CA2420038A1 - Devices for intraocular drug delivery - Google Patents
Devices for intraocular drug delivery Download PDFInfo
- Publication number
- CA2420038A1 CA2420038A1 CA002420038A CA2420038A CA2420038A1 CA 2420038 A1 CA2420038 A1 CA 2420038A1 CA 002420038 A CA002420038 A CA 002420038A CA 2420038 A CA2420038 A CA 2420038A CA 2420038 A1 CA2420038 A1 CA 2420038A1
- Authority
- CA
- Canada
- Prior art keywords
- delivery
- delivery device
- body member
- substance
- eye
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
- A61B2017/00867—Material properties shape memory effect
Abstract
A therapeutic agent delivery device that can allows is particularly suitable for delivery of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. Preferred devices of the inventi on are minimally invasive, refillable and may be easily fixed to the treatment area. Preferred delivery devices of the invention also include those that comprise a non-linear shaped body member housing one or more substances and a delivery mechanism for the sustained delivery of the one or more substances from the non-linear shaped body member to the patient.
Claims (67)
1. An implantable delivery device for intraocular delivery comprising:
a non-linear shaped body member having a proximal end and a distal end;
a lumen extending through the coil shaped body member for housing a substance to be delivered;
a delivery mechanism for delivery of the substance, whereby the non-linear shape of the body member provides an increased surface area per length of the device through which drug delivery occurs.
a non-linear shaped body member having a proximal end and a distal end;
a lumen extending through the coil shaped body member for housing a substance to be delivered;
a delivery mechanism for delivery of the substance, whereby the non-linear shape of the body member provides an increased surface area per length of the device through which drug delivery occurs.
2. The delivery device of claim 1 wherein the member has multiple angles.
3. The delivery device of claim 1 or 2 wherein the body member is coil-shaped.
4. The delivery device of any one of claims 1 through 3 further comprising a port near the proximal end of the non-linear shaped body member for introducing the substance to the lumen.
5. The delivery device of any one of claims 1 through 4 further comprising a rim or cap at the distal end of the device for stabilizing the device at a desired delivery area wherein the non-linear shaped body member in inserted into the eye until the rim or cap abuts the outer surface of the eye.
6. The delivery device of claim 5, wherein the rim or cap includes one ore more holes for suturing the device to the eye.
7. The delivery device of claim 5 or 6 wherein the rim or cap is fabricated of a pliable material.
8. The delivery device of any one of claims 5 through '7 wherein the rim or cap is fabricated of a material selected from, silicone elastomers and rubbers, polyolefins, polyurethanes, acrylates, polycarbonates, polyamides, polyimides, polyesters, and polysulfones.
9. The delivery device of any one of claims 1 through 8 wherein the device comprises a delivery mechanism comprises at least one exit aperture located at the distal end of the non-linear shaped body member.
10. The delivery device of claim 9 wherein the size and/or number of the at least one exit aperture controls the rate of delivery of the substance.
11. The delivery device of claim 9 or 10 further comprising a mechanism for controlling the rate of delivery of the substance through the at least one exit aperture.
12. The delivery device of any one of claims 9 through 11 wherein the mechanism for controlling the rate of delivery of substance comprises a porous lining, a matrix material, a diffusion-limiting material or rate-limiting membrane that covers the at least one exit aperture.
13. The delivery device of any one of claims 1 through 8 wherein the device comprises a delivery mechanism comprises a plurality of openings along the coil shaped body member.
14. The delivery device of claim 13 wherein the size and/or number of the at least one openings controls the rate of delivery of the substance.
15. The delivery device of any one of claims 1 through 8 wherein the device comprises a delivery mechanism comprises a permeable or semi-permeable material forming at least a portion of the non-linear shaped body member.
16. The delivery device of claim 15 wherein the percentage of the non-linear shaped body member fabricated of a permeable or semi-permeable material controls the rate of delivery of the substance.
17. The delivery device of claim 15 wherein the permeability of the material to the substance controls the rate of delivery of the substance.
18. The delivery device of claim 15 wherein the permeable or semi-permeable material is selected from polycarbonates, polyolefins, polyurethanes, copolymers of acrylonitrile, copolymers of polyvinyl chloride, polyamides, polysulphones, polystyrenes, polyvinyl fluorides, polyvinyl alcohols, polyvinyl esters, polyvinyl butyrate, polyvinyl acetate, polyvinylidene chlorides, polyvinylidene fluorides, polyimides, polyisoprene, polyisobutylene, polybutadiene, polyethylene, polyethers, polytetrafluoroethylene, polychloroethers, polymethylmethacrylate, polybutylmethacrylate, polyvinyl acetate, nylons, cellulose, gelatin, silicone rubbers and porous rubbers.
19. The delivery device of any one of claims 1 through 8 wherein the device comprises a delivery mechanism that comprises a biodegradable polymeric material forming at least a portion of the non-linear shaped body member.
20. The delivery device of claim 19 wherein the biodegradable polymeric material contains microparticles of the therapeutic agent to be delivered.
21. The delivery device of any one of claims 1 through 21 wherein the distal end of the body member is adapted for piercing the eye during insertion into the eye.
22. The delivery device of claim 22 wherein the body member distal end is pointed or beveled.
23. The delivery device of any one of claims 1 through 22 wherein the cross-sectional shape of the non-linear shaped body member is circular.
24. The delivery device of any one of claims 1 through 23 wherein the device may be inserted through an incision requiring few or no sutures for closure.
25. The delivery device of claim 24 wherein the largest cross-section dimension of the member is from about 0.25 mm to about 1 mm.
26. The delivery device of claim 24 wherein the largest cross-section dimension of the body member is from about 0.25 mm to about 0.5 mm.
27. The delivery device of any one of claims 1 through 26 wherein the port near the proximal end of the body member forms a seal about the needle of a syringe or injection mechanism used to introduce the substance to the lumen.
28. The delivery device of any one of claims 1 through 26 further comprising a collar mounted about the distal end of the body member through which the needle of a syringe or injection mechanism may be inserted and which forms a seal about the needle of a syringe or injection mechanism.
29. The delivery device of any one of claims 1 through 28 wherein the port near the proximal end of the body member is fabricated of an injectable self-sealing material.
30. The delivery device of claim 29 wherein the injectable self-sealing material is selected from silicone rubber, silicone elastomers and polyolefin.
31. The delivery device of any one of claims 1 through 30 wherein the body member is fabricated of a flexible material that prevents small movements of the delivery device from being translated to the retina.
32. An implantable delivery device for intraocular delivery comprising a coil shaped body member having a proximal end and a distal end.
33. The delivery device of claim 32 wherein at least a portion of the coil shaped body member fabricated of a biodegradable polymeric material containing microparticles of the substance to be delivered, whereby as the polymeric material decomposes, the substance is delivered.
34. An implantable delivery device for intraocular delivery comprising:
a non-linear shaped body member having a proximal end and a distal end; and a plurality of lumens extending through the body member for housing at least one substance to be delivered.
a non-linear shaped body member having a proximal end and a distal end; and a plurality of lumens extending through the body member for housing at least one substance to be delivered.
35. The delivery device of claim 34 wherein the device further comprises a delivery mechanism for delivery of the substance.
36. The delivery device of claim 34 or 35 wherein the body member is coil-shaped.
37. The delivery device of any one of claims 34 through 36 further comprising a plurality of ports, each in fluid communication with a corresponding lumen for introducing the substance to each of the lumens.
38. An ocular drug delivery device comprising:
a non-linear shaped body member that has a shape other than a substantially C-configuration.
a non-linear shaped body member that has a shape other than a substantially C-configuration.
39. The delivery device of any one of claims 1 through 38 wherein the non-linear shaped body member is fabricated of a cluster of hollow tubes formed into a non-linear shape, each tube having a lumen for housing at least one substance to be delivered.
40. The delivery device of claim 39 wherein the lumen is divided into a plurality of compartments along the length of the lumen by at least one impermeable divider.
41. The delivery device of claim 40 wherein a different substance is inserted and housed within each of the plurality of compartments.
42. The delivery device of claim 40 or 41 wherein the plurality of compartments may each be selectively opened by a laser for delivery of the substance within each compartment.
43. The delivery device of any one of claims 1 through 42 further including a backbone extending through at least a portion of the non-linear shaped body member for added structural support of the non-linear shaped body member.
44. The delivery device of any one of claims 32 through 43 wherein the device may be inserted through an incision requiring few or no sutures for closure.
45. The delivery device of claim 44 wherein the largest cross-section dimension of the body member is from about 0.25 mm to about 1 mm.
46. The delivery device of claim 44 wherein the largest cross-section dimension of the body member ranges from about 0.25 mm to about 0.5 mm.
47. The delivery device of any one of claims 1 through 46 wherein at least a portion of the body member is fabricated of a shape memory material, whereby the body member may be deformed into a shape that allows easier insertion of the device into the eye and whereby the device returns to a non-linear remembered shape after insertion in the eye.
48. The delivery device of any one of claims 1 through 47 wherein the body member has a backbone fabricated of a shape memory material, whereby the body member may be deformed into a shape that allows easier insertion of the device into the eye and whereby the device returns to a non-linear remembered shape after insertion in the eye.
49. An implantable delivery device for intraocular delivery comprising:
a body member having a proximal end and a distal end;
at least a portion of the body member fabricated of a shape memory material;
whereby the remembered shape of the body member is non-linear, and whereby the body member may be deformed into a shape that allows easier insertion of the device into the eye and whereby the device returns to its non-linear remembered shape after insertion in the eye.
a body member having a proximal end and a distal end;
at least a portion of the body member fabricated of a shape memory material;
whereby the remembered shape of the body member is non-linear, and whereby the body member may be deformed into a shape that allows easier insertion of the device into the eye and whereby the device returns to its non-linear remembered shape after insertion in the eye.
50. The delivery device of any one of claims claim 47 through 49 wherein the remembered shape of the body member is a coil shape.
