CA2292505A1 - Electrodes for the measurement of analytes in small sample volumes - Google Patents

Electrodes for the measurement of analytes in small sample volumes Download PDF

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Publication number
CA2292505A1
CA2292505A1 CA002292505A CA2292505A CA2292505A1 CA 2292505 A1 CA2292505 A1 CA 2292505A1 CA 002292505 A CA002292505 A CA 002292505A CA 2292505 A CA2292505 A CA 2292505A CA 2292505 A1 CA2292505 A1 CA 2292505A1
Authority
CA
Canada
Prior art keywords
conductive layer
mesh
gap
layer
analytes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002292505A
Other languages
French (fr)
Other versions
CA2292505C (en
Inventor
Stephen Charles Williams
Bernadette Yon-Hin
Neil Blair
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cambridge Sensors Ltd
Original Assignee
Cambridge Sensors Limited
Stephen Charles Williams
Bernadette Yon-Hin
Neil Blair
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cambridge Sensors Limited, Stephen Charles Williams, Bernadette Yon-Hin, Neil Blair filed Critical Cambridge Sensors Limited
Publication of CA2292505A1 publication Critical patent/CA2292505A1/en
Application granted granted Critical
Publication of CA2292505C publication Critical patent/CA2292505C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels

Abstract

A device for use in the electrochemical analysis of an analyte in a liquid sample, comprises: a non-conducting substrate (1); a conductive layer, deposited on the substrate, in two parts (2a, 2b), defining a non-conducting gap (8) therebetween; an analyte-specific reagent (5) coated on the conductive layer, on one side of the gap; a reference electrode (3) on the conductive layer, on the other side of the gap; a spacer layer (4) deposited over the conductive layer; a monofilament mesh (6) coated with a surfactant or chaotropic agent, the mesh being laid over the reagent, the reference electrode and the spacer layer; and a second non-conductive layer (7), adhered to the mesh layer, but not coextensive therewith, thereby providing a sample application area (9) on the mesh.
CA002292505A 1997-06-04 1998-06-03 Electrodes for the measurement of analytes in small sample volumes Expired - Fee Related CA2292505C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9711395.5 1997-06-04
GBGB9711395.5A GB9711395D0 (en) 1997-06-04 1997-06-04 Improvements to electrodes for the measurement of analytes in small samples
PCT/GB1998/001624 WO1998055856A1 (en) 1997-06-04 1998-06-03 Electrodes for the measurement of analytes in small sample volumes

Publications (2)

Publication Number Publication Date
CA2292505A1 true CA2292505A1 (en) 1998-12-10
CA2292505C CA2292505C (en) 2007-05-15

Family

ID=10813465

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002292505A Expired - Fee Related CA2292505C (en) 1997-06-04 1998-06-03 Electrodes for the measurement of analytes in small sample volumes

Country Status (10)

Country Link
US (1) US6436256B1 (en)
EP (1) EP0986748B1 (en)
JP (1) JP4073969B2 (en)
AT (1) ATE340997T1 (en)
CA (1) CA2292505C (en)
DE (1) DE69836016T2 (en)
DK (1) DK0986748T3 (en)
ES (1) ES2273420T3 (en)
GB (1) GB9711395D0 (en)
WO (1) WO1998055856A1 (en)

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Also Published As

Publication number Publication date
US6436256B1 (en) 2002-08-20
DE69836016D1 (en) 2006-11-09
DK0986748T3 (en) 2007-01-15
DE69836016T2 (en) 2007-01-18
WO1998055856A1 (en) 1998-12-10
ES2273420T3 (en) 2007-05-01
EP0986748B1 (en) 2006-09-27
CA2292505C (en) 2007-05-15
JP4073969B2 (en) 2008-04-09
EP0986748A1 (en) 2000-03-22
ATE340997T1 (en) 2006-10-15
JP2002502500A (en) 2002-01-22
GB9711395D0 (en) 1997-07-30

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