CA2381153A1 - System and method for delivering agents into targeted tissue of a living being - Google Patents

System and method for delivering agents into targeted tissue of a living being Download PDF

Info

Publication number
CA2381153A1
CA2381153A1 CA002381153A CA2381153A CA2381153A1 CA 2381153 A1 CA2381153 A1 CA 2381153A1 CA 002381153 A CA002381153 A CA 002381153A CA 2381153 A CA2381153 A CA 2381153A CA 2381153 A1 CA2381153 A1 CA 2381153A1
Authority
CA
Canada
Prior art keywords
tissue
tissues
channels
systems
living
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002381153A
Other languages
French (fr)
Other versions
CA2381153C (en
Inventor
John E. Nash
Douglas G. Evans
David M. Hoganson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM Biomedical Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2381153A1 publication Critical patent/CA2381153A1/en
Application granted granted Critical
Publication of CA2381153C publication Critical patent/CA2381153C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B17/3203—Fluid jet cutting instruments
    • A61B17/32037—Fluid jet cutting instruments for removing obstructions from inner organs or blood vessels, e.g. for atherectomy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B17/3205—Excision instruments
    • A61B17/3207—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions
    • A61B17/320758—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions with a rotating cutting instrument, e.g. motor driven
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/34—Trocars; Puncturing needles
    • A61B17/3478—Endoscopic needles, e.g. for infusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00238—Type of minimally invasive operation
    • A61B2017/00243—Type of minimally invasive operation cardiac
    • A61B2017/00247—Making holes in the wall of the heart, e.g. laser Myocardial revascularization
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00292—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery mounted on or guided by flexible, e.g. catheter-like, means
    • A61B2017/003—Steerable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22038—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with a guide wire
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00184—Moving parts
    • A61B2018/00202—Moving parts rotating
    • A61B2018/00208—Moving parts rotating actively driven, e.g. by a motor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00273—Anchoring means for temporary attachment of a device to tissue
    • A61B2018/00291—Anchoring means for temporary attachment of a device to tissue using suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00345—Vascular system
    • A61B2018/00351—Heart
    • A61B2018/00392—Transmyocardial revascularisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00773—Sensed parameters
    • A61B2018/00839—Bioelectrical parameters, e.g. ECG, EEG
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
    • A61B2018/1861—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves with an instrument inserted into a body lumen or cavity, e.g. a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B2018/2005—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser with beam delivery through an interstitially insertable device, e.g. needle

Abstract

The systems basically comprise a delivery system for accessing the targeted tissue within the living being and introduction of at least one agent at select locations into the myocardium and other select tissues. The delivery systems are arranged to access the tissues of the heart. One or more of the systems can be utilized during transluminal, transthoracic and direct surgical access procedures. Where appropriate, for example in the case of intraventricular access, portions of the system are steerable to properly orient the device. The instruments may pierce the heart tissue and create channels extending from the endocardium, the epicardium, or the cardiac vessels. When tissue penetration is utilized, the device may include a feature to control the depth of penetration. To minimize bleeding through the channels the device can dilate small initial punctures that later contract down after device removal.
When the formation of channels is required, this can be achieved, by way of example, with a rotary-tipped device, pressurized fluid jet devices, vibratory instruments and piercing needle-like tip devices. The system may utilize some form of mechanical action or application of energy (e.g. electrical, sonic, thermal, optical, pressurized fluid, radio frequency (RF), nuclear) in the process. The mechanical action or energy application may affect the surrounding tissues at a distance from the device. The agent delivered to the tissue may include one or more of pharmaceuticals, biologically active agents, radiopaque materials, etc.
CA002381153A 1999-08-05 2000-07-28 System and method for delivering agents into targeted tissue of a living being Expired - Lifetime CA2381153C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/368,410 US6709427B1 (en) 1999-08-05 1999-08-05 Systems and methods for delivering agents into targeted tissue of a living being
US09/368,410 1999-08-05
PCT/US2000/020525 WO2001010313A1 (en) 1999-08-05 2000-07-28 System and method for delivering agents into targeted tissue of a living being

Publications (2)

Publication Number Publication Date
CA2381153A1 true CA2381153A1 (en) 2001-02-15
CA2381153C CA2381153C (en) 2007-11-27

Family

ID=23451089

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002381153A Expired - Lifetime CA2381153C (en) 1999-08-05 2000-07-28 System and method for delivering agents into targeted tissue of a living being

Country Status (7)

Country Link
US (5) US6709427B1 (en)
EP (1) EP1206219B1 (en)
JP (1) JP3712668B2 (en)
AU (1) AU6611200A (en)
CA (1) CA2381153C (en)
DE (1) DE60041196D1 (en)
WO (1) WO2001010313A1 (en)