51. The delivery device of any one of claims 47 through 50, wherein the shape memory material is selected from shape memory alloys and shape memory polymers.
52. A device for drug delivery comprising:
a body member having a maximum cross-section dimension of from about 0.25 mm to about 1 mm.
a body member having a maximum cross-section dimension of from about 0.25 mm to about 1 mm.
53. The delivery device of claim 53 wherein the maximum cross-section dimension of the body member is from about 0.25 mm to about 0.5 mm.
54. The delivery device of claim 52 wherein the maximum cross-section dimension of the body member is from about 0.25 mm to about 0.4 mm.
55. The delivery device of any one of claims 52 through 54 wherein the device is implantable with a human eye.
56. A medical device kit, comprising one or more of the delivery devices of any one of claims 1 through 55.
57. The kit of claim 56 wherein the one or more delivery devices are packaged in sterile condition.
58. A method for delivery of a therapeutic agent to a patient's eye comprising:
(a) providing a delivery device of any one of claims 1 through 54 wherein the device contains a therapeutic agent; and (b) inserting the device into a patient's eye.
(a) providing a delivery device of any one of claims 1 through 54 wherein the device contains a therapeutic agent; and (b) inserting the device into a patient's eye.
59. The method of claim 58 wherein after insertion of the device, the therapeutic agent enters the patient's eye.
60. The method of claim 58 or 59 wherein the therapeutic agent is administered intraocularly to the patient.
61. A method for delivery of a substance intraocularly, comprising:
(a) providing a sustained release delivery device comprising:
a non-linear shaped body member having a proximal end and a distal end;
a lumen extending through the non-linear shaped body member for housing a substance to be delivered;
a delivery mechanism for delivery of the substance;
(b) making an incision in a patient's eye to access a treatment area;
(c) inserting the delivery device into the treatment area through the incision distal end first;
(d) allowing the substance to travel out of the lumen and to the eye through the delivery mechanism;
(e) removing the delivery device from the treatment area.
(a) providing a sustained release delivery device comprising:
a non-linear shaped body member having a proximal end and a distal end;
a lumen extending through the non-linear shaped body member for housing a substance to be delivered;
a delivery mechanism for delivery of the substance;
(b) making an incision in a patient's eye to access a treatment area;
(c) inserting the delivery device into the treatment area through the incision distal end first;
(d) allowing the substance to travel out of the lumen and to the eye through the delivery mechanism;
(e) removing the delivery device from the treatment area.
62. A method for delivery of a substance intraocularly, comprising:
(a) providing a sustained release delivery device comprising:
a non-linear shaped body member having a proximal end and a distal end;
a lumen extending through the non-linear shaped body member for housing a substance to be delivered;
a delivery mechanism for delivery of the substance;
a port at the distal end of the non-linear shaped body member for injection of the substance into the lumen;
(b) making an incision in a patient's eye to access the treatment area;
(c) inserting the delivery device into the treatment area through the incision distal end first such that the port remains outside the incision;
(d) using an injection mechanism to inject the substance into the lumen through the port;
(e) removing the injection mechanism from the port and closing off the port;
(f) allowing the substance to travel out of the lumen and to the patient through the a delivery mechanism;
(g) optionally repeating steps (d) through (f) one or more times; and (h) removing the delivery device from the treatment area.
(a) providing a sustained release delivery device comprising:
a non-linear shaped body member having a proximal end and a distal end;
a lumen extending through the non-linear shaped body member for housing a substance to be delivered;
a delivery mechanism for delivery of the substance;
a port at the distal end of the non-linear shaped body member for injection of the substance into the lumen;
(b) making an incision in a patient's eye to access the treatment area;
(c) inserting the delivery device into the treatment area through the incision distal end first such that the port remains outside the incision;
(d) using an injection mechanism to inject the substance into the lumen through the port;
(e) removing the injection mechanism from the port and closing off the port;
(f) allowing the substance to travel out of the lumen and to the patient through the a delivery mechanism;
(g) optionally repeating steps (d) through (f) one or more times; and (h) removing the delivery device from the treatment area.
63. The method of claim 58 through 62 wherein the body member is coil-shaped and wherein the step of inserting the delivery device into the treatment area through the incision distal end first comprises twisting the coil-shaped body member in through the incision.
64. A method for delivery of a therapeutic agent comprising inserting a delivery device of any one of claims 1 through 54 into a patient ocular treatment area and allowing the delivery mechanism to deliver the substance to a treatment area at a desired rate.
65. A method for the treatment of ocular conditions in patients comprising utilizing the delivery device of any one of claims 1 through 54 to deliver one or more therapeutic agents to the eye of the patient.
66. The method of any one of claims 58 through 64 wherein at least a portion of the body member is fabricated of a shape memory material, the method further comprising the step of, prior to insertion of the device into the eye, deforming the body member into a shape that allows easier insertion of the device into the eye, whereby after the device is inserted into the eye the device returns to a non-linear remembered shape.
67. The method of claim 65 or 66 wherein the member has a substantially coil configuration.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22893400P | 2000-08-30 | 2000-08-30 | |
US60/228,934 | 2000-08-30 | ||
PCT/US2001/020119 WO2002017831A2 (en) | 2000-08-30 | 2001-06-22 | Devices for intraocular drug delivery |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2420038A1 true CA2420038A1 (en) | 2002-03-07 |
CA2420038C CA2420038C (en) | 2010-11-09 |
Family
ID=22859147
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2420038A Expired - Fee Related CA2420038C (en) | 2000-08-30 | 2001-06-22 | Devices for intraocular drug delivery |
Country Status (11)
Country | Link |
---|---|
US (3) | US6719750B2 (en) |
EP (2) | EP1313415B1 (en) |
JP (1) | JP4471568B2 (en) |
AT (2) | ATE547080T1 (en) |
AU (3) | AU2001271417B2 (en) |
CA (1) | CA2420038C (en) |
DE (1) | DE60135352D1 (en) |
DK (1) | DK1313415T3 (en) |
ES (1) | ES2312456T3 (en) |
PT (1) | PT1313415E (en) |
WO (1) | WO2002017831A2 (en) |
Families Citing this family (295)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW586934B (en) * | 1997-05-19 | 2004-05-11 | Sumitomo Pharma | Immunopotentiating composition |
US9295581B2 (en) * | 1999-01-05 | 2016-03-29 | Second Sight Medical Products, Inc. | Medical tack with a variable effective length |
US6416777B1 (en) * | 1999-10-21 | 2002-07-09 | Alcon Universal Ltd. | Ophthalmic drug delivery device |
US7943162B2 (en) * | 1999-10-21 | 2011-05-17 | Alcon, Inc. | Drug delivery device |
ATE547080T1 (en) | 2000-08-30 | 2012-03-15 | Univ Johns Hopkins | DEVICES FOR INTRAOCULAR DRUG DELIVERY |
CA2432438C (en) * | 2001-01-09 | 2011-04-26 | Microchips, Inc. | Flexible microchip devices for ophthalmic and other applications |
US7181287B2 (en) * | 2001-02-13 | 2007-02-20 | Second Sight Medical Products, Inc. | Implantable drug delivery device |
US6875165B2 (en) * | 2001-02-22 | 2005-04-05 | Retinalabs, Inc. | Method of radiation delivery to the eye |
WO2002100318A2 (en) | 2001-06-12 | 2002-12-19 | Johns Hopkins University School Of Medicine | Reservoir device for intraocular drug delivery |
EP1441799B1 (en) * | 2001-06-18 | 2006-10-11 | Durect Corporation | Device for delivering microdoses of agent to the ear |
DE60214697T2 (en) * | 2001-07-23 | 2007-09-13 | Alcon Inc. | DEVICE FOR RELEASING AN OPHTHALMIC MEDICINAL PRODUCT |
