CA2215752C - Fluid control device - Google Patents
Fluid control device Download PDFInfo
- Publication number
- CA2215752C CA2215752C CA 2215752 CA2215752A CA2215752C CA 2215752 C CA2215752 C CA 2215752C CA 2215752 CA2215752 CA 2215752 CA 2215752 A CA2215752 A CA 2215752A CA 2215752 C CA2215752 C CA 2215752C
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- CA
- Canada
- Prior art keywords
- flow control
- port
- adaptor
- fluid
- control device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/10—Tube connectors; Tube couplings
- A61M39/16—Tube connectors; Tube couplings having provision for disinfection or sterilisation
- A61M39/18—Methods or apparatus for making the connection under sterile conditions, i.e. sterile docking
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/22—Valves or arrangement of valves
- A61M39/223—Multiway valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2006—Piercing means
- A61J1/201—Piercing means having one piercing end
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2006—Piercing means
- A61J1/2013—Piercing means having two piercing ends
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2048—Connecting means
- A61J1/2058—Connecting means having multiple connecting ports
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2048—Connecting means
- A61J1/2058—Connecting means having multiple connecting ports
- A61J1/2062—Connecting means having multiple connecting ports with directional valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2068—Venting means
- A61J1/2075—Venting means for external venting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2079—Filtering means
- A61J1/2082—Filtering means for gas filtration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/10—Tube connectors; Tube couplings
- A61M2039/1077—Adapters, e.g. couplings adapting a connector to one or several other connectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/162—Needle sets, i.e. connections by puncture between reservoir and tube ; Connections between reservoir and tube
Abstract
A fluid control device (10) for use with a syringe and at least one medicinal vessel (28). The fluid control device includes a first port (13), a second port (12) for receiving the syringe, a third port (17) including an adaptor (20) having a fluid conduit member (24) extending into the interior of the medicinal vessel (28) when attached thereto and a flow control member (20') selectively disposable from a first flow control position enabling a flow path between a first pair of two ports (12, 17) and a second flow control position enabling a flow path between a second pair of two ports (12, 13). The flow control member (20') is coupled to one of the ports for manipulation between its flow control positions.
Description
Fluid Control Device FIELD OF THE INVENTION
The invention relates to fluid control devices in general and in particular to fluid control devices adapted for facilitating the aseptic administration of drugs to patients.
BACKGROUND OF THE INVENTION
Drugs intended for parenteral administration are typically stored in a medicinal vessel either as a dry powder or as a solution. The solution can be ready for immediate use or in the form of a liquid concentrate which requires reconstitution with a physiological solution prior to administration in a similar manner to a dry powder drug. The physiological solution can be provided in a pre-filled syringe or a medicinal vessel.
Medicinal vessels typically fall into one of three categories.
The first type is a vial or a glass bottle closed by a rubber stopper which can be penetrated by a puncturing tool, for example, a needle, and which is self-closing upon withdrawal of the puncturing tool. Such a vial or glass bottle can contain a single dose or a multiple dose of a drug. The drug contained in a vial can be under a high vacuum. The second type is an ampoule whose top portion is broken off enabling access to its contents. The third type is an IV bag provided with a sample port for enabling access to its contents. The sample port can be of the pre-slit septum type.
Regardless of the manner in which a drug is stored, there is a need to transfer fluid under sterile conditions before its administration to a patient by a dispensing tool be it a needle, a pre-slit septum, or the like. When a prior dilution of a s drug is required, the process requires at least two fluid transfers. The problem of ensuring proper fluid transfer under aseptic conditions is especially acute in the case of self-administration of drugs by patients in their homes.
Assemblies which have hitherto been proposed for the aseptic administration of drugs are described in U.S. Patent Nos: Des. 271,421, 3,618,637, lo 3,757,981, 3,826,261, 3,957,052, 3,977,555, 3,993,063, 4,051,852, 4,564,054, 4,604,093, 4,721,133, 4,758,235, 4,967,797, 4,997,430, 5,201,705, 5,269,768, 5,279,576, 5,288,290, 5,334,163, and 5,466,220, and European Publication Nos:0258913A2,0195018B1,0192661Bi,and0416454B1.
In particular, EP 0 521 460 B 1 describes a fluid control device for use 15 with a syringe and a pair of medicinal vessels. The fluid control device includes a housing with a Luer-connector port for receiving the syringe and second and third ports each comprising an adaptor having a fluid conduit member extending into the interior of a medicinal vessel when attached thereto. In the housing, a flow control member is slidingly displaceable from a first flow control position enabling a flow path between 20 the two medicinal vessels when connected and a second flow control position enabling a flow path between one of the medicinal vessels and the syringe.
- 2a -SUMMARY OF THE INVENTION
An object of some embodiments of the invention is to provide a fluid control device enabling the aseptic administration of drugs.
According to the present invention, there is provided a fluid control device for use with a syringe and at least one medicinal vessel, the fluid control device comprising: a first port, a second port for receiving the syringe, a third port comprising an adaptor having a fluid conduit member extending into the interior of the medicinal vessel when attached thereto, and a flow control member displaceable between first and second flow control positions respectively enabling flow paths between the second and third ports in the first flow control position and the second and first ports in the second flow control position, wherein the third port is coupled to the flow control member, and is rotationally displaceable between first and second control positions, whereby rotation of the third port rotates the flow control member between its first and second flow control positions.
Also according to the present invention, there is provided a fluid control device for use with a syringe and at least one medicinal vessel, the fluid control device comprising: a first port, a second port for receiving the syringe, a third port comprising an adaptor having a fluid conduit member extending into the interior of the medicinal vessel when attached thereto, and a flow control member displaceable between first and second flow control positions respectively enabling flow paths between the first and third ports in the first flow control position and the second and third ports in the second flow control position, wherein the second port is coupled to the flow control member, and is - 2b -rotationally displaceable between first and second control positions, whereby rotation of the second port rotates the flow control member between its first and second flow control positions.
According to the present invention, there is further provided a fluid control device for use with a syringe and at least one medicinal vessel, the fluid control device comprising: a first port, a second port for receiving the syringe, a third port comprising an adaptor having a fluid conduit member extending into the interior of the medicinal vessel when attached thereto, and a flow control member displaceable between first and second flow control positions respectively enabling flow paths between the first and second ports in the first flow control position and the second and third ports in the second flow control position, wherein the second port is coupled to the flow control member, and is rotationally displaceable between first and second control positions, whereby rotation of the second port rotates the flow control member between its first and second flow control positions.
According to the present invention, there is further provided a fluid control device for use with a syringe and at least one medicinal vessel, the fluid control device comprising: at least three ports including a first port; a second port for receiving the syringe; a third port comprising an adaptor having a fluid conduit member extending into the interior of the medicinal vessel when attached thereto; and a fluid control member displaceable between first and second flow control positions respectively enabling flow paths between first and second pairs of said at least three ports; wherein one of the second and third ports is coupled to the flow control member and is rotatably displaceable between first and second control positions - 2c -whereby rotation of the port correspondingly rotates the flow control member between its first and second flow control position.
_ 3 _ In accordance with some embodiments of the present invention, there is provided a family of fluid control devices which are adapted for the aseptic administration of drugs either directly or indirectly to a patient.
The selection of the most suitable fluid control device depends on the type of drug to be administered to a patient, the manner in which it is packaged, the manner in which it is to be administered to a patient and by whom apart from other factors. Some of the devices are designed to enable the reconstitution of a drug provided in a powder form or as a liquid concentrate. Some of the devices are suited for vials or ampoules containing a single dose of a drug whilst others are suited for vials or IV
bags containing multiple doses.
In some embodiments of a fluid control device, the flow control member is rotatably mounted in a body member so as to be selectively rotatable between its first flow control position and its second flow control position.
In some embodiments of a fluid control device, the first port is adapted for dispensing a drug directly or indirectly to a patient and, as such, it can be provided with a needle, it can be fashioned as a male Luer connector on which a needle can be mounted or it can be fashioned as a plastic cannula for insertion into a pre-slit septum. ' In such an embodiment, the adaptor may be coupled to a flow control member adapted for rotation in a body member having the port adapted for receiving a syringe and the dispensing port.
The adaptor can be integrally formed with the flow control member and designed so as to readily broken off therefrom after rotation of the flow control member from its first flow control position to its second flow control position. Alternatively, the adaptor can be detachably engaged to the flow control member by rneans of an interengaging means enabling axial detachment of the adaptor from the body member on a relative rotation therebetween to a position which urges the flow control member from its first flow control position to its second flow control position.
In some embodiments of a fluid control device suitable for use with drugs which require reconstitution, the fluid control device includes a fourth port in the form of an adaptor for enabling the attachment of a second medicinal vessel to the body member..
In some -embodiments of a fluid control device, the first port is also provided with an adaptor adapted for attachment thereto of a medicinal vessel and, in this case, the port adapted for receiving the syringe is rotatably coupled to the flow control member.
In each case, the adaptor can be adapted for attachment thereto of a vial, an ampoule or an IV bag, the former requiring that the fluid conduit member be formed as a puncturing tool for piercing the vial's rubber stopper on its attachment thereto. In the case of attachment of an ampoule, because the ampoule cannot be inverted, the fluid conduit member is required to be provided as a long straw to enable all or nearly all of its contents to be aspirated therefrom.
The adaptor can also include a conduit for venting the vessel when attached thereto. The conduit can include a filter for filtering the air traversing therethrough. The filter can be deployed within a lateral cavity provided within the adaptor or, alternately, the filter can be provided as a discrete element exterior to the fluid control device.
BRIEF DESCRIPTION OF THE DRAWINGS
For a better understanding of embodiments of the invention and to show how the same may be carried out in practice, and solely by way of non-limiting examples, reference will now be made to the accompanying drawings, in which:
Fig. I is a perspective view of an assembled fluid control device including a base member and an integrally formed adaptor cum flow control member for use with a syringe and a medicinal vessel;
Fig. 2 is a perspective view of the fluid control device of Figure 1 before assembly;
Fig. 3 is a vertical cross sectional view of the fluid control device of Figure 1 along the line A-A after insertion of a syringe and the attachment of a vial and before rotation of the adaptor relative to the 'base member;
Fig. 4 is a horizontal cross sectional view of the fluid control device of Figure 1 along the line B-B after insertion of a syringe and the attachment of a vial and before rotation of the adaptor relative to the base member;
Fig. 5 is a horizontal cross sectional view of the fluid control device of Figure 1 along the line C-C before rotation of the adaptor relative to the base member;
Fig. 6 is a vertical cross sectional view of the fluid control device of Figure 1 along the line A-A after rotation of the adaptor relative to the base member;
Fig. 7 is a horizontal cross sectional view of the fluid control device of Figure 1 along the line B-B after rotation of the adaptor relative to the base member;
Fig. 8 is a horizontal cross sectional view of the fluid control device of Figure 1 along the line C-C before rotation of the adaptor relative to the base member;
Fig. 9 is a perspective view of a modified integrally formed adaptor cum flow control member adapted such that the adaptor breaks off from the flow control member on rotation of the adaptor relative to the base member beyond a pre-determined position;
Fig. 10 is a perspective view of a fluid control device including the modified adaptor cum flow 'control member of Figure 9 after the adaptor has been broken off;
Fig. 11 is a perspective view of an assembled fluid control device including a base member and an adaptor designed for releasable engagement with 'the base member;
_6- -Fig. 12 is a perspective view of the fluid control device of Figure 11 after the adaptor has been rotated through a quarter turn ready for its detachment from the base member;
Fig. 13 is a vertical cross sectional view of the base member of the fluid control device of Figure 11; -Fig. 14 is a vertical cioss sectional view of the, adaptor of the fluid control device of Figure 11;
Fig. 15 is a perspective view of the flow control member of the fluid control device of Figure 11;
Figs. 16A and 16B are vertical cross sectional views of a fluid control device in which the flow control member is required to be rotated through 180 to enable switching between its flow control position;
Fig. 17 is a vertical cross sectional view of a fluid control device provided with an arrangement for the venting of a vial attached to its adaptor;
Figs. 18A and 18B are two views depicting a fluid control device having a filter for filtering air venting a vial attached to its adaptor, the filter being provided as a discrete element exterior to the device;
Fig. 19 is a vertical cross sectional view of a fluid control device having an adaptor provided with a lateral cavity for receiving a filter for filtering air venting a vial attached thereto;
Fig. 20 is a vertical cross-sectional view of a fluid control device in a first operative position enabling flow communication between a medicinal vessel containing a powder drug and a medicinal vessel containing -a physiological solution for enabling reconstitution of the powder drug;
Fig. 21 is a vertical cross sectional view of the fluid control device of Figure 20 in a second operative position enabling flow communication between the vial containing the .reconstituted drug and a syringe;
.7.-Fig. 22 is a vertical cross sectional view of the fluid control device of Figure 20 in a third operative position enabling flow communication between the syringe and a dispensing port;
'Fig. 23 is a longitudinal cross sectional view of a fluid control device for use with a syringe and a pair of.medicinal vessels;
Fig. 24 is a horizontal cross sectional view of the flow control member of the fluid control device of Figure 23 along line D-D;
Fig. 25 shows a series of steps (Figures 25A-25F) depicting the operation of the fluid control device of Figure 23;
Fig. 26 is a longitudinal cross sectional view of the fluid control device of Figure 23 with a modified flow control member;
Fig. 27 is a horizontal cross sectional view of the flow control member of Figure 26 along line E-E in Figure 26;
Fig. 28 is a longitudinal cross sectional view of a modified fluid control device of Figure 23 with an in-line filter; and Fig. 29 is a longitudinal cross sectional view of a fluid control device with a modified adaptor enabling venting of a medicinal vessel attached thereto fitted with a hydrophobic filter.
DETAILED DESCRIPTION OF THE DRAWINGS
Figures 1-8 depict a first embodiment of a fluid control device, generally designated 10, constructed and operative in accordance with the teachings of the present invention for enabling fluid flow coritrol between a syringe, a medicinal vessel and a dispensing port. The fluid control device 10 includes an elongated base member 11 having a port 12 adapted for receiving a syringe and a dispensing port 13 fashioned as a plastic cannula for insertion into a pre-slit septum assembly known in the art per se. The port 12 is typically fashioned as a female Luer connector.
As shown in Figure 3; the port 12 includes a lumen 14 having an interior opening 14' and the dispensing port 13 includes a lumen 16 having an interior opening 16'. The lumens 14 and 16 are co-axial and in flow communication via a bore 17 transversely disposed relative to the elongated base member 11. The bore 17 includes an upper peripheral flange 18 and a lower minor peripheral abutment wall portion 19' protruding radially inward relative to its major peripheral wall portion 19" (see Figure 5). As shown, the abutment wall portion 19' typically extends through an arc angle of about 90 .
The fluid control device 10 further includes -an integrally formed adaptor cum flow control member, generally designated 20, for insertion into the bore 17 in which it is restrained therein by means of a peripherally formed groove 22 designed for receiving the flange 18 therein. The flow control member 20' is formed with two flow ducts as follows: A first flow duct 23 (see Figure 3) in the form of an L-shaped channel having a radial aperture 23' for registration with the interior opening 14' and an axial aperture 23' of a fluid conduit member 24 integrally formed as part of the adaptor 20" on disposition of the flow control member 20' in a first flow control position enabling flow communication between a syringe inserted in the port 12 and a vessel attached to the adaptor 20". A second flow duct 25 (see Figure 4) in the form of a peripheral slightly longer than a semi-circular groove 25 having a first end portion 25' for registration with one of the interior openings 14' and 16' and a second end portion 25" for registration with the other of the interior openings 14' and 16' on disposition of the flow control member 20' in a second flow control position enabling flow communication between a syringe inserted in the port 12 and the dispensing port 13.
In addition, the flow control member 20' is provided with a minor peripheral abutment wall portion 26' protruding radially outward relative to its major peripheral wall portion 26" (see Figure 5). As shown, the abutment wall portion 26' typically extends through an arc angle of about 90 . The minor peripheral abutment wall portions 19' and 26' are so disposed such that they assume substantially diagonally opposing positions relative to one another (see Figure 5) in the first flow control position of the flow control member 20'.
The adaptor 20" is shown to be adapted for the attachment ti thereto of a vial 28 (not drawn to size) provided with a rubber stopper 29.
As such, the fluid conduit member 24 is fashioned as a puncturing tool 30 for penetrating a rubber stopper 29 on attachment of a vial 28 to its adaptor 20". Alternatively, the adaptor 20" can be adapted for the attachrrient thereto of an ampoule 31 (not drawn to size), the difference being that such an adaptor will preferably have relatively long springy grips.
Each stage of the two stage operation of the fluid control device 10 for the administration of a drug provided in powder form for dilution with a physiological solution provided in a pre-filled syringe is now described with reference to Figures 3-5 and Figures 6-8, respectively.
As shown in Figure 3-5, the fluid control device 10 is best provided in a set-up position in which the flow control member 20' is in its first flow control position and the two minor abutment wall portions 19' and 26' are diagonally opposed to one another. As shown, it should be noted as best seen in Figure 4, that the semi-circular groove 25 registers with the interior opening 16' but does not provide a flow path.
