CA2363071A1 - Injection molding process for neutral and acid-group containing (meth)acrylate copolymers - Google Patents

Injection molding process for neutral and acid-group containing (meth)acrylate copolymers Download PDF

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Publication number
CA2363071A1
CA2363071A1 CA002363071A CA2363071A CA2363071A1 CA 2363071 A1 CA2363071 A1 CA 2363071A1 CA 002363071 A CA002363071 A CA 002363071A CA 2363071 A CA2363071 A CA 2363071A CA 2363071 A1 CA2363071 A1 CA 2363071A1
Authority
CA
Canada
Prior art keywords
weight
meth
mixture
mould
copolymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002363071A
Other languages
French (fr)
Other versions
CA2363071C (en
Inventor
Hans-Ulrich Petereit
Thomas Beckert
Manfred Assmus
Werner Hoess
Wolfgang Fuchs
Hartmut Schikowsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2363071A1 publication Critical patent/CA2363071A1/en
Application granted granted Critical
Publication of CA2363071C publication Critical patent/CA2363071C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/077—Manufacturing capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/0001—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor characterised by the choice of material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Abstract

The invention relates to a process for producing mouldings by injection moulding, the steps in the process being A) Melting a mixture made from a) a (meth)acrylate copolymer composed of from 40 to 100% by weight of free-radical-polymerized C1-C4-alkyl esters of acrylic or methacrylic acid and from 0 to 60% by weight of (meth)acrylate monomers having an anionic group in the alkyl radical, where the copolymer comprises b) from 0.1 to 3% by weight of a release agent, and, where appropriate, the mixture may comprise c) from 0 to 50% by weight of a drier, d) from 0 to 30% by weight of a plasticizer, e) from 0 to 100% by weight of additives or auxiliaries, f) from 0 to 100% by weight of an active pharmaceutical ingredient, g) from 0 to 20% by weight of another polymer or copolymer, where the amounts given for components b) to g) are based on the (meth)acrylate copolymer a) and the mixture prior to melting has a content of more than 0.5% by weight of low-boiling constituents with vapour pressure of at least 1.9 bar at 120°C, B) Devolatilizing the mixture in the thermoplastic state at temperatures of at least 120°C, thereby lowering to not more than 0.5% by weight the content of the low-boiling constituents with vapour pressure of at least 1.9 bar at 120°C, C) Injecting the molten and devolatilized mixture into the mould cavity of an injection mould, the temperature of the mould cavity being below the glass transition temperature of the (meth)acrylate copolymer by at least 10°C, cooling the molten mixture, and removing the resultant moulding from the mould.
CA002363071A 1999-12-17 2000-12-09 Injection molding process for neutral and acid-group containing (meth)acrylate copolymers Expired - Fee Related CA2363071C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19961334A DE19961334A1 (en) 1999-12-17 1999-12-17 Injection molding process for neutral and acid group-containing (meth) acrylate copolymers
DE19961334.6 1999-12-17
PCT/EP2000/012467 WO2001043935A2 (en) 1999-12-17 2000-12-09 Injection molding method for neutral and acidic-group containing (meth)acrylate copolymers

Publications (2)

Publication Number Publication Date
CA2363071A1 true CA2363071A1 (en) 2001-06-21
CA2363071C CA2363071C (en) 2009-03-10

Family

ID=7933336

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002363071A Expired - Fee Related CA2363071C (en) 1999-12-17 2000-12-09 Injection molding process for neutral and acid-group containing (meth)acrylate copolymers

Country Status (18)

Country Link
US (2) US20020160042A1 (en)
EP (1) EP1150820B1 (en)
JP (1) JP2003516881A (en)
KR (1) KR100810919B1 (en)
CN (1) CN1378499A (en)
AT (1) ATE262401T1 (en)
AU (1) AU2364001A (en)
BG (1) BG64935B1 (en)
BR (1) BR0008258A (en)
CA (1) CA2363071C (en)
DE (2) DE19961334A1 (en)
ES (1) ES2214341T3 (en)
IL (1) IL144833A (en)
MX (1) MXPA01008224A (en)
PL (1) PL196144B1 (en)
SK (1) SK11752001A3 (en)
TR (2) TR200400862T4 (en)
WO (1) WO2001043935A2 (en)

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Publication number Priority date Publication date Assignee Title
EP3193842A4 (en) * 2014-09-19 2018-05-16 Board of Regents, The University of Texas System Methods of preparing extrudates

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Publication number Priority date Publication date Assignee Title
EP3193842A4 (en) * 2014-09-19 2018-05-16 Board of Regents, The University of Texas System Methods of preparing extrudates

Also Published As

Publication number Publication date
ES2214341T3 (en) 2004-09-16
DE50005789D1 (en) 2004-04-29
EP1150820A1 (en) 2001-11-07
US20020160042A1 (en) 2002-10-31
WO2001043935A2 (en) 2001-06-21
DE19961334A1 (en) 2001-06-21
CN1378499A (en) 2002-11-06
EP1150820B1 (en) 2004-03-24
BG64935B1 (en) 2006-10-31
WO2001043935A3 (en) 2002-04-18
ATE262401T1 (en) 2004-04-15
KR20010102218A (en) 2001-11-15
US20080260814A1 (en) 2008-10-23
KR100810919B1 (en) 2008-03-10
IL144833A0 (en) 2002-06-30
TR200102392T1 (en) 2002-11-21
MXPA01008224A (en) 2002-04-24
CA2363071C (en) 2009-03-10
BR0008258A (en) 2001-12-11
PL196144B1 (en) 2007-12-31
SK11752001A3 (en) 2002-08-06
AU2364001A (en) 2001-06-25
PL349961A1 (en) 2002-10-21
BG105799A (en) 2002-04-30
IL144833A (en) 2005-08-31
TR200400862T4 (en) 2004-06-21
JP2003516881A (en) 2003-05-20

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Effective date: 20141209