CA2409826A1 - Systems and methods for monitoring health and delivering drugs transdermally - Google Patents
Systems and methods for monitoring health and delivering drugs transdermally Download PDFInfo
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- CA2409826A1 CA2409826A1 CA002409826A CA2409826A CA2409826A1 CA 2409826 A1 CA2409826 A1 CA 2409826A1 CA 002409826 A CA002409826 A CA 002409826A CA 2409826 A CA2409826 A CA 2409826A CA 2409826 A1 CA2409826 A1 CA 2409826A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
- A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
- A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/683—Means for maintaining contact with the body
- A61B5/6832—Means for maintaining contact with the body using adhesives
- A61B5/6833—Adhesive patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
- A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
Abstract
The present invention pertains to a system and method for transdermal sampling, comprising: at least one sampler for retrieving and transferring at least one analyte obtained transdermally from the skin of a subject; at least one detector system for identifying and quantifying said at least one analyte;
and at least one logic module for: (i) receiving and storing input data from said at least one detector, (ii) relating the input data to other data obtained from the subject, (iii) displaying output information, (iv) transmitting the output information to another system, and (v) controlling the operation of said at least one sampler and at least one detector.
and at least one logic module for: (i) receiving and storing input data from said at least one detector, (ii) relating the input data to other data obtained from the subject, (iii) displaying output information, (iv) transmitting the output information to another system, and (v) controlling the operation of said at least one sampler and at least one detector.
Claims (107)
1. A transdermal sampling system, comprising:
at least one sampler for retrieving and transferring at least one analyte obtained transdermally from the skin of a subject;
at least one detector system for identifying and quantifying said at least one analyte; and at least one logic module for (i) receiving and storing input data from said at least one detector, (ii) relating the input data to other data obtained from the subject, (iii) displaying output information, (iv) transmitting the output information to another system, and (v) controlling the operation of said at.least one sampler and at least one detector.
at least one sampler for retrieving and transferring at least one analyte obtained transdermally from the skin of a subject;
at least one detector system for identifying and quantifying said at least one analyte; and at least one logic module for (i) receiving and storing input data from said at least one detector, (ii) relating the input data to other data obtained from the subject, (iii) displaying output information, (iv) transmitting the output information to another system, and (v) controlling the operation of said at.least one sampler and at least one detector.
2. The system of claim 1, wherein said at least one sampler is a microfabricated device comprising a microfluidic assembly.
3. The system of claim 2, wherein said microfluidic assembly comprises at least one reservoir and at least one conduit in communication with said reservoir fox retrieving and transmitting said at least one analyte through said at least one conduit, and said at least one detector is in association with said at least one conduit for detecting said at least one analyte received and transmitted through said at least one conduit.
4. The system of claim 1, wherein said at least one sampler further comprises means for enhancing permeability of the skin of a subject for retrieving said at least one analyte therefrom.
5. The system of claim 4, wherein said means for enhancing permeability comprises a microheater disposed to be in close proximity to a subject's skin surface, and configured for ablating a portion of the stratum corneum of the skin of a subject to allow collection of interstitial fluid from the subject's underlying viable epidermis.
6. The system of claim 4, wherein said means for enhancing permeability comprises a microheater disposed to be in close proximity to a subject's skin surface, and configured for ablating a portion of the stratum corneum of the skin of a subject to allow access to interstitial fluid from the subject's underlying viable epidermis.
7. The system of claim 4, wherein said means for enhancing permeability of the skin comprises a radiation source positioned for generating and directing radiation to a subject's skin surface, effective to ablate a portion of the stratum corneum of the skin of a subject, to allow collection of interstitial fluid from the subject's underlying viable epidermis.
8. The system of claim 7, wherein said radiation source is a light source.
9. The system of claim 8, wherein said light source is a laser.
10. The system of claim 4, wherein said means for enhancing permeability of the skin comprises a radiation source positioned for generating and directing radiation to a subject's skin surface, effective to ablate a portion of the stratum corneum of the skin of a subject, to allow diffusion from interstitial fluid from the subject's underlying viable epidermis.
11. The system of claim 4, wherein said means for enhancing permeability of the skin is at least one of: (i) means for chemically altering the surface of the skin; (ii) means for puncturing the surface of the skin; (iii) means for solubilizing the surface of the skin; (iv) means for illuminating the surface of the skin sufficient to cause ablation thereof; and (v) means for irradiating the surface of the skin to cause ablation thereof.
12. The system of claim 1, wherein:
said at least one sampler comprises a plurality of samplers; and said at least one detector system comprises a plurality of detector systems.
said at least one sampler comprises a plurality of samplers; and said at least one detector system comprises a plurality of detector systems.
13. The system of claim 1, wherein said at least one detector system comprises an optical detection system comprised of light sources effective to excite fluorophores, and at least one detector for detecting fluorescence from excited fluorophores.
14. The system of claim 13, wherein said light source comprises at least one LED.
15. The system of claim 13, wherein said light source comprises at least one laser.
16. The system of claim 3, wherein said at least one reservoir contains a fluid, and is positioned for transmitting the fluid to a subject's skin to promote flow of said at least one analyte into said at least one conduit.
17. The system of claim 16, wherein said fluid contained in said at least one reservoir is capable of permeating a subject's skin.
18. The system of claim 16, further comprising a breakable seal for retaining said fluid in said reservoir prior to sampling analytes from a subject.
19. The system of claim 1, further comprising an adhesive on said sampler for adhering the sampler to the skin of a subject.
20. The system of claim 1, further comprising at least one substance located in said sampler which is capable of binding an analyte of interest, and said substance being detectable by said at least one detector system.
21. The system of claim 16, further comprising a pump for pumping said fluid into contact with the skin of a subject.
22. The system of claim 21, further comprising a microheater disposed to be in close proximity to a subject's skin surface at a location proximate to where said fluid is pumped into contact with the skin of a subject, and is configured for ablating a portion of the stratum corneum of the skin of a subject.
23. The system of claim 1, further comprising means for monitoring predetermined physiological data as said other data, for relating to the input data by said at least one logic module.
24. The system of claim 1, further comprising means for monitoring environmental conditions data as said other data, far relating to the input data by said at least one logic module.
25. The system of claim 1, wherein said at least one detector system comprises a patch sensitive to at least one analyte for changing color in response to contact with said at least one analyte, and at least one detector for detecting a change in color of the patch.
26. A microfabricated device for allowing remote monitoring of a subject, comprising: at least one sampler unit body for retrieving and transferring at least one analyte obtained transdermally from the skin of a subject; at least one detector system connected to said at least one sampler unit body for identifying and quantifying at least one analyte obtained from a subject; and a transmitter/receiver for transmitting data relating to at least one analyte detected by said detection system to a logic module for processing thereby, and for allowing control of the microfabricated device by a logic module.
27. The device of claim 26, wherein the sample unit body further comprises a microfluidic assembly.
28. The device of claim 27, wherein said microfluidic assembly comprises at least one reservoir and at least one conduit in communication with said reservoir for retrieving and transmitting said at least one analyte through said at least one conduit, and said at least one detector being in association with said at least one conduit for detecting said at least one analyte which has been received and transmitted through said at least one conduit.
29. The device of claim 26, wherein said at least one sampler unit body further comprises means for enhancing permeability of the skin of a subject for retrieving said at least one analyte therefrom.
30. The device of claim 29, wherein said means for enhancing permeability comprises a microheater disposed to be in close proximity to a subject's skin surface, and configured for ablating a portion of the stratum corneum of the skin of a subject to allow collection of interstitial fluid from the subject's underlying viable epidermis.
31. The device of claim 29, wherein said means for enhancing permeability of the skin comprises a radiation source positioned for generating and directing radiation to a subject's skin surface, effective to ablate a portion of the stratum corneum of the skin of a subject, to allow diffusion from interstitial fluid from the subject's underlying viable epidermis.
32. The device of claim 31, wherein said radiation source is a light source.
33. The device of claim 32, wherein said light source is a laser.
34. The device of claim 29, wherein said means for enhancing permeability of the skin is at least one of; (i) means for chemically altering the surface of the skin, (ii) means for puncturing the surface of the skin, (iii) means for solubilizing the surface of the skin, (iv) means for illuminating the surface of the skin sufficient to cause ablation thereof, and (v) means for irradiating the surface of the skin to cause ablation thereof.
35. The device of claim 26, wherein;
said at least one sampler unit body comprises a plurality of sampling conduits; and said at least one detector system comprises a plurality of detector systems.
said at least one sampler unit body comprises a plurality of sampling conduits; and said at least one detector system comprises a plurality of detector systems.
36. The device of claim 1, wherein said at least one detector system comprises an optical detection system comprised of light sources effective to excite flurophores, and at least one detector for detecting fluorescence from excited fluorophores.
37. The device of claim 36, wherein said light source comprises at least one LED.
38. The device of claim 36, wherein said light source comprises at least one laser.
39. The device of claim 28, wherein said at least one reservoir contains a fluid, and is positioned for transmitting the fluid to a subject's skin to promote flow of said at least one analyte into said at least one conduit.
40. The device of claim 39, wherein said fluid contained in said at least one reservoir is capable of permeating a subject's skin.
41. The device of claim 39, further comprising a breakable seal for retaining said fluid in said reservoir prior to sampling analytes from a subject.
42. The device of claim 26, further comprising an adhesive on said sampler for adhering the sample to the skin of a subject.
43. The device of claim 26, further comprising at least one substance in said sampler unit body which is capable of binding an analyte of interest, and said substance being detectable by said at least one detector system.
44. The device of claim 26, wherein said at least one detector system comprises a patch sensitive to at least one analyte for changing color in response to contact with said at least one analyte, positioned in said sampler unit body for contact with said at least one analyte, and at least one detector in said sampler unit body positioned for detecting a change in color of the patch,
45. The device of claim 26, wherein said sampler unit body is a silicon body having an array of capillary conduits extending therethrough for sampling analyte from the skin of a subject through said capillary conduits; and at least one detector chamber associated with said at least one detection system, and in communication with said capillary conduits for detecting analytes received within the capillary chamber.
