CA2517444A1 - Products and methods for brachytherapy - Google Patents
Products and methods for brachytherapy Download PDFInfo
- Publication number
- CA2517444A1 CA2517444A1 CA002517444A CA2517444A CA2517444A1 CA 2517444 A1 CA2517444 A1 CA 2517444A1 CA 002517444 A CA002517444 A CA 002517444A CA 2517444 A CA2517444 A CA 2517444A CA 2517444 A1 CA2517444 A1 CA 2517444A1
- Authority
- CA
- Canada
- Prior art keywords
- radioactive
- spacer members
- seeds
- spacer
- radioactive seeds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1027—Interstitial radiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N2005/1019—Sources therefor
- A61N2005/1023—Means for creating a row of seeds, e.g. spacers
Abstract
A radioactive member for use in brachytherapy comprising a hollow elongate bioabsorbable suture member with radioactive seeds and spacer members without different coloration and diameter from the radioactive seeds alternately disposed therein, and methods for the manufacture and the use thereof. The radioactive members may be used in the treatment of, for example, prostate cancer.
Claims (27)
1. A radioactive member for use in brachytherapy comprising a hollow elongate bioabsorbable suture member with a plurality of radioactive seeds and spacer members disposed alternately therein, wherein the spacer members are dyed with a different color from that of the undyed radioactive seeds and of different diameter from that of the radioactive seeds.
2. A radioactive member of claim1, wherein the diameter of the spacer member is 0.1mm to 0.5 mm smaller than that of the radioactive seeds.
3. A radioactive member of claim 1, wherein the spacer member is dyed with violet.
4. A radioactive member as claimed in claim 1 wherein the suture member comprises poly(glycolic acid), poly(lactic acid), a polyester amide of glycolic or lactic acid, or a polydioxanone.
5. A radioactive member as claimed in claim 1 wherein the carrier material has a substantially circular cross section.
6. A radioactive member as claimed in claim 1 characterised in that the cross section of the carrier has at least one flat surface.
7. A radioactive member as claimed in claim 1 wherein the carrier has a substantially polygonal cross-section and is, preferably, substantially octagonal, square or triangular.
8. A radioactive member as claimed in claim 1 wherein the carrier comprises ultrasound reflecting particles or bubbles of gas.
9. A radioactive member for use in brachytherapy comprising a hollow elongate bioabsorbable suture member with one or more slots therein in which one or more radioactive seeds and spacer members are disposed alternately in a spaced relationship, wherein the spacer members are dyed with a different color from that of the undyed radioactive seeds and of different diameter from that of the radioactive seeds.
10. A method for the production of a radioactive member for use in brachytherapy comprising an elongate, bioabsorbable suture member with radioactive seeds and spacer members disposed alternately therein, said method comprising the steps of:
a) providing a hollow bioabsorbable suture member, providing a plurality of radioactive seeds;
c) providing a plurality of bioabsorbable spacer members, wherein the spacer members are dyed with a different color from that of the undyed radioactive seeds and of different diameter from that of radioactive seeds;
d) heating the radioactive sources to a temperature above the melting or softening temperature of the suture material;
e) placing the heated sources and spacer members alternately onto the suture memberin a predetermined pattern whereby the suture membermelts or deforms around each source and spacer member; and f) cooling the suture member such that it solidifies or hardens about each source and spacer member so as to securely retain each source in place.
a) providing a hollow bioabsorbable suture member, providing a plurality of radioactive seeds;
c) providing a plurality of bioabsorbable spacer members, wherein the spacer members are dyed with a different color from that of the undyed radioactive seeds and of different diameter from that of radioactive seeds;
d) heating the radioactive sources to a temperature above the melting or softening temperature of the suture material;
e) placing the heated sources and spacer members alternately onto the suture memberin a predetermined pattern whereby the suture membermelts or deforms around each source and spacer member; and f) cooling the suture member such that it solidifies or hardens about each source and spacer member so as to securely retain each source in place.
11. A method of claim 10, wherein the diameter of the spacer member is 0.1mm to 0.5 mm smaller than that of the radioactive seeds.
12. A method of claim 10, wherein the color of the spacer member is dyed with violet.
13. A method of claim 10, further comprising a step of sterilizing the radioactive member.
14. A method for the production of a radioactive member for use in brachytherapy comprising a hollow elongate bioabsorbable suture member with radioactive seeds and spacer members disposed alternately therein, said method comprising the steps of:
a) providing an elongate preferably single stranded bioabsorbable suture member which is at a temperature above its melting or softening temperature, b) providing a plurality of radioactive seeds, c) providing a plurality of bioabsorbable spacer members, wherein the spacer members dyed with a different color from that of the undyed radioactive seeds and of different diameter from that of the radioactive seeds;
d) optionally heating the radioactive seeds and/or spacer members to a temperature above the melting or softening temperature of the suture member;
e) alternately placing the (optionally heated) radioactive seeds and spacer members onto the suture member whereby the suture member melts or deforms around the radioactive seeds and spacer members; and f) cooling the suture member such that it solidifies or hardens about each source and spacer member so as to securely retain each radioactive seeds and spacer member in place.