In this arrangement, a pre-filled syringe 32 is inserted into the port 12 and the vial 28 is attached to the adaptor 20" by means of which action, the puncturing tool 30 punctures the vial's rubber stopper 29, thereby enabling flow communication with its interior via the fluid conduit member 24. Typically, the syringe 32 requires actuation ' for expressing its contents into the vial 28 whilst, in some cases, if the contents of the vial 28 are under vacuum, then the physiological solution of the syringe 32 can be sucked into the vial without user intervention.
Thereafter, the contents of the vial 28 are shaken so as to reconstitute the powdered drug. The fluid control device 10 together with the vial 28 are then preferably inverted and the syringe 32 is aspirated so as to draw the reconstituted liquid drug thereinto.
Turning now to Figures. 6-8; the vial 28 together with the adaptor 20" are rotated in either a clockwise or a counter clockwise direction relative to the base member 11 until such time that abutment wall portion 26' is stopped by the abutment wall portion 19' (see Figure 8). On rotation of the adaptor 20", the flow control member 20' is rotated to its second flow control position enabling a flow path between the syringe 32 and the dispensing port 13 by means of the end portions 25' and 25" of the semi-circular groove 25 registering with the interior openings 14' and 16'. The drug can then be dispensed by actuation of the syringe 32.
It can now be readily appreciated that the fluid control device 10 ensures that a drug can be administered to a patient under aseptic conditions. Furthermore, it can be readily appreciated that the fluid control device 10 presents a "fool-proof' delivery device in the sense that a patient is required to perform a minimal number of actions to administer a drug and that the drug can only be dispensed in a single operative position of the fluid control device.
Figures 9 and 10 depict a second embodiment of a fluid control device, generally designated 34, constructed and operative in accordance with the teachings of the present invention for enabling fluid flow control between a syringe, a medicinal vessel and a dispensing port. The fluid control device 34 is similar in construction and operation to the fluid control device 10 and therefore the same reference numbers are used where appropriate.
The main difference between the two fluid control devices 34 and 10 resides in the fact that the former includes an integrally formed adaptor cum flow control member 35 provided with a weakened portion, generally designated 36, between its abutment wall portion 26' of its flow control member 35' and its adaptor 35". As shown, this weakened portion 36 is achieved by leaving radially extending vanes 36' formed by cut-outs 36".
The advantage of this design is that after rotation of the vial 28 (not shown) and the adaptor 35" through 90 so as to rotate the flow control member 35' from its first flow control position to its second flow control position, any further torque applied will tend to snap off the adaptor 35" which can then be discarded together with the vial, thereby rendering a less cumbersome -and lighter remaining assembly so as to facilitate the administration of a drug.
A further difference between the fluid control devices 34 and resides in the fact the former includes a dispensing port 38 fashioned as a male Luer connector.
Figures 12-15 depict a third embodiment of a fluid control device, generally designated 40, constructed and operative in accordance 10 with the teachings of the present invention for enabling fluid flow control between a syringe, a medicinal vessel and a dispensing port. The fluid control device 40 is similar in construction and operation to the fluid control device 10 and therefore the same reference numerals are used where appropriate.
The main difference between the two fluid control devices 40 and 10 resides in the fact that the former includes an adaptor 41 designed for a non-destructive detachable engagement with a flow control member 42. As such, the base member 11 is provided with a downwardly depending rectangular shaped skirt 43 provided with outwardly extending flanges 43' and 43" for engagement by an upwardly extending rectangular shaped grip 44 of the adaptor 41 provided with inwardly directed grooves 44' and 44" for receiving the flanges 43' and 43". In addition, the adaptor 41 is provided with . an upwardly extending stem 46 provided with a rectangular shaped key 46' for insertion into a similarly sized and shaped slot 42' formed in the underside of the flow control member 42.
In the fluid control device 40, the flow control member 42 is disposed in its first flow control position enabling a flow path between the port 12 and a medicinal vessel to be attached to the adaptor 41 when the adaptor 41 is mounted on the base member 11. Conversely, on the rotation of the adaptor 41 relative to the base member 11 to a position enabling axial detachment therefrom, the adaptor 41 urges the flow control member 42 from its first flow control position to its second flow control position enabling a flow path between the port 12 and the dispensing port 13. Preferably, there is a screw thread engagement between the base member 11 and the adaptor 41 designed such that there is an axial displacement of the adaptor 41 away from the base member llwhen it is rotated from its engaging position to its diseitgaging position.
It can be readily appreciated that -the advantage_ of,this design over the design of the fluid control device 34 whilst retaining all the advantages of the latter resides in the fact that the former is reusable after sterilization whilst the latter can only be used once due to the destruction of the adaptor cum flow control member 35.
A further difference between the fluid control devices 40 and 10 resides in the fact the former includes a dispensing port 13 provided with a needle 47.
Figures 16A and 16B depict a fourth embodiment of a fluid control device, generally designated 48, constructed and operative in accordance with the teachings of the present invention for enabling fluid flow control between a syringe, a medicinal vessel and a dispensing port.
The fluid control device 48 is similar in construction and operation to the fluid control device 41 and therefore the same reference numerals are used where appropriate.
The main difference between the two fluid control devices 48 and 41 resides in the fact that the former includes a flow control member 49 which is required to be rotated through a 180 turn between its first flow control position (see Figure 16A) and its second flow control position (see Figure 16B). In particular, the flow control member 49 includes an inclined channel 50 having a radial aperture 50' for registration with the interior opening 14' and an axial aperture 50" for registration with the fluid conduit member 24 so as to enable the flow path between a syringe and the interior of a medicinal vessel. And, the flow control member 49 includes a second inclined channel 52 having a radial aperture 52' for registration with the interior opening 14' and a radial aperture 52" for registration with the interior opening 16' so as to enable the flow path between a syringe to the dispensing port 13. As shown, in this case, the lumens 14 and 16 are not co-axial.
Figures 17-19 depict other modified fluid control devices, - generally designated 53, 54 and 55, constructed and operative in accordance with the teachings -of the present invention for enabling fluid flow control between a syringe, a medicinal vessel and. a dispensing port The fluid control device 53, 54 and 55 are similar in construction and operation to the fluid control device 41 and therefore the same reference numerals are used where appropriate. The main difference between the fluid control devices 53, 54 and 55 and the fluid control device 41 is that they provide arrangements for venting a vial and, if necessary, for filtering incoming air.
Turning now to Figure 17, the fluid control device 53 includes an adaptor 56 provided with a venting conduit 58 for venting a vial 28 to the atmosphere in addition to the fluid conduit member 24. The venting conduit 58 is preferably provided with a filter 59 for filtering incoming air. Turning now to Figures 18a and 18b, the fluid control device 54 is similar to the fluid control device 53 except that it includes a filter 60 exterior to the adaptor 56. Turning now to Figure 19, the fluid control device 55 is similar to the fluid control device 53 except that its adaptor 61 includes an integrally formed laterally disposed filter 62.
Figures 20-22 depict a fluid control device, generally designated 64, for enabling the reconstitution of a powder drug with a physiologi'cal solution contained in a medicinal vessel instead of within a pre-filled syringe as required with the fluid control device 10. The fluid control device 64 is similar in construction and operation to the fluid control device 41 and therefore the same reference numerals are used where appropriate.
The main difference between the two fluid control devices 64 and 41 resides in the fact that the former is adapted to be fitted with two medicinal vessels and, as such, its base member 11 is provided with a port 12, a dispensing port 13 and two bores 17A and 17B which are WO 96/29113 PGT/f7S96103732 interconnected by a channel 65. As shown, the medicinal vessels are vials 28A and 28B where the vial 28A contains the powdered drug and the vial 28B contains the physiological solution for diluting the powdered drug.
As explained in greater detail hereinbelow for the case when the vial 28A has its contents under" a high vacuum, the sequence and order of the attachment of the vials 28A and 28B to the adapters 41A and 41B is not arbitrary.
In this case, the flow control member 42A has a first flow control position in which its L-shaped flow duct 23A registers in flow communication with the channel 65 and a medicinal vessel attached to its adaptor 41A (see Figures 20 and 21) and a second flow control position in which its peripheral groove flow duct 25A registers in flow communication with the channel 65 and the dispensing port 13 (see Figure 22). In contrast, the flow control member 42B has a first flow control position in which its L-shaped flow duct 23B registers in flow communication with the channel 65 and a medicinal vessel attached to its adaptor 41B (see Figure 20) and a second flow control position in which its peripheral groove flow duct 25B registers in flow communication with the channel 65 and. the port 12 (see Figures 21 and 22).
The operation of the fluid control device 64 for the administration of a powder drug provided in the pressurized vial 28A
after reconstitution with a physiological solution_ provided in the vial 28B
is now described. First, as shown in Figure 20, the fluid control device 64 is provided in its first operative position, namely, enabling the flow path between the vials 28A and 28B when they are attached to the base member 11. It should be noted that the vial 28B is attached to the adaptor 41B and thereafter the pressurized vial 28A is attached to the adaptor 41A such that the physiological solution contents of the vial 41B
is sucked into the vial 28A. Reconstitution typically requires shaking the fluid control device 64. As shown in Figure 21, the adaptor 41B together with the vial 28B are then rotated so as to enable their detachment from the base member 11 whilst, at the same tiine, effecting the rotation of the _ 15_ flow control member 42B so as to enable a flow path between the port 12 and the remaining vial 28 A. A syringe 66 is inserted into the port 12 and, after inversion of the fluid control device 64 such that the vial 28 containing the reconstituted drug assumes an upward position, the syringe 66 is aspirated to draw the contents of the vial 28A thereinto. Thereafter, as shown in Figure 22, the adaptor 41A together with the vial 28A are rotated so as to enable their detachment from the base member 11 while, at the same time, effecting the rotation of the flow control member 42A
so as to enable a flow path between the syringe 66 and the dispensing port 13. Finally, in this position, the syringe 66 is actuated so as to express the drug for its administration to a patient via the dispensing port 13.
Figures 23-25 depicts a fluid control device 67 allowing the preparation of a drug by the mixing between a first substance contained in a first medicinal vessel and a second substance contained in a second medicinal vessel and thereafter the transfer of the drug to a dispensing tool, namely, a syringe. The fluid control device 67 includes a base member 68 having a generally tubular intermediate portion 70 defining a lumen 71 in which a flow control member 72 is rotatably inserted. The flow control member 72 has a port 73 for receiving a dispensing tool, typically, a syringe 74 (see Figure 25). The port 73 is preferably fashioned as a female Luer connector. The flow control member 72 also has integrally formed handles 76 for enabling a manual rotating thereof.
As shown, a filter 77 can also be deployed within the port 73 for filtering a drug on its aspiration into a syringe 74.
The base member 68 includes two adapters 78 and 79 which are adapted for the attachment thereto of medicinal vessels. In this case, the adapters 78 and 79 are adapted for the attachment thereto of vials and, as such, they include respective co-axial fluid conduit members 78' and 79' fashioned as piercing tools for puncturing the vials' rubber stoppers.
The fluid conduit members 78' and 79' have respective internal apertures 78" and 79".
. 16-The flow control member 72 is rotatably mounted for enabling either, in a first flow control position, a flow path between vials attached to the adapters 78 and 79 or, in a second flow control position, a flow path between a syringe and one of the vials. As such, in a similar manner to the flow control member 20' (see Figures 3 and 4), flow control -member 72 includes two flow ducts as follows: A first flow duct 80 in the form of a peripheral groove slightly longer than semi-circular having end portions 80' and 80" for registration with the interior apertures 78" and 79" so as to enable a flow path between the interiors of vials when attached to the adapters 78 and 79. And a second flow duct 82 in the form of an L-shaped channel having a radial aperture 82' for registration with the interior opening 71' and an axial outlet port 82" so as to enable a flow path between a vial attached to one of the adapters 78 and 79 and a syringe inserted in the port 77.
The operation of the fluid control device 67 is now described with reference to the steps depicted in Figure 25 for the case that a vial 83 contains a dried drug, e.g. a powder, a crystalline material, a lyophilizate, etc., stored under a high vacuum and a vial 84 contains a physiological solution. As explained in greater detail hereinbelow for the case when the vial 83 has its contents under a high vacuum, the sequence of attachment of the vials 83 and 84 to the adapters 78 and 79 is not arbitrary.
The fluid control device 67 is typically provided in a hermetically sealed package with its flow control member 72 set so as to enable the flow path between flow conduit members 78' and 79' by means of the ends 80' and 80" of its semi-circular groove 80 registering with their interior openings 78" and 79" (Fig. 25A). The vial 84 containing the diluent solution is attached to the adaptor 78 (Fig. 25B), the action of attachment puncturing its rubber stopper and thereafter the vial 83 containing the dried drug is attached to the adaptor 79 (Fig. 25C) thereby sucking the diluent solution thereinto once its rubber stopper is punctured (Fig. 25D). The contents of the vial 83 are then shaken so as to mix the diluent solution with the dried drug.
The syringe 74 is inserted into the port 73 (Fig. 25D) and the flow control member 72 is rotated through a quarter turn relative to the base member 11 such that the flow path between the. syringe 74 and the vial 83 is enabled (Fig. 25E). The fltiid control device 67 is.then inverted (Fig. 25F) and the syringe 74 is aspirated so as to draw the reconstituted drug thereinto, the medicinal preparation passing through a deployed filter 77, if any, thereby becoming particle free for administration to a patient.
Figures 26 and 27 depict the fluid control device 67 with a modified flow control member 85 having just the L-shaped flow duct 82, thereby requiring that it be rotated through a 180 turn for switching between its two flow control positions, the first flow control position being between a syringe inserted in the port 73 and a first medicinal vessel whilst the second flow control position being between a syringe inserted in the port 73 and a second medicinal vessel.
The difference between the flow control member 85 and 72 being that a fluid control device 67 fitted with the former can be employed with medicinal vessels in which their contents are under a low vacuum or no vacuum, thereby requiring user intervention to perform the mixing of the powder drug with the physiological solution. In particular, the flow control member 85 is suitable for use with a fluid control device 67 having an adaptor suitable for connection to an=IV bag .25 such that on setting the flow control member 85 in its first operative position, the syringe 74 is aspirated so as to introduce a predetermined volume of diluent solution thereinto. Thereafter, on setting the flow control member 85 into its second operative position, the syringe 74 is actuated so as to introduce the diluent solution into a second medicinal vessel containing the drug to be reconstituted. After mixing of the drug with the diluent solution, the syringe 74 is aspirated a second time so as to introduce the medicinal liquid thereinto at which time the syringe 74 is removed for administration of the drug to a patient. In this fashion, such a fluid control device can be used a number of times with one or more medicinal vessels.
Figure 28 depicts a fluid control device 86 with a port 87 provided with an integral 'in-line filter 88, thereby obviating the need for a filter 77. Figure 29 depicts a fluid control device 89 with a modified adaptor 90 having a vent conduit 91 for venting the vial attached thereto provided with a hydrophobic filter 92- so as to prevent wastage of the mixed drug when the fluid control device 89 is manipulated into the position shown in Fig. 25F.
While the invention has been described with respect to a limited number of embodiments, it will be appreciated that many variations, modifications and other applications of the invention may be made.
The invention relates to fluid control devices in general and in particular to fluid control devices adapted for facilitating the aseptic administration of drugs to patients.
BACKGROUND OF THE INVENTION
Drugs intended for parenteral administration are typically stored in a medicinal vessel either as a dry powder or as a solution. The solution can be ready for immediate use or in the form of a liquid concentrate which requires reconstitution with a physiological solution prior to administration in a similar manner to a dry powder drug. The physiological solution can be provided in a pre-filled syringe or a medicinal vessel.
Medicinal vessels typically fall into one of three categories.
The first type is a vial or a glass bottle closed by a rubber stopper which can be penetrated by a puncturing tool, for example, a needle, and which is self-closing upon withdrawal of the puncturing tool. Such a vial or glass bottle can contain a single dose or a multiple dose of a drug. The drug contained in a vial can be under a high vacuum. The second type is an ampoule whose top portion is broken off enabling access to its contents. The third type is an IV bag provided with a sample port for enabling access to its contents. The sample port can be of the pre-slit septum type.
Regardless of the manner in which a drug is stored, there is a need to transfer fluid under sterile conditions before its administration to a patient by a dispensing tool be it a needle, a pre-slit septum, or the like. When a prior dilution of a s drug is required, the process requires at least two fluid transfers. The problem of ensuring proper fluid transfer under aseptic conditions is especially acute in the case of self-administration of drugs by patients in their homes.
Assemblies which have hitherto been proposed for the aseptic administration of drugs are described in U.S. Patent Nos: Des. 271,421, 3,618,637, lo 3,757,981, 3,826,261, 3,957,052, 3,977,555, 3,993,063, 4,051,852, 4,564,054, 4,604,093, 4,721,133, 4,758,235, 4,967,797, 4,997,430, 5,201,705, 5,269,768, 5,279,576, 5,288,290, 5,334,163, and 5,466,220, and European Publication Nos:0258913A2,0195018B1,0192661Bi,and0416454B1.