PT1409065E (en) * | 2001-07-23 | 2007-03-30 | Alcon Inc | Ophthalmic drug delivery device |
CA2473355C (en) * | 2002-01-18 | 2012-01-03 | Michael E. Snyder | Sustained release ophthalmological device and method of making and using the same |
US7108685B2 (en) * | 2002-04-15 | 2006-09-19 | Boston Scientific Scimed, Inc. | Patch stabilization of rods for treatment of cardiac muscle |
AU2003217531A1 (en) * | 2002-05-02 | 2003-11-17 | Massachusetts Eye And Ear Infirmary | Ocular drug delivery systems and use thereof |
AU2003244854A1 (en) * | 2002-07-09 | 2004-01-23 | Anglo-European College Of Chiropractic Ltd | Method for imaging the relative motion of skeletal segments |
US7008403B1 (en) * | 2002-07-19 | 2006-03-07 | Cognitive Ventures Corporation | Infusion pump and method for use |
EP1539066B1 (en) * | 2002-09-17 | 2012-11-07 | Iscience Surgical Corporation | Apparatus surgical bypass of aqueous humor |
CA2689424A1 (en) * | 2002-09-29 | 2004-04-08 | Surmodics, Inc. | Methods for treatment and/or prevention of retinal disease |
US7008411B1 (en) * | 2002-09-30 | 2006-03-07 | Advanced Cardiovascular Systems, Inc. | Method and apparatus for treating vulnerable plaque |
US7326238B1 (en) * | 2002-09-30 | 2008-02-05 | Abbott Cardiovascular Systems Inc. | Method and apparatus for treating vulnerable plaque |
US20060265043A1 (en) * | 2002-09-30 | 2006-11-23 | Evgenia Mandrusov | Method and apparatus for treating vulnerable plaque |
WO2004073551A2 (en) * | 2003-02-18 | 2004-09-02 | Massachusetts Eye And Ear Infirmary | Transscleral drug delivery device and related methods |
US8246974B2 (en) * | 2003-05-02 | 2012-08-21 | Surmodics, Inc. | Medical devices and methods for producing the same |
AU2004237774B2 (en) * | 2003-05-02 | 2009-09-10 | Surmodics, Inc. | Implantable controlled release bioactive agent delivery device |
US20040225250A1 (en) | 2003-05-05 | 2004-11-11 | Michael Yablonski | Internal shunt and method for treating glaucoma |
US20040265356A1 (en) * | 2003-06-30 | 2004-12-30 | Bausch & Lomb Incorporated | Drug delivery device |
KR20060082792A (en) * | 2003-07-10 | 2006-07-19 | 알콘, 인코퍼레이티드 | Ophthalmic drug delivery device |
PT1660057E (en) * | 2003-08-27 | 2012-08-02 | Ophthotech Corp | Combination therapy for the treatment of ocular neovascular disorders |
AU2004274026A1 (en) * | 2003-09-18 | 2005-03-31 | Macusight, Inc. | Transscleral delivery |
US20050181018A1 (en) * | 2003-09-19 | 2005-08-18 | Peyman Gholam A. | Ocular drug delivery |
US7291125B2 (en) * | 2003-11-14 | 2007-11-06 | Transcend Medical, Inc. | Ocular pressure regulation |
US7431709B2 (en) * | 2003-12-05 | 2008-10-07 | Innfocus, Llc | Glaucoma implant device |
US20050148948A1 (en) * | 2003-12-19 | 2005-07-07 | Caputa Steven G. | Sutureless ophthalmic drug delivery system and method |
US7976520B2 (en) * | 2004-01-12 | 2011-07-12 | Nulens Ltd. | Eye wall anchored fixtures |
IL159818A0 (en) * | 2004-01-12 | 2004-06-20 | Nulens Ltd | Intraocular structure |
US20050222613A1 (en) * | 2004-02-05 | 2005-10-06 | Edwin Ryan | Wound closure device and method for vitrectomy |
EP1720608B1 (en) | 2004-02-12 | 2010-11-17 | NeoVista, Inc. | Apparatus for intraocular brachytherapy |
US7563222B2 (en) * | 2004-02-12 | 2009-07-21 | Neovista, Inc. | Methods and apparatus for intraocular brachytherapy |
US20060083772A1 (en) * | 2004-04-06 | 2006-04-20 | Dewitt David M | Coating compositions for bioactive agents |
US20050220842A1 (en) * | 2004-04-06 | 2005-10-06 | Dewitt David M | Coating compositions for bioactive agents |
CN1976732A (en) * | 2004-04-29 | 2007-06-06 | i科学外科公司 | Apparatus and method for surgical enhancement of aqueous humor drainage |
US20100173866A1 (en) * | 2004-04-29 | 2010-07-08 | Iscience Interventional Corporation | Apparatus and method for ocular treatment |
CN101052434A (en) * | 2004-04-29 | 2007-10-10 | I科学干预公司 | Apparatus and method for ocular treatment |
US20050244471A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Estradiol derivative and estratopone containing sustained release intraocular implants and related methods |
US8119154B2 (en) * | 2004-04-30 | 2012-02-21 | Allergan, Inc. | Sustained release intraocular implants and related methods |
US20050267520A1 (en) * | 2004-05-12 | 2005-12-01 | Modesitt D B | Access and closure device and method |
US20060024350A1 (en) * | 2004-06-24 | 2006-02-02 | Varner Signe E | Biodegradable ocular devices, methods and systems |
EP3470108A1 (en) * | 2004-07-02 | 2019-04-17 | Mati Therapeutics Inc. | Treatment medium delivery device for delivery of treatment media to the eye |
US20060110428A1 (en) * | 2004-07-02 | 2006-05-25 | Eugene Dejuan | Methods and devices for the treatment of ocular conditions |
US7678133B2 (en) | 2004-07-10 | 2010-03-16 | Arstasis, Inc. | Biological tissue closure device and method |
US7117870B2 (en) * | 2004-07-26 | 2006-10-10 | Clarity Corporation | Lacrimal insert having reservoir with controlled release of medication and method of manufacturing the same |
US9138228B2 (en) | 2004-08-11 | 2015-09-22 | Emory University | Vascular conduit device and system for implanting |
US20060034891A1 (en) * | 2004-08-12 | 2006-02-16 | Laurie Lawin | Biodegradable controlled release bioactive agent delivery device |
US8246569B1 (en) | 2004-08-17 | 2012-08-21 | California Institute Of Technology | Implantable intraocular pressure drain |
US20060110429A1 (en) * | 2004-11-24 | 2006-05-25 | Therakine Corporation | Implant for intraocular drug delivery |
WO2006063021A2 (en) * | 2004-12-07 | 2006-06-15 | Surmodics, Inc. | Coatngs with crystallized active agents (s) |
WO2006068898A1 (en) * | 2004-12-22 | 2006-06-29 | Bausch & Lomb Incorporated | Reusable drug delivery device |
US20060147491A1 (en) * | 2005-01-05 | 2006-07-06 | Dewitt David M | Biodegradable coating compositions including multiple layers |
US20060198868A1 (en) * | 2005-01-05 | 2006-09-07 | Dewitt David M | Biodegradable coating compositions comprising blends |
AU2006210847A1 (en) * | 2005-02-01 | 2006-08-10 | Osteobiologics, Inc. | Method and device for selective addition of a bioactive agent to a multi-phase implant |
US8663639B2 (en) * | 2005-02-09 | 2014-03-04 | Santen Pharmaceutical Co., Ltd. | Formulations for treating ocular diseases and conditions |
EP1853259A1 (en) | 2005-02-09 | 2007-11-14 | Macusight, Inc. | Formulations for ocular treatment |
US20060233858A1 (en) * | 2005-03-08 | 2006-10-19 | Allergan, Inc. | Systems and methods providing targeted intraocular drug delivery |
US20070077270A1 (en) * | 2005-03-28 | 2007-04-05 | Clemson University | Delivery devices and methods for long-term, targeted delivery of therapeutic agents to the eye and ear |
EP1868661A1 (en) * | 2005-04-08 | 2007-12-26 | SurModics, Inc. | Sustained release implants for subretinal delivery |
US20060259008A1 (en) * | 2005-04-27 | 2006-11-16 | Allergan, Inc. | Apparatus and methods useful for intravitreal injection of drugs |
AU2006247355B2 (en) * | 2005-05-12 | 2013-01-10 | Arstasis, Inc. | Access and closure device and method |
US20060258994A1 (en) * | 2005-05-12 | 2006-11-16 | Avery Robert L | Implantable delivery device for administering pharmacological agents to an internal portion of a body |
WO2006125106A1 (en) * | 2005-05-18 | 2006-11-23 | Surmodics, Inc. | Insertion instrument for non-linear medical devices |
US20080207499A1 (en) * | 2005-06-29 | 2008-08-28 | Gaetano Barile | Rage-related methods for treating and preventing diabetic retinopathy |
US8109913B2 (en) * | 2005-07-11 | 2012-02-07 | Dsm Ip Assets B.V. | Coiled wire for the controlled release of drugs to the eye |
US8663673B2 (en) | 2005-07-29 | 2014-03-04 | Surmodics, Inc. | Devices, articles, coatings, and methods for controlled active agent release or hemocompatibility |
US20070060887A1 (en) * | 2005-08-22 | 2007-03-15 | Marsh David A | Ophthalmic injector |
US20070212397A1 (en) * | 2005-09-15 | 2007-09-13 | Roth Daniel B | Pharmaceutical delivery device and method for providing ocular treatment |
US20070071792A1 (en) * | 2005-09-21 | 2007-03-29 | Varner Signe E | In VIVO formed matrices including natural biodegradale polysaccharides and ophthalmic uses thereof |
CA2621595A1 (en) | 2005-09-21 | 2007-04-12 | Surmodics, Inc. | Coatings and articles including natural biodegradable polysaccharides |
US20080167600A1 (en) * | 2005-09-26 | 2008-07-10 | Peyman Gholam A | Device for delivery of an agent to the eye and other sites |
EP2218442A1 (en) | 2005-11-09 | 2010-08-18 | CombinatoRx, Inc. | Methods, compositions, and kits for the treatment of ophthalmic disorders |
