization
MXPA03010616A (en) 2001-05-21 2004-04-02 Omrix Biopharm Sa Removal of plasmin(ogen) from protein solutions.
JP2005504563A (en) 2001-05-25 2005-02-17 イメージング セラピューティクス，インコーポレーテッド Methods and compositions for resurfacing joints
GB0115320D0 (en) * 2001-06-22 2001-08-15 Univ Nottingham Matrix
US6626950B2 (en) * 2001-06-28 2003-09-30 Ethicon, Inc. Composite scaffold with post anchor for the repair and regeneration of tissue
US6824547B2 (en) 2001-07-13 2004-11-30 Pilling Weck Incorporated Endoscopic clip applier and method
WO2003007790A2 (en) 2001-07-16 2003-01-30 Depuy Products, Inc. Hybrid biologic/synthetic porous extracellular matrix scaffolds
US7163563B2 (en) * 2001-07-16 2007-01-16 Depuy Products, Inc. Unitary surgical device and method
AU2002313694B2 (en) 2001-07-16 2007-08-30 Depuy Products, Inc. Cartilage repair apparatus and method
US8025896B2 (en) * 2001-07-16 2011-09-27 Depuy Products, Inc. Porous extracellular matrix scaffold and method
US7819918B2 (en) * 2001-07-16 2010-10-26 Depuy Products, Inc. Implantable tissue repair device
EP1416886A4 (en) * 2001-07-16 2007-04-18 Depuy Products Inc Cartilage repair and regeneration scaffold and method
EP1416866A4 (en) 2001-07-16 2007-04-18 Depuy Products Inc Devices form naturally occurring biologically derived
EP1416888A4 (en) * 2001-07-16 2007-04-25 Depuy Products Inc Meniscus regeneration device and method
US7201917B2 (en) 2001-07-16 2007-04-10 Depuy Products, Inc. Porous delivery scaffold and method
IL144446A0 (en) 2001-07-19 2002-05-23 Prochon Biotech Ltd Plasma protein matrices and methods for their preparation
AU2002355844A1 (en) 2001-08-01 2003-02-17 New York University Identification of receptor and heparin binding sites in fgf4 by structure-based mutagenesis
US8178123B2 (en) * 2001-08-29 2012-05-15 Femina Pharma Incorporated Method for augmentation of intraepithelial and systemic exposure of therapeutic agents having substrate activity for cytochrome P450 enzymes and membrane efflux systems following vaginal and oral cavity administration
US7132110B2 (en) 2001-08-30 2006-11-07 Isotis Orthobiologics, Inc. Tissue repair compositions and methods for their manufacture and use
JP2005506860A (en) * 2001-09-15 2005-03-10 ラツシユ−プレスビテリアン−セント・リユークズ・メデイカル・センター Layered cartilage tissue and engineering method thereof
US6855167B2 (en) 2001-12-05 2005-02-15 Osteotech, Inc. Spinal intervertebral implant, interconnections for such implant and processes for making
US7252987B2 (en) 2001-12-06 2007-08-07 Islet Technology, Inc. System for analysis and selection of encapsulated cellular materials
NZ534760A (en) 2002-01-23 2006-03-31 Inst Of Nutraceutical Res Pty Nutraceuticals for the treatment, protection and restoration of connective tissues
US6852331B2 (en) 2002-02-11 2005-02-08 Taipei Biotechnology Ltd., Inc. Fabrication of a cartilage implant
US6890354B2 (en) 2002-03-08 2005-05-10 Musculoskeletal Transplant Foundation Bone-tendon-bone assembly with allograft bone block and method for inserting same
WO2003079985A2 (en) 2002-03-18 2003-10-02 Carnegie Mellon University Method and apparatus for preparing biomimetic scaffold
US7468192B2 (en) 2002-03-22 2008-12-23 Histogenics Corporation Method for repair of cartilage lesions
US7537780B2 (en) 2002-03-22 2009-05-26 Histogenics Corporation Method for preparing and implanting a cartilage construct to treat cartilage lesions
NL1020426C2 (en) 2002-04-18 2003-10-21 Tno Modification of the properties of a fibrin matrix with respect to cell growth and ingrowth.
