CA2256427A1 - Intracardiac blood pump - Google Patents
Intracardiac blood pump Download PDFInfo
- Publication number
- CA2256427A1 CA2256427A1 CA002256427A CA2256427A CA2256427A1 CA 2256427 A1 CA2256427 A1 CA 2256427A1 CA 002256427 A CA002256427 A CA 002256427A CA 2256427 A CA2256427 A CA 2256427A CA 2256427 A1 CA2256427 A1 CA 2256427A1
- Authority
- CA
- Canada
- Prior art keywords
- pump
- pressure
- motor
- measuring device
- blood pump
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02K—DYNAMO-ELECTRIC MACHINES
- H02K49/00—Dynamo-electric clutches; Dynamo-electric brakes
- H02K49/10—Dynamo-electric clutches; Dynamo-electric brakes of the permanent-magnet type
- H02K49/104—Magnetic couplings consisting of only two coaxial rotary elements, i.e. the driving element and the driven element
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/10—Location thereof with respect to the patient's body
- A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
- A61M60/126—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
- A61M60/13—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel by means of a catheter allowing explantation, e.g. catheter pumps temporarily introduced via the vascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/10—Location thereof with respect to the patient's body
- A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
- A61M60/126—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
- A61M60/135—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel inside a blood vessel, e.g. using grafting
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/20—Type thereof
- A61M60/205—Non-positive displacement blood pumps
- A61M60/216—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
- A61M60/237—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller the blood flow through the rotating member having mainly axial components, e.g. axial flow pumps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/40—Details relating to driving
- A61M60/403—Details relating to driving for non-positive displacement blood pumps
- A61M60/408—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable
- A61M60/411—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable generated by an electromotor
- A61M60/414—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable generated by an electromotor transmitted by a rotating cable, e.g. for blood pumps mounted on a catheter
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/40—Details relating to driving
- A61M60/403—Details relating to driving for non-positive displacement blood pumps
- A61M60/408—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable
- A61M60/411—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable generated by an electromotor
- A61M60/416—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being mechanical, e.g. transmitted by a shaft or cable generated by an electromotor transmitted directly by the motor rotor drive shaft
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/40—Details relating to driving
- A61M60/403—Details relating to driving for non-positive displacement blood pumps
- A61M60/419—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being permanent magnetic, e.g. from a rotating magnetic coupling between driving and driven magnets
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/40—Details relating to driving
- A61M60/403—Details relating to driving for non-positive displacement blood pumps
- A61M60/422—Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being electromagnetic, e.g. using canned motor pumps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/50—Details relating to control
- A61M60/508—Electronic control means, e.g. for feedback regulation
- A61M60/515—Regulation using real-time patient data
- A61M60/531—Regulation using real-time patient data using blood pressure data, e.g. from blood pressure sensors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/50—Details relating to control
- A61M60/508—Electronic control means, e.g. for feedback regulation
- A61M60/538—Regulation using real-time blood pump operational parameter data, e.g. motor current
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/50—Details relating to control
- A61M60/585—User interfaces
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/80—Constructional details other than related to driving
- A61M60/802—Constructional details other than related to driving of non-positive displacement blood pumps
- A61M60/818—Bearings
- A61M60/825—Contact bearings, e.g. ball-and-cup or pivot bearings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/80—Constructional details other than related to driving
- A61M60/802—Constructional details other than related to driving of non-positive displacement blood pumps
- A61M60/827—Sealings between moving parts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/80—Constructional details other than related to driving
- A61M60/802—Constructional details other than related to driving of non-positive displacement blood pumps
- A61M60/827—Sealings between moving parts
- A61M60/829—Sealings between moving parts having a purge fluid supply
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/80—Constructional details other than related to driving
- A61M60/802—Constructional details other than related to driving of non-positive displacement blood pumps
- A61M60/833—Occluders for preventing backflow
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/80—Constructional details other than related to driving
- A61M60/855—Constructional details other than related to driving of implantable pumps or pumping devices
- A61M60/861—Connections or anchorings for connecting or anchoring pumps or pumping devices to parts of the patient's body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/80—Constructional details other than related to driving
- A61M60/855—Constructional details other than related to driving of implantable pumps or pumping devices
- A61M60/871—Energy supply devices; Converters therefor
- A61M60/88—Percutaneous cables
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- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02K—DYNAMO-ELECTRIC MACHINES
- H02K15/00—Methods or apparatus specially adapted for manufacturing, assembling, maintaining or repairing of dynamo-electric machines
- H02K15/14—Casings; Enclosures; Supports
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- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02K—DYNAMO-ELECTRIC MACHINES
- H02K5/00—Casings; Enclosures; Supports
- H02K5/04—Casings or enclosures characterised by the shape, form or construction thereof
- H02K5/08—Insulating casings
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- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02K—DYNAMO-ELECTRIC MACHINES
- H02K5/00—Casings; Enclosures; Supports
- H02K5/04—Casings or enclosures characterised by the shape, form or construction thereof
- H02K5/12—Casings or enclosures characterised by the shape, form or construction thereof specially adapted for operating in liquid or gas
- H02K5/124—Sealing of shafts
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- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02K—DYNAMO-ELECTRIC MACHINES
- H02K5/00—Casings; Enclosures; Supports
- H02K5/04—Casings or enclosures characterised by the shape, form or construction thereof
- H02K5/12—Casings or enclosures characterised by the shape, form or construction thereof specially adapted for operating in liquid or gas
- H02K5/128—Casings or enclosures characterised by the shape, form or construction thereof specially adapted for operating in liquid or gas using air-gap sleeves or air-gap discs
- H02K5/1285—Casings or enclosures characterised by the shape, form or construction thereof specially adapted for operating in liquid or gas using air-gap sleeves or air-gap discs of the submersible type
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- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02K—DYNAMO-ELECTRIC MACHINES
- H02K5/00—Casings; Enclosures; Supports
- H02K5/04—Casings or enclosures characterised by the shape, form or construction thereof
- H02K5/12—Casings or enclosures characterised by the shape, form or construction thereof specially adapted for operating in liquid or gas
- H02K5/132—Submersible electric motors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/18—General characteristics of the apparatus with alarm
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2207/00—Methods of manufacture, assembly or production
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/10—Location thereof with respect to the patient's body
- A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
- A61M60/126—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
- A61M60/148—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/80—Constructional details other than related to driving
- A61M60/802—Constructional details other than related to driving of non-positive displacement blood pumps
- A61M60/818—Bearings
- A61M60/824—Hydrodynamic or fluid film bearings
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- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02K—DYNAMO-ELECTRIC MACHINES
- H02K11/00—Structural association of dynamo-electric machines with electric components or with devices for shielding, monitoring or protection
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- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02K—DYNAMO-ELECTRIC MACHINES
- H02K15/00—Methods or apparatus specially adapted for manufacturing, assembling, maintaining or repairing of dynamo-electric machines
- H02K15/02—Methods or apparatus specially adapted for manufacturing, assembling, maintaining or repairing of dynamo-electric machines of stator or rotor bodies
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- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02K—DYNAMO-ELECTRIC MACHINES
- H02K21/00—Synchronous motors having permanent magnets; Synchronous generators having permanent magnets
- H02K21/12—Synchronous motors having permanent magnets; Synchronous generators having permanent magnets with stationary armatures and rotating magnets
- H02K21/14—Synchronous motors having permanent magnets; Synchronous generators having permanent magnets with stationary armatures and rotating magnets with magnets rotating within the armatures
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- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02K—DYNAMO-ELECTRIC MACHINES
- H02K7/00—Arrangements for handling mechanical energy structurally associated with dynamo-electric machines, e.g. structural association with mechanical driving motors or auxiliary dynamo-electric machines
- H02K7/14—Structural association with mechanical loads, e.g. with hand-held machine tools or fans
- H02K7/145—Hand-held machine tool
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S415/00—Rotary kinetic fluid motors or pumps
- Y10S415/90—Rotary blood pump
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49002—Electrical device making
- Y10T29/49009—Dynamoelectric machine
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
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- Y10T29/49002—Electrical device making
- Y10T29/49009—Dynamoelectric machine
- Y10T29/49012—Rotor
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
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- Y10T29/49636—Process for making bearing or component thereof
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Abstract
The invention relates to a blood pump which has a drive part (11) and a pump part (12), said pump part being extended by means of a flexible hose (13). Pressure sensors (60, 61) detect the pressure difference between the inlet end and the outlet end of the pump. The volume flow can then be determined from the pressure difference in conjunction with the rotational speed. The pressure difference can also be used to determine the correct position of the pump in the heart. Alternatively, the current consumed by the motor (21) is measured and the volume flow of the pump is calculated from this current consumption measurement, taking into account the known rotational speed. The signal of the pressure measurement device or the motor current can be used to determine the correct position of the pump in the heart.
