CA2563340A1 - Aspherical corneal implant - Google Patents
Aspherical corneal implant Download PDFInfo
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- CA2563340A1 CA2563340A1 CA002563340A CA2563340A CA2563340A1 CA 2563340 A1 CA2563340 A1 CA 2563340A1 CA 002563340 A CA002563340 A CA 002563340A CA 2563340 A CA2563340 A CA 2563340A CA 2563340 A1 CA2563340 A1 CA 2563340A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/142—Cornea, e.g. artificial corneae, keratoprostheses or corneal implants for repair of defective corneal tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
- A61F2/1637—Correcting aberrations caused by inhomogeneities; correcting intrinsic aberrations, e.g. of the cornea, of the surface of the natural lens, aspheric, cylindrical, toric lenses
- A61F2/164—Aspheric lenses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/147—Implants to be inserted in the stroma for refractive correction, e.g. ring-like implants
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
Abstract
A corneal implant (10) having an aspheric surface (12) for modifying the cornea curvature and altering the corneal refractive power. The corneal implant has a lens body formed of an optically clear bio-compatible material, preferably with an index of refraction substantially similar to that of human corneal tissue (1.376). The aspheric surface is comprised of a continuous aspheric surface from the apex of the implant to beveled surface (20). The beveled surface, positioned near the outer diameter of the implant, is used to reduce the thickness of the aspheric surface on the periphery of the lens to the outer diameter edge. The body of the implant has a diameter between about 2.0 mm and 7.0 mm and a thickness less than about .150 mm.
Description
ASPHERICAL CORNEAL IMPLANT
TECHNICAL FIELD
[0001] The field of this invention relates to prosthetic implants designed to be implanted in the cornea. More particularly, the invention relates to a comeal implant having an aspheric surface for modifying the cornea curvature and altering the corneal refractive power.
BACKGROUND OF THE INVENTION
TECHNICAL FIELD
[0001] The field of this invention relates to prosthetic implants designed to be implanted in the cornea. More particularly, the invention relates to a comeal implant having an aspheric surface for modifying the cornea curvature and altering the corneal refractive power.
BACKGROUND OF THE INVENTION
[0002] Normal vision occurs when light that passes through and is refracted by the corn.ea, the lens, and other portions of the eye, and converges at or near the retina. Myopia or near-sightedness occurs when the light converges at a point before it reaches the retina and, conversely, hyperopia or far-sightedness occurs when the light converges a point beyond the retina. Other abnormal conditions include astigmatism where the outer surface of the cornea is irregular in shape and effects the ability of light to be refracted by the cornea. In addition, in patients who are older, a condition called presbyopia occurs in which there is a diminished power of accommodation of the natural lens resulting from the loss of elasticity of the lens, typically becoming significant after the age of 45.
[0003] Corrections for these conditions through the use of implants within the human cornea have been suggested. Various designs for such implants include solid, ring shaped, and split-ring shaped, circular flexible body members and other types of ring-shaped devices that are adjustable. These implants are inserted within the body of the cornea for changing the shape of the cornea, thereby altering its refractive power.
[0004] Generally, the human cornea flattens away from the center. The reasons are not completely clear, though one known factor is that as the cornea flattens it reduces the spherical aberration. Therefore, I consider it desirable to reshape the cornea and maintain an aspheric surface that naturally occurs while correcting for refractive error. I believe there is a demonstrated need for a more effective corneal implant that has an aspheric surface that will correspond more naturally to the surface of the human eye to address the problems as previously discussed.
BRIEF SIM.VIARY OF THE INVENTION
BRIEF SIM.VIARY OF THE INVENTION
[0005] The present invention is directed to prosthetic implants designed to be implanted in the cornea. More particularly, the invention relates to a corneal implant having an aspheric surface for modifyin.g the cornea curvature and altering the comeal refractive power. The implant has a continuous aspheric surface extending from a center point or apex of the anterior surface of the lens body. This continuous aspheric surface preferably extends for a radius of at least 1 mm from the center or apex of the lens body. The continuous aspheric surface is continually aspheric along the surface and does not contain any portion of the aspherical surface that is spherical.
[0006] The lens body is preferably formed of an optically clear bio-compatible material.
The bio-compatible material has an index of refraction substantially similar to that of human corneal tissue (1.376). Thus, in a preferred embodiment, the refractive index of the implant material should be in the range of 1.36-1.39. Having such a refractive index prevents optical aberrations due to edge effects at the cornea-implant interface.
The bio-compatible material has an index of refraction substantially similar to that of human corneal tissue (1.376). Thus, in a preferred embodiment, the refractive index of the implant material should be in the range of 1.36-1.39. Having such a refractive index prevents optical aberrations due to edge effects at the cornea-implant interface.
[0007] The optically clear bio-compatible material is preferably made from a visually clear, permeable, microporous hydrogel with a water content greater than 40%
up to approximately 90%. Other suitable bio-compatible materials, however, may be used.
up to approximately 90%. Other suitable bio-compatible materials, however, may be used.
[0008] The lens body has an anterior surface, a posterior surface, and an outer diameter edge. The anterior surface is generally convex in shape with a continuous aspheric surface. In one embodiment, the posterior surface is concave in shape with a posterior radii of curvature.
However, the posterior surface may shaped differently, such as being substantially planar, having multiple radii of curvature, and other shapes as would be readily useful.
However, the posterior surface may shaped differently, such as being substantially planar, having multiple radii of curvature, and other shapes as would be readily useful.
[0009] In a preferred embodiment, the lens body has a thickness less than about .150 mm, an outer diameter edge thickness of about .015 mm, and a diameter between about 2.0 mm and about 7.0 mm.
[0010] The implant may be formed with a beveled surface. The beveled surface assists in maintaining the required edge thickness while increasing lens strength.
Preferably, the beveled surface has a convex shape that has a partially spherical or partially aspherical surface.
Preferably, the beveled surface has a convex shape that has a partially spherical or partially aspherical surface.
[0011] In one aspect of the invention, there is a method of implanting the various embodiments of the inventive corneal implant as described herein. The method includes the steps of (a) cutting away a portion of the outer surface of a cornea; (b) implanting a lens on the exposed surface of the cornea, the lens having a lens body formed of an optically clear, bio-compatible material, the lens body having an anterior surface and a posterior surface, and an outer diameter edge; the bio-compatible material having a refractive index ranging from 1.36-1.39, and the anterior surface being convex in shape with a continuous aspheric surface; and (c) replacing the portion of the cornea that was cut away.
[0012] The foregoing has outlined rather broadly the features and technical advantages of the present invention in order that the detailed description of the invention that follows may be better understood. Additional features and advantages of the invention will be described hereinafter which form the subject of the claims of the invention. It should be appreciated that the conception and specific embodiment disclosed may be readily utilized as a basis for modifying or designing other structures for carrying out the same purposes of the present invention. It should also be realized that such equivalent constructions- do not depart from the invention as set forth in the appended claims. The novel features which are believed to be characteristic of the invention, both as to its organization and method of operation, together with further objects and advantages will be better understood from the following description when considered in connection with the accompanying figures. It is to be expressly understood, however, that each of the figures is provided for the purpose of illustration and description only and is not intended as a definition of the limits of the present invention.
BRIEF DESCRIPTION OF THE DRAWINGS
BRIEF DESCRIPTION OF THE DRAWINGS
[0013] For a more complete understanding of the present invention, reference is now made to the following descriptions taken in conjunction with the accompanying drawing, in which:
FIG. 1A is a top of an embodiment of the corneal implant;, FIG. 1B is a 3-dimensional, cross-sectional view A-A of the implant of Figure 1A;
FIG. 1C is a 3-dimensional, cross-sectional view of the area B of Figure 1B;
FIG. 2 is a cross-sectional view illustrating the nature of an aspherical continuos surface;
FIG. 3 is a diagram showing the effect of asphericity on the shape of a concoid;
FIGS. 4A and 4B are schematic representations of a lamellar dissectomy, with FIG.
4B showing in particular the portion of the dissected cornea being connected through a hinge to the intact cornea; and FIG. 4C is a schematic representations of a cornea in which the corneal implant have been implanted.
DETAILED DESCRIPTION OF THE INVENTION
FIG. 1A is a top of an embodiment of the corneal implant;, FIG. 1B is a 3-dimensional, cross-sectional view A-A of the implant of Figure 1A;
FIG. 1C is a 3-dimensional, cross-sectional view of the area B of Figure 1B;
FIG. 2 is a cross-sectional view illustrating the nature of an aspherical continuos surface;
FIG. 3 is a diagram showing the effect of asphericity on the shape of a concoid;
FIGS. 4A and 4B are schematic representations of a lamellar dissectomy, with FIG.
4B showing in particular the portion of the dissected cornea being connected through a hinge to the intact cornea; and FIG. 4C is a schematic representations of a cornea in which the corneal implant have been implanted.
DETAILED DESCRIPTION OF THE INVENTION
[0014] As used herein, the term "a" or "an" may mean one or more. As used herein in the claim(s), when used in conjunction with the word "comprising", the words "a" or "an" may mean one or more than one. As used herein, "another" may mean at least a second or more.
[0015] As used herein, the term "mm" means the unit of measurement in millimeters.
[0016] Most current surgical procedures are just coming of age in regards to aspheric surfacing. There is considerable published data on the anterior corneal surface asphericity. The common comeal shape is either a conic in certain sections or conicoids using three-dimensional data. The results are usually expressed in terms of asphericity Q, shape factor p or the eccentricity e. The mean values of the comeal surface are in the approximate range Q = -0.2 to -0.3. One thought is that the reason the human cornea flattens is to reduce spherical aberration.
[0017] When spherical aberration is present, non-paraxial rays do not intersect at the paraxial focus. By producing a spherical surface on the eye, the amount of asphericity is reduced that the cornea has and in turn, a spherical aberration is created. In most accounts the result will be a better near visual acuity because the center rays are still basically unaffected, but the intermediate and distance can loose some visual acuity.
[0018] To decrease the spherical - aberration and also correct for visual disorders, one must look at the following. Maintain the natural aspheric surface that the cornea has, and flatten or steepen the cornea at the same time.
[0019] By doing the described, the central rays can be left as they are or increased (in the case of presbyopia) and at the same time flatten or decrease the radius from apex to the edge, bringing all rays within the paraxial focus. The actual radius is determined by what correction is needed to correct the visual disorder. All radius of curvature are dependent on the individual refraction of a patient.