Families Citing this family (175)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0758385A (en) * 1993-08-13 1995-03-03 Ishikawajima Harima Heavy Ind Co Ltd Supersonic gas laser generator
AU716005B2 (en) 1995-06-07 2000-02-17 Cook Medical Technologies Llc Implantable medical device
US6569147B1 (en) 1996-07-26 2003-05-27 Kensey Nash Corporation Systems and methods of use for delivering beneficial agents for revascularizing stenotic bypass grafts and other occluded blood vessels and for other purposes
US5779721A (en) 1996-07-26 1998-07-14 Kensey Nash Corporation System and method of use for revascularizing stenotic bypass grafts and other blood vessels
US6905505B2 (en) 1996-07-26 2005-06-14 Kensey Nash Corporation System and method of use for agent delivery and revascularizing of grafts and vessels
US6080170A (en) 1996-07-26 2000-06-27 Kensey Nash Corporation System and method of use for revascularizing stenotic bypass grafts and other occluded blood vessels
US6511477B2 (en) * 1997-03-13 2003-01-28 Biocardia, Inc. Method of drug delivery to interstitial regions of the myocardium
EP1112043B1 (en) * 1998-09-10 2006-04-05 Percardia, Inc. Tmr shunt
US6254564B1 (en) 1998-09-10 2001-07-03 Percardia, Inc. Left ventricular conduit with blood vessel graft
US6638237B1 (en) * 1999-08-04 2003-10-28 Percardia, Inc. Left ventricular conduits and methods for delivery
US6709427B1 (en) * 1999-08-05 2004-03-23 Kensey Nash Corporation Systems and methods for delivering agents into targeted tissue of a living being
US6811551B2 (en) * 1999-12-14 2004-11-02 Radiant Medical, Inc. Method for reducing myocardial infarct by application of intravascular hypothermia
US8474460B2 (en) 2000-03-04 2013-07-02 Pulmonx Corporation Implanted bronchial isolation devices and methods
EP1311195A4 (en) * 2000-08-24 2005-08-31 Timi 3 Systems Inc Systems and methods for applying ultrasonic energy to the thoracic cavity and other targeted body regions
AU2001286940A1 (en) * 2000-09-22 2002-04-02 Kensey Nash Corporation Drug delivering prostheses and methods of use
AU2001290820A1 (en) * 2000-09-22 2002-04-02 Kensey Nash Corporation Systems and methods for delivering beneficial agents into targeted tissue of a living being
US7357794B2 (en) 2002-01-17 2008-04-15 Medtronic Vascular, Inc. Devices, systems and methods for acute or chronic delivery of substances or apparatus to extravascular treatment sites
US6976990B2 (en) * 2001-01-25 2005-12-20 Percardia, Inc. Intravascular ventriculocoronary bypass via a septal passageway
US20070038244A1 (en) * 2001-06-08 2007-02-15 Morris Edward J Method and apparatus for sealing access
US7993365B2 (en) * 2001-06-08 2011-08-09 Morris Innovative, Inc. Method and apparatus for sealing access
US20060004408A1 (en) * 2001-06-08 2006-01-05 Morris Edward J Method and apparatus for sealing access
US20030036698A1 (en) * 2001-08-16 2003-02-20 Robert Kohler Interventional diagnostic catheter and a method for using a catheter to access artificial cardiac shunts
US20030050648A1 (en) 2001-09-11 2003-03-13 Spiration, Inc. Removable lung reduction devices, systems, and methods
WO2003030975A2 (en) * 2001-10-11 2003-04-17 Emphasys Medical, Inc. Bronchial flow control devices and methods of use
US6592594B2 (en) 2001-10-25 2003-07-15 Spiration, Inc. Bronchial obstruction device deployment system and method
US20040054286A1 (en) * 2001-11-05 2004-03-18 Audain Vaughn A Ultrasonic transducing probe with liquid flow-through capability and related automated workstation and methods of using same
WO2003053491A2 (en) * 2001-11-09 2003-07-03 Cardio-Optics, Inc. Coronary sinus access catheter with forward-imaging
US6949118B2 (en) * 2002-01-16 2005-09-27 Percardia, Inc. Encased implant and methods
US7008397B2 (en) * 2002-02-13 2006-03-07 Percardia, Inc. Cardiac implant and methods
US7169127B2 (en) * 2002-02-21 2007-01-30 Boston Scientific Scimed, Inc. Pressure apron direct injection catheter
US20030163111A1 (en) * 2002-02-26 2003-08-28 Daellenbach Keith K. End effector for needle-free injection system
US20030216769A1 (en) 2002-05-17 2003-11-20 Dillard David H. Removable anchored lung volume reduction devices and methods
US20030181922A1 (en) 2002-03-20 2003-09-25 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US7108685B2 (en) 2002-04-15 2006-09-19 Boston Scientific Scimed, Inc. Patch stabilization of rods for treatment of cardiac muscle
US20030220661A1 (en) * 2002-05-21 2003-11-27 Heartstent Corporation Transmyocardial implant delivery system
US20060100514A1 (en) * 2002-07-08 2006-05-11 Prorhythm, Inc. Cardiac ablation using microbubbles
AU2003256798A1 (en) 2002-07-26 2004-02-16 Emphasys Medical, Inc. Bronchial flow control devices with membrane seal
US7008411B1 (en) * 2002-09-30 2006-03-07 Advanced Cardiovascular Systems, Inc. Method and apparatus for treating vulnerable plaque
US20060265043A1 (en) * 2002-09-30 2006-11-23 Evgenia Mandrusov Method and apparatus for treating vulnerable plaque
US7326238B1 (en) 2002-09-30 2008-02-05 Abbott Cardiovascular Systems Inc. Method and apparatus for treating vulnerable plaque
US7103418B2 (en) 2002-10-02 2006-09-05 Medtronic, Inc. Active fluid delivery catheter
FR2846520B1 (en) * 2002-11-06 2006-09-29 Roquette Freres USE OF MALTODEXTRINS BRANCHED AS BLEACHES OF GRANULATION