46. The device of claim 45, wherein said at least one sampler further comprises means for enhancing permeability of the skin of a subject for retrieving said at least one analyte therefrom.
47. The device of claim 46, wherein said means for enhancing permeability comprises a microheater disposed to be in close proximity to a subject's skin surface, and configured for ablating a portion of the stratum corneum of the skin of a subject to allow collection of interstitial fluid from the subject's underlying viable epidermis.
48. The device of claim 46, wherein said means for enhancing permeability comprises a microheater disposed to be in close proximity to a subject's skin surface, and configured for ablating a portion of the stratum corneum of the skin of a subject to allow diffusion from interstitial fluid from the subject's underlying viable epidermis.
49. The device of claim 46, wherein said means for enhancing permeability of the skin comprises a radiation source positioned for generating and directing radiation to a subject's skin surface, effective to ablate a portion of the stratum corneum of the skin of a subject to allow collection of interstitial fluid from the subject's underlying viable epidermis.
50. The device of claim 46, wherein said means for enhancing permeability of the skin comprises a radiation source positioned for generating and directing radiation to a subject's skin surface, effective to ablate a portion of the stratum corneum of the skin of a subject to allow diffusion from interstitial fluid from the subject's underlying viable epidermis.
51. The device of claim 50, wherein said radiation source is a light source.
52. The device of claim 51, wherein said light source is a laser.
53. The device of claim 46, wherein said means for enhancing permeability of the skin is at least one of; (i) means far chemically altering the surface of the skin, (ii) means for puncturing the surface of the skin, (iii) means for solubilizing the surface of the skin, (iv) means for illuminating the surface of the skin sufficient to cause ablation thereof, and (v) means for irradiating the surface of the skin to cause ablation thereof.
54. The device of claim 46, wherein said at least one detector system comprises an optical detection system comprised of light sources effective to excite flurophores, and at least one detector for detecting fluorescence from excited fluorophores.
55. The device of claim 54, wherein said light source comprises at least one LED.
56. The device of claim 54, wherein said light source comprises at least one laser.
57. The device of claim 46, wherein said silicon body comprises at least one reservoir capable of containing a fluid, and in communication with said capillary conduits, for transmitting the fluid to a subject's skin to promote flow of said at least one analyte into at least one of said capillary conduits.
58. The device of claim 57, wherein said silicon body further comprises a microheater disposed to be in close proximity to a subject's skin surface at a location proximate to where said fluid is pumped into contact with the skin of a subject, and is configured for ablating a portion of the stratum corneum of the skin of a subject.
59. A microfabricated device for sampling analytes from the skin of a subject, comprising:
a detection chamber for receiving analytes retrieved from the skin of a subject;
a photonic detection system, comprising a photonics source located attached to said microfabricated device in association with said detection chamber, and detectors associated with said detection chamber for detecting analytes received in said detection chamber.
a detection chamber for receiving analytes retrieved from the skin of a subject;
a photonic detection system, comprising a photonics source located attached to said microfabricated device in association with said detection chamber, and detectors associated with said detection chamber for detecting analytes received in said detection chamber.
60. The device of claim 59, wherein said photonics source is at least one LED.
61. The device of claim 59, wherein said photonics source is at least one laser.
62. The device of claim 59, further comprising substances in said device which bind with selected analytes, and which fluoresce when said photonics source applies radiation thereto.
63. A microfabricated device for sampling analytes from the skin of a subject, comprising:
a detection chamber for receiving analytes retrieved from the skin of a subject;
a patch which changes color when contacted by predetermined analytes, located attached to said microfabricated device in association with said detection chamber; and detectors associated with said detection chamber, for detecting a change of color of the patch indicating the presence of a predetermined analyte.
a detection chamber for receiving analytes retrieved from the skin of a subject;
a patch which changes color when contacted by predetermined analytes, located attached to said microfabricated device in association with said detection chamber; and detectors associated with said detection chamber, for detecting a change of color of the patch indicating the presence of a predetermined analyte.
64. A microfabricated device for sampling and detecting analytes retrieved from the skin of a subject, comprising:
at least one conduit for retrieving and transmitting an analyte from the skin of a subject to a detector; and means for enhancing permeability of the skin of a subject for retrieving said at least one analyte therefrom.
at least one conduit for retrieving and transmitting an analyte from the skin of a subject to a detector; and means for enhancing permeability of the skin of a subject for retrieving said at least one analyte therefrom.
65. The device of claim 64, wherein said means for enhancing permeability comprises a microheater disposed to be in close proximity to a subject's skin surface, and configured for ablating a portion of the stratum corneum of the skin of a subject to allow collection of interstitial fluid from the subject's underlying viable epidermis.
66. The device of claim 64, wherein said means for enhancing permeability comprises a microheater disposed to be in close proximity to a subject's skin surface, and configured for ablating a portion of the stratum corneum of the skin of a subject to allow diffusion from interstitial fluid from the subject's underlying viable epidermis.
67. The device of claim 64, wherein said means for enhancing permeability of the skin comprises a radiation source positioned for generating and directing radiation to a subject's skin surface, effective to ablate a portion of the stratum corneum of the skin of a subject, to allow collection of interstitial fluid from the subject's underlying viable epidermis.
68. The device of claim 64, wherein said means for enhancing permeability of the skin comprises a radiation source positioned for generating and directing radiation to a subject's skin surface, effective to ablate a portion of the stratum corneum of the skin of a subject, to allow diffusion from interstitial fluid from the subject's underlying viable epidermis.
69. The device of claim 67, wherein said radiation source is a light source.
70. The device of claim 69, wherein said light source is a laser.
71. The device of claim 64, wherein said means for enhancing permeability of the skin is at least one of: (i) means for chemically altering the surface of the skin; (ii) means for puncturing the surface of the skin; (iii) means for solubilizing the surface of the skin; (iv) means for illuminating the surface of the skin sufficient to cause ablation thereof; and (v) means for irradiating the surface of the skin to cause ablation thereof.
72. A transdermal sampling system, comprising:
a microfluidic assembly for retrieving and transferring at least one analyte obtained transdermally from the skin of a subject;
at least one detector system far identifying and quantifying said at least one analyte; and at least one logic module for (i) receiving and storing input data from said at least one detector, (ii) relating the input data to other data obtained from the subject, (iii) displaying output information, (iv) transmitting the output information to another system, and (v) controlling the operation of said at least one sampler and at least one detector.
a microfluidic assembly for retrieving and transferring at least one analyte obtained transdermally from the skin of a subject;
at least one detector system far identifying and quantifying said at least one analyte; and at least one logic module for (i) receiving and storing input data from said at least one detector, (ii) relating the input data to other data obtained from the subject, (iii) displaying output information, (iv) transmitting the output information to another system, and (v) controlling the operation of said at least one sampler and at least one detector.
73. The transdermal sampling system according to claim 72, wherein the microfluidic assembly comprises at least one serpentine capillary channel.
74. The transdermal sampling system according to claim 72, wherein the microfluidic assembly further comprises at least one reservoir channel, at least one bottom capping section, and at least one top capping section.
75. The transdermal sampling system according to claim 72, wherein the at least one reservoir channel further comprises at least one seal for retaining a physiologically compatible fluid within the at least one reservoir channel.
76. The transdermal sampling system according to claim 74, wherein the at least bottom capping section comprises a micro-heating element.
77. The transdermal sampling system according to claim 76, wherein the micro-heating element serves to ablate stratum corneum.
78. The transdermal sampling system according to claim 76, wherein the micro-heating element serves to rupture the at least one seal.
79. The transdermal sampling system according to claim 76, wherein the micro-heating element serves bath to ablate stratum corneum and to rupture the at least one seal.
80. The transdermal sampling system according to claim 74, wherein the at least one top capping section comprises two or more electrodes.
81. The transdermal sampling system according to claim 80, wherein the two or more electrodes serve to assist the flow of a physiologically compatible fluid through the at least one serpentine capillary channel.
82. The transdermal sampling system according to claim 74, wherein the microfluidic assembly further comprises a sensor for detecting the at least one analyte.
83. The transdermal sampling system according to claim 82, wherein the sensor comprises an optical detection system comprised of at least one light source effective to excite fluorophores, and at least one detector for detecting fluorescence from excited fluorophores.
84. The transdermal sampling system according to claim 83, wherein the at least one light source comprises at least one LED.
85. The transdermal sampling system according to claim 83, wherein the at least one light source comprises at least one laser.
86. The transdermal sampling system according to claim 82, wherein the sensor for detecting the at least one analyte comprises a patch sensitive to the at least one analyte for changing color in response to contact with the at least one analyte, and at least one detector for detecting a change in color of the patch.
87. A transdermal sampling system, comprising:
a microfluidic assembly for retrieving and transferring at least one analyte obtained transdermally from the 5km of a subject;
at least one detector system for identifying and quantifying said at least one analyte; and at least one logic module for (i) receiving and storing input data from said at least one detector, (ii) relating the input data to other data obtained from the subject, (iii) displaying output information, (iv) transmitting the output information to another system, and (v) controlling the operation of said at least one sampler and at least one detector, wherein the microfluidic assembly contains a physiologically compatible fluid for retrieving and transferring at least one analyte obtained transdermally from the skin of a subject, and wherein the microfluidic assembly is adhered to the skin of the subject.
a microfluidic assembly for retrieving and transferring at least one analyte obtained transdermally from the 5km of a subject;
at least one detector system for identifying and quantifying said at least one analyte; and at least one logic module for (i) receiving and storing input data from said at least one detector, (ii) relating the input data to other data obtained from the subject, (iii) displaying output information, (iv) transmitting the output information to another system, and (v) controlling the operation of said at least one sampler and at least one detector, wherein the microfluidic assembly contains a physiologically compatible fluid for retrieving and transferring at least one analyte obtained transdermally from the skin of a subject, and wherein the microfluidic assembly is adhered to the skin of the subject.