[0020] Referring to Figure 1A-1B, an embodiment of the aspherical comeal implant is shown. Figure 1A is a top view of the implant. The implant 10 has a diameter (as shown by arrows 11-11) in the range of about 2.00 mm to 7.00 mm. The anterior surface 14 of the ixnplant has an aspheric surface 12 that is generally convex in shape. The aspheric surface 12 is comprised of a continuous aspheric surface from apex 18 to the transition zone 22. The transition zone 22 is the junction that begins the beveled surface 20. The beveled surface 20 is used to reduce the thickness of the aspheric surface 12 on the periphery of the lens to the outer diameter edge 24. Given that the implant 10 has a maximum useful diameter for implantation into the human cornea the implant without the beveled surface, would be too thick at the edges to properly seat the implant into the cornea. An edge thickness as specified prevents stacking and recruitment of keratocytes in the lens material so that keratocyte stacking and recruitment does not take place. This in turn eliminates unorganized collagen that forms undesirable scar tissue and infiltrates the lens, which tends to compromise the efficacy of the lens.
[0021] Referring now to Figure 1B, a 3-dimensional, cross-sectional view of the implant 10 of Figure 1A is shown. The implant 10 has an aspheric surface 12 from the apex 18 of the anterior surface of the lens to a transition zone 22. The radius of the aspheric surface 12 extends from the apex 18 outward towards the outer diameter edge 24. This radius is not less than 1.0 mm and the radius is not greater than the total radius to the beginning of the transition zone 22.
[0022] The implant 10 has a posterior surface 16 that is generally concave in shape.
Where the implant is circular in shape, the apex 18 is also the center point of the lens. In one embodiment, the lens body has a thickness (as indicated by arrows 19-19) of less than about .150 mm. The center of the lens in most cases is the thickest part of the lens.
Where the implant is circular in shape, the apex 18 is also the center point of the lens. In one embodiment, the lens body has a thickness (as indicated by arrows 19-19) of less than about .150 mm. The center of the lens in most cases is the thickest part of the lens.
[0023] In a preferred embodiment, the posterior surface 16 is concave in shape with a posterior radii of curvature. However, the posterior surface 16 may shaped differently, such as being substantially flat or planar, having multiple radii of curvature, or utilizing other shapes as would be readily useful. In these other embodiments where a different shape posterior surface is utilized, than the thickness of the implant at its center may be greater than .150 mm. However, when using a concave shaped poster surface 16, preferably the thickness should be less than about.150 mm.
[0024] Figure 1C is a close-up view of the area designated by the letter B in Figure 1B.
Preferably, the implant 10 has an outer diameter edge 24 that has substantially planar surface.
The outer diameter edge 24 surface may also be spherical, or of other shapes that would be useful. Preferably, the outer diameter edge 24 has a thickness of about .015 mm. The thickness of the outer diameter edge is illustrated by arrows 25-25.
Preferably, the implant 10 has an outer diameter edge 24 that has substantially planar surface.
The outer diameter edge 24 surface may also be spherical, or of other shapes that would be useful. Preferably, the outer diameter edge 24 has a thickness of about .015 mm. The thickness of the outer diameter edge is illustrated by arrows 25-25.
[0025] A beveled surface 20 transitions the anterior portion of the outer diameter edge 24 with the aspheric surface 12. -In one embodiment, the shape of the surface of the beveled surface is substantially spherical with a radii of curvature, but in other embodiments may be substantially aspherical, substantially planar or other of useful shapes. Preferably, where the beveled surface 20 is spherical, the beveled has a single radii of curvature. The beveled surface 20 has a radius between about radius 1.5 mm - 10.5 mm depending on the width of the implant.
The beveled surface 20 and the aspheric surface 12 intersect at a junction 22. This junction 22 is referred herein, interchangeably, as the transition zone 22. The transition zone 22 provides a smooth transition from the beveled surface 20 to the aspheric surface 12. The transition zone 22 is preferably aspheric.
The beveled surface 20 and the aspheric surface 12 intersect at a junction 22. This junction 22 is referred herein, interchangeably, as the transition zone 22. The transition zone 22 provides a smooth transition from the beveled surface 20 to the aspheric surface 12. The transition zone 22 is preferably aspheric.
[0026] In one embodiment, the aspheric surface 12 comprises a continuous aspheric surface with a Q-value of less than zero, wherein Q is the surface asphericity and Q < 0 represents a surface that flattens away from its vertex. The aspheric surface 12 may have a single Q-value or multiple Q-values for different zones on the surface of the implant, with each Q-value being less than zero. This can be expressed in terms of quantity p called the shape factor, which is related to Q by the equation p= 1+Q or as eccentricity which is related to Q by the equation Q = -e2.
Q is represented by the following equation -h2 +(1+Q)Z2-2ZR=0 where the Z axis is the optical axis, where h2 = X~ + Y2, and where X, Y are distances perpendicular to optical axis, where R is the vertex radius of curvature.
Q is the surface asphericity, where Q < -1 specifies a hyperboloid, Q = -1 specifies a paraboloid, -1 < Q< 0 specifies an ellipsoid, with the Z-axis being the major axis, Q = 0 specifies a sphere, Q> 0 specifies an ellipsoid with the major axis in the X-Y plane.
Q is represented by the following equation -h2 +(1+Q)Z2-2ZR=0 where the Z axis is the optical axis, where h2 = X~ + Y2, and where X, Y are distances perpendicular to optical axis, where R is the vertex radius of curvature.
Q is the surface asphericity, where Q < -1 specifies a hyperboloid, Q = -1 specifies a paraboloid, -1 < Q< 0 specifies an ellipsoid, with the Z-axis being the major axis, Q = 0 specifies a sphere, Q> 0 specifies an ellipsoid with the major axis in the X-Y plane.
[0027] Referring to FIG. 3, the effect of asphericity on the shape of a concoid is shown.
All of the curves have the same apex radius of curvature. The figure shows an -X,-Y, -Z axis with the particular axis labeled respectively. The general Q value equation discussed above is diagramatically illustrated in the figure: Ellipsoids, Sphere, Hyperboloids, and Paraboloids.
All of the curves have the same apex radius of curvature. The figure shows an -X,-Y, -Z axis with the particular axis labeled respectively. The general Q value equation discussed above is diagramatically illustrated in the figure: Ellipsoids, Sphere, Hyperboloids, and Paraboloids.
[0028] By varying the Q value of the aspheric surface 12, the corneal implant 10 aids in the correction of presbyopia, hyperopia, myopia or the combination thereof, while maintaining an the actual corneal surface of the eye in an aspheric manner. The following Table 1 illustrates different Q values for different lens parameters. Table 1 is merely illustrative and should not be construed to Iimit the size and ranges of the various parameters shown.
Anterior Anterior Approximant Posterior Anterior Anterior End Semi- Asphericity Diopter Change Radius Apex Radius Radius Diameter (Q) 1.25 7.500 7.147 7.508 3.820 -0.118 1.75 7.500 7.081 7.508 3.820 -0.138 2.25 7.500 7.014 7.508 3.820 -0.158 2.75 7.500 6.949 7.508 3.820 -0.176 3.25 7.500 6.884 7.508 3.820 -0.195 3.75 7.500 6.822 7.508 3.820 -0.212 4.25 7.500 6.760 7.508 3.820 -0.228 4.75 7.500 6.700 7.508 3.820 -0.244 [0029] As used in Table 1, the column labeled Approximant Diopter Change refers to the projected diopter power change from the apex (center) of the lens to transition zone of the lens when implanted into the cornea. Whereas the center value would be + 4.00 diopters the edge would have a value of 2.25 diopters less positive power. The lens anterior surface progressively changes from apex to edge. The table above is only a representative sample of diopter changes.
For example, the diopter change for the corneal implant 10 may range from .12 diopter to 10 diopters for a given implant. The particular diopter for a corneal implant 10 will depend on a given patient's corrective needs.
Anterior Anterior Approximant Posterior Anterior Anterior End Semi- Asphericity Diopter Change Radius Apex Radius Radius Diameter (Q) 1.25 7.500 7.147 7.508 3.820 -0.118 1.75 7.500 7.081 7.508 3.820 -0.138 2.25 7.500 7.014 7.508 3.820 -0.158 2.75 7.500 6.949 7.508 3.820 -0.176 3.25 7.500 6.884 7.508 3.820 -0.195 3.75 7.500 6.822 7.508 3.820 -0.212 4.25 7.500 6.760 7.508 3.820 -0.228 4.75 7.500 6.700 7.508 3.820 -0.244 [0029] As used in Table 1, the column labeled Approximant Diopter Change refers to the projected diopter power change from the apex (center) of the lens to transition zone of the lens when implanted into the cornea. Whereas the center value would be + 4.00 diopters the edge would have a value of 2.25 diopters less positive power. The lens anterior surface progressively changes from apex to edge. The table above is only a representative sample of diopter changes.
For example, the diopter change for the corneal implant 10 may range from .12 diopter to 10 diopters for a given implant. The particular diopter for a corneal implant 10 will depend on a given patient's corrective needs.
[0030] The column labeled Posterior Radius refers to the back surface of the lens having contact with the stromal bed. The value for the Posterior Radius as used in Table 1 is measured in millimeters. Table 1 illustrates utilizing a posterior radius of 7.5 mm for each of the listed implants. The posterior radius may be varied depending on the particular posterior radius desired. In other embodiments, the posterior surface does not have a posterior radius of curvature, but is instead flat or has some other shaped surface or is textured.
[0031] The column labeled Anterior Apex Radius refers to the radius at the optical axis, or apex (center) in millimeters, needed to achieve desired corneal shape.
[0032] The column labeled Anterior End Radius refers to the target radius in millimeters at the end of the aspheric zone or outside diameter of said zone needed to achieve desired comeal shape.
[0033] The column labeled Anterior Semi-Diameter refers to the diameter of the desired aspheric zone measured in milli meters.
[0034] The column labeled Anterior Asphericity is the resultant Q value. In the examples shown in Table 1, the resultant Q value indicates that the anterior aspheric surface of the lens has a an aspheric ellipsoidal shape.
[0035] Referring now to Figure 2, an example of an aspheric surface is shown.
Line 23 is perpendicular to line 25. Point 26 is on line 23 which passes through the apex of the implant 10. Figure 2 is not drawn completely to. scale, but nevertheless illustrates the nature of the aspheric surface. The radius from point 26 to the surface indicated by arrow 30 is a radius of 6.6961 mm. The radius from point 26 to the surface indicated by arrow 31 is a radius of 6.7196.
The follow Table 2 shows the remaining indicated radii from point 26.