CA2629648A1 (en) * | 2005-11-15 | 2007-05-24 | Neovista Inc. | Methods and apparatus for intraocular brachytherapy |
US8166909B2 (en) * | 2005-11-15 | 2012-05-01 | Surmodics, Inc. | Apparatus and methods for applying coatings |
MX2008006379A (en) | 2005-11-29 | 2009-03-03 | Smithkline Beecham Corp | Treatment method. |
JP5819579B2 (en) * | 2006-01-13 | 2015-11-24 | サーモディクス,インコーポレイティド | Microparticles containing matrices for drug delivery |
GB0600903D0 (en) * | 2006-01-17 | 2006-02-22 | Cancer Rec Tech Ltd | Treatment of cancer |
US9084662B2 (en) * | 2006-01-17 | 2015-07-21 | Transcend Medical, Inc. | Drug delivery treatment device |
ES2551782T3 (en) | 2006-01-17 | 2015-11-23 | Transcend Medical, Inc. | Device for the treatment of glaucoma |
ES2363938T3 (en) * | 2006-01-17 | 2011-08-19 | Nulens Ltd | INTRAOCULAR DRUG DISPENSER. |
WO2007092620A2 (en) | 2006-02-09 | 2007-08-16 | Macusight, Inc. | Stable formulations, and methods of their preparation and use |
WO2007106557A2 (en) * | 2006-03-14 | 2007-09-20 | University Of Southern California | Mems device for delivery of therapeutic agents |
AU2007230964B2 (en) | 2006-03-23 | 2012-07-19 | Santen Pharmaceutical Co., Ltd. | Formulations and methods for vascular permeability-related diseases or conditions |
US8676293B2 (en) * | 2006-04-13 | 2014-03-18 | Aecc Enterprises Ltd. | Devices, systems and methods for measuring and evaluating the motion and function of joint structures and associated muscles, determining suitability for orthopedic intervention, and evaluating efficacy of orthopedic intervention |
US7981096B2 (en) * | 2006-05-12 | 2011-07-19 | David Castillejos | Optic nerve head implant and medication delivery system |
US7811252B2 (en) * | 2006-05-17 | 2010-10-12 | Alcon Research, Ltd. | Dosage control device |
US7887521B2 (en) * | 2006-05-17 | 2011-02-15 | Alcon Research, Ltd. | Ophthalmic injection system |
US7862540B2 (en) * | 2006-05-17 | 2011-01-04 | Alcon Research, Ltd. | Ophthalmic injection device using shape memory alloy |
US20070268340A1 (en) * | 2006-05-17 | 2007-11-22 | Bruno Dacquay | Ophthalmic Injection System and Method Using Piezoelectric Array |
US7871399B2 (en) * | 2006-05-17 | 2011-01-18 | Alcon Research, Ltd. | Disposable ophthalmic injection device |
US20070270750A1 (en) * | 2006-05-17 | 2007-11-22 | Alcon, Inc. | Drug delivery device |
US7674243B2 (en) * | 2006-05-17 | 2010-03-09 | Alcon Inc. | Ophthalmic injection device using piezoelectric array |
US8668676B2 (en) * | 2006-06-19 | 2014-03-11 | Allergan, Inc. | Apparatus and methods for implanting particulate ocular implants |
US20070293873A1 (en) * | 2006-06-19 | 2007-12-20 | Allergan, Inc. | Apparatus and methods for implanting particulate ocular implants |
EP2037977A2 (en) * | 2006-06-28 | 2009-03-25 | SurModics, Inc. | Active agent eluting matrices with particulates |
US8968782B2 (en) * | 2006-06-28 | 2015-03-03 | Surmodics, Inc. | Combination degradable and non-degradable matrices for active agent delivery |
US8911496B2 (en) | 2006-07-11 | 2014-12-16 | Refocus Group, Inc. | Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods |
US20080097335A1 (en) * | 2006-08-04 | 2008-04-24 | Allergan, Inc. | Ocular implant delivery assemblies |
WO2008022258A2 (en) * | 2006-08-16 | 2008-02-21 | Surmodics, Inc. | Methods and materials for increasing the adhesion of elution control matrices to substrates |
US20080057106A1 (en) * | 2006-08-29 | 2008-03-06 | Erickson Signe R | Low profile bioactive agent delivery device |
US20080075753A1 (en) * | 2006-09-25 | 2008-03-27 | Chappa Ralph A | Multi-layered coatings and methods for controlling elution of active agents |
US20080097379A1 (en) * | 2006-09-26 | 2008-04-24 | Alcon Manufacturing, Ltd. | Ophthalmic injection method |
US20080125712A1 (en) * | 2006-09-26 | 2008-05-29 | Alcon Manufacturing, Ltd. | Ophthalmic injection system |
US20080075779A1 (en) * | 2006-09-27 | 2008-03-27 | Chappa Ralph A | Additives And Methods For Enhancing Active Agent Elution Kinetics |
US20080097390A1 (en) * | 2006-09-27 | 2008-04-24 | Alcon Manufacturing, Ltd. | Spring actuated delivery system |
WO2008060359A2 (en) * | 2006-09-29 | 2008-05-22 | Surmodics, Inc. | Biodegradable ocular implants and methods for treating ocular conditions |
WO2008108887A2 (en) * | 2006-10-16 | 2008-09-12 | Alcon Research, Ltd. | Method of operating ophthalmic hand piece with disposable end |
US20080281292A1 (en) * | 2006-10-16 | 2008-11-13 | Hickingbotham Dyson W | Retractable Injection Port |
ATE490752T1 (en) * | 2006-10-16 | 2010-12-15 | Alcon Res Ltd | UNIVERSAL RECHARGEABLE ASSEMBLY WITH LIMITED REUSABILITY FOR AN OPHTHALMIC HANDPIECE |
US9022970B2 (en) * | 2006-10-16 | 2015-05-05 | Alcon Research, Ltd. | Ophthalmic injection device including dosage control device |
US7831309B1 (en) | 2006-12-06 | 2010-11-09 | University Of Southern California | Implants based on bipolar metal oxide semiconductor (MOS) electronics |
US20080147021A1 (en) * | 2006-12-15 | 2008-06-19 | Jani Dharmendra M | Drug delivery devices |
US20090005869A1 (en) * | 2006-12-15 | 2009-01-01 | University Of Virginia Patent Foundation | Device which Attaches into a Joint and Carries a Payload of Controlled Release Drugs and Related Method thereof |
ZA200903649B (en) * | 2006-12-18 | 2010-08-25 | Alcon Res Ltd | Devices and methods for ophthalmic drug delivery |
US7846123B2 (en) | 2007-04-24 | 2010-12-07 | Emory University | Conduit device and system for implanting a conduit device in a tissue wall |
US20080265343A1 (en) * | 2007-04-26 | 2008-10-30 | International Business Machines Corporation | Field effect transistor with inverted t shaped gate electrode and methods for fabrication thereof |
US9125807B2 (en) * | 2007-07-09 | 2015-09-08 | Incept Llc | Adhesive hydrogels for ophthalmic drug delivery |
EP2173289A4 (en) | 2007-07-17 | 2010-11-24 | Transcend Medical Inc | Ocular implant with hydrogel expansion capabilities |
US7740619B2 (en) | 2007-08-01 | 2010-06-22 | Alcon Research, Ltd. | Spring driven ophthalmic injection device with safety actuator lockout feature |
US20090036842A1 (en) * | 2007-08-03 | 2009-02-05 | Raffi Pinedjian | Consumable Activation Lever For Injection Device |
US20090099481A1 (en) * | 2007-10-10 | 2009-04-16 | Adam Deitz | Devices, Systems and Methods for Measuring and Evaluating the Motion and Function of Joints and Associated Muscles |
US20090105744A1 (en) * | 2007-10-17 | 2009-04-23 | Modesitt D Bruce | Methods for forming tracts in tissue |
US9849027B2 (en) | 2007-11-08 | 2017-12-26 | Alimera Sciences, Inc. | Ocular implantation device |
EP2242464B2 (en) | 2007-12-20 | 2017-03-01 | University Of Southern California | Apparatus for delivering therapeutic agents |
US20090192493A1 (en) * | 2008-01-03 | 2009-07-30 | University Of Southern California | Implantable drug-delivery devices, and apparatus and methods for refilling the devices |
US9056201B1 (en) | 2008-01-07 | 2015-06-16 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive delivery of radiation to the eye |
US10022558B1 (en) | 2008-01-07 | 2018-07-17 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive delivery of radiation to the eye |
DK2227257T3 (en) * | 2008-01-07 | 2013-09-30 | Salutaris Medical Devices Inc | DEVICES FOR MINIMUM-INVASIVE EXTRAOCULAR RADIATION TO THE POSTERIOR PART OF THE EYE |
US8608632B1 (en) | 2009-07-03 | 2013-12-17 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive extraocular delivery of radiation and/or pharmaceutics to the posterior portion of the eye |
US8602959B1 (en) | 2010-05-21 | 2013-12-10 | Robert Park | Methods and devices for delivery of radiation to the posterior portion of the eye |
US9873001B2 (en) | 2008-01-07 | 2018-01-23 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive delivery of radiation to the eye |
US20090186059A1 (en) * | 2008-01-14 | 2009-07-23 | Johnson Elizabeth E | Devices and methods for elution of nucleic acid delivery complexes |
WO2009097468A2 (en) | 2008-01-29 | 2009-08-06 | Kliman Gilbert H | Drug delivery devices, kits and methods therefor |
US20100152646A1 (en) * | 2008-02-29 | 2010-06-17 | Reshma Girijavallabhan | Intravitreal injection device and method |
US20090227938A1 (en) * | 2008-03-05 | 2009-09-10 | Insitu Therapeutics, Inc. | Wound Closure Devices, Methods of Use, and Kits |
US20090263449A1 (en) * | 2008-04-09 | 2009-10-22 | Surmodics, Inc. | Delivery of nucleic acid complexes from materials including negatively charged groups |
EP2265293B1 (en) * | 2008-04-18 | 2015-11-04 | SurModics, Inc. | Coating systems for the controlled delivery of hydrophilic bioactive agents |