a) providing an elongate preferably single stranded bioabsorbable suture member which is at a temperature above its melting or softening temperature, b) providing a plurality of radioactive seeds, c) providing a plurality of bioabsorbable spacer members, wherein the spacer members dyed with a different color from that of the undyed radioactive seeds and of different diameter from that of the radioactive seeds;
d) optionally heating the radioactive seeds and/or spacer members to a temperature above the melting or softening temperature of the suture member;
e) alternately placing the (optionally heated) radioactive seeds and spacer members onto the suture member whereby the suture member melts or deforms around the radioactive seeds and spacer members; and f) cooling the suture member such that it solidifies or hardens about each source and spacer member so as to securely retain each radioactive seeds and spacer member in place.
15. A method for the production of a radioactive member for use in brachytherapy comprising a hollow elongate bioabsorbable suture member with radioactive seeds and spacer members disposed alternately therein, said method comprising the steps of:
a) providing an elongate preferably single stranded bioabsorbable suture member having a longitudinal groove or slot therein;
b) providing a plurality of radioactive seeds, c) providing a plurality of bioabsorbable spacer members, wherein the spacer members dyed with a different color from that of the undyed radioactive seeds and of different diameter from that of the radioactive seeds;
d) placing the radioactive seeds and the spacer members sequentially or concurrently into the groove in the suture member such that the radioactive seeds and the spacer members are securely retained within the groove.
a) providing an elongate preferably single stranded bioabsorbable suture member having a longitudinal groove or slot therein;
b) providing a plurality of radioactive seeds, c) providing a plurality of bioabsorbable spacer members, wherein the spacer members dyed with a different color from that of the undyed radioactive seeds and of different diameter from that of the radioactive seeds;
d) placing the radioactive seeds and the spacer members sequentially or concurrently into the groove in the suture member such that the radioactive seeds and the spacer members are securely retained within the groove.
16. A method as claimed in claim 15 wherein the radioactive seeds and the spacer members are retained in the groove using a biocompatible adhesive or resin.
17. A method as claimed in claim 15 wherein the radioactive seeds and the spacer members are retained in the groove by means of one or more rails, lips, tabs or knobs.
18. A method of claim 15, wherein it further comprises a step of providing means to apply an external force to deform the edges of the groove around the radioactive seeds and the spacer members such that each radioactive seed and spacer member are securely retained in the groove.
19. A method of claim 18, wherein the means comprises a heated plate, baffle, flange, wheel or roller.
20. A method of claim 19 wherein the means comprises a concave surface.
21. A method of treatment of a condition which is responsive to radiation therapy which comprises the placement of a radioactive member of claim1 disposed therein at or adjacent the site to be treated within a patient for a sufficient period of time to deliver a therapeutically effective dose.
22. A method of treatment of claim 21 wherein the condition to treated is prostate cancer.
23. A method of claim 22 wherein the radioactive member is visualized using a suitable imaging technique in connection with real-time dosimetry equipment.
24. A method of claim 23 wherein the imaging technique comprises ultrasound imaging.
25. A radioactive member of claim 1 loaded onto a wheel or a jig.
26. A radioactive member of claim 25 wherein the wheel or jig is shielded.
27. A method of using a radioactive member for brachytherapy, said method comprising:
a) cutting the radioactive member at one of the spacer members to a prescribed length according to the prescribed implant plan;
b) inserting the cut radioactive member into a hub end of a hollow insertion needle suitable for insertion into a prescribe treatment area, so that the entire radioactive member is inside the needle;
c) pushing the radioactive member through the hollow insertion needle with a needle stylet, until the leading tip of the radioactive member reaches a needle plugging media;
d) inserting the loaded insertion needle into the prescribed treatment area of a patient;
e) removing the insertion needle from around the radioactive member, leaving the radioactive member in the prescribed treatment area of the patient.
2g. A method of using a radioactive member for brachytherapy, said method comprising:
a) inserting an insertion needle into a prescribed treatment area of a patient;
b) cutting the radioactive member at one of the spacer members to a prescribed length according to the prescribed implant plan;
c) loading the radioactive member into an after-loading device;
d) transferring the radioactive member in the after-loading device to the insertion needle where it mates into the insertion needle hub;
e) applying a stylet to advance the radioactive member through the after-loading device into the insertion needle, and finally into the patient;
f) removing the insertion needle and the after-loading device.
a) cutting the radioactive member at one of the spacer members to a prescribed length according to the prescribed implant plan;
b) inserting the cut radioactive member into a hub end of a hollow insertion needle suitable for insertion into a prescribe treatment area, so that the entire radioactive member is inside the needle;
c) pushing the radioactive member through the hollow insertion needle with a needle stylet, until the leading tip of the radioactive member reaches a needle plugging media;
d) inserting the loaded insertion needle into the prescribed treatment area of a patient;
e) removing the insertion needle from around the radioactive member, leaving the radioactive member in the prescribed treatment area of the patient.