Description
- CA 022~6427 1998-11-26 An intracardiac blood pump The invention relates to an intracardiac blood pump, and in particular to a blood pump that may be inserted entirely into the heart to assist the natural cardiac pump function or to replace the same by a continuous pumping operation.
A pump device for supporting the heart is described in W094/09835 (Jarvik). Thispump device compri~es two independent pumps each having a pump portion and a drive portion rigidly connected therewith. The pump portion of the one pump is intro-duced into the left ventricle through an operation opening at the apex of the heart such that it delivers blood from the left ventricle into the aorta. The other pump portion is introduced through another operation opening into the right ventricle such that it delivers blood from the right ventricle into the pulmonary artery. The system further comprises a control and display module that is small enough to be st~rili7ecl and used in the sterile environment of the operation. It may include a microprocessor with control and monitoring algorithms for regulating the volume flow and the pressure, or to supply the volume flow and the pressure to a data base, the values thereof having been measured by sensors or having been calculated by comparing the measurementsof velocity and energy consumption. These pumps, referred to as c~nn~ pumps, maybe equipped with built-in pressure sensors or volume flow me~llring devices to take local measurements of these parameters in the context of patient management.
It is an object of the present invention to provide an intracardiac blood pump, the operational behavior of which can be determined with simple measuring means thatrequire little additional space.
According to the invention, the object is solved with the features of claim 1.
In the blood pump of the present invention, the rotational speed of the motor is con-trolled in dependance on the pressure prevailing at the outlet side of the pump. The pressure at the delivery side of the pump is an important parameter for the output and the operating point of the pump; it may further be used to measure the volume flow, CA 022~6427 1998-11-26 that is the yield per unit of time. The motor may be controlled such that its rotational speed is varied as a function of the measurement result of the pressure measuring means.
In the context of the present invention, the term "intracardiac" is meant to refer to the ventricles, the vestibules and the adjacent vascular stumps.
The pressure measuring means may further be used to ~leterrnine the position of the pump in the heart.
Suitably, the pressure measuring means comprises two pressure sensors, one of which measures the pressure at the delivery side of the pump, while the other measures the pl~s~ule at the inlet side ofthe pump, the control unit controlling the rotational speed of the motor as a function ofthe signals from both pressure sensors. Using the pressure sensors, the differential pressure between the intake side and the delivery side of the pump is determined. From the differential ples~ule of the pump and the rotational speed of the motor, the volume flow may be calculated with the use of a hydraulic characteristic pumping diagram of the pump. Thus, the volume flow delivered by the pump is obtained from a very simple measurement, with the sensors requiring verylittle space.
Instead of two pressure sensors, a single differential pL~Ule sensor may be provided that measures the di~lcll~ial pressure between the delivery side and the intake side of the pump. Such a differential pressure sensor does not provide an absolute pressure val-ue, but rather yields a value of the differential pressure which is the essential value for cletetrnining the volume flow. On the other hand, such a diLL'~;lelllial pressure sensor may at the same time be used for locating the pump within the heart.
The pressure measuring means need not~have one or more pressure sensors. Rather, the pressure may also be determined indirectly via a current measuring means that mea-CA 022~6427 1998-11-26 sures the motor current and calculates the differential pres~ between the delivery side and the intake side of the pump from the motor current and the rotational speed.
The present invention further relates to an intracardiac blood pump offering thepossibility to monitor the positioning of the pump in the heart without requiring any x-ray control for that purpose. A blood pump of this type is defined in claim 6. A measur-ing means provides an information signal corresponding to the differential pressure between the delivery side and the intake side of the pump. On a display device, either the information signal or a signal derived therefrom or information on the correct positioning of the pump in the heart are displayed. Here, use is made of the fact that a differential pressure between two different locations of the pump-can occur only, if between these two locations, there is an element enclosing the pump, e.g. a cardiac valve. As long as there is no differential pressure between these two locations, the pump as a whole is in the same space. A dirr~ lial pressure will appear only when a part of the pump is in another space. Due to this fact, the position of he pump may be determined by simple means.
Preferably, the pump is designed as an intravascular pump as described in W097/376-96 (published posteriorly). Such an intravascular blood pump is connected to a catheter.
It is small enough to be pushed through a blood vessel to the place where it is int~-ntled to work, or it may also be operated in the blood vessel. In an intravascular blood pump of this type, the pump portion and the drive portion have substantially the same diame-ter of no more than about 5 - 7 mm, since the vessel width in peripheral regions of the body is slightly larger than 7 mm at most. The rigid length of such a pump must not be greater than about 35 mm so that the pump can manage to pass through bends of blood vessels. However, the pump may fu~ther be prolonged by means of a flexible hose that increases the effective length of the pump.
On the other hand, it is possible to surgi~ally introduce the pump into the heart via the vessel system near the heart. In any case, the pump is small enough to fit into the heart, CA 022~6427 1998-11-26 including the vestibules and the adjacent vascular stumps, and to be operated in the heart without parts of the pump e~ten(1in~ from the heart. If any, the catheter connected to the pump is lead out from the heart. This catheter not only includes the lines for supplying electric energy to the pump, but also the signal lines leading from the sensors of the pump to the extracorporeal conkol unit.
The following is a detailed description of embotliments of the present invention taken in conjunction with the acco~ llyillg.drawings.
In the Figures:
Fig. 1 illustrates a ~ehem~tic l~ngitll~lin~l section of one embodiment of an intracardiac blood pump, Fig. 2 shows an embodiment of the intracardiac implement~tion of two intravascular pumps, Fig. 3 is a s~hems~tic diagram for explaining a pump system, Fig. 4 is a diagram for showing the dependance of the volume flow on the differential pressure between the intake side and the delivery side of a pump, Fig. S shows a diagrarn of the variation in time of di~el~ell~ pressures in the heart, Fig. 6 illustrates a longitll~1in~1 section of a part of the blood pump comprising a differential pressure sensor, and Fig. 7 is a ~ m for showing the dependance of the volume flow on the motor current and the rotational speed. ~
CA 022~6427 1998-11-26 Fig. 1 shows an intravascular blood pump 10, i.e. a blood pump that may be pushed through the blood vessel system of a patient to eventually arrive in the heart. The outer diameter of such a pump is nowhere larger than 7 mm.
