CA2396698A1 - Tissue graft - Google Patents

Tissue graft Download PDF

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Publication number
CA2396698A1
CA2396698A1 CA002396698A CA2396698A CA2396698A1 CA 2396698 A1 CA2396698 A1 CA 2396698A1 CA 002396698 A CA002396698 A CA 002396698A CA 2396698 A CA2396698 A CA 2396698A CA 2396698 A1 CA2396698 A1 CA 2396698A1
Authority
CA
Canada
Prior art keywords
tissue
graft
matrix
defective
tissue matrix
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002396698A
Other languages
French (fr)
Other versions
CA2396698C (en
Inventor
Jeremy D. Ollerenshaw
Steven Goldstein
Kirby S. Black
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Artivion Inc
Original Assignee
Cryolife, Inc.
Jeremy D. Ollerenshaw
Steven Goldstein
Kirby S. Black
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cryolife, Inc., Jeremy D. Ollerenshaw, Steven Goldstein, Kirby S. Black filed Critical Cryolife, Inc.
Publication of CA2396698A1 publication Critical patent/CA2396698A1/en
Application granted granted Critical
Publication of CA2396698C publication Critical patent/CA2396698C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/005—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking

Abstract

The present invention relates to a method of preparing a tissue graft material. The invention also relates to a multipurpose tissue graft material and to methods of using same as a replacement for vascular and non-vascular tissue.

Claims (46)