88. The transdermal sampling system according to claim 87, wherein the adhesion of the microfluidic assembly to the skin of the subject is achieved by means of an adhesive.
89. The transdermal sampling system according to claim 88, wherein the adhesive serves to prevent movement of the transdermal sampling system relative to the skin of the subject.
90. The transdermal sampling system according to claim 87, wherein the adhesive serves to prevent loss of the physiologically compatible fluid.
91. The transdermal sampling system according to claim 89, wherein the adhesive is water impermeable.
92. A transdermal sampling system, comprising:
a microfluidic assembly for retrieving and transferring at least one analyte obtained transdermally from the skin of a subject;
at least one detector system for identifying and quantifying said at least one analyte; and at least one logic module for (i) receiving and storing input data from said at least one detector, (ii) relating the input data to other data obtained from the subject, (iii) displaying output information, (iv) transmitting the output information to another system, and (v) controlling the operation of said at least one sampler and at least one detector, wherein at least one surface of the microfluidic assembly is modified.
a microfluidic assembly for retrieving and transferring at least one analyte obtained transdermally from the skin of a subject;
at least one detector system for identifying and quantifying said at least one analyte; and at least one logic module for (i) receiving and storing input data from said at least one detector, (ii) relating the input data to other data obtained from the subject, (iii) displaying output information, (iv) transmitting the output information to another system, and (v) controlling the operation of said at least one sampler and at least one detector, wherein at least one surface of the microfluidic assembly is modified.
93. The transdermal sampling system according to claim 92, wherein the modification of the at least one surface of the microfluidic assembly prevents the adsorption of protein to the at least one surface of the microfluidic assembly.
94. The transdermal sampling system according to claim 92, wherein the modification of the at least one surface of the microfluidic assembly attaches to the at least one surface of the microfluidic assembly at least one specific-binding molecule which specifically binds the at least one analyte.
95. The transdermal sampling system according to claim 94, wherein the at least one specific-binding molecule is bound with at least one fluorescently labeled analyte, wherein the at least one analyte obtained transdermally from the skin of a subject displaces the bound at least one fluorescently labeled analyte, and wherein measurement of the amount of fluorescence displaced from the at least one specific-binding molecule correlates with the amount of the at least one analyte obtained transdermally from the skin of a subject.
96. The transdermal sampling system according to claim 94, wherein the at least one specific-binding molecule is an antibody which specifically binds the at least one analyze.
97. The transdermal sampling system according to claim 94, wherein the at least one specific-binding molecule is an antibody fragment which specifically binds the at least one analyte.
98. The transdermal sampling system according to claim 94, wherein the at least one specific-binding molecule is an artificial antibody which specifically binds the at least one analyte.
99. The transdermal sampling system according to claim 94, wherein the at least one specific-binding molecule is an artificial antibody which specifically binds the at least one analyte.
100. The transdermal sampling system according to claim 94, wherein the at least one specific-binding molecule is a lectin which specifically binds the at least one analyte.
101. The transdermal sampling system according to claim 94, wherein the at least one specific-binding molecule is a hybridizable nucleic acid which specifically binds the at least one analyte.
102. The transdermal sampling system according to claim 94, wherein the at least one specific-binding molecule is a nucleic acid-binding protein which specifically binds the at least one analyte.
103. The transdermal sampling system according to claim 94, wherein the at least one specific-binding molecule is a protein-binding protein which specifically binds the at least one analyte.
104. The transdermal sampling system according to claim 94, wherein the at least one specific-binding molecule is a cofactor-binding protein which specifically binds the at least one analyte.
105. A method of biomedically monitoring a subject's condition, comprising:
ablating a subject's skin to allow interstitial fluid to perfuse therethrough;
collecting interstitial fluid from the subject's ablated skin;
identifying and quantifying at least one type of selected molecules contained in the collected interstitial fluid.
ablating a subject's skin to allow interstitial fluid to perfuse therethrough;
collecting interstitial fluid from the subject's ablated skin;
identifying and quantifying at least one type of selected molecules contained in the collected interstitial fluid.
106. The method of claim 105, wherein the at least one type of molecule is a metabolic marker of stress.
107. The method of claim 105, wherein the at least one type of molecule is at least one of an organophosphate, microbial toxin, inflammatory sequeli to microbial toxin, spore metabolite, prealbumin, C-reactive protein, troponin I, estrogen, and testosterone.
I08. The method of claim 105, further comprising monitoring at least one of the subject's vital physiologically statistics.
109. The method of claim 108, wherein said at least one of the subject's vital physiological statistics comprises at least one of body temperature, pulse rate, blood pressure, and heart activity.
110. The method of claim 105, further comprising monitoring and detecting environmental conditions in which the subject is located.
111. The method of claim 105, wherein said identifying and quantifying comprises transferring said at least one type of molecule to a patch which changes color when in contact with said at least one type of molecule, and detecting a change in color of the patch.
112. The method of claim 105, wherein said identifying and quantifying comprises binding the at least one type of molecule with a second type of molecule which fluoresces when irradiated, irradiating the at least one type of molecule bound to the second type of molecule, and detecting any resultant fluorescence.
113. The method of claim 112, wherein the radiation source is a laser.
114. The method of claim 112, wherein the radiation source is an LED.
I08. The method of claim 105, further comprising monitoring at least one of the subject's vital physiologically statistics.
109. The method of claim 108, wherein said at least one of the subject's vital physiological statistics comprises at least one of body temperature, pulse rate, blood pressure, and heart activity.
110. The method of claim 105, further comprising monitoring and detecting environmental conditions in which the subject is located.
111. The method of claim 105, wherein said identifying and quantifying comprises transferring said at least one type of molecule to a patch which changes color when in contact with said at least one type of molecule, and detecting a change in color of the patch.
112. The method of claim 105, wherein said identifying and quantifying comprises binding the at least one type of molecule with a second type of molecule which fluoresces when irradiated, irradiating the at least one type of molecule bound to the second type of molecule, and detecting any resultant fluorescence.
113. The method of claim 112, wherein the radiation source is a laser.
114. The method of claim 112, wherein the radiation source is an LED.
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2444980C2 (en) * | 2007-03-07 | 2012-03-20 | Эко Терапьютикс, Инк. | Transdermal system of analite monitoring and methods of analite detection |
Families Citing this family (295)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6036924A (en) | 1997-12-04 | 2000-03-14 | Hewlett-Packard Company | Cassette of lancet cartridges for sampling blood |
US6391005B1 (en) | 1998-03-30 | 2002-05-21 | Agilent Technologies, Inc. | Apparatus and method for penetration with shaft having a sensor for sensing penetration depth |
US20040039342A1 (en) | 2000-06-08 | 2004-02-26 | Jonathan Eppstein | Transdermal integrated actuator device, methods of making and using same |
JP4578041B2 (en) | 1999-08-09 | 2010-11-10 | ソナベーション, インコーポレイテッド | Piezoelectric fingerprint scanner |
JP2003527906A (en) | 2000-03-23 | 2003-09-24 | クロス マッチ テクノロジーズ, インコーポレイテッド | Piezoelectric identification device and its application |
US6887202B2 (en) | 2000-06-01 | 2005-05-03 | Science Applications International Corporation | Systems and methods for monitoring health and delivering drugs transdermally |
US8641644B2 (en) | 2000-11-21 | 2014-02-04 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
