CA2525911A1 - Skin dressings containing oxidoreductase enzyme - Google Patents

Skin dressings containing oxidoreductase enzyme Download PDF

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Publication number
CA2525911A1
CA2525911A1 CA002525911A CA2525911A CA2525911A1 CA 2525911 A1 CA2525911 A1 CA 2525911A1 CA 002525911 A CA002525911 A CA 002525911A CA 2525911 A CA2525911 A CA 2525911A CA 2525911 A1 CA2525911 A1 CA 2525911A1
Authority
CA
Canada
Prior art keywords
component
dressing
dressing according
water
components
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002525911A
Other languages
French (fr)
Other versions
CA2525911C (en
Inventor
Paul James Davis
Andrew John Austin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Archimed LLP
Original Assignee
Insense Limited
Paul James Davis
Andrew John Austin
Archimed Llp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Insense Limited, Paul James Davis, Andrew John Austin, Archimed Llp filed Critical Insense Limited
Publication of CA2525911A1 publication Critical patent/CA2525911A1/en
Application granted granted Critical
Publication of CA2525911C publication Critical patent/CA2525911C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/38—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates

Abstract

A skin dressing comprises a first dressing component (16) carrying oxidoreductase enzyme in dried condition; and a second dressing component (18) carrying a source of water, such that when the first and second dressing components are placed in fluid communication with each other, water migrates from the second component towards the first comportent and acts to hydrate enzyme carried by the first component, at least at the surface of the first component. The dressing components are kept separate before use, e.g. being sealed in separate sterile, water-impervious packages such as laminated aluminium foil pouches. In use of the dressing, the second dressing component is located on the skin of a human or animal, e.g. over a wound to be treated or on a region of skin to be treated for cosmetic or therapeutic purposes such as for treatment of acne or other skin conditions. The first dressing component is placed on top of the second component in fluid communication therewith. In embodiments comprising only first and second dressing components, the first dressing component is placed in direct contact with the second dressing component. Water from the second component migrates towards the first comportent and acts to hydrate enzyme carried by the first component, at least at points of contact at the interface between the first and second components. Once hydrated, the oxidoreductase enzyme can immediately begin functioning in known manner with beneficial effects.

Claims (27)

