CA2516343A1 - Dual-chamber type prefilled syringe - Google Patents

Dual-chamber type prefilled syringe Download PDF

Info

Publication number
CA2516343A1
CA2516343A1 CA002516343A CA2516343A CA2516343A1 CA 2516343 A1 CA2516343 A1 CA 2516343A1 CA 002516343 A CA002516343 A CA 002516343A CA 2516343 A CA2516343 A CA 2516343A CA 2516343 A1 CA2516343 A1 CA 2516343A1
Authority
CA
Canada
Prior art keywords
plug member
cylindrical body
chamber
bypass
rear end
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002516343A
Other languages
French (fr)
Other versions
CA2516343C (en
Inventor
Masahiko Kato
Yasaburo Akagi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Pharmaceutical Company Limited
Masahiko Kato
Yasaburo Akagi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32911398&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2516343(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical Company Limited, Masahiko Kato, Yasaburo Akagi filed Critical Takeda Pharmaceutical Company Limited
Publication of CA2516343A1 publication Critical patent/CA2516343A1/en
Application granted granted Critical
Publication of CA2516343C publication Critical patent/CA2516343C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M2005/3132—Syringe barrels having flow passages for injection agents at the distal end of the barrel to bypass a sealing stopper after its displacement to this end due to internal pressure increase

Abstract

A two chamber-type pre-filled syringe where a first chamber and a second chamber are formed by sealingly installing in a tube body a front plug body, a middle plug body, and an end plug body. A bypass (14) is formed in the inner face of a tube body (2). A first chamber (9) and a second chamber (10) are first communicated with each other through the bypass (14) when a middle plug body (7) moves to the position where the bypass (14) is formed. In a state at this position, or a liquid-movement start state (S), the volume (VS) in the tube body between a fore end (2a) of the tube body (2) and a rear end (6b) of a front plug body (6) is set to be 60% or more of the volume (VC) of a second received-component (12). This prevents, when a liquid-like received-component in the second chamber flows into the first chamber, a portion of the liquid-like received-component from passing through the first chamber and reaching a needle installation portion at the tip of the tube body.

Claims (4)

1. A dual-chamber type prefilled syringe comprising a cylindrical body (2) which has a first end (2a) provided with an portion (3) for attaching an injection needle, a front plug member (6), a middle plug member (7) and an end plug member (8) being hermetically fitted within the cylindrical body (2) in the mentioned order from a side of the first end (2a) of the cylindrical body (2), a first chamber (9) being formed between the front plug member (6) and the middle plug member (7) within the cylindrical body (2) and accommodating a first component (11), a second chamber (10) being formed between the middle plug member (7) and the end plug member (8) within the cylindrical body (2) and accommodating a second component (12), the front plug member (6) and the middle plug member (7) having rear ends (6b and 7b), respectively on a side far away from the first leading end (2a), the cylindrical body (2) having an inner surface formed with a bypass (14) in the shape of a concaved groove, the bypass (14) being longer than the middle plug member (7) along an axial direction of the cylindrical body (2) and having a rear end portion (19) on the side far away from the first end (2a), the first chamber (9) being communicated with the second chamber (10) via the bypass (14) when the middle plug member (7) moves toward the side of the first end (2a) to reach a position where the bypass (14) is formed, characterized in that:
an inner volume (VS) of the cylindrical body (2) between the first end (2a) of the cylindrical body (2) and the rear end (6b) of the front plug member (6) when the middle plug member (7) has moved toward the side of the first end (2a) and its rear end (7b) has reached the rear end portion (19) of the bypass (14) is at least 600 of a volume (VC) of the second component (12).
2. The dual-chamber type prefilled syringe as set forth in claim 1, wherein the inner volume (VS) of the cylindrical body (2) between the first end (2a) of the cylindrical body (2) and the rear end (6b) of the front plug member (6) when the rear end (7b) of the middle plug member (7) has reached the rear end portion (19) of the bypass (14) is not more than the volume (VC) of the second component (12).
3. The dual-chamber type prefilled syringe as set forth in claim 1 or 2, wherein a spacing (L) between the first end (2a) of the cylindrical body (2) and the rear end (6b) of the front plug member (6) when the rear end (7b) of the middle plug member (7) has reached the rear end portion (19) of the bypass (14) is not more than 30 mm.
4. The dual-chamber type prefilled syringe as set forth in any one of claims 1 to 3, wherein a length of the middle plug member (7) along an axial direction of the cylindrical body (2) is set to a dimension which is 75 to 100% of an inner diameter of the cylindrical body (2).
CA2516343A 2003-02-19 2004-02-18 Dual-chamber type prefilled syringe Expired - Fee Related CA2516343C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2003040850 2003-02-19
JP2003-040850 2003-02-19
JP2003346718 2003-10-06
JP2003-346718 2003-10-06
PCT/JP2004/001775 WO2004073774A1 (en) 2003-02-19 2004-02-18 Two chamber-type pre-filled syringe