Arrow Radii in mm 32 6.7432 33 6.7683 34 6.7918 35 6.8154 36 6.8389 37 6.8640 38 6.8876 39 6.9111 40 6.9410 [0036] The particular points of the aspheric surface 12 show in Figure 2 that the radii of curvature from point 26 increases from the apex 18 as the surface moves towards the outer edge of the implant. In a normal spherical surface, a lens would have a constant radii of curvature along the surface of the lens. As shown in Figure 2, the inventive corneal implant 10 does not have a spherical surface, but instead a continuous aspheric surface from the apex of the implant.
[00371 The corneal implant 10 with the aspheric when implant is designed to reshape or re-contour the surface of the cornea by steepening or flattening the overall radius of curvature of the human cornea, while maintaining the correct natural aspheric surface.
[0038] Tn various embodiment, the comeal implant 10 with the aspheric surface can simultaneously correct the refractive error for distance vision (farsighted) and correct for near vision (reading). To achieve this, additional power is added to the central portion of the lens to correct the (reading add). For example, a patient with a refractive error of +3.00 diopters for distance, a positive 2 diopters is added to this needed distance correction for reading. This calculates to a starting diopter power at the apex of the comeal implant of +5.00 diopters which will progressively change to +3.00 diopters at the outer edge.
[0039] Taking the +5.00 diopters at apex the Q value can be calculated that is required to bring the lens surface (or cornea) from +5.00 diopters to +3.00 diopters within a designed lens diameter. An example would be to set the apex start at +5.00 and reduce the amount of aspheric change to within only 2.00 mm of the central portion of the lens. This result would then set this area of the lens to change progressively from +5.00 diopter to +4.50 diopters.
From this point of 2.00 mm to 5.00 mm (remainder of lens) the asphericity can be set at a value to bring the remainder of the lens progressively from the +4.50 diopter to the required +3.00 diopter that the patient needed for distance correction. With this aspheric re-contouring using the inventive comeal implant 10, progressive change can be made which follow the natural shape of the human cornea.
[0040] The corneal implant 10 has a lens body formed of an optically clear bio-compatible material. In a preferred embodiment, the bio-compatible material has an index of refraction substantially similar to that of human corneal tissue (1.376).
Thus, in a preferred embodiment, the refractive index of the implant material should be in the range of 1.36-1.39.
Having such a refractive index prevents optical aberrations due to edge effects at the cornea-implant interface.
Line 23 is perpendicular to line 25. Point 26 is on line 23 which passes through the apex of the implant 10. Figure 2 is not drawn completely to. scale, but nevertheless illustrates the nature of the aspheric surface. The radius from point 26 to the surface indicated by arrow 30 is a radius of 6.6961 mm. The radius from point 26 to the surface indicated by arrow 31 is a radius of 6.7196.
The follow Table 2 shows the remaining indicated radii from point 26.
Arrow Radii in mm 32 6.7432 33 6.7683 34 6.7918 35 6.8154 36 6.8389 37 6.8640 38 6.8876 39 6.9111 40 6.9410 [0036] The particular points of the aspheric surface 12 show in Figure 2 that the radii of curvature from point 26 increases from the apex 18 as the surface moves towards the outer edge of the implant. In a normal spherical surface, a lens would have a constant radii of curvature along the surface of the lens. As shown in Figure 2, the inventive corneal implant 10 does not have a spherical surface, but instead a continuous aspheric surface from the apex of the implant.
[00371 The corneal implant 10 with the aspheric when implant is designed to reshape or re-contour the surface of the cornea by steepening or flattening the overall radius of curvature of the human cornea, while maintaining the correct natural aspheric surface.
[0038] Tn various embodiment, the comeal implant 10 with the aspheric surface can simultaneously correct the refractive error for distance vision (farsighted) and correct for near vision (reading). To achieve this, additional power is added to the central portion of the lens to correct the (reading add). For example, a patient with a refractive error of +3.00 diopters for distance, a positive 2 diopters is added to this needed distance correction for reading. This calculates to a starting diopter power at the apex of the comeal implant of +5.00 diopters which will progressively change to +3.00 diopters at the outer edge.
[0039] Taking the +5.00 diopters at apex the Q value can be calculated that is required to bring the lens surface (or cornea) from +5.00 diopters to +3.00 diopters within a designed lens diameter. An example would be to set the apex start at +5.00 and reduce the amount of aspheric change to within only 2.00 mm of the central portion of the lens. This result would then set this area of the lens to change progressively from +5.00 diopter to +4.50 diopters.
From this point of 2.00 mm to 5.00 mm (remainder of lens) the asphericity can be set at a value to bring the remainder of the lens progressively from the +4.50 diopter to the required +3.00 diopter that the patient needed for distance correction. With this aspheric re-contouring using the inventive comeal implant 10, progressive change can be made which follow the natural shape of the human cornea.
[0040] The corneal implant 10 has a lens body formed of an optically clear bio-compatible material. In a preferred embodiment, the bio-compatible material has an index of refraction substantially similar to that of human corneal tissue (1.376).
Thus, in a preferred embodiment, the refractive index of the implant material should be in the range of 1.36-1.39.
Having such a refractive index prevents optical aberrations due to edge effects at the cornea-implant interface.
[0041] The corneal implant 10 is preferably made from a visually clear, permeable, microporous hydrogel with a water content greater than 40% up to approximately 90%. In other embodiments, the refractive index may be different from the refractive index of the corneal tissue. In such embodiments, in addition to the change in the shape of the cornea caused by the implantation of the lens, the actual material would have a refractive effect.
Other embodiments from which the corneal implant may be made, include: polymethimethacrylate (PMMA), silicone polymers, UV-absorbing acrylic, hydrogel, microporous hydrogel, collamer, collagel acrylic polymers, and other composite materials.
Other embodiments from which the corneal implant may be made, include: polymethimethacrylate (PMMA), silicone polymers, UV-absorbing acrylic, hydrogel, microporous hydrogel, collamer, collagel acrylic polymers, and other composite materials.
[0042] The present comeal implant 10 can be implanted in the cornea using a lamellar dissectomy shown schematically in FIGS. 4A, 4B. In this procedure, a keratome (not shown) is used in a known way to cut a portion of the outer surface of the cornea along line 42 as shown in FIG. 4A. This type of cut is used to form a corneal flap 44 shown in FIG. 4B, which remains attached to the corn.ea 40 through what is called a hinge 46. The hinge 46 is useful for allowing the flap 44 to be replaced with the same orientation as before the cut.
[0043] As is also known in the art, the flap is cut deeply enough to dissect the Bowman's membrane portion of the cornea, such as in keratome surgery or for subsequent moving of the tissue by laser or surgical removal. Other known techniques of cutting a flap in the cornea, such a utilizing a laser to create a flap or a pocket in which to place the implant, may also be used. A
comeal flap of 100 to 200 microns, typically 160 to 200 microns, is made to eliminate the Bowman's membrane tension (which minimizes comeal nerve damage). This helps to conform the flap to the lens surface, thereby transferring all of the change of the shape to the anterior surface of the cornea. This makes refractive correction more reliable and predictable. Also, the possibility of extrusion of the implants is reduced due to pressure generated within the cornea caused by the addition of the implant. The comeal implant 10 is shown implanted in the cornea in FIG. 4C respectively, after the flap has been replaced in its normal position. These figures show the corrected shape for the outer surface of the comea as a result of implants of the shapes described.
[00441 Although the present invention and its advantages have been described in detail, it should be understood that various changes, substitutions and alterations can be made herein without departing from the invention as defined by the appended claims.
Moreover, the scope of the present application is not intended to be limited to the particular embodiments of the process, mac_hine, manufacture, composition of matter, means, methods and steps described in the specification. As one will readily appreciate from the disclosure, processes, machines, manufacture, compositions of matter, means, methods, or steps, presently existing or later to be developed that perform substantially the same function or achieve substantially the same result as the corresponding embodiments described herein may be utilized.
Accordingly, the appended claims are intended to include within their scope such processes, machines, manufacture, compositions of matter, means, methods, or steps.
comeal flap of 100 to 200 microns, typically 160 to 200 microns, is made to eliminate the Bowman's membrane tension (which minimizes comeal nerve damage). This helps to conform the flap to the lens surface, thereby transferring all of the change of the shape to the anterior surface of the cornea. This makes refractive correction more reliable and predictable. Also, the possibility of extrusion of the implants is reduced due to pressure generated within the cornea caused by the addition of the implant. The comeal implant 10 is shown implanted in the cornea in FIG. 4C respectively, after the flap has been replaced in its normal position. These figures show the corrected shape for the outer surface of the comea as a result of implants of the shapes described.
[00441 Although the present invention and its advantages have been described in detail, it should be understood that various changes, substitutions and alterations can be made herein without departing from the invention as defined by the appended claims.
Moreover, the scope of the present application is not intended to be limited to the particular embodiments of the process, mac_hine, manufacture, composition of matter, means, methods and steps described in the specification. As one will readily appreciate from the disclosure, processes, machines, manufacture, compositions of matter, means, methods, or steps, presently existing or later to be developed that perform substantially the same function or achieve substantially the same result as the corresponding embodiments described herein may be utilized.
Accordingly, the appended claims are intended to include within their scope such processes, machines, manufacture, compositions of matter, means, methods, or steps.
Claims (63)
1. A corneal implant, comprising:
a lens body formed of an optically clear, bio-compatible material, the lens body having an anterior surface and a posterior surface, and an outer diameter edge;
the bio-compatible material having a refractive index ranging from 1.36-1.39;
and the anterior surface being convex in shape with a continuous aspheric surface.
a lens body formed of an optically clear, bio-compatible material, the lens body having an anterior surface and a posterior surface, and an outer diameter edge;
the bio-compatible material having a refractive index ranging from 1.36-1.39;
and the anterior surface being convex in shape with a continuous aspheric surface.
2. The implant of claim 1, wherein the posterior surface is concave in shape.
3. The implant of claim 2, wherein the posterior surface is curved in shape with a posterior radii of curvature.
4. The implant of claim 1, wherein the lens body has a thickness less than about.150 mm.
5. The implant of claim 1, wherein the lens body has a diameter between about 2.0 mm and about 7.0 mm..
6. The implant of claim 1, wherein the outer diameter edge has a thickness less than about .015 mm.
7. The implant of claim 1, wherein the outer diameter edge has a substantially planar surface.
8. The implant of claim 1, wherein the aspheric surface is adapted for the correction of presbyopia.
9. The implant of claim 1, wherein the aspheric surface is adapted for the correction of hyperopia.
10. The implant of claim 1, wherein the aspheric surface is adapted for the correction of myopia.
11. The implant of claim 1, wherein the lens body has a beveled surface connecting the outer diameter edge and the aspheric surface.
