CA2411408A1 - Needle safety device - Google Patents

Needle safety device Download PDF

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Publication number
CA2411408A1
CA2411408A1 CA002411408A CA2411408A CA2411408A1 CA 2411408 A1 CA2411408 A1 CA 2411408A1 CA 002411408 A CA002411408 A CA 002411408A CA 2411408 A CA2411408 A CA 2411408A CA 2411408 A1 CA2411408 A1 CA 2411408A1
Authority
CA
Canada
Prior art keywords
safety shield
housing
needle
hub
needle cannula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002411408A
Other languages
French (fr)
Other versions
CA2411408C (en
Inventor
C. Mark Newby
Michael Bennett
Hugh T. Conway
Bradley M. Wilkinson
John Hitchings
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson and Co
Original Assignee
Becton Dickinson and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26861362&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2411408(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Becton Dickinson and Co filed Critical Becton Dickinson and Co
Publication of CA2411408A1 publication Critical patent/CA2411408A1/en
Application granted granted Critical
Publication of CA2411408C publication Critical patent/CA2411408C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/50—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
    • A61M5/5086—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile for indicating if defective, used, tampered with or unsterile
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/15003—Source of blood for venous or arterial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150259—Improved gripping, e.g. with high friction pattern or projections on the housing surface or an ergonometric shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150389—Hollow piercing elements, e.g. canulas, needles, for piercing the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150473—Double-ended needles, e.g. used with pre-evacuated sampling tubes
    • A61B5/150496—Details of construction of hub, i.e. element used to attach the double-ended needle to a piercing device or sampling device
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150534—Design of protective means for piercing elements for preventing accidental needle sticks, e.g. shields, caps, protectors, axially extensible sleeves, pivotable protective sleeves
    • A61B5/150572—Pierceable protectors, e.g. shields, caps, sleeves or films, e.g. for hygienic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150534—Design of protective means for piercing elements for preventing accidental needle sticks, e.g. shields, caps, protectors, axially extensible sleeves, pivotable protective sleeves
    • A61B5/15058—Joining techniques used for protective means
    • A61B5/150587—Joining techniques used for protective means by friction fit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150534—Design of protective means for piercing elements for preventing accidental needle sticks, e.g. shields, caps, protectors, axially extensible sleeves, pivotable protective sleeves
    • A61B5/150633—Protective sleeves which are axially extensible, e.g. sleeves connected to, or integrated in, the piercing or driving device; pivotable protective sleeves
    • A61B5/150641—Protective sleeves which are axially extensible, e.g. sleeves connected to, or integrated in, the piercing or driving device; pivotable protective sleeves comprising means to impede repositioning of protection sleeve from covering to uncovering position
    • A61B5/150648—Protective sleeves which are axially extensible, e.g. sleeves connected to, or integrated in, the piercing or driving device; pivotable protective sleeves comprising means to impede repositioning of protection sleeve from covering to uncovering position fully automatically triggered, i.e. the triggering of the protective sleeve does not require a deliberate action by the user such as terminating the contact with the patient's skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150534—Design of protective means for piercing elements for preventing accidental needle sticks, e.g. shields, caps, protectors, axially extensible sleeves, pivotable protective sleeves
    • A61B5/150633—Protective sleeves which are axially extensible, e.g. sleeves connected to, or integrated in, the piercing or driving device; pivotable protective sleeves
    • A61B5/150641—Protective sleeves which are axially extensible, e.g. sleeves connected to, or integrated in, the piercing or driving device; pivotable protective sleeves comprising means to impede repositioning of protection sleeve from covering to uncovering position
    • A61B5/150656—Protective sleeves which are axially extensible, e.g. sleeves connected to, or integrated in, the piercing or driving device; pivotable protective sleeves comprising means to impede repositioning of protection sleeve from covering to uncovering position semi-automatically triggered, i.e. in which the triggering of the protective sleeve requires a deliberate action by the user, e.g. manual release of spring-biased extension means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150534—Design of protective means for piercing elements for preventing accidental needle sticks, e.g. shields, caps, protectors, axially extensible sleeves, pivotable protective sleeves
    • A61B5/150694—Procedure for removing protection means at the time of piercing
    • A61B5/150717—Procedure for removing protection means at the time of piercing manually removed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150732—Needle holders, for instance for holding the needle by the hub, used for example with double-ended needle and pre-evacuated tube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150801—Means for facilitating use, e.g. by people with impaired vision; means for indicating when used correctly or incorrectly; means for alarming
    • A61B5/150824—Means for facilitating use, e.g. by people with impaired vision; means for indicating when used correctly or incorrectly; means for alarming by visual feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/153—Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
    • A61B5/154—Devices using pre-evacuated means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A61M5/3257—Semi-automatic sleeve extension, i.e. in which triggering of the sleeve extension requires a deliberate action by the user, e.g. manual release of spring-biased extension means

Abstract

A needle assembly includes a needle and a hub mounted to each other. The hub includes a sidewall spaced outwardly from the needle cannula and extending to a distal position between the opposed ends of the needle cannula. A housing integral with the hub defines a sidewall to partially confine a safety shield. The safety shield is slidably disposed about the needle cannula and releasably retained in a proximal position and can be moved to a distal position where the safety shield completely surrounds that portion of the needle hub projecting distally from the hub. The needle assembly includes a spring for propelling the safety shield to the distal position and a latch for releasing the safety shield from the proximal position. The latch may be passively activated by normal usage of the medical implement to which the needle assembly is mounted or alternately activated manually.

