CA2319446A1 - Radiopaque implantable collagenous biomaterial device - Google Patents
Radiopaque implantable collagenous biomaterial device Download PDFInfo
- Publication number
- CA2319446A1 CA2319446A1 CA002319446A CA2319446A CA2319446A1 CA 2319446 A1 CA2319446 A1 CA 2319446A1 CA 002319446 A CA002319446 A CA 002319446A CA 2319446 A CA2319446 A CA 2319446A CA 2319446 A1 CA2319446 A1 CA 2319446A1
- Authority
- CA
- Canada
- Prior art keywords
- submucosa
- implantable biomaterial
- biomaterial
- implantable
- radiopaque marker
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/38—Stomach; Intestine; Goblet cells; Oral mucosa; Saliva
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/005—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/005—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
Abstract
Disclosed is a medical device. Specifically, a radiopaque implantable biomaterial device is provided. In one aspect, the device comprises a collagenous biomaterial derived from tissue submucosa having a biotropic agent, the biotropic agent comprising at least one of a proteoglycan, growth factor, glycoprotein, or glycosaminoglycan disposed thereon; and a radiopaque marker disposed on the collagenous biomaterial.
Claims (35)
1. A radiopaque implantable biomaterial (5) device, comprising:
a collagenous biomaterial (10) having a biotropic agent (11), the biotropic agent (11) comprising at least one of a proteoglycan, growth factor, glycoprotein, and glycosaminoglycan disposed thereon; and a radiopaque marker (16) disposed on the collagenous biomaterial (10).
a collagenous biomaterial (10) having a biotropic agent (11), the biotropic agent (11) comprising at least one of a proteoglycan, growth factor, glycoprotein, and glycosaminoglycan disposed thereon; and a radiopaque marker (16) disposed on the collagenous biomaterial (10).
2. The implantable biomaterial device (5) of claim 1 wherein the collagenous biomaterial (10) comprises tissue submucosa.
3. The implantable biomaterial device (5) of claim 2 wherein the tissue submucosa (10) comprises at least one of a porcine, bovine, and ovine submucosa.
4. The implantable biomaterial device (5) of claim 3 wherein the tissue submucosa (10) further comprises the submucosa from at least one of an alimentary, genital, urinary, respiratory, and integumentary submucosa.
5. The implantable biomaterial device (5) of claim 1 further comprising a pharmacologic agent (22) disposed on the collagenous biomaterial (10).
6. The implantable biomaterial device (5) of claim 1 wherein the radiopaque marker (16) further comprises at least one of tantalum, barium, iodine, and bismuth, and a derivative thereof.
7. The implantable biomaterial device (5) of claim 1 wherein the radiopaque marker (16) is disposed on a serosal side (18) of a tissue submucosa (10).
8. The implantable biomaterial device (5) of claim 7 wherein the radiopaque marker (16) comprises tantalum.
9. The implantable biomaterial device (5) of claim 1 wherein the radiopaque marker (16) comprises at least one of barium sulphate, iodine, and bismuth oxychloride (16).
10. The implantable biomaterial device (5) of claim 1 wherein the radiopaque marker (16) is disposed on a tissue submucosa (10).
11. The implantable biomaterial device (5) of claim 10 wherein the tissue submucosa (10) comprises a warm blooded vertebrate submucosa.
12. The implantable biomaterial device (5) of claim 11 wherein the tissue submucosa (10) comprises warm blooded vertebrate submucosa from at least one of an alimentary, genital, urinary, respiratory, and integumentary submucosa.
13. The implantable biomaterial device (5) of claim 1 wherein the collagenous biomaterial (10) comprises a collagenous biocompatible biomaterial.
14. The implantable biomaterial device (5) of claim 13 wherein the radiomarker (16) comprises tantalum powder and the collagenous biomaterial (10) comprises a warm blooded vertebrate submucosa from at least one of an alimentary, genital, urinary, respiratory, and integumentary submucosa.
15. The implantable biomaterial device (5) of claim 14 wherein the biomaterial (10) has at least one of coiled, helical, spring-like, randomized, branched, sheet-like, tubular, spherical, and fragmented shape (13).