12. The implant of claim 11, wherein the beveled surface has a convex shape.
13. The implant of claim 12, wherein the convex shape has a partially spherical or aspherical surface.
14. The implant of claim 11, wherein the beveled surface is substantially planar.
15. The implant of claim 11, wherein the lens body has a center point, and the continuous 'aspheric surface extends from the center point for a radius of at least 1.0 mm.
16. The implant of claim 1, wherein the lens body has an apex, and the continuous aspheric surface extends from the apex to the beveled surface.
17. The implant of claim 1, wherein the lens body is circular in shape.
18. The implant of claim 1, wherein the optically clear, bio-compatible material is a permeable, microporous hydrogel.
19. The implant of claim 1, wherein then microporous hydrogel has a water content greater than 40% and up to approximately 90%.
20. The implant of claim 1, wherein the aspheric surface is defined by the formula: h2 +(l+Q)Z2 - 2ZR = 0, wherein the Z axis is the optical axis, wherein ha = Y + Y2, wherein R is the vertex radius of curvature, and wherein Q is the surface asphericity and Q < 0.
21. A corneal implant, comprising:
a lens body formed of an optically clear, bio-compatible material, the lens body having an anterior surface and a posterior surface, and an outer diameter edge, the outer diameter edge having a thickness less than about .015 mm, the lens body having a diameter between about 2.0 mm and 7.0 mm;
the bio-compatible material having a refractive index ranging from 1.36-1.39;
the anterior surface being convex in shape with a continuous aspheric surface;
and the lens body having a beveled surface connecting the outer diameter edge and the aspheric surface.
a lens body formed of an optically clear, bio-compatible material, the lens body having an anterior surface and a posterior surface, and an outer diameter edge, the outer diameter edge having a thickness less than about .015 mm, the lens body having a diameter between about 2.0 mm and 7.0 mm;
the bio-compatible material having a refractive index ranging from 1.36-1.39;
the anterior surface being convex in shape with a continuous aspheric surface;
and the lens body having a beveled surface connecting the outer diameter edge and the aspheric surface.
22. The implant of claim 21, wherein the posterior surface is concave in shape.
23. The implant of claim 22, wherein the posterior surface is curved in shape with a posterior radii of curvature.
24. The implant of claim 21, wherein the aspheric surface is adapted for the correction of presbyopia.
25. The implant of claim 21, wherein the aspheric surface is adapted for the correction of hyperopia.
26. The implant of claim 21, wherein the aspheric surface is adapted for the correction of myopia.
27. The implant of claim 21, wherein the beveled surface has a convex shape.
28. The implant of claim 27, wherein the convex shape has a partially spherical or aspherical surface.
29. The implant of claim 21, wherein the beveled surface is substantially planar.
30. The implant of claim 21, wherein the lens body has an apex, and the continuous aspheric surface extends from the apex to the beveled surface.
31. The implant of claim 21, wherein the lens body is circular in shape.
32. The implant of claim 21, wherein the lens body has a apex, and the continuous aspheric surface extends from the apex for a radius of at least 1.0 mm.
33. The implant of claim 21, wherein the optically, clear bio-compatible material is a permeable, microporous hydrogel.
34. The implant of claim 33, wherein then microporous hydrogel has a water content greater than 40% and up to approximately 90%
35. The implant of claim 21, wherein the aspheric surface is defined by the formula: ha + (1+Q)Z2 - 2ZR = 0, wherein the Z axis is the optical axis, wherein h2 = X2 + Y2, wherein R is the vertex radius of curvature, and wherein Q is the surface asphericity and Q < 0.
36. A corneal implant, comprising:
a lens body formed of an optically clear microporous hydrogel, the lens body having an anterior surface and a posterior surface, and an outer diameter edge, the outer diameter edge having a thickness less than about .015 mm, the lens body having a diameter between about 2.0 mm and 7.0mm;
the bio-compatible material having a refractive index ranging from 1.36-1.39;
and the anterior surface being convex in shape with a continuous aspheric surface;
wherein the lens body has a beveled surface connecting the outer diameter edge and the aspheric surface.
a lens body formed of an optically clear microporous hydrogel, the lens body having an anterior surface and a posterior surface, and an outer diameter edge, the outer diameter edge having a thickness less than about .015 mm, the lens body having a diameter between about 2.0 mm and 7.0mm;
the bio-compatible material having a refractive index ranging from 1.36-1.39;
and the anterior surface being convex in shape with a continuous aspheric surface;
wherein the lens body has a beveled surface connecting the outer diameter edge and the aspheric surface.
37. The implant of claim 36, wherein the lens body is circular in shape.
38. The implant of claim 36, wherein the outer diameter edge has a substantially planar surface.
39. The implant of claim 36, wherein the aspheric surface is adapted for the correction of presbyopia.
40. The implant of claim 36, wherein the aspheric surface is adapted for the correction of hyperopia.
41. The implant of claim 36, wherein the aspheric surface is adapted for the correction of myopia.
42. The implant of claim 36, wherein the lens body has an apex, and the continuous aspheric surface extends from the apex to the beveled surface.
43. The implant of claim 36, wherein the lens body is circular in shape.
44. The implant of claim 36, wherein the lens body has an apex, and the continuous aspheric surface extends from the apex for a radius of at least 1.0 mm.
45. The implant of claim. 36, wherein then microporous hydrogel has a water content greater than 40% and up to approximately 90%.
46. The implant of claim 36, wherein the aspheric surface is defined by the formula: h2 + (1+Q)Z2 - 2ZR = 0, wherein the Z axis is the optical axis, wherein ha = X2 + Y2, wherein R is the vertex radius of curvature, and wherein Q is the surface asphericity and Q < 0.
47. A method of implanting a corneal implant, said method comprising the steps of:
(a) cutting away a portion of the outer surface of a cornea;
(b) implanting a lens on the exposed surface of the cornea, said lens having a lens body formed of an optically clear, bio-compatible material, the lens body having an anterior surface and a posterior surface, and an outer diameter edge, the bio-compatible material having a refractive index ranging from 1.36-1.39, and the anterior surface being convex in shape with a continuous aspheric surface; and (c) replacing the portion of the cornea that was cut away.
(a) cutting away a portion of the outer surface of a cornea;
(b) implanting a lens on the exposed surface of the cornea, said lens having a lens body formed of an optically clear, bio-compatible material, the lens body having an anterior surface and a posterior surface, and an outer diameter edge, the bio-compatible material having a refractive index ranging from 1.36-1.39, and the anterior surface being convex in shape with a continuous aspheric surface; and (c) replacing the portion of the cornea that was cut away.
48. The method of claim 47, wherein the posterior surface is concave in shape.
49. The method of claim 48, wherein the posterior surface is curved in shape with a posterior radii of curvature.
50. The method of claim 47, wherein the lens body has a thickness less than about .150 mm.
51. The method of claim 47, wherein the lens body has a diameter between about 2.0 mm and about 7.0 mm.
52. The method of claim 47, wherein the outer diameter edge has a thickness less than about.015 mm.
53. The method of claim 47, wherein the outer diameter edge has a substantially planar surface.
54. The method of claim 47, wherein the aspheric surface is adapted for the correction of presbyopia.
55. The method of claim 47, wherein the aspheric surface is adapted for the correction of hyperopia.
56. The method of claim 47, wherein the aspheric surface is adapted for the correction of myopia.
57. The method of claim 47, wherein the lens body has a beveled surface connecting the outer diameter edge and the aspheric surface.
58. The method of claim 57, wherein the lens body has an apex, and the continuous aspheric surface extends from the apex for a radius of at least 1.0 mm.
59. The method of claim 47, wherein the lens body has an apex, and the continuous aspheric surface extends from the apex to the beveled surface.
60. The method of claim 47, wherein the lens body is circular in shape.
61. The method of claim 47, wherein the optically clear, bio-compatible material is a permeable, microporous hydrogel.
62. The method of claim 47, wherein then microporous hydrogel has a water content greater than 40% and up to approximately 90%.
63. The method of claim 47, wherein the aspheric surface is defined by the formula:
h2+(1+Q)Za-2ZR=0, wherein the Z axis is the optical axis, wherein h2 = X2 + Y2, wherein R is the vertex radius of curvature, and wherein Q is the surface asphericity and Q < 0.
h2+(1+Q)Za-2ZR=0, wherein the Z axis is the optical axis, wherein h2 = X2 + Y2, wherein R is the vertex radius of curvature, and wherein Q is the surface asphericity and Q < 0.
