CA2252431A1 - Method of magnetic resonance imaging and spectroscopic analysis and associated apparatus - Google Patents

Method of magnetic resonance imaging and spectroscopic analysis and associated apparatus

Info

Publication number
CA2252431A1
CA2252431A1 CA002252431A CA2252431A CA2252431A1 CA 2252431 A1 CA2252431 A1 CA 2252431A1 CA 002252431 A CA002252431 A CA 002252431A CA 2252431 A CA2252431 A CA 2252431A CA 2252431 A1 CA2252431 A1 CA 2252431A1
Authority
CA
Canada
Prior art keywords
magnetic resonance
antenna
specimen
processor
loopless
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002252431A
Other languages
French (fr)
Other versions
CA2252431C (en
Inventor
Ogan Ocali
Ergin Atalar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Original Assignee
The Johns Hopkins University
Ogan Ocali
Ergin Atalar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Johns Hopkins University, Ogan Ocali, Ergin Atalar filed Critical The Johns Hopkins University
Priority to CA002648973A priority Critical patent/CA2648973C/en
Publication of CA2252431A1 publication Critical patent/CA2252431A1/en
Application granted granted Critical
Publication of CA2252431C publication Critical patent/CA2252431C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/32—Excitation or detection systems, e.g. using radio frequency signals
    • G01R33/34—Constructional details, e.g. resonators, specially adapted to MR
    • G01R33/34084—Constructional details, e.g. resonators, specially adapted to MR implantable coils or coils being geometrically adaptable to the sample, e.g. flexible coils or coils comprising mutually movable parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0233—Pointed or sharp biopsy instruments
    • A61B10/0266—Pointed or sharp biopsy instruments means for severing sample
    • A61B10/0275—Pointed or sharp biopsy instruments means for severing sample with sample notch, e.g. on the side of inner stylet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A61B2090/374—NMR or MRI

Abstract

The invention provides a method for magnetic resonance imaging and spectroscopic analysis of a specimen which includes positioning the specimen within a main magnetic field and introducing an antenna having a loopless antenna portion in close proximity to the specimen.
Radio frequency pulses are provided to the region of interest to excite magnetic resonance signals, gradient magnetic pulses are applied to the region of interest with the antenna receiving magnetic resonance signals and emitting responsive output signals. A processor processes the responsive output signals to provide image information for display in a desired manner. The method in a preferred form involves employing a flexible antenna. The method in another preferred form involves employing an impedance matching circuit electrically interposed between the loopless antenna and the processor to enhance radio frequency power transfer and magnetic resonance signal-to-noise ratio from the loopless antenna to the processor. The method may be used on a wide variety of specimens and in a preferred use is introduced into small blood vessels of a patient to facilitate determination of atherosclerotic plaque. Medical intervention procedures, such as plaque removal, may be employed generally simultaneously with the imaging of the present invention. Corresponding apparatus and magnetic resonance antenna assembly are provided.
CA002252431A 1996-04-25 1997-04-18 Method of magnetic resonance imaging and spectroscopic analysis and associated apparatus Expired - Lifetime CA2252431C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002648973A CA2648973C (en) 1996-04-25 1997-04-18 Method of magnetic resonance imaging and spectroscopic analysis and associated apparatus

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/638,934 US5928145A (en) 1996-04-25 1996-04-25 Method of magnetic resonance imaging and spectroscopic analysis and associated apparatus employing a loopless antenna
US08/638,934 1996-04-25
PCT/US1997/006444 WO1997040396A1 (en) 1996-04-25 1997-04-18 Method of magnetic resonance imaging and spectroscopic analysis and associated apparatus

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002648973A Division CA2648973C (en) 1996-04-25 1997-04-18 Method of magnetic resonance imaging and spectroscopic analysis and associated apparatus

Publications (2)

Publication Number Publication Date
CA2252431A1 true CA2252431A1 (en) 1997-10-30
CA2252431C CA2252431C (en) 2009-07-28

Family

ID=24562048

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002648973A Expired - Lifetime CA2648973C (en) 1996-04-25 1997-04-18 Method of magnetic resonance imaging and spectroscopic analysis and associated apparatus
CA002252431A Expired - Lifetime CA2252431C (en) 1996-04-25 1997-04-18 Method of magnetic resonance imaging and spectroscopic analysis and associated apparatus

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA002648973A Expired - Lifetime CA2648973C (en) 1996-04-25 1997-04-18 Method of magnetic resonance imaging and spectroscopic analysis and associated apparatus

Country Status (8)

Country Link
US (1) US5928145A (en)
EP (1) EP0898716B1 (en)
JP (1) JP2000509296A (en)
AT (1) ATE337558T1 (en)
AU (1) AU729864B2 (en)
CA (2) CA2648973C (en)
DE (1) DE69736550T2 (en)
WO (1) WO1997040396A1 (en)

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