JP5763525B2 (en) * | 2008-05-07 | 2015-08-12 | サーモディクス,インコーポレイティド | Delivery of nucleic acid complexes from particles |
CA2723724C (en) | 2008-05-08 | 2017-03-14 | Replenish Pumps, Llc | Implantable pumps and cannulas therefor |
CN102202708B (en) | 2008-05-08 | 2015-01-21 | 迷你泵有限责任公司 | Drug-delivery pumps and methods of manufacture |
US9849238B2 (en) | 2008-05-08 | 2017-12-26 | Minipumps, Llc | Drug-delivery pump with intelligent control |
CA2723723C (en) | 2008-05-08 | 2019-06-25 | Replenish Pumps, Llc | Implantable drug-delivery devices, and apparatus and methods for filling the devices |
EP2296756A1 (en) | 2008-06-04 | 2011-03-23 | Neovista, Inc. | Handheld radiation delivery system for advancing a radiation source wire |
ES2640867T3 (en) | 2008-06-25 | 2017-11-07 | Novartis Ag | Eye implant with ability to change shape |
AU2009274128A1 (en) * | 2008-07-21 | 2010-01-28 | Arstasis, Inc. | Devices and methods for forming tracts in tissue |
CN102159126A (en) * | 2008-07-21 | 2011-08-17 | 阿尔斯塔西斯公司 | Devices, methods, and kits for forming tracts in tissue |
US8459310B2 (en) * | 2008-07-24 | 2013-06-11 | Surmodics, Inc. | Systems and methods for filling medical device lumen |
WO2010062394A2 (en) | 2008-11-26 | 2010-06-03 | Surmodics, Inc. | Implantable ocular drug delivery device and methods |
CA2747556A1 (en) * | 2008-12-19 | 2010-06-24 | Qlt Inc. | Substance delivering punctum implants and methods |
CN102271632A (en) | 2009-01-02 | 2011-12-07 | 爱尔康研究有限公司 | In-situ refillable ophthalmic implant |
USD691267S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to eye |
USD691269S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to an eye |
USD691268S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to eye |
USD691270S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to an eye |
US8545554B2 (en) * | 2009-01-16 | 2013-10-01 | Allergan, Inc. | Intraocular injector |
US8425473B2 (en) | 2009-01-23 | 2013-04-23 | Iscience Interventional Corporation | Subretinal access device |
US20100191177A1 (en) * | 2009-01-23 | 2010-07-29 | Iscience Interventional Corporation | Device for aspirating fluids |
JP5524983B2 (en) | 2009-01-28 | 2014-06-18 | トランセンド・メディカル・インコーポレイテッド | Implant system |
US20100191168A1 (en) | 2009-01-29 | 2010-07-29 | Trustees Of Tufts College | Endovascular cerebrospinal fluid shunt |
SG173167A1 (en) * | 2009-01-29 | 2011-08-29 | Forsight Labs Llc | Posterior segment drug delivery |
US8623395B2 (en) | 2010-01-29 | 2014-01-07 | Forsight Vision4, Inc. | Implantable therapeutic device |
EP2396070A4 (en) | 2009-02-12 | 2012-09-19 | Incept Llc | Drug delivery through hydrogel plugs |
US8911495B2 (en) | 2009-03-16 | 2014-12-16 | Endoshape, Inc. | Reliably retained shape memory ophthalmological implants |
US8372036B2 (en) | 2009-05-06 | 2013-02-12 | Alcon Research, Ltd. | Multi-layer heat assembly for a drug delivery device |
AU2010248821A1 (en) * | 2009-05-15 | 2011-12-01 | Arstasis, Inc. | Devices, methods and kits for forming tracts in tissue |
CA2763522A1 (en) | 2009-06-02 | 2010-12-09 | Surmodics, Inc. | Silane-functionalized hydrophobic .alpha.(1.fwdarw.-4)glucopyranose polymers and polymeric matrices for implantation or injection |
CN102596097B (en) | 2009-06-03 | 2015-05-20 | 弗赛特实验室有限责任公司 | Anterior segment drug delivery |
CA2769030C (en) | 2009-07-30 | 2016-05-10 | Tandem Diabetes Care, Inc. | Infusion pump system with disposable cartridge having pressure venting and pressure feedback |
KR101697388B1 (en) | 2009-08-18 | 2017-01-17 | 미니펌프스, 엘엘씨 | Electrolytic drug-delivery pump with adaptive control |
US20110054445A1 (en) * | 2009-09-02 | 2011-03-03 | Board Of Regents, The University Of Texas System | Devices and Methods for Treatment of Eye Disease |
US8545431B2 (en) * | 2009-09-21 | 2013-10-01 | Alcon Research, Ltd. | Lumen clearing valve for glaucoma drainage device |
US8257295B2 (en) | 2009-09-21 | 2012-09-04 | Alcon Research, Ltd. | Intraocular pressure sensor with external pressure compensation |
US8419673B2 (en) | 2009-09-21 | 2013-04-16 | Alcon Research, Ltd. | Glaucoma drainage device with pump |
US8721580B2 (en) * | 2009-09-21 | 2014-05-13 | Alcon Research, Ltd. | Power saving glaucoma drainage device |
CA2774958A1 (en) * | 2009-09-22 | 2011-03-31 | Arstasis, Inc. | Devices, methods, and kits for forming tracts in tissue |
WO2011038236A2 (en) | 2009-09-25 | 2011-03-31 | Ortho Kinematics, Inc. | Systems and devices for an integrated imaging system with real-time feedback loops and methods therefor |
US20110166555A1 (en) * | 2009-09-30 | 2011-07-07 | Jianbo Zhou | Carrier for an insertable medical device, insertion tools, methods of use, and kits |
EP2482863A1 (en) | 2009-09-30 | 2012-08-08 | SurModics, Inc. | Hydrophobic polysaccharides with silyl ether linkages having enhanced degradation and medical articles made therefrom |
US20120232102A1 (en) | 2009-09-30 | 2012-09-13 | Chun-Fang Xu | Methods Of Administration And Treatment |
EP2496304A4 (en) * | 2009-11-02 | 2013-04-17 | Salutaris Medical Devices Inc | Methods and devices for delivering appropriate minimally-invasive extraocular radiation |
US20110105990A1 (en) * | 2009-11-04 | 2011-05-05 | Silvestrini Thomas A | Zonal drug delivery device and method |
US8177747B2 (en) | 2009-12-22 | 2012-05-15 | Alcon Research, Ltd. | Method and apparatus for drug delivery |
US8529492B2 (en) * | 2009-12-23 | 2013-09-10 | Trascend Medical, Inc. | Drug delivery devices and methods |
US20110159098A1 (en) * | 2009-12-30 | 2011-06-30 | Surmodics, Inc. | Stabilization and delivery of nucleic acid complexes |
US20110184310A1 (en) * | 2010-01-27 | 2011-07-28 | Joe Denton Brown | Method of heating a shape memory alloy of a surgical instrument |
US10413506B2 (en) | 2010-04-03 | 2019-09-17 | Praful Doshi | Medical devices including medicaments and methods of making and using same including enhancing comfort, enhancing drug penetration, and treatment of myopia |
CA2794956C (en) | 2010-04-03 | 2017-05-02 | Praful Doshi | Medical devices including medicaments and methods of making and using same |
MX340696B (en) | 2010-04-30 | 2016-07-21 | Alexion Pharma Inc | Anti-c5a antibodies and methods for using the antibodies. |
HUE054113T2 (en) | 2010-08-05 | 2021-08-30 | Forsight Vision4 Inc | Injector apparatus for drug delivery |
EP2600812B1 (en) | 2010-08-05 | 2021-09-22 | ForSight Vision4, Inc. | Apparatus to treat an eye |
CA2807537C (en) * | 2010-08-05 | 2018-09-18 | Forsight Vision4, Inc. | Combined drug delivery methods and apparatus |
US8961501B2 (en) | 2010-09-17 | 2015-02-24 | Incept, Llc | Method for applying flowable hydrogels to a cornea |
WO2012058274A2 (en) | 2010-10-26 | 2012-05-03 | Surmodics, Inc. | Coatings and methods for controlled elution of hydrophilic active agents |
WO2012065006A2 (en) | 2010-11-11 | 2012-05-18 | Forsight Vision4, Inc. | Methods and apparatus to determine porous structures for drug delivery |
CA2818612C (en) | 2010-11-19 | 2020-12-29 | Forsight Vision4, Inc. | Therapeutic agent formulations for implanted devices |
US8901092B2 (en) | 2010-12-29 | 2014-12-02 | Surmodics, Inc. | Functionalized polysaccharides for active agent delivery |
EP2667792B1 (en) | 2011-01-28 | 2020-05-06 | Apica Cardiovascular Limited | Systems for sealing a tissue wall puncture |
AU2012212215B2 (en) | 2011-02-01 | 2015-07-30 | Emory University | Systems for implanting and using a conduit within a tissue wall |
US10286146B2 (en) | 2011-03-14 | 2019-05-14 | Minipumps, Llc | Implantable drug pumps and refill devices therefor |
US9919099B2 (en) | 2011-03-14 | 2018-03-20 | Minipumps, Llc | Implantable drug pumps and refill devices therefor |
US9603997B2 (en) | 2011-03-14 | 2017-03-28 | Minipumps, Llc | Implantable drug pumps and refill devices therefor |
US8992503B2 (en) | 2011-03-27 | 2015-03-31 | Microsert Ltd. | Miniature implanted drug delivery devices and inserter systems for introducing such devices |
EP4249059A3 (en) | 2011-06-28 | 2023-11-29 | ForSight Vision4, Inc. | An apparatus for collecting a sample of fluid from a reservoir chamber of a therapeutic device for the eye |
EP2739252A4 (en) | 2011-08-05 | 2015-08-12 | Forsight Vision4 Inc | Small molecule delivery with implantable therapeutic device |
WO2013027107A1 (en) * | 2011-08-23 | 2013-02-28 | Simcha Milo | Device for creating temporary access and then closure |
CN106073986B (en) | 2011-09-14 | 2019-01-11 | 弗赛特影像5股份有限公司 | The device for treating the eyes of patient |
CN103796573A (en) * | 2011-09-15 | 2014-05-14 | 优瑟夫·雅阿科比 | Systems and methods for treating ear disorders |
