CA2391685A1 - Medicinal implant and device and method for loading and delivering implants containing drugs and cells - Google Patents
Medicinal implant and device and method for loading and delivering implants containing drugs and cells Download PDFInfo
- Publication number
- CA2391685A1 CA2391685A1 CA002391685A CA2391685A CA2391685A1 CA 2391685 A1 CA2391685 A1 CA 2391685A1 CA 002391685 A CA002391685 A CA 002391685A CA 2391685 A CA2391685 A CA 2391685A CA 2391685 A1 CA2391685 A1 CA 2391685A1
- Authority
- CA
- Canada
- Prior art keywords
- lumen
- needle
- medicament
- implant
- plunger
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0069—Devices for implanting pellets, e.g. markers or solid medicaments
Abstract
A system for injecting controlled release medicinal implants has a syringe-like injector body with a lumen and plunger. A needle is attached to the injector body and receives therein an injectable implant with an internal hollow. The implant is retained in the needle by friction, which is overcome by the plunger upon dispensing. As the plunger moves from the retracted position to the deployed position, it forces a medicament previously loaded into the injector body into the implant hollow and then pushes the implant out of the needle into the creature into which the needle has been inserted. The implant may contain a filler to absorb flowable medicaments to aid in their retention within the implant. As in known implants, the medicament is released gradually depending upon the dissolution rate of the implant body which is formed from a biodegradable material. Because the medicament is loaded into the implant at the time of injection, issues concerning the reaction of the medicament with the implant material during preparation and storage are eliminated.
Claims (24)
1. A system for implanting medicinal implants into the body of a living creature, comprising:
an injector body with a first lumen therein;
a plunger slideable within said first lumen between a retracted position and a deployed position;
a needle having a second-lumen therein, said needle coupled to said injector body with said second lumen communicating with said first lumen;
an injectable implant having an internal hollow and positionable within at least one of said first lumen and said second lumen, said hollow communicating with said first lumen;
a medicament, storable at least partially within said first lumen when said plunger is in said retracted position, said internal hollow of said injectable implant receiving at least a portion of said medicament when said plunger is moved from said retracted position to said deployed position, said plunger pushing said injectable implant through said second lumen and out of said needle when said plunger assumes said deployed position.
an injector body with a first lumen therein;
a plunger slideable within said first lumen between a retracted position and a deployed position;
a needle having a second-lumen therein, said needle coupled to said injector body with said second lumen communicating with said first lumen;
an injectable implant having an internal hollow and positionable within at least one of said first lumen and said second lumen, said hollow communicating with said first lumen;
a medicament, storable at least partially within said first lumen when said plunger is in said retracted position, said internal hollow of said injectable implant receiving at least a portion of said medicament when said plunger is moved from said retracted position to said deployed position, said plunger pushing said injectable implant through said second lumen and out of said needle when said plunger assumes said deployed position.
2. The system of Claim 1, wherein said implant is biodegradable and provides a selected rate of release of said medicament into the body of the creature.
3. The system of Claim 2, wherein said injectable implant is formed from a material selected from the group consisting of biodegradable polymers, biopolymers, bioabsorbable starches and blends thereof.
4. The system of Claim 1, wherein the phase of said medicament is selected from the group consisting of solid, liquid, gel, suspensions and paste.
5. The system of Claim 4, wherein said medicament has an active agent component selected from the group consisting of antibiotics, antiviral agents, .
anticancer agents, anti-rejection agents, analgesics, anti-inflammatory agents, hormones, antigens, cyotkines, attachment factors, genes, peptides, proteins, nucleotides, carbohydrates, cells, cell fragments, growth factors, polysaccharides, glycoproteins and lipoproteins.
anticancer agents, anti-rejection agents, analgesics, anti-inflammatory agents, hormones, antigens, cyotkines, attachment factors, genes, peptides, proteins, nucleotides, carbohydrates, cells, cell fragments, growth factors, polysaccharides, glycoproteins and lipoproteins.
6. The system of Claim 1, wherein said injectable implant has an input opening to admit said medicament and a vent to discharge gas displaced by said medicament.
7. The system of Claim 6, wherein said injectable implant is substantially tubular in shape.
8. The system of Claim 6, wherein said injectable implant has cross-sectional dimensions approximating the cross-sectional dimensions of said first lumen.
9. The system of Claim 1, further including a fitter disposed within said internal hollow of said injectable implant, said medicament diffusable into said filler.
10. The system of Claim 9, wherein said filter is a biodegradable fiber.
11. The system of Claim 1, wherein said injectable implant has a friction fit relationship relative to at least one of said first lumen and said second lumen.
12. The system of Claim 1, further including a seal disposed in a distal end of said first lumen, said seal retaining said medicament within said first lumen when said plunger is in said retracted position.
13. The system of Claim 12, wherein said seal is a removable plug.
14. The system of Claim 12, wherein said seal is a rupturable membrane.
15. The system of Claim 1, wherein said needle is removably coupled to said injector body.
16. The system of Claim 15, wherein said injector body includes an elongated cylindrical barrel with a threaded nipple at a distal end thereof, said needle having a peripheral collar disposed proximate a first end thereof and further comprising a needle retention cap having a threaded bore terminating in a bridging cap member with a needle bore therein for accommodating said needle therethrough, said threaded bore being threadedly receivable on said threaded nipple, said bridging cap member abutting said peripheral collar for urging said needle toward said threaded nipple when said needle retention cap is threadedly received thereon.
17. The system of Claim 16, wherein said nipple has a needle aperture therethrough communicating with said first lumen, said needle aperture slideably receiving said first end of said needle, and further comprising a gasket slideable over said needle proximate said first end, said gasket being captured between said collar and said nipple when said needle retention cap is received on said nipple.