PL373554A1 (en) 2002-05-01 2005-09-05 Verigen Ag Injectable chondrocyte implant
IL149562A0 (en) 2002-05-09 2002-11-10 Prochon Ltd Fgf variants and methods for use thereof
US7931687B2 (en) 2002-05-13 2011-04-26 Articular Engineering, Llc Tissue engineered osteochondral implant
CN1309428C (en) 2002-05-13 2007-04-11 东芝陶瓷株式会社 Member for regenerating joint cartilage and process for producing the same, method of regenerating joint cartilage and artificial cartilage for transplantation
US7338492B2 (en) * 2002-05-15 2008-03-04 Linvatec Corporation Cross-pin graft fixation, instruments, and methods
US6989034B2 (en) 2002-05-31 2006-01-24 Ethicon, Inc. Attachment of absorbable tissue scaffolds to fixation devices
US7166133B2 (en) * 2002-06-13 2007-01-23 Kensey Nash Corporation Devices and methods for treating defects in the tissue of a living being
US7291179B2 (en) 2002-06-24 2007-11-06 Wright Medical Technology, Inc. Bone graft substitute composition
US7622562B2 (en) 2002-06-26 2009-11-24 Zimmer Orthobiologics, Inc. Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue
US20040166169A1 (en) 2002-07-15 2004-08-26 Prasanna Malaviya Porous extracellular matrix scaffold and method
US7264634B2 (en) 2002-09-20 2007-09-04 Arthrex, Inc. Method and instrumentation for osteochondral repair using preformed implants
US20040062753A1 (en) 2002-09-27 2004-04-01 Alireza Rezania Composite scaffolds seeded with mammalian cells
US7323011B2 (en) 2002-10-18 2008-01-29 Musculoskeletal Transplant Foundation Cortical and cancellous allograft cervical fusion block
US7824701B2 (en) * 2002-10-18 2010-11-02 Ethicon, Inc. Biocompatible scaffold for ligament or tendon repair
US20040078090A1 (en) 2002-10-18 2004-04-22 Francois Binette Biocompatible scaffolds with tissue fragments
US6761739B2 (en) * 2002-11-25 2004-07-13 Musculoskeletal Transplant Foundation Cortical and cancellous allograft spacer
AT500418B1 (en) 2002-12-05 2009-12-15 Winkler Heinz Dr CULTIVATED CELLULAR CELLS CONTAINING THE IMPLANT AND METHOD FOR THE PRODUCTION THEREOF
AU2004208038B2 (en) 2003-01-30 2007-09-06 Prochon Biotech Ltd. Freeze-dried fibrin matrices and methods for preparation thereof
US7985414B2 (en) 2003-02-04 2011-07-26 Warsaw Orthopedic, Inc. Polyurethanes for osteoimplants
EP1444995A1 (en) 2003-02-06 2004-08-11 Institut National De La Sante Et De La Recherche Medicale (Inserm) FGF-2 derived proteins for the preparation of biomaterials or medical devices such as stents
ES2405080T3 (en) 2003-02-26 2013-05-30 Zimmer Orthobiologics, Inc. Prepared for the repair of a cartilaginous tissue, in particular of articular cartilage defects
US7642092B2 (en) 2003-03-03 2010-01-05 Technion Research & Development Foundation Ltd. Cultured cartilage/bone cells/tissue, method of generating same and uses thereof
US7125423B2 (en) 2003-03-31 2006-10-24 Depuy Products, Inc. Intercalary prosthesis, kit and method
US20050222687A1 (en) 2004-04-02 2005-10-06 Gordana Vunjak-Novakovic Cartilage implant assembly and method for implantation
US7067123B2 (en) 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US20050064042A1 (en) 2003-04-29 2005-03-24 Musculoskeletal Transplant Foundation Cartilage implant plug with fibrin glue and method for implantation
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US20090291112A1 (en) 2003-05-16 2009-11-26 Truncale Katherine G Allograft osteochondral plug combined with cartilage particle mixture
US7488348B2 (en) 2003-05-16 2009-02-10 Musculoskeletal Transplant Foundation Cartilage allograft plug