The pump 10 comprises a drive portion 11 and a rigidly connected pump portion 12.
The drive portion 11 has an elongated cylindrical housing 20 accommodating an electric motor 21. At the rear end, the housing 20 is closed with an end wall 22 which is followed by a flexible catheter 14 sealing the same. The electric lines 23 for power supply and for controlling the electric motor 21 and further lines 23a connected to the sensors of the pump 10 extend through this catheter 14.
As is typical, the stator 24 of the motor has a plurality of circumferentially distributed coils and a magnetic yoke arranged in the longitudinal direction. It is firmly connected to the motor housing 20. The stator 24 surrounds the rotor 26 that is connected with the motor shaft 25 and is made of perm~nent magnets magnetized in the effective/active direction. A bearing 27 supports the rear end of the motor shaft in the motor housing or the end wall 22. The motor shaft extends throughout the entire length of the motor housing 20 and projects therefrom to the front.
The front closure of the motor housing is formed by a tubular stationary hub member 30 having its rear end located in a reduced diameter projection 20a of the housing 20.
The outer diameter of the hub member tapers towards the front end where a bearing 33 for supporting the motor shaft 25 is situated. This bearing is ~imlllt~neously designed as a shaft seal.
The motor shaft 25 protrudes forward from the hub member 30, where it carries animpeller wheel 34 with a hub 35 sitting on the shaft end and blades 36 or pump vanes protruding therefrom and being oblique with respect to the axis of the impeller wheel 34. The impeller wheel 34 is accommQdated in a cylindrical pump housing 32 con-nected with the motor housing 20 by three circumferentially distributed webs 38. The ~ CA 022~6427 1998-11-26 .
motor housing 20 and the pump housing 32 are rigidly interconnected by means of a ring 38 and have equal outer diameters. The dialneter ofthe purnp 10 is nowhere larger than this outer diameter.
When the impeller wheel 34 rotates, blood is drawn through the intake opening 37 of the pump housing 32 and forced rearward in the axial direction in the pump housing 32.
Through the annular gap between the pump housing 32 and the motor housing 20, blood flows outward along the hub member 30 to further flow along the motor housing 20. Thereby, the heat generated in the drive is carried away without the blood being damaged by excessively high surface tempc~dtul~s (above 41~ C) on the motor housing 20.
It is also possible to design the pump portion 12 for the opposite delivery direction, the blood being drawn along the motor housing and being discharged axially at the front end opening 27.
Fig. 2 illustrates an embodiment wherein two generally identical pumps lOa, lOb,configured as illustrated in Fig. 1, are used in a heart to support the heart or as a substi-tute for the pumping function of the heart when the heart is immobilized. Both pumps lOa, lOb are connected with a catheter 14a, 14b, respectively. They have been placed percutaneously, the catheter 14a of the left cardiac pump lOa e~rt~ntling through the aorta 40 and a hose 13 prolongating the pump lOa being advanced into the left ventricle 42 through the aortic valve 41. Here, the pump portion 12 is prolongated by the flexible hose 13 connected with the pump housing 32, the end and/or the side wall of the hose being provided with openings for blood to enter into the pump lOa. The pump lOa takes in through the hose 13 and delivers blood into the aorta 40, while the aortic valve 41 abuts on the pump housing 32 or the hose 13 from outside. Thus, in the left ventricle 42, the pump 1 Oa is operated as a left heart pump with axial intake.
, CA 022~6427 1998-11-26 The other pump 1 Ob is operated as a right heart pump in fluid conllllullication with the right ventricle 43. The catheter 14b passes through the upper or the lower vena cava 44 into the right atrium 45. The hose 13 of the pump lOb projects through the tricuspidal valve 43a and the pulmonary valve 46 into the pulmonary artery 47 from where theblood flows to the lung 48 for oxygenizing. The oxygenized blood the flows into the left vestibule 49 and on into the left ventricle 42.
The pump 1 Ob takes in through the radial inlet 50 and conveys blood through the hose 13 axially into the plllm~n~ry artery 47. Thus, the pump 10b is operated inversely to the pump lOa.
Both pumps lOa, lOb are introduced into the heart without one of the ventricles having to be surgically opened.
Fig. 3 is a schematic illustration of the two pumps lOa, lOb with different sensors.
Specifically, the outer surface of the drive unit 11 is provided with a first pressure sensor 60 located close to the radial opening 51, whereas a second pressure sensor 61 is arranged near the inlet of the pump housing. The lines 23a of the sensors are inte-grated into the elemen1~.~ of the pump and extend through the catheter 14 together with the supply lines 23. The sensor surface of the pressure sensor 60 is on the exterior of the motor housing. Conversely, the sensor face of the pl~;S~ sensor 61 is provided on the inner surface of the hose 13. Further, a temperature sensor may be provided at the drive portion for monitoring the motor temperature.
Similarly, in the pump lOb, a first pressure sensor 62 is provided on the outer surface of the motor housing and a further pressure sensor 63 is provided on the inner surface of the hose 13. The lines of these sensors also extend through the catheter 14. The catheter 14 is provided with an oxygen sensor 64 providing information on the oxygen-ation of the blood.
CA 022~6427 1998-11-26 The supply lines 23 and the lines 23a are connected with an extracorporeal interface 65,. This int~rf~ce supplies the signals from the sensors to a control unit 66 that evalu-ates these signals and controls the pumps la, 10b in dependence thereon. A keypad and display device 67 is connected with the control unit 66 to allow for information to be entered and displayed.
Using the information supplied by the sensors, it is possible to determine the position of a pump relative to an external enclosing member, e.g. a cardiac valve. When the pump inlet and the pump outlet are on different sides of the enclosing member, adifferential pressure will appear at the pressure sensors due to the different pressure conditions. When the heart beats, this differential pressure also varies in time. On the other hand, equal measured pressure values indicate an incorrect positioning of the pump because both pleS~ sensors measure the same pl~s~ule. The evaluation of the data supplied by the two plt;~ule sensors, with consideration to the motor current, provides important information on the positioning and the operation of the pump. By comparing the differential pressure to the momentaneous motor current, it is also possible to clet~rrnine blocking conditions or cavitation.
Information on the inlet and outlet pl1S~ ;;S of the pump, together with the energy consumption of the electric motor, provide important statements on the functioning of a pump device. They also supply a real time indication on the volume flow and allow for the pump to be positioned without x-ray or ultrasonic control. Moreover, a real time monitoring of an impeded inlet flow can be effected, as may be caused, e.g., by a collapse of the ventricle, thrombogenesis, occlusion of the hose or by cardiac tissue being drawn in. Further, the sensors make it possible to monitor the wearing of bear-ings, of failures of the motor or to predict such events. Furthermore, the operation of the pump can be m~int~ined with acceptable total hemolysis rates for the required period of use and with the required volume flow of 3.6 to 5 l/min. The performance trends of various parameters may be~displayed and analyzed for several hours of operation, with alarm conditions that require immediate intervention being detected CA 022~6427 1998-11-26 without nece~it~tin~ perm:~nent control by personnel. Further, the heart of a patient can be monitored without removing the pump. When placing two instrumented pumps, to supply the control unit with the local information provided by one pump so as tocontrol the operation of the other pump, thereby optimi7ing the performance of the overall system.