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US10/837,402 US7776086B2 (en) | 2004-04-30 | 2004-04-30 | Aspherical corneal implant |
PCT/US2005/014653 WO2005107648A2 (en) | 2004-04-30 | 2005-04-28 | Aspherical corneal implant |
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CA2563340C CA2563340C (en) | 2013-07-16 |
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---|---|
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Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3143218B2 (en) * | 1992-07-28 | 2001-03-07 | 株式会社クボタ | Seedling stuffing equipment |
WO2000052516A2 (en) | 1999-03-01 | 2000-09-08 | Boston Innovative Optics, Inc. | System and method for increasing the depth of focus of the human eye |
AU2001289038B2 (en) | 2000-09-12 | 2006-05-18 | Revision Optics, Inc. | System for packaging and handling an implant and method of use |
US8668735B2 (en) | 2000-09-12 | 2014-03-11 | Revision Optics, Inc. | Corneal implant storage and delivery devices |
US10835371B2 (en) * | 2004-04-30 | 2020-11-17 | Rvo 2.0, Inc. | Small diameter corneal inlay methods |
US20110218623A1 (en) * | 2004-04-30 | 2011-09-08 | Jon Dishler | Small Diameter Inlays |
US8057541B2 (en) * | 2006-02-24 | 2011-11-15 | Revision Optics, Inc. | Method of using small diameter intracorneal inlays to treat visual impairment |
US10555805B2 (en) * | 2006-02-24 | 2020-02-11 | Rvo 2.0, Inc. | Anterior corneal shapes and methods of providing the shapes |
AU2012201316B2 (en) * | 2006-02-24 | 2012-09-06 | Revision Optics, Inc. | Small diameter inlays |
US8394140B2 (en) * | 2006-03-17 | 2013-03-12 | Addition Technology, Inc. | Pre-formed intrastromal corneal insert for corneal abnormalities or dystrophies |
US9271828B2 (en) | 2007-03-28 | 2016-03-01 | Revision Optics, Inc. | Corneal implant retaining devices and methods of use |
US9549848B2 (en) | 2007-03-28 | 2017-01-24 | Revision Optics, Inc. | Corneal implant inserters and methods of use |
US8162953B2 (en) | 2007-03-28 | 2012-04-24 | Revision Optics, Inc. | Insertion system for corneal implants |
ES2739386T3 (en) | 2007-10-29 | 2020-01-30 | Junzhong Liang | Devices for refractive treatments of presbyopia |
MX345877B (en) | 2008-04-02 | 2017-02-21 | Liang Junzhong | Methods and devices for refractive corrections of presbyopia. |
JP2011516180A (en) | 2008-04-04 | 2011-05-26 | レヴィジオン・オプティックス・インコーポレーテッド | Corneal inlay design and method for correcting vision |
US9539143B2 (en) * | 2008-04-04 | 2017-01-10 | Revision Optics, Inc. | Methods of correcting vision |
US8469948B2 (en) | 2010-08-23 | 2013-06-25 | Revision Optics, Inc. | Methods and devices for forming corneal channels |
DE102011106289A1 (en) | 2011-07-01 | 2013-01-03 | Carl Zeiss Meditec Ag | Corneal implant |
NL2007285C2 (en) * | 2011-08-19 | 2013-02-21 | Oculentis B V | Intraocular lens. |
US9345569B2 (en) | 2011-10-21 | 2016-05-24 | Revision Optics, Inc. | Corneal implant storage and delivery devices |
US9545303B2 (en) | 2011-12-02 | 2017-01-17 | Acufocus, Inc. | Ocular mask having selective spectral transmission |
TWI588560B (en) | 2012-04-05 | 2017-06-21 | 布萊恩荷登視覺協會 | Lenses, devices, methods and systems for refractive error |
EP2664300B1 (en) * | 2012-05-14 | 2020-10-28 | Presbia Ireland Limited | Intracorneal lens |
US9201250B2 (en) | 2012-10-17 | 2015-12-01 | Brien Holden Vision Institute | Lenses, devices, methods and systems for refractive error |
EP2908773B1 (en) | 2012-10-17 | 2024-01-03 | Brien Holden Vision Institute | Lenses, devices, methods and systems for refractive error |
US9204962B2 (en) | 2013-03-13 | 2015-12-08 | Acufocus, Inc. | In situ adjustable optical mask |
US10092393B2 (en) | 2013-03-14 | 2018-10-09 | Allotex, Inc. | Corneal implant systems and methods |
US9427922B2 (en) | 2013-03-14 | 2016-08-30 | Acufocus, Inc. | Process for manufacturing an intraocular lens with an embedded mask |
WO2016144404A1 (en) | 2015-03-12 | 2016-09-15 | Revision Optics, Inc. | Methods of correcting vision |
US10449090B2 (en) | 2015-07-31 | 2019-10-22 | Allotex, Inc. | Corneal implant systems and methods |
AU2017283194A1 (en) | 2016-06-23 | 2019-01-17 | Medicem Institute s.r.o. | Light-adjustable hydrogel and bioanalogic intraocular lens |
US11737919B2 (en) * | 2021-06-17 | 2023-08-29 | EyeYon Medical Ltd. | Endothelial ocular implant |
Family Cites Families (260)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3168100A (en) * | 1962-12-07 | 1965-02-02 | Alvido R Rich | Contact lens dipper assembly |
US3482906A (en) | 1965-10-04 | 1969-12-09 | David Volk | Aspheric corneal contact lens series |
US3379200A (en) * | 1965-10-24 | 1968-04-23 | Ruth M. Pennell | Lens containtr |
US3343657A (en) | 1966-09-02 | 1967-09-26 | Reuben F Speshyock | Contact lens conditioning facility |
US3950315A (en) * | 1971-06-11 | 1976-04-13 | E. I. Du Pont De Nemours And Company | Contact lens having an optimum combination of properties |
US3743337A (en) | 1971-07-26 | 1973-07-03 | E Crary | Contact lens inserter |
US3770113A (en) | 1972-03-03 | 1973-11-06 | Mcd Corp | Contact lens holder |
US3879076A (en) * | 1973-12-27 | 1975-04-22 | Robert O Barnett | Method and apparatus for applying and removing a soft contact lens |
US4037604A (en) | 1976-01-05 | 1977-07-26 | Newkirk John B | Artifical biological drainage device |
US4030480A (en) | 1976-05-13 | 1977-06-21 | Ernst Jochen Meyer | Ocular decompression process |
US4039827A (en) | 1976-08-26 | 1977-08-02 | American Optical Corporation | Method for marking intraocular lenses |
US4071272A (en) * | 1976-09-27 | 1978-01-31 | Drdlik Frank J | Contact lens applicator |
US4157718A (en) | 1977-08-31 | 1979-06-12 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Intra-ocular pressure normalization technique and equipment |
US4184491A (en) * | 1977-08-31 | 1980-01-22 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Intra-ocular pressure normalization technique and equipment |
US4194814A (en) * | 1977-11-10 | 1980-03-25 | Bausch & Lomb Incorporated | Transparent opthalmic lens having engraved surface indicia |
US4238524A (en) | 1978-03-06 | 1980-12-09 | American Optical Corporation | Process for identification marking clear plastic articles |
US4268133A (en) * | 1978-07-14 | 1981-05-19 | Bausch & Lomb Incorporated | Preferential orientation of contact lenses |
US4392569A (en) | 1979-06-06 | 1983-07-12 | Shoup Leo E | Soft contact lens asepticizing case |
US4418991A (en) | 1979-09-24 | 1983-12-06 | Breger Joseph L | Presbyopic contact lens |
US4257521A (en) * | 1979-11-16 | 1981-03-24 | Stanley Poler | Packaging means for an intraocular lens |
US4326306A (en) * | 1980-12-16 | 1982-04-27 | Lynell Medical Technology, Inc. | Intraocular lens and manipulating tool therefor |
US4428746A (en) * | 1981-07-29 | 1984-01-31 | Antonio Mendez | Glaucoma treatment device |
US5188125A (en) * | 1982-01-04 | 1993-02-23 | Keravision, Inc. | Method for corneal curvature adjustment |
US4671276A (en) | 1982-01-04 | 1987-06-09 | Kera Associates | Apparatus for corneal curvature adjustment |
US4766895A (en) | 1982-01-04 | 1988-08-30 | Kera Corneal Devices, Inc. | Apparatus for corneal curvature adjustment |
US4452235A (en) | 1982-01-04 | 1984-06-05 | Reynolds Alvin E | Method for corneal curvature adjustment |
US4490860A (en) * | 1982-01-18 | 1985-01-01 | Ioptex Inc. | Intraocular lens apparatus and method for implantation of same |
US4702244A (en) | 1982-02-05 | 1987-10-27 | Staar Surgical Company | Surgical device for implantation of a deformable intraocular lens |
US4423809A (en) * | 1982-02-05 | 1984-01-03 | Staar Surgical Company, Inc. | Packaging system for intraocular lens structures |
DE3208729A1 (en) | 1982-03-11 | 1983-09-22 | Jörg Dr.med. 4630 Bochum Krumeich | Plastic lens |
US4545478A (en) | 1982-07-08 | 1985-10-08 | Fred Waldman | Hard contact lens suction cups and method for their production |
US4554918A (en) | 1982-07-28 | 1985-11-26 | White Thomas C | Ocular pressure relief device |
US4504982A (en) * | 1982-08-05 | 1985-03-19 | Optical Radiation Corporation | Aspheric intraocular lens |
US4619256A (en) | 1982-09-08 | 1986-10-28 | Gerald Horn | Intraocular lens inserting assembly |
US4466705A (en) | 1982-09-30 | 1984-08-21 | Michelson Paul E | Fluid lens |
US4521210A (en) | 1982-12-27 | 1985-06-04 | Wong Vernon G | Eye implant for relieving glaucoma, and device and method for use therewith |
US4616910A (en) | 1983-03-01 | 1986-10-14 | Klein Robert E | Visual indicator on soft contact lenses |
US4580882A (en) * | 1983-04-21 | 1986-04-08 | Benjamin Nuchman | Continuously variable contact lens |
US4525044A (en) | 1983-05-05 | 1985-06-25 | Bauman Robert C | Soft contact lens with surface identification and method of using same |
US4554115A (en) | 1983-08-30 | 1985-11-19 | Neefe Charles W | Method of controlling the convex curve of soft lenses |
US4618227A (en) | 1983-10-07 | 1986-10-21 | Vistakon, Inc. | Soft contact lens |
US4565198A (en) * | 1983-12-27 | 1986-01-21 | Barnes-Hind, Inc. | Method for altering the curvature of the cornea |
US4586929A (en) * | 1984-04-06 | 1986-05-06 | Binder Perry S | Hydrogel keratoprosthesis |
US4640595A (en) * | 1984-05-02 | 1987-02-03 | David Volk | Aspheric contact lens |
US4971732A (en) | 1984-06-28 | 1990-11-20 | Ceskoslovenska Academie Ved | Method of molding an intraocular lens |