US7537617B2 (en) 2003-06-05 2009-05-26 Warsaw Orthopedic, Inc. Bone strip implants and method of making same
US20070067032A1 (en) * 2003-06-27 2007-03-22 Felt Jeffrey C Meniscus preserving implant method and apparatus
CA2533259C (en) 2003-07-21 2014-01-28 Lifecell Corporation Acellular tissue matrices made from galactose .alpha.-1,3-galactose-deficient tissue
ATE528026T1 (en) * 2003-07-31 2011-10-15 Yukihide Iwamoto METHOD FOR PRODUCING AN ARTIFICIAL JOINT
AU2004262451B2 (en) 2003-08-12 2009-11-26 Tigenix N.V. Use of CXCL6 chemokine in the prevention or repair of cartilage defects
US20050043814A1 (en) * 2003-08-20 2005-02-24 Akihiko Kusanagi Acellular matrix implanted into an articular cartilage or osteochondral lesion protected with a biodegradable polymer modified to have extended polymerization time and methods for preparation and use thereof
US7217294B2 (en) * 2003-08-20 2007-05-15 Histogenics Corp. Acellular matrix implants for treatment of articular cartilage, bone or osteochondral defects and injuries and method for use thereof
US7226482B2 (en) 2003-09-02 2007-06-05 Synthes (U.S.A.) Multipiece allograft implant
KR101226811B1 (en) 2003-09-05 2013-01-28 신세스 게엠바하 Bone cement compositions having fiber-reinforcement and/or increased flowability
US20050065613A1 (en) * 2003-09-24 2005-03-24 Gross Jeffrey M. Reinforced fusion implant
WO2005032473A2 (en) 2003-10-02 2005-04-14 Depuy Spine, Inc. Chemical treatment for removing cellular and nuclear material from naturally occurring extracellular matrix-based biomaterials
US20050074476A1 (en) 2003-10-03 2005-04-07 El Gendler Cartilidge and bone induction by artificially perforated organic bone matrix augmented by undifferentiated cells suspended in bone gel
EP1526760A1 (en) 2003-10-21 2005-04-27 IEE INTERNATIONAL ELECTRONICS &amp; ENGINEERING S.A. Multiple electroluminescent lamp driver
GB0325141D0 (en) 2003-10-28 2003-12-03 Xiros Plc Repair of damaged tissue on a bone site
EP1686923A1 (en) * 2003-11-18 2006-08-09 Quantum Orthopedics Osteoconductive integrated spinal cage and method of making same
US7157428B2 (en) * 2003-11-26 2007-01-02 Histogenics, Corp. Method for treatment and repair of meniscal injuries
US7316822B2 (en) 2003-11-26 2008-01-08 Ethicon, Inc. Conformable tissue repair implant capable of injection delivery
US7901461B2 (en) 2003-12-05 2011-03-08 Ethicon, Inc. Viable tissue repair implants and methods of use
US7666230B2 (en) 2003-12-08 2010-02-23 Depuy Products, Inc. Implant device for cartilage regeneration in load bearing articulation regions
WO2005058207A1 (en) * 2003-12-11 2005-06-30 Isto Technologies, Inc. Particulate cartilage system
US11395865B2 (en) 2004-02-09 2022-07-26 DePuy Synthes Products, Inc. Scaffolds with viable tissue
US20050196460A1 (en) * 2004-03-08 2005-09-08 Malinin Theodore I. Particulate cartilage compositions, processes for their preparation and methods for regenerating cartilage
US20070185585A1 (en) 2004-03-09 2007-08-09 Brat Bracy Implant Scaffold Combined With Autologous Tissue, Allogenic Tissue, Cultured Tissue, or combinations Thereof
CA2555586A1 (en) 2004-03-09 2005-09-22 Osteobiologics, Inc. Implant scaffold combined with autologous or allogenic tissue
US7648965B2 (en) 2004-05-14 2010-01-19 Unigene Laboratories Inc. Method for fostering bone formation and preservation
US7531518B2 (en) 2004-05-14 2009-05-12 Unigene Laboratories Inc. Method for fostering bone formation and preservation
ES2245879B1 (en) * 2004-05-21 2006-12-16 Universidad De Malaga COMPOSITION FOR OSEA OR CARTILAGINOUS REPAIR.