US7317950B2 (en) * 2002-11-16 2008-01-08 The Regents Of The University Of California Cardiac stimulation system with delivery of conductive agent
US20050015048A1 (en) 2003-03-12 2005-01-20 Chiu Jessica G. Infusion treatment agents, catheters, filter devices, and occlusion devices, and use thereof
US7250041B2 (en) 2003-03-12 2007-07-31 Abbott Cardiovascular Systems Inc. Retrograde pressure regulated infusion
US20040265351A1 (en) * 2003-04-10 2004-12-30 Miller Richard L. Methods and compositions for enhancing immune response
US8383158B2 (en) * 2003-04-15 2013-02-26 Abbott Cardiovascular Systems Inc. Methods and compositions to treat myocardial conditions
US7533671B2 (en) 2003-08-08 2009-05-19 Spiration, Inc. Bronchoscopic repair of air leaks in a lung
US20050059931A1 (en) * 2003-09-16 2005-03-17 Venomatrix Methods and apparatus for localized and semi-localized drug delivery
US20050059930A1 (en) * 2003-09-16 2005-03-17 Michi Garrison Method and apparatus for localized drug delivery
US20050175709A1 (en) * 2003-12-11 2005-08-11 Baty Ace M.Iii Therapeutic microparticles
US7632262B2 (en) * 2004-07-19 2009-12-15 Nexeon Medical Systems, Inc. Systems and methods for atraumatic implantation of bio-active agents
WO2006015353A2 (en) * 2004-07-30 2006-02-09 Washington University In St. Louis Surgical cooling system and method
US8750983B2 (en) 2004-09-20 2014-06-10 P Tech, Llc Therapeutic system
US20060074344A1 (en) * 2004-09-29 2006-04-06 Hibner John A Fluid control for biopsy device
US7276032B2 (en) * 2004-09-29 2007-10-02 Ethicon Endo-Surgery, Inc. Biopsy apparatus and method
US7819856B2 (en) * 2004-10-05 2010-10-26 Nexeon Medical Systems, Inc. Methods and apparatus for treating infarcted regions of tissue following acute myocardial infarction
US20060079841A1 (en) * 2004-10-07 2006-04-13 University Technologies International Inc. Rapid insufflation drug compartment
US8663225B2 (en) * 2004-11-12 2014-03-04 Medtronic, Inc. Hydrogel bone void filler
US7771472B2 (en) 2004-11-19 2010-08-10 Pulmonx Corporation Bronchial flow control devices and methods of use
US8262605B2 (en) 2004-12-09 2012-09-11 Ams Research Corporation Needleless delivery systems
JP4804906B2 (en) * 2004-12-15 2011-11-02 ドルニエル メドテック システムズ ゲーエムベーハー Shock wave improved methods of cell therapy and tissue regeneration in patients with cardiovascular and neurological diseases
US20060142773A1 (en) * 2004-12-29 2006-06-29 Depuy Mitek, Inc. Abrasive cutting system and method
DE102005003632A1 (en) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Catheter for the transvascular implantation of heart valve prostheses
US7226440B2 (en) * 2005-01-31 2007-06-05 G & L Consulting, Llc Method and device for accessing a pericardial space
US8876791B2 (en) 2005-02-25 2014-11-04 Pulmonx Corporation Collateral pathway treatment using agent entrained by aspiration flow current
US20070100199A1 (en) * 2005-11-03 2007-05-03 Lilip Lau Apparatus and method of delivering biomaterial to the heart
US20070141106A1 (en) * 2005-10-19 2007-06-21 Bonutti Peter M Drug eluting implant
US20070148227A1 (en) * 2005-12-27 2007-06-28 Hemant Joshi Physically/molecularly distributed and/or chemically bound medicaments in capsule shells
US20090312696A1 (en) * 2005-12-28 2009-12-17 Copa Vincent G Devices, Systems, and Related Methods for Delivery of Fluid to Tissue
US20080033296A1 (en) * 2006-02-17 2008-02-07 Florida Gulf Coast University Methods for delivering materials into biological systems using sonic energy
US7691151B2 (en) 2006-03-31 2010-04-06 Spiration, Inc. Articulable Anchor
US8206370B2 (en) * 2006-04-21 2012-06-26 Abbott Laboratories Dual lumen guidewire support catheter
US8246574B2 (en) * 2006-04-21 2012-08-21 Abbott Laboratories Support catheter
US7927305B2 (en) * 2006-04-21 2011-04-19 Abbott Laboratories Systems, methods, and devices for injecting media contrast
US20070250149A1 (en) * 2006-04-21 2007-10-25 Abbott Laboratories Stiffening Support Catheters and Methods for Using the Same
US7993303B2 (en) * 2006-04-21 2011-08-09 Abbott Laboratories Stiffening support catheter and methods for using the same
US8388573B1 (en) 2006-06-28 2013-03-05 Abbott Cardiovascular Systems Inc. Local delivery with a balloon covered by a cage
US10369343B2 (en) * 2006-06-30 2019-08-06 Biocompatibles Uk Limited Apparatus and method to convey a fluid
US7846361B2 (en) 2006-07-20 2010-12-07 Orbusneich Medical, Inc. Bioabsorbable polymeric composition for a medical device
US20080097297A1 (en) * 2006-08-31 2008-04-24 Kelley Gregory S Medical device for local site-specific drug delivery
AU2007292923B2 (en) * 2006-09-08 2013-10-03 Cardiopolymers, Inc. Intramyocardial patterning for global cardiac resizing and reshaping
PL2061385T3 (en) 2006-09-13 2015-06-30 Vascular Insights Llc Vascular treatment device
US7942845B2 (en) * 2006-09-19 2011-05-17 Bioject, Inc. Needle-free injector and process for providing serial injections
US7959942B2 (en) 2006-10-20 2011-06-14 Orbusneich Medical, Inc. Bioabsorbable medical device with coating
EP2073754A4 (en) 2006-10-20 2012-09-26 Orbusneich Medical Inc Bioabsorbable polymeric composition and medical device background
US7862576B2 (en) * 2006-11-06 2011-01-04 The Regents Of The University Of Michigan Angioplasty balloon with therapeutic/aspiration channel