DE3433581C2 (en) * | 1984-09-13 | 1986-08-07 | Fa. Carl Zeiss, 7920 Heidenheim | Device for laminating, refractive corneal surgery |
US4624669A (en) | 1984-09-26 | 1986-11-25 | Surgidev Corporation | Corneal inlay with holes |
US4604087A (en) | 1985-02-26 | 1986-08-05 | Joseph Neil H | Aqueous humor drainage device |
US4646720A (en) * | 1985-03-12 | 1987-03-03 | Peyman Gholam A | Optical assembly permanently attached to the cornea |
JPH0678460B2 (en) * | 1985-05-01 | 1994-10-05 | 株式会社バイオマテリアル・ユニバース | Porous transparent polyvinyl alcohol gel |
US6264648B1 (en) | 1985-07-29 | 2001-07-24 | Bausch & Lomb Incorporated | Corneal curvature modification via internal ablation |
GB2185124B (en) * | 1986-01-03 | 1989-10-25 | Choyce David P | Intra-corneal implant |
NZ215409A (en) | 1986-03-07 | 1989-02-24 | Anthony Christopher Be Molteno | Implant for drainage of aqueous humour in glaucoma |
US5139518A (en) | 1986-05-16 | 1992-08-18 | White Thomas C | Methods employed in replacement of the corneal endothelium |
CS263203B1 (en) * | 1986-07-22 | 1989-04-14 | Sulc Jiri | Soft intraocular lenses |
US5019084A (en) * | 1986-08-06 | 1991-05-28 | Minnesota Mining And Manufacturing Company | Corneal holder |
US4697697A (en) | 1986-08-18 | 1987-10-06 | Coopervision, Inc. | Method and apparatus for packaging an intraocular lens |
US4676792A (en) | 1986-08-26 | 1987-06-30 | Donald Praeger | Method and artificial intraocular lens device for the phakic treatment of myopia |
US5112350A (en) * | 1986-10-16 | 1992-05-12 | Cbs Lens, A California General Partnership | Method for locating on a cornea an artificial lens fabricated from a collagen-hydrogel for promoting epithelial cell growth and regeneration of the stroma |
US5114627A (en) * | 1986-10-16 | 1992-05-19 | Cbs Lens | Method for producing a collagen hydrogel |
US4842599A (en) * | 1986-10-28 | 1989-06-27 | Ann M. Bronstein | Prosthetic cornea and method of implantation therefor |
US4919130A (en) * | 1986-11-07 | 1990-04-24 | Nestle S.A. | Tool for inserting compressible intraocular lenses into the eye and method |
US4897981A (en) * | 1986-12-24 | 1990-02-06 | Alcon Laboratories, Inc. | Method of packaging intraocular lenses and contact lenses |
US4840175A (en) | 1986-12-24 | 1989-06-20 | Peyman Gholam A | Method for modifying corneal curvature |
US4762496A (en) | 1987-02-13 | 1988-08-09 | William F. Maloney | Ophthalmologic lens phantom system |
US4806382A (en) * | 1987-04-10 | 1989-02-21 | University Of Florida | Ocular implants and methods for their manufacture |
US5244799A (en) | 1987-05-20 | 1993-09-14 | Anderson David M | Preparation of a polymeric hydrogel containing micropores and macropores for use as a cell culture substrate |
US5270744A (en) | 1987-06-01 | 1993-12-14 | Valdemar Portney | Multifocal ophthalmic lens |
US5225858A (en) | 1987-06-01 | 1993-07-06 | Valdemar Portney | Multifocal ophthalmic lens |
US4886488A (en) | 1987-08-06 | 1989-12-12 | White Thomas C | Glaucoma drainage the lacrimal system and method |
US4844242A (en) | 1987-09-02 | 1989-07-04 | The Johns Hopkins University | Cornea retainer |
EP0308077A3 (en) | 1987-09-14 | 1990-05-30 | Nestle S.A. | Synthetic intracorneal lens |
US4934363A (en) | 1987-12-15 | 1990-06-19 | Iolab Corporation | Lens insertion instrument |
US4851003A (en) | 1988-01-05 | 1989-07-25 | Lindstrom Richard L | Corneal implant lens with fixation holes |
US4888016A (en) | 1988-02-10 | 1989-12-19 | Langerman David W | "Spare parts" for use in ophthalmic surgical procedures |
US5108428A (en) * | 1988-03-02 | 1992-04-28 | Minnesota Mining And Manufacturing Company | Corneal implants and manufacture and use thereof |
US4836201A (en) | 1988-03-24 | 1989-06-06 | Patton Medical Technologies, Inc. | "Envelope" apparatus for inserting intra-ocular lens into the eye |
US4936825A (en) | 1988-04-11 | 1990-06-26 | Ungerleider Bruce A | Method for reducing intraocular pressure caused by glaucoma |
US4860885A (en) | 1988-04-29 | 1989-08-29 | Allergan, Inc. | Lens storage system |
US5273750A (en) | 1988-05-02 | 1993-12-28 | Institute National De La Sante Et De La Recherche Medicale- Inserm | Uncrosslinked hydrogel, process for its preparation and its uses as an article for medical and/or surgical purposes such as tubes, films, joints, implants and the like, particularly in ophthalmology |
US5211660A (en) * | 1988-05-02 | 1993-05-18 | University Of South Florida | Method for performing epikeratophakia by electrofusion |
US5192317A (en) * | 1988-07-26 | 1993-03-09 | Irvin Kalb | Multi focal intra-ocular lens |
US5785674A (en) | 1988-10-07 | 1998-07-28 | Mateen; Ahmed Abdul | Device and method for treating glaucoma |
US4976719A (en) | 1988-11-21 | 1990-12-11 | Siepser Steven B | Device used to change corneal curvature |
FR2647227B1 (en) * | 1989-05-19 | 1991-08-23 | Essilor Int | OPTICAL COMPONENT, SUCH AS AN INTRAOCULAR IMPLANT OR CONTACT LENS, SUITABLE FOR CORRECTING THE VISION OF AN INDIVIDUAL |
EP0420549A3 (en) | 1989-09-25 | 1991-06-12 | Kingston Technologies, Inc. | Corneal lens implant |
US4946436A (en) | 1989-11-17 | 1990-08-07 | Smith Stewart G | Pressure-relieving device and process for implanting |
US5063942A (en) | 1989-12-14 | 1991-11-12 | Corneal Contouring, Inc. | Method for surgically re-profiling the cornea |
US5318044A (en) | 1989-12-14 | 1994-06-07 | Corneal Contouring, Inc. | Method and apparatus for re-profiling the cornea to correct for hyperopia |
US5591185A (en) * | 1989-12-14 | 1997-01-07 | Corneal Contouring Development L.L.C. | Method and apparatus for reprofiling or smoothing the anterior or stromal cornea by scraping |
US4968296A (en) | 1989-12-20 | 1990-11-06 | Robert Ritch | Transscleral drainage implant device for the treatment of glaucoma |
US5092837A (en) * | 1989-12-20 | 1992-03-03 | Robert Ritch | Method for the treatment of glaucoma |
US5073163A (en) | 1990-01-29 | 1991-12-17 | Lippman Myron E | Apparatus for treating glaucoma |
US5098444A (en) * | 1990-03-16 | 1992-03-24 | Feaster Fred T | Epiphakic intraocular lens and process of implantation |
US5180362A (en) * | 1990-04-03 | 1993-01-19 | Worst J G F | Gonio seton |
US5181053A (en) * | 1990-05-10 | 1993-01-19 | Contact Lens Corporation Of America | Multi-focal contact lens |
US5041081A (en) | 1990-05-18 | 1991-08-20 | Odrich Ronald B | Ocular implant for controlling glaucoma |
US5397300A (en) * | 1990-05-31 | 1995-03-14 | Iovision, Inc. | Glaucoma implant |
US5178604A (en) * | 1990-05-31 | 1993-01-12 | Iovision, Inc. | Glaucoma implant |
US5476445A (en) | 1990-05-31 | 1995-12-19 | Iovision, Inc. | Glaucoma implant with a temporary flow restricting seal |
US5634943A (en) | 1990-07-12 | 1997-06-03 | University Of Miami | Injectable polyethylene oxide gel implant and method for production |
US5229797A (en) | 1990-08-08 | 1993-07-20 | Minnesota Mining And Manufacturing Company | Multifocal diffractive ophthalmic lenses |
US5173723A (en) | 1990-10-02 | 1992-12-22 | Volk Donald A | Aspheric ophthalmic accommodating lens design for intraocular lens and contact lens |
WO1992007525A1 (en) | 1990-10-31 | 1992-05-14 | Baxter International Inc. | Close vascularization implant material |
US5071276A (en) | 1991-01-04 | 1991-12-10 | Abbott Laboratories | Contact lens cleaning system |
WO1992013501A1 (en) * | 1991-02-11 | 1992-08-20 | Ommaya Ayub K | Spinal fluid driven artificial organ |
US5454796A (en) | 1991-04-09 | 1995-10-03 | Hood Laboratories | Device and method for controlling intraocular fluid pressure |
US5300020A (en) * | 1991-05-31 | 1994-04-05 | Medflex Corporation | Surgically implantable device for glaucoma relief |
US5123905A (en) | 1991-06-07 | 1992-06-23 | Kelman Charles D | Intraocular lens injector |
US5512220A (en) * | 1991-07-10 | 1996-04-30 | Johnson & Johnson Vision Products, Inc. | Method of making a clear axis, segmented multifocal ophthalmic lens |
US5171213A (en) | 1991-08-14 | 1992-12-15 | Price Jr Francis W | Technique for fistulization of the eye and an eye filtration prosthesis useful therefor |
US5428412B1 (en) | 1991-08-23 | 2000-08-08 | Contex Inc | Method for treating myopia with an aspheric corneal contact lens |
US5196026A (en) * | 1991-09-16 | 1993-03-23 | Chiron Ophthalmics, Inc. | Method of implanting corneal inlay lenses smaller than the optic zone |
US5258042A (en) | 1991-12-16 | 1993-11-02 | Henry Ford Health System | Intravascular hydrogel implant |
WO1993012735A1 (en) * | 1992-01-02 | 1993-07-08 | Chiron Intraoptics, Inc. | Corneal ring inlay and methods of use |
SG85138A1 (en) | 1992-01-14 | 2001-12-19 | Keravision Inc | Split ring refractive correction implants |
US5190552A (en) * | 1992-02-04 | 1993-03-02 | Kelman Charles D | Slotted tube injector for an intraocular lens |
US5346464A (en) | 1992-03-10 | 1994-09-13 | Camras Carl B | Method and apparatus for reducing intraocular pressure |
AU650156B2 (en) * | 1992-08-05 | 1994-06-09 | Lions Eye Institute Limited | Keratoprosthesis and method of producing the same |
DK0653926T3 (en) * | 1992-08-07 | 1999-11-01 | Keravision Inc | Intrastromal corneal ring |
US5405384A (en) * | 1992-09-03 | 1995-04-11 | Keravision, Inc. | Astigmatic correcting intrastromal corneal ring |
US5944752A (en) | 1992-09-03 | 1999-08-31 | Kera Vision, Inc. | Astigmatic correcting intrastromal corneal insert |