Claims (30)

1. A shieldable needle assembly comprising:
a needle cannula having a proximal end and a distal end;
a hub mounted to said needle cannula at a location spaced from said distal end of said needle cannula:
a substantially tubular housing projecting distally from said hub toward said distal end of said needle cannula, said tubular housing being spaced outwardly from said needle cannula;

a safety shield telescoped over said needle cannula and having at least a portion slidably disposed between said needle cannula and said housing, said safety shield being releasably retained in a proximal position where said safety shield is spaced from said distal end of said needle cannula, said safety shield being movable from said proximal position to a distal position where said safety shield surrounds portions of said needle cannula distally of said housing; and a spring for propelling said safety shield from said proximal position to said distal position.
2. The needle assembly of Claim 1, wherein one of said housing and said safety shield includes a latch, and wherein the other of said housing and said safety shield includes a detent for releasably engaging the latch and for releasably holding said safety shield in said proximal position.
3. The needle assembly of Claim 2, further comprising an actuator slidably mounted to said hub, said actuator having a proximal end extending proximally from said hub and a distal end substantially aligned with said latch, said actuator being movable distally relative to said hub and said safety shield, a portion of said actuator being configured for disengaging said latch from said detent in response to said movement of said actuator and enabling said spring to propel said safety shield to said distal position.
4. The needle assembly of Claim 3, wherein said actuator includes a portion disposed externally of said housing for permitting manual actuation.
5. The needle assembly of Claim 5, wherein said proximal end of said housing comprises a means for mounting onto a detachable holder useful for receiving collection containers, said holder comprising a distal end, an open proximal end, and a sidewall extending therebetween.
6. The needle assembly of Claim 5, wherein said proximal end of said actuator is movable in the distal direction by insertion of a collection container into the proximal end of said holder.
7. The blood collection assembly of Claim 5, wherein said actuator includes an actuator button disposed externally of said holder and a proximal end extending into said holder, said actuator including a distal end disposed adjacent said latch of said safety shield, wherein distal movement of said actuator is moveable by either insertion of a collection container into said proximal end of said holder or manual movement of said actuator button.
8. The needle assembly of Claim 2, wherein said housing includes a latch recess, said latch being on said safety shield and being engageable with said latch recess of said housing when said safety shield is in said distal position for preventing further distal movement of said safety shield from said distal position and for preventing a return proximal movement of said safety shield from said distal position.
9. The needle assembly of Claim 1, wherein the safety shield is substantially tubular and is spaced radially outwardly from said needle cannula, said spring being a coil spring surrounding said needle cannula and engaged with said tubular safety shield.
10. The needle assembly of Claim 9, wherein said coil spring exerts a spring force of 0.020-.020 pounds between said safety shield and one of said hub or said housing while said safety shield is in the proximal position.
11. The needle assembly of Claim 1, wherein said housing includes at least one non-cylindrical external region for digital gripping of said housing.
12. The needle assembly of Claim 11, wherein said distal end of said needle cannula is beveled to a point, said bevel being oriented with respect to non-cylindrical region of said housing.
13. The needle assembly of Claim 11, wherein said non-cylindrical region includes a pair of opposed flats extending longitudinally along portions of said housing on opposite respective sides of said housing, said flats each including at least one surface irregularity for facilitating gripping.
14. The needle assembly of Claim 1, further comprising a distal packaging cap removably disposed over said distal end of said needle cannula.
15. The needle assembly of Claim 14, wherein said proximal end of said needle cannula projects proximally from said hub, said needle assembly further comprising a proximal packing cap removably disposed over said proximal end of said needle cannula.
16. The needle assembly of Claim 1, wherein said housing is formed from a transparent plastic material.
17. The needle assembly of Claim 1, wherein said safety shield includes indicia for providing visual indications of movement of said shield relative to said housing.
18. The needle assembly of Claim 17, wherein said distal end of said needle cannula is beveled to a point, said indicia on said shield being aligned with said bevel.
19. A blood collection assembly comprising:
a substantially cylindrical holder having an open proximal end, a distal end and a tubular sidewall extending between said ends, said tubular sidewall being configured for possible insertion of a collection container, an end wall at said distal end of said holder, said end wall having a central aperture with needle mounting structure formed thereon: and a needle assembly comprising a needle cannula having a pointed proximal end and a pointed distal end, a hub mounted to said needy cannula between said pointed proximal end and said pointed distal end thereof, said hub including mounting means for mounting said hub to said mounting structure of said holder such that said pointed proximal end of said needle cannula projects into said holder, a housing spaced radially outwardly from said needle cannula and projecting distally from said distal end of said hub to a location spaced proximally from said distal end of said needle cannula, a safety shield surrounding said needle cannula and having at least a portion disposed between said needle cannula and said housing, said safety shield being releasably retained in a proximal position such that said safety shield is disposed proximally of said distal end of said needle cannula, said safety shield being movable to a distal position where said safety shield encloses said pointed distal end of said needle cannula, and a spring for propelling said safety shield from said proximal position to said distal position.
20. The blood collection assembly of Claim 1, wherein said housing includes a detent, and wherein said safety shield includes a latch for releasably retaining said safety shield in said proximal position.
21. The blood collection assembly of Claim 20, further comprising an actuator slidably engaged with said hub at said proximal end of said hub, said actuator including a proximal end disposed within said needle holder and a distal end disposed substantially adjacent said latch of said safety shield, said proximal end of said actuator being engageable by a collection container for urging said actuator distally and into a position for disengaging said latch from said detent on said housing.
22. The blood collection assembly of Claim 20, wherein said actuator includes an actuator button disposed externally of said holder and said needle assembly for permitting manual actuation of said safety shield.
23. The blood collection assembly of Claim 20, wherein said actuator includes an actuator button disposed externally of said holder and a proximal end extending into said holder, said actuator including a distal end disposed adjacent said latch of said safety shield, wherein distal movement of said actuator is moveable by either insertion of a collection container into said proximal end of said holder or manual movement of said actuator button.
24. The blood collection assembly of Claim 19, wherein said safety shield is substantially tubular and includes a sidewall spaced outwardly from said needle cannula, said spring being a coil spring surrounding said needle and engaged with said tubular safety shield.
25. The blood collection assembly of Claim 19, further comprising an openable closure over said open proximal end of said holder.
26. The blood collection assembly of Claim 19. wherein said holder includes a flange projecting outwardly at said proximal end, said flange including a flat edge aligned substantially perpendicular to a plane passing symmetrically through said distal end of said needle cannula.
27. The blood collection assembly of Claim 26, wherein said pointed distal end of said cannula comprises a bevel oriented to said flange of said holder.
28. The blood collection assembly of Claim 19, wherein said housing is formed from a transparent material.
29. The blood collection assembly of Claim 19, wherein said safety shield is formed with indicia for providing visible indication of movement of said safety shield relative to said housing.
30. A method of making a blood collection assembly comprising the steps of:
(a) providing the components of;
(i) a hub;
(ii) a needle cannula comprising a proximal end, a distal end, and a lumen extending therebetween, said cannula is mounted to said hub;
(iii) a housing engageable to said hub and extending distally from said hub, said housing comprising a safety shield guiding means;
(iv) a safety shield longitudinally moveable with respect to said housing by said safety shield guiding means from a proximal position to a distal position;
(v) a compression spring between one of said hub or said housing and said safety shield, said spring having a spring constant, a free length and compressed length;
(b) identifying a first friction force between a typical patient's skin and said needle cannula;
(c) identifying a second friction force between said blood collection assembly and a patient's skin;
(d) assembling said components wherein said shield has a proximal position, an intermediate position, and a fully extended distal position in relation to said housing;
(e) providing a spring constant and spring length combination suitable for said spring to exert a force on said safety shield that is in equilibrium with said first and second friction forces while said distal end of said cannula is percutaneously inserted into a patient's skin and said safety shield is in said intermediate position.
CA2411408A 2001-11-13 2002-11-08 Needle safety device Expired - Lifetime CA2411408C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US35420201P 2001-11-13 2001-11-13
US60/354,202 2001-11-13
US10/165,407 US6984223B2 (en) 2001-11-13 2002-06-07 Needle safety device
US10/165,407 2002-06-07