US20050288796A1 (en) 2004-06-23 2005-12-29 Hani Awad Native soft tissue matrix for therapeutic applications
US7406210B2 (en) 2004-06-28 2008-07-29 Xerox Corporation Darkness control using pattern matching
US7335508B2 (en) 2004-07-22 2008-02-26 Prochon Biotech Ltd. Porous plasma protein matrices and methods for preparation thereof
CA2569736A1 (en) 2004-08-20 2006-03-02 Russell Anderson Methods of administering microparticles combined with autologous body components
WO2006036681A2 (en) 2004-09-22 2006-04-06 Cartilix, Inc. Cartilage filling device
US8043315B2 (en) * 2004-09-23 2011-10-25 Arthrex, Inc. Osteochondral repair using plug fashioned from partial distal allograft femur or condyle
US7273756B2 (en) 2004-10-01 2007-09-25 Isto Technologies, Inc. Method for chondrocyte expansion with phenotype retention
US20090149893A1 (en) 2007-12-05 2009-06-11 Semler Eric J Cancellous Bone Implant for Cartilage Repair
US20080220044A1 (en) 2007-03-06 2008-09-11 Semler Eric J Cancellous construct with support ring for repair of osteochondral defects
US7837740B2 (en) * 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US20060111778A1 (en) 2004-10-29 2006-05-25 Michalow Alexander E Methods of promoting healing of cartilage defects and method of causing stem cells to differentiate by the articular chondrocyte pathway
AU2005311977A1 (en) 2004-11-30 2006-06-08 Osteobiologics, Inc. Implants and delivery system for treating defects in articulating surfaces
SE0403020D0 (en) * 2004-12-13 2004-12-13 Rickard Braanemark Implant
EP1883398A4 (en) * 2005-02-01 2012-06-06 Osteobiologics Inc Method and device for selective addition of a bioactive agent to a multi-phase implant
US7621963B2 (en) 2005-04-13 2009-11-24 Ebi, Llc Composite bone graft material
US7291169B2 (en) 2005-04-15 2007-11-06 Zimmer Technology, Inc. Cartilage implant
EP1868539A2 (en) 2005-04-15 2007-12-26 Musculoskeletal Transplant Foundation Vertebral disc repair
US8506646B2 (en) 2005-04-29 2013-08-13 Warsaw Orthopedic, Inc. Multi-purpose medical implant devices
US20060247790A1 (en) 2005-04-30 2006-11-02 Mckay William F Shaped osteochondral grafts and methods of using same
US20060251631A1 (en) 2005-05-05 2006-11-09 Isto Technologies, Inc. Treatment of joint disease, methods and apparatuses therefor
US8092548B2 (en) * 2005-06-22 2012-01-10 Warsaw Orthopedic, Inc. Osteograft treatment to promote osteoinduction and osteograft incorporation
US7815926B2 (en) 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
US20070010824A1 (en) 2005-07-11 2007-01-11 Hugues Malandain Products, systems and methods for delivering material to bone and other internal body parts
US7622438B1 (en) 2005-07-18 2009-11-24 Acologix, Inc. Protein formulation for promoting hard tissue formation
US20070026030A1 (en) * 2005-07-27 2007-02-01 Berkeley Advanced Biomaterials, Inc. Method of preparing rheological materials for bone and cartilage repair
EP1916964A4 (en) 2005-08-26 2015-11-04 Zimmer Inc Implants and methods for repair, replacement and treatment of joint disease
US7927630B2 (en) 2005-09-12 2011-04-19 Johnson Lanny L Use of autologous sediment from fluid aspirates as vehicles for drug delivery
AU2006292224B2 (en) 2005-09-19 2013-08-01 Histogenics Corporation Cell-support matrix and a method for preparation thereof
US9132208B2 (en) 2008-08-07 2015-09-15 Lifenet Health Composition for a tissue repair implant and methods of making the same
US8029575B2 (en) * 2005-10-25 2011-10-04 Globus Medical, Inc. Porous and nonporous materials for tissue grafting and repair