The control unit 66 controls both pumps lOa, lOb such that each pump delivers a certain volume flow (volume of blood per unit time). In doing so, the right heart pump lOb pumps a predetermined percentage of the volume flow of the left heart pump lOa, for example 90%. The volume flow of the right heart pump is always smaller than that of the left heart pump. Primarily, the pumping capacity of the left heart pump lOa is controlled such that a predetermined volume flow is m~int~ined. Subsequently, the g capacity ofthe right heart pump lOb is d~ "~ ed as a function thereof. This is a master-slave operation, where usually the left heart pump lOa is the master and the right heart pump 1 Ob is the slave.
The pumps are driven by synchronous motors, with the control unit 66 supplying the required drive frequency or rotational speed n. The volume flow of each pump is a function of the rotational speed n.
Fig. 4 illustrates the volume flow V of a pump in dependance on the dirre;iellLial ples:~u~ P between the intake side and the delivery side of the pump for respective different rotational speeds n. Each parallel straight line relates to a specific rotational speed n. It is evident that the volume flow V may be calculated from the differential pressure l~P when the rotational speed n is known. The motor 21 is an electronically col ""I~ d synchronous motor. Since the rotational speed is preset by the control unit, the rotational speed is known. The differential pressure ~P is det~rmined by means of the sensors 60 and 61 or 62 and 63, respectively. Moreover, of course, the absolute values of the pressures are measured an~d evaluated as well.
CA 022~6427 1998-11-26 When a pump takes in through the radial intake opening 50 or 51 and delivers into the hose 13, the pressure at the hose-side pressure sensor 61 or 63 is greater than at the intake-side pressure sensor 60 or 62. However, when the pump pumps in the opposite direction, i.e. when it takes in through the hose 13, the pressure at the pressure sensor 60 or 62 is greater than the pressure at the pressure sensor 61 or 63, respectively.
It can happen that one of the pumps is entirely or partly occluded by the pump getting sucked to cardiac tissue or the valve a~aL~ ,. In this case, the pressure sensors supply abnormal values. The rotational speed of the respective pump will then be reduced for a ceratin time so that the cardiac tissue may disengage itself, and, subsequently, the rotational speed will be increased again to the desired number. When the measured absolute ple'7~ becomes too high, the control unit 66 will effect a limitation - and, if need be, a reduction - of the volume flow to avoid damage to downstream organs (lungs).
Measuring the pressure also provides a watch function. The pressure in the rightventricle or in the pulmonary artery must not exceed a certain value, and the pressure in the left ventricle or in the aorta must not fall below a certain pLeS~iule~ When corre-sponding pressure deviations are (1etecte~l an alarm is emitted or an adjustment is effected.
Fig. 5 illustrates the pl~s~ult; variation pl in the left ventricle of the beating heart with the systoles S and the diastoles D. One can see a strongly p~ ting pressure that drops sharply between systoles S. Moreover, the pressure variation p2 in the aorta is illus-trated. The aortic pressure may also pulsate, yet it does so in a much narrower pressure range. The dirreLc;lllial pressure ~P is ~leterrnined from p2 - pl. This differential pressure may be determined with the pressure sensors provided on the pumps.
Mc~lrin~ the pressures and the differe~tial pressures is important in particular for the insertion of the pump into the correct position in the heart. The insertion may be done CA 022~6427 1998-11-26 with the pump at a standstill or running at a low rotational speed while the heart is beating. When one pressure sensor detects the strongly pulsating pressure variation p 1 and the other detects the weakly pulsating pl~S~ variation p2, the purnp is positioned correctly.
However, measuring the pressure is not necessary for positioning. Rather, the position-ing may also be monitored by means of the current variation of the pump. As long as the inlet and the outlet of a pump are in the same space, both are subjected to the same X~Ule. If the pump is driven with a certain rotational speed, the variation in time of the pump current is constant. If, however, the outlet and the inlet of the pump are in different spaces with pressures varying in time, no smooth, but a p~ ting pump current will be obtained. Thus, it can be determined on the basis of the pump current, whether the cardiac valve correctly encloses the pump housing or the hose so that the inlet of the pump is located in the ventricle or the vestibule and the outlet is in the aorta or the pulmonary artery.
The sensors 61, 62 described above are absolute plc;s~ul~ sensors. Fig. 6 illustrates an embodiment compri~inp~ a differential pressure sensor 70 arranged in an opening 71 in the wall of the pump housing 32. The differential pressure sensor 70 has a flexible membrane 72 carrying electric resi~t~nce elements (not illustrated), the resistance of which depends on the deform~-ti- n of the membrane 72. When the pump takes in via the opening 37, the inlet pressure of the pump acts on the lower surface of the mem-brane 72. The outlet pressure of the pump acts on the outer surface of the membrane 72.
It is assumed that a cardiac valve 73 abuts against the outside of the hose 13. When the hose 13 is passed through the cardiac valve 73, a differential ~les~ult; occurs at the di~lelllial pressure sensor 70. If, however, the entire pump is in the same chamber, no substantial di~el~lllial pressure occurs at the pres~ sensor. By evaluating the signal from the differential pressure sensor 70, one may thus determine, whether the blood pump is in the correct position. .
CA 022~6427 1998-ll-26 However, determinin~ the position of the blood pump in the heart does not require a pressure measuring device at all. All that is needed is a measuring device that supplies an information signal corresponding to the dirr~;lelllial pressure between the outlet side and the inlet side of the pump. This me~nring device may be a device measuring the motor current of the motor driving the pump. The diagram of Fig. 7, similar to that of Fig. 4, illustrates the volume flow V of a pump as a function of the current I of the motor driving this pump for dirr~l~lll rotational speeds n, respectively. Each of the parallel straight lines relates to a certain rotational speed n. It is evident that the volume flow V may be tlet~rmined from the amount of the current I, when the rotational speed n is known. Thus, the volume flow V may be cleterrnined by simply measuring the current. Moreover, the correct position of the pump in the heart can also be verified by measuring the current.
When the heart is beating and the blood pump is positioned as the blood pump 10a shb-wn in Fig. 2, the pulsating pressure cleci n~tetl Pl in Fig. 5 is caused in the ventricle 42 at the inlet of the blood pump. On the other hand, the less pl~ tin~ pressure P2 of Fig.
S is generated at the pump outlet. In this case, the differential pressure ~\P is a pnl~sltinp value. If, on the other hand, the blood pump is entirely located in the aorta, the pressure difference between the inlet and the outlet of the pump is substantially zero. The same is true when the blood pump is entirely located in the left ventricle 42. Thus, by mea-suring the plll~tinp~ dirrelel,lial pressure l\P (Fig. S), the correct position of the pump may be determined.
Comparing the diagrams of Figs. 4 and 7, it is evident that, for constant rotational speeds, the current I consumed by the motor is proportional to the differential pressure l\P. If a plll.~tinp dirrel~;nlial pressure ~P is obtained, the motor current I is also plll~tin~ Thus, the pulsation of the motor current I helps in determinin~, when the correct pump position is reached. In this case, the variation of the current I may be used as an information signal. .
