CA2522133A1 - Novel glue for cartilage repair - Google Patents
Novel glue for cartilage repair Download PDFInfo
- Publication number
- CA2522133A1 CA2522133A1 CA002522133A CA2522133A CA2522133A1 CA 2522133 A1 CA2522133 A1 CA 2522133A1 CA 002522133 A CA002522133 A CA 002522133A CA 2522133 A CA2522133 A CA 2522133A CA 2522133 A1 CA2522133 A1 CA 2522133A1
- Authority
- CA
- Canada
- Prior art keywords
- cartilage
- sterile
- implant material
- allograft
- milled
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0069—Three-dimensional shapes cylindrical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
- A61F2310/00383—Gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
Abstract
The invention is directed toward a sterile cartilage defect implant material comprising milled lyophilized allograft cartilage pieces ranging from 0.01 mm to 1.0 mm in size in a bioabsorbable carrier taken from a group consisting of sodium hyaluronate, hyaluronic acid and its derivatives, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran or polymers with allogenic chondrocytes or bone marrow cells in an amount exceeding the natural occurrence of same in hyaline cartilage and adding a cell growth additive.
Claims (23)
1. A sterile allograft cartilage defect implant material comprising milled allograft cartilage pieces lyophilized so that their water content ranges from about 0.1% to about 8.0% in a bioabsorbable carrier.
2. A sterile allograft cartilage defect implant material as claimed in claim 1 wherein said milled cartilage pieces are sized less than 1mm.
3. A sterile allograft cartilage defect implant material as claimed in claim 1 wherein said milled cartilage ranges from about 25% to about 50% by weight and said carrier ranges from about 75% to about 50% by weight.
4. A sterile allograft cartilage defect implant material as claimed in claim 1 wherein said milled cartilage ranges from about 15% to about 30% by weight with the carrier ranging from about 85% to about 70% by weight.
5. A sterile allograft cartilage defect implant material as claimed in claim 1 wherein said carrier is sodium hyaluronate and its derivatives.
6. A sterile allograft cartilage defect implant material as claimed in claim 1 wherein said implant material includes a protein glue.
7. A sterile allograft cartilage defect implant material as claimed in claim 1 wherein said implant material includes autologous chondrocytes in a concentration exceeding the concentration of chondrocytes naturally occurring in the patient.
8, A sterile allograft cartilage defect implant material as claimed in claim 1 wherein said milled cartilage is hyaline cartilage.
9. A sterile allograft cartilage defect implant material as claimed in claim 1 wherein said milled cartilage is fibrous cartilage.
10. A sterile allograft cartilage defect implant material as claimed in claim 1 wherein said milled cartilage is hyaline and fibrous cartilage.
11. A sterile allograft cartilage defect implant material claimed in claim 1 including an additive to said material consisting of one or more of a group consisting of growth factors, human allogenic cells, human allogenic bone marrow cells, human autologous bone marrow cells, human allogenic stem cells, human autologous stem cells, human demineralized bone matrix, and insulin.
12 A sterile cartilage repair material as claimed in claim 11 wherein said growth factors are one or more of a group consisting of FGF-2, FGF-5, IGF-1, TGF-.beta., BMP-2, BMP-7, PDGF, VEGF.
13 A sterile allograft cartilage defect implant material as claimed in claim 1 wherein said carrier comprises one or more of a bioabsorbable carriers taken from a group consisting of sodium hyaluronate, hyaluronic acid and its derivatives, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran or polymers.
14. A sterile cartilage defect implant material comprising milled allograft articular cartilage pieces ranging from 0.01 mm to 1.0 mm in size in a bioabsorbable carrier taken from a group consisting of sodium hyaluronate, hyaluronic acid and its derivatives, gelatin, collagen, chitosan, alginate, buffered PBS, Dextrin or polymers and allogenic chondrocytes in an amount exceeding the natural occurrence of same in articular cartilage.
15. A sterile cartilage defect implant material as claimed in claim 14 wherein said allograft articular cartilage is hyaline cartilage.
16. A sterile cartilage defect material as claimed in claim 14 wherein said cartilage pieces have been lyophilized to have a water content ranging from about 0.1% to 8.0%.
17. A sterile cartilage defect repair material as claimed in claim 14 including an additive in said implant material which consists of one or more of a group consisting of growth factors consisting of one or more of a group consisting of FGF-2, FGF-5, IGF-1, TGF-.beta., BMP-2, BMP-7, PDGF, VEGF, human allogenic cells, autologous chondrocytes, demineralized bone matrix, and insulin.
18. A sterile cartilage defect implant material as claimed in claim 14 wherein said milled cartilage ranges from about 25% to about 50% by weight and said carrier ranges from about 75%
to about 50% by weight.
to about 50% by weight.
19. A sterile cartilage defect implant material as claimed in claim 14 wherein said milled cartilage ranges from about 15% to about 30% by weight with the carrier ranging from about 85%
to about 70% by weight.
to about 70% by weight.