WHAT IS CLAIMED IS
1. A method of preparing a tissue graft comprising:
1) washing a starting tissue obtained from a human or animal ureter with a bioburden reducing agent so that said starting tissue is disinfected, ii) decellularizing the disinfected tissue resulting from step (1) with a solution that lyses cells of said disinfected tissue so that a tissue matrix is formed, and iii) contacting said tissue matrix resulting from step (ii) with a nuclease so that nucleic acid associated with said tissue matrix is degraded, and iv) washing said tissue matrix resulting from (iii) so that cellular or extracellular debris is removed and said tissue graft is obtained.
2. The method according to claim 1 wherein said bioburden reducing agent is an antimicrobial agent.
3. The method according to claim 2 wherein the antimicrobial agent comprises an antibiotic.
4. The method according to claim 1 wherein said solution that lyses said cells comprises sterile water.
5. The method according to claim 1 wherein said solution that lyses said cells comprises an aqueous hypotonic buffer or low ionic strength buffer.
6. The method according to claim 1 wherein said nuclease comprises an exonuclease an d an endonuclease.
7. The method according to claim 6 wherein said nuclease comprises DNAse I and RNAse A.
8. The method according to claim 7 wherein step (iii) comprises contacting said tissue matrix with said nuclease at 20°C to 38°C for 1 to 36 hours.
9. The method according to claim 1 further comprising, after step (iv), sterilizing said tissue matrix.
10. The method according to claim 9 wherein said sterilization is effected using gamma irradiation, iodine, peracetic acid or electron beam.
11. The method according to claim 10 wherein said sterilization is effected using gamma irradiation.
12. The method according to claim 10 wherein said tissue matrix is maintained at a temperature between 2°C and 8°C during said sterilization.
13. The method according to claim 1 further comprising, after step (iv), cryopreserving said tissue matrix.
14. A tissue graft obtainable by the method according to claim 1.
15. A method of treating a patient having a defective tissue comprising replacing said defective tissue with an unfixed, decellularized tissue graft that is obtainable by the method according to claim 1.
16. The method according to claim 15 wherein said defective tissue has a tubular structure.
17. The method according to claim 15 wherein said tissue graft has a tubular structure.
28. The method according to claim 17 wherein said tissue graft is a vascular graft, a ureter graft or a nerve guide.
19. The method according to claim 15 wherein said tissue graft is a patch.
20. The method according to claim 19 wherein said defective tissue is skin.
21. A method of preparing a tissue graft comprising:
i) washing a starting tissue obtained from a human or animal source with a bioburden reducing agent so that said starting tissue is disinfected, ii) decellularizing the disinfected tissue resulting from step (i) with a solution that lyses cells of said disinfected tissue so that a tissue matrix is formed, iii) contacting said tissue matrix resulting from step (ii) with a nuclease so that nucleic acid associated with said tissue matrix is degraded, iv) washing said tissue matrix resulting from (iii) so that cellular or extracellular debris is removed and said tissue graft is obtained, and v) sterilizing said tissue matrix resulting from (iv) while maintaining said tissue matrix in a non-frozen state at a temperature between 0°C and 40°C.
22. The method according to claim 21 wherein the starting tissue is ureter, vein, artery, tendon, heart valve, fascia lata, pericardium or nerve.
23. The method according to claim 22 wherein said starting tissue is ureter.
24. The method according to claim 21 wherein said bioburden reducing agent is an antimicrobial agent.
25. The method according to claim 24 wherein the antimicrobial agent comprises an antibiotic.
26. The method according to claim 21 wherein, in step (v), said temperature is maintained between 2°C and 8°C.
27. The method according to claim 21 wherein said solution that lyses said cells comprises sterile water.
28. The method according to claim 21 wherein said solution that lyses said cells comprises an aqueous hypotonic buffer or low ionic strength buffer.
29. The method according to claim 21 wherein said solution that lyses said cells comprises a protease inhibitor.
30. The method according to claim 21 wherein said nuclease comprises an excnuclease and an endonuclease.
31. The method according to claim 30 wherein said nuclease comprises DNAse I and RNAse A.
32. The method according to claim 31 wherein step (iii) comprises contacting said tissue matrix with said nuclease at 20°C to 38°C
for 1 to 36 hours.
33. The method according to claim 2i wherein step (iv) comprises washing said tissue matrix at 2°C to 42°C for up to 7 days.
34. The method according to claim 21 wherein said sterilization is effected using gamma irradiation, iodine, peracetic acid or electron beam.
35. The method according to claim 34 wherein said sterilization is effected using gamma irradiation.
36. The method according to claim 21 further comprising, after step (iv) and before step (v), or after step (v), cryopreserving said tissue matrix.
37. The method according to claim 21 wherein, after step (v), said tissue matrix is maintained at about 25°C prior to implantation.
38. A tissue graft obtainable by the method according to claim 21.
39. The tissue graft according to claim 38 wherein the starting tissue is ureter.
40. A method of treating a patient having a defective tissue comprising replacing said defective tissue with an unfixed decellularized tissue graft that is obtainable by the method according to claim 21.
41. The method according to claim 40 wherein said defective tissue has a tubular structure.
42. The method according to claim 40 wherein said defective tissue has a tubular structure.
43. The method according to claim 40 wherein said tissue grain has a tubular structure.
44. The method according to claim 43 wherein said tissue graft is a vascular graft, a ureter graft or a nerve guide.
45. The method according to claim 40 wherein said tissue graft is a patch.
46. The method according to claim 45 wherein said defective tissue is skin.
CA2396698A 2000-01-28 2001-01-29 Tissue graft Expired - Fee Related CA2396698C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US17863200P 2000-01-28 2000-01-28
US60/178,632 2000-01-28
US09/769,769 US6866686B2 (en) 2000-01-28 2001-01-26 Tissue graft
US09/769,769 2001-01-26
PCT/US2001/002793 WO2001054619A1 (en) 2000-01-28 2001-01-29 Tissue graft

Publications (2)

Publication Number Publication Date
CA2396698A1 true CA2396698A1 (en) 2001-08-02
CA2396698C CA2396698C (en) 2010-11-02

Family

ID=26874499

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2396698A Expired - Fee Related CA2396698C (en) 2000-01-28 2001-01-29 Tissue graft

Country Status (12)