US9005672B2 (en) 2006-11-17 2015-04-14 Abbott Cardiovascular Systems Inc. Methods of modifying myocardial infarction expansion
US20080119823A1 (en) 2006-11-21 2008-05-22 Crank Justin M Injection Tube for Jet Injection Device
EP2810613B1 (en) * 2007-01-02 2019-03-20 AquaBeam LLC Minimally invasive devices for the treatment of prostate diseases
US9232959B2 (en) 2007-01-02 2016-01-12 Aquabeam, Llc Multi fluid tissue resection methods and devices
US9375164B2 (en) 2007-03-08 2016-06-28 Sync-Rx, Ltd. Co-use of endoluminal data and extraluminal imaging
US11197651B2 (en) 2007-03-08 2021-12-14 Sync-Rx, Ltd. Identification and presentation of device-to-vessel relative motion
US9305334B2 (en) 2007-03-08 2016-04-05 Sync-Rx, Ltd. Luminal background cleaning
US9629571B2 (en) 2007-03-08 2017-04-25 Sync-Rx, Ltd. Co-use of endoluminal data and extraluminal imaging
US9968256B2 (en) 2007-03-08 2018-05-15 Sync-Rx Ltd. Automatic identification of a tool
US8781193B2 (en) 2007-03-08 2014-07-15 Sync-Rx, Ltd. Automatic quantitative vessel analysis
US10716528B2 (en) 2007-03-08 2020-07-21 Sync-Rx, Ltd. Automatic display of previously-acquired endoluminal images
US11064964B2 (en) 2007-03-08 2021-07-20 Sync-Rx, Ltd Determining a characteristic of a lumen by measuring velocity of a contrast agent
EP2129284A4 (en) * 2007-03-08 2012-11-28 Sync Rx Ltd Imaging and tools for use with moving organs
CA2682160C (en) 2007-04-11 2017-04-04 Henry Ford Health System Cardiac repair, resizing and reshaping using the venous system of the heart
US7896915B2 (en) 2007-04-13 2011-03-01 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
US20090024106A1 (en) * 2007-07-17 2009-01-22 Morris Edward J Method and apparatus for maintaining access
US8100855B2 (en) 2007-09-17 2012-01-24 Abbott Cardiovascular Systems, Inc. Methods and devices for eluting agents to a vessel
JP5570993B2 (en) 2007-10-12 2014-08-13 スピレーション インコーポレイテッド Valve loader methods, systems, and apparatus
US20090137949A1 (en) * 2007-11-26 2009-05-28 Bioject Inc. Needle-free injection device with nozzle auto-disable
US8617099B2 (en) * 2007-11-26 2013-12-31 Bioject Inc. Injection device plunger auto-disable
ES2903231T3 (en) 2008-02-26 2022-03-31 Jenavalve Tech Inc Stent for positioning and anchoring a valve prosthesis at an implantation site in a patient's heart
US9044318B2 (en) 2008-02-26 2015-06-02 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis
WO2009111736A1 (en) 2008-03-06 2009-09-11 Aquabeam Llc Tissue ablation and cautery with optical energy carried in fluid stream
US8801665B2 (en) 2008-04-10 2014-08-12 Henry Ford Health System Apparatus and method for controlled depth of injection into myocardial tissue
US8403913B2 (en) 2008-06-16 2013-03-26 John Richard Dein Variable diameter surgical drains and sheaths
US8118832B1 (en) 2008-06-16 2012-02-21 Morris Innovative, Inc. Method and apparatus for sealing access
ES2450391T3 (en) 2008-06-19 2014-03-24 Sync-Rx, Ltd. Progressive progress of a medical instrument
US8642063B2 (en) 2008-08-22 2014-02-04 Cook Medical Technologies Llc Implantable medical device coatings with biodegradable elastomer and releasable taxane agent
US8551074B2 (en) * 2008-09-08 2013-10-08 Bayer Pharma AG Connector system having a compressible sealing element and a flared fluid path element
US11064903B2 (en) 2008-11-18 2021-07-20 Sync-Rx, Ltd Apparatus and methods for mapping a sequence of images to a roadmap image
US9974509B2 (en) 2008-11-18 2018-05-22 Sync-Rx Ltd. Image super enhancement
US10362962B2 (en) 2008-11-18 2019-07-30 Synx-Rx, Ltd. Accounting for skipped imaging locations during movement of an endoluminal imaging probe
US9101286B2 (en) 2008-11-18 2015-08-11 Sync-Rx, Ltd. Apparatus and methods for determining a dimension of a portion of a stack of endoluminal data points
US9095313B2 (en) 2008-11-18 2015-08-04 Sync-Rx, Ltd. Accounting for non-uniform longitudinal motion during movement of an endoluminal imaging probe
US8855744B2 (en) 2008-11-18 2014-10-07 Sync-Rx, Ltd. Displaying a device within an endoluminal image stack
US9144394B2 (en) 2008-11-18 2015-09-29 Sync-Rx, Ltd. Apparatus and methods for determining a plurality of local calibration factors for an image
WO2010064222A2 (en) 2008-12-01 2010-06-10 University College Cork, National University Of Ireland, Cork Igf1 for myocardial repair
US20110046600A1 (en) * 2008-12-05 2011-02-24 Crank Justin M Devices, systems, and related methods for delivery of fluid to tissue
WO2010065133A2 (en) * 2008-12-05 2010-06-10 Ams Research Corporation Devices, systems, and related methods for delivery of fluid to tissue
EP2384209A2 (en) 2008-12-16 2011-11-09 AMS Research Corporation Needleless injection device components, systems, and methods
WO2010093834A2 (en) * 2009-02-12 2010-08-19 Incube Labs, Llc Skin penetrating device and method for subcutaneous solid drug delivery
US20100261662A1 (en) * 2009-04-09 2010-10-14 Endologix, Inc. Utilization of mural thrombus for local drug delivery into vascular tissue
US20100292582A1 (en) * 2009-05-13 2010-11-18 Dasilva Luiz B Tissue probe with speed control
AU2010276366B2 (en) 2009-07-20 2015-01-29 Ams Research Corporation Devices, systems, and methods for delivering fluid to tissue
CA2757660A1 (en) * 2009-07-20 2011-01-27 Ams Research Corporation Tissue tensioner assembly