US5620450A (en) * | 1992-09-30 | 1997-04-15 | Staar Surgical Company, Inc. | Transverse hinged deformable intraocular lens injecting apparatus |
US5616148A (en) * | 1992-09-30 | 1997-04-01 | Staar Surgical Company, Inc. | Transverse hinged deformable intraocular lens injecting apparatus |
US6712848B1 (en) * | 1992-09-30 | 2004-03-30 | Staar Surgical Company, Inc. | Deformable intraocular lens injecting apparatus with transverse hinged lens cartridge |
US6022358A (en) | 1992-09-30 | 2000-02-08 | Staar Surgical Company, Inc. | Deformable intraocular lens injecting device |
US6056757A (en) | 1992-09-30 | 2000-05-02 | Staar Surgical Company, Inc. | Implantation device with deformable nozzle tip for implanting a deformable intraocular lens |
US5860984A (en) * | 1992-09-30 | 1999-01-19 | Staar Surgical Company, Inc. | Spring biased deformable intraocular injecting apparatus |
US5928245A (en) | 1992-09-30 | 1999-07-27 | Staar Surgical Company, Inc. | Deformable intraocular lens injecting apparatus with transverse hinged lens cartridge |
US5370607A (en) | 1992-10-28 | 1994-12-06 | Annuit Coeptis, Inc. | Glaucoma implant device and method for implanting same |
US5406341A (en) * | 1992-11-23 | 1995-04-11 | Innotech, Inc. | Toric single vision, spherical or aspheric bifocal, multifocal or progressive contact lenses and method of manufacturing |
US5872613A (en) * | 1992-11-23 | 1999-02-16 | Innotech, Inc. | Method of manufacturing contact lenses |
US5338291A (en) | 1993-02-03 | 1994-08-16 | Pudenz-Schulte Medical Research Corporation | Glaucoma shunt and method for draining aqueous humor |
FR2701770B1 (en) | 1993-02-18 | 1995-05-12 | Essilor Int | Simultaneous vision ophthalmic lens for the correction of presbyopia and set of two such ophthalmic lenses for the same wearer. |
US6090141A (en) | 1993-03-05 | 2000-07-18 | Lindstrom; Richard L. | Small intracorneal lens |
US5653715A (en) | 1993-03-09 | 1997-08-05 | Chiron Vision Corporation | Apparatus for preparing an intraocular lens for insertion |
US5493350A (en) * | 1993-03-31 | 1996-02-20 | Seidner; Leonard | Multipocal contact lens and method for preparing |
US5467149A (en) | 1993-06-15 | 1995-11-14 | Bausch & Lomb Incorporated | Highly visible markings for contact lenses |
US5468246A (en) | 1993-07-02 | 1995-11-21 | Iovision, Inc. | Intraocular lens injector |
CA2168347A1 (en) | 1993-08-02 | 1995-02-09 | Thomas A. Silvestrini | Segmented preformed intrastromal corneal insert |
US5502518A (en) * | 1993-09-09 | 1996-03-26 | Scient Optics Inc | Asymmetric aspheric contact lens |
WO1995013766A1 (en) | 1993-11-18 | 1995-05-26 | Allergan, Inc. | Deformable lens insertion apparatus |
US6197019B1 (en) * | 1994-04-25 | 2001-03-06 | Gholam A. Peyman | Universal implant blank for modifying corneal curvature and methods of modifying corneal curvature therewith |
US5630810A (en) | 1994-05-06 | 1997-05-20 | Machat; Jeffery J. | Method of ophthalmological surgery |
US5629577A (en) | 1994-07-15 | 1997-05-13 | Micro Medical Devices | Miniature linear motion actuator |
US5520631A (en) * | 1994-07-22 | 1996-05-28 | Wound Healing Of Oklahoma | Method and apparatus for lowering the intraocular pressure of an eye |
EP0785759B1 (en) | 1994-10-06 | 2004-03-31 | FEINGOLD, Vladimir | Intraocular contact lens |
US5433701A (en) | 1994-12-21 | 1995-07-18 | Rubinstein; Mark H. | Apparatus for reducing ocular pressure |
IL117335A (en) | 1995-03-02 | 2001-08-08 | Keravision Inc | Corneal implant for changing refractive properties |
US6110166A (en) | 1995-03-20 | 2000-08-29 | Escalon Medical Corporation | Method for corneal laser surgery |
TW393498B (en) | 1995-04-04 | 2000-06-11 | Novartis Ag | The preparation and use of Polysiloxane-comprising perfluoroalkyl ethers |
US5929969A (en) | 1995-05-04 | 1999-07-27 | Johnson & Johnson Vision Products, Inc. | Multifocal ophthalmic lens |
IL117937A0 (en) | 1995-05-04 | 1996-08-04 | Johnson & Johnson Vision Prod | Combined multifocal toric lens designs |
IL118064A0 (en) | 1995-05-04 | 1996-08-04 | Johnson & Johnson Vision Prod | Concentric annular ring lens designs for astigmatic presbyopes |
US5715031A (en) * | 1995-05-04 | 1998-02-03 | Johnson & Johnson Vision Products, Inc. | Concentric aspheric multifocal lens designs |
US5684560A (en) | 1995-05-04 | 1997-11-04 | Johnson & Johnson Vision Products, Inc. | Concentric ring single vision lens designs |
US5643276A (en) | 1995-10-10 | 1997-07-01 | Allergan | Apparatus and method for providing desired rotational orientation to an intraocular lens |
US6551307B2 (en) * | 2001-03-23 | 2003-04-22 | Gholam A. Peyman | Vision correction using intrastromal pocket and flap |
US6280470B1 (en) | 1995-10-20 | 2001-08-28 | Gholam A. Peyman | Intrastromal corneal modification |
US5722971A (en) * | 1995-10-20 | 1998-03-03 | Peyman; Gholam A. | Intrastromal corneal modification |
US5964748A (en) * | 1995-10-20 | 1999-10-12 | Peyman; Gholam A. | Intrastromal corneal modification |
US20050143717A1 (en) | 2001-04-27 | 2005-06-30 | Peyman Gholam A. | Method of treatment of refractive errors using subepithelial or intrastromal corneal inlay with bonding coating |
US5919185A (en) | 1997-04-25 | 1999-07-06 | Peyman; Gholam A. | Universal implant blank for modifying corneal curvature and methods of modifying corneal curvature therewith |
US6221067B1 (en) * | 1995-10-20 | 2001-04-24 | Gholam A. Peyman | Corneal modification via implantation |
US5929968A (en) | 1995-11-01 | 1999-07-27 | Cotie; Robert L. | Scleral-corneal contact lens |
US6203538B1 (en) * | 1995-11-03 | 2001-03-20 | Gholam A. Peyman | Intrastromal corneal modification |
US5817115A (en) | 1995-12-04 | 1998-10-06 | Chiron Vision Corporation | Apparatus for resecting corneal tissue |
US5722948A (en) * | 1996-02-14 | 1998-03-03 | Gross; Fredric J. | Covering for an ocular device |
US5628794A (en) | 1996-03-08 | 1997-05-13 | Lindstrom; Richard L. | Multifocal corneal implant lens having a hydrogelo coating |
US5766181A (en) | 1996-08-02 | 1998-06-16 | Staar Surgical Company, Inc. | Spring biased deformable intraocular injecting apparatus |
AUPO185796A0 (en) | 1996-08-26 | 1996-09-19 | Lions Eye Institute | Ocular socket prosthesis |
US6142969A (en) | 1996-10-25 | 2000-11-07 | Anamed, Inc. | Sutureless implantable device and method for treatment of glaucoma |
US6881197B1 (en) * | 1996-10-25 | 2005-04-19 | Anamed, Inc. | Sutureless implantable device and method for treatment of glaucoma |
US6007510A (en) | 1996-10-25 | 1999-12-28 | Anamed, Inc. | Implantable devices and methods for controlling the flow of fluids within the body |
US5876439A (en) * | 1996-12-09 | 1999-03-02 | Micooptix, Llc | Method and appartus for adjusting corneal curvature using a fluid-filled corneal ring |
US5733334A (en) | 1996-12-09 | 1998-03-31 | Microoptix | Method and apparatus for adjusting corneal curvature |
US5855604A (en) * | 1996-12-09 | 1999-01-05 | Microoptix, Llc | Method and apparatus for adjusting corneal curvature using a solid filled corneal ring |
US6159241A (en) | 1997-04-01 | 2000-12-12 | Joseph Y. Lee | Method and apparatus for adjusting corneal curvature using multiple removable corneal implants |
US6228114B1 (en) | 1997-04-01 | 2001-05-08 | Joseph Y. Lee | Adjustable corneal ring |
ID20540A (en) | 1997-04-07 | 1999-01-07 | Bausch & Lomb | METHOD FOR UNTUYK IDENTIFY THE CHARACTERISTICS OF THE CONTACT LENS |
US6055990A (en) | 1997-04-21 | 2000-05-02 | Thompson; Keith P. | Polymerizing gel intrakeratophakia-PGI |
US5752928A (en) | 1997-07-14 | 1998-05-19 | Rdo Medical, Inc. | Glaucoma pressure regulator |
US5964776A (en) | 1997-09-24 | 1999-10-12 | Peyman; Gholam A. | Internal keratome apparatus and method for using the same to form a pocket/flap between layers of a live cornea |
US5941583A (en) | 1997-10-07 | 1999-08-24 | Raimondi; Kent | Contact lens insertion and manipulation assembly and method |
US6007578A (en) | 1997-10-08 | 1999-12-28 | Ras Holding Corp | Scleral prosthesis for treatment of presbyopia and other eye disorders |
US6605093B1 (en) | 1997-10-24 | 2003-08-12 | Tekia, Inc. | Device and method for use with an ophthalmologic insertor apparatus |
AU7361898A (en) | 1997-10-24 | 1999-05-17 | Tekia, Inc. | Ophthalmologic insertor apparatus and methods of use |
US6033395A (en) * | 1997-11-03 | 2000-03-07 | Peyman; Gholam A. | System and method for modifying a live cornea via laser ablation and mechanical erosion |
US20020055753A1 (en) | 1997-12-18 | 2002-05-09 | Thomas A. Silvestrini | Corneal implant methods and pliable implant therefor |
US6050999A (en) * | 1997-12-18 | 2000-04-18 | Keravision, Inc. | Corneal implant introducer and method of use |
US5936704A (en) * | 1997-12-22 | 1999-08-10 | Gabrielian; Grant | Marked contact lens bearing optical marking element |
WO1999033411A1 (en) * | 1997-12-29 | 1999-07-08 | Duckworth & Kent Limited | Injectors for intraocular lenses |
US6428572B2 (en) | 1998-01-12 | 2002-08-06 | Menicon Co., Ltd. | Intraocular ring |
US6206919B1 (en) * | 1998-01-14 | 2001-03-27 | Joseph Y. Lee | Method and apparatus to correct refractive errors using adjustable corneal arcuate segments |
US5921989A (en) | 1998-02-12 | 1999-07-13 | Allergan | Lens protector for intraocular lens inserter |
