CA2436043A1 - Focusable virtual microscopy apparatus and method - Google Patents

Focusable virtual microscopy apparatus and method Download PDF

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Publication number
CA2436043A1
CA2436043A1 CA002436043A CA2436043A CA2436043A1 CA 2436043 A1 CA2436043 A1 CA 2436043A1 CA 002436043 A CA002436043 A CA 002436043A CA 2436043 A CA2436043 A CA 2436043A CA 2436043 A1 CA2436043 A1 CA 2436043A1
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Prior art keywords
images
image
plane
depth
focusing
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CA002436043A
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French (fr)
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CA2436043C (en
Inventor
James V. Bacus
James W. Bacus
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Olympus America Inc
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Expired - Lifetime legal-status Critical Current

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    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T3/00—Geometric image transformation in the plane of the image
    • G06T3/40—Scaling the whole image or part thereof
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365—Control or image processing arrangements for digital or video microscopes
    • G02B21/367—Control or image processing arrangements for digital or video microscopes providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T3/00—Geometric image transformation in the plane of the image
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1434—Electro-optical investigation, e.g. flow cytometers using an analyser being characterised by its optical arrangement
    • G01N2015/1447—Spatial selection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1434—Electro-optical investigation, e.g. flow cytometers using an analyser being characterised by its optical arrangement
    • G01N2015/1452—Adjustment of focus; Alignment

Abstract

A virtual microscope slide includes images of a specimen for a given level of optical magnification which are associated and stored in a data structure. The forming of the data structure having the multiple Z-plane images preferably includes automatically focusing at a principal reference focal plane and capturing and digitizing an optically magnified reference Z-image and then shifting the specimen relative to the lens system by a predetermined increment to capture and digitize another Z-plane image. Preferably, a multiple sequence of Z-plane images above and below the reference image and captured arid digitized. For ease of retrieval and use, each reference image has its associated Z-plane images are formed in a stack that is sent over the Internet, or Intranet to a local computer storage for quick retrieval when a viewer wants to mimic a focusing up or down to better view a detail in an image. Thus, the resultant images are retrieved and displayed such that a virtual focusing capability is available to the user. The images can be formed with overlapping fields of depth, adjacent fields of depth, or wholly separated fields of depth.
CA002436043A 2002-02-22 2003-02-24 Focusable virtual microscopy apparatus and method Expired - Lifetime CA2436043C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35874702P 2002-02-22 2002-02-22
US60/358,747 2002-02-22
PCT/US2003/005597 WO2003073365A1 (en) 2002-02-22 2003-02-24 Focusable virtual microscopy apparatus and method

Publications (2)

Publication Number Publication Date
CA2436043A1 true CA2436043A1 (en) 2003-08-22
CA2436043C CA2436043C (en) 2006-01-10

Family

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Family Applications (1)

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CA002436043A Expired - Lifetime CA2436043C (en) 2002-02-22 2003-02-24 Focusable virtual microscopy apparatus and method

Country Status (6)

Country Link
US (3) US7596249B2 (en)
EP (1) EP1428169B1 (en)
JP (5) JP5132867B2 (en)
AU (1) AU2003217694A1 (en)
CA (1) CA2436043C (en)
WO (1) WO2003073365A1 (en)

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