Publications (2)

Publication Number Publication Date
CA2411408A1 true CA2411408A1 (en) 2003-05-13
CA2411408C CA2411408C (en) 2010-10-19

Family

ID=26861362

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2411408A Expired - Lifetime CA2411408C (en) 2001-11-13 2002-11-08 Needle safety device

Country Status (7)

Country Link
US (2) US6984223B2 (en)
EP (3) EP2140898B1 (en)
JP (1) JP4961090B2 (en)
AT (1) ATE333912T1 (en)
AU (3) AU2002301950B2 (en)
CA (1) CA2411408C (en)
DE (1) DE60213354T3 (en)

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US20030093009A1 (en) 2003-05-15
US6984223B2 (en) 2006-01-10
DE60213354T2 (en) 2007-09-20
AU2009202997A1 (en) 2009-08-13
ATE333912T1 (en) 2006-08-15
DE60213354D1 (en) 2006-09-07
USRE43473E1 (en) 2012-06-12
AU2009202997B2 (en) 2014-01-30
CA2411408C (en) 2010-10-19
EP1316325B1 (en) 2006-07-26
EP2140898B1 (en) 2012-01-04
DE60213354T3 (en) 2017-09-21
EP2140898A1 (en) 2010-01-06
EP1316325A1 (en) 2003-06-04
EP2145640A1 (en) 2010-01-20
EP2145640B1 (en) 2014-06-11
JP2003199731A (en) 2003-07-15
EP1316325B2 (en) 2017-02-22
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JP4961090B2 (en) 2012-06-27
AU2002301950B2 (en) 2009-04-23

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