In particular, EP 0 521 460 B 1 describes a fluid control device for use 15 with a syringe and a pair of medicinal vessels. The fluid control device includes a housing with a Luer-connector port for receiving the syringe and second and third ports each comprising an adaptor having a fluid conduit member extending into the interior of a medicinal vessel when attached thereto. In the housing, a flow control member is slidingly displaceable from a first flow control position enabling a flow path between 20 the two medicinal vessels when connected and a second flow control position enabling a flow path between one of the medicinal vessels and the syringe.
- 2a -SUMMARY OF THE INVENTION
An object of some embodiments of the invention is to provide a fluid control device enabling the aseptic administration of drugs.
According to the present invention, there is provided a fluid control device for use with a syringe and at least one medicinal vessel, the fluid control device comprising: a first port, a second port for receiving the syringe, a third port comprising an adaptor having a fluid conduit member extending into the interior of the medicinal vessel when attached thereto, and a flow control member displaceable between first and second flow control positions respectively enabling flow paths between the second and third ports in the first flow control position and the second and first ports in the second flow control position, wherein the third port is coupled to the flow control member, and is rotationally displaceable between first and second control positions, whereby rotation of the third port rotates the flow control member between its first and second flow control positions.
Also according to the present invention, there is provided a fluid control device for use with a syringe and at least one medicinal vessel, the fluid control device comprising: a first port, a second port for receiving the syringe, a third port comprising an adaptor having a fluid conduit member extending into the interior of the medicinal vessel when attached thereto, and a flow control member displaceable between first and second flow control positions respectively enabling flow paths between the first and third ports in the first flow control position and the second and third ports in the second flow control position, wherein the second port is coupled to the flow control member, and is - 2b -rotationally displaceable between first and second control positions, whereby rotation of the second port rotates the flow control member between its first and second flow control positions.
According to the present invention, there is further provided a fluid control device for use with a syringe and at least one medicinal vessel, the fluid control device comprising: a first port, a second port for receiving the syringe, a third port comprising an adaptor having a fluid conduit member extending into the interior of the medicinal vessel when attached thereto, and a flow control member displaceable between first and second flow control positions respectively enabling flow paths between the first and second ports in the first flow control position and the second and third ports in the second flow control position, wherein the second port is coupled to the flow control member, and is rotationally displaceable between first and second control positions, whereby rotation of the second port rotates the flow control member between its first and second flow control positions.
According to the present invention, there is further provided a fluid control device for use with a syringe and at least one medicinal vessel, the fluid control device comprising: at least three ports including a first port; a second port for receiving the syringe; a third port comprising an adaptor having a fluid conduit member extending into the interior of the medicinal vessel when attached thereto; and a fluid control member displaceable between first and second flow control positions respectively enabling flow paths between first and second pairs of said at least three ports; wherein one of the second and third ports is coupled to the flow control member and is rotatably displaceable between first and second control positions - 2c -whereby rotation of the port correspondingly rotates the flow control member between its first and second flow control position.
_ 3 _ In accordance with some embodiments of the present invention, there is provided a family of fluid control devices which are adapted for the aseptic administration of drugs either directly or indirectly to a patient.
The selection of the most suitable fluid control device depends on the type of drug to be administered to a patient, the manner in which it is packaged, the manner in which it is to be administered to a patient and by whom apart from other factors. Some of the devices are designed to enable the reconstitution of a drug provided in a powder form or as a liquid concentrate. Some of the devices are suited for vials or ampoules containing a single dose of a drug whilst others are suited for vials or IV
bags containing multiple doses.
In some embodiments of a fluid control device, the flow control member is rotatably mounted in a body member so as to be selectively rotatable between its first flow control position and its second flow control position.
In some embodiments of a fluid control device, the first port is adapted for dispensing a drug directly or indirectly to a patient and, as such, it can be provided with a needle, it can be fashioned as a male Luer connector on which a needle can be mounted or it can be fashioned as a plastic cannula for insertion into a pre-slit septum. ' In such an embodiment, the adaptor may be coupled to a flow control member adapted for rotation in a body member having the port adapted for receiving a syringe and the dispensing port.
The adaptor can be integrally formed with the flow control member and designed so as to readily broken off therefrom after rotation of the flow control member from its first flow control position to its second flow control position. Alternatively, the adaptor can be detachably engaged to the flow control member by rneans of an interengaging means enabling axial detachment of the adaptor from the body member on a relative rotation therebetween to a position which urges the flow control member from its first flow control position to its second flow control position.
In some embodiments of a fluid control device suitable for use with drugs which require reconstitution, the fluid control device includes a fourth port in the form of an adaptor for enabling the attachment of a second medicinal vessel to the body member..
In some -embodiments of a fluid control device, the first port is also provided with an adaptor adapted for attachment thereto of a medicinal vessel and, in this case, the port adapted for receiving the syringe is rotatably coupled to the flow control member.
In each case, the adaptor can be adapted for attachment thereto of a vial, an ampoule or an IV bag, the former requiring that the fluid conduit member be formed as a puncturing tool for piercing the vial's rubber stopper on its attachment thereto. In the case of attachment of an ampoule, because the ampoule cannot be inverted, the fluid conduit member is required to be provided as a long straw to enable all or nearly all of its contents to be aspirated therefrom.
The adaptor can also include a conduit for venting the vessel when attached thereto. The conduit can include a filter for filtering the air traversing therethrough. The filter can be deployed within a lateral cavity provided within the adaptor or, alternately, the filter can be provided as a discrete element exterior to the fluid control device.
BRIEF DESCRIPTION OF THE DRAWINGS
For a better understanding of embodiments of the invention and to show how the same may be carried out in practice, and solely by way of non-limiting examples, reference will now be made to the accompanying drawings, in which:
Fig. I is a perspective view of an assembled fluid control device including a base member and an integrally formed adaptor cum flow control member for use with a syringe and a medicinal vessel;
Fig. 2 is a perspective view of the fluid control device of Figure 1 before assembly;
Fig. 3 is a vertical cross sectional view of the fluid control device of Figure 1 along the line A-A after insertion of a syringe and the attachment of a vial and before rotation of the adaptor relative to the 'base member;
Fig. 4 is a horizontal cross sectional view of the fluid control device of Figure 1 along the line B-B after insertion of a syringe and the attachment of a vial and before rotation of the adaptor relative to the base member;
Fig. 5 is a horizontal cross sectional view of the fluid control device of Figure 1 along the line C-C before rotation of the adaptor relative to the base member;
Fig. 6 is a vertical cross sectional view of the fluid control device of Figure 1 along the line A-A after rotation of the adaptor relative to the base member;
Fig. 7 is a horizontal cross sectional view of the fluid control device of Figure 1 along the line B-B after rotation of the adaptor relative to the base member;
Fig. 8 is a horizontal cross sectional view of the fluid control device of Figure 1 along the line C-C before rotation of the adaptor relative to the base member;
Fig. 9 is a perspective view of a modified integrally formed adaptor cum flow control member adapted such that the adaptor breaks off from the flow control member on rotation of the adaptor relative to the base member beyond a pre-determined position;
Fig. 10 is a perspective view of a fluid control device including the modified adaptor cum flow 'control member of Figure 9 after the adaptor has been broken off;
Fig. 11 is a perspective view of an assembled fluid control device including a base member and an adaptor designed for releasable engagement with 'the base member;
_6- -Fig. 12 is a perspective view of the fluid control device of Figure 11 after the adaptor has been rotated through a quarter turn ready for its detachment from the base member;
Fig. 13 is a vertical cross sectional view of the base member of the fluid control device of Figure 11; -Fig. 14 is a vertical cioss sectional view of the, adaptor of the fluid control device of Figure 11;
Fig. 15 is a perspective view of the flow control member of the fluid control device of Figure 11;
Figs. 16A and 16B are vertical cross sectional views of a fluid control device in which the flow control member is required to be rotated through 180 to enable switching between its flow control position;
Fig. 17 is a vertical cross sectional view of a fluid control device provided with an arrangement for the venting of a vial attached to its adaptor;
Figs. 18A and 18B are two views depicting a fluid control device having a filter for filtering air venting a vial attached to its adaptor, the filter being provided as a discrete element exterior to the device;
Fig. 19 is a vertical cross sectional view of a fluid control device having an adaptor provided with a lateral cavity for receiving a filter for filtering air venting a vial attached thereto;
Fig. 20 is a vertical cross-sectional view of a fluid control device in a first operative position enabling flow communication between a medicinal vessel containing a powder drug and a medicinal vessel containing -a physiological solution for enabling reconstitution of the powder drug;
Fig. 21 is a vertical cross sectional view of the fluid control device of Figure 20 in a second operative position enabling flow communication between the vial containing the .reconstituted drug and a syringe;
.7.-Fig. 22 is a vertical cross sectional view of the fluid control device of Figure 20 in a third operative position enabling flow communication between the syringe and a dispensing port;
'Fig. 23 is a longitudinal cross sectional view of a fluid control device for use with a syringe and a pair of.medicinal vessels;
Fig. 24 is a horizontal cross sectional view of the flow control member of the fluid control device of Figure 23 along line D-D;
Fig. 25 shows a series of steps (Figures 25A-25F) depicting the operation of the fluid control device of Figure 23;
Fig. 26 is a longitudinal cross sectional view of the fluid control device of Figure 23 with a modified flow control member;
Fig. 27 is a horizontal cross sectional view of the flow control member of Figure 26 along line E-E in Figure 26;
Fig. 28 is a longitudinal cross sectional view of a modified fluid control device of Figure 23 with an in-line filter; and Fig. 29 is a longitudinal cross sectional view of a fluid control device with a modified adaptor enabling venting of a medicinal vessel attached thereto fitted with a hydrophobic filter.
DETAILED DESCRIPTION OF THE DRAWINGS
Figures 1-8 depict a first embodiment of a fluid control device, generally designated 10, constructed and operative in accordance with the teachings of the present invention for enabling fluid flow coritrol between a syringe, a medicinal vessel and a dispensing port. The fluid control device 10 includes an elongated base member 11 having a port 12 adapted for receiving a syringe and a dispensing port 13 fashioned as a plastic cannula for insertion into a pre-slit septum assembly known in the art per se. The port 12 is typically fashioned as a female Luer connector.
As shown in Figure 3; the port 12 includes a lumen 14 having an interior opening 14' and the dispensing port 13 includes a lumen 16 having an interior opening 16'. The lumens 14 and 16 are co-axial and in flow communication via a bore 17 transversely disposed relative to the elongated base member 11. The bore 17 includes an upper peripheral flange 18 and a lower minor peripheral abutment wall portion 19' protruding radially inward relative to its major peripheral wall portion 19" (see Figure 5). As shown, the abutment wall portion 19' typically extends through an arc angle of about 90 .
The fluid control device 10 further includes -an integrally formed adaptor cum flow control member, generally designated 20, for insertion into the bore 17 in which it is restrained therein by means of a peripherally formed groove 22 designed for receiving the flange 18 therein. The flow control member 20' is formed with two flow ducts as follows: A first flow duct 23 (see Figure 3) in the form of an L-shaped channel having a radial aperture 23' for registration with the interior opening 14' and an axial aperture 23' of a fluid conduit member 24 integrally formed as part of the adaptor 20" on disposition of the flow control member 20' in a first flow control position enabling flow communication between a syringe inserted in the port 12 and a vessel attached to the adaptor 20". A second flow duct 25 (see Figure 4) in the form of a peripheral slightly longer than a semi-circular groove 25 having a first end portion 25' for registration with one of the interior openings 14' and 16' and a second end portion 25" for registration with the other of the interior openings 14' and 16' on disposition of the flow control member 20' in a second flow control position enabling flow communication between a syringe inserted in the port 12 and the dispensing port 13.
In addition, the flow control member 20' is provided with a minor peripheral abutment wall portion 26' protruding radially outward relative to its major peripheral wall portion 26" (see Figure 5). As shown, the abutment wall portion 26' typically extends through an arc angle of about 90 . The minor peripheral abutment wall portions 19' and 26' are so disposed such that they assume substantially diagonally opposing positions relative to one another (see Figure 5) in the first flow control position of the flow control member 20'.
The adaptor 20" is shown to be adapted for the attachment ti thereto of a vial 28 (not drawn to size) provided with a rubber stopper 29.
As such, the fluid conduit member 24 is fashioned as a puncturing tool 30 for penetrating a rubber stopper 29 on attachment of a vial 28 to its adaptor 20". Alternatively, the adaptor 20" can be adapted for the attachrrient thereto of an ampoule 31 (not drawn to size), the difference being that such an adaptor will preferably have relatively long springy grips.
Each stage of the two stage operation of the fluid control device 10 for the administration of a drug provided in powder form for dilution with a physiological solution provided in a pre-filled syringe is now described with reference to Figures 3-5 and Figures 6-8, respectively.
As shown in Figure 3-5, the fluid control device 10 is best provided in a set-up position in which the flow control member 20' is in its first flow control position and the two minor abutment wall portions 19' and 26' are diagonally opposed to one another. As shown, it should be noted as best seen in Figure 4, that the semi-circular groove 25 registers with the interior opening 16' but does not provide a flow path.
In this arrangement, a pre-filled syringe 32 is inserted into the port 12 and the vial 28 is attached to the adaptor 20" by means of which action, the puncturing tool 30 punctures the vial's rubber stopper 29, thereby enabling flow communication with its interior via the fluid conduit member 24. Typically, the syringe 32 requires actuation ' for expressing its contents into the vial 28 whilst, in some cases, if the contents of the vial 28 are under vacuum, then the physiological solution of the syringe 32 can be sucked into the vial without user intervention.
Thereafter, the contents of the vial 28 are shaken so as to reconstitute the powdered drug. The fluid control device 10 together with the vial 28 are then preferably inverted and the syringe 32 is aspirated so as to draw the reconstituted liquid drug thereinto.
Turning now to Figures. 6-8; the vial 28 together with the adaptor 20" are rotated in either a clockwise or a counter clockwise direction relative to the base member 11 until such time that abutment wall portion 26' is stopped by the abutment wall portion 19' (see Figure 8). On rotation of the adaptor 20", the flow control member 20' is rotated to its second flow control position enabling a flow path between the syringe 32 and the dispensing port 13 by means of the end portions 25' and 25" of the semi-circular groove 25 registering with the interior openings 14' and 16'. The drug can then be dispensed by actuation of the syringe 32.
It can now be readily appreciated that the fluid control device 10 ensures that a drug can be administered to a patient under aseptic conditions. Furthermore, it can be readily appreciated that the fluid control device 10 presents a "fool-proof' delivery device in the sense that a patient is required to perform a minimal number of actions to administer a drug and that the drug can only be dispensed in a single operative position of the fluid control device.
Figures 9 and 10 depict a second embodiment of a fluid control device, generally designated 34, constructed and operative in accordance with the teachings of the present invention for enabling fluid flow control between a syringe, a medicinal vessel and a dispensing port. The fluid control device 34 is similar in construction and operation to the fluid control device 10 and therefore the same reference numbers are used where appropriate.
The main difference between the two fluid control devices 34 and 10 resides in the fact that the former includes an integrally formed adaptor cum flow control member 35 provided with a weakened portion, generally designated 36, between its abutment wall portion 26' of its flow control member 35' and its adaptor 35". As shown, this weakened portion 36 is achieved by leaving radially extending vanes 36' formed by cut-outs 36".
The advantage of this design is that after rotation of the vial 28 (not shown) and the adaptor 35" through 90 so as to rotate the flow control member 35' from its first flow control position to its second flow control position, any further torque applied will tend to snap off the adaptor 35" which can then be discarded together with the vial, thereby rendering a less cumbersome -and lighter remaining assembly so as to facilitate the administration of a drug.
A further difference between the fluid control devices 34 and resides in the fact the former includes a dispensing port 38 fashioned as a male Luer connector.
Figures 12-15 depict a third embodiment of a fluid control device, generally designated 40, constructed and operative in accordance 10 with the teachings of the present invention for enabling fluid flow control between a syringe, a medicinal vessel and a dispensing port. The fluid control device 40 is similar in construction and operation to the fluid control device 10 and therefore the same reference numerals are used where appropriate.
The main difference between the two fluid control devices 40 and 10 resides in the fact that the former includes an adaptor 41 designed for a non-destructive detachable engagement with a flow control member 42. As such, the base member 11 is provided with a downwardly depending rectangular shaped skirt 43 provided with outwardly extending flanges 43' and 43" for engagement by an upwardly extending rectangular shaped grip 44 of the adaptor 41 provided with inwardly directed grooves 44' and 44" for receiving the flanges 43' and 43". In addition, the adaptor 41 is provided with . an upwardly extending stem 46 provided with a rectangular shaped key 46' for insertion into a similarly sized and shaped slot 42' formed in the underside of the flow control member 42.
In the fluid control device 40, the flow control member 42 is disposed in its first flow control position enabling a flow path between the port 12 and a medicinal vessel to be attached to the adaptor 41 when the adaptor 41 is mounted on the base member 11. Conversely, on the rotation of the adaptor 41 relative to the base member 11 to a position enabling axial detachment therefrom, the adaptor 41 urges the flow control member 42 from its first flow control position to its second flow control position enabling a flow path between the port 12 and the dispensing port 13. Preferably, there is a screw thread engagement between the base member 11 and the adaptor 41 designed such that there is an axial displacement of the adaptor 41 away from the base member llwhen it is rotated from its engaging position to its diseitgaging position.