GB0030929D0 (en) * | 2000-12-19 | 2001-01-31 | Inverness Medical Ltd | Analyte measurement |
EP1384076B1 (en) | 2001-03-19 | 2012-07-25 | Gyros Patent Ab | Characterization of reaction variables |
US7041068B2 (en) | 2001-06-12 | 2006-05-09 | Pelikan Technologies, Inc. | Sampling module device and method |
WO2002100460A2 (en) | 2001-06-12 | 2002-12-19 | Pelikan Technologies, Inc. | Electric lancet actuator |
US8337419B2 (en) | 2002-04-19 | 2012-12-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US9226699B2 (en) | 2002-04-19 | 2016-01-05 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling module with a continuous compression tissue interface surface |
ES2357887T3 (en) | 2001-06-12 | 2011-05-03 | Pelikan Technologies Inc. | APPARATUS FOR IMPROVING THE BLOOD OBTAINING SUCCESS RATE FROM A CAPILLARY PUNCTURE. |
US7981056B2 (en) | 2002-04-19 | 2011-07-19 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
AU2002348683A1 (en) | 2001-06-12 | 2002-12-23 | Pelikan Technologies, Inc. | Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge |
US9795747B2 (en) | 2010-06-02 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
EP1404232B1 (en) | 2001-06-12 | 2009-12-02 | Pelikan Technologies Inc. | Blood sampling apparatus and method |
US9427532B2 (en) | 2001-06-12 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7316700B2 (en) | 2001-06-12 | 2008-01-08 | Pelikan Technologies, Inc. | Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties |
US20030072058A1 (en) * | 2001-08-09 | 2003-04-17 | Jespersen Soren Kragh | Electronic appliance |
US7769432B2 (en) * | 2001-12-10 | 2010-08-03 | Board Of Trustees Of The University Of Arkansas | Minimally invasive diagnosis and treatment for breast cancer |
US9918665B2 (en) * | 2002-03-11 | 2018-03-20 | Nitto Denko Corporation | Transdermal porator and patch system and method for using same |
US8116860B2 (en) | 2002-03-11 | 2012-02-14 | Altea Therapeutics Corporation | Transdermal porator and patch system and method for using same |
US9795334B2 (en) | 2002-04-19 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7547287B2 (en) | 2002-04-19 | 2009-06-16 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8579831B2 (en) | 2002-04-19 | 2013-11-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7708701B2 (en) | 2002-04-19 | 2010-05-04 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device |
US7909778B2 (en) | 2002-04-19 | 2011-03-22 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8221334B2 (en) | 2002-04-19 | 2012-07-17 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7901362B2 (en) | 2002-04-19 | 2011-03-08 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7648468B2 (en) | 2002-04-19 | 2010-01-19 | Pelikon Technologies, Inc. | Method and apparatus for penetrating tissue |
US7291117B2 (en) | 2002-04-19 | 2007-11-06 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7674232B2 (en) | 2002-04-19 | 2010-03-09 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8702624B2 (en) | 2006-09-29 | 2014-04-22 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
US8360992B2 (en) | 2002-04-19 | 2013-01-29 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7371247B2 (en) | 2002-04-19 | 2008-05-13 | Pelikan Technologies, Inc | Method and apparatus for penetrating tissue |
US8784335B2 (en) | 2002-04-19 | 2014-07-22 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling device with a capacitive sensor |
US7976476B2 (en) | 2002-04-19 | 2011-07-12 | Pelikan Technologies, Inc. | Device and method for variable speed lancet |
US7297122B2 (en) | 2002-04-19 | 2007-11-20 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US9248267B2 (en) | 2002-04-19 | 2016-02-02 | Sanofi-Aventis Deustchland Gmbh | Tissue penetration device |
US8267870B2 (en) | 2002-04-19 | 2012-09-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling with hybrid actuation |
US7331931B2 (en) | 2002-04-19 | 2008-02-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7232451B2 (en) | 2002-04-19 | 2007-06-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7892183B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
US7491178B2 (en) | 2002-04-19 | 2009-02-17 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7175642B2 (en) | 2002-04-19 | 2007-02-13 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
US7717863B2 (en) | 2002-04-19 | 2010-05-18 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US9314194B2 (en) | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7229458B2 (en) | 2002-04-19 | 2007-06-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8372016B2 (en) | 2002-04-19 | 2013-02-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling and analyte sensing |
US8574895B2 (en) | 2002-12-30 | 2013-11-05 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus using optical techniques to measure analyte levels |
US7417782B2 (en) | 2005-02-23 | 2008-08-26 | Pixtronix, Incorporated | Methods and apparatus for spatial light modulation |
US7354429B2 (en) * | 2003-05-27 | 2008-04-08 | Integrated Sensing Systems, Inc. | Device and method for detecting and treating chemical and biological agents |
ES2347248T3 (en) | 2003-05-30 | 2010-10-27 | Pelikan Technologies Inc. | PROCEDURE AND APPLIANCE FOR FLUID INJECTION. |
US7850621B2 (en) | 2003-06-06 | 2010-12-14 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
WO2006001797A1 (en) | 2004-06-14 | 2006-01-05 | Pelikan Technologies, Inc. | Low pain penetrating |
WO2005084534A1 (en) * | 2003-09-03 | 2005-09-15 | Life Patch International, Inc. | Personal diagnostic devices and related methods |
WO2005033659A2 (en) | 2003-09-29 | 2005-04-14 | Pelikan Technologies, Inc. | Method and apparatus for an improved sample capture device |
US9351680B2 (en) | 2003-10-14 | 2016-05-31 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a variable user interface |
US8016811B2 (en) | 2003-10-24 | 2011-09-13 | Altea Therapeutics Corporation | Method for transdermal delivery of permeant substances |
EP1682211B1 (en) | 2003-10-27 | 2009-11-18 | Universität Basel | Transdermal drug delivery system |
US8668656B2 (en) | 2003-12-31 | 2014-03-11 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for improving fluidic flow and sample capture |
US7822454B1 (en) | 2005-01-03 | 2010-10-26 | Pelikan Technologies, Inc. | Fluid sampling device with improved analyte detecting member configuration |
US8828203B2 (en) | 2004-05-20 | 2014-09-09 | Sanofi-Aventis Deutschland Gmbh | Printable hydrogels for biosensors |
WO2006004595A2 (en) * | 2004-05-28 | 2006-01-12 | Georgia Tech Research Corporation | Methods and devices for thermal treatment |
US20090318846A1 (en) * | 2004-05-28 | 2009-12-24 | Georgia Tech Research Corporation | Methods and apparatus for surface ablation |
EP1765194A4 (en) | 2004-06-03 | 2010-09-29 | Pelikan Technologies Inc | Method and apparatus for a fluid sampling device |
US9775553B2 (en) | 2004-06-03 | 2017-10-03 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a fluid sampling device |
AU2005262444A1 (en) * | 2004-07-01 | 2006-01-19 | Vivomedical, Inc. | Non-invasive glucose measurement |
US20070027383A1 (en) * | 2004-07-01 | 2007-02-01 | Peyser Thomas A | Patches, systems, and methods for non-invasive glucose measurement |
DE102004039570B4 (en) * | 2004-08-14 | 2007-03-01 | Lts Lohmann Therapie-Systeme Ag | Monitoring system for collecting and transdermal further diffusion of environmental contaminants containing air and method thereto |
US9820658B2 (en) | 2006-06-30 | 2017-11-21 | Bao Q. Tran | Systems and methods for providing interoperability among healthcare devices |
US7780981B2 (en) | 2004-09-13 | 2010-08-24 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery |
US8252321B2 (en) | 2004-09-13 | 2012-08-28 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like |
JP2008522745A (en) * | 2004-12-09 | 2008-07-03 | フレキシブル メディカル システムズ, エルエルシー | Apparatus and method for continuous real-time tracking biomolecule sampling, analysis, and delivery |
US8652831B2 (en) | 2004-12-30 | 2014-02-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte measurement test time |
US7545272B2 (en) | 2005-02-08 | 2009-06-09 | Therasense, Inc. | RF tag on test strips, test strip vials and boxes |
US9082353B2 (en) | 2010-01-05 | 2015-07-14 | Pixtronix, Inc. | Circuits for controlling display apparatus |
US8519945B2 (en) | 2006-01-06 | 2013-08-27 | Pixtronix, Inc. | Circuits for controlling display apparatus |
US7999994B2 (en) | 2005-02-23 | 2011-08-16 | Pixtronix, Inc. | Display apparatus and methods for manufacture thereof |
US8159428B2 (en) | 2005-02-23 | 2012-04-17 | Pixtronix, Inc. | Display methods and apparatus |
US8482496B2 (en) | 2006-01-06 | 2013-07-09 | Pixtronix, Inc. | Circuits for controlling MEMS display apparatus on a transparent substrate |
US7675665B2 (en) | 2005-02-23 | 2010-03-09 | Pixtronix, Incorporated | Methods and apparatus for actuating displays |
US7742016B2 (en) | 2005-02-23 | 2010-06-22 | Pixtronix, Incorporated | Display methods and apparatus |
US8310442B2 (en) | 2005-02-23 | 2012-11-13 | Pixtronix, Inc. | Circuits for controlling display apparatus |
US9229222B2 (en) | 2005-02-23 | 2016-01-05 | Pixtronix, Inc. | Alignment methods in fluid-filled MEMS displays |