PL2755600T3 (en) | 2011-09-16 | 2021-09-20 | Forsight Vision4, Inc. | Fluid exchange apparatus |
US10226417B2 (en) | 2011-09-16 | 2019-03-12 | Peter Jarrett | Drug delivery systems and applications |
US8585631B2 (en) | 2011-10-18 | 2013-11-19 | Alcon Research, Ltd. | Active bimodal valve system for real-time IOP control |
US8840578B2 (en) | 2011-12-09 | 2014-09-23 | Alcon Research, Ltd. | Multilayer membrane actuators |
US8579848B2 (en) | 2011-12-09 | 2013-11-12 | Alcon Research, Ltd. | Active drainage systems with pressure-driven valves and electronically-driven pump |
US9622910B2 (en) | 2011-12-12 | 2017-04-18 | Alcon Research, Ltd. | Active drainage systems with dual-input pressure-driven values |
US9125721B2 (en) | 2011-12-13 | 2015-09-08 | Alcon Research, Ltd. | Active drainage systems with dual-input pressure-driven valves |
US9339187B2 (en) | 2011-12-15 | 2016-05-17 | Alcon Research, Ltd. | External pressure measurement system and method for an intraocular implant |
US9241829B2 (en) | 2011-12-20 | 2016-01-26 | Abbott Medical Optics Inc. | Implantable intraocular drug delivery apparatus, system and method |
US10010448B2 (en) | 2012-02-03 | 2018-07-03 | Forsight Vision4, Inc. | Insertion and removal methods and apparatus for therapeutic devices |
US10085633B2 (en) | 2012-04-19 | 2018-10-02 | Novartis Ag | Direct visualization system for glaucoma treatment |
US9241832B2 (en) | 2012-04-24 | 2016-01-26 | Transcend Medical, Inc. | Delivery system for ocular implant |
US9180242B2 (en) | 2012-05-17 | 2015-11-10 | Tandem Diabetes Care, Inc. | Methods and devices for multiple fluid transfer |
RU2014152803A (en) | 2012-05-25 | 2016-07-20 | Новартис Аг | WATER PHARMACEUTICAL COMPOSITION CONTAINING A THERAPEUTIC AGENT AND GUANIDINE, GUANIDINE DERIVATIVE AND INJECTION INCLUDING THIS COMPOSITION |
US20130317481A1 (en) | 2012-05-25 | 2013-11-28 | Arstasis, Inc. | Vascular access configuration |
US20130317438A1 (en) | 2012-05-25 | 2013-11-28 | Arstasis, Inc. | Vascular access configuration |
JP6549482B2 (en) | 2012-06-01 | 2019-07-24 | サーモディクス,インコーポレイテッド | Device and method for coating a balloon catheter |
US9827401B2 (en) | 2012-06-01 | 2017-11-28 | Surmodics, Inc. | Apparatus and methods for coating medical devices |
US9480598B2 (en) | 2012-09-17 | 2016-11-01 | Novartis Ag | Expanding ocular implant devices and methods |
US11090468B2 (en) | 2012-10-25 | 2021-08-17 | Surmodics, Inc. | Apparatus and methods for coating medical devices |
US9750636B2 (en) | 2012-10-26 | 2017-09-05 | Forsight Vision5, Inc. | Ophthalmic system for sustained release of drug to eye |
WO2014078288A1 (en) | 2012-11-14 | 2014-05-22 | Transcend Medical, Inc. | Flow promoting ocular implant |
US9295389B2 (en) | 2012-12-17 | 2016-03-29 | Novartis Ag | Systems and methods for priming an intraocular pressure sensor in an intraocular implant |
US9528633B2 (en) | 2012-12-17 | 2016-12-27 | Novartis Ag | MEMS check valve |
US9572712B2 (en) | 2012-12-17 | 2017-02-21 | Novartis Ag | Osmotically actuated fluidic valve |
EP2948104B1 (en) | 2013-01-25 | 2019-07-24 | Apica Cardiovascular Limited | Systems for percutaneous access, stabilization and closure of organs |
US9968603B2 (en) | 2013-03-14 | 2018-05-15 | Forsight Vision4, Inc. | Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant |
US9173998B2 (en) | 2013-03-14 | 2015-11-03 | Tandem Diabetes Care, Inc. | System and method for detecting occlusions in an infusion pump |
EP2968717A4 (en) | 2013-03-15 | 2017-02-22 | Apk Advanced Medical Technologies, Inc. | Devices, systems, and methods for implanting and using a connnector in a tissue wall |
JP6444973B2 (en) | 2013-03-15 | 2018-12-26 | オプティメディカ・コーポレイションOptimedica Corporation | Microfemto incision method and system |
JP6385423B2 (en) | 2013-03-28 | 2018-09-05 | フォーサイト・ビジョン フォー・インコーポレーテッド | Ocular graft for therapeutic substance delivery |
US9987163B2 (en) | 2013-04-16 | 2018-06-05 | Novartis Ag | Device for dispensing intraocular substances |
EP3019243A4 (en) | 2013-07-12 | 2017-03-15 | Ophthotech Corporation | Methods for treating or preventing ophthalmological conditions |
US9226851B2 (en) | 2013-08-24 | 2016-01-05 | Novartis Ag | MEMS check valve chip and methods |
US9289324B2 (en) | 2013-08-26 | 2016-03-22 | Novartis Ag | Externally adjustable passive drainage device |
US9283115B2 (en) | 2013-08-26 | 2016-03-15 | Novartis Ag | Passive to active staged drainage device |
US11219552B2 (en) | 2013-09-06 | 2022-01-11 | The Regents Of The University Of Colorado, A Body Corporate | Intraocular filter device and methods of using same |
US10518002B2 (en) | 2013-09-06 | 2019-12-31 | The Regents Of The University Of Colorado, A Body Corporate | Intraocular drug delivery and filter device and methods of using same |
US9737696B2 (en) | 2014-01-15 | 2017-08-22 | Tufts Medical Center, Inc. | Endovascular cerebrospinal fluid shunt |
EP3094365B1 (en) | 2014-01-15 | 2021-12-08 | Tufts Medical Center, Inc. | Endovascular cerebrospinal fluid shunt |
NZ711451A (en) | 2014-03-07 | 2016-05-27 | Alexion Pharma Inc | Anti-c5 antibodies having improved pharmacokinetics |
US9681983B2 (en) | 2014-03-13 | 2017-06-20 | Novartis Ag | Debris clearance system for an ocular implant |
US9603742B2 (en) | 2014-03-13 | 2017-03-28 | Novartis Ag | Remote magnetic driven flow system |
USD760381S1 (en) | 2014-06-25 | 2016-06-28 | Donald Fox | Orbital injection cannula |
JP6581194B2 (en) | 2014-07-15 | 2019-09-25 | フォーサイト・ビジョン フォー・インコーポレーテッドForsight Vision4, Inc. | Ocular implant delivery device and method |
CN107106551A (en) | 2014-08-08 | 2017-08-29 | 弗赛特影像4股份有限公司 | The stabilization of receptor tyrosine kinase inhibitors and solvable preparation and its preparation method |
WO2016070025A1 (en) | 2014-10-31 | 2016-05-06 | Thoratec Corporation | Apical connectors and instruments for use in a heart wall |
WO2016070147A1 (en) | 2014-10-31 | 2016-05-06 | Cerevasc, Llc | Methods and systems for treating hydrocephalus |
SG11201703726XA (en) * | 2014-11-10 | 2017-06-29 | Forsight Vision4 Inc | Expandable drug delivery devices and method of use |
US9655777B2 (en) | 2015-04-07 | 2017-05-23 | Novartis Ag | System and method for diagphragm pumping using heating element |
EP3283004A4 (en) | 2015-04-13 | 2018-12-05 | Forsight Vision5, Inc. | Ocular insert composition of semi-crystalline or crystalline pharmaceutically active agent |
US20160354161A1 (en) | 2015-06-05 | 2016-12-08 | Ortho Kinematics, Inc. | Methods for data processing for intra-operative navigation systems |
US10182939B2 (en) | 2015-09-16 | 2019-01-22 | Novartis Ag | Hydraulic injector and methods for intra-ocular lens insertion |
JP6820612B2 (en) | 2015-10-30 | 2021-01-27 | セレバスク,インコーポレイテッド | Hydrocephalus treatment system and method |
CN113069681B (en) | 2015-11-20 | 2022-12-23 | 弗赛特影像4股份有限公司 | Method of manufacturing a therapeutic device for sustained drug delivery |
US10420724B2 (en) | 2015-11-25 | 2019-09-24 | Incept, Llc | Shape changing drug delivery devices and methods |
CA3019822A1 (en) | 2016-04-05 | 2017-10-12 | Forsight Vision4, Inc. | Implantable ocular drug delivery devices |
USD815285S1 (en) | 2016-05-11 | 2018-04-10 | Salutaris Medical Devices, Inc. | Brachytherapy device |
USD814637S1 (en) | 2016-05-11 | 2018-04-03 | Salutaris Medical Devices, Inc. | Brachytherapy device |
USD814638S1 (en) | 2016-05-11 | 2018-04-03 | Salutaris Medical Devices, Inc. | Brachytherapy device |
USD808529S1 (en) | 2016-08-31 | 2018-01-23 | Salutaris Medical Devices, Inc. | Holder for a brachytherapy device |
USD808528S1 (en) | 2016-08-31 | 2018-01-23 | Salutaris Medical Devices, Inc. | Holder for a brachytherapy device |
KR20200027971A (en) | 2017-07-14 | 2020-03-13 | 싸이톰스 테라퓨틱스, 인크. | Anti-CD166 antibodies and uses thereof |
CN116271012A (en) | 2017-07-27 | 2023-06-23 | 瑞颂医药公司 | High concentration anti-C5 antibody formulations |
CN107519532B (en) * | 2017-08-25 | 2020-10-02 | 唐山市工人医院 | Elastic prosthesis material and preparation method thereof |
WO2019103906A1 (en) | 2017-11-21 | 2019-05-31 | Forsight Vision4, Inc. | Fluid exchange apparatus for expandable port delivery system and methods of use |
EP3501433A1 (en) * | 2017-12-21 | 2019-06-26 | Universiteit Maastricht | Apparatus for handling a rod shaped element to be inserted into or removed from the eye of a patient |
US11013900B2 (en) | 2018-03-08 | 2021-05-25 | CereVasc, Inc. | Systems and methods for minimally invasive drug delivery to a subarachnoid space |
CN111989068A (en) | 2018-05-24 | 2020-11-24 | 塞拉尼斯伊娃高性能聚合物公司 | Implantable devices for sustained release of macromolecular drug compounds |