US20110028848A1 (en) * 2009-07-31 2011-02-03 Cem Shaquer Methods and Apparatus for Detecting and Mapping Tissue Interfaces
JP5696949B2 (en) * 2009-10-26 2015-04-08 バイオレイズ，インク． High power radiation source including active medium housing
WO2011068540A1 (en) 2009-12-03 2011-06-09 Therix Medical Development, Ltd. Central venous access system
JP2013526388A (en) 2010-05-25 2013-06-24 イエナバルブ テクノロジー インク Artificial heart valve, and transcatheter delivery prosthesis comprising an artificial heart valve and a stent
CN103025378B (en) 2010-07-13 2015-10-07 蓝带技术公司 With the method and apparatus of Rhizoma Atractylodis Macrocephalae cardiac tissue injection
US9943668B2 (en) 2010-07-16 2018-04-17 Sub3 Vascular, Llc Guidewire and catheter system and method for treating a blood clot
US9585667B2 (en) 2010-11-15 2017-03-07 Vascular Insights Llc Sclerotherapy catheter with lumen having wire rotated by motor and simultaneous withdrawal from vein
US8979797B2 (en) 2010-12-16 2015-03-17 Ams Research Corporation High pressure delivery system and method for treating pelvic disorder using large molecule therapeutics
US8998985B2 (en) * 2011-07-25 2015-04-07 Rainbow Medical Ltd. Sinus stent
WO2013044267A1 (en) 2011-09-23 2013-03-28 Pulmonx, Inc. Implant loading device and system
JP6203744B2 (en) 2011-12-08 2017-09-27 ユニヴァーシティ・オブ・ワシントン・スルー・イッツ・センター・フォー・コマーシャリゼーション Ultrasonic stylet
JP2015503954A (en) 2011-12-15 2015-02-05 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォードジュニア ユニバーシティＴｈｅ Ｂｏａｒｄ ｏｆ Ｔｒｕｓｔｅｅｓ ｏｆ ｔｈｅ Ｌｅｌａｎｄ Ｓｔａｎｆｏｒｄ Ｊｕｎｉｏｒ Ｕｎｉｖｅｒｓｉｔｙ Apparatus and method for treating pulmonary hypertension
US10092726B2 (en) 2012-02-09 2018-10-09 Bluegrass Vascular Technologies, Inc. Occlusion access system
EP3351196A1 (en) 2012-02-29 2018-07-25 Procept Biorobotics Corporation Automated image-guided tissue resection and treatment
JP6134789B2 (en) 2012-06-26 2017-05-24 シンク−アールエックス，リミティド Image processing related to flow in luminal organs
CN102908191A (en) 2012-11-13 2013-02-06 陈绍良 Multipolar synchronous pulmonary artery radiofrequency ablation catheter
US9827036B2 (en) 2012-11-13 2017-11-28 Pulnovo Medical (Wuxi) Co., Ltd. Multi-pole synchronous pulmonary artery radiofrequency ablation catheter
US11241267B2 (en) 2012-11-13 2022-02-08 Pulnovo Medical (Wuxi) Co., Ltd Multi-pole synchronous pulmonary artery radiofrequency ablation catheter
AU2013363571A1 (en) * 2012-12-17 2015-07-16 Cormatrix Cardiovascular, Inc. Intra-myocardial agent delivery device, system and method
US10076384B2 (en) 2013-03-08 2018-09-18 Symple Surgical, Inc. Balloon catheter apparatus with microwave emitter
JP6132660B2 (en) * 2013-05-27 2017-05-24 オリンパス株式会社 Body cavity expanding device and peristaltic pump control method
US10413359B2 (en) * 2013-07-18 2019-09-17 International Business Machines Corporation Laser-assisted transdermal delivery of nanoparticulates and hydrogels
JP6563394B2 (en) 2013-08-30 2019-08-21 イェーナヴァルヴ テクノロジー インコーポレイテッド Radially foldable frame for an artificial valve and method for manufacturing the frame
US20150173830A1 (en) * 2013-12-23 2015-06-25 Eric Johnson Treatment structure and methods of use
US9986949B2 (en) * 2014-03-05 2018-06-05 Biosense Webster (Israel) Ltd. Multi-arm catheter with signal transmission over braid wires
US9636210B2 (en) * 2014-05-19 2017-05-02 Mentor Worldwide Llc Injection zone markers for biomedical implants
US10279081B2 (en) * 2014-10-24 2019-05-07 Allosource Composite grafts, systems, and methods
EP3498319A1 (en) * 2015-01-16 2019-06-19 Becton Dickinson France Drug storage and dispensing system for pre-filled containers
US10709555B2 (en) 2015-05-01 2020-07-14 Jenavalve Technology, Inc. Device and method with reduced pacemaker rate in heart valve replacement
US10856892B2 (en) 2016-02-29 2020-12-08 Bluegrass Vascular Technologies, Inc. Catheter systems, kits, and methods for gaining access to a vessel
EP3454795B1 (en) 2016-05-13 2023-01-11 JenaValve Technology, Inc. Heart valve prosthesis delivery system for delivery of heart valve prosthesis with introducer sheath and loading system
WO2018129369A1 (en) * 2017-01-05 2018-07-12 Contraline, Inc. Methods for implanting and reversing stimuli-responsive implants
JP7094965B2 (en) 2017-01-27 2022-07-04 イエナバルブ テクノロジー インク Heart valve imitation
CN110573098B (en) 2017-05-03 2022-08-23 美敦力瓦斯科尔勒公司 Tissue removal catheter
US11690645B2 (en) 2017-05-03 2023-07-04 Medtronic Vascular, Inc. Tissue-removing catheter
US11179216B2 (en) * 2018-02-15 2021-11-23 Ethicon, Inc. System(s), method(s) and device(s) for the prevention of esophageal fistula during catheter ablation
US11357534B2 (en) 2018-11-16 2022-06-14 Medtronic Vascular, Inc. Catheter
US11819236B2 (en) 2019-05-17 2023-11-21 Medtronic Vascular, Inc. Tissue-removing catheter
US11696793B2 (en) 2021-03-19 2023-07-11 Crossfire Medical Inc Vascular ablation
EP4108197A1 (en) 2021-06-24 2022-12-28 Gradient Denervation Technologies Systems for treating tissue
GB202119002D0 (en) * 2021-12-24 2022-02-09 Creo Medical Ltd Fluid delivery apparatus for a surgical instrument
WO2023154803A1 (en) * 2022-02-10 2023-08-17 Avana Health, Inc. Device for treating uterine bleeding and method of use
US11911581B1 (en) 2022-11-04 2024-02-27 Controlled Delivery Systems, Inc. Catheters and related methods for the aspiration controlled delivery of closure agents