Country Link
US (3) US6866686B2 (en)
EP (2) EP1591078B1 (en)
JP (1) JP5142437B2 (en)
AU (1) AU783780B2 (en)
CA (1) CA2396698C (en)
CY (1) CY1109458T1 (en)
DE (1) DE60139279D1 (en)
DK (1) DK1591078T3 (en)
ES (1) ES2329480T3 (en)
NO (1) NO327637B1 (en)
PT (1) PT1591078E (en)
WO (1) WO2001054619A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011132089A2 (en) * 2010-02-26 2011-10-27 Dalhousie University Methods for tissue decellularization
US10307510B2 (en) 2013-11-04 2019-06-04 Lifecell Corporation Methods of removing alpha-galactose

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU732726B2 (en) * 1996-12-10 2001-04-26 Purdue Research Foundation Biomaterial derived from vertebrate liver tissue
US6866686B2 (en) * 2000-01-28 2005-03-15 Cryolife, Inc. Tissue graft
CA2419817C (en) * 2000-08-16 2014-11-18 Duke University Decellularized tissue engineered constructs and tissues
US20030185702A1 (en) * 2002-02-01 2003-10-02 Wilson Burgess Methods for sterilizing tissue
US20110091353A1 (en) * 2001-09-24 2011-04-21 Wilson Burgess Methods for Sterilizing Tissue
US20030124023A1 (en) * 2001-12-21 2003-07-03 Wilson Burgess Method of sterilizing heart valves
WO2003059061A1 (en) * 2002-01-11 2003-07-24 Purdue Research Foundation Biomaterial derived from vertebrate liver tissue
US20030180181A1 (en) * 2002-02-01 2003-09-25 Teri Greib Methods for sterilizing tissue
US20030187515A1 (en) * 2002-03-26 2003-10-02 Hariri Robert J. Collagen biofabric and methods of preparing and using the collagen biofabric
US20050256588A1 (en) * 2002-06-28 2005-11-17 Cardio, Inc. Decellularized tissue
US20040187877A1 (en) * 2002-12-04 2004-09-30 Badylak Stephen F. Method for repair of liver tissue
US20040191226A1 (en) * 2002-12-04 2004-09-30 Badylak Stephen F. Method for repair of body wall
US20040161362A1 (en) * 2002-12-27 2004-08-19 Bogert David L. Audible range acoustic cleaning process for implants
EP1698356A4 (en) * 2003-12-26 2007-03-14 Cardio Inc Decellularized tissue and method of preparing the same
WO2006095342A2 (en) 2005-03-07 2006-09-14 Technion Research & Development Foundation Ltd. Natural tissue-derived decellularized matrix and methods of generating and using same
AU2006265601A1 (en) * 2005-06-30 2007-01-11 Anthrogenesis Corporation Repair of tympanic membrane using placenta derived collagen biofabric
WO2007070301A2 (en) * 2005-12-05 2007-06-21 Regeneration Technologies, Inc. Vascular graft sterilization and decellularization
GB0606231D0 (en) 2006-03-29 2006-05-10 Univ Leeds Improvements relating to decellurisation of tissue matrices for bladder implantation
WO2007124127A2 (en) * 2006-04-21 2007-11-01 Wake Forest University Health Sciences Structurally modified acellular tissue engineering scaffolds and methods of production
KR20090031895A (en) * 2006-06-09 2009-03-30 안트로제네시스 코포레이션 Placental niche and use thereof to culture stem cells
WO2008021391A1 (en) * 2006-08-15 2008-02-21 Anthrogenesis Corporation Umbilical cord biomaterial for medical use
US20080131522A1 (en) * 2006-10-03 2008-06-05 Qing Liu Use of placental biomaterial for ocular surgery
US8071135B2 (en) 2006-10-04 2011-12-06 Anthrogenesis Corporation Placental tissue compositions
CN104623643A (en) 2006-10-06 2015-05-20 人类起源公司 Natural (telopeptide) placental collagen compositions