The invention allows to control the pump operation so as to obtain a desired volume flow as a function of the result of a pressure measurement or the result of a current measurement. These measurements may be taken in a very simple manner without voluminous measuring devices so that the operation of the pump may be accuratelymonitored, despite the compact structure.
A pump device for supporting the heart is described in W094/09835 (Jarvik). Thispump device compri~es two independent pumps each having a pump portion and a drive portion rigidly connected therewith. The pump portion of the one pump is intro-duced into the left ventricle through an operation opening at the apex of the heart such that it delivers blood from the left ventricle into the aorta. The other pump portion is introduced through another operation opening into the right ventricle such that it delivers blood from the right ventricle into the pulmonary artery. The system further comprises a control and display module that is small enough to be st~rili7ecl and used in the sterile environment of the operation. It may include a microprocessor with control and monitoring algorithms for regulating the volume flow and the pressure, or to supply the volume flow and the pressure to a data base, the values thereof having been measured by sensors or having been calculated by comparing the measurementsof velocity and energy consumption. These pumps, referred to as c~nn~ pumps, maybe equipped with built-in pressure sensors or volume flow me~llring devices to take local measurements of these parameters in the context of patient management.
It is an object of the present invention to provide an intracardiac blood pump, the operational behavior of which can be determined with simple measuring means thatrequire little additional space.
According to the invention, the object is solved with the features of claim 1.
In the blood pump of the present invention, the rotational speed of the motor is con-trolled in dependance on the pressure prevailing at the outlet side of the pump. The pressure at the delivery side of the pump is an important parameter for the output and the operating point of the pump; it may further be used to measure the volume flow, CA 022~6427 1998-11-26 that is the yield per unit of time. The motor may be controlled such that its rotational speed is varied as a function of the measurement result of the pressure measuring means.
In the context of the present invention, the term "intracardiac" is meant to refer to the ventricles, the vestibules and the adjacent vascular stumps.
The pressure measuring means may further be used to ~leterrnine the position of the pump in the heart.
Suitably, the pressure measuring means comprises two pressure sensors, one of which measures the pressure at the delivery side of the pump, while the other measures the pl~s~ule at the inlet side ofthe pump, the control unit controlling the rotational speed of the motor as a function ofthe signals from both pressure sensors. Using the pressure sensors, the differential pressure between the intake side and the delivery side of the pump is determined. From the differential ples~ule of the pump and the rotational speed of the motor, the volume flow may be calculated with the use of a hydraulic characteristic pumping diagram of the pump. Thus, the volume flow delivered by the pump is obtained from a very simple measurement, with the sensors requiring verylittle space.
Instead of two pressure sensors, a single differential pL~Ule sensor may be provided that measures the di~lcll~ial pressure between the delivery side and the intake side of the pump. Such a differential pressure sensor does not provide an absolute pressure val-ue, but rather yields a value of the differential pressure which is the essential value for cletetrnining the volume flow. On the other hand, such a diLL'~;lelllial pressure sensor may at the same time be used for locating the pump within the heart.
The pressure measuring means need not~have one or more pressure sensors. Rather, the pressure may also be determined indirectly via a current measuring means that mea-CA 022~6427 1998-11-26 sures the motor current and calculates the differential pres~ between the delivery side and the intake side of the pump from the motor current and the rotational speed.
The present invention further relates to an intracardiac blood pump offering thepossibility to monitor the positioning of the pump in the heart without requiring any x-ray control for that purpose. A blood pump of this type is defined in claim 6. A measur-ing means provides an information signal corresponding to the differential pressure between the delivery side and the intake side of the pump. On a display device, either the information signal or a signal derived therefrom or information on the correct positioning of the pump in the heart are displayed. Here, use is made of the fact that a differential pressure between two different locations of the pump-can occur only, if between these two locations, there is an element enclosing the pump, e.g. a cardiac valve. As long as there is no differential pressure between these two locations, the pump as a whole is in the same space. A dirr~ lial pressure will appear only when a part of the pump is in another space. Due to this fact, the position of he pump may be determined by simple means.
Preferably, the pump is designed as an intravascular pump as described in W097/376-96 (published posteriorly). Such an intravascular blood pump is connected to a catheter.
It is small enough to be pushed through a blood vessel to the place where it is int~-ntled to work, or it may also be operated in the blood vessel. In an intravascular blood pump of this type, the pump portion and the drive portion have substantially the same diame-ter of no more than about 5 - 7 mm, since the vessel width in peripheral regions of the body is slightly larger than 7 mm at most. The rigid length of such a pump must not be greater than about 35 mm so that the pump can manage to pass through bends of blood vessels. However, the pump may fu~ther be prolonged by means of a flexible hose that increases the effective length of the pump.
On the other hand, it is possible to surgi~ally introduce the pump into the heart via the vessel system near the heart. In any case, the pump is small enough to fit into the heart, CA 022~6427 1998-11-26 including the vestibules and the adjacent vascular stumps, and to be operated in the heart without parts of the pump e~ten(1in~ from the heart. If any, the catheter connected to the pump is lead out from the heart. This catheter not only includes the lines for supplying electric energy to the pump, but also the signal lines leading from the sensors of the pump to the extracorporeal conkol unit.
The following is a detailed description of embotliments of the present invention taken in conjunction with the acco~ llyillg.drawings.
In the Figures:
Fig. 1 illustrates a ~ehem~tic l~ngitll~lin~l section of one embodiment of an intracardiac blood pump, Fig. 2 shows an embodiment of the intracardiac implement~tion of two intravascular pumps, Fig. 3 is a s~hems~tic diagram for explaining a pump system, Fig. 4 is a diagram for showing the dependance of the volume flow on the differential pressure between the intake side and the delivery side of a pump, Fig. S shows a diagrarn of the variation in time of di~el~ell~ pressures in the heart, Fig. 6 illustrates a longitll~1in~1 section of a part of the blood pump comprising a differential pressure sensor, and Fig. 7 is a ~ m for showing the dependance of the volume flow on the motor current and the rotational speed. ~
CA 022~6427 1998-11-26 Fig. 1 shows an intravascular blood pump 10, i.e. a blood pump that may be pushed through the blood vessel system of a patient to eventually arrive in the heart. The outer diameter of such a pump is nowhere larger than 7 mm.
The pump 10 comprises a drive portion 11 and a rigidly connected pump portion 12.
The drive portion 11 has an elongated cylindrical housing 20 accommodating an electric motor 21. At the rear end, the housing 20 is closed with an end wall 22 which is followed by a flexible catheter 14 sealing the same. The electric lines 23 for power supply and for controlling the electric motor 21 and further lines 23a connected to the sensors of the pump 10 extend through this catheter 14.
As is typical, the stator 24 of the motor has a plurality of circumferentially distributed coils and a magnetic yoke arranged in the longitudinal direction. It is firmly connected to the motor housing 20. The stator 24 surrounds the rotor 26 that is connected with the motor shaft 25 and is made of perm~nent magnets magnetized in the effective/active direction. A bearing 27 supports the rear end of the motor shaft in the motor housing or the end wall 22. The motor shaft extends throughout the entire length of the motor housing 20 and projects therefrom to the front.
The front closure of the motor housing is formed by a tubular stationary hub member 30 having its rear end located in a reduced diameter projection 20a of the housing 20.