Family Cites Families (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1902418A (en) 1931-11-02 1933-03-21 Jensen Salsbery Lab Inc Surgical instrument
US2398544A (en) 1945-01-06 1946-04-16 Marshall L Lockhart Hypodermic injector
US2800903A (en) 1947-07-30 1957-07-30 Becton Dickinson Co Injection apparatus
US2737946A (en) 1949-09-01 1956-03-13 Jr George N Hein Hypodermic injection apparatus
US2727946A (en) * 1952-12-11 1955-12-20 Rca Corp Pulse multiplex transmitter system
US2762370A (en) 1954-09-07 1956-09-11 Scherer Corp R P Hypodermic injector
US3887699A (en) 1969-03-24 1975-06-03 Seymour Yolles Biodegradable polymeric article for dispensing drugs
US3815594A (en) 1972-08-10 1974-06-11 N Doherty Needleless inoculator
US3931667A (en) * 1974-05-08 1976-01-13 Dennison Manufacturing Company Interlocking attachment device
US3930505A (en) 1974-06-24 1976-01-06 Hydro Pulse Corporation Surgical apparatus for removal of tissue
US4165739A (en) 1976-09-02 1979-08-28 Doherty Norman R Inoculator
US4900303A (en) 1978-03-10 1990-02-13 Lemelson Jerome H Dispensing catheter and method
US4315742A (en) 1979-11-05 1982-02-16 Syntex (U.S.A.) Inc. Vibratory device having tool assembly with fluid transport means
US4406656A (en) 1981-06-01 1983-09-27 Brack Gillium Hattler Venous catheter having collapsible multi-lumens
US4637905A (en) 1982-03-04 1987-01-20 Batelle Development Corporation Process of preparing microcapsules of lactides or lactide copolymers with glycolides and/or ε-caprolactones
US4454875A (en) * 1982-04-15 1984-06-19 Techmedica, Inc. Osteal medical staple
JPS60100516A (en) 1983-11-04 1985-06-04 Takeda Chem Ind Ltd Preparation of sustained release microcapsule
US4589412A (en) 1984-01-03 1986-05-20 Intravascular Surgical Instruments, Inc. Method and apparatus for surgically removing remote deposits
US4631052A (en) 1984-01-03 1986-12-23 Intravascular Surgical Instruments, Inc. Method and apparatus for surgically removing remote deposits
DE8426270U1 (en) 1984-09-06 1985-02-14 Veltrup, Elmar Michael, Dipl.-Ing., 4150 Krefeld DEVICE FOR REMOVING SOLID BODIES OR DEPOSITS FROM BODY VESSELS
US4790813A (en) 1984-12-17 1988-12-13 Intravascular Surgical Instruments, Inc. Method and apparatus for surgically removing remote deposits
US4747406A (en) 1985-02-13 1988-05-31 Intravascular Surgical Instruments, Inc. Shaft driven, flexible intravascular recanalization catheter
US4686982A (en) 1985-06-19 1987-08-18 John Nash Spiral wire bearing for rotating wire drive catheter
US4658817A (en) 1985-04-01 1987-04-21 Children's Hospital Medical Center Method and apparatus for transmyocardial revascularization using a laser
US4700705A (en) 1985-08-12 1987-10-20 Intravascular Surgical Instruments, Inc. Catheter based surgical methods and apparatus therefor
US4679558A (en) 1985-08-12 1987-07-14 Intravascular Surgical Instruments, Inc. Catheter based surgical methods and apparatus therefor
US4664112A (en) 1985-08-12 1987-05-12 Intravascular Surgical Instruments, Inc. Catheter based surgical methods and apparatus therefor
US4839215A (en) 1986-06-09 1989-06-13 Ceramed Corporation Biocompatible particles and cloth-like article made therefrom
US4747821A (en) 1986-10-22 1988-05-31 Intravascular Surgical Instruments, Inc. Catheter with high speed moving working head
US4749376A (en) 1986-10-24 1988-06-07 Intravascular Surgical Instruments, Inc. Reciprocating working head catheter
US5718921A (en) 1987-03-13 1998-02-17 Massachusetts Institute Of Technology Microspheres comprising polymer and drug dispersed there within
US5912017A (en) 1987-05-01 1999-06-15 Massachusetts Institute Of Technology Multiwall polymeric microspheres
US4795438A (en) 1987-05-13 1989-01-03 Intravascular Surgical Instruments, Inc. Method and apparatus for forming a restriction in a vessel, duct or lumen
IT212331Z2 (en) 1987-11-27 1989-07-04 Lorenzo Molinari EQUIPMENT FOR ADJUSTABLE REMOVAL OF SURFACE PORTIONS OF HUMAN FABRIC
US4950238A (en) * 1988-07-07 1990-08-21 Clarence E. Sikes Hydro-rotary vascular catheter
US5021044A (en) 1989-01-30 1991-06-04 Advanced Cardiovascular Systems, Inc. Catheter for even distribution of therapeutic fluids
US5087244A (en) 1989-01-31 1992-02-11 C. R. Bard, Inc. Catheter and method for locally applying medication to the wall of a blood vessel or other body lumen
US4994033A (en) 1989-05-25 1991-02-19 Schneider (Usa) Inc. Intravascular drug delivery dilatation catheter
HU212760B (en) 1989-06-20 1997-02-28 Denes Method and device for the apportion of chemical materials into the vein wall
US5042984A (en) 1989-08-17 1991-08-27 Kensey Nash Corporation Catheter with working head having selectable impacting surfaces and method of using the same
JP2571874B2 (en) 1989-11-06 1997-01-16 アルカーメス コントロールド セラピューティクス，インコーポレイテッド Protein microsphere composition
US5135484A (en) * 1990-05-09 1992-08-04 Pioneering Technologies, Inc. Method of removing plaque from vessels
US5199951A (en) 1990-05-17 1993-04-06 Wayne State University Method of drug application in a transporting medium to an arterial wall injured during angioplasty
US5498238A (en) 1990-06-15 1996-03-12 Cortrak Medical, Inc. Simultaneous angioplasty and phoretic drug delivery
US5527292A (en) 1990-10-29 1996-06-18 Scimed Life Systems, Inc. Intravascular device for coronary heart treatment
US5885272A (en) * 1990-10-30 1999-03-23 Aita; Michael System and method for percutaneous myocardial revascularization
US5496267A (en) 1990-11-08 1996-03-05 Possis Medical, Inc. Asymmetric water jet atherectomy
US5170805A (en) * 1990-12-11 1992-12-15 Kensey Nash Corporation Method of destroying tissue such as a gall bladder utilizing a sclerosing agent alone or with a symphysis agent
US5893840A (en) 1991-01-04 1999-04-13 Medtronic, Inc. Releasable microcapsules on balloon catheters
NZ272209A (en) 1991-05-01 2001-02-23 Univ Columbia Myocardial revascularisation of the heart by a laser
GB9112267D0 (en) 1991-06-07 1991-07-24 Biocompatibles Ltd Polymeric coating
US5273526A (en) * 1991-06-21 1993-12-28 Lake Region Manufacturing Company, Inc. Vascular occulusion removal devices and method
US5288502A (en) 1991-10-16 1994-02-22 The University Of Texas System Preparation and uses of multi-phase microspheres
US5244460A (en) 1991-11-27 1993-09-14 The United States Of America As Represented By The Department Of Health And Human Services Method to foster myocardial blood vessel growth and improve blood flow to the heart