EP2113262B1 (en) 2008-04-29 2013-11-06 Proxy Biomedical Limited A Tissue Repair Implant
CN102271722B (en) * 2008-11-04 2015-03-04 坦吉恩股份有限公司 Cell-scaffold constructs
PT2352472T (en) * 2008-11-04 2017-04-11 Stratatech Corp Dried and irradiated skin equivalents for ready use
US9150318B1 (en) * 2009-01-02 2015-10-06 Lifecell Corporation Method for sterilizing an acellular tissue matrix
WO2010099310A1 (en) 2009-02-26 2010-09-02 Wake Forest University Health Sciences Endothelial scaffolds
WO2010101883A2 (en) * 2009-03-06 2010-09-10 Mayo Foundation For Medical Education And Research Tendon or ligament tissue engineering
EP2405742A2 (en) * 2009-03-11 2012-01-18 CryoLife, Inc. Bioburden-reducing antibiotic composition and method of use
US8906362B2 (en) 2009-03-23 2014-12-09 Wake Forest University Health Sciences Tissue engineered meniscus scaffolds and methods of use
WO2011068778A1 (en) * 2009-12-03 2011-06-09 Lifecell Corporation Nerve treatment devices and methods
JP2013165740A (en) * 2010-05-14 2013-08-29 Waseda Univ Decellularization method and artificial tissue for implantation into the human body
US8475827B2 (en) 2010-07-06 2013-07-02 Cryolife, Inc. Tissue implants for implantation and methods for preparing the same
US8377143B2 (en) 2010-07-06 2013-02-19 Cryolife, Inc. Tissue implants for implantation and methods for preparing the same
WO2012031233A2 (en) * 2010-09-03 2012-03-08 The General Hospital Corporation Blood vessel grafts for repair, reconstruction and filler materials
US9089523B2 (en) 2011-07-28 2015-07-28 Lifecell Corporation Natural tissue scaffolds as tissue fillers
ES2935163T3 (en) 2011-10-14 2023-03-02 Humacyte Inc tubular prostheses
CN104302329A (en) * 2012-03-31 2015-01-21 学校法人早稻田大学 Method for treating biological tissue and biological tissue
EP2869858B1 (en) * 2012-07-06 2019-02-27 LifeCell Corporation Decellularized muscle matrix
US10085946B2 (en) 2012-09-04 2018-10-02 Technion Research & Development Foundation Limited Use of decellularized extracellular matrix for encapsulating cells
EP3027235A1 (en) 2013-07-30 2016-06-08 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US9238090B1 (en) 2014-12-24 2016-01-19 Fettech, Llc Tissue-based compositions
US10912864B2 (en) 2015-07-24 2021-02-09 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
USD856517S1 (en) 2016-06-03 2019-08-13 Musculoskeletal Transplant Foundation Asymmetric tissue graft
US10945831B2 (en) 2016-06-03 2021-03-16 Musculoskeletal Transplant Foundation Asymmetric tissue graft
ES2841427T3 (en) 2016-07-05 2021-07-08 Lifecell Corp Tissue matrices incorporating multiple tissue types
JP2018033694A (en) * 2016-08-31 2018-03-08 新幹工業株式会社 Method of forming connective tissue body
EP3306347B1 (en) * 2016-10-10 2022-07-06 Trimble Inc. System and method for registration of survey points
CN107890586B (en) * 2017-10-27 2021-06-01 百澳瑞派（天津）生物科技有限公司 Preparation method of allogeneic biological breast patch
USD895812S1 (en) 2018-09-07 2020-09-08 Musculoskeletal Transplant Foundation Soft tissue repair graft
US10813743B2 (en) 2018-09-07 2020-10-27 Musculoskeletal Transplant Foundation Soft tissue repair grafts and processes for preparing and using same
US20200129309A1 (en) * 2018-10-30 2020-04-30 Surgentec, Llc Method and container for delivering bone graft material