US7371260B2 (en) * 2005-10-26 2008-05-13 Biomet Sports Medicine, Inc. Method and instrumentation for the preparation and transplantation of osteochondral allografts
US8403985B2 (en) * 2005-11-02 2013-03-26 Zimmer, Inc. Joint spacer implant
TWI274591B (en) * 2005-11-07 2007-03-01 Univ Tsinghua Composite scaffold for remedying articular cartilage tissue and preparation thereof
EP1951158A4 (en) * 2005-11-21 2010-03-31 Vertegen Inc Devices and methods for treating facet joints, uncovertebral joints, costovertebral joints and other joints
CA2631520A1 (en) * 2005-12-07 2007-06-14 Isto Technologies, Inc. Cartilage repair methods
US20070129630A1 (en) 2005-12-07 2007-06-07 Shimko Daniel A Imaging method, device and system
TWI316860B (en) 2005-12-29 2009-11-11 Ind Tech Res Inst Multi-layered matrix, method of tissue repair using the same and multi-layered implant prepared thereof
US8070810B2 (en) 2006-01-12 2011-12-06 Histogenics Corporation Method for repair and reconstruction of ruptured ligaments or tendons and for treatment of ligament and tendon injuries
US7833269B2 (en) 2006-01-25 2010-11-16 Warsaw Orthopedic, Inc Osteochondral implant procedure
US20070179607A1 (en) 2006-01-31 2007-08-02 Zimmer Technology, Inc. Cartilage resurfacing implant
DE102006006904A1 (en) 2006-02-09 2007-08-23 Universität Rostock New haemostatic agents and adhesives for medical applications
US7416889B2 (en) 2006-04-27 2008-08-26 Rhode Island Hospital Methods and compositions for repairing cartilage
US7838022B2 (en) 2006-05-01 2010-11-23 Warsaw Orthopedic, Inc Malleable implants containing demineralized bone matrix
US20070276506A1 (en) 2006-05-25 2007-11-29 Biomet Manufacturing Corp. Demineralized osteochondral plug
US20070299517A1 (en) 2006-06-21 2007-12-27 Howmedica Osteonics Corp. Articular cartilage implant
EP2076220A2 (en) 2006-07-25 2009-07-08 Musculoskeletal Transplant Foundation Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation
CN101332314B (en) 2008-07-22 2012-11-14 广东冠昊生物科技股份有限公司 Biotype articular cartilage repair piece
US20080039954A1 (en) 2006-08-08 2008-02-14 Howmedica Osteonics Corp. Expandable cartilage implant
US9066994B2 (en) * 2006-08-31 2015-06-30 Warsaw Orthopedic, Inc. Demineralized cancellous strip DBM graft
US8449622B2 (en) 2006-09-11 2013-05-28 Warsaw Orthopedic, Inc. Multi-phase osteochondral implantable device
EP2083846B1 (en) 2006-09-28 2015-07-15 Hepacore Ltd. N-terminal fgf variants having increased receptor selectivity and uses thereof
WO2008045212A2 (en) 2006-10-06 2008-04-17 Kyphon Sarl Products and methods for percutaneous material delivery
GB0623065D0 (en) 2006-11-18 2006-12-27 Smith & Nephew Annular ring
US20080125863A1 (en) 2006-11-28 2008-05-29 Mckay William F Implant designs and methods of improving cartilage repair
US20080138414A1 (en) * 2006-12-08 2008-06-12 Smith & Nephew, Inc. Methods of Regenerating Cartilage
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
US20080154372A1 (en) * 2006-12-21 2008-06-26 Peckham Steven M Osteochondral implant using a growth factor concentration gradient for repair of bone and cartilage tissue
WO2008081463A2 (en) 2007-01-04 2008-07-10 Hepacore Ltd. Water soluble reactive derivatives of carboxy polysaccharides and fibrinogen conjugates thereof
US7758643B2 (en) * 2007-02-26 2010-07-20 Biomet Sports Medicine, Llc Stable cartilage defect repair plug
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
US20090012629A1 (en) 2007-04-12 2009-01-08 Isto Technologies, Inc. Compositions and methods for tissue repair
US20080279825A1 (en) 2007-05-10 2008-11-13 Malinin Theodore I Cartilage material