It can be readily appreciated that -the advantage_ of,this design over the design of the fluid control device 34 whilst retaining all the advantages of the latter resides in the fact that the former is reusable after sterilization whilst the latter can only be used once due to the destruction of the adaptor cum flow control member 35.
A further difference between the fluid control devices 40 and 10 resides in the fact the former includes a dispensing port 13 provided with a needle 47.
Figures 16A and 16B depict a fourth embodiment of a fluid control device, generally designated 48, constructed and operative in accordance with the teachings of the present invention for enabling fluid flow control between a syringe, a medicinal vessel and a dispensing port.
The fluid control device 48 is similar in construction and operation to the fluid control device 41 and therefore the same reference numerals are used where appropriate.
The main difference between the two fluid control devices 48 and 41 resides in the fact that the former includes a flow control member 49 which is required to be rotated through a 180 turn between its first flow control position (see Figure 16A) and its second flow control position (see Figure 16B). In particular, the flow control member 49 includes an inclined channel 50 having a radial aperture 50' for registration with the interior opening 14' and an axial aperture 50" for registration with the fluid conduit member 24 so as to enable the flow path between a syringe and the interior of a medicinal vessel. And, the flow control member 49 includes a second inclined channel 52 having a radial aperture 52' for registration with the interior opening 14' and a radial aperture 52" for registration with the interior opening 16' so as to enable the flow path between a syringe to the dispensing port 13. As shown, in this case, the lumens 14 and 16 are not co-axial.
Figures 17-19 depict other modified fluid control devices, - generally designated 53, 54 and 55, constructed and operative in accordance with the teachings -of the present invention for enabling fluid flow control between a syringe, a medicinal vessel and. a dispensing port The fluid control device 53, 54 and 55 are similar in construction and operation to the fluid control device 41 and therefore the same reference numerals are used where appropriate. The main difference between the fluid control devices 53, 54 and 55 and the fluid control device 41 is that they provide arrangements for venting a vial and, if necessary, for filtering incoming air.
Turning now to Figure 17, the fluid control device 53 includes an adaptor 56 provided with a venting conduit 58 for venting a vial 28 to the atmosphere in addition to the fluid conduit member 24. The venting conduit 58 is preferably provided with a filter 59 for filtering incoming air. Turning now to Figures 18a and 18b, the fluid control device 54 is similar to the fluid control device 53 except that it includes a filter 60 exterior to the adaptor 56. Turning now to Figure 19, the fluid control device 55 is similar to the fluid control device 53 except that its adaptor 61 includes an integrally formed laterally disposed filter 62.
Figures 20-22 depict a fluid control device, generally designated 64, for enabling the reconstitution of a powder drug with a physiologi'cal solution contained in a medicinal vessel instead of within a pre-filled syringe as required with the fluid control device 10. The fluid control device 64 is similar in construction and operation to the fluid control device 41 and therefore the same reference numerals are used where appropriate.
The main difference between the two fluid control devices 64 and 41 resides in the fact that the former is adapted to be fitted with two medicinal vessels and, as such, its base member 11 is provided with a port 12, a dispensing port 13 and two bores 17A and 17B which are WO 96/29113 PGT/f7S96103732 interconnected by a channel 65. As shown, the medicinal vessels are vials 28A and 28B where the vial 28A contains the powdered drug and the vial 28B contains the physiological solution for diluting the powdered drug.
As explained in greater detail hereinbelow for the case when the vial 28A has its contents under" a high vacuum, the sequence and order of the attachment of the vials 28A and 28B to the adapters 41A and 41B is not arbitrary.
In this case, the flow control member 42A has a first flow control position in which its L-shaped flow duct 23A registers in flow communication with the channel 65 and a medicinal vessel attached to its adaptor 41A (see Figures 20 and 21) and a second flow control position in which its peripheral groove flow duct 25A registers in flow communication with the channel 65 and the dispensing port 13 (see Figure 22). In contrast, the flow control member 42B has a first flow control position in which its L-shaped flow duct 23B registers in flow communication with the channel 65 and a medicinal vessel attached to its adaptor 41B (see Figure 20) and a second flow control position in which its peripheral groove flow duct 25B registers in flow communication with the channel 65 and. the port 12 (see Figures 21 and 22).
The operation of the fluid control device 64 for the administration of a powder drug provided in the pressurized vial 28A
after reconstitution with a physiological solution_ provided in the vial 28B
is now described. First, as shown in Figure 20, the fluid control device 64 is provided in its first operative position, namely, enabling the flow path between the vials 28A and 28B when they are attached to the base member 11. It should be noted that the vial 28B is attached to the adaptor 41B and thereafter the pressurized vial 28A is attached to the adaptor 41A such that the physiological solution contents of the vial 41B
is sucked into the vial 28A. Reconstitution typically requires shaking the fluid control device 64. As shown in Figure 21, the adaptor 41B together with the vial 28B are then rotated so as to enable their detachment from the base member 11 whilst, at the same tiine, effecting the rotation of the _ 15_ flow control member 42B so as to enable a flow path between the port 12 and the remaining vial 28 A. A syringe 66 is inserted into the port 12 and, after inversion of the fluid control device 64 such that the vial 28 containing the reconstituted drug assumes an upward position, the syringe 66 is aspirated to draw the contents of the vial 28A thereinto. Thereafter, as shown in Figure 22, the adaptor 41A together with the vial 28A are rotated so as to enable their detachment from the base member 11 while, at the same time, effecting the rotation of the flow control member 42A
so as to enable a flow path between the syringe 66 and the dispensing port 13. Finally, in this position, the syringe 66 is actuated so as to express the drug for its administration to a patient via the dispensing port 13.
Figures 23-25 depicts a fluid control device 67 allowing the preparation of a drug by the mixing between a first substance contained in a first medicinal vessel and a second substance contained in a second medicinal vessel and thereafter the transfer of the drug to a dispensing tool, namely, a syringe. The fluid control device 67 includes a base member 68 having a generally tubular intermediate portion 70 defining a lumen 71 in which a flow control member 72 is rotatably inserted. The flow control member 72 has a port 73 for receiving a dispensing tool, typically, a syringe 74 (see Figure 25). The port 73 is preferably fashioned as a female Luer connector. The flow control member 72 also has integrally formed handles 76 for enabling a manual rotating thereof.
As shown, a filter 77 can also be deployed within the port 73 for filtering a drug on its aspiration into a syringe 74.
The base member 68 includes two adapters 78 and 79 which are adapted for the attachment thereto of medicinal vessels. In this case, the adapters 78 and 79 are adapted for the attachment thereto of vials and, as such, they include respective co-axial fluid conduit members 78' and 79' fashioned as piercing tools for puncturing the vials' rubber stoppers.
The fluid conduit members 78' and 79' have respective internal apertures 78" and 79".
. 16-The flow control member 72 is rotatably mounted for enabling either, in a first flow control position, a flow path between vials attached to the adapters 78 and 79 or, in a second flow control position, a flow path between a syringe and one of the vials. As such, in a similar manner to the flow control member 20' (see Figures 3 and 4), flow control -member 72 includes two flow ducts as follows: A first flow duct 80 in the form of a peripheral groove slightly longer than semi-circular having end portions 80' and 80" for registration with the interior apertures 78" and 79" so as to enable a flow path between the interiors of vials when attached to the adapters 78 and 79. And a second flow duct 82 in the form of an L-shaped channel having a radial aperture 82' for registration with the interior opening 71' and an axial outlet port 82" so as to enable a flow path between a vial attached to one of the adapters 78 and 79 and a syringe inserted in the port 77.
The operation of the fluid control device 67 is now described with reference to the steps depicted in Figure 25 for the case that a vial 83 contains a dried drug, e.g. a powder, a crystalline material, a lyophilizate, etc., stored under a high vacuum and a vial 84 contains a physiological solution. As explained in greater detail hereinbelow for the case when the vial 83 has its contents under a high vacuum, the sequence of attachment of the vials 83 and 84 to the adapters 78 and 79 is not arbitrary.
The fluid control device 67 is typically provided in a hermetically sealed package with its flow control member 72 set so as to enable the flow path between flow conduit members 78' and 79' by means of the ends 80' and 80" of its semi-circular groove 80 registering with their interior openings 78" and 79" (Fig. 25A). The vial 84 containing the diluent solution is attached to the adaptor 78 (Fig. 25B), the action of attachment puncturing its rubber stopper and thereafter the vial 83 containing the dried drug is attached to the adaptor 79 (Fig. 25C) thereby sucking the diluent solution thereinto once its rubber stopper is punctured (Fig. 25D). The contents of the vial 83 are then shaken so as to mix the diluent solution with the dried drug.
The syringe 74 is inserted into the port 73 (Fig. 25D) and the flow control member 72 is rotated through a quarter turn relative to the base member 11 such that the flow path between the. syringe 74 and the vial 83 is enabled (Fig. 25E). The fltiid control device 67 is.then inverted (Fig. 25F) and the syringe 74 is aspirated so as to draw the reconstituted drug thereinto, the medicinal preparation passing through a deployed filter 77, if any, thereby becoming particle free for administration to a patient.
Figures 26 and 27 depict the fluid control device 67 with a modified flow control member 85 having just the L-shaped flow duct 82, thereby requiring that it be rotated through a 180 turn for switching between its two flow control positions, the first flow control position being between a syringe inserted in the port 73 and a first medicinal vessel whilst the second flow control position being between a syringe inserted in the port 73 and a second medicinal vessel.
The difference between the flow control member 85 and 72 being that a fluid control device 67 fitted with the former can be employed with medicinal vessels in which their contents are under a low vacuum or no vacuum, thereby requiring user intervention to perform the mixing of the powder drug with the physiological solution. In particular, the flow control member 85 is suitable for use with a fluid control device 67 having an adaptor suitable for connection to an=IV bag .25 such that on setting the flow control member 85 in its first operative position, the syringe 74 is aspirated so as to introduce a predetermined volume of diluent solution thereinto. Thereafter, on setting the flow control member 85 into its second operative position, the syringe 74 is actuated so as to introduce the diluent solution into a second medicinal vessel containing the drug to be reconstituted. After mixing of the drug with the diluent solution, the syringe 74 is aspirated a second time so as to introduce the medicinal liquid thereinto at which time the syringe 74 is removed for administration of the drug to a patient. In this fashion, such a fluid control device can be used a number of times with one or more medicinal vessels.
Figure 28 depicts a fluid control device 86 with a port 87 provided with an integral 'in-line filter 88, thereby obviating the need for a filter 77. Figure 29 depicts a fluid control device 89 with a modified adaptor 90 having a vent conduit 91 for venting the vial attached thereto provided with a hydrophobic filter 92- so as to prevent wastage of the mixed drug when the fluid control device 89 is manipulated into the position shown in Fig. 25F.
While the invention has been described with respect to a limited number of embodiments, it will be appreciated that many variations, modifications and other applications of the invention may be made.
Claims (13)
1. A fluid control device for use with a syringe and at least one medicinal vessel, the fluid control device comprising:
- a first port, - a second port for receiving the syringe, - a third port comprising an adaptor having a fluid conduit member extending into the interior of the medicinal vessel when attached thereto, - and a flow control member displaceable between first and second flow control positions respectively enabling flow paths between the second and third ports in the first flow control position and the second and first ports in the second flow control position, wherein - the third port is coupled to the flow control member, and is rotationally displaceable between first and second control positions, whereby rotation of the third port rotates the flow control member between its first and second flow control positions.
- a first port, - a second port for receiving the syringe, - a third port comprising an adaptor having a fluid conduit member extending into the interior of the medicinal vessel when attached thereto, - and a flow control member displaceable between first and second flow control positions respectively enabling flow paths between the second and third ports in the first flow control position and the second and first ports in the second flow control position, wherein - the third port is coupled to the flow control member, and is rotationally displaceable between first and second control positions, whereby rotation of the third port rotates the flow control member between its first and second flow control positions.
2. A device according to claim 1, wherein said flow control member is coupled to said adaptor.
3. A device according to claim 2, wherein said adaptor is integrally formed with said flow control member, thereby constituting an integrally formed adaptor cum flow control member.
4. A device according to claim 3, wherein said integrally formed adaptor cum flow control member includes a weakened portion enabling a forced non-reversible detachment of said adaptor from said flow control member at the second control position.
5. A device according to claim 2, wherein said adaptor is coupled to said flow control member by interengaging means enabling a reversible screw-like detachment of said adaptor from said flow control member at the second control position.
6. A device according to any one of claims 1 to 5, wherein said adaptor further comprises a venting conduit extending into the interior of a medicinal vessel when attached thereto.
7. A device according to claim 6, wherein the venting conduit is provided with a filter element.
8. A fluid control device for use with a syringe and at least one medicinal vessel, the fluid control device comprising:
- a first port, - a second port for receiving the syringe, - a third port comprising an adaptor having a fluid conduit member extending into the interior of the medicinal vessel when attached thereto, - and a flow control member displaceable between first and second flow control positions respectively enabling flow paths between the first and third ports in the first flow control position and the second and third ports in the second flow control position, wherein - the second port is coupled to the flow control member, and is rotationally displaceable between first and second control positions, whereby rotation of the second port rotates the flow control member between its first and second flow control positions.
- a first port, - a second port for receiving the syringe, - a third port comprising an adaptor having a fluid conduit member extending into the interior of the medicinal vessel when attached thereto, - and a flow control member displaceable between first and second flow control positions respectively enabling flow paths between the first and third ports in the first flow control position and the second and third ports in the second flow control position, wherein - the second port is coupled to the flow control member, and is rotationally displaceable between first and second control positions, whereby rotation of the second port rotates the flow control member between its first and second flow control positions.
9. A fluid control device for use with a syringe and at least one medicinal vessel, the fluid control device comprising:
- a first port, - a second port for receiving the syringe, - a third port comprising an adaptor having a fluid conduit member extending into the interior of the medicinal vessel when attached thereto, - and a flow control member displaceable between first and second flow control positions respectively enabling flow paths between the first and second ports in the first flow control position and the second and third ports in the second flow control position, wherein - the second port is coupled to the flow control member, and is rotationally displaceable between first and second control positions, whereby rotation of the second port rotates the flow control member between its first and second flow control positions.
- a first port, - a second port for receiving the syringe, - a third port comprising an adaptor having a fluid conduit member extending into the interior of the medicinal vessel when attached thereto, - and a flow control member displaceable between first and second flow control positions respectively enabling flow paths between the first and second ports in the first flow control position and the second and third ports in the second flow control position, wherein - the second port is coupled to the flow control member, and is rotationally displaceable between first and second control positions, whereby rotation of the second port rotates the flow control member between its first and second flow control positions.
10. A device according to claim 8 or 9, wherein the first port also comprises an adaptor having a fluid conduit member extending into the interior of a medicinal vessel when attached thereto.
11. A device according to any one of claims 8 to 10, wherein the adaptor of the third port further comprises a venting conduit for venting the vessel when attached thereto provided with a filter.
12. A device according to any one of claims 8 to 11, wherein said second port further comprises an inline filter.
13. A fluid control device for use with a syringe and at least one medicinal vessel, the fluid control device comprising:
- at least three ports including:
- a first port;
- a second port for receiving the syringe;
- a third port comprising an adaptor having a fluid conduit member extending into the interior of the medicinal vessel when attached thereto; and - a fluid control member displaceable between first and second flow control positions respectively enabling flow paths between first and second pairs of said at least three ports; wherein - one of the second and third ports is coupled to the flow control member and is rotatably displaceable between first and second control positions whereby rotation of the port correspondingly rotates the flow control member between its first and second flow control position.