US5697882A (en) 1992-01-07 1997-12-16 Arthrocare Corporation System and method for electrosurgical cutting and ablation
DE4201992A1 (en) * 1992-01-25 1993-07-29 Hp Medica Gmbh Fuer Medizintec HIGH PRESSURE LIQUID DISPENSOR FOR DISPENSING STERILE LIQUID
US5569189A (en) 1992-09-28 1996-10-29 Equidyne Systems, Inc. hypodermic jet injector
US5279565A (en) 1993-02-03 1994-01-18 Localmed, Inc. Intravascular treatment apparatus and method
JPH08507715A (en) 1993-03-18 1996-08-20 シーダーズ サイナイ メディカル センター Drug-inducing and releasable polymeric coatings for bioartificial components
US5415637A (en) 1993-04-14 1995-05-16 Advanced Cardiovascular Systems, Inc. Temporary stenting catheter with drug delivery capabilities
US5358473A (en) * 1993-04-30 1994-10-25 Mitchell Paul G Apparatus and method for the removal of adherent viscoelastic material
US5456667A (en) 1993-05-20 1995-10-10 Advanced Cardiovascular Systems, Inc. Temporary stenting catheter with one-piece expandable segment
US5417703A (en) * 1993-07-13 1995-05-23 Scimed Life Systems, Inc. Thrombectomy devices and methods of using same
CA2127637C (en) * 1993-07-26 2006-01-03 Scott Bair Fluid jet surgical cutting tool
AU672305B2 (en) * 1993-09-02 1996-09-26 Barber Brake Beam Llc Anti-rotation member for railcar brake beam
US5415636A (en) * 1994-04-13 1995-05-16 Schneider (Usa) Inc Dilation-drug delivery catheter
US5836905A (en) * 1994-06-20 1998-11-17 Lemelson; Jerome H. Apparatus and methods for gene therapy
NL9401107A (en) 1994-07-01 1996-02-01 Cordis Europ Controlled bendable catheter.
US6152141A (en) * 1994-07-28 2000-11-28 Heartport, Inc. Method for delivery of therapeutic agents to the heart
US5820873A (en) 1994-09-30 1998-10-13 The University Of British Columbia Polyethylene glycol modified ceramide lipids and liposome uses thereof
ES2155534T3 (en) 1994-10-12 2001-05-16 Focal Inc ADMINISTRATION DIRECTED THROUGH BIODEGRADABLE POLYMERS.
US5591159A (en) 1994-11-09 1997-01-07 Taheri; Syde A. Transcavitary myocardial perfusion apparatus
GB9426379D0 (en) * 1994-12-23 1995-03-01 Oxford Biosciences Ltd Particle delivery
US5830430A (en) 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
US5840059A (en) 1995-06-07 1998-11-24 Cardiogenesis Corporation Therapeutic and diagnostic agent delivery
US5713863A (en) 1996-01-11 1998-02-03 Interventional Technologies Inc. Catheter with fluid medication injectors
US5925016A (en) 1995-09-27 1999-07-20 Xrt Corp. Systems and methods for drug delivery including treating thrombosis by driving a drug or lytic agent through the thrombus by pressure
CA2161863A1 (en) * 1995-10-31 1997-05-01 Michael Vivian Sefton Angiogenic material and uses thereof
EP0871512A1 (en) 1995-12-22 1998-10-21 Localmed, Inc. Localized intravascular delivery of growth factors for promotion of angiogenesis
US5810836A (en) 1996-03-04 1998-09-22 Myocardial Stents, Inc. Device and method for trans myocardial revascularization (TMR)
US5904670A (en) 1996-04-03 1999-05-18 Xrt Corp. Catheters and methods for guiding drugs and other agents to an intended site by deployable grooves
EP0806212B1 (en) 1996-05-10 2003-04-02 IsoTis N.V. Device for incorporation and release of biologically active agents
US5980545A (en) 1996-05-13 1999-11-09 United States Surgical Corporation Coring device and method
US5779721A (en) 1996-07-26 1998-07-14 Kensey Nash Corporation System and method of use for revascularizing stenotic bypass grafts and other blood vessels
US6080170A (en) * 1996-07-26 2000-06-27 Kensey Nash Corporation System and method of use for revascularizing stenotic bypass grafts and other occluded blood vessels
US5755682A (en) 1996-08-13 1998-05-26 Heartstent Corporation Method and apparatus for performing coronary artery bypass surgery
US5655548A (en) 1996-09-16 1997-08-12 Circulation, Inc. Method for treatment of ischemic heart disease by providing transvenous myocardial perfusion
DE29619029U1 (en) 1996-11-02 1997-04-10 Kletke Georg Dr Med Miocard puncture needle
US5873366A (en) 1996-11-07 1999-02-23 Chim; Nicholas Method for transmyocardial revascularization
EP0984727A4 (en) 1996-11-08 2000-05-24 Thomas J Fogarty Transvascular tmr device and method
US5766194A (en) * 1996-12-23 1998-06-16 Georgia Skin And Cancer Clinic, Pc Surgical apparatus for tissue removal
US5968059A (en) 1997-03-06 1999-10-19 Scimed Life Systems, Inc. Transmyocardial revascularization catheter and method
US6045565A (en) 1997-11-04 2000-04-04 Scimed Life Systems, Inc. Percutaneous myocardial revascularization growth factor mediums and method
US6086582A (en) * 1997-03-13 2000-07-11 Altman; Peter A. Cardiac drug delivery system
US6443949B2 (en) * 1997-03-13 2002-09-03 Biocardia, Inc. Method of drug delivery to interstitial regions of the myocardium
CA2259914C (en) 1997-05-08 2007-12-18 C.R. Bard, Inc. Tmr stent and delivery system
US5935119A (en) 1997-08-06 1999-08-10 United States Surgical Corporation Perfusion structure
EP0903132A1 (en) 1997-09-22 1999-03-24 Andreas Maurer Colour eyeglasses
US5980548A (en) * 1997-10-29 1999-11-09 Kensey Nash Corporation Transmyocardial revascularization system
US6056743A (en) 1997-11-04 2000-05-02 Scimed Life Systems, Inc. Percutaneous myocardial revascularization device and method
US6416490B1 (en) 1997-11-04 2002-07-09 Scimed Life Systems, Inc. PMR device and method
US6764461B2 (en) 1997-12-01 2004-07-20 Scimed Life Systems, Inc. Catheter system for the delivery of a low volume bolus
WO1999033510A1 (en) 1997-12-31 1999-07-08 Hydrocision, Inc. Fluid jet cutting system for cardiac applications
WO1999044524A2 (en) 1998-03-05 1999-09-10 Scimed Life Systems, Inc. Expandable pmr device and method
US6406455B1 (en) * 1998-12-18 2002-06-18 Biovalve Technologies, Inc. Injection devices
US6689103B1 (en) * 1999-05-07 2004-02-10 Scimed Life System, Inc. Injection array apparatus and method
US6319230B1 (en) * 1999-05-07 2001-11-20 Scimed Life Systems, Inc. Lateral needle injection apparatus and method
WO2000067837A1 (en) 1999-05-10 2000-11-16 Gentronics, Inc. Method of electroporation-enhanced delivery of active agents
US7147633B2 (en) * 1999-06-02 2006-12-12 Boston Scientific Scimed, Inc. Method and apparatus for treatment of atrial fibrillation
ATE342089T1 (en) * 1999-06-02 2006-11-15 Boston Scient Ltd DRUG DELIVERY DEVICES
US6709427B1 (en) * 1999-08-05 2004-03-23 Kensey Nash Corporation Systems and methods for delivering agents into targeted tissue of a living being
US6344027B1 (en) * 1999-12-08 2002-02-05 Scimed Life Systems, Inc. Needle-less injection apparatus and method