The outer diameter of the hub member tapers towards the front end where a bearing 33 for supporting the motor shaft 25 is situated. This bearing is ~imlllt~neously designed as a shaft seal.
The motor shaft 25 protrudes forward from the hub member 30, where it carries animpeller wheel 34 with a hub 35 sitting on the shaft end and blades 36 or pump vanes protruding therefrom and being oblique with respect to the axis of the impeller wheel 34. The impeller wheel 34 is accommQdated in a cylindrical pump housing 32 con-nected with the motor housing 20 by three circumferentially distributed webs 38. The ~ CA 022~6427 1998-11-26 .
motor housing 20 and the pump housing 32 are rigidly interconnected by means of a ring 38 and have equal outer diameters. The dialneter ofthe purnp 10 is nowhere larger than this outer diameter.
When the impeller wheel 34 rotates, blood is drawn through the intake opening 37 of the pump housing 32 and forced rearward in the axial direction in the pump housing 32.
Through the annular gap between the pump housing 32 and the motor housing 20, blood flows outward along the hub member 30 to further flow along the motor housing 20. Thereby, the heat generated in the drive is carried away without the blood being damaged by excessively high surface tempc~dtul~s (above 41~ C) on the motor housing 20.
It is also possible to design the pump portion 12 for the opposite delivery direction, the blood being drawn along the motor housing and being discharged axially at the front end opening 27.
Fig. 2 illustrates an embodiment wherein two generally identical pumps lOa, lOb,configured as illustrated in Fig. 1, are used in a heart to support the heart or as a substi-tute for the pumping function of the heart when the heart is immobilized. Both pumps lOa, lOb are connected with a catheter 14a, 14b, respectively. They have been placed percutaneously, the catheter 14a of the left cardiac pump lOa e~rt~ntling through the aorta 40 and a hose 13 prolongating the pump lOa being advanced into the left ventricle 42 through the aortic valve 41. Here, the pump portion 12 is prolongated by the flexible hose 13 connected with the pump housing 32, the end and/or the side wall of the hose being provided with openings for blood to enter into the pump lOa. The pump lOa takes in through the hose 13 and delivers blood into the aorta 40, while the aortic valve 41 abuts on the pump housing 32 or the hose 13 from outside. Thus, in the left ventricle 42, the pump 1 Oa is operated as a left heart pump with axial intake.
, CA 022~6427 1998-11-26 The other pump 1 Ob is operated as a right heart pump in fluid conllllullication with the right ventricle 43. The catheter 14b passes through the upper or the lower vena cava 44 into the right atrium 45. The hose 13 of the pump lOb projects through the tricuspidal valve 43a and the pulmonary valve 46 into the pulmonary artery 47 from where theblood flows to the lung 48 for oxygenizing. The oxygenized blood the flows into the left vestibule 49 and on into the left ventricle 42.
The pump 1 Ob takes in through the radial inlet 50 and conveys blood through the hose 13 axially into the plllm~n~ry artery 47. Thus, the pump 10b is operated inversely to the pump lOa.
Both pumps lOa, lOb are introduced into the heart without one of the ventricles having to be surgically opened.
Fig. 3 is a schematic illustration of the two pumps lOa, lOb with different sensors.
Specifically, the outer surface of the drive unit 11 is provided with a first pressure sensor 60 located close to the radial opening 51, whereas a second pressure sensor 61 is arranged near the inlet of the pump housing. The lines 23a of the sensors are inte-grated into the elemen1~.~ of the pump and extend through the catheter 14 together with the supply lines 23. The sensor surface of the pressure sensor 60 is on the exterior of the motor housing. Conversely, the sensor face of the pl~;S~ sensor 61 is provided on the inner surface of the hose 13. Further, a temperature sensor may be provided at the drive portion for monitoring the motor temperature.
Similarly, in the pump lOb, a first pressure sensor 62 is provided on the outer surface of the motor housing and a further pressure sensor 63 is provided on the inner surface of the hose 13. The lines of these sensors also extend through the catheter 14. The catheter 14 is provided with an oxygen sensor 64 providing information on the oxygen-ation of the blood.
CA 022~6427 1998-11-26 The supply lines 23 and the lines 23a are connected with an extracorporeal interface 65,. This int~rf~ce supplies the signals from the sensors to a control unit 66 that evalu-ates these signals and controls the pumps la, 10b in dependence thereon. A keypad and display device 67 is connected with the control unit 66 to allow for information to be entered and displayed.
Using the information supplied by the sensors, it is possible to determine the position of a pump relative to an external enclosing member, e.g. a cardiac valve. When the pump inlet and the pump outlet are on different sides of the enclosing member, adifferential pressure will appear at the pressure sensors due to the different pressure conditions. When the heart beats, this differential pressure also varies in time. On the other hand, equal measured pressure values indicate an incorrect positioning of the pump because both pleS~ sensors measure the same pl~s~ule. The evaluation of the data supplied by the two plt;~ule sensors, with consideration to the motor current, provides important information on the positioning and the operation of the pump. By comparing the differential pressure to the momentaneous motor current, it is also possible to clet~rrnine blocking conditions or cavitation.
Information on the inlet and outlet pl1S~ ;;S of the pump, together with the energy consumption of the electric motor, provide important statements on the functioning of a pump device. They also supply a real time indication on the volume flow and allow for the pump to be positioned without x-ray or ultrasonic control. Moreover, a real time monitoring of an impeded inlet flow can be effected, as may be caused, e.g., by a collapse of the ventricle, thrombogenesis, occlusion of the hose or by cardiac tissue being drawn in. Further, the sensors make it possible to monitor the wearing of bear-ings, of failures of the motor or to predict such events. Furthermore, the operation of the pump can be m~int~ined with acceptable total hemolysis rates for the required period of use and with the required volume flow of 3.6 to 5 l/min. The performance trends of various parameters may be~displayed and analyzed for several hours of operation, with alarm conditions that require immediate intervention being detected CA 022~6427 1998-11-26 without nece~it~tin~ perm:~nent control by personnel. Further, the heart of a patient can be monitored without removing the pump. When placing two instrumented pumps, to supply the control unit with the local information provided by one pump so as tocontrol the operation of the other pump, thereby optimi7ing the performance of the overall system.
The control unit 66 controls both pumps lOa, lOb such that each pump delivers a certain volume flow (volume of blood per unit time). In doing so, the right heart pump lOb pumps a predetermined percentage of the volume flow of the left heart pump lOa, for example 90%. The volume flow of the right heart pump is always smaller than that of the left heart pump. Primarily, the pumping capacity of the left heart pump lOa is controlled such that a predetermined volume flow is m~int~ined. Subsequently, the g capacity ofthe right heart pump lOb is d~ "~ ed as a function thereof. This is a master-slave operation, where usually the left heart pump lOa is the master and the right heart pump 1 Ob is the slave.
The pumps are driven by synchronous motors, with the control unit 66 supplying the required drive frequency or rotational speed n. The volume flow of each pump is a function of the rotational speed n.
Fig. 4 illustrates the volume flow V of a pump in dependance on the dirre;iellLial ples:~u~ P between the intake side and the delivery side of the pump for respective different rotational speeds n. Each parallel straight line relates to a specific rotational speed n. It is evident that the volume flow V may be calculated from the differential pressure l~P when the rotational speed n is known. The motor 21 is an electronically col ""I~ d synchronous motor. Since the rotational speed is preset by the control unit, the rotational speed is known. The differential pressure ~P is det~rmined by means of the sensors 60 and 61 or 62 and 63, respectively. Moreover, of course, the absolute values of the pressures are measured an~d evaluated as well.