16. The implantable biomaterial device (5) of claim 15 wherein the biomaterial (10) comprises at least one of a fluidized, comminuted, liquefied, suspended, gel-like, injectable, powdered, ground, sheared, and solid shape (13).
17. The implantable biomaterial device (5) of claim 16 further comprising an injectable (13), coiled (13), biocompatible collagenous biomaterial (10) having a tantalum powder radiopaque marker (16) disposed thereon.
18. The implantable biomaterial device (5) of claim 1 wherein the device comprises at least one of coiled, helical, spring-like, randomized, branched, sheet-like, tubular, spherical, and fragmented shape (13).
19. A radiopaque implantable biomaterial device (5), comprising:
a warm blooded vertebrate tissue submucosa (10); and a radiopaque marker (16) disposed on the tissue submucosa (10).
a warm blooded vertebrate tissue submucosa (10); and a radiopaque marker (16) disposed on the tissue submucosa (10).
20. The implantable biomaterial device (5) of claim 19 wherein the warm blooded vertebrate submucosa (10) comprises at least one of bovine, porcine, and ovine submucosa (10).
21. The implantable biomaterial device (5) of claim 20 wherein the tissue submucosa (10) further comprises the submucosa (10) from at least one of an alimentary, genital, urinary, respiratory, and integumentary submucosa (10).
22. The implantable biomaterial device (5) of claim 21 wherein the tissue submucosa (10) further comprises a pharmacologic agent (22) disposed on the tissue submucosa (10).
23. The implantable biomaterial device (5) of claim 19 wherein the radiopaque marker (16) comprises at least one of tantalum, barium, iodine, and bismuth, and derivative thereof.
24. The implantable biomaterial device (5) of claim 23 wherein the radiopaque marker (16) comprises tantalum powder.
25. The implantable biomaterial device (5) of claim 23 wherein the radiopaque marker (16) comprises at least one of barium sulphate, iodine, and bismuth oxychloride.
26. The implantable biomaterial device (5) of claim 19 further comprising a porcine alimentary submucosa (12) including a tantalum powder radiopaque marker (16) disposed thereon.
27. The implantable biomaterial device (5) of claim 19 wherein the device has at least one of a coiled, helical, spring-like, randomized, branched, sheet-like, tubular, spherical, and fragmented shape (13).
28. The implantable biomaterial device (5) of claim 19 wherein the material comprises at least one of in the shape (13) of fluidized, comminuted, liquefied, suspended, gel-like, injectable, powdered, ground, sheared, and solid.
29. The implantable biomaterial device (5) of claim 19 wherein the device comprises a biocompatible tissue submucosa (10).
30. The implantable biomaterial device (5) of claim 29 wherein the device has an endotoxin level less than 12 endotoxin units per gram.
31. The implantable biomaterial device (5) of claim 19 wherein the device further comprises:
porcine tissue submucosa (10);
a tantalum radiopaque marker (16) disposed on the submucosa (10); and having an endotoxin level less than 12 endotoxin units per gram.
porcine tissue submucosa (10);
a tantalum radiopaque marker (16) disposed on the submucosa (10); and having an endotoxin level less than 12 endotoxin units per gram.
32. A radiopaque implantable biomaterial device (5), comprising:
a warm blooded vertebrate submucosa (10) from at least one of an alimentary, genital, urinary, respiratory, and integumentary submucosa;
the submucosa (10) shaped into a coil (28); and a tantalum powder radiopaque marker (16) disposed on the submucosa (10).
a warm blooded vertebrate submucosa (10) from at least one of an alimentary, genital, urinary, respiratory, and integumentary submucosa;
the submucosa (10) shaped into a coil (28); and a tantalum powder radiopaque marker (16) disposed on the submucosa (10).
33. The implantable biomaterial device (5) of claim 32 wherein the device comprises a biocompatible submucosa (10).
34. The implantable biomaterial device (5) of claim 33 wherein the device has an endotoxin level less than 12 endotoxin units per gram.