18. The system of Claim 15 wherein said needle is removably coupled to said injection body by a Leur-type connector.
19. A method for introducing a medicament into the body of a living creature, comprising the steps of:
(A) providing an injector having a first lumen therein, a plunger slideable within the first lumen between a retracted position and a deployed position and a needle with a second lumen disposed at one end of the injector for penetrating the body of the creature;
(B) providing an injectable implant with an internal hollow therein;
(C) charging the first lumen with a medicament;
(D) inserting the injectable implant into the second lumen;
(E) penetrating the body of the creature with the needle;
(F) moving the plunger from the retracted position to the deployed position, the plunger moving the medicament into the hollow of the injectable implant as it moves from the retracted position towards an intermediate position contacting the injectable implant and pushing the injectable implant out of the needle and into the body of the creature as the plunger moves to the deployed position.
(A) providing an injector having a first lumen therein, a plunger slideable within the first lumen between a retracted position and a deployed position and a needle with a second lumen disposed at one end of the injector for penetrating the body of the creature;
(B) providing an injectable implant with an internal hollow therein;
(C) charging the first lumen with a medicament;
(D) inserting the injectable implant into the second lumen;
(E) penetrating the body of the creature with the needle;
(F) moving the plunger from the retracted position to the deployed position, the plunger moving the medicament into the hollow of the injectable implant as it moves from the retracted position towards an intermediate position contacting the injectable implant and pushing the injectable implant out of the needle and into the body of the creature as the plunger moves to the deployed position.
20. The method of Claim 19, further comprising the step of assembling the needle to the injector just prior to moving the plunger in said step (F)
21. The method of Claim 20, further comprising the step of sterilizing the injector and the injectable implant separately from the medicament and prior to moving the medicament into the hollow of the injectable implant in said step (F).
22. The method of Claim 19, further comprising the step of sealing the medicament in the first lumen after charging he first lumen with medicament in said step (C) and overcoming the sealing of the medicament in the first lumen prior to said step of moving the medicament into the hollow of the injectable implant in said step (F).
23. The method of Claim 19, wherein the medicament has approximately the same volume as said hollow.
24. The method of Claim 19, wherein the medicament includes living cells and further comprising the step of waiting to move the plunger after the plunger has reached the intermediate position in order to allow the cells to interact with the injectable implant prior to penetrating the body with the needle and prior to injecting the injectable implant into the body of the creature.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/892,342 | 2001-06-27 | ||
| US09/892,342 US6648849B2 (en) | 2001-06-27 | 2001-06-27 | Medicinal implant and device and method for loading and delivering implants containing drugs and cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2391685A1 true CA2391685A1 (en) | 2002-12-27 |
| CA2391685C CA2391685C (en) | 2011-08-02 |
Family
ID=25399816
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2391685A Expired - Fee Related CA2391685C (en) | 2001-06-27 | 2002-06-26 | Medicinal implant and device and method for loading and delivering implants containing drugs and cells |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6648849B2 (en) |
| EP (1) | EP1281416B1 (en) |
| JP (1) | JP4236874B2 (en) |
| AT (1) | ATE318635T1 (en) |
| AU (1) | AU782591B2 (en) |
| CA (1) | CA2391685C (en) |
| DE (1) | DE60209446T2 (en) |
| ES (1) | ES2259066T3 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| RU2494766C2 (en) * | 2007-07-25 | 2013-10-10 | Инноваселл Биотехнологи Аг | Injection device for injection in biological tissue, medical device with such injection device, as well as method for injection using such injection device |
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-
2001
- 2001-06-27 US US09/892,342 patent/US6648849B2/en not_active Expired - Lifetime
-
2002
- 2002-06-25 AU AU48941/02A patent/AU782591B2/en not_active Ceased
- 2002-06-26 EP EP02254455A patent/EP1281416B1/en not_active Expired - Lifetime
- 2002-06-26 CA CA2391685A patent/CA2391685C/en not_active Expired - Fee Related
- 2002-06-26 AT AT02254455T patent/ATE318635T1/en not_active IP Right Cessation
- 2002-06-26 ES ES02254455T patent/ES2259066T3/en not_active Expired - Lifetime
- 2002-06-26 DE DE60209446T patent/DE60209446T2/en not_active Expired - Lifetime
- 2002-06-26 JP JP2002186711A patent/JP4236874B2/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2494766C2 (en) * | 2007-07-25 | 2013-10-10 | Инноваселл Биотехнологи Аг | Injection device for injection in biological tissue, medical device with such injection device, as well as method for injection using such injection device |
| US9333307B2 (en) | 2007-07-25 | 2016-05-10 | Innovacell Biotechnologie Ag | Injection device for injection into biological tissue and injection depot |
Also Published As
| Publication number | Publication date |
|---|---|
| DE60209446D1 (en) | 2006-04-27 |
| AU4894102A (en) | 2003-01-02 |
| ES2259066T3 (en) | 2006-09-16 |
| DE60209446T2 (en) | 2006-10-12 |
| ATE318635T1 (en) | 2006-03-15 |
| AU782591B2 (en) | 2005-08-11 |
| JP4236874B2 (en) | 2009-03-11 |
| JP2003111841A (en) | 2003-04-15 |
| EP1281416A2 (en) | 2003-02-05 |
| EP1281416B1 (en) | 2006-03-01 |
| CA2391685C (en) | 2011-08-02 |
| EP1281416A3 (en) | 2003-02-19 |
| US20030004491A1 (en) | 2003-01-02 |
| US6648849B2 (en) | 2003-11-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20150626 |