Also Published As

Publication number Publication date
US7419482B2 (en) 2008-09-02
DE60041196D1 (en) 2009-02-05
WO2001010313A1 (en) 2001-02-15
US20100094196A1 (en) 2010-04-15
EP1206219B1 (en) 2008-12-24
US6709427B1 (en) 2004-03-23
US7594900B1 (en) 2009-09-29
CA2381153C (en) 2007-11-27
AU6611200A (en) 2001-03-05
JP2003506131A (en) 2003-02-18
US20030191449A1 (en) 2003-10-09
US20040158227A1 (en) 2004-08-12
JP3712668B2 (en) 2005-11-02
EP1206219A1 (en) 2002-05-22

Similar Documents

Publication Publication Date Title
CA2381153A1 (en) System and method for delivering agents into targeted tissue of a living being
US7776025B2 (en) Method for providing medicament to tissue
USRE42959E1 (en) Apparatus and methods for stimulating revascularization and/or tissue growth
US6464680B1 (en) Ultrasonic enhancement of drug injection
US7901359B2 (en) Ultrasound energy driven intraventricular catheter to treat ischemia
US6443974B1 (en) Electromagnetic cardiac biostimulation
US6221071B1 (en) Rapid electrode deployment
EP0934728A2 (en) Selective treatment of endocardial/myocardial boundary
CA2307865A1 (en) Transmyocardial revascularization system
EP0853921A2 (en) Laser assisted drug delivery
WO2002053205A3 (en) Systems and methods for delivering a probe into tissue
EP0196519A3 (en) Method and apparatus for transmyocardial revascularization using a laser
WO2003086502A3 (en) Devices and methods for transluminal or transthoracic interstitial electrode placement
CA2456626A1 (en) Microstructures for delivering a composition cutaneously to skin using rotatable structures
EP1602339A1 (en) Devices, systems, and methods for treating atrial fibrillation
CA2262588A1 (en) Electromagnetic cardiac biostimulation
CA2312142A1 (en) Injection system for gene delivery
EP1296605B1 (en) Device for myocardial revascularization
WO2002024248A1 (en) Systems and methods for delivering beneficial agents into targeted tissue of a living being
AU782484B2 (en) Methods and apparatus for delivering medicament to tissue
US6149649A (en) Radio frequency transmyocardial revascularization channel formation
WO2000002612A3 (en) Medical device and method for transmyocardial revascularization
AU9409698A (en) Selective treatment of endocardial/myocardial boundary
CA2413269A1 (en) Injection system for gene delivery

Legal Events

Date Code Title Description
EEER Examination request