US11690807B2 (en) | 2018-05-24 | 2023-07-04 | Celanese Eva Performance Polymers Llc | Implantable device for sustained release of a macromolecular drug compound |
US20200100941A1 (en) * | 2018-08-25 | 2020-04-02 | Thad Anthony Labbe | Ophthalmic surgical instruments for removal of lens materials and methods of use |
WO2020112816A1 (en) | 2018-11-29 | 2020-06-04 | Surmodics, Inc. | Apparatus and methods for coating medical devices |
US11793834B2 (en) | 2018-12-12 | 2023-10-24 | Kite Pharma, Inc. | Chimeric antigen and T cell receptors and methods of use |
CN109431678B (en) * | 2018-12-17 | 2021-05-28 | 中国医学科学院北京协和医院 | Transscleral drug delivery system |
US11819590B2 (en) | 2019-05-13 | 2023-11-21 | Surmodics, Inc. | Apparatus and methods for coating medical devices |
CN115605229A (en) | 2020-04-24 | 2023-01-13 | 米伦纽姆医药公司(Us) | anti-CD 19 antibodies and uses thereof |
EP4281144A1 (en) | 2021-01-22 | 2023-11-29 | Shifamed Holdings, LLC | Adjustable shunting systems with plate assemblies, and associated systems and methods |
WO2022215054A1 (en) | 2021-04-09 | 2022-10-13 | Takeda Pharmaceutical Company Limited | Antibodies targeting complement factor d and uses therof |
IL307939A (en) | 2021-04-26 | 2023-12-01 | Millennium Pharm Inc | Anti-clec12a antibodies and uses thereof |
WO2022232035A1 (en) | 2021-04-26 | 2022-11-03 | Millennium Pharmaceuticals, Inc. | Anti-adgre2 antibodies and uses thereof |
TW202330612A (en) | 2021-10-20 | 2023-08-01 | 日商武田藥品工業股份有限公司 | Compositions targeting bcma and methods of use thereof |
Family Cites Families (90)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US273410A (en) | 1883-03-06 | Gelatine eye-disk | ||
US3416530A (en) | 1966-03-02 | 1968-12-17 | Richard A. Ness | Eyeball medication dispensing tablet |
US4069307A (en) | 1970-10-01 | 1978-01-17 | Alza Corporation | Drug-delivery device comprising certain polymeric materials for controlled release of drug |
US4144317A (en) | 1975-05-30 | 1979-03-13 | Alza Corporation | Device consisting of copolymer having acetoxy groups for delivering drugs |
US4014334A (en) * | 1976-02-02 | 1977-03-29 | Alza Corporation | Laminated osmotic system for dispensing beneficial agent |
US4206756A (en) * | 1977-03-23 | 1980-06-10 | Murray Grossan | Jet ear irrigation system |
US4300557A (en) | 1980-01-07 | 1981-11-17 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method for treating intraocular malignancies |
US4304765A (en) | 1980-10-14 | 1981-12-08 | Alza Corporation | Ocular insert housing steroid in two different therapeutic forms |
US4678466A (en) * | 1981-06-25 | 1987-07-07 | Rosenwald Peter L | Internal medication delivery method and vehicle |
US4451254A (en) * | 1982-03-15 | 1984-05-29 | Eli Lilly And Company | Implant system |
CA1232814A (en) | 1983-09-16 | 1988-02-16 | Hidetoshi Sakamoto | Guide wire for catheter |
US4764377A (en) | 1983-10-07 | 1988-08-16 | The Forsyth Dental Infirmary For Children | Intra-pocket drug delivery devices for treatment of periodontal diseases |
US4892736A (en) | 1983-10-07 | 1990-01-09 | The Forsyth Dental Infirmary For Children | Intra-pocket drug delivery devices for treatment of periodontal diseases |
US4701180A (en) * | 1986-02-19 | 1987-10-20 | Kelly L Thomas | Implanted anchor and insert with analog display |
US4665905A (en) | 1986-06-09 | 1987-05-19 | Brown Charles S | Dynamic elbow and knee extension brace |
US5989579A (en) | 1986-10-02 | 1999-11-23 | Escalon Medical Corp. | Ocular insert with anchoring protrusions |
US5322691A (en) * | 1986-10-02 | 1994-06-21 | Sohrab Darougar | Ocular insert with anchoring protrusions |
DE3853591T2 (en) | 1987-12-17 | 1995-09-14 | United States Surgical Corp | MEDICAL ARRANGEMENTS MADE FROM HOMOMOLES AND COPOLYMERS WITH RECURRING CARBONATE UNITS. |
US4853224A (en) | 1987-12-22 | 1989-08-01 | Visionex | Biodegradable ocular implants |
US4936825A (en) * | 1988-04-11 | 1990-06-26 | Ungerleider Bruce A | Method for reducing intraocular pressure caused by glaucoma |
US5098443A (en) | 1989-03-23 | 1992-03-24 | University Of Miami | Method of implanting intraocular and intraorbital implantable devices for the controlled release of pharmacological agents |
US5164188A (en) | 1989-11-22 | 1992-11-17 | Visionex, Inc. | Biodegradable ocular implants |
KR0185215B1 (en) | 1990-11-30 | 1999-05-01 | 요시다 쇼오지 | A controlled-release pharmaceutical preparation for intra-ocular implant |
US5378475A (en) | 1991-02-21 | 1995-01-03 | University Of Kentucky Research Foundation | Sustained release drug delivery devices |
US5364343A (en) * | 1991-03-06 | 1994-11-15 | D.D. S.R.L. | Irrigation device for use in ear canals for therapeutic or hygienic purposes |
US5246867A (en) | 1992-01-17 | 1993-09-21 | University Of Maryland At Baltimore | Determination and quantification of saccharides by luminescence lifetimes and energy transfer |
US5178635A (en) | 1992-05-04 | 1993-01-12 | Allergan, Inc. | Method for determining amount of medication in an implantable device |
US5578075B1 (en) | 1992-11-04 | 2000-02-08 | Daynke Res Inc | Minimally invasive bioactivated endoprosthesis for vessel repair |
US5464650A (en) | 1993-04-26 | 1995-11-07 | Medtronic, Inc. | Intravascular stent and method |
ATE154757T1 (en) | 1993-07-19 | 1997-07-15 | Angiotech Pharm Inc | ANTI-ANGIogenic AGENTS AND METHODS OF USE THEREOF |
US5716981A (en) | 1993-07-19 | 1998-02-10 | Angiogenesis Technologies, Inc. | Anti-angiogenic compositions and methods of use |
US5443505A (en) | 1993-11-15 | 1995-08-22 | Oculex Pharmaceuticals, Inc. | Biocompatible ocular implants |
US5466233A (en) | 1994-04-25 | 1995-11-14 | Escalon Ophthalmics, Inc. | Tack for intraocular drug delivery and method for inserting and removing same |
US5472436A (en) | 1994-07-26 | 1995-12-05 | Fremstad; Daria A. | Ocular appliance for delivering medication |
US5582616A (en) | 1994-08-05 | 1996-12-10 | Origin Medsystems, Inc. | Surgical helical fastener with applicator |
US5725493A (en) * | 1994-12-12 | 1998-03-10 | Avery; Robert Logan | Intravitreal medicine delivery |
US5551427A (en) * | 1995-02-13 | 1996-09-03 | Altman; Peter A. | Implantable device for the effective elimination of cardiac arrhythmogenic sites |
US5605696A (en) | 1995-03-30 | 1997-02-25 | Advanced Cardiovascular Systems, Inc. | Drug loaded polymeric material and method of manufacture |
US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
US6120536A (en) | 1995-04-19 | 2000-09-19 | Schneider (Usa) Inc. | Medical devices with long term non-thrombogenic coatings |
US5837313A (en) | 1995-04-19 | 1998-11-17 | Schneider (Usa) Inc | Drug release stent coating process |
IL113723A (en) * | 1995-05-14 | 2002-11-10 | Optonol Ltd | Intraocular implant |
US5773019A (en) | 1995-09-27 | 1998-06-30 | The University Of Kentucky Research Foundation | Implantable controlled release device to deliver drugs directly to an internal portion of the body |
US5904144A (en) | 1996-03-22 | 1999-05-18 | Cytotherapeutics, Inc. | Method for treating ophthalmic diseases |
ZA97976B (en) | 1996-04-05 | 1997-08-18 | Alza Corp | Uniform drug delivery theraphy. |
US5928662A (en) | 1996-07-31 | 1999-07-27 | Phillips; Andrew F. | Ocular drug delivery device |
ZA978537B (en) | 1996-09-23 | 1998-05-12 | Focal Inc | Polymerizable biodegradable polymers including carbonate or dioxanone linkages. |
US5997517A (en) | 1997-01-27 | 1999-12-07 | Sts Biopolymers, Inc. | Bonding layers for medical device surface coatings |
PT973499E (en) | 1997-03-31 | 2003-12-31 | Alza Corp | IMPLANTABLE DIFFUSER ADMINISTRATION SYSTEM |
US5879697A (en) | 1997-04-30 | 1999-03-09 | Schneider Usa Inc | Drug-releasing coatings for medical devices |
US6110483A (en) | 1997-06-23 | 2000-08-29 | Sts Biopolymers, Inc. | Adherent, flexible hydrogel and medicated coatings |
WO1999001114A1 (en) | 1997-07-02 | 1999-01-14 | Euro-Celtique, S.A. | Prolonged anesthesia in joints and body spaces |
EP1003569B1 (en) | 1997-08-11 | 2004-10-20 | Allergan, Inc. | Sterile bioerodible implant device containing retinoid with improved biocompatability and method of manufacture |
US6306166B1 (en) | 1997-08-13 | 2001-10-23 | Scimed Life Systems, Inc. | Loading and release of water-insoluble drugs |
US5972027A (en) * | 1997-09-30 | 1999-10-26 | Scimed Life Systems, Inc | Porous stent drug delivery system |
KR100289471B1 (en) | 1998-01-19 | 2001-09-17 | 김충섭 | A controlled/sustained implant delivery containing fentanyls |
US20020188037A1 (en) | 1999-04-15 | 2002-12-12 | Chudzik Stephen J. | Method and system for providing bioactive agent release coating |