35. The implantable biomaterial device (5) of claim 34 wherein the device comprises a pharmacologic agent (22) disposed on the submucosa (10).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11040798P | 1998-12-01 | 1998-12-01 | |
US60/110,407 | 1998-12-01 | ||
PCT/US1999/027652 WO2000032253A1 (en) | 1998-12-01 | 1999-11-22 | Radiopaque implantable collagenous biomaterial device |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2319446A1 true CA2319446A1 (en) | 2000-06-08 |
CA2319446C CA2319446C (en) | 2010-09-14 |
Family
ID=22332849
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002319443A Expired - Lifetime CA2319443C (en) | 1998-12-01 | 1999-05-27 | Collagenous biomaterials formed with submucosal tissue |
CA2319446A Expired - Fee Related CA2319446C (en) | 1998-12-01 | 1999-11-22 | Radiopaque implantable collagenous biomaterial device |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002319443A Expired - Lifetime CA2319443C (en) | 1998-12-01 | 1999-05-27 | Collagenous biomaterials formed with submucosal tissue |
Country Status (10)
Country | Link |
---|---|
US (2) | US7713552B2 (en) |
EP (3) | EP1051206B1 (en) |
JP (1) | JP2002531181A (en) |
AT (1) | ATE301478T1 (en) |
AU (2) | AU4316399A (en) |
BR (1) | BR9908043A (en) |
CA (2) | CA2319443C (en) |
DE (2) | DE69939370D1 (en) |
DK (1) | DK1051206T3 (en) |
WO (2) | WO2000032250A1 (en) |
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1999
- 1999-05-27 EP EP99972935A patent/EP1051206B1/en not_active Expired - Lifetime
- 1999-05-27 CA CA002319443A patent/CA2319443C/en not_active Expired - Lifetime
- 1999-05-27 DK DK99972935T patent/DK1051206T3/en active
- 1999-05-27 WO PCT/US1999/011733 patent/WO2000032250A1/en active Application Filing
- 1999-05-27 EP EP08012454.8A patent/EP1985320B1/en not_active Expired - Lifetime
- 1999-05-27 JP JP2000584939A patent/JP2002531181A/en active Pending
- 1999-05-27 BR BR9908043-5A patent/BR9908043A/en not_active Application Discontinuation
- 1999-05-27 DE DE69939370T patent/DE69939370D1/en not_active Expired - Lifetime
- 1999-05-27 AU AU43163/99A patent/AU4316399A/en not_active Abandoned
- 1999-11-22 AT AT99961751T patent/ATE301478T1/en not_active IP Right Cessation
- 1999-11-22 AU AU18267/00A patent/AU1826700A/en not_active Abandoned
- 1999-11-22 DE DE69926604T patent/DE69926604D1/en not_active Expired - Lifetime
- 1999-11-22 WO PCT/US1999/027652 patent/WO2000032253A1/en active IP Right Grant
- 1999-11-22 CA CA2319446A patent/CA2319446C/en not_active Expired - Fee Related
- 1999-11-22 EP EP99961751A patent/EP1051207B1/en not_active Expired - Lifetime
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2001
- 2001-12-19 US US10/025,282 patent/US7713552B2/en not_active Expired - Fee Related
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2010
- 2010-04-19 US US12/762,796 patent/US9089626B2/en active Active
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EP1051207B1 (en) | 2005-08-10 |
WO2000032250A1 (en) | 2000-06-08 |
CA2319443A1 (en) | 2000-06-08 |
JP2002531181A (en) | 2002-09-24 |
US20100204782A1 (en) | 2010-08-12 |
EP1051207A1 (en) | 2000-11-15 |
EP1051206B1 (en) | 2008-08-20 |
EP1985320A1 (en) | 2008-10-29 |
WO2000032253A1 (en) | 2000-06-08 |
US20030206860A1 (en) | 2003-11-06 |
EP1051206A1 (en) | 2000-11-15 |
CA2319443C (en) | 2009-09-29 |
US7713552B2 (en) | 2010-05-11 |
DE69939370D1 (en) | 2008-10-02 |
AU4316399A (en) | 2000-06-19 |
AU1826700A (en) | 2000-06-19 |
US9089626B2 (en) | 2015-07-28 |
BR9908043A (en) | 2001-12-18 |
DK1051206T3 (en) | 2008-11-24 |
ATE301478T1 (en) | 2005-08-15 |
DE69926604D1 (en) | 2005-09-15 |
CA2319446C (en) | 2010-09-14 |
EP1985320B1 (en) | 2017-06-21 |
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