CA 022~6427 1998-11-26 When a pump takes in through the radial intake opening 50 or 51 and delivers into the hose 13, the pressure at the hose-side pressure sensor 61 or 63 is greater than at the intake-side pressure sensor 60 or 62. However, when the pump pumps in the opposite direction, i.e. when it takes in through the hose 13, the pressure at the pressure sensor 60 or 62 is greater than the pressure at the pressure sensor 61 or 63, respectively.
It can happen that one of the pumps is entirely or partly occluded by the pump getting sucked to cardiac tissue or the valve a~aL~ ,. In this case, the pressure sensors supply abnormal values. The rotational speed of the respective pump will then be reduced for a ceratin time so that the cardiac tissue may disengage itself, and, subsequently, the rotational speed will be increased again to the desired number. When the measured absolute ple'7~ becomes too high, the control unit 66 will effect a limitation - and, if need be, a reduction - of the volume flow to avoid damage to downstream organs (lungs).
Measuring the pressure also provides a watch function. The pressure in the rightventricle or in the pulmonary artery must not exceed a certain value, and the pressure in the left ventricle or in the aorta must not fall below a certain pLeS~iule~ When corre-sponding pressure deviations are (1etecte~l an alarm is emitted or an adjustment is effected.
Fig. 5 illustrates the pl~s~ult; variation pl in the left ventricle of the beating heart with the systoles S and the diastoles D. One can see a strongly p~ ting pressure that drops sharply between systoles S. Moreover, the pressure variation p2 in the aorta is illus-trated. The aortic pressure may also pulsate, yet it does so in a much narrower pressure range. The dirreLc;lllial pressure ~P is ~leterrnined from p2 - pl. This differential pressure may be determined with the pressure sensors provided on the pumps.
Mc~lrin~ the pressures and the differe~tial pressures is important in particular for the insertion of the pump into the correct position in the heart. The insertion may be done CA 022~6427 1998-11-26 with the pump at a standstill or running at a low rotational speed while the heart is beating. When one pressure sensor detects the strongly pulsating pressure variation p 1 and the other detects the weakly pulsating pl~S~ variation p2, the purnp is positioned correctly.
However, measuring the pressure is not necessary for positioning. Rather, the position-ing may also be monitored by means of the current variation of the pump. As long as the inlet and the outlet of a pump are in the same space, both are subjected to the same X~Ule. If the pump is driven with a certain rotational speed, the variation in time of the pump current is constant. If, however, the outlet and the inlet of the pump are in different spaces with pressures varying in time, no smooth, but a p~ ting pump current will be obtained. Thus, it can be determined on the basis of the pump current, whether the cardiac valve correctly encloses the pump housing or the hose so that the inlet of the pump is located in the ventricle or the vestibule and the outlet is in the aorta or the pulmonary artery.
The sensors 61, 62 described above are absolute plc;s~ul~ sensors. Fig. 6 illustrates an embodiment compri~inp~ a differential pressure sensor 70 arranged in an opening 71 in the wall of the pump housing 32. The differential pressure sensor 70 has a flexible membrane 72 carrying electric resi~t~nce elements (not illustrated), the resistance of which depends on the deform~-ti- n of the membrane 72. When the pump takes in via the opening 37, the inlet pressure of the pump acts on the lower surface of the mem-brane 72. The outlet pressure of the pump acts on the outer surface of the membrane 72.
It is assumed that a cardiac valve 73 abuts against the outside of the hose 13. When the hose 13 is passed through the cardiac valve 73, a differential ~les~ult; occurs at the di~lelllial pressure sensor 70. If, however, the entire pump is in the same chamber, no substantial di~el~lllial pressure occurs at the pres~ sensor. By evaluating the signal from the differential pressure sensor 70, one may thus determine, whether the blood pump is in the correct position. .
CA 022~6427 1998-ll-26 However, determinin~ the position of the blood pump in the heart does not require a pressure measuring device at all. All that is needed is a measuring device that supplies an information signal corresponding to the dirr~;lelllial pressure between the outlet side and the inlet side of the pump. This me~nring device may be a device measuring the motor current of the motor driving the pump. The diagram of Fig. 7, similar to that of Fig. 4, illustrates the volume flow V of a pump as a function of the current I of the motor driving this pump for dirr~l~lll rotational speeds n, respectively. Each of the parallel straight lines relates to a certain rotational speed n. It is evident that the volume flow V may be tlet~rmined from the amount of the current I, when the rotational speed n is known. Thus, the volume flow V may be cleterrnined by simply measuring the current. Moreover, the correct position of the pump in the heart can also be verified by measuring the current.
When the heart is beating and the blood pump is positioned as the blood pump 10a shb-wn in Fig. 2, the pulsating pressure cleci n~tetl Pl in Fig. 5 is caused in the ventricle 42 at the inlet of the blood pump. On the other hand, the less pl~ tin~ pressure P2 of Fig.
S is generated at the pump outlet. In this case, the differential pressure ~\P is a pnl~sltinp value. If, on the other hand, the blood pump is entirely located in the aorta, the pressure difference between the inlet and the outlet of the pump is substantially zero. The same is true when the blood pump is entirely located in the left ventricle 42. Thus, by mea-suring the plll~tinp~ dirrelel,lial pressure l\P (Fig. S), the correct position of the pump may be determined.
Comparing the diagrams of Figs. 4 and 7, it is evident that, for constant rotational speeds, the current I consumed by the motor is proportional to the differential pressure l\P. If a plll.~tinp dirrel~;nlial pressure ~P is obtained, the motor current I is also plll~tin~ Thus, the pulsation of the motor current I helps in determinin~, when the correct pump position is reached. In this case, the variation of the current I may be used as an information signal. .
The invention allows to control the pump operation so as to obtain a desired volume flow as a function of the result of a pressure measurement or the result of a current measurement. These measurements may be taken in a very simple manner without voluminous measuring devices so that the operation of the pump may be accuratelymonitored, despite the compact structure.
Claims (10)
1. An intracardiac blood pump comprising a drive portion (11) with a motor (21), and a pump portion (12) rigidly connected with the drive portion, the drive portion and the pump portion having substantially the same diameter and being arranged coaxially with a mutual axial distance, and comprising a pressure measuring device (60, 61; 70), characterized in that the pressure measuring device (60, 61, 70) is arranged such that it is influenced by the pressure at the outlet side of the pump, and that a control unit (66) controls the motor (21) as a function of the signal from the pressure measuring device.
2. The blood pump of claim 1, characterized in that the pressure measuring device (60, 61) comprises a first pressure sensor (60) measuring the pressure at the outlet side of the pump, and a second pressure sensor (61) measuring the pressure at the inlet side of the pump, and that the control unit (66) controls the rotational speed of the motor (21) as a function of the signals from both pressure sensors (60, 61).
3. The blood pump of claim 2, characterized in that means are provided that calculate the differential pressure between the outlet side and the inlet side of the pump from the signals of both pressure sensors (60, 61) and controls the rotational speed of the motor (21) in dependance thereon.
