CA2224060A1 - Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide - Google Patents

Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide

Info

Publication number
CA2224060A1
CA2224060A1 CA002224060A CA2224060A CA2224060A1 CA 2224060 A1 CA2224060 A1 CA 2224060A1 CA 002224060 A CA002224060 A CA 002224060A CA 2224060 A CA2224060 A CA 2224060A CA 2224060 A1 CA2224060 A1 CA 2224060A1
Authority
CA
Canada
Prior art keywords
catalysts
manganese
nitrogen
iron complexes
macrocyclic ligands
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002224060A
Other languages
French (fr)
Other versions
CA2224060C (en
Inventor
William L. Neumann
Dennis P. Riley
Randy H. Weiss
Susan L. Henke
Patrick J. Lennon
Karl W. Aston
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2224060A1 publication Critical patent/CA2224060A1/en
Application granted granted Critical
Publication of CA2224060C publication Critical patent/CA2224060C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic System
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
    • C07F15/02—Iron compounds
    • C07F15/025—Iron compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915—Therapeutic or pharmaceutical composition

Abstract

Low molecular weight mimics of superox-ide dismutase (SOD) represented by formula (I), wherein R, R', R1, R'1, R2, R'2, R3, R'3, R4, R'4, R5, R'5, R6, R'6, R7, R'7, R8, R'8, R9, and R'9, M, X, Y, Z and n are as defined herein, use-ful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, stroke, atherosclerosis, and all other conditions of oxidant-induced tissue damage or injury.
CA002224060A 1995-06-06 1996-05-31 Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide Expired - Lifetime CA2224060C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US46885495A 1995-06-06 1995-06-06
US08/596,887 1996-03-14
US08/468,854 1996-03-14
US08/596,887 US6525041B1 (en) 1995-06-06 1996-03-14 Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
PCT/US1996/007552 WO1996039396A1 (en) 1995-06-06 1996-05-31 Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide

Publications (2)

Publication Number Publication Date
CA2224060A1 true CA2224060A1 (en) 1996-12-12
CA2224060C CA2224060C (en) 2009-03-24

Family

ID=27042573

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002224060A Expired - Lifetime CA2224060C (en) 1995-06-06 1996-05-31 Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide

Country Status (7)

Country Link
US (1) US6525041B1 (en)
EP (1) EP0830352A1 (en)
JP (1) JPH11506734A (en)
CN (1) CN1191530A (en)
AU (1) AU6023796A (en)
CA (1) CA2224060C (en)
WO (1) WO1996039396A1 (en)

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EP0844886A2 (en) * 1995-08-17 1998-06-03 Monsanto Company Bioconjugates of manganese complexes and their application as catalysts
WO1997006830A1 (en) * 1995-08-17 1997-02-27 Monsanto Company Methods of diagnostic image analysis using bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands
WO1997006831A1 (en) * 1995-08-17 1997-02-27 Monsanto Company Methods of diagnostic image analysis using metal complexes of nitrogen-containing macrocyclic ligands
BR9708179A (en) * 1996-03-13 1999-07-27 Monsanto Co Bioconjugates of manganese or iron complexes of nitrogen-containing macrocyclic binders effective as catalysts for demuting superoxides
KR19990087783A (en) * 1996-03-13 1999-12-27 죤 에이치. 뷰센 An iron complex of an effective nitrogen-containing macrocyclic ligand as a catalyst for disproportionation of excess oxides
US20050171198A1 (en) * 1997-06-20 2005-08-04 Metaphore Pharmaceuticals, Inc. SODm therapy for treatment, prevention, inhibition and reversal of inflammatory disease
US6214817B1 (en) 1997-06-20 2001-04-10 Monsanto Company Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity
US6180620B1 (en) * 1997-06-20 2001-01-30 G.D. Searle & Co. Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals
GB9817845D0 (en) 1998-08-17 1998-10-14 Glaxo Group Ltd Chemical compounds
EP1185312B1 (en) 1999-05-27 2005-03-23 Monsanto Company Biomaterials modified with superoxide dismutase mimics
US6264966B1 (en) * 2000-02-22 2001-07-24 Concat, Ltd. Compounds with chelation affinity and selectivity for first transition elements and their use in cosmetics and personal care products, inhibition of metalloenzymes, and inhibition of reperfusion injury
JP4369124B2 (en) * 2001-03-02 2009-11-18 メタファー・ファーマシューティカルズ・インコーポレイテッド Chromatography of metal complexes
WO2005042718A2 (en) * 2003-10-31 2005-05-12 Metaphore Pharmaceuticals, Inc. Compositions and methods for treating, preventing, reversing and inhibiting pain
US7299082B2 (en) 2003-10-31 2007-11-20 Abbott Diabetes Care, Inc. Method of calibrating an analyte-measurement device, and associated methods, devices and systems
US8165651B2 (en) * 2004-02-09 2012-04-24 Abbott Diabetes Care Inc. Analyte sensor, and associated system and method employing a catalytic agent
US7699964B2 (en) 2004-02-09 2010-04-20 Abbott Diabetes Care Inc. Membrane suitable for use in an analyte sensor, analyte sensor, and associated method
US8217166B2 (en) * 2005-05-05 2012-07-10 Galera Therapeutics, Llc Polyethylene glycolated superoxide dismutase mimetics
US20120301403A1 (en) 2007-06-21 2012-11-29 Galera Therapeutics, Llc Polyethylene glycolated superoxide dismutase mimetics
US7885698B2 (en) 2006-02-28 2011-02-08 Abbott Diabetes Care Inc. Method and system for providing continuous calibration of implantable analyte sensors
HUE044234T2 (en) 2006-10-12 2019-10-28 Galera Labs Llc Methods of treating oral mucositis
US20080161666A1 (en) * 2006-12-29 2008-07-03 Abbott Diabetes Care, Inc. Analyte devices and methods
US20090259118A1 (en) * 2008-03-31 2009-10-15 Abbott Diabetes Care Inc. Shallow Implantable Analyte Sensor with Rapid Physiological Response
US9198893B2 (en) 2008-05-22 2015-12-01 Galera Labs, Llc Combination antitumor therapy
AU2012316397B2 (en) 2011-09-26 2016-07-21 Galera Labs, Llc Methods for treatment of diseases
CN102634241B (en) * 2012-05-30 2014-01-29 沈阳化工大学 Composite modified iron oxide red dye and preparation method
CA2933166C (en) 2013-12-31 2020-10-27 Abbott Diabetes Care Inc. Self-powered analyte sensor and devices using the same
CN113402560A (en) 2015-08-11 2021-09-17 加莱拉实验室有限责任公司 Pentaazamacrocycle complexes with oral bioavailability
IL295620B2 (en) 2017-04-13 2024-01-01 Galera Labs Llc Combination cancer immunotherapy with pentaaza macrocyclic ring complex
CA3090129A1 (en) 2018-01-31 2019-08-08 Galera Labs, Llc Combination cancer therapy with pentaaza macrocyclic ring complex and platinum-based anticancer agent

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JPS5998074A (en) 1982-11-27 1984-06-06 Nippon Redarii Kk Macrocyclic dioxotetramine-copper complex
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Also Published As

Publication number Publication date
EP0830352A1 (en) 1998-03-25
US6525041B1 (en) 2003-02-25
AU6023796A (en) 1996-12-24
WO1996039396A1 (en) 1996-12-12
CA2224060C (en) 2009-03-24
CN1191530A (en) 1998-08-26
JPH11506734A (en) 1999-06-15

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Effective date: 20160531

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