US7755582B2 (en) | 2005-02-23 | 2010-07-13 | Pixtronix, Incorporated | Display methods and apparatus |
US7746529B2 (en) | 2005-02-23 | 2010-06-29 | Pixtronix, Inc. | MEMS display apparatus |
US9261694B2 (en) | 2005-02-23 | 2016-02-16 | Pixtronix, Inc. | Display apparatus and methods for manufacture thereof |
US9158106B2 (en) | 2005-02-23 | 2015-10-13 | Pixtronix, Inc. | Display methods and apparatus |
US20070205969A1 (en) | 2005-02-23 | 2007-09-06 | Pixtronix, Incorporated | Direct-view MEMS display devices and methods for generating images thereon |
NL1028619C2 (en) * | 2005-03-24 | 2006-09-27 | Alb Van Gool R & D | Method and device for determining the state of an entity, in particular the state of health of a human or animal. |
WO2006121510A2 (en) | 2005-05-09 | 2006-11-16 | Theranos, Inc. | Point-of-care fluidic systems and uses thereof |
US7578167B2 (en) * | 2005-05-17 | 2009-08-25 | Honeywell International Inc. | Three-wafer channel structure for a fluid analyzer |
WO2006127905A2 (en) | 2005-05-24 | 2006-11-30 | Chrono Therapeutics, Inc. | Portable drug delivery device |
FR2887425A1 (en) * | 2005-06-22 | 2006-12-29 | Annick Nicole Lydie Tournefier | ELECTROPHYSIOLOGICAL ANALYSIS SYSTEM |
US7733224B2 (en) | 2006-06-30 | 2010-06-08 | Bao Tran | Mesh network personal emergency response appliance |
WO2007050040A1 (en) * | 2005-10-28 | 2007-05-03 | Agency For Science, Technology And Research | Immobilization unit and device for isolation of nucleic acid molecules |
US8034719B1 (en) * | 2005-12-08 | 2011-10-11 | The United States Of America As Represented By The Secretary Of The Navy | Method of fabricating high aspect ratio metal structures |
US8333874B2 (en) * | 2005-12-09 | 2012-12-18 | Flexible Medical Systems, Llc | Flexible apparatus and method for monitoring and delivery |
US8526096B2 (en) | 2006-02-23 | 2013-09-03 | Pixtronix, Inc. | Mechanical light modulators with stressed beams |
WO2007108109A1 (en) * | 2006-03-15 | 2007-09-27 | Johoku Chemical Co., Ltd | Stabilized polyolefin resin and method of stabilizing polyolefin resin |
US8741230B2 (en) | 2006-03-24 | 2014-06-03 | Theranos, Inc. | Systems and methods of sample processing and fluid control in a fluidic system |
US11287421B2 (en) | 2006-03-24 | 2022-03-29 | Labrador Diagnostics Llc | Systems and methods of sample processing and fluid control in a fluidic system |
US8442281B2 (en) * | 2006-04-28 | 2013-05-14 | The Invention Science Fund I, Llc | Artificially displaying information relative to a body |
US8007999B2 (en) | 2006-05-10 | 2011-08-30 | Theranos, Inc. | Real-time detection of influenza virus |
US8684922B2 (en) | 2006-05-12 | 2014-04-01 | Bao Tran | Health monitoring system |
US8500636B2 (en) | 2006-05-12 | 2013-08-06 | Bao Tran | Health monitoring appliance |
US8968195B2 (en) | 2006-05-12 | 2015-03-03 | Bao Tran | Health monitoring appliance |
US7558622B2 (en) | 2006-05-24 | 2009-07-07 | Bao Tran | Mesh network stroke monitoring appliance |
US9060683B2 (en) | 2006-05-12 | 2015-06-23 | Bao Tran | Mobile wireless appliance |
US8323189B2 (en) | 2006-05-12 | 2012-12-04 | Bao Tran | Health monitoring appliance |
US7539532B2 (en) | 2006-05-12 | 2009-05-26 | Bao Tran | Cuffless blood pressure monitoring appliance |
US7539533B2 (en) | 2006-05-16 | 2009-05-26 | Bao Tran | Mesh network monitoring appliance |
US8684900B2 (en) | 2006-05-16 | 2014-04-01 | Bao Tran | Health monitoring appliance |
US20070276211A1 (en) * | 2006-05-26 | 2007-11-29 | Jose Mir | Compact minimally invasive biomedical monitor |
US7876489B2 (en) | 2006-06-05 | 2011-01-25 | Pixtronix, Inc. | Display apparatus with optical cavities |
US20070282246A1 (en) * | 2006-06-05 | 2007-12-06 | Mit, Llp | Iontosonic-microneedle biosensor apparatus and methods |
US20100100005A1 (en) * | 2006-07-11 | 2010-04-22 | Infotonics Technology Center, Inc. | Minimally invasive allergy testing system with coated allergens |
EP1887340A1 (en) * | 2006-08-11 | 2008-02-13 | Molecular Machines & Industries AG | Method and device for cutting and collecting dissected specimens |
US8012744B2 (en) | 2006-10-13 | 2011-09-06 | Theranos, Inc. | Reducing optical interference in a fluidic device |
US20080094853A1 (en) | 2006-10-20 | 2008-04-24 | Pixtronix, Inc. | Light guides and backlight systems incorporating light redirectors at varying densities |
US20080113391A1 (en) | 2006-11-14 | 2008-05-15 | Ian Gibbons | Detection and quantification of analytes in bodily fluids |
US8979755B2 (en) * | 2006-12-08 | 2015-03-17 | The Boeing Company | Devices and systems for remote physiological monitoring |
US8032197B2 (en) * | 2006-12-21 | 2011-10-04 | Bayer Healthcare Llc | Method of analyzing for at least one disease or condition marker |
US20080152592A1 (en) * | 2006-12-21 | 2008-06-26 | Bayer Healthcare Llc | Method of therapeutic drug monitoring |
US10525246B2 (en) * | 2006-12-22 | 2020-01-07 | Nanomed Skincare, Inc. | Microdevice and method for transdermal delivery and sampling of active substances |
US20080214987A1 (en) * | 2006-12-22 | 2008-09-04 | Nanomed Devices, Inc. | Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances |
US9176318B2 (en) | 2007-05-18 | 2015-11-03 | Pixtronix, Inc. | Methods for manufacturing fluid-filled MEMS displays |
US7852546B2 (en) | 2007-10-19 | 2010-12-14 | Pixtronix, Inc. | Spacers for maintaining display apparatus alignment |
CA2676255C (en) * | 2007-01-22 | 2016-06-07 | Altea Therapeutics Corporation | Transdermal porator and patch system and method for using same |
FR2912893B1 (en) * | 2007-02-23 | 2009-12-11 | Philippe Brunswick | ELECTROPHYSIOLOGICAL ANALYSIS SYSTEM |
KR20090128499A (en) * | 2007-03-19 | 2009-12-15 | 인슐린 메디컬 엘티디 | Drug delivery device |
US9220837B2 (en) * | 2007-03-19 | 2015-12-29 | Insuline Medical Ltd. | Method and device for drug delivery |
US8622991B2 (en) * | 2007-03-19 | 2014-01-07 | Insuline Medical Ltd. | Method and device for drug delivery |
US20100210932A1 (en) * | 2007-03-20 | 2010-08-19 | Bayer Healthcare Llc | Method of analyzing an analyte |
US7884727B2 (en) | 2007-05-24 | 2011-02-08 | Bao Tran | Wireless occupancy and day-light sensing |
US8268638B2 (en) | 2007-07-18 | 2012-09-18 | Advantageous Systems, Llc | Methods and apparatuses for detecting analytes in biological fluid of an animal |
US8158430B1 (en) | 2007-08-06 | 2012-04-17 | Theranos, Inc. | Systems and methods of fluidic sample processing |
US8328720B2 (en) * | 2007-08-10 | 2012-12-11 | Infotonics Technology Center, Inc. | MEMS interstitial prothrombin time test |
US20090163977A1 (en) * | 2007-08-17 | 2009-06-25 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | System, devices, and methods including sterilizing excitation delivery implants with cryptographic logic components |
US8734718B2 (en) * | 2007-08-17 | 2014-05-27 | The Invention Science Fund I, Llc | Systems, devices, and methods including catheters having an actively controllable therapeutic agent delivery component |
US20090048648A1 (en) * | 2007-08-17 | 2009-02-19 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Self-sterilizing device |
US8366652B2 (en) * | 2007-08-17 | 2013-02-05 | The Invention Science Fund I, Llc | Systems, devices, and methods including infection-fighting and monitoring shunts |
US20110160644A1 (en) * | 2007-08-17 | 2011-06-30 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems, devices, and methods including catheters configured to release ultraviolet energy absorbing agents |
US9005263B2 (en) * | 2007-08-17 | 2015-04-14 | The Invention Science Fund I, Llc | System, devices, and methods including actively-controllable sterilizing excitation delivery implants |
SG188082A1 (en) | 2007-10-02 | 2013-03-28 | Theranos Inc | Modular point-of-care devices and uses thereof |
US20100256610A1 (en) * | 2007-10-25 | 2010-10-07 | Basil Rigas | Apparatus and method of detection and localized treatment of abnormal conditions |
US20110160640A1 (en) * | 2008-01-18 | 2011-06-30 | Yanaki Jamal S | Operation management of active transdermal medicament patch |
US8862223B2 (en) * | 2008-01-18 | 2014-10-14 | Activatek, Inc. | Active transdermal medicament patch and circuit board for same |
JP5374682B2 (en) * | 2008-03-24 | 2013-12-25 | 静岡県公立大学法人 | Stress state evaluation method and stress state evaluation reagent kit |
US9386944B2 (en) | 2008-04-11 | 2016-07-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte detecting device |
US8248560B2 (en) | 2008-04-18 | 2012-08-21 | Pixtronix, Inc. | Light guides and backlight systems incorporating prismatic structures and light redirectors |
US20090312595A1 (en) * | 2008-04-24 | 2009-12-17 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | System and method for memory modification |
US8876688B2 (en) | 2008-04-24 | 2014-11-04 | The Invention Science Fund I, Llc | Combination treatment modification methods and systems |
US8930208B2 (en) | 2008-04-24 | 2015-01-06 | The Invention Science Fund I, Llc | Methods and systems for detecting a bioactive agent effect |
US20100130811A1 (en) * | 2008-04-24 | 2010-05-27 | Searete Llc | Computational system and method for memory modification |