- at least three ports including:
- a first port;
- a second port for receiving the syringe;
- a third port comprising an adaptor having a fluid conduit member extending into the interior of the medicinal vessel when attached thereto; and - a fluid control member displaceable between first and second flow control positions respectively enabling flow paths between first and second pairs of said at least three ports; wherein - one of the second and third ports is coupled to the flow control member and is rotatably displaceable between first and second control positions whereby rotation of the port correspondingly rotates the flow control member between its first and second flow control position.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
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US40728795A | 1995-03-20 | 1995-03-20 | |
US08/407,287 | 1995-03-20 | ||
US49921395A | 1995-07-07 | 1995-07-07 | |
US08/499,213 | 1995-07-07 | ||
IL11496095A IL114960A0 (en) | 1995-03-20 | 1995-08-16 | Flow control device |
IL114960 | 1995-08-16 | ||
PCT/US1996/003732 WO1996029113A1 (en) | 1995-03-20 | 1996-03-19 | Fluid control device |
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CA2215752A1 CA2215752A1 (en) | 1996-09-26 |
CA2215752C true CA2215752C (en) | 2008-07-29 |
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Application Number | Title | Priority Date | Filing Date |
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CA 2215752 Expired - Lifetime CA2215752C (en) | 1995-03-20 | 1996-03-19 | Fluid control device |
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EP (1) | EP0814866B1 (en) |
JP (1) | JP3782453B2 (en) |
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AU (1) | AU5136696A (en) |
CA (1) | CA2215752C (en) |
DE (1) | DE69613461T2 (en) |
IL (2) | IL114960A0 (en) |
WO (1) | WO1996029113A1 (en) |
Families Citing this family (283)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL114960A0 (en) | 1995-03-20 | 1995-12-08 | Medimop Medical Projects Ltd | Flow control device |
WO1997020536A1 (en) * | 1995-12-06 | 1997-06-12 | Gabriel Meyer | Device for preparing a medicinal solution reconstituted from two components |
FR2749169B1 (en) | 1996-06-04 | 1998-08-21 | Delab | PROCESS FOR CONSTITUTING AN INJECTABLE PREPARATION AND DEVICE FOR CARRYING OUT SAID METHOD |
IT236231Y1 (en) | 1997-11-24 | 2000-08-08 | Eurospital S P A | CONNECTION DEVICE FOR TWO PHARMACEUTICAL PRODUCT CONTAINERS TO MIX THE PRODUCTS IN THE SYSTEM |
IT236233Y1 (en) | 1997-11-26 | 2000-08-08 | Eurospital S P A | DEVICE FOR THE CONNECTION OF A PHARMACEUTICAL PRODUCT CONTAINER TO A BAG OF LIQUID PRODUCT TO CARRY OUT THE |
US6568434B2 (en) | 1998-02-04 | 2003-05-27 | Omrix Biopharmaceuticals S.A. | Receiver cup for a vessel housing a medicinal substance |
US6357489B1 (en) * | 1998-02-04 | 2002-03-19 | Omrix Biopharmaceuticals S.A. | Device for storing a liquid medicinal substance and method for filling an applicator for a liquid medicinal substance by use of said storing device |
US6475183B1 (en) | 1998-06-03 | 2002-11-05 | Baxter International Inc. | Direct dual filling device for sealing agents |
AUPP676898A0 (en) * | 1998-10-26 | 1998-11-19 | Noble House Group Pty Ltd | Sampling first in blood collection |
AU751570B2 (en) * | 1998-10-26 | 2002-08-22 | Noble House Group Pty Ltd | Sampling in blood collection |
JP2002529204A (en) | 1998-11-13 | 2002-09-10 | エラン・フアルマ・インターナシヨナル・リミテツド | System and method for delivering chemicals |
US6355023B1 (en) * | 1999-11-15 | 2002-03-12 | Gaylord Hospital | Closed system access device |
WO2001041650A1 (en) * | 1999-12-08 | 2001-06-14 | Baxter International Inc. | Direct dual filling device for sealing agents |
DE19960504A1 (en) * | 1999-12-15 | 2001-08-16 | Curasan Ag | Regenerating agent |
DE19960490A1 (en) * | 1999-12-15 | 2001-07-12 | Curasan Ag | Regenerating agent |
JP4025961B2 (en) * | 2000-08-24 | 2007-12-26 | 日本軽金属株式会社 | Anaerobic opener for beverage containers |
JP4552969B2 (en) * | 2000-08-24 | 2010-09-29 | 日本軽金属株式会社 | Anaerobic opener for beverage containers |
JP2004508897A (en) * | 2000-09-21 | 2004-03-25 | エラン・ファルマ・インターナショナル・リミテッド | Reshaping and injection system |
US6474375B2 (en) * | 2001-02-02 | 2002-11-05 | Baxter International Inc. | Reconstitution device and method of use |
JP3820889B2 (en) | 2001-02-05 | 2006-09-13 | ニプロ株式会社 | Infusion container |
US20020143297A1 (en) * | 2001-03-30 | 2002-10-03 | Becton, Dickinson And Company | Adaptor for use with point-of-care testing cartridge |
JP4370552B2 (en) * | 2001-09-14 | 2009-11-25 | ニプロ株式会社 | Chemical solution injection port |
US6918893B2 (en) | 2001-10-04 | 2005-07-19 | Scimed Life Systems, Inc. | Multiple port fluid control valves |
US6989891B2 (en) | 2001-11-08 | 2006-01-24 | Optiscan Biomedical Corporation | Device and method for in vitro determination of analyte concentrations within body fluids |
GB0129176D0 (en) * | 2001-12-06 | 2002-01-23 | Dca Design Int Ltd | Improvements in and realting to a medicament cartridge assembly |
US8562583B2 (en) | 2002-03-26 | 2013-10-22 | Carmel Pharma Ab | Method and assembly for fluid transfer and drug containment in an infusion system |
US6644365B1 (en) | 2002-04-19 | 2003-11-11 | Baxter International, Inc. | Tilting direct dual filling device |
SE523001C2 (en) | 2002-07-09 | 2004-03-23 | Carmel Pharma Ab | Coupling component for transmitting medical substances, comprises connecting mechanism for releasable connection to second coupling component having further channel for creating coupling, where connecting mechanism is thread |
US9956377B2 (en) | 2002-09-20 | 2018-05-01 | Angiodynamics, Inc. | Method and apparatus for intra-aortic substance delivery to a branch vessel |
CA2513705A1 (en) | 2003-01-21 | 2004-08-05 | Carmel Pharma Ab | A needle for penetrating a membrane |
ES2397833T3 (en) * | 2003-03-05 | 2013-03-11 | Csl Behring Gmbh | Transfer device |
DE502004005171D1 (en) * | 2003-03-06 | 2007-11-22 | Csl Behring Gmbh | Transfer device, in particular for medical fluids |
US6948522B2 (en) | 2003-06-06 | 2005-09-27 | Baxter International Inc. | Reconstitution device and method of use |
JP3883527B2 (en) | 2003-07-17 | 2007-02-21 | ニプロ株式会社 | Transfer needle |
US7488297B2 (en) * | 2003-07-30 | 2009-02-10 | Patrice Flaherty | Blood collecting devices |
WO2005025640A2 (en) * | 2003-09-09 | 2005-03-24 | Wisconsin Alumni Research Foundation | Medical shunt/valve for regulatoin of bodily fluids |
US8210166B2 (en) * | 2003-12-16 | 2012-07-03 | Wolfe Tory Medical, Inc. | Vial multi-access adapter |
US7794436B2 (en) * | 2004-01-13 | 2010-09-14 | Lloyd Jay Pinel | Controlled gastric bolus feeding device |
IL160891A0 (en) | 2004-03-16 | 2004-08-31 | Auto-mix needle | |
US9022036B2 (en) | 2004-03-31 | 2015-05-05 | Fisher & Paykel Healthcare Limited | Patient ventilating and aspirating system |
IL161660A0 (en) * | 2004-04-29 | 2004-09-27 | Medimop Medical Projects Ltd | Liquid drug delivery device |
FR2869533B1 (en) * | 2004-05-03 | 2006-07-28 | Sedat Sa | SYRINGE FOR MEDICAL INTERVENTIONS AND NECESSARY FOR RECONSTITUTION OF EXTEMPORANEOUS SUBSTANCES COMPRISING SUCH A SYRINGE |
EP2808586B1 (en) | 2004-09-03 | 2019-05-22 | Elcam Medical Agricultural Cooperative Association Ltd. | Stopcock |
US20060064070A1 (en) * | 2004-09-07 | 2006-03-23 | Jeffrey Martin | Methods and devices for sterile field transfer |
US7731678B2 (en) | 2004-10-13 | 2010-06-08 | Hyprotek, Inc. | Syringe devices and methods for mixing and administering medication |
US7785332B2 (en) * | 2004-10-29 | 2010-08-31 | Depuy Products, Inc. | Method of delivering therapeutic implant |
WO2006058153A1 (en) * | 2004-11-23 | 2006-06-01 | Smith & Nephew, Inc. | Composite mixer |
US7935070B2 (en) | 2005-01-28 | 2011-05-03 | Fresenius Medical Care North America | Systems and methods for dextrose containing peritoneal dialysis (PD) solutions with neutral pH and reduced glucose degradation product |
ES2354018T3 (en) | 2005-02-14 | 2011-03-09 | Medimop Medical Projects Ltd. | MEDICAL DEVICE FOR THE IN SITU RECONSTITUTION OF LIQUID DRUGS IN MEDICINAL CONTAINERS. |
US20070060904A1 (en) * | 2005-03-14 | 2007-03-15 | Becton, Dickinson And Company | Filling system and method for syringes with short needles |
EP1714642A1 (en) | 2005-04-18 | 2006-10-25 | Bracco Research S.A. | Pharmaceutical composition comprising gas-filled microcapsules for ultrasound mediated delivery |
CA2603033A1 (en) * | 2005-04-29 | 2006-11-09 | Wyeth | Drug delivery devices and related components, systems and methods |
DK1919432T3 (en) * | 2005-08-11 | 2012-01-30 | Medimop Medical Projects Ltd | Liquid Medication Transfer Devices for Safe Safe Resting Connection on Medical Vials |
US7882863B2 (en) * | 2005-10-19 | 2011-02-08 | Cd Solutions, Llc | Apparatus and method for mixing and transferring medications |
US8137307B2 (en) | 2005-11-09 | 2012-03-20 | Hyprotek, Inc. | Syringe devices, components of syringe devices, and methods of forming components and syringe devices |
DE602005013301D1 (en) | 2005-11-22 | 2009-04-23 | Omrix Biopharm Sa | APPLICATOR DEVICE FOR APPLYING A MULTICOMPONENT LIQUID |
US20070119508A1 (en) * | 2005-11-29 | 2007-05-31 | West Richard L | Fluid Flow Diversion Valve and Blood Collection System Employing Same |
EP1797919A1 (en) | 2005-12-16 | 2007-06-20 | Bracco Research S.A. | Liquid transfer device for medical dispensing containers |
DE102006005533B4 (en) * | 2006-02-07 | 2008-04-17 | Sartorius Stedim Biotech Gmbh | Connector system and method for sterile connection |
US20070202186A1 (en) | 2006-02-22 | 2007-08-30 | Iscience Interventional Corporation | Apparatus and formulations for suprachoroidal drug delivery |
IL174352A0 (en) * | 2006-03-16 | 2006-08-20 | Medimop Medical Projects Ltd | Medical devices for use with carpules |
US7547300B2 (en) | 2006-04-12 | 2009-06-16 | Icu Medical, Inc. | Vial adaptor for regulating pressure |
DE102006022307A1 (en) * | 2006-05-11 | 2007-11-15 | Respironics Novametrix, LLC, Wallingford | Disposable bioreactor with sensor arrangement |
ES2425579T3 (en) * | 2006-05-25 | 2013-10-16 | Bayer Healthcare, Llc | Reconstitution device |
WO2008006660A1 (en) * | 2006-07-13 | 2008-01-17 | Novo Nordisk A/S | A drug mixing and infusion device |
WO2008020447A1 (en) | 2006-08-18 | 2008-02-21 | Medingo Ltd. | Methods and devices for delivering fluid to a reservoir of a fluid delivery device |
CA2662847A1 (en) * | 2006-09-07 | 2008-03-13 | Wyeth | Bone cement mixing systems and related methods |
JP2006326368A (en) * | 2006-09-19 | 2006-12-07 | Nipro Corp | Transfer needle |
US7981090B2 (en) | 2006-10-18 | 2011-07-19 | Baxter International Inc. | Luer activated device |
US8221363B2 (en) | 2006-10-18 | 2012-07-17 | Baxter Healthcare S.A. | Luer activated device with valve element under tension |
US7753338B2 (en) | 2006-10-23 | 2010-07-13 | Baxter International Inc. | Luer activated device with minimal fluid displacement |
WO2008067506A1 (en) * | 2006-11-30 | 2008-06-05 | Medi-Physics, Inc. | Dual-lumen needle |
US7883499B2 (en) | 2007-03-09 | 2011-02-08 | Icu Medical, Inc. | Vial adaptors and vials for regulating pressure |
US9149573B2 (en) | 2007-03-16 | 2015-10-06 | Smiths Medical Asd, Inc. | Blunt cannula for accessing a slit septum |
US7942860B2 (en) | 2007-03-16 | 2011-05-17 | Carmel Pharma Ab | Piercing member protection device |
ES2590762T3 (en) * | 2007-03-30 | 2016-11-23 | Instrumentation Laboratory Company | Sample vial adapter |
US8109236B2 (en) * | 2007-04-05 | 2012-02-07 | Sumitomo Corporation Of America | Fluid delivery assembly |
US8668400B2 (en) * | 2007-04-05 | 2014-03-11 | The Hartz Mountain Corporation | Fluid applicator |
IL182605A0 (en) | 2007-04-17 | 2007-07-24 | Medimop Medical Projects Ltd | Fluid control device with manually depressed actuator |
IL182922A0 (en) * | 2007-05-02 | 2007-09-20 | Medimop Medical Projects Ltd | Automatic liquid drug reconstitution apparatus |
US7975733B2 (en) | 2007-05-08 | 2011-07-12 | Carmel Pharma Ab | Fluid transfer device |
WO2008144575A2 (en) | 2007-05-18 | 2008-11-27 | Optiscan Biomedical Corporation | Fluid injection and safety system |
US8029747B2 (en) * | 2007-06-13 | 2011-10-04 | Carmel Pharma Ab | Pressure equalizing device, receptacle and method |
US8657803B2 (en) * | 2007-06-13 | 2014-02-25 | Carmel Pharma Ab | Device for providing fluid to a receptacle |
US8622985B2 (en) | 2007-06-13 | 2014-01-07 | Carmel Pharma Ab | Arrangement for use with a medical device |
US20080308081A1 (en) * | 2007-06-18 | 2008-12-18 | Ernest George Geros | Disposable gas system for internal combustion engine |
WO2009026443A2 (en) | 2007-08-21 | 2009-02-26 | Gilero, Llc | Vial access and injection system |
US10398834B2 (en) | 2007-08-30 | 2019-09-03 | Carmel Pharma Ab | Device, sealing member and fluid container |
US8287513B2 (en) | 2007-09-11 | 2012-10-16 | Carmel Pharma Ab | Piercing member protection device |
US8827978B2 (en) * | 2007-09-17 | 2014-09-09 | Carmel Pharma Ab | Bag connector |
CN101918074B (en) | 2007-09-18 | 2013-02-27 | 麦迪麦珀医疗工程有限公司 | Medicament mixing and injection apparatus |
IL186290A0 (en) * | 2007-09-25 | 2008-01-20 | Medimop Medical Projects Ltd | Liquid drug delivery devices for use with syringe having widened distal tip |
BRPI0817907B8 (en) | 2007-10-02 | 2021-06-22 | Lamodel Ltd | apparatus for administering a substance to an individual |
US9522097B2 (en) | 2007-10-04 | 2016-12-20 | Hyprotek, Inc. | Mixing/administration syringe devices, protective packaging and methods of protecting syringe handlers |
US8002737B2 (en) | 2007-10-04 | 2011-08-23 | Hyprotek, Inc. | Mixing/administration syringe devices, protective packaging and methods of protecting syringe handlers |
WO2009060419A2 (en) * | 2007-11-08 | 2009-05-14 | Elcam Medical A.C.A..L. Ltd | Vial adaptor and manufacturing method therfor |
CA2646265A1 (en) * | 2007-12-20 | 2009-06-20 | Tyco Healthcare Group Lp | Cap assembly for use with a prefilled lock solution syringe |
IL188975A0 (en) * | 2008-01-23 | 2008-11-03 | Medimop Medical Projects Ltd | Fluid control device with stopper |
US20090218535A1 (en) * | 2008-02-27 | 2009-09-03 | Andres Pasko | Flow controllers for fluid circuits |