US20080294270A1 (en) * 2007-05-24 2008-11-27 Zimmer Orthobiologics, Inc. Differentially processed tissue and processing methods thereof
US8574825B2 (en) 2007-06-01 2013-11-05 Bacterin International, Inc. Process for demineralization of bone matrix with preservation of natural growth factors
US20090024224A1 (en) * 2007-07-16 2009-01-22 Chen Silvia S Implantation of cartilage
US20090081276A1 (en) 2007-08-13 2009-03-26 Eben Alsberg Bioresorbable implant composition
US8685099B2 (en) 2007-08-14 2014-04-01 Warsaw Orthopedic, Inc. Multiple component osteoimplant
US9486317B2 (en) 2007-08-27 2016-11-08 Arthrex Inc. Method of arthroscopic osteochondral resurfacing using PRP strengthened with fibrin glue
US20090069904A1 (en) * 2007-09-12 2009-03-12 Applied Medical Research Biomaterial including micropores
US8641774B2 (en) 2007-09-14 2014-02-04 The Curators Of The University Of Missouri Synthetic osteochondral composite and method of fabrication thereof
CA2702499A1 (en) 2007-10-19 2009-04-23 Osteotech, Inc. Demineralized bone matrix compositions and methods
US8961571B2 (en) 2007-11-19 2015-02-24 David Lee Method and apparatus for spinal facet joint fusion using irregularly shaped cortical bone implants
US9700584B2 (en) * 2007-12-21 2017-07-11 Rti Surgical, Inc. Osteoinductive putties and methods of making and using such putties
CA2717725A1 (en) 2008-03-05 2009-09-11 Musculoskeletal Transplant Foundation Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
US8043375B2 (en) 2008-03-06 2011-10-25 MoiRai Orthopaedic, LLC Cartilage implants
EP2257176B1 (en) 2008-03-14 2013-09-18 Regenerative Sciences, LLC Compositions and methods for cartilage repair
JP2009291304A (en) 2008-06-03 2009-12-17 Gc Corp Bone graft substitute
US20090312842A1 (en) 2008-06-16 2009-12-17 Predrag Bursac Assembled Cartilage Repair Graft
US8608801B2 (en) 2008-07-06 2013-12-17 The Trustees Of Columbia University In The City Of New York Osteochondral implants, arthroplasty methods, devices, and systems
WO2010083051A2 (en) 2009-01-15 2010-07-22 ProChon Biotech, Ltd. Cartilage particle tissue mixtures optionally combined with a cancellous construct
US8556972B2 (en) 2009-04-02 2013-10-15 Sevika Holding AG Monolithic orthopedic implant with an articular finished surface
US8652500B2 (en) 2009-07-22 2014-02-18 Acell, Inc. Particulate tissue graft with components of differing density and methods of making and using the same
US20120283833A1 (en) 2009-12-04 2012-11-08 Brannon James K Articular cartilage treatment method
US8597317B2 (en) 2009-12-11 2013-12-03 Taipei Medical University Method for repair of articular cartilage defect and a device used therein
US9155607B2 (en) 2011-11-16 2015-10-13 Purdue Research Foundation Compositions and methods for repair or regeneration of soft tissue
US9162011B2 (en) 2011-12-19 2015-10-20 Allosource Flowable matrix compositions and methods
EP3549615B1 (en) 2011-12-20 2020-12-16 LifeCell Corporation Sheet tissue products
DK2793965T3 (en) 2011-12-20 2019-05-20 Lifecell Corp TISSUE PRODUCTS WITH FLYING DUTIES
US9198758B2 (en) 2012-01-26 2015-12-01 Warsaw Orthopedic, Inc. Delivery systems
US10207027B2 (en) 2012-06-11 2019-02-19 Globus Medical, Inc. Bioactive bone graft substitutes
US9655994B2 (en) 2012-07-25 2017-05-23 William F. McKay Delivery systems

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112704588A (en) * 2020-12-21 2021-04-27 济宁医学院附属医院 Personalized customized articular cartilage injury repair device based on 3D printing