US20100100036A1 (en) * | 2008-04-24 | 2010-04-22 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational System and Method for Memory Modification |
US9449150B2 (en) | 2008-04-24 | 2016-09-20 | The Invention Science Fund I, Llc | Combination treatment selection methods and systems |
US9662391B2 (en) | 2008-04-24 | 2017-05-30 | The Invention Science Fund I Llc | Side effect ameliorating combination therapeutic products and systems |
US9282927B2 (en) | 2008-04-24 | 2016-03-15 | Invention Science Fund I, Llc | Methods and systems for modifying bioactive agent use |
US20100063368A1 (en) * | 2008-04-24 | 2010-03-11 | Searete Llc, A Limited Liability Corporation | Computational system and method for memory modification |
US9649469B2 (en) | 2008-04-24 | 2017-05-16 | The Invention Science Fund I Llc | Methods and systems for presenting a combination treatment |
US9064036B2 (en) | 2008-04-24 | 2015-06-23 | The Invention Science Fund I, Llc | Methods and systems for monitoring bioactive agent use |
US9026369B2 (en) | 2008-04-24 | 2015-05-05 | The Invention Science Fund I, Llc | Methods and systems for presenting a combination treatment |
US20100069724A1 (en) * | 2008-04-24 | 2010-03-18 | Searete Llc | Computational system and method for memory modification |
US9560967B2 (en) | 2008-04-24 | 2017-02-07 | The Invention Science Fund I Llc | Systems and apparatus for measuring a bioactive agent effect |
US9239906B2 (en) | 2008-04-24 | 2016-01-19 | The Invention Science Fund I, Llc | Combination treatment selection methods and systems |
JP2010266203A (en) * | 2008-05-20 | 2010-11-25 | Sony Corp | Method and device for acquisition of biological information, and method and device for measurement of physiologically active substance |
US8169679B2 (en) | 2008-10-27 | 2012-05-01 | Pixtronix, Inc. | MEMS anchors |
US20110160681A1 (en) * | 2008-12-04 | 2011-06-30 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems, devices, and methods including catheters having light removable coatings based on a sensed condition |
US20110208021A1 (en) * | 2008-12-04 | 2011-08-25 | Goodall Eleanor V | Systems, devices, and methods including implantable devices with anti-microbial properties |
US20110208026A1 (en) * | 2008-12-04 | 2011-08-25 | Goodall Eleanor V | Systems, devices, and methods including implantable devices with anti-microbial properties |
US20110152751A1 (en) * | 2008-12-04 | 2011-06-23 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems, devices, and methods including catheters having UV-Energy emitting coatings |
US20110295090A1 (en) | 2008-12-04 | 2011-12-01 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems, devices, and methods including implantable devices with anti-microbial properties |
US9375169B2 (en) | 2009-01-30 | 2016-06-28 | Sanofi-Aventis Deutschland Gmbh | Cam drive for managing disposable penetrating member actions with a single motor and motor and control system |
WO2012018486A2 (en) | 2010-07-26 | 2012-02-09 | Seventh Sense Biosystems, Inc. | Rapid delivery and/or receiving of fluids |
EP2408369A1 (en) | 2009-03-02 | 2012-01-25 | Seventh Sense Biosystems, Inc. | Devices and methods for the analysis of an extractable medium |
US9033898B2 (en) | 2010-06-23 | 2015-05-19 | Seventh Sense Biosystems, Inc. | Sampling devices and methods involving relatively little pain |
US9041541B2 (en) | 2010-01-28 | 2015-05-26 | Seventh Sense Biosystems, Inc. | Monitoring or feedback systems and methods |
US20100286600A1 (en) * | 2009-05-08 | 2010-11-11 | Bommannan D Bommi | Transdermal patch device |
US20120224053A1 (en) * | 2009-06-17 | 2012-09-06 | Board Of Regents, The University Of Texas System | Method and apparatus for quantitative microimaging |
CA2769030C (en) | 2009-07-30 | 2016-05-10 | Tandem Diabetes Care, Inc. | Infusion pump system with disposable cartridge having pressure venting and pressure feedback |
AU2010308329B2 (en) | 2009-10-19 | 2016-10-13 | Labrador Diagnostics Llc | Integrated health data capture and analysis system |
JP5255553B2 (en) * | 2009-12-11 | 2013-08-07 | 株式会社日立ハイテクノロジーズ | Dispensing nozzle for automatic analyzer and automatic analyzer equipped with the same |
EP2531881A2 (en) | 2010-02-02 | 2012-12-12 | Pixtronix Inc. | Methods for manufacturing cold seal fluid-filled display apparatus |
KR101659642B1 (en) | 2010-02-02 | 2016-09-26 | 픽스트로닉스 인코포레이티드 | Circuits for controlling display apparatus |
US8965476B2 (en) | 2010-04-16 | 2015-02-24 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US20120016308A1 (en) | 2010-07-16 | 2012-01-19 | Seventh Sense Biosystems, Inc. | Low-pressure packaging for fluid devices |
US9662047B2 (en) | 2010-08-05 | 2017-05-30 | Massachusetts Institute Of Technology | Portable raman diagnostic system |
WO2012021801A2 (en) | 2010-08-13 | 2012-02-16 | Seventh Sense Biosystems, Inc. | Systems and techniques for monitoring subjects |
JP2012068159A (en) * | 2010-09-24 | 2012-04-05 | Hitachi High-Technologies Corp | Dispensing nozzle for autoanalyzer, autoanalyzer including the same, and method of manufacturing dispensing nozzle for autoanalyzer |
US8729502B1 (en) | 2010-10-28 | 2014-05-20 | The Research Foundation For The State University Of New York | Simultaneous, single-detector fluorescence detection of multiple analytes with frequency-specific lock-in detection |
ES2565805T3 (en) | 2010-11-09 | 2016-04-07 | Seventh Sense Biosystems, Inc. | Systems and interfaces for blood sampling |
US9451913B2 (en) | 2010-12-10 | 2016-09-27 | Touchtek Labs, Llc | Transdermal sampling and analysis device |
US9877673B2 (en) | 2010-12-10 | 2018-01-30 | Clinitech, Llc | Transdermal sampling and analysis device |
US9302908B2 (en) | 2010-12-17 | 2016-04-05 | Georgetown University | Systems and process for forming carbon nanotube sensors |
TWI690594B (en) | 2011-01-21 | 2020-04-11 | 美商賽瑞諾斯Ip有限責任公司 | Systems and methods for sample use maximization |
US20120215098A1 (en) * | 2011-02-22 | 2012-08-23 | John F Black | Trans-Catheter / Trans-Endoscope Drug and Stem Cell Delivery |
US9138172B2 (en) * | 2011-02-24 | 2015-09-22 | Rochester Institute Of Technology | Method for monitoring exposure to an event and device thereof |
US10244981B2 (en) | 2011-03-30 | 2019-04-02 | SensiVida Medical Technologies, Inc. | Skin test image analysis apparatuses and methods thereof |
EP2701598A1 (en) | 2011-04-29 | 2014-03-05 | Seventh Sense Biosystems, Inc. | Systems and methods for collecting fluid from a subject |
JP2014516644A (en) | 2011-04-29 | 2014-07-17 | セブンス センス バイオシステムズ,インコーポレーテッド | Devices and methods for collection and / or manipulation of blood spots or other body fluids |
US20130158468A1 (en) | 2011-12-19 | 2013-06-20 | Seventh Sense Biosystems, Inc. | Delivering and/or receiving material with respect to a subject surface |
KR102013466B1 (en) | 2011-04-29 | 2019-08-22 | 세븐쓰 센스 바이오시스템즈, 인크. | Delivering and/or receiving fluids |
CA2841785A1 (en) | 2011-07-06 | 2013-01-10 | The Parkinson's Institute | Compositions and methods for treatment of symptoms in parkinson's disease patients |
US20130041266A1 (en) * | 2011-08-12 | 2013-02-14 | Tyco Healthcare Group Lp, | System and Method for Indicating Positioning of an Internal Anatomical Feature |
US8723640B2 (en) | 2011-08-16 | 2014-05-13 | Elwha Llc | Distillation of status data relating to regimen compliance responsive to the presence and absence of wireless signals relating to one or more threshold frequencies |
US8934954B2 (en) | 2011-08-23 | 2015-01-13 | Impeto Medical | Assessment of sudomor function for peripheral diabetic neuropathy evaluation |
FR2982758B1 (en) | 2011-11-21 | 2013-11-15 | Impeto Medical | PHYSIOLOGICAL ANALYSIS METHOD OF INCREASED RELIABILITY |
US9968284B2 (en) | 2011-12-02 | 2018-05-15 | Clinitech, Llc | Anti-interferent barrier layers for non-invasive transdermal sampling and analysis device |
WO2013112877A1 (en) | 2012-01-25 | 2013-08-01 | Tasso, Inc. | Handheld device for drawing, collecting, and analyzing bodily fluid |
US9558590B2 (en) | 2012-03-28 | 2017-01-31 | Microsoft Technology Licensing, Llc | Augmented reality light guide display |
EP3539478A1 (en) | 2012-04-04 | 2019-09-18 | University of Cincinnati | Sweat simulation, collection and sensing systems |
US9717981B2 (en) | 2012-04-05 | 2017-08-01 | Microsoft Technology Licensing, Llc | Augmented reality and physical games |
US9681836B2 (en) | 2012-04-23 | 2017-06-20 | Cyberonics, Inc. | Methods, systems and apparatuses for detecting seizure and non-seizure states |
WO2013165474A1 (en) * | 2012-04-30 | 2013-11-07 | Yingchang Yang | Continuously wearable non-invasive apparatus for detecting abnormal health conditions |
US20140121485A2 (en) * | 2012-04-30 | 2014-05-01 | Georgetown University | Electrochemical Transdermal Glucose Measurement System Including Microheaters and Process For Forming |
US20150057513A1 (en) * | 2012-05-14 | 2015-02-26 | Arizona Board Of Regents On Behalf Of Arizona State University | Minimally Invasive Stress Sensors and Methods |
US9180242B2 (en) | 2012-05-17 | 2015-11-10 | Tandem Diabetes Care, Inc. | Methods and devices for multiple fluid transfer |
US10502876B2 (en) | 2012-05-22 | 2019-12-10 | Microsoft Technology Licensing, Llc | Waveguide optics focus elements |