CA2720233A1 (en) * | 2008-04-01 | 2009-12-03 | Yukon Medical, Llc | Dual container fluid transfer device |
WO2009126720A1 (en) * | 2008-04-08 | 2009-10-15 | West Pharmaceutical Services, Inc. | Fluid control device having a safety needle |
CA2630561C (en) * | 2008-04-30 | 2014-07-08 | Medical Systems | Contrast media injector kit |
US8075550B2 (en) | 2008-07-01 | 2011-12-13 | Carmel Pharma Ab | Piercing member protection device |
WO2010022095A1 (en) | 2008-08-20 | 2010-02-25 | Icu Medical, Inc. | Anti-reflux vial adaptors |
US8556879B2 (en) * | 2008-11-25 | 2013-10-15 | Jms Co., Ltd. | Connector |
WO2010061743A1 (en) * | 2008-11-25 | 2010-06-03 | 株式会社ジェイ・エム・エス | Connector |
US8523838B2 (en) | 2008-12-15 | 2013-09-03 | Carmel Pharma Ab | Connector device |
US8790330B2 (en) | 2008-12-15 | 2014-07-29 | Carmel Pharma Ab | Connection arrangement and method for connecting a medical device to the improved connection arrangement |
US9332969B2 (en) * | 2009-01-06 | 2016-05-10 | Carefusion 207, Inc. | Fluid flow control apparatus and patient fluid sampling method |
US8162914B2 (en) * | 2009-02-10 | 2012-04-24 | Kraushaar Timothy Y | Cap adapters for medicament vial and associated methods |
EP2398394B1 (en) | 2009-02-20 | 2021-08-04 | Omrix Biopharmaceuticals Ltd. | Device for administering an at least two-component substance |
USD641080S1 (en) | 2009-03-31 | 2011-07-05 | Medimop Medical Projects Ltd. | Medical device having syringe port with locking mechanism |
AU2010236426B2 (en) | 2009-04-14 | 2013-08-29 | Yukon Medical, Llc | Fluid transfer device |
CN102458516B (en) | 2009-05-04 | 2014-06-25 | 瓦莱里塔斯公司 | Fluid transfer device |
DE102009023676B4 (en) * | 2009-06-03 | 2016-01-07 | Jan Willem Marinus Mijers | Device for the application of fluid medicaments |
CN104721898B (en) * | 2009-07-01 | 2018-05-18 | 弗雷塞尼斯医疗保健控股公司 | Drug delivery device and related system and method |
USD616984S1 (en) | 2009-07-02 | 2010-06-01 | Medimop Medical Projects Ltd. | Vial adapter having side windows |
IL199767A0 (en) | 2009-07-09 | 2010-04-15 | Medimop Medical Projects Ltd | Medical device for use with cartridge and vial |
CN102724946B (en) | 2009-07-29 | 2015-06-10 | Icu医学有限公司 | Fluid transfer devices and methods of use |
USD630732S1 (en) | 2009-09-29 | 2011-01-11 | Medimop Medical Projects Ltd. | Vial adapter with female connector |
IL201323A0 (en) | 2009-10-01 | 2010-05-31 | Medimop Medical Projects Ltd | Fluid transfer device for assembling a vial with pre-attached female connector |
USD657056S1 (en) | 2009-10-02 | 2012-04-03 | Medline Industries, Inc. | Medical port |
US8764731B2 (en) * | 2009-10-02 | 2014-07-01 | Medline Industries, Inc. | Connector for fluid conduit with integrated luer access port |
US9662271B2 (en) | 2009-10-23 | 2017-05-30 | Amgen Inc. | Vial adapter and system |
DE102009051945A1 (en) * | 2009-11-04 | 2011-05-05 | Fresenius Medical Care Deutschland Gmbh | Drug delivery adapter with gas barrier element for a hemodialysis tube set |
IL202071A0 (en) | 2009-11-12 | 2010-06-16 | Medimop Medical Projects Ltd | Module for screw threading syringe onto syringe port |
IL202069A0 (en) | 2009-11-12 | 2010-06-16 | Medimop Medical Projects Ltd | Fluid transfer device with sealing arrangement |
IL202070A0 (en) | 2009-11-12 | 2010-06-16 | Medimop Medical Projects Ltd | Inline liquid drug medical device |
USD637713S1 (en) * | 2009-11-20 | 2011-05-10 | Carmel Pharma Ab | Medical device adaptor |
JP5716037B2 (en) | 2009-11-20 | 2015-05-13 | カルメル ファルマ アクチボラゲット | Medical instrument connector |
US8480646B2 (en) | 2009-11-20 | 2013-07-09 | Carmel Pharma Ab | Medical device connector |
US8597232B2 (en) | 2009-12-23 | 2013-12-03 | Medimop Medical Projects, Ltd. | Medical apparatus and single use kit including linear flow control device for use therewith for reconstitution and administration of liquid drug dosage |
US8070723B2 (en) * | 2009-12-31 | 2011-12-06 | Medtronic Minimed, Inc. | Activity guard |
CN102711712B (en) * | 2010-02-24 | 2014-08-13 | 麦迪麦珀医疗工程有限公司 | Fluid transfer assembly with venting arrangement |
JP5709905B2 (en) | 2010-02-24 | 2015-04-30 | メディモップ・メディカル・プロジェクツ・リミテッド | Liquid transfer device including vial adapter with vent |
CH702815A1 (en) * | 2010-03-10 | 2011-09-15 | Medmix Systems Ag | Filling device for filling at least one first reservoir of an applicator. |
CA2790050C (en) * | 2010-03-23 | 2021-04-20 | Hyperbranch Medical Technology, Inc. | Disposable syringe applicators for multi-component formulations, and methods of use thereof |
WO2011132657A1 (en) * | 2010-04-20 | 2011-10-27 | テルモ株式会社 | Liquid-medicine dosing device |
US9168203B2 (en) | 2010-05-21 | 2015-10-27 | Carmel Pharma Ab | Connectors for fluid containers |
US8162013B2 (en) | 2010-05-21 | 2012-04-24 | Tobias Rosenquist | Connectors for fluid containers |
USD655017S1 (en) | 2010-06-17 | 2012-02-28 | Yukon Medical, Llc | Shroud |
US8721627B2 (en) | 2010-07-22 | 2014-05-13 | Carefusion 303, Inc. | Needleless valve infection prevention and pre-opening device |
US9585810B2 (en) | 2010-10-14 | 2017-03-07 | Fresenius Medical Care Holdings, Inc. | Systems and methods for delivery of peritoneal dialysis (PD) solutions with integrated inter-chamber diffuser |
USD669980S1 (en) | 2010-10-15 | 2012-10-30 | Medimop Medical Projects Ltd. | Vented vial adapter |
IL209102A0 (en) * | 2010-11-04 | 2011-01-31 | Medimop Medical Projects Ltd | Inline liquid drug medical device with handle operated flow control member |
IL209290A0 (en) * | 2010-11-14 | 2011-01-31 | Medimop Medical Projects Ltd | Inline liquid drug medical device having rotary flow control member |
EP4015022A1 (en) | 2010-12-06 | 2022-06-22 | AktiVax, Inc. | Aseptic cartridge |
EP2465558A1 (en) | 2010-12-17 | 2012-06-20 | Weibel CDS AG | Device for removing a liquid from a container |
US20120157964A1 (en) * | 2010-12-21 | 2012-06-21 | Haimi Shlomo Uri | Device and method for the delivery of medicinal liquid directly from a small bottle (vial) |
US8398611B2 (en) | 2010-12-28 | 2013-03-19 | Depuy Mitek, Inc. | Compositions and methods for treating joints |
US8524662B2 (en) | 2010-12-28 | 2013-09-03 | Depuy Mitek, Llc | Compositions and methods for treating joints |
US8455436B2 (en) | 2010-12-28 | 2013-06-04 | Depuy Mitek, Llc | Compositions and methods for treating joints |
CN106880493B (en) | 2011-01-17 | 2021-03-12 | 阿克蒂夫帕克股份有限公司 | Aseptic cartridge and dispenser device |
WO2012110057A1 (en) | 2011-02-15 | 2012-08-23 | Chemisches Institut Schaefer Ag | Cefuroxime safety kit |
GB2492941A (en) * | 2011-03-02 | 2013-01-23 | Owen Mumford Ltd | An apparatus for filling a syringe |
EP2680807B1 (en) * | 2011-03-04 | 2016-08-10 | Duoject Medical Systems Inc. | Easy linking transfer system |
JP2012200437A (en) * | 2011-03-25 | 2012-10-22 | Terumo Corp | Multi-way cock and liquid medicine administration implement |
WO2012135315A1 (en) | 2011-03-31 | 2012-10-04 | Amgen Inc. | Vial adapter and system |
JP5807838B2 (en) * | 2011-04-12 | 2015-11-10 | ニプロ株式会社 | Drug preparation device |
IL212420A0 (en) | 2011-04-17 | 2011-06-30 | Medimop Medical Projects Ltd | Liquid drug transfer assembly |
WO2012146670A1 (en) * | 2011-04-28 | 2012-11-01 | Sanofi-Aventis Deutschland Gmbh | Dispense interface with lockout element |
CN103635215A (en) * | 2011-05-06 | 2014-03-12 | 赛诺菲-安万特德国有限公司 | Active valve for drug delivery |
IL213783A0 (en) | 2011-06-27 | 2011-07-31 | Medimop Medical Projects Ltd | Medical apparatus and single use kit including linear flow control device for use therewith for reconstitution and administration of liquid drug dosage |
US8623839B2 (en) | 2011-06-30 | 2014-01-07 | Depuy Mitek, Llc | Compositions and methods for stabilized polysaccharide formulations |
AU2012296495B2 (en) | 2011-08-18 | 2016-03-10 | Icu Medical, Inc. | Pressure-regulating vial adaptors |
USD681230S1 (en) | 2011-09-08 | 2013-04-30 | Yukon Medical, Llc | Shroud |
IL215699A0 (en) | 2011-10-11 | 2011-12-29 | Medimop Medical Projects Ltd | Liquid drug reconstitution assemblage for use with iv bag and drug vial |
IL217091A0 (en) | 2011-12-19 | 2012-02-29 | Medimop Medical Projects Ltd | Vial adapter for use with syringe having widened distal syringe tip |
ES2945322T3 (en) | 2011-12-22 | 2023-06-30 | Icu Medical Inc | Fluid Transfer Devices and Methods of Use |
DK2802377T3 (en) | 2012-01-13 | 2017-03-20 | Icu Medical Inc | Pressure regulating bottle adapter and method |
SG192310A1 (en) | 2012-02-02 | 2013-08-30 | Becton Dickinson Holdings Pte Ltd | Adaptor for coupling to a medical container |
USD737436S1 (en) | 2012-02-13 | 2015-08-25 | Medimop Medical Projects Ltd. | Liquid drug reconstitution assembly |
USD674088S1 (en) | 2012-02-13 | 2013-01-08 | Medimop Medical Projects Ltd. | Vial adapter |
USD720451S1 (en) | 2012-02-13 | 2014-12-30 | Medimop Medical Projects Ltd. | Liquid drug transfer assembly |
WO2013128444A1 (en) * | 2012-03-02 | 2013-09-06 | Medeq Llc | Two way fluid control device |
WO2013132414A1 (en) | 2012-03-09 | 2013-09-12 | Sensile Pat Ag | Drug reconstitution system |
AU2013204180B2 (en) | 2012-03-22 | 2016-07-21 | Icu Medical, Inc. | Pressure-regulating vial adaptors |
IL219065A0 (en) | 2012-04-05 | 2012-07-31 | Medimop Medical Projects Ltd | Fluid transfer device with manual operated cartridge release arrangement |
US10143797B2 (en) * | 2012-04-09 | 2018-12-04 | Becton, Dickinson And Company | Injection mechanism utilizing a vial |
USD769444S1 (en) | 2012-06-28 | 2016-10-18 | Yukon Medical, Llc | Adapter device |
US20150182699A1 (en) * | 2012-07-05 | 2015-07-02 | Dali Medical Devices Ltd | Syringe extension |
IL221635A0 (en) | 2012-08-26 | 2012-12-31 | Medimop Medical Projects Ltd | Drug vial mixing and transfer device for use with iv bag and drug vial |
IL221634A0 (en) | 2012-08-26 | 2012-12-31 | Medimop Medical Projects Ltd | Universal drug vial adapter |
BR112015005157B1 (en) | 2012-09-13 | 2020-12-08 | Medimop Medical Projects Ltd | telescopic female drug bottle adapter |
EP2897673B1 (en) | 2012-09-24 | 2020-01-22 | Medline Industries, Inc. | Power injector device and method of use |
EP2735300A1 (en) | 2012-11-26 | 2014-05-28 | Becton Dickinson France | Adaptor for multidose medical container |
USD734868S1 (en) | 2012-11-27 | 2015-07-21 | Medimop Medical Projects Ltd. | Drug vial adapter with downwardly depending stopper |
US9724269B2 (en) | 2012-11-30 | 2017-08-08 | Becton Dickinson and Company Ltd. | Connector for fluid communication |
US11369739B2 (en) | 2013-01-21 | 2022-06-28 | Medline Industries, Lp | Method to provide injection system parameters for injecting fluid into patient |
DK2948125T3 (en) | 2013-01-23 | 2019-08-19 | Icu Medical Inc | PRESSURE REGULATING VAPE ADAPTERS |
US9089475B2 (en) | 2013-01-23 | 2015-07-28 | Icu Medical, Inc. | Pressure-regulating vial adaptors |
EP4223339A1 (en) | 2013-03-14 | 2023-08-09 | Fisher & Paykel Healthcare Limited | Catheter mount with suction port |
US9414990B2 (en) | 2013-03-15 | 2016-08-16 | Becton Dickinson and Company Ltd. | Seal system for cannula |
US10022301B2 (en) | 2013-03-15 | 2018-07-17 | Becton Dickinson and Company Ltd. | Connection system for medical device components |
IL225734A0 (en) | 2013-04-14 | 2013-09-30 | Medimop Medical Projects Ltd | Ready-to-use drug vial assemblages including drug vial and drug vial closure having fluid transfer member, and drug vial closure therefor |
WO2014179698A2 (en) | 2013-05-03 | 2014-11-06 | Clearside Biomedical, Inc. | Apparatus and methods for ocular injection |
DK2983745T3 (en) | 2013-05-10 | 2018-10-22 | West Pharma Services Il Ltd | Medical devices comprising ampoule adapter with interconnected module for dry drug |
RU2531650C2 (en) * | 2013-06-24 | 2014-10-27 | Владимир Алексеевич Небольсин | Dual-chamber disposable syringe |
US9321545B2 (en) | 2013-07-09 | 2016-04-26 | Pharmac, Llc | Apparatus for mixing and transferring medications |
AU2014290124B2 (en) | 2013-07-19 | 2019-05-09 | Icu Medical, Inc. | Pressure-regulating fluid transfer systems and methods |
US10688295B2 (en) | 2013-08-07 | 2020-06-23 | West Pharma. Services IL, Ltd. | Liquid transfer devices for use with infusion liquid containers |
USD765837S1 (en) | 2013-08-07 | 2016-09-06 | Medimop Medical Projects Ltd. | Liquid transfer device with integral vial adapter |
USD767124S1 (en) | 2013-08-07 | 2016-09-20 | Medimop Medical Projects Ltd. | Liquid transfer device with integral vial adapter |
CA2921233A1 (en) * | 2013-08-13 | 2015-02-19 | Noble House Group Pty. Ltd. | Universal sampling cap |
EP3057635B1 (en) | 2013-10-18 | 2019-12-18 | Infusion Innovations, Inc. | Fluid transfer devices, systems, and methods for their use in delivering medical fluids |
US9636278B2 (en) | 2013-11-06 | 2017-05-02 | Becton Dickinson and Company Limited | System for closed transfer of fluids with a locking member |
CA2929478C (en) | 2013-11-06 | 2019-07-02 | Becton Dickinson and Company Limited | Connection apparatus for a medical device |
EP3065694B1 (en) | 2013-11-06 | 2020-04-29 | Becton Dickinson and Company Limited | System for closed transfer of fluids having connector |
CN105848707B (en) | 2013-11-06 | 2020-06-16 | 贝克顿·迪金森有限公司 | Medical connector with locking engagement |
EP3073982B1 (en) | 2013-11-25 | 2020-04-08 | ICU Medical, Inc. | Methods and system for filling iv bags with therapeutic fluid |
US20150273121A1 (en) * | 2014-03-26 | 2015-10-01 | William Olivero | Suction cleaning device |
EP3125774B1 (en) | 2014-04-04 | 2020-05-27 | HyperBranch Medical Technology, Inc. | Extended tip spray applicator for two-component surgical selant, and methods of use thereof |
US9186493B2 (en) | 2014-04-15 | 2015-11-17 | Advanced Scientific, Inc. | Aseptic connector |
CA2945533C (en) | 2014-04-16 | 2018-10-16 | Becton Dickinson and Company Limited | Fluid transfer device with axially and rotationally movable portion |
US9833605B2 (en) | 2014-04-21 | 2017-12-05 | Becton Dickinson and Company Limited | Fluid transfer device and packaging therefor |
EP3398583A1 (en) | 2014-04-21 | 2018-11-07 | Becton Dickinson and Company Limited | System with adapter for closed transfer of fluids |
ES2865138T3 (en) | 2014-04-21 | 2021-10-15 | Becton Dickinson & Co Ltd | Vial stabilizer base with attachable vial adapter |