20. A sterile cartilage defect implant material comprising lyophilized milled allograft articular cartilage pieces ranging from 0.01 mm to 1.0 mm in size in a bioabsorbable carrier taken from a group consisting of sodium hyaluronate, hyaluronic acid and its derivatives, gelatin, collagen, chitosan, alginate, buffered PBS, Dextran or polymers and autologous stem cells in an amount exceeding the natural occurrence of same in a patient being treated.
21. A method of placing a cartilage defect material in a cartilage defect, said material comprising allograft articular cartilage which has been lyophilized and mixed in a bioabsorbable carrier comprising the steps of:
(a) cutting patient tissue at a site of a cartilage defect to remove the diseased area of cartilage;
(b) adding autologous cells to said mixture of milled allograft cartilage in a bioabsorbable carrier;
(c) placing a mixture of milled allograft cartilage in a bioabsorbable carrier in the area where cartilage has been removed;
(d) placing a cover over the mixture of milled allograft cartilage in a bioabsorbable carrier to contain the mixture in cartilage defect site for a predetermined period of time.
(a) cutting patient tissue at a site of a cartilage defect to remove the diseased area of cartilage;
(b) adding autologous cells to said mixture of milled allograft cartilage in a bioabsorbable carrier;
(c) placing a mixture of milled allograft cartilage in a bioabsorbable carrier in the area where cartilage has been removed;
(d) placing a cover over the mixture of milled allograft cartilage in a bioabsorbable carrier to contain the mixture in cartilage defect site for a predetermined period of time.
22. The method of claim 21 wherein growth factors are added to said cartilage defect material, said growth factors comprising of one or more of a group consisting of FGF-2, FGF-5, IGF-1, TGF-.beta., BMP-2, BMP-7, PDGF, and VEGF.
23. The method of claim 21 wherein said cells are one or more of a group consisting of chondrocytes, bone marrow cells, and stem cells.
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US56661804P | 2004-04-30 | 2004-04-30 | |
US11/081,103 US20060210643A1 (en) | 2003-04-29 | 2005-03-16 | Cartilage repair mixture containing allograft chondrocytes |
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CA2522133C CA2522133C (en) | 2010-11-16 |
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EP (2) | EP1618178B1 (en) |
AT (1) | ATE401090T1 (en) |
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- 2004-04-21 AT AT04749924T patent/ATE401090T1/en not_active IP Right Cessation
- 2004-04-21 ES ES04749924T patent/ES2310743T3/en not_active Expired - Lifetime
- 2004-04-21 EP EP04749924A patent/EP1618178B1/en not_active Expired - Lifetime
- 2004-04-21 CA CA2522133A patent/CA2522133C/en not_active Expired - Lifetime
- 2004-04-21 WO PCT/US2004/010956 patent/WO2004096983A2/en active Application Filing
- 2004-04-21 DE DE602004015093T patent/DE602004015093D1/en not_active Expired - Lifetime
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2005
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2008
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2010
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2011
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US10245306B2 (en) | 2012-11-16 | 2019-04-02 | Isto Technologies Ii, Llc | Flexible tissue matrix and methods for joint repair |
US10167447B2 (en) | 2012-12-21 | 2019-01-01 | Zimmer, Inc. | Supports and methods for promoting integration of cartilage tissue explants |
US10179191B2 (en) | 2014-10-09 | 2019-01-15 | Isto Technologies Ii, Llc | Flexible tissue matrix and methods for joint repair |
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ES2310743T3 (en) | 2009-01-16 |
USRE43258E1 (en) | 2012-03-20 |
AU2004235291B2 (en) | 2009-01-22 |
CA2563082C (en) | 2012-07-10 |
ATE401090T1 (en) | 2008-08-15 |
CA2563082A1 (en) | 2005-11-24 |
WO2004096983A2 (en) | 2004-11-11 |
EP1740121A2 (en) | 2007-01-10 |
WO2004096983A3 (en) | 2005-12-22 |
CA2522133C (en) | 2010-11-16 |
US20040219182A1 (en) | 2004-11-04 |
US20060210643A1 (en) | 2006-09-21 |
US7067123B2 (en) | 2006-06-27 |
WO2005110278A2 (en) | 2005-11-24 |
USRE42208E1 (en) | 2011-03-08 |
WO2005110278A3 (en) | 2006-08-10 |
US20110196508A1 (en) | 2011-08-11 |
EP1618178A4 (en) | 2006-07-26 |
AU2004235291A1 (en) | 2004-11-11 |
AU2005244247A1 (en) | 2005-11-24 |
EP1618178B1 (en) | 2008-07-16 |
US20080133008A1 (en) | 2008-06-05 |
EP1740121A4 (en) | 2011-06-01 |
US20140058527A1 (en) | 2014-02-27 |
DE602004015093D1 (en) | 2008-08-28 |
EP1618178A2 (en) | 2006-01-25 |
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