WO2014011740A1 (en) * | 2012-07-10 | 2014-01-16 | Becton Dickinson France S.A.S. | Integrated injection system and communication device |
FR2994821B1 (en) | 2012-08-28 | 2014-08-29 | Impeto Medical | IMPROVED ELECTROPHYSIOLOGICAL ANALYSIS SYSTEM |
US9865176B2 (en) | 2012-12-07 | 2018-01-09 | Koninklijke Philips N.V. | Health monitoring system |
WO2014100259A1 (en) * | 2012-12-18 | 2014-06-26 | Abbott Cardiovascular Systems Inc. | Piezoelectric medical implant |
US8803296B2 (en) | 2012-12-18 | 2014-08-12 | Texas Instruments Incorporated | Coatings for relatively movable surfaces |
US10105487B2 (en) | 2013-01-24 | 2018-10-23 | Chrono Therapeutics Inc. | Optimized bio-synchronous bioactive agent delivery system |
US9134552B2 (en) | 2013-03-13 | 2015-09-15 | Pixtronix, Inc. | Display apparatus with narrow gap electrostatic actuators |
US9173998B2 (en) | 2013-03-14 | 2015-11-03 | Tandem Diabetes Care, Inc. | System and method for detecting occlusions in an infusion pump |
US10898116B2 (en) | 2013-03-15 | 2021-01-26 | Cambridge Medical Technologies LLC | Methods of manufacture to optimize performance of transdermal sampling and analysis device |
WO2014149161A2 (en) * | 2013-03-15 | 2014-09-25 | Georgetown University | Microfluidic systems for electrochemical transdermal glucose sensing using a paper-based or other wicking substrate |
US10004434B1 (en) * | 2013-03-15 | 2018-06-26 | Georgetown University | Microfluidic systems for electrochemical transdermal analyte sensing using a capillary-located electrode |
JP6105719B2 (en) | 2013-05-02 | 2017-03-29 | アトナープ株式会社 | Monitor and system for monitoring living body |
DE102013208825B4 (en) * | 2013-05-14 | 2021-05-20 | Robert Bosch Gmbh | Microstructure component and method for manufacturing a microstructure component |
US9811641B2 (en) | 2013-08-23 | 2017-11-07 | Elwha Llc | Modifying a cosmetic product based on a microbe profile |
US9390312B2 (en) | 2013-08-23 | 2016-07-12 | Elwha Llc | Systems, methods, and devices for assessing microbiota of skin |
WO2015027055A1 (en) * | 2013-08-23 | 2015-02-26 | Elwha Llc | Systems, methods, and devices for delivering treatment to a skin surface |
US20150057574A1 (en) * | 2013-08-23 | 2015-02-26 | Elwha Llc | Selecting and Delivering Treatment Agents based on a Microbe Profile |
US10010704B2 (en) | 2013-08-23 | 2018-07-03 | Elwha Llc | Systems, methods, and devices for delivering treatment to a skin surface |
US9805171B2 (en) | 2013-08-23 | 2017-10-31 | Elwha Llc | Modifying a cosmetic product based on a microbe profile |
US9456777B2 (en) | 2013-08-23 | 2016-10-04 | Elwha Llc | Systems, methods, and devices for assessing microbiota of skin |
US9526480B2 (en) | 2013-11-27 | 2016-12-27 | Elwha Llc | Devices and methods for profiling microbiota of skin |
US10152529B2 (en) | 2013-08-23 | 2018-12-11 | Elwha Llc | Systems and methods for generating a treatment map |
US9549703B2 (en) | 2013-11-27 | 2017-01-24 | Elwha Llc | Devices and methods for sampling and profiling microbiota of skin |
US9557331B2 (en) | 2013-08-23 | 2017-01-31 | Elwha Llc | Systems, methods, and devices for assessing microbiota of skin |
US8895340B1 (en) | 2013-09-10 | 2014-11-25 | Georgetown University | Biosensor and system and process for forming |
US10136831B2 (en) | 2013-10-18 | 2018-11-27 | University Of Cincinnati | Sweat sensing with chronological assurance |
US10182795B2 (en) | 2013-10-18 | 2019-01-22 | University Of Cincinnati | Devices for integrated, repeated, prolonged, and/or reliable sweat stimulation and biosensing |
US10888244B2 (en) | 2013-10-18 | 2021-01-12 | University Of Cincinnati | Sweat sensing with chronological assurance |
US9186278B2 (en) | 2013-11-27 | 2015-11-17 | Elwha Llc | Systems and devices for sampling and profiling microbiota of skin |
US9610037B2 (en) | 2013-11-27 | 2017-04-04 | Elwha Llc | Systems and devices for profiling microbiota of skin |
US9526450B2 (en) | 2013-11-27 | 2016-12-27 | Elwha Llc | Devices and methods for profiling microbiota of skin |
US10932761B2 (en) | 2014-05-28 | 2021-03-02 | University Of Cincinnati | Advanced sweat sensor adhesion, sealing, and fluidic strategies |
US10639015B2 (en) | 2014-05-28 | 2020-05-05 | University Of Cincinnati | Devices with reduced sweat volumes between sensors and sweat glands |
WO2015184084A2 (en) * | 2014-05-28 | 2015-12-03 | University Of Cincinnati | Sweat monitoring and control of drug delivery |
EP3174463B1 (en) | 2014-08-01 | 2020-07-29 | Tasso, Inc. | Systems for gravity-enhanced microfluidic collection, handling and transferring of fluids |
US10736551B2 (en) | 2014-08-11 | 2020-08-11 | The Board Of Trustees Of The University Of Illinois | Epidermal photonic systems and methods |
EP3179902B1 (en) | 2014-08-11 | 2020-10-14 | The Board of Trustees of the University of Illionis | Epidermal device for analysis of temperature and thermal transport characteristics |
EP3179899B1 (en) * | 2014-08-11 | 2023-10-04 | The Board of Trustees of the University of Illinois | Devices and related methods for epidermal characterization of biofluids |
US9788776B1 (en) | 2014-09-22 | 2017-10-17 | Verily Life Sciences Llc | Protein M-based in vivo diagnostic system and detection method |
CN107205643B (en) | 2014-09-22 | 2021-11-23 | 辛辛那提大学 | Sweat sensing with analytical assurance |
US9927442B1 (en) | 2014-10-31 | 2018-03-27 | Verily Life Sciences Llc | Biosensor for in vitro detection system and method of use |
FR3028744A1 (en) | 2014-11-25 | 2016-05-27 | Impeto Medical | ELECTROPHYSIOLOGICAL DATA COLLECTION DEVICE WITH INCREASED RELIABILITY |
US10213586B2 (en) | 2015-01-28 | 2019-02-26 | Chrono Therapeutics Inc. | Drug delivery methods and systems |
EP3256049A4 (en) | 2015-02-13 | 2018-07-25 | University of Cincinnati | Devices for integrated indirect sweat stimulation and sensing |
GB201502447D0 (en) | 2015-02-13 | 2015-04-01 | Univ Liverpool | Method and apparatus for sample analysis |
AU2016228779A1 (en) | 2015-03-12 | 2017-09-07 | Chrono Therapeutics Inc. | Craving input and support system |
US10646142B2 (en) | 2015-06-29 | 2020-05-12 | Eccrine Systems, Inc. | Smart sweat stimulation and sensing devices |
US11219390B2 (en) | 2015-08-03 | 2022-01-11 | Georgetown University | Apparatus and method for delivery of antimicrobial during a transdermal sampling and delivery process |
EP3364862A4 (en) | 2015-10-23 | 2019-10-23 | Eccrine Systems, Inc. | Devices capable of sample concentration for extended sensing of sweat analytes |
US10674946B2 (en) | 2015-12-18 | 2020-06-09 | Eccrine Systems, Inc. | Sweat sensing devices with sensor abrasion protection |
CN114209315A (en) | 2015-12-21 | 2022-03-22 | 塔索公司 | Devices, systems, and methods for actuation and retraction in fluid collection |
US10746663B2 (en) * | 2016-02-26 | 2020-08-18 | DermaTec LLC | Methods and apparatuses relating to dermal biochemical sensors |
US10471249B2 (en) | 2016-06-08 | 2019-11-12 | University Of Cincinnati | Enhanced analyte access through epithelial tissue |
WO2017218878A1 (en) | 2016-06-17 | 2017-12-21 | The Board Of Trustees Of The University Of Illinois | Soft, wearable microfluidic systems capable of capture, storage, and sensing of biofluids |
EP3478186A4 (en) | 2016-07-01 | 2020-03-04 | University of Cincinnati | Devices with reduced microfluidic volume between sensors and sweat glands |
JP2019528174A (en) | 2016-07-06 | 2019-10-10 | プレシジョン ナノシステムズ インコーポレーテッドPrecision Nanosystems Inc | Smart microfluidic mixing device and cartridge |
US11832801B2 (en) * | 2016-07-11 | 2023-12-05 | Arizona Board Of Regents On Behalf Of Arizona State University | Sweat as a biofluid for analysis and disease identification |
EP3487390A4 (en) | 2016-07-19 | 2020-03-11 | Eccrine Systems, Inc. | Sweat conductivity, volumetric sweat rate and galvanic skin response devices and applications |
US10736565B2 (en) | 2016-10-14 | 2020-08-11 | Eccrine Systems, Inc. | Sweat electrolyte loss monitoring devices |
US10653349B2 (en) * | 2016-10-18 | 2020-05-19 | International Business Machines Corporation | Diagnostic apparatus |
US11534090B2 (en) | 2016-10-28 | 2022-12-27 | Georgetown University | Non-invasive passive interstitial fluid collector |
AU2018205529B2 (en) | 2017-01-06 | 2023-08-10 | Morningside Venture Investments Limited | Transdermal drug delivery devices and methods |
WO2018144506A1 (en) * | 2017-01-31 | 2018-08-09 | Georgetown University | Harvesting cell-free non-coding rnas (cfncrs) from interstitial fluid for sensitive biomarkers |
WO2018194660A1 (en) * | 2017-04-21 | 2018-10-25 | Hewlett-Packard Development Company, L.P. | Health assessment cards |
KR102411603B1 (en) * | 2017-06-02 | 2022-06-21 | 노오쓰웨스턴 유니버시티 | Microfluidic Systems for Epidermal Sampling and Detection |
EP3700408A1 (en) * | 2017-10-25 | 2020-09-02 | Skindicator AB | A device and a method for detection of changes in tissue |
CA3101966A1 (en) | 2018-05-29 | 2019-12-05 | Morningside Venture Investments Limited | Drug delivery methods and systems |
EP3820368B1 (en) | 2018-09-14 | 2023-08-09 | Tasso, Inc. | Bodily fluid collection device |
WO2020102277A1 (en) * | 2018-11-13 | 2020-05-22 | University Of Cincinnati | Quality assurance of collected interstitial fluid samples |