ES2179646T3 (en) | 1998-04-27 | 2003-01-16 | Surmodics Inc | COATING THAT RELEASES A BIOACTIVE AGENT. |
US6013099A (en) | 1998-04-29 | 2000-01-11 | Medtronic, Inc. | Medical device for delivering a water-insoluble therapeutic salt or substance |
WO1999066978A1 (en) * | 1998-06-22 | 1999-12-29 | Neovasys, Inc. | Method, implant and delivery system for enhancing blood flow in tissue |
US6153252A (en) | 1998-06-30 | 2000-11-28 | Ethicon, Inc. | Process for coating stents |
CN1311684A (en) | 1998-07-10 | 2001-09-05 | 悉尼大学 | Propylactic treatments of neovascularisation in macular degeneration |
US6378526B1 (en) * | 1998-08-03 | 2002-04-30 | Insite Vision, Incorporated | Methods of ophthalmic administration |
US6399655B1 (en) | 1998-12-22 | 2002-06-04 | Johns Hopkins University, School Of Medicine | Method for the prophylactic treatment of cataracts |
US20040121014A1 (en) | 1999-03-22 | 2004-06-24 | Control Delivery Systems, Inc. | Method for treating and/or preventing retinal diseases with sustained release corticosteroids |
US6217895B1 (en) | 1999-03-22 | 2001-04-17 | Control Delivery Systems | Method for treating and/or preventing retinal diseases with sustained release corticosteroids |
US6309660B1 (en) | 1999-07-28 | 2001-10-30 | Edwards Lifesciences Corp. | Universal biocompatible coating platform for medical devices |
US6331313B1 (en) | 1999-10-22 | 2001-12-18 | Oculex Pharmaceticals, Inc. | Controlled-release biocompatible ocular drug delivery implant devices and methods |
US6264971B1 (en) | 1999-11-04 | 2001-07-24 | Btg International Limited | Ocular insert |
US6706023B1 (en) * | 1999-12-03 | 2004-03-16 | Bionix Development Corporation | Device for irrigation of a blind orifice |
US6245100B1 (en) | 2000-02-01 | 2001-06-12 | Cordis Corporation | Method for making a self-expanding stent-graft |
US7077848B1 (en) | 2000-03-11 | 2006-07-18 | John Hopkins University | Sutureless occular surgical methods and instruments for use in such methods |
AU2001250793A1 (en) * | 2000-03-13 | 2001-09-24 | The Dow Chemical Company | Flame retardant, high impact monovinylidene aromatic polymer composition |
US6478776B1 (en) * | 2000-04-05 | 2002-11-12 | Biocardia, Inc. | Implant delivery catheter system and methods for its use |
US6638239B1 (en) * | 2000-04-14 | 2003-10-28 | Glaukos Corporation | Apparatus and method for treating glaucoma |
US6375972B1 (en) | 2000-04-26 | 2002-04-23 | Control Delivery Systems, Inc. | Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof |
US6451373B1 (en) | 2000-08-04 | 2002-09-17 | Advanced Cardiovascular Systems, Inc. | Method of forming a therapeutic coating onto a surface of an implantable prosthesis |
ATE547080T1 (en) | 2000-08-30 | 2012-03-15 | Univ Johns Hopkins | DEVICES FOR INTRAOCULAR DRUG DELIVERY |
ATE367836T1 (en) | 2000-10-31 | 2007-08-15 | Cook Inc | COATED IMPLANTABLE MEDICAL DEVICES |
JP2004523275A (en) | 2000-12-22 | 2004-08-05 | アバンテク バスキュラー コーポレーション | Delivery of therapeutic drugs |
US6471980B2 (en) | 2000-12-22 | 2002-10-29 | Avantec Vascular Corporation | Intravascular delivery of mycophenolic acid |
US6713081B2 (en) | 2001-03-15 | 2004-03-30 | The United States Of America As Represented By The Department Of Health And Human Services | Ocular therapeutic agent delivery devices and methods for making and using such devices |
US20040022853A1 (en) | 2001-04-26 | 2004-02-05 | Control Delivery Systems, Inc. | Polymer-based, sustained release drug delivery system |
WO2002100318A2 (en) | 2001-06-12 | 2002-12-19 | Johns Hopkins University School Of Medicine | Reservoir device for intraocular drug delivery |
US7485113B2 (en) | 2001-06-22 | 2009-02-03 | Johns Hopkins University | Method for drug delivery through the vitreous humor |
US20030158598A1 (en) | 2001-09-17 | 2003-08-21 | Control Delivery Systems, Inc. | System for sustained-release delivery of anti-inflammatory agents from a coated medical device |
US6764470B2 (en) * | 2001-12-03 | 2004-07-20 | Roland P. Dimick | Ear plug medication administration device |
US20040047911A1 (en) | 2002-08-13 | 2004-03-11 | Medtronic, Inc. | Active agent delivery system including a poly(ethylene-co-(meth)Acrylate), medical device, and method |
CA2689424A1 (en) | 2002-09-29 | 2004-04-08 | Surmodics, Inc. | Methods for treatment and/or prevention of retinal disease |
US7654997B2 (en) * | 2004-04-21 | 2010-02-02 | Acclarent, Inc. | Devices, systems and methods for diagnosing and treating sinusitus and other disorders of the ears, nose and/or throat |
-
2001
- 2001-06-22 AT AT08014292T patent/ATE547080T1/en active
- 2001-06-22 AT AT01950424T patent/ATE404140T1/en not_active IP Right Cessation
- 2001-06-22 DK DK01950424T patent/DK1313415T3/en active
- 2001-06-22 US US09/888,092 patent/US6719750B2/en not_active Expired - Lifetime
- 2001-06-22 WO PCT/US2001/020119 patent/WO2002017831A2/en active Application Filing
- 2001-06-22 AU AU2001271417A patent/AU2001271417B2/en not_active Ceased
- 2001-06-22 JP JP2002522807A patent/JP4471568B2/en not_active Expired - Lifetime
- 2001-06-22 PT PT01950424T patent/PT1313415E/en unknown
- 2001-06-22 EP EP01950424A patent/EP1313415B1/en not_active Expired - Lifetime
- 2001-06-22 CA CA2420038A patent/CA2420038C/en not_active Expired - Fee Related
- 2001-06-22 DE DE60135352T patent/DE60135352D1/en not_active Expired - Lifetime
- 2001-06-22 EP EP08014292A patent/EP1992317B1/en not_active Expired - Lifetime
- 2001-06-22 AU AU7141701A patent/AU7141701A/en active Pending
- 2001-06-22 ES ES01950424T patent/ES2312456T3/en not_active Expired - Lifetime
-
2003
- 2003-12-19 US US10/740,698 patent/US8096972B2/en not_active Expired - Fee Related
-
2004
- 2004-04-12 US US10/823,089 patent/US20050059956A1/en not_active Abandoned
-
2007
- 2007-01-05 AU AU2007200057A patent/AU2007200057B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
ES2312456T3 (en) | 2009-03-01 |
AU2001271417B2 (en) | 2006-10-05 |
JP4471568B2 (en) | 2010-06-02 |
DE60135352D1 (en) | 2008-09-25 |
AU2007200057A1 (en) | 2007-01-25 |
US6719750B2 (en) | 2004-04-13 |
US8096972B2 (en) | 2012-01-17 |
US20050059956A1 (en) | 2005-03-17 |
AU7141701A (en) | 2002-03-13 |
ATE404140T1 (en) | 2008-08-15 |
EP1313415B1 (en) | 2008-08-13 |
US20040133155A1 (en) | 2004-07-08 |
WO2002017831A2 (en) | 2002-03-07 |
AU2007200057B2 (en) | 2008-09-18 |
EP1992317A2 (en) | 2008-11-19 |
WO2002017831A3 (en) | 2002-07-11 |
DK1313415T3 (en) | 2008-10-13 |
EP1992317A3 (en) | 2009-01-21 |
PT1313415E (en) | 2008-11-25 |
EP1313415A2 (en) | 2003-05-28 |
CA2420038C (en) | 2010-11-09 |
ATE547080T1 (en) | 2012-03-15 |
US20020026176A1 (en) | 2002-02-28 |
JP2004524866A (en) | 2004-08-19 |
EP1992317B1 (en) | 2012-02-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2420038A1 (en) | Devices for intraocular drug delivery | |
CA2450771A1 (en) | Reservoir device for intraocular drug delivery | |
US5800390A (en) | Equipment for intracerebral administration of preparations | |
US8870826B2 (en) | Combined otic aspirator and medication dispenser | |
US20030135153A1 (en) | Drug implant injection device | |
ES2326100T3 (en) | SYSTEM OF DIAGNOSIS AND TRANSFER OF FLUID IN THE INTERNAL EAR. | |
EP1441799B1 (en) | Device for delivering microdoses of agent to the ear | |
US6120484A (en) | Otological implant for delivery of medicament and method of using same | |
CN102186528B (en) | Inner ear drug delivery device | |
US8088112B2 (en) | Implantable medical site | |
ES2733398T3 (en) | Systems and methods for sub-retinal administration of therapeutic agents | |
US5911757A (en) | Methods and apparatus for transcutaneous access | |
JP2002513319A (en) | Trocar seal system | |
KR20090048600A (en) | Implantable neuro-stimulation electrode with fluid reservoir | |
AU2001271417A1 (en) | Devices for intraocular drug delivery | |
US20170348089A1 (en) | Adjustable breast implant with integral injection port | |
US9907695B2 (en) | Ophthalmic shunt and method | |
WO2012047931A1 (en) | Device for local drug delivery and treatment of cerebral edema and other brain-related diseases | |
US6726711B1 (en) | Artificial blood vessel with transcutaneous access ports | |
US10307289B2 (en) | Sub-cutaneous medicinal dosage delivery implant system | |
US7678088B2 (en) | Portkatheter | |
CZ298160B6 (en) | Apparatus for inducing an immune response in cancer therapy | |
ES2330100T3 (en) | IMPLANTABLE MEDICAL DEVICE FOR THE CONTROLLED RELEASE OF A SUBSTANCE. | |
US20230390108A1 (en) | Ocular drug delivery devices | |
TW201717861A (en) | A kit for introducing a bladder into a body pocket |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20130625 |