1. A skin dressing, comprising a first dressing component carrying oxidoreductase enzyme in dried condition; and a second dressing component carrying a source of water, such that when the first and second dressing components are placed in fluid communication with each other, water migrates from the second component towards the first component and acts to hydrate enzyme carried by the first component, at least at the surface of the first component.
2. A dressing according to claim 1, wherein the oxidoreductase enzyme comprises glucose oxidase.
3. A dressing according to claim 1 or 2, including a source of substrate for the oxidoreductase enzyme.
4. A dressing according to claim 3, wherein the substrate is present in the second dressing component.
5. A dressing according to any one of the preceding claims, including a supply of iodide ions.
6. A dressing according to any one of the preceding claims, wherein the first component and second component are in the form of layers.
7. A dressing according to any one of the preceding claims, wherein the first component comprises a support or carrier carrying enzyme.
8. A dressing according to claim 7, wherein the support or carrier comprises dried hydrogel material.
9. A dressing according to claim 8, wherein the hydrogel comprises hydrophilic polymer material.
10. A dressing according to claim 9, wherein the polymer comprises poly-2-acrylamido-2-methylpropane sulphonic acid and/or salts thereof.
11. A dressing according to claim 9 or 10, wherein the hydrophilic polymer material is present at a concentration of at least 1 % , preferably at least 2 % , more preferably at least % , possibly at least 10 % , by weight based on the total weight of the gel.
12. A dressing according to any one of the preceding claims, wherein the second dressing component comprises a support or carrier carrying water.
13. A dressing according to claim 12, wherein the second component comprises a hydrated hydrogel.
14. A dressing according to claim 13, wherein the hydrated hydrogel comprises poly(-2-acrylamido-2-methylpropane sulphonic acid) and/or salts thereof.
15. A dressing according to claim 14, wherein the second component comprises a hydrated hydrogel comprising 20% by weight of poly(-2-acrylamido-2-methylpropane sulphonic acid) and/or a salt or salts.
16. A dressing according to claim 13, 14 or 15, wherein the hydrated hydrogel contains at least 30% by weight water.
17. A dressing according to claim 15, wherein the hydrated hydrogel contains about 60% by weight of water.
18. A dressing according to any one of the preceding claims, wherein the first and second components both include gel supports comprising the same polymer.
19. A dressing according to any one of the preceding claims, wherein the first and second components both include polymers that are functionally similar to each other in terms of hydration and water binding behaviour.
20. A dressing according to claim 19, wherein where the second component includes a support of poly(-2-acrylamido-2-methylpropane sulphonic acid) and/or a salt or salts thereof, and the first component includes polyvinyl alcohol.
21. A dressing according to any one of the preceding claims, wherein the first component includes monomers that are identical or similar to monomers from which a polymeric support of the second component is formed.
22. A dressing according to any one of the preceding claims, wherein the first dressing component includes one or more hydration enhancers.
23. A dressing according to claim 22, wherein the hydration enhancer is selected from dried sugars, especially sucrose and trehalose, glycerol and sorbitol.
24. A dressing according to any one of the preceding claims, wherein the first component comprises a support of dried hydrogel formed from 10% by weight poly(-2-acrylamido-2-methylpropane sulphonic) acid and/or a salt or salts thereof, carrying enzyme, and the second component comprises a support of hydrated hydrogel comprising 20% by weight of poly(-2-acrylamido-2-methylpropane sulphonic acid) and/or a salt or salts thereof.
25. A dressing according to any one of the preceding claims, wherein the first and/or second component includes one or more moisturiser materials.
26. A dressing according to any one of the preceding claims, including a covering or outer layer for adhering the dressing to the skin of a human or animal subject.
27. A dressing according to any one of the preceding claims, wherein the first and second components are separately sealed in respective packages prior to use.
CA2525911A 2003-06-09 2004-06-04 Skin dressings containing oxidoreductase enzyme Expired - Fee Related CA2525911C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0313217.2 2003-06-09
GBGB0313217.2A GB0313217D0 (en) 2003-06-09 2003-06-09 Improvements in or relating to skin dressings
PCT/GB2004/002374 WO2004108176A1 (en) 2003-06-09 2004-06-04 Skin dressings containing oxidoreductase enzyme

Publications (2)

Publication Number Publication Date
CA2525911A1 true CA2525911A1 (en) 2004-12-16
CA2525911C CA2525911C (en) 2012-01-10

Family

ID=27589705

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2525911A Expired - Fee Related CA2525911C (en) 2003-06-09 2004-06-04 Skin dressings containing oxidoreductase enzyme

Country Status (12)

Country Link
US (1) US7927588B2 (en)
EP (1) EP1631328B1 (en)
JP (1) JP2006527044A (en)
AT (1) ATE355862T1 (en)
AU (1) AU2004244803B2 (en)
CA (1) CA2525911C (en)
DE (1) DE602004005188T2 (en)
DK (1) DK1631328T3 (en)
ES (1) ES2282868T3 (en)
GB (1) GB0313217D0 (en)
PT (1) PT1631328E (en)
WO (1) WO2004108176A1 (en)

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Also Published As

Publication number Publication date
EP1631328A1 (en) 2006-03-08
ES2282868T3 (en) 2007-10-16
ATE355862T1 (en) 2007-03-15
DK1631328T3 (en) 2007-07-09
DE602004005188D1 (en) 2007-04-19
EP1631328B1 (en) 2007-03-07
US7927588B2 (en) 2011-04-19
AU2004244803B2 (en) 2007-10-11
PT1631328E (en) 2007-08-07
CA2525911C (en) 2012-01-10
WO2004108176A1 (en) 2004-12-16
DE602004005188T2 (en) 2007-11-08
US20060275350A1 (en) 2006-12-07
AU2004244803A1 (en) 2004-12-16
JP2006527044A (en) 2006-11-30
GB0313217D0 (en) 2003-07-16

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