BR112021009861A2 (en) * | 2018-11-21 | 2021-08-31 | Acies Medical Llc | DETECTION SYSTEMS AND METHODS FOR MEDICAL DEVICES |
US11464908B2 (en) | 2019-02-18 | 2022-10-11 | Tandem Diabetes Care, Inc. | Methods and apparatus for monitoring infusion sites for ambulatory infusion pumps |
US11633129B2 (en) | 2019-04-05 | 2023-04-25 | Cambridge Medical Technologies LLC | Non-invasive transdermal sampling and analysis device incorporating redox cofactors |
US11375931B2 (en) | 2019-08-08 | 2022-07-05 | Cambridge Medical Technologies LLC | Non-invasive transdermal sampling and analysis device incorporating an electrochemical bioassay |
Family Cites Families (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4526176A (en) * | 1981-12-22 | 1985-07-02 | Frantz Medical Development Ltd. | Long-life biomedical application device, particularly electrode, and method of transferring electrical current |
US4708716A (en) | 1983-08-18 | 1987-11-24 | Drug Delivery Systems Inc. | Transdermal drug applicator |
US4909256A (en) * | 1985-02-11 | 1990-03-20 | The United States Of America, As Represented By The Secretary Of The Army | Transdermal vapor collection method and apparatus |
US4775361A (en) | 1986-04-10 | 1988-10-04 | The General Hospital Corporation | Controlled removal of human stratum corneum by pulsed laser to enhance percutaneous transport |
US4821733A (en) * | 1987-08-18 | 1989-04-18 | Dermal Systems International | Transdermal detection system |
ATE74438T1 (en) * | 1987-09-04 | 1992-04-15 | Moeller Willi Ag | ION-SELECTIVE PART OF DEVICES FOR DETERMINING THE ION CONCENTRATIONS AND METHODS FOR THE PRODUCTION OF POLYMER MATERIALS HAVING HYDROPHILIC GROUPS. |
US5362307A (en) | 1989-01-24 | 1994-11-08 | The Regents Of The University Of California | Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance |
US5330527A (en) * | 1988-03-25 | 1994-07-19 | Lec Tec Corporation | Multipurpose medical electrode |
US5078134A (en) * | 1988-04-25 | 1992-01-07 | Lifecor, Inc. | Portable device for sensing cardiac function and automatically delivering electrical therapy |
US5203327A (en) * | 1988-09-08 | 1993-04-20 | Sudor Partners | Method and apparatus for determination of chemical species in body fluid |
DE3831141A1 (en) | 1988-09-13 | 1990-03-22 | Zeiss Carl Fa | METHOD AND DEVICE FOR MICROSURGERY ON EYE BY LASER RADIATION |
US5176881A (en) * | 1989-08-11 | 1993-01-05 | The University Of Tennessee Research Corporation | Fiber optic-based regenerable biosensor |
JP3189337B2 (en) * | 1991-11-08 | 2001-07-16 | 日本電気株式会社 | Skin stratum corneum removal device and method |
JPH05172815A (en) * | 1991-12-26 | 1993-07-13 | Hitachi Ltd | Immunity analyzing method and analyzing device therefor |
US5380272A (en) * | 1993-01-28 | 1995-01-10 | Scientific Innovations Ltd. | Transcutaneous drug delivery applicator |
US6251100B1 (en) * | 1993-09-24 | 2001-06-26 | Transmedica International, Inc. | Laser assisted topical anesthetic permeation |
US5885211A (en) * | 1993-11-15 | 1999-03-23 | Spectrix, Inc. | Microporation of human skin for monitoring the concentration of an analyte |
US5458140A (en) | 1993-11-15 | 1995-10-17 | Non-Invasive Monitoring Company (Nimco) | Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers |
US5591139A (en) * | 1994-06-06 | 1997-01-07 | The Regents Of The University Of California | IC-processed microneedles |
JP2636797B2 (en) * | 1995-05-24 | 1997-07-30 | 日本電気株式会社 | Suction leachate collection device |
JP2718408B2 (en) * | 1995-09-20 | 1998-02-25 | 日本電気株式会社 | Leachate suction device |
US5801057A (en) * | 1996-03-22 | 1998-09-01 | Smart; Wilson H. | Microsampling device and method of construction |
AU3070397A (en) * | 1996-05-17 | 1997-12-05 | Mercury Diagnostics Inc. | Methods and apparatus for sampling body fluid |
US6120460A (en) * | 1996-09-04 | 2000-09-19 | Abreu; Marcio Marc | Method and apparatus for signal acquisition, processing and transmission for evaluation of bodily functions |
US7220550B2 (en) | 1997-05-14 | 2007-05-22 | Keensense, Inc. | Molecular wire injection sensors |
US6124597A (en) * | 1997-07-07 | 2000-09-26 | Cedars-Sinai Medical Center | Method and devices for laser induced fluorescence attenuation spectroscopy |
KR19990011177A (en) * | 1997-07-22 | 1999-02-18 | 김해운 | Manufacturing method of index pocket |
CN1058817C (en) | 1998-01-21 | 2000-11-22 | 广东省经济特区实业有限公司 | Quasi-stationary current and voltage controlled AC load arrangement |
WO1999044507A1 (en) * | 1998-03-06 | 1999-09-10 | Spectrx, Inc. | Integrated tissue poration, fluid harvesting and analysis device, and method therefor |
CA2265119C (en) | 1998-03-13 | 2002-12-03 | Cygnus, Inc. | Biosensor, iontophoretic sampling system, and methods of use thereof |
DK1053043T3 (en) * | 1998-05-13 | 2002-11-18 | Cygnus Therapeutic Systems | Collection units for transdermal sampling systems |
DK1077636T3 (en) * | 1998-05-13 | 2004-05-24 | Cygnus Therapeutic Systems | Signal processing for measurement of physiological analytes |
US7344499B1 (en) * | 1998-06-10 | 2008-03-18 | Georgia Tech Research Corporation | Microneedle device for extraction and sensing of bodily fluids |
JP2004510453A (en) * | 1998-07-21 | 2004-04-08 | スペクトルクス,インコーポレイティド | Systems and methods for continuous analyte monitoring |
JP4531983B2 (en) * | 1998-09-10 | 2010-08-25 | アルテア セラピューティクス コーポレイション | Attribute compensation for analyte detection and / or continuous monitoring |
US6464687B1 (en) * | 1999-03-09 | 2002-10-15 | Ball Semiconductor, Inc. | Implantable drug delivery system |
US6887202B2 (en) | 2000-06-01 | 2005-05-03 | Science Applications International Corporation | Systems and methods for monitoring health and delivering drugs transdermally |
US6730212B1 (en) | 2000-10-03 | 2004-05-04 | Hrl Laboratories, Llc | Sensor for chemical and biological materials |
US7655477B1 (en) | 2003-02-26 | 2010-02-02 | Science Applications International Corporation | System and method for the separation of analytes |
US7888509B2 (en) | 2003-10-30 | 2011-02-15 | Georgetown University | Chiral 1,8-diarylnaphthalenes, methods of making them, and their use as sensors |
US8333874B2 (en) | 2005-12-09 | 2012-12-18 | Flexible Medical Systems, Llc | Flexible apparatus and method for monitoring and delivery |
EP2232249A4 (en) | 2007-12-13 | 2014-04-16 | Univ Monash | Electrochemical nanocomposite biosensor system |
-
2001
- 2001-05-30 US US09/866,826 patent/US6887202B2/en not_active Expired - Lifetime
- 2001-05-30 AU AU2001265012A patent/AU2001265012B2/en not_active Expired
- 2001-05-30 CA CA2843053A patent/CA2843053C/en not_active Expired - Lifetime
- 2001-05-30 JP JP2001587645A patent/JP5180418B2/en not_active Expired - Lifetime
- 2001-05-30 WO PCT/US2001/017081 patent/WO2001091626A2/en active Search and Examination
- 2001-05-30 AU AU6501201A patent/AU6501201A/en active Pending
- 2001-05-30 CA CA002409826A patent/CA2409826C/en not_active Expired - Lifetime
- 2001-05-30 CA CA2688795A patent/CA2688795C/en not_active Expired - Lifetime
- 2001-05-30 EP EP01939501.1A patent/EP1585423B1/en not_active Expired - Lifetime
-
2005
- 2005-03-28 US US11/090,156 patent/US7931592B2/en active Active
-
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- 2006-10-03 AU AU2006225209A patent/AU2006225209B8/en not_active Expired
-
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- 2010-03-10 AU AU2010200890A patent/AU2010200890C1/en not_active Expired
-
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- 2011-04-13 US US13/085,775 patent/US8568315B2/en not_active Expired - Lifetime
- 2011-07-06 JP JP2011150236A patent/JP5069366B2/en not_active Expired - Lifetime
-
2012
- 2012-12-17 JP JP2012274380A patent/JP2013056209A/en active Pending
-
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- 2013-06-03 JP JP2013117007A patent/JP2013166032A/en active Pending
- 2013-09-25 US US14/036,966 patent/US9332937B2/en not_active Expired - Lifetime
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2444980C2 (en) * | 2007-03-07 | 2012-03-20 | Эко Терапьютикс, Инк. | Transdermal system of analite monitoring and methods of analite detection |
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WO2001091626A3 (en) | 2009-03-19 |
JP2013166032A (en) | 2013-08-29 |
AU2010200890A1 (en) | 2010-04-01 |
AU6501201A (en) | 2001-12-11 |
CA2688795C (en) | 2014-07-08 |
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AU2010200890C1 (en) | 2011-09-01 |
JP2004522460A (en) | 2004-07-29 |
US7931592B2 (en) | 2011-04-26 |
CA2843053A1 (en) | 2001-12-06 |
EP1585423B1 (en) | 2016-08-17 |
JP5069366B2 (en) | 2012-11-07 |
AU2006225209B2 (en) | 2009-12-10 |
US20030225362A1 (en) | 2003-12-04 |
JP5180418B2 (en) | 2013-04-10 |
WO2001091626A2 (en) | 2001-12-06 |
EP1585423A4 (en) | 2011-02-16 |
US6887202B2 (en) | 2005-05-03 |
US20120010487A1 (en) | 2012-01-12 |
US9332937B2 (en) | 2016-05-10 |
CA2688795A1 (en) | 2001-12-06 |
CA2409826C (en) | 2010-02-02 |
EP1585423A2 (en) | 2005-10-19 |
JP2013056209A (en) | 2013-03-28 |
JP2011200702A (en) | 2011-10-13 |
AU2010200890B2 (en) | 2011-05-12 |
US8568315B2 (en) | 2013-10-29 |
US20140025000A1 (en) | 2014-01-23 |
AU2006225209A1 (en) | 2006-10-26 |
AU2006225209B8 (en) | 2010-04-01 |
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