JP6449910B2 (en) | 2014-04-21 | 2019-01-09 | ベクトン ディキンソン アンド カンパニー リミテッド | Fluid transfer device and packaging thereof |
EP4233827A3 (en) | 2014-04-21 | 2023-11-01 | Becton Dickinson and Company Limited | System for closed transfer of fluids |
EP3134053B1 (en) | 2014-04-21 | 2020-05-27 | Becton Dickinson and Company Limited | System for closed transfer of fluids and membrane arrangements for use thereof |
ES2689083T3 (en) | 2014-04-21 | 2018-11-08 | Becton Dickinson and Company Limited | Syringe adapter with combined decoupling movement |
EP4091597A1 (en) | 2014-04-21 | 2022-11-23 | Becton Dickinson and Company Limited | Syringe adapter with disconnection feedback mechanism |
EP3157491B1 (en) | 2014-06-20 | 2022-06-22 | ICU Medical, Inc. | Pressure-regulating vial adaptors |
DE102014213948B4 (en) | 2014-07-17 | 2021-09-23 | B. Braun Melsungen Aktiengesellschaft | Fluid connection system for medical purposes |
CN107073211B (en) | 2014-08-14 | 2021-01-05 | 韦贝尔Cds公司 | Syringe with selectable flow passage and seal |
USD757933S1 (en) | 2014-09-11 | 2016-05-31 | Medimop Medical Projects Ltd. | Dual vial adapter assemblage |
US10285907B2 (en) | 2015-01-05 | 2019-05-14 | West Pharma. Services IL, Ltd. | Dual vial adapter assemblages with quick release drug vial adapter for ensuring correct usage |
US9682099B2 (en) | 2015-01-20 | 2017-06-20 | DePuy Synthes Products, Inc. | Compositions and methods for treating joints |
JP6616840B2 (en) * | 2015-03-26 | 2019-12-04 | イネイブル インジェクションズ、インコーポレイテッド | Apparatus and method for drug delivery and resuspension powered by pressurized gas |
US10413662B2 (en) | 2015-05-14 | 2019-09-17 | Carefusion 303, Inc. | Priming apparatus and method |
US10357429B2 (en) | 2015-07-16 | 2019-07-23 | West Pharma. Services IL, Ltd. | Liquid drug transfer devices for secure telescopic snap fit on injection vials |
US20190083357A1 (en) | 2015-07-20 | 2019-03-21 | Medimop Medical Projects Ltd. | Liquid drug transfer device with set-up vial retention flex members |
US10576207B2 (en) | 2015-10-09 | 2020-03-03 | West Pharma. Services IL, Ltd. | Angled syringe patch injector |
CN112972833B (en) | 2015-10-09 | 2024-01-09 | 西医药服务以色列分公司 | Syringe needle cap remover |
USD801522S1 (en) | 2015-11-09 | 2017-10-31 | Medimop Medical Projects Ltd. | Fluid transfer assembly |
US11234899B2 (en) | 2017-05-11 | 2022-02-01 | Scalpal Llc | Grasping facilitators and uses thereof and kits involving the same |
WO2017090042A1 (en) | 2015-11-25 | 2017-06-01 | Medimop Medical Projects Ltd | Dual vial adapter assemblage including drug vial adapter with self-sealing access valve |
JP6710758B2 (en) | 2015-12-04 | 2020-06-17 | アイシーユー・メディカル・インコーポレーテッド | Electronic medical fluid transfer device for transferring medical fluid |
CN109219456B (en) | 2016-01-21 | 2020-05-15 | 西医药服务以色列有限公司 | Force containment in autoinjectors |
JP6885960B2 (en) | 2016-01-21 | 2021-06-16 | ウェスト ファーマ サービシーズ イスラエル リミテッド | Drug delivery device with visual indicators |
CN109310816B (en) | 2016-01-21 | 2020-04-21 | 西医药服务以色列有限公司 | Needle insertion and retraction mechanism |
WO2017132588A1 (en) | 2016-01-29 | 2017-08-03 | Icu Medical, Inc. | Pressure-regulating vial adaptors |
WO2017161076A1 (en) | 2016-03-16 | 2017-09-21 | Medimop Medical Projects Ltd. | Staged telescopic screw assembly having different visual indicators |
IL245803A0 (en) | 2016-05-24 | 2016-08-31 | West Pharma Services Il Ltd | Dual vial adapter assemblages including vented drug vial adapter and vented liquid vial adapter |
IL245800A0 (en) | 2016-05-24 | 2016-08-31 | West Pharma Services Il Ltd | Dual vial adapter assemblages including identical twin vial adapters |
GB2550924A (en) | 2016-05-31 | 2017-12-06 | Ndm Technologies Ltd | Improvements in or relating to transdermal delivery |
IL246073A0 (en) | 2016-06-06 | 2016-08-31 | West Pharma Services Il Ltd | Fluid transfer devices for use with drug pump cartridge having slidable driving plunger |
EP3254714B1 (en) * | 2016-06-08 | 2021-07-28 | SHL Medical AG | Device and system for dispensing a fluid under aseptic conditions |
US9956143B2 (en) * | 2016-06-14 | 2018-05-01 | Pharmac, Llc | Syringe apparatus for transferring liquids into and out of a vial having a septum |
GB2552193A (en) * | 2016-07-13 | 2018-01-17 | Ndm Technologies Ltd | Improvements in or relating to transdermal delivery |
USD851745S1 (en) | 2016-07-19 | 2019-06-18 | Icu Medical, Inc. | Medical fluid transfer system |
CA3031529A1 (en) | 2016-07-25 | 2018-02-01 | Icu Medical, Inc. | Systems, methods, and components for trapping air bubbles in medical fluid transfer modules and systems |
CN109562229B (en) | 2016-08-01 | 2021-07-13 | 西医药服务以色列有限公司 | Anti-rotation medicine barrel pin |
US10238326B2 (en) | 2016-08-04 | 2019-03-26 | Elcam Medical Agricultural Cooperative Association Ltd. | Flushable fluid handling assembly |
IL247376A0 (en) | 2016-08-21 | 2016-12-29 | Medimop Medical Projects Ltd | Syringe assembly |
USD851244S1 (en) | 2016-09-26 | 2019-06-11 | West Pharma. Services IL, Ltd. | Syringe barrel |
USD838367S1 (en) | 2016-09-26 | 2019-01-15 | West Pharma. Services IL, Ltd. | Syringe barrel |
CA3037577A1 (en) | 2016-09-30 | 2018-04-05 | Icu Medical, Inc. | Pressure-regulating vial access devices and methods |
USD832430S1 (en) | 2016-11-15 | 2018-10-30 | West Pharma. Services IL, Ltd. | Dual vial adapter assemblage |
IL249408A0 (en) | 2016-12-06 | 2017-03-30 | Medimop Medical Projects Ltd | Liquid transfer device for use with infusion liquid container and pincers-like hand tool for use therewith for releasing intact drug vial therefrom |
US11701301B2 (en) | 2017-03-06 | 2023-07-18 | All India Institute Of Medical Sciences (Aiims) | Device, method and kit for the reconstitution of a solid or semi solid pharmaceutical composition |
IL251458A0 (en) | 2017-03-29 | 2017-06-29 | Medimop Medical Projects Ltd | User actuated liquid drug transfer devices for use in ready-to-use (rtu) liquid drug transfer assemblages |
CN110869072B (en) | 2017-05-30 | 2021-12-10 | 西部制药服务有限公司(以色列) | Modular drive mechanism for a wearable injector |
KR102630666B1 (en) | 2017-06-22 | 2024-01-29 | 엘캠 메디컬 애그리컬처럴 코오퍼레이티브 어소시에이션 리미티드 | Closed stopcock |
WO2019015773A1 (en) * | 2017-07-20 | 2019-01-24 | Janssen Biotech, Inc. | Drug mixing device |
US11116696B2 (en) * | 2017-08-10 | 2021-09-14 | Baxter International Inc. | Reconstitution device, system, and method to administer a drug in a moderate bolus |
IL254802A0 (en) | 2017-09-29 | 2017-12-31 | Medimop Medical Projects Ltd | Dual vial adapter assemblages with twin vented female vial adapters |
EP3713620B1 (en) | 2017-11-21 | 2021-11-03 | Sanofi | Mixing and/or reconstitution system |
DE102018210931A1 (en) * | 2018-07-03 | 2020-01-09 | B. Braun Melsungen Aktiengesellschaft | Medical switching valve for a medical fluid line system |
JP1630477S (en) | 2018-07-06 | 2019-05-07 | ||
USD923812S1 (en) | 2019-01-16 | 2021-06-29 | West Pharma. Services IL, Ltd. | Medication mixing apparatus |
JP1648075S (en) | 2019-01-17 | 2019-12-16 | ||
EP3917486B1 (en) | 2019-01-31 | 2023-03-08 | West Pharma. Services IL, Ltd | Liquid transfer device |
KR102157609B1 (en) * | 2019-03-05 | 2020-09-18 | 김용현 | Drug mixing device, drug mixing kit comprising the same and method for manufacturing the same |
US11484470B2 (en) | 2019-04-30 | 2022-11-01 | West Pharma. Services IL, Ltd. | Liquid transfer device with dual lumen IV spike |
US11311458B2 (en) | 2019-09-11 | 2022-04-26 | B Braun Medical Inc. | Binary connector for drug reconstitution |
US11660255B1 (en) | 2019-12-23 | 2023-05-30 | Marco Navarro | Liquid medication dispenser |
US11590057B2 (en) | 2020-04-03 | 2023-02-28 | Icu Medical, Inc. | Systems, methods, and components for transferring medical fluids |
US11340104B2 (en) * | 2020-07-07 | 2022-05-24 | Matthew Moers | Syringe with a valve in a housing for measuring chemicals |
USD956958S1 (en) | 2020-07-13 | 2022-07-05 | West Pharma. Services IL, Ltd. | Liquid transfer device |
CA3198353A1 (en) | 2020-10-09 | 2022-04-14 | Icu Medical, Inc. | Fluid transfer device and method of use for same |
USD1010112S1 (en) | 2021-07-03 | 2024-01-02 | KAIRISH INNOTECH Private Ltd. | Vial adapter with valve |
USD983366S1 (en) | 2021-07-15 | 2023-04-11 | Kairish Innotech Private Limited | Vial adapter |
Family Cites Families (241)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US62333A (en) * | 1867-02-26 | Henry holl | ||
US3059643A (en) * | 1954-12-10 | 1962-10-23 | Baxter Laboratories Inc | Pumping apparatus |
US2931668A (en) * | 1956-04-30 | 1960-04-05 | Bastian Blessing Co | Coupling |
US2968497A (en) * | 1958-02-05 | 1961-01-17 | Avro Aircraft Ltd | Self-sealing coupling |
DE1945279U (en) | 1966-07-02 | 1966-09-01 | Gruenenthal Chemie | AUXILIARY DEVICE FOR THE PRODUCTION OF STERILE SOLUTIONS. |
US3757981A (en) | 1969-11-24 | 1973-09-11 | Harris R | Valves and valve needle syringes |
US3618637A (en) * | 1970-02-04 | 1971-11-09 | Deseret Pharma | Rotary mixing valve |
US3826261A (en) | 1971-12-27 | 1974-07-30 | Upjohn Co | Vial and syringe assembly |
US4109670A (en) * | 1973-05-16 | 1978-08-29 | Slagel Roger D | Combination check flow control and selector valve |
US3885607A (en) | 1973-11-16 | 1975-05-27 | Richard I Peltier | Device for providing fluid communication between two sealed vessels |
US3977555A (en) | 1974-05-07 | 1976-08-31 | Pharmaco, Inc. | Protective safety cap for medicament vial |
US3957052A (en) * | 1974-09-13 | 1976-05-18 | Medical Development Corporation | Pumping-syringe |
US3993063A (en) | 1975-06-16 | 1976-11-23 | Union Carbide Corporation | Protective shielding assembly for use in loading a hypodermic syringe with radioactive material |
US4051852A (en) * | 1975-06-26 | 1977-10-04 | The Kendall Company | Aspirating device |
US4020839A (en) * | 1976-02-26 | 1977-05-03 | Parke, Davis & Company | Medicament-dispensing package |
US4210173A (en) * | 1976-12-06 | 1980-07-01 | American Hospital Supply Corporation | Syringe pumping system with valves |
US4187848A (en) * | 1977-07-18 | 1980-02-12 | The Kendall Company | Adapter assembly |
USD257286S (en) * | 1978-03-06 | 1980-10-07 | Tronomed International, Inc. | Medical valve |
US4639019A (en) | 1979-06-04 | 1987-01-27 | Baxter Travenol Laboratories, Inc. | Luer connection |
US4253501A (en) | 1979-11-09 | 1981-03-03 | Ims Limited | Transfer system |
USD267199S (en) * | 1980-07-17 | 1982-12-07 | Abbott Laboratories | Vial and solution container connecting device |
USD271421S (en) * | 1981-06-12 | 1983-11-15 | Fetterman James W | Medical valve |
US4493348A (en) * | 1981-06-29 | 1985-01-15 | Pur/Acc Corporation | Method and apparatus for orally dispensing liquid medication |
US4434823A (en) | 1981-06-29 | 1984-03-06 | American Hospital Supply Corporation | Liquid transfer device |
US4475915A (en) * | 1982-05-07 | 1984-10-09 | Sloane Glenn L | Holder for a syringe and an ampoule |
US4588396A (en) | 1982-10-22 | 1986-05-13 | Stroebel Maurice G | Apparatus for gravity feed of liquid under constant hydrostatic pressure |
USD280018S (en) * | 1982-10-25 | 1985-08-06 | Commonwealth Industries | Syringe loading guide |
CA1215945A (en) * | 1983-03-20 | 1986-12-30 | Bengt Gustavsson | Fluid transfer system |
US4676530A (en) * | 1983-04-07 | 1987-06-30 | Warner-Lambert Company | Coupling assembly for use in fluid flow systems |
US4778447A (en) * | 1983-05-20 | 1988-10-18 | Travenol European Research & Development Center | Connectors |
JPS6026391U (en) * | 1983-07-30 | 1985-02-22 | 株式会社ハーマン | pipe fittings |
US4532969A (en) * | 1983-09-21 | 1985-08-06 | Kwaan Hau C | Fluid withdrawal and instillation device |
IT1173370B (en) * | 1984-02-24 | 1987-06-24 | Erba Farmitalia | SAFETY DEVICE TO CONNECT A SYRINGE TO THE MOUTH OF A BOTTLE CONTAINING A DRUG OR A TUBE FOR DISPENSING THE SYRINGE DRUG |
US5088996A (en) | 1984-04-16 | 1992-02-18 | Kopfer Rudolph J | Anti-aerosoling drug reconstitution device |
US4697622A (en) | 1984-06-01 | 1987-10-06 | Parker Hannifin Corporation | Passive filling device |
US4588403A (en) * | 1984-06-01 | 1986-05-13 | American Hospital Supply Corporation | Vented syringe adapter assembly |
US4604093A (en) * | 1984-06-12 | 1986-08-05 | I-Flow Corporation | Apparatus and method for administering multiple fluid infusions |
US5113904A (en) | 1984-07-13 | 1992-05-19 | Aslanian Jerry L | Flow control device for administration of intravenous fluids |
US4607671A (en) | 1984-08-21 | 1986-08-26 | Baxter Travenol Laboratories, Inc. | Reconstitution device |
US4759756A (en) * | 1984-09-14 | 1988-07-26 | Baxter Travenol Laboratories, Inc. | Reconstitution device |
US4614437A (en) | 1984-11-02 | 1986-09-30 | Dougherty Brothers Company | Mixing container and adapter |
US4721133A (en) * | 1985-09-26 | 1988-01-26 | Alcon Laboratories, Inc. | Multiple use valving device |
US4667927A (en) * | 1985-11-08 | 1987-05-26 | Rao Medical Devices, Inc. | Liquid flow metering device |
US4865592A (en) * | 1986-02-20 | 1989-09-12 | Becton, Dickinson And Company | Container and needle assembly |
US4834152A (en) * | 1986-02-27 | 1989-05-30 | Intelligent Medicine, Inc. | Storage receptacle sealing and transfer apparatus |
US5049129A (en) | 1986-05-29 | 1991-09-17 | Zdeb Brian D | Adapter for passive drug delivery system |
SE461765B (en) * | 1986-07-10 | 1990-03-26 | Haessle Ab | DEVICE FOR RELEASE OF SUBSTANCE |
IT1201801B (en) | 1986-08-04 | 1989-02-02 | Pietro Cosmai | MIXER LOADER FOR TRANSCUTANEOUS INJECTORS |
US4743229A (en) | 1986-09-29 | 1988-05-10 | Collagen Corporation | Collagen/mineral mixing device and method |
US4729401A (en) * | 1987-01-29 | 1988-03-08 | Burron Medical Inc. | Aspiration assembly having dual co-axial check valves |
US4787898A (en) | 1987-05-12 | 1988-11-29 | Burron Medical Inc. | Vented needle with sideport |
US4758235A (en) * | 1987-05-26 | 1988-07-19 | Tu Ho C | Cardiopulmonary resuscitation medication assembly |
US5178607A (en) | 1987-07-31 | 1993-01-12 | Lynn Lawrence A | Blood aspiration assembly septum and blunt needle aspirator |
IT211830Z2 (en) * | 1987-09-22 | 1989-05-25 | Farmitalia Carl Erba S P A | SAFETY DEVICE FOR THE INTRODUCTION AND WITHDRAWAL OF LIQUIDS IN AND FROM DRUG BOTTLES AND SIMILAR. |