2g. A method of using a radioactive member for brachytherapy, said method comprising:
a) inserting an insertion needle into a prescribed treatment area of a patient;
b) cutting the radioactive member at one of the spacer members to a prescribed length according to the prescribed implant plan;
c) loading the radioactive member into an after-loading device;
d) transferring the radioactive member in the after-loading device to the insertion needle where it mates into the insertion needle hub;
e) applying a stylet to advance the radioactive member through the after-loading device into the insertion needle, and finally into the patient;
f) removing the insertion needle and the after-loading device.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/390,506 | 2003-03-17 | ||
| US10/390,506 US7322928B2 (en) | 2003-03-17 | 2003-03-17 | Products and methods for brachytherapy |
| PCT/US2004/008084 WO2004082762A1 (en) | 2003-03-17 | 2004-03-17 | Products and methods for brachytherapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2517444A1 true CA2517444A1 (en) | 2004-09-30 |
| CA2517444C CA2517444C (en) | 2012-06-19 |
Family
ID=32987545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2517444A Expired - Fee Related CA2517444C (en) | 2003-03-17 | 2004-03-17 | Products and methods for brachytherapy |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US7322928B2 (en) |
| EP (1) | EP1610867B1 (en) |
| JP (1) | JP4846565B2 (en) |
| CN (1) | CN100581618C (en) |
| AT (1) | ATE541613T1 (en) |
| BR (1) | BRPI0407970B8 (en) |
| CA (1) | CA2517444C (en) |
| DK (1) | DK1610867T3 (en) |
| ES (1) | ES2377403T3 (en) |
| MX (1) | MXPA05009802A (en) |
| WO (1) | WO2004082762A1 (en) |
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| US6761680B2 (en) * | 2001-11-02 | 2004-07-13 | Richard A. Terwilliger | Delivery system and method for interstitial radiation therapy using seed strands constructed with preformed strand housing |
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| WO2007053823A2 (en) * | 2005-10-31 | 2007-05-10 | Biolucent, Inc. | Brachytherapy apparatus and methods of using same |
| US7988611B2 (en) * | 2006-05-09 | 2011-08-02 | Biocompatibles Uk Limited | After-loader for positioning implants for needle delivery in brachytherapy and other radiation therapy |
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| US7874976B1 (en) | 2006-09-07 | 2011-01-25 | Biocompatibles Uk Limited | Echogenic strands and spacers therein |
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| EP2293842B1 (en) | 2008-05-02 | 2020-08-12 | Civatech Oncology | Brachytherapy devices and related methods |
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| CN109173092A (en) * | 2018-09-25 | 2019-01-11 | 天津赛德医药研究院有限公司 | It is a kind of easily from the Inner irradiation device taken out in vivo |
| CN109513117A (en) * | 2018-09-25 | 2019-03-26 | 天津赛德生物制药有限公司 | Easily easily from the Inner irradiation device taken out in vivo |
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-
2003
- 2003-03-17 US US10/390,506 patent/US7322928B2/en active Active
-
2004
- 2004-03-17 JP JP2006507253A patent/JP4846565B2/en not_active Expired - Fee Related
- 2004-03-17 MX MXPA05009802A patent/MXPA05009802A/en active IP Right Grant
- 2004-03-17 WO PCT/US2004/008084 patent/WO2004082762A1/en active Application Filing
- 2004-03-17 CA CA2517444A patent/CA2517444C/en not_active Expired - Fee Related
- 2004-03-17 DK DK04757539.4T patent/DK1610867T3/en active
- 2004-03-17 ES ES04757539T patent/ES2377403T3/en not_active Expired - Lifetime
- 2004-03-17 AT AT04757539T patent/ATE541613T1/en active
- 2004-03-17 BR BRPI0407970A patent/BRPI0407970B8/en not_active IP Right Cessation
- 2004-03-17 EP EP04757539A patent/EP1610867B1/en not_active Expired - Lifetime
- 2004-03-17 CN CN200480007120A patent/CN100581618C/en not_active Expired - Fee Related
-
2007
- 2007-12-19 US US11/959,687 patent/US8007427B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0407970B1 (en) | 2015-11-24 |
| JP2006520644A (en) | 2006-09-14 |
| EP1610867B1 (en) | 2012-01-18 |
| ATE541613T1 (en) | 2012-02-15 |
| WO2004082762A1 (en) | 2004-09-30 |
| BRPI0407970B8 (en) | 2021-06-22 |
| JP4846565B2 (en) | 2011-12-28 |
| CN1761500A (en) | 2006-04-19 |
| US7322928B2 (en) | 2008-01-29 |
| US20080097140A1 (en) | 2008-04-24 |
| BRPI0407970A (en) | 2006-03-07 |
| CA2517444C (en) | 2012-06-19 |
| US20040186340A1 (en) | 2004-09-23 |
| ES2377403T3 (en) | 2012-03-27 |
| MXPA05009802A (en) | 2005-10-26 |
| CN100581618C (en) | 2010-01-20 |
| EP1610867A1 (en) | 2006-01-04 |
| DK1610867T3 (en) | 2012-03-19 |
| US8007427B2 (en) | 2011-08-30 |
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