Publications (2)

Publication Number Publication Date
CA2516343A1 true CA2516343A1 (en) 2004-09-02
CA2516343C CA2516343C (en) 2011-10-11

Family

ID=32911398

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2516343A Expired - Fee Related CA2516343C (en) 2003-02-19 2004-02-18 Dual-chamber type prefilled syringe

Country Status (6)

Country Link
US (1) US7311692B2 (en)
EP (1) EP1598088B1 (en)
JP (1) JP4884769B2 (en)
CA (1) CA2516343C (en)
ES (1) ES2530517T3 (en)
WO (1) WO2004073774A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7998106B2 (en) 2004-05-03 2011-08-16 Thorne Jr Gale H Safety dispensing system for hazardous substances
SE0401569D0 (en) * 2004-06-17 2004-06-17 Gambro Lundia Ab applicator
CN100368030C (en) * 2005-11-30 2008-02-13 湖南千山制药机械股份有限公司 Two-chamber prefilled syringe and its prefilling method
JP2008259704A (en) * 2007-04-12 2008-10-30 Hisamitsu Pharmaceut Co Inc Prefilled syringe
US20080275387A1 (en) * 2007-05-03 2008-11-06 Yeadon Stephen C Hemostatic medical device
JP5435550B2 (en) * 2009-04-27 2014-03-05 日本ケミカルリサーチ株式会社 Two-chamber container mixing device
US9156589B2 (en) 2010-04-15 2015-10-13 Alberto Fernandez de Castro Manually activated reconstituting container
JP4757951B1 (en) * 2010-10-19 2011-08-24 株式会社アルテ Two-chamber syringe
US8870028B2 (en) 2012-05-25 2014-10-28 Restek Corporation Dispensing device
JP5081330B1 (en) 2012-06-20 2012-11-28 株式会社アルテ Syringe manufacturing cartridge set and two-chamber container-use syringe manufacturing method
WO2014093926A1 (en) 2012-12-14 2014-06-19 Larson Bryan Dual medicament carpule for dental syringes
JP5437510B1 (en) * 2013-02-15 2014-03-12 株式会社アルテ Two-chamber syringe
USD755957S1 (en) 2013-12-13 2016-05-10 Bryan Larson Dental carpule
BR112017011464A2 (en) 2014-12-08 2018-02-27 Genentech, Inc. drug delivery devices and methods of manufacturing a device
US9833572B2 (en) 2015-01-19 2017-12-05 Michael E. Berend Modular dual chamber syringe system
WO2018180458A1 (en) 2017-03-31 2018-10-04 武田薬品工業株式会社 Syringe

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3687530T2 (en) 1985-06-27 1993-07-22 Duphar Int Res SYRINGE.
JPH0614756Y2 (en) * 1991-06-26 1994-04-20 株式会社アルテ Assembled dual chamber syringe
AU665067B2 (en) * 1992-04-30 1995-12-14 Takeda Pharmaceutical Company Limited Prefilled syringe
JP2642582B2 (en) * 1992-04-30 1997-08-20 武田薬品工業株式会社 Prefilled syringe
JPH0614756A (en) 1992-07-02 1994-01-25 Azu Giken:Kk Thawer
JP3940455B2 (en) * 1997-01-30 2007-07-04 武田薬品工業株式会社 Two-chamber syringe
JP3968445B2 (en) * 1997-09-16 2007-08-29 株式会社アルテ Prefilled syringe
JP2002263186A (en) * 2001-03-09 2002-09-17 Takeda Chem Ind Ltd Gasket for bypass type pre-filled syringe
JP4838955B2 (en) * 2001-08-21 2011-12-14 武田薬品工業株式会社 Two-chamber prefilled syringe

Also Published As

Publication number Publication date
US20060189943A1 (en) 2006-08-24
ES2530517T3 (en) 2015-03-03
EP1598088A1 (en) 2005-11-23
CA2516343C (en) 2011-10-11
EP1598088B1 (en) 2014-12-31
JP4884769B2 (en) 2012-02-29
US7311692B2 (en) 2007-12-25
WO2004073774A1 (en) 2004-09-02
EP1598088A4 (en) 2006-05-17
JPWO2004073774A1 (en) 2006-06-01

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20200218