4. The blood pump of one of claims 1 - 3, characterized in that the pressure measuring device comprises a differential pressure sensor (70) measuring the differential pressure between the outlet side and the inlet side of the pump.
5. The blood pump of one of claims 1-4, characterized in that the pressure measuring device comprises a current measuring device for measuring the motor current (I) and for determining the differential pressure between the outlet side and the inlet side of the motor form the motor current (I) and the rotational speed (n).
6. An intracardiac blood pump comprising a drive portion (11) with a motor (21), and a pump portion (12) rigidly connected with the drive portion, the drive portion and the pump portion having substantially the same diameter and being arranged coaxially with a mutual axial distance, and comprising a measuring device, characterized in that the measuring device supplies an information signal corresponding to the differential pressure between the outlet side and the inlet side of the pump, and that a display device is provided that, depending on the variation in time of the information signal, supplies information on the correct positioning of the pump in the heart.
7. An intracardiac blood pump comprising a drive portion (11) with a motor (21), and a pump portion (12) rigidly connected with the drive portion, the drive portion and the pump portion having substantially the same diameter and being arranged coaxially with a mutual axial distance, and comprising a measuring device, characterized in that the measuring device supplies an information signal corresponding to the differential pressure between the outlet side and the inlet side of the pump, and that a control unit (66) controls the rotational speed of the motor (21) as a function of the information signal.
8. The blood pump of claim 6 or 7, characterized in that the information signal is derived from the differential pressure given by two pressure sensors (60, 61) or from he signal from one differential pressure sensor (70).
9. The blood pump of claim 6 or 7, characterized in that the information signal is derived from the motor current (I).
10. The blood pump of one of claims 1 - 9, characterized in that the drive portion (11) is provided with a temperature sensor that triggers an alarm upon reaching a predetermined temperature.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/832,040 US5911685A (en) | 1996-04-03 | 1997-04-02 | Method and apparatus for cardiac blood flow assistance |
US08/832,040 | 1997-04-02 | ||
PCT/EP1998/001866 WO1998043688A1 (en) | 1997-04-02 | 1998-03-31 | Intracardiac blood pump |
Publications (1)
Publication Number | Publication Date |
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CA2256427A1 true CA2256427A1 (en) | 1998-10-08 |
Family
ID=25260507
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002256423A Abandoned CA2256423A1 (en) | 1997-04-02 | 1998-03-31 | Method for producing a micromotor |
CA002256432A Abandoned CA2256432A1 (en) | 1997-04-02 | 1998-03-31 | Intracardiac pump device |
CA002256427A Abandoned CA2256427A1 (en) | 1997-04-02 | 1998-03-31 | Intracardiac blood pump |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002256423A Abandoned CA2256423A1 (en) | 1997-04-02 | 1998-03-31 | Method for producing a micromotor |
CA002256432A Abandoned CA2256432A1 (en) | 1997-04-02 | 1998-03-31 | Intracardiac pump device |
Country Status (11)
Country | Link |
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US (3) | US5964694A (en) |
EP (3) | EP0904630B1 (en) |
JP (3) | JP4179634B2 (en) |
CN (1) | CN1222863A (en) |
AT (2) | ATE255430T1 (en) |
AU (3) | AU7428098A (en) |
BR (2) | BR9804804A (en) |
CA (3) | CA2256423A1 (en) |
DE (3) | DE59810906D1 (en) |
IL (1) | IL127248A0 (en) |
WO (3) | WO1998044619A1 (en) |
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- 1998-03-31 BR BR9804804A patent/BR9804804A/en unknown
- 1998-03-31 DE DE59810330T patent/DE59810330D1/en not_active Expired - Lifetime
- 1998-03-31 WO PCT/EP1998/001867 patent/WO1998044619A1/en active IP Right Grant
- 1998-03-31 CA CA002256423A patent/CA2256423A1/en not_active Abandoned
- 1998-03-31 WO PCT/EP1998/001866 patent/WO1998043688A1/en active IP Right Grant
- 1998-03-31 CA CA002256432A patent/CA2256432A1/en not_active Abandoned
- 1998-03-31 JP JP54115698A patent/JP4179634B2/en not_active Expired - Lifetime
- 1998-03-31 EP EP98919196A patent/EP0904630B1/en not_active Expired - Lifetime
- 1998-03-31 AT AT98921408T patent/ATE255430T1/en not_active IP Right Cessation
- 1998-03-31 IL IL12724898A patent/IL127248A0/en unknown
- 1998-03-31 CN CN98800423A patent/CN1222863A/en active Pending
- 1998-03-31 US US09/194,725 patent/US6139487A/en not_active Expired - Lifetime
- 1998-03-31 AT AT98919196T patent/ATE400917T1/en not_active IP Right Cessation
- 1998-03-31 EP EP98921408A patent/EP0925081B1/en not_active Expired - Lifetime
- 1998-03-31 CA CA002256427A patent/CA2256427A1/en not_active Abandoned
- 1998-03-31 AU AU74280/98A patent/AU7428098A/en not_active Abandoned
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- 1998-03-31 US US09/194,644 patent/US6058593A/en not_active Expired - Lifetime
- 1998-03-31 WO PCT/EP1998/001868 patent/WO1998043689A1/en active IP Right Grant
- 1998-03-31 EP EP98921407A patent/EP0925080B1/en not_active Expired - Lifetime
- 1998-03-31 JP JP54115798A patent/JP3982840B2/en not_active Expired - Lifetime
- 1998-03-31 DE DE59814250T patent/DE59814250D1/en not_active Expired - Lifetime
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Also Published As
Publication number | Publication date |
---|---|
DE59814250D1 (en) | 2008-08-21 |
EP0925080A1 (en) | 1999-06-30 |
EP0925081A1 (en) | 1999-06-30 |
US5964694A (en) | 1999-10-12 |
EP0904630A1 (en) | 1999-03-31 |
DE59810330D1 (en) | 2004-01-15 |
CN1222863A (en) | 1999-07-14 |
ATE400917T1 (en) | 2008-07-15 |
IL127248A0 (en) | 1999-09-22 |
JP2000512191A (en) | 2000-09-19 |
JP4179634B2 (en) | 2008-11-12 |
AU7213298A (en) | 1998-10-22 |
WO1998043689A1 (en) | 1998-10-08 |
JP2000511455A (en) | 2000-09-05 |
WO1998044619A1 (en) | 1998-10-08 |
BR9804832A (en) | 1999-08-24 |
US6139487A (en) | 2000-10-31 |
CA2256432A1 (en) | 1998-10-08 |
EP0904630B1 (en) | 2008-07-09 |
AU7427998A (en) | 1998-10-22 |
DE59810906D1 (en) | 2004-04-08 |
JP4179635B2 (en) | 2008-11-12 |
BR9804804A (en) | 1999-08-17 |
ATE255430T1 (en) | 2003-12-15 |
JP2000511759A (en) | 2000-09-05 |
US6058593A (en) | 2000-05-09 |
WO1998043688A1 (en) | 1998-10-08 |
EP0925081B1 (en) | 2003-12-03 |
CA2256423A1 (en) | 1998-10-08 |
EP0925080B1 (en) | 2004-03-03 |
JP3982840B2 (en) | 2007-09-26 |
AU7428098A (en) | 1998-10-22 |
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Legal Events
Date | Code | Title | Description |
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FZDE | Discontinued |