CA2253850A1 - Method and apparatus for automatically detecting malignancy-associated changes - Google Patents

Method and apparatus for automatically detecting malignancy-associated changes

Info

Publication number
CA2253850A1
CA2253850A1 CA002253850A CA2253850A CA2253850A1 CA 2253850 A1 CA2253850 A1 CA 2253850A1 CA 002253850 A CA002253850 A CA 002253850A CA 2253850 A CA2253850 A CA 2253850A CA 2253850 A1 CA2253850 A1 CA 2253850A1
Authority
CA
Canada
Prior art keywords
associated changes
sample
malignancy
intensity
automatically detecting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002253850A
Other languages
French (fr)
Other versions
CA2253850C (en
Inventor
Calum Eric Macaulay
Branko Palcic
David Michael Garner
S. Alan Harrison
Bruno W. Jaggi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MonoGen Inc
Original Assignee
Oncometrics Imaging Corp.
Calum Eric Macaulay
Branko Palcic
David Michael Garner
S. Alan Harrison
Bruno W. Jaggi
Monogen, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncometrics Imaging Corp., Calum Eric Macaulay, Branko Palcic, David Michael Garner, S. Alan Harrison, Bruno W. Jaggi, Monogen, Inc. filed Critical Oncometrics Imaging Corp.
Priority to CA002595118A priority Critical patent/CA2595118A1/en
Publication of CA2253850A1 publication Critical patent/CA2253850A1/en
Application granted granted Critical
Publication of CA2253850C publication Critical patent/CA2253850C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • G01N33/5017—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity for testing neoplastic activity
    • G01N15/1433—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts

Abstract

A method for detecting malignancy-associated changes. A sample of cells is obtained and stained to identify the nuclear DNA
material. The sample is imaged with a digital microscope. Objects of interest are identified in the sample of cells based on the intensity of the pixels that comprise the object versus the average intensity of all pixels in the slide image. An exact edge is located for each object and variations in the illumination intensity of the microscope are compensated for. A computer system calculates feature values for each object and, based on the value of the features, a determination is made whether the cell exhibits malignancy-associated changes or not.
CA002253850A 1996-05-10 1997-05-01 Method and apparatus for automatically detecting malignancy-associated changes Expired - Fee Related CA2253850C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002595118A CA2595118A1 (en) 1996-05-10 1997-05-01 Method and apparatus for automatically detecting malignancy-associated changes

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/644,893 US5889881A (en) 1992-10-14 1996-05-10 Method and apparatus for automatically detecting malignancy-associated changes
US08/644,893 1996-05-10
PCT/CA1997/000301 WO1997043732A1 (en) 1996-05-10 1997-05-01 Method and apparatus for automatically detecting malignancy-associated changes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002595118A Division CA2595118A1 (en) 1996-05-10 1997-05-01 Method and apparatus for automatically detecting malignancy-associated changes

Publications (2)

Publication Number Publication Date
CA2253850A1 true CA2253850A1 (en) 1997-11-20
CA2253850C CA2253850C (en) 2007-09-18

Family

ID=24586780

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002253850A Expired - Fee Related CA2253850C (en) 1996-05-10 1997-05-01 Method and apparatus for automatically detecting malignancy-associated changes

Country Status (6)

Country Link
US (2) US5889881A (en)
EP (1) EP0901665A1 (en)
JP (1) JP2000510266A (en)
AU (1) AU2377997A (en)
CA (1) CA2253850C (en)
WO (1) WO1997043732A1 (en)

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Also Published As

Publication number Publication date
CA2253850C (en) 2007-09-18
JP2000510266A (en) 2000-08-08
US6493460B1 (en) 2002-12-10
WO1997043732A1 (en) 1997-11-20
EP0901665A1 (en) 1999-03-17
US5889881A (en) 1999-03-30
AU2377997A (en) 1997-12-05

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