US6024448A (en) * | 1998-03-31 | 2000-02-15 | Johnson & Johnson Vision Products, Inc. | Contact lenses bearing identifying marks |
FR2777093B1 (en) | 1998-04-07 | 2000-06-23 | Essilor Int | METHOD FOR PRODUCING ANGULAR TOLERANCE MARK FOR AN ASTIGMATIC CORRECTIVE LENS, AND ASSOCIATED LENS |
US6371960B2 (en) * | 1998-05-19 | 2002-04-16 | Bausch & Lomb Surgical, Inc. | Device for inserting a flexible intraocular lens |
US5947976A (en) | 1998-06-02 | 1999-09-07 | Alcon Laboratories, Inc. | Asymmetric intraocular lens injection cartridge |
US6143001A (en) | 1998-06-02 | 2000-11-07 | Alcon Laboratories, Inc. | Asymmetric intraocular lens injection cartridge |
US6010510A (en) * | 1998-06-02 | 2000-01-04 | Alcon Laboratories, Inc. | Plunger |
US6183513B1 (en) * | 1998-06-05 | 2001-02-06 | Bausch & Lomb Surgical, Inc. | Intraocular lens packaging system, method of producing, and method of using |
US5976150A (en) | 1998-08-25 | 1999-11-02 | Alcon Laboratories, Inc. | Intraocular lens injection system |
US6120148A (en) | 1998-10-05 | 2000-09-19 | Bifocon Optics Gmbh | Diffractive lens |
US6197057B1 (en) * | 1998-10-27 | 2001-03-06 | Gholam A. Peyman | Lens conversion system for teledioptic or difractive configurations |
US6447520B1 (en) | 2001-03-19 | 2002-09-10 | Advanced Medical Optics, Inc. | IOL insertion apparatus with IOL engagement structure and method for using same |
US6329485B1 (en) | 1998-12-11 | 2001-12-11 | Bausch & Lomb Incorporated | High refractive index hydrogel compositions for ophthalmic implants |
CA2351435A1 (en) * | 1998-12-16 | 2000-06-22 | William Rovani | Multifocal contact lens with aspheric surface |
US6102946A (en) * | 1998-12-23 | 2000-08-15 | Anamed, Inc. | Corneal implant and method of manufacture |
US6626941B2 (en) | 1998-12-23 | 2003-09-30 | Anamed, Inc. | Corneal implant and method of manufacture |
US6361560B1 (en) * | 1998-12-23 | 2002-03-26 | Anamed, Inc. | Corneal implant and method of manufacture |
DE19904220C2 (en) | 1999-02-03 | 2001-08-30 | Helmut Binder | Injector for folding and inserting an intraocular lens, and containers for storing and transporting the injector |
US6210005B1 (en) | 1999-02-04 | 2001-04-03 | Valdemar Portney | Multifocal ophthalmic lens with reduced halo size |
US6197058B1 (en) * | 1999-03-22 | 2001-03-06 | Valdemar Portney | Corrective intraocular lens system and intraocular lenses and lens handling device therefor |
US6129733A (en) | 1999-04-15 | 2000-10-10 | Allergan Sales, Inc. | Apparatus for holding intraocular lenses and injectors, and methods for using same |
US6511178B1 (en) * | 1999-07-19 | 2003-01-28 | Johnson & Johnson Vision Care, Inc. | Multifocal ophthalmic lenses and processes for their production |
US6248111B1 (en) | 1999-08-06 | 2001-06-19 | Allergan Sales, Inc. | IOL insertion apparatus and methods for using same |
US6325509B1 (en) * | 1999-08-20 | 2001-12-04 | Art Optical Contact Lens, Inc. | Low-mass ophthalmic lens |
US6271281B1 (en) | 1999-08-26 | 2001-08-07 | Medennium, Inc. | Homopolymers containing stable elasticity inducing crosslinkers and ocular implants made therefrom |
US6251114B1 (en) | 1999-10-29 | 2001-06-26 | Allergan Sales, Inc. | Rotatable IOL insertion apparatus and method for using same |
US6250757B1 (en) | 1999-12-15 | 2001-06-26 | Johnson & Johnson Vision Products, Inc. | Hybrid refractive birefringent multifocal ophthalmic lenses |
US6589203B1 (en) | 2000-01-26 | 2003-07-08 | Peter Mitrev | Glaucoma drainage device implant |
US6391230B1 (en) | 2000-02-18 | 2002-05-21 | Bausch & Lomb Incorporated | Intraocular lens manufacturing process |
US6283595B1 (en) | 2000-02-24 | 2001-09-04 | Joseph L. Breger | Pinhole presbyopic contact lenses |
US7048759B2 (en) * | 2000-02-24 | 2006-05-23 | Advanced Medical Optics, Inc. | Intraocular lenses |
US6458141B1 (en) | 2000-03-10 | 2002-10-01 | Gholam A. Peyman | Method and apparatus for creating a flap in the cornea and incisions or shrinkage under the flap to correct vision disorders |
US6436092B1 (en) | 2000-03-21 | 2002-08-20 | Gholam A. Peyman | Adjustable universal implant blank for modifying corneal curvature and methods of modifying corneal curvature therewith |
US6648877B1 (en) | 2000-06-30 | 2003-11-18 | Intralase Corp. | Method for custom corneal corrections |
US6544286B1 (en) * | 2000-07-18 | 2003-04-08 | Tissue Engineering Refraction, Inc. | Pre-fabricated corneal tissue lens method of corneal overlay to correct vision |
US7497866B2 (en) | 2000-07-18 | 2009-03-03 | Tissue Engineering Refraction Inc. | Methods for producing epithelial flaps on the cornea and for placement of ocular devices and lenses beneath an epithelial flap or membrane, epithelial delaminating devices, and structures of epithelium and ocular devices and lenses |
US6582076B1 (en) | 2000-08-30 | 2003-06-24 | Johnson & Johnson Vision Care, Inc. | Ophthalmic lenses useful in correcting astigmatism and presbyopia |
US6474814B1 (en) | 2000-09-08 | 2002-11-05 | Florida Optical Engineering, Inc | Multifocal ophthalmic lens with induced aperture |
AU2001289038B2 (en) | 2000-09-12 | 2006-05-18 | Revision Optics, Inc. | System for packaging and handling an implant and method of use |
US6543610B1 (en) | 2000-09-12 | 2003-04-08 | Alok Nigam | System for packaging and handling an implant and method of use |
US6554425B1 (en) * | 2000-10-17 | 2003-04-29 | Johnson & Johnson Vision Care, Inc. | Ophthalmic lenses for high order aberration correction and processes for production of the lenses |
US6398789B1 (en) | 2000-10-19 | 2002-06-04 | Alcon Universal, Ltd. | Intraocular lens injector cartridge |
US6666887B1 (en) | 2000-10-20 | 2003-12-23 | Thinoptx, Inc. | Deformable intraocular multi-focus lens |
US6471708B2 (en) | 2000-12-21 | 2002-10-29 | Bausch & Lomb Incorporated | Intraocular lens and additive packaging system |
JP2002303831A (en) * | 2001-01-30 | 2002-10-18 | Menicon Co Ltd | Contact lens |
US6398277B1 (en) | 2001-03-15 | 2002-06-04 | Mcdonald Marguerite B. | Contact lens insertion device |
US6589280B1 (en) | 2001-05-11 | 2003-07-08 | Jeffrey E. Koziol | Method for producing a multifocal corneal surface using intracorneal microscopic lenses |
US20030014042A1 (en) * | 2001-07-13 | 2003-01-16 | Tibor Juhasz | Method of creating stromal pockets for corneal implants |
US20030078487A1 (en) * | 2001-08-09 | 2003-04-24 | Jeffries Robert E. | Ocular pressure measuring device |
US6537283B2 (en) * | 2001-08-17 | 2003-03-25 | Alcon, Inc. | Intraocular lens shipping case and injection cartridge |
US6623522B2 (en) * | 2001-11-07 | 2003-09-23 | Alok Nigam | Myopic corneal ring with central accommodating portion |
US6786926B2 (en) | 2001-11-09 | 2004-09-07 | Minu, L.L.C. | Method and apparatus for alignment of intracorneal inlay |
DE60236532D1 (en) * | 2001-11-16 | 2010-07-08 | Zygo Corp | SCRATCH INTERFEROMETER FOR ASPHARIC SURFACES AND WAVE FRONTS |
US6723104B2 (en) * | 2002-03-13 | 2004-04-20 | Advanced Medical Optics, Inc. | IOL insertion apparatus and method for using same |
US6733507B2 (en) | 2002-04-12 | 2004-05-11 | Advanced Medical Optics, Inc. | Intraocular lens insertion apparatus |
US6733526B2 (en) | 2002-04-25 | 2004-05-11 | Advanced Medical Optics, Inc. | Method of improving adherence and centering of intra-corneal implants on corneal bed |
US20060189966A1 (en) | 2002-06-03 | 2006-08-24 | Scientific Optics, Inc. | Method and system for improving vision |
US6709103B1 (en) * | 2002-10-31 | 2004-03-23 | Johnson & Johnson Vision Care, Inc. | Methods for designing multifocal ophthalmic lenses |
AU2004268582A1 (en) | 2003-08-21 | 2005-03-10 | Revision Optics, Inc. | Method for keratophakia surgery |
US8057541B2 (en) | 2006-02-24 | 2011-11-15 | Revision Optics, Inc. | Method of using small diameter intracorneal inlays to treat visual impairment |
US20050246016A1 (en) | 2004-04-30 | 2005-11-03 | Intralens Vision, Inc. | Implantable lenses with modified edge regions |
US20060116762A1 (en) * | 2004-11-30 | 2006-06-01 | Xin Hong | Aspheric lenticule for keratophakia |
US20060235430A1 (en) | 2005-04-15 | 2006-10-19 | Intralens Vision, Inc. | Corneal implant injector assembly and methods of use |
US20070129797A1 (en) | 2005-12-01 | 2007-06-07 | Revision Optics, Inc. | Intracorneal inlays |
US20070255401A1 (en) | 2006-05-01 | 2007-11-01 | Revision Optics, Inc. | Design of Inlays With Intrinsic Diopter Power |
US20070280994A1 (en) | 2006-06-01 | 2007-12-06 | Cunanan Crystal M | Ocular Tissue Separation Areas With Barrier Regions For Inlays Or Other Refractive Procedures |
-
2004
- 2004-04-30 US US10/837,402 patent/US7776086B2/en active Active
-
2005
- 2005-04-28 CA CA2563340A patent/CA2563340C/en not_active Expired - Fee Related
- 2005-04-28 AU AU2005240037A patent/AU2005240037A1/en not_active Abandoned
- 2005-04-28 EP EP05745285A patent/EP1753371A2/en not_active Withdrawn
- 2005-04-28 WO PCT/US2005/014653 patent/WO2005107648A2/en active Application Filing
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US20050246015A1 (en) | 2005-11-03 |
CA2563340C (en) | 2013-07-16 |
AU2005240037A1 (en) | 2005-11-17 |
WO2005107648A2 (en) | 2005-11-17 |
EP1753371A2 (en) | 2007-02-21 |
US7776086B2 (en) | 2010-08-17 |
WO2005107648A3 (en) | 2006-02-16 |
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