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1358465A (en) * 1963-02-21 1964-04-17 Process for the treatment of animal tissues, in particular with a view to the separation of polysaccharides
US3551560A (en) * 1967-10-02 1970-12-29 Heinrich F Thiele Process of reconstructing tendons,cartilage,nerve sheaths,and products
US3927422A (en) 1973-12-12 1975-12-23 Philip Nicholas Sawyer Prosthesis and method for making same
US4082507A (en) 1976-05-10 1978-04-04 Sawyer Philip Nicholas Prosthesis and method for making the same
WO1982000091A1 (en) 1980-07-01 1982-01-21 V Ketharanathan Vascular prostheses
JPS58180162A (en) * 1982-04-19 1983-10-21 株式会社高研 Anti-thrombosis medical material
US4695281A (en) * 1983-03-25 1987-09-22 Koken Co., Ltd. Medical material
US4801299A (en) 1983-06-10 1989-01-31 University Patents, Inc. Body implants of extracellular matrix and means and methods of making and using such implants
US4657544A (en) * 1984-04-18 1987-04-14 Cordis Corporation Cardiovascular graft and method of forming same
US4759757A (en) * 1984-04-18 1988-07-26 Corvita Corporation Cardiovascular graft and method of forming same
US4755593A (en) * 1985-07-24 1988-07-05 Lauren Mark D Novel biomaterial of cross-linked peritoneal tissue
GB8618374D0 (en) 1986-07-28 1986-09-03 Hsc Res Dev Corp Biological vascular prostheses
ATE109491T1 (en) * 1988-03-11 1994-08-15 Chemokol G B R Ing Buero Fuer PROCESS FOR MANUFACTURING COLLAGEN MEMBRANES FOR HEMOSTASIS, WOUND TREATMENT AND IMPLANTS.
US4902508A (en) 1988-07-11 1990-02-20 Purdue Research Foundation Tissue graft composition
US5080198A (en) * 1990-02-06 1992-01-14 Rice Gene A Apparatus for greasing wheel bearings
US5209776A (en) * 1990-07-27 1993-05-11 The Trustees Of Columbia University In The City Of New York Tissue bonding and sealing composition and method of using the same
US5336616A (en) 1990-09-12 1994-08-09 Lifecell Corporation Method for processing and preserving collagen-based tissues for transplantation
US5632776A (en) * 1990-11-22 1997-05-27 Toray Industries, Inc. Implantation materials
US5690675A (en) * 1991-02-13 1997-11-25 Fusion Medical Technologies, Inc. Methods for sealing of staples and other fasteners in tissue
EP0571527B1 (en) * 1991-02-14 1996-04-24 Baxter International Inc. Method of manufacturing pliable biological graft materials
US5192312A (en) 1991-03-05 1993-03-09 Colorado State University Research Foundation Treated tissue for implantation and methods of treatment and use
DE69326631T2 (en) 1992-03-19 2000-06-08 Medtronic Inc Intraluminal expansion device
US5523291A (en) * 1993-09-07 1996-06-04 Datascope Investment Corp. Injectable compositions for soft tissue augmentation
US5460962A (en) * 1994-01-04 1995-10-24 Organogenesis Inc. Peracetic acid sterilization of collagen or collagenous tissue
EP1452153A1 (en) 1994-03-14 2004-09-01 Cryolife, Inc Treated tissue for implantation and preparation methods
US5595571A (en) 1994-04-18 1997-01-21 Hancock Jaffe Laboratories Biological material pre-fixation treatment
US5716394A (en) * 1994-04-29 1998-02-10 W. L. Gore & Associates, Inc. Blood contact surfaces using extracellular matrix synthesized in vitro
EP0757564A1 (en) * 1994-04-29 1997-02-12 Gore Hybrid Technologies, Inc. Improved blood contact surfaces employing natural subendothelial matrix and method for making and using the same
FR2728898B1 (en) * 1994-12-29 1997-01-31 Rhone Poulenc Chimie PROCESS FOR THE PREPARATION OF CARBOXYLIC ACIDS BY HOUSEHOLD OXIDATION OF THE CORRESPONDING ALKANES
US6039755A (en) 1997-02-05 2000-03-21 Impra, Inc., A Division Of C.R. Bard, Inc. Radially expandable tubular polytetrafluoroethylene grafts and method of making same
DE69622548T2 (en) * 1995-04-07 2003-09-18 Purdue Research Foundation West Lafayette TISSUE TRANSPLANT FOR BUBBLE RECONSTRUCTION
EP0821573A4 (en) 1995-04-19 2000-08-09 St Jude Medical Matrix substrate for a viable body tissue-derived prosthesis and method for making the same
US5657544A (en) * 1995-09-26 1997-08-19 Ntn Corporation Device for detecting the angle of rotation
JPH09122227A (en) * 1995-10-31 1997-05-13 Bio Eng Lab:Kk Medical material and manufacture thereof
US5607478A (en) 1996-03-14 1997-03-04 Meadox Medicals Inc. Yarn wrapped PTFE tubular prosthesis
US5755791A (en) * 1996-04-05 1998-05-26 Purdue Research Foundation Perforated submucosal tissue graft constructs
US6010529A (en) 1996-12-03 2000-01-04 Atrium Medical Corporation Expandable shielded vessel support
JP2001505807A (en) * 1996-12-10 2001-05-08 パーデュー・リサーチ・ファウンデーション Artificial vascular valve
WO1998036707A1 (en) 1997-02-07 1998-08-27 Sisters Of Providence In Oregon Method of producing biomaterials
US6048360A (en) 1997-03-18 2000-04-11 Endotex Interventional Systems, Inc. Methods of making and using coiled sheet graft for single and bifurcated lumens
WO1998046165A1 (en) * 1997-04-11 1998-10-22 Cryolife, Inc. Tissue decellularization
US6206917B1 (en) 1997-05-02 2001-03-27 St. Jude Medical, Inc. Differential treatment of prosthetic devices
US5993844A (en) 1997-05-08 1999-11-30 Organogenesis, Inc. Chemical treatment, without detergents or enzymes, of tissue to form an acellular, collagenous matrix
US6371992B1 (en) * 1997-12-19 2002-04-16 The Regents Of The University Of California Acellular matrix grafts: preparation and use
ES2166220T3 (en) * 1998-06-25 2002-04-01 Vascular Biotech Gmbh EPITELIALIZATION OR ENDOTHELIALIZATION AUTOLOGY OF HOLLOW OR VESSEL ORGANS.
US20100030340A1 (en) * 1998-06-30 2010-02-04 Wolfinbarger Jr Lloyd Plasticized Grafts and Methods of Making and Using Same
US6866686B2 (en) 2000-01-28 2005-03-15 Cryolife, Inc. Tissue graft
AUPR217300A0 (en) * 2000-12-20 2001-01-25 Ketharanathan, Vettivetpillai Method of creating biological and biosynthetic material for implantation