CN112704588B (en) * 2020-12-21 2022-07-29 济宁医学院附属医院 Individualized customization articular cartilage damage prosthetic devices based on 3D prints

Also Published As

Publication number Publication date
CA2675170C (en) 2014-09-30
US7837740B2 (en) 2010-11-23
US20080255676A1 (en) 2008-10-16
WO2008106254A3 (en) 2009-07-30
WO2008106254A2 (en) 2008-09-04
US20110224797A1 (en) 2011-09-15
EP2162094A2 (en) 2010-03-17
US8906110B2 (en) 2014-12-09

Similar Documents

Publication Publication Date Title
CA2675170A1 (en) Two piece cancellous construct for cartilage repair
Kim et al. Extracellular vesicles mediate improved functional outcomes in engineered cartilage produced from MSC/chondrocyte cocultures
Xie et al. The roles of bone‐derived exosomes and exosomal micro RNA s in regulating bone remodelling
Chu et al. Strategies for annulus fibrosus regeneration: from biological therapies to tissue engineering
Cantaluppi et al. Microvesicles derived from endothelial progenitor cells enhance neoangiogenesis of human pancreatic islets
US11332757B2 (en) Delivery across cell plasma membranes
Suzuki et al. Stem cell-derived exosomes as a therapeutic tool for cardiovascular disease
Huang et al. Directing chondrogenic differentiation of mesenchymal stem cells with a solid-supported chitosan thermogel for cartilage tissue engineering
WO2006094263A3 (en) Compositions and methods for topical application and transdermal delivery of botulinum toxins
CL2011003220A1 (en) Injectable, biocompatible intraocular drug delivery system comprising a plurality of microspheres and an aqueous vehicle, wherein the microspheres consist of an alpha 2 adrenergic agonist and biodegradable polylactic acid (pla) polymers; and its use to lower intraocular pressure. (div. sol. 3464-07)
EP2471797A3 (en) 17-Desmethylrapamycin and analogues thereof, methods for their production and their use as immunosupressants, anticancer agents, antifungal agents etc.
Li et al. Effects of sequentially released BMP-2 and BMP-7 from PELA microcapsule-based scaffolds on the bone regeneration
Kowalczewski et al. Surface-mediated delivery of siRNA from fibrin hydrogels for knockdown of the BMP-2 binding antagonist noggin
Zhang et al. Bioactive borate glass promotes the repair of radius segmental bone defects by enhancing the osteogenic differentiation of BMSCs
Díaz-Rodríguez et al. Controlled release of indomethacin from alginate–poloxamer–silicon carbide composites decrease in-vitro inflammation
EP4049653A4 (en) Injectable intraocular microgel as drug delivery system, and hydrogel comprising same
Suh et al. Molecular signatures of secretomes from mesenchymal stem cells: therapeutic benefits
Lalidou et al. Bone grafts as carriers for local antibiotic delivery for the treatment and prevention of bone infections
Şahin et al. Advanced injectable alternatives for osteoarthritis
MXPA02011045A (en) Combinations of plant protection agents with anionic polymers.
GB2438144A (en) Sustained-release fragrance delivery system
CN106618796B (en) The anti-wave stent graft system of aorta
Moeinzadeh et al. Devitalized Stem Cell Microsheets for Sustainable Release of Osteogenic and Vasculogenic Growth Factors and Regulation of Anti‐Inflammatory Immune Response
Rahman et al. Evaluation of three dimensional construct engineered from poly (Lactic-coglycolic acid)/fibrin hybrid scaffold using rabbit bone marrow mesenchymal stem cells for osteochondral defect repair
Sankaranarayanan et al. Exosomes Reshape the Osteoarthritic Defect: Emerging Potential in Regenerative Medicine–A Review

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20190123