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011132089A2 (en) * 2010-02-26 2011-10-27 Dalhousie University Methods for tissue decellularization
WO2011132089A3 (en) * 2010-02-26 2012-03-01 Dalhousie University Methods for tissue decellularization
US9566369B2 (en) 2010-02-26 2017-02-14 Decell Technologies Inc. Methods for tissue decellularization
US10307510B2 (en) 2013-11-04 2019-06-04 Lifecell Corporation Methods of removing alpha-galactose

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CA2396698C (en) 2010-11-02
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US6866686B2 (en) 2005-03-15
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EP1591078A1 (en) 2005-11-02
NO20023154D0 (en) 2002-06-28
AU3307201A (en) 2001-08-07
WO2001054619A1 (en) 2001-08-02
JP2004500188A (en) 2004-01-08
US20050191281A1 (en) 2005-09-01
DK1591078T3 (en) 2009-11-16
CY1109458T1 (en) 2014-08-13
US20020128724A1 (en) 2002-09-12
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US20100285587A1 (en) 2010-11-11
US7763081B2 (en) 2010-07-27
NO327637B1 (en) 2009-09-07
EP1250109A1 (en) 2002-10-23
DE60139279D1 (en) 2009-08-27
ES2329480T3 (en) 2009-11-26
AU783780B2 (en) 2005-12-08
NO20023154L (en) 2002-06-28

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