USD314050S (en) * | 1987-11-27 | 1991-01-22 | Terumo Kabushiki Kaisha | Medical connector |
GB2214002B (en) * | 1987-12-15 | 1992-02-19 | Bicc Plc | Electrical connector |
US5211638A (en) | 1988-01-25 | 1993-05-18 | Baxter International Inc. | Pre-slit injection site |
DE3804429A1 (en) * | 1988-02-12 | 1989-08-24 | Schleicher & Schuell Gmbh | DISPOSABLE FILTER |
US6344031B1 (en) | 1989-03-22 | 2002-02-05 | Laurel A. Novacek | Safety syringe needle device with interchangeable and retractable needle platform |
US5122124A (en) * | 1988-12-14 | 1992-06-16 | Patco Ventures Ltd. | Safety syringe needle device with interchangeable and retractable needle platform |
US5035686A (en) * | 1989-01-27 | 1991-07-30 | C. R. Bard, Inc. | Catheter exchange system with detachable luer fitting |
US5135492A (en) | 1989-06-26 | 1992-08-04 | University Of Florida | Arterial/venous fluid transfer system |
US4967797A (en) * | 1989-08-16 | 1990-11-06 | Manska Wayne E | Tap valve |
US5053015A (en) * | 1989-08-30 | 1991-10-01 | The Kendall Company | Locking catheter adapter |
US4997430A (en) * | 1989-09-06 | 1991-03-05 | Npbi Nederlands Produktielaboratorium Voor Bloedtransfusieapparatuur En Infusievloeistoffen B.V. | Method of and apparatus for administering medicament to a patient |
USRE38996E1 (en) | 1990-04-20 | 2006-02-28 | Becton, Dickinson And Company | Needle tip cover |
US5104387A (en) * | 1990-05-25 | 1992-04-14 | St. Jude Medical, Inc. | Bi-planar fluid control valve |
US5045066A (en) * | 1990-06-07 | 1991-09-03 | Smith & Nephew, Inc. | Dental needle with stick resistant protective sleeve |
US5203775A (en) | 1990-09-18 | 1993-04-20 | Medex, Inc. | Needleless connector sample site |
US5125908A (en) * | 1990-10-19 | 1992-06-30 | Cohen Milton J | Hypodermic syringe with protective holder |
US5201717A (en) * | 1990-12-05 | 1993-04-13 | Philip Wyatt | Safety enclosure |
JP3066611B2 (en) | 1991-04-30 | 2000-07-17 | 武田薬品工業株式会社 | Aseptic holding and mixing device for two drugs housed in individually sealed containers |
US5183469A (en) | 1991-05-10 | 1993-02-02 | Becton, Dickinson And Company | Device for the removal and replacement of a needle shield |
DE4122221A1 (en) | 1991-07-04 | 1993-03-18 | Axel Von Brand | TRANSFER AND REMOVAL SPIKE |
DE4122476A1 (en) | 1991-07-06 | 1993-01-07 | Leopold Pharma Gmbh | Sterile liq. transfer in e.g. medical infusion mixts. - using double, self sealing, spined cannula coupling |
US5288290A (en) * | 1991-09-25 | 1994-02-22 | Alcon Surgical, Inc. | Multi-ported valve assembly |
WO1993010001A1 (en) * | 1991-11-21 | 1993-05-27 | Gds Technology, Inc. | Fluid transfer device |
US5171230A (en) * | 1991-11-29 | 1992-12-15 | Medex, Inc. | Fast flush catheter valve |
US5247972A (en) * | 1991-12-17 | 1993-09-28 | Whittier Medical, Inc. | Alignment guide for hypodermic syringe |
US5279597A (en) | 1992-01-13 | 1994-01-18 | Arrow International Investment Corp. | Catheter compression clamp |
CA2093560C (en) | 1992-04-10 | 2005-06-07 | Minoru Honda | Fluid container |
US5328474A (en) | 1992-04-13 | 1994-07-12 | B. Braun Medical Inc. | Tamper resistant syringe cap |
JP2605345Y2 (en) | 1992-05-01 | 2000-07-10 | 株式会社大塚製薬工場 | Drug container |
JPH05317383A (en) * | 1992-05-19 | 1993-12-03 | Nissho Corp | Solution container equipped with means for communicating with chemical container |
US5279576A (en) | 1992-05-26 | 1994-01-18 | George Loo | Medication vial adapter |
GB9211912D0 (en) | 1992-06-04 | 1992-07-15 | Drg Flexpak Ltd | Vial connector system |
US5344417A (en) | 1992-09-11 | 1994-09-06 | Becton, Dickinson And Company | Universal fitting for inoculation receptacles |
US5334163A (en) * | 1992-09-16 | 1994-08-02 | Sinnett Kevin B | Apparatus for preparing and administering a dose of a fluid mixture for injection into body tissue |
US5385547A (en) | 1992-11-19 | 1995-01-31 | Baxter International Inc. | Adaptor for drug delivery |
US5269768A (en) | 1993-02-08 | 1993-12-14 | Smiths Industries Medical Systems, Inc. | Valved suction catheter |
US5312377A (en) | 1993-03-29 | 1994-05-17 | Dalton Michael J | Tapered luer connector |
US5591143A (en) | 1993-04-02 | 1997-01-07 | Medrad Inc. | Luer connector with torque indicator |
US5607439A (en) | 1993-06-24 | 1997-03-04 | Yoon; Inbae | Safety penetrating instrument with penetrating member moving during penetration and triggered safety member protrusion |
US5364387A (en) | 1993-08-02 | 1994-11-15 | Becton, Dickinson And Company | Drug access assembly for vials and ampules |
RU2141306C1 (en) | 1993-09-07 | 1999-11-20 | Дебиотек С.А. | Syringe device for mixing of two components |
SE9303178D0 (en) | 1993-09-29 | 1993-09-29 | Kabi Pharmacia Ab | Improvements in injection cartridges |
US5509433A (en) | 1993-10-13 | 1996-04-23 | Paradis; Joseph R. | Control of fluid flow |
US5466220A (en) * | 1994-03-08 | 1995-11-14 | Bioject, Inc. | Drug vial mixing and transfer device |
US5520659A (en) | 1994-03-09 | 1996-05-28 | Joseph K. Andonian | Syringe needle cover and vial connector |
US5462317A (en) | 1994-03-23 | 1995-10-31 | Keller; Wilhelm A. | Adapter for a mixing or dispensing device |
DE4414697C2 (en) | 1994-04-27 | 1998-06-18 | Caremed Vertriebsgesellschaft | Device for transferring and removing liquids from bottles, bags or similar containers for medical purposes |
US5832971A (en) | 1994-05-19 | 1998-11-10 | Becton, Dickinson And Company | Syringe filling and delivery device |
US5746733A (en) | 1994-05-19 | 1998-05-05 | Becton, Dickinson And Company | Syringe filling and delivery device |
IL113832A (en) | 1994-05-23 | 1999-11-30 | Liposome Co Inc | Formulation preparation device |
US5649637A (en) | 1994-06-02 | 1997-07-22 | Automatic Liquid Packaging, Inc. | Torque-resistant closure for a hermetically sealed container |
US5470319A (en) | 1994-06-20 | 1995-11-28 | Critical Device Corporation | Needleless injection site |
EP0692235A1 (en) * | 1994-07-14 | 1996-01-17 | International Medication Systems (U.K.) Ltd. | Mixing & dispensing apparatus |
US5526853A (en) | 1994-08-17 | 1996-06-18 | Mcgaw, Inc. | Pressure-activated medication transfer system |
FR2726768A1 (en) | 1994-11-14 | 1996-05-15 | Debiotech Sa | SYRINGE DEVICE ATTACHABLE TO A VIAL |
US6681810B2 (en) | 1994-12-20 | 2004-01-27 | Aradigm Corporation | Filling device for a needleless injector cartridge |
US5531695A (en) | 1994-12-22 | 1996-07-02 | Sherwood Medical Company | Tamper evident sleeve |
US5653686A (en) | 1995-01-13 | 1997-08-05 | Coulter Corporation | Closed vial transfer method and system |
US5492147A (en) | 1995-01-17 | 1996-02-20 | Aeroquip Corporation | Dry break coupling |
US5647845A (en) | 1995-02-01 | 1997-07-15 | Habley Medical Technology Corporation | Generic intravenous infusion system |
US5674195A (en) | 1995-02-06 | 1997-10-07 | Truthan; Charles Edwin | Syringe apparatus and method of mixing liquid medicants within a syringe |
DE19504413A1 (en) | 1995-02-10 | 1996-08-22 | Pharmacia Gmbh | Transfer device |
US5584819A (en) | 1995-03-13 | 1996-12-17 | Kopfer; Rudolph J. | Nested blunt/sharp injection assembly |
IL114960A0 (en) | 1995-03-20 | 1995-12-08 | Medimop Medical Projects Ltd | Flow control device |
US5651776A (en) | 1995-03-22 | 1997-07-29 | Angiodynamics, Inc. | Luer-type connector |
US5566729A (en) | 1995-04-06 | 1996-10-22 | Abbott Laboratories | Drug reconstitution and administration system |
DE19513666C1 (en) | 1995-04-11 | 1996-11-28 | Behringwerke Ag | Device for bringing together a first liquid and a second solid or liquid component by means of negative pressure under sterile conditions |
US5839715A (en) | 1995-05-16 | 1998-11-24 | Alaris Medical Systems, Inc. | Medical adapter having needleless valve and sharpened cannula |
US5616203A (en) | 1995-07-14 | 1997-04-01 | Merit Medical | Method of manufacturing a split ring airless rotatable connector |
FR2738550B1 (en) * | 1995-09-11 | 1997-11-07 | Biodome | DEVICE FOR SEALING A CONTAINER ITSELF CLOSED, ASSEMBLY FOR PROVIDING A PRODUCT COMPRISING SUCH A CONTAINER AND SUCH A SEALING DEVICE |
US5611576A (en) | 1995-11-24 | 1997-03-18 | Industrie Borla Spa | Female coupling element for haemodialysis medical equipment |
US5833213A (en) | 1995-12-29 | 1998-11-10 | Rymed Technologies, Inc. | Multiple dose drug vial adapter for use with a vial having a pierceable septum and a needleless syringe |
US5893397A (en) | 1996-01-12 | 1999-04-13 | Bioject Inc. | Medication vial/syringe liquid-transfer apparatus |
US6629959B2 (en) | 1996-02-27 | 2003-10-07 | Injectimed, Inc. | Needle tip guard for percutaneous entry needles |
US5879337A (en) | 1997-02-27 | 1999-03-09 | Injectimed, Inc. | Needle tip guard for hypodermic needles |
USD393722S (en) | 1996-04-04 | 1998-04-21 | Icu Medical, Inc. | Locking blunt cannula |
DE19619026A1 (en) | 1996-05-10 | 1997-11-13 | Trinova Gmbh | Quick coupling |
US5738144A (en) | 1996-10-11 | 1998-04-14 | Aeroquip Corporation | Luer connecting coupling |
US5772652A (en) | 1997-05-14 | 1998-06-30 | Comar, Inc. | Stab cap for a vial having a puncturable seal |
US5755696A (en) | 1997-06-30 | 1998-05-26 | Becton, Dickinson And Company | Syringe filling and delivery device |
US5820621A (en) | 1997-07-29 | 1998-10-13 | Becton, Dickinson And Company | Medical fluid transfer and delivery device |
IL121605A (en) | 1997-08-22 | 2001-03-19 | Medimop Medical Projects Ltd | Fluid access assembly and a method for preparing a liquid drug |
US5919182A (en) | 1997-09-12 | 1999-07-06 | Becton, Dickinson And Company | Medical fluid transfer and delivery device |
US5944700A (en) | 1997-09-26 | 1999-08-31 | Becton, Dickinson And Company | Adjustable injection length pen needle |
IT236233Y1 (en) | 1997-11-26 | 2000-08-08 | Eurospital S P A | DEVICE FOR THE CONNECTION OF A PHARMACEUTICAL PRODUCT CONTAINER TO A BAG OF LIQUID PRODUCT TO CARRY OUT THE |
US6159192A (en) | 1997-12-04 | 2000-12-12 | Fowles; Thomas A. | Sliding reconstitution device with seal |
US6457488B2 (en) | 1998-01-08 | 2002-10-01 | George Loo | Stopcock having axial port for syringe twist actuation |
FR2773735B1 (en) | 1998-01-20 | 2000-02-25 | Becton Dickinson France | WATERPROOF CONTAINMENT DEVICE |
US6681946B1 (en) | 1998-02-26 | 2004-01-27 | Becton, Dickinson And Company | Resealable medical transfer set |
US6003566A (en) | 1998-02-26 | 1999-12-21 | Becton Dickinson And Company | Vial transferset and method |
US6080132A (en) | 1998-02-27 | 2000-06-27 | Abbott Laboratories | Apparatus for altering characteristics of a fluid |
US6245044B1 (en) | 1998-07-17 | 2001-06-12 | Becton, Dickinson And Company | Variable extension combined spinal/epidural needle set and method for its use |
US6358236B1 (en) | 1998-08-06 | 2002-03-19 | Baxter International Inc. | Device for reconstituting medicaments for injection |
GB2359754B (en) | 2000-03-03 | 2004-04-28 | Nmt Group Plc | Needle sheath |
US20050137566A1 (en) | 2003-12-23 | 2005-06-23 | Fowles Thomas A. | Sliding reconstitution device for a diluent container |
AR021220A1 (en) | 1998-09-15 | 2002-07-03 | Baxter Int | CONNECTION DEVICE FOR ESTABLISHING A FLUID COMMUNICATION BETWEEN A FIRST CONTAINER AND A SECOND CONTAINER. |
US6113583A (en) | 1998-09-15 | 2000-09-05 | Baxter International Inc. | Vial connecting device for a sliding reconstitution device for a diluent container |
US7074216B2 (en) | 1998-09-15 | 2006-07-11 | Baxter International Inc. | Sliding reconstitution device for a diluent container |
USD427308S (en) * | 1999-01-22 | 2000-06-27 | Medimop Medical Projects Ltd. | Vial adapter |
FR2789369B1 (en) | 1999-02-10 | 2001-04-27 | Biodome | CONNECTION DEVICE BETWEEN A CONTAINER AND A CONTAINER AND READY-TO-USE ASSEMBLY COMPRISING SUCH A DEVICE |
US6099511A (en) | 1999-03-19 | 2000-08-08 | Merit Medical Systems, Inc. | Manifold with check valve positioned within manifold body |
US6231552B1 (en) | 1999-05-04 | 2001-05-15 | Saf-T-Med, Inc. | Threaded latching mechanism |
US6156025A (en) | 1999-06-17 | 2000-12-05 | Bracco Research Usa Inc. | Twist valve |
JP4236842B2 (en) | 1999-10-22 | 2009-03-11 | アンタレス・ファーマ・インコーポレーテッド | Medical syringe and drug loading system used therewith |
US6503240B1 (en) | 2000-01-24 | 2003-01-07 | Brocco Diagnostics, Inc. | Vial access adapter |
US6832994B2 (en) | 2000-01-24 | 2004-12-21 | Bracco Diagnostics Inc. | Table top drug dispensing vial access adapter |
USD445501S1 (en) | 2000-01-24 | 2001-07-24 | Bracco Diagnostics, Inc. | Vial access adapter |
US6544246B1 (en) | 2000-01-24 | 2003-04-08 | Bracco Diagnostics, Inc. | Vial access adapter and vial combination |
US7799009B2 (en) | 2000-01-24 | 2010-09-21 | Bracco Diagnostics Inc. | Tabletop drug dispensing vial access adapter |
US6139534A (en) * | 2000-01-24 | 2000-10-31 | Bracco Diagnostics, Inc. | Vial access adapter |
JP4372310B2 (en) * | 2000-04-10 | 2009-11-25 | ニプロ株式会社 | Adapter for mixed injection |
US6343629B1 (en) | 2000-06-02 | 2002-02-05 | Carmel Pharma Ab | Coupling device for coupling a vial connector to a drug vial |
JP5058425B2 (en) | 2000-08-02 | 2012-10-24 | ベクトン・ディキンソン・アンド・カンパニー | Pen needle and safety shield system |
JP2002177392A (en) | 2000-11-08 | 2002-06-25 | West Pharmaceutical Services Inc | Safety device of syringe |
US6666852B2 (en) | 2000-12-04 | 2003-12-23 | Bracco Diagnostics, Inc. | Axially activated vial access adapter |
US6558365B2 (en) | 2001-01-03 | 2003-05-06 | Medimop Medical Projects, Ltd. | Fluid transfer device |
USD468015S1 (en) | 2001-01-22 | 2002-12-31 | Astra Tech Ab | Combined connector with valve and non-return valve for medical equipment |
US6474375B2 (en) | 2001-02-02 | 2002-11-05 | Baxter International Inc. | Reconstitution device and method of use |
US6503244B2 (en) | 2001-03-07 | 2003-01-07 | Micro Therapeutics, Inc. | High pressure injection system |
US6656433B2 (en) | 2001-03-07 | 2003-12-02 | Churchill Medical Systems, Inc. | Vial access device for use with various size drug vials |
US6581593B1 (en) | 2001-04-03 | 2003-06-24 | Darren A. Rubin | Universal oxygen connector system |
US6745998B2 (en) | 2001-08-10 | 2004-06-08 | Alaris Medical Systems, Inc. | Valved male luer |
FR2829691B1 (en) | 2001-09-17 | 2004-07-09 | Sedat | DEVICE FOR BIDIRECTIONAL TRANSFER OF A LIQUID BETWEEN A BOTTLE AND A CARPULE |
US6715520B2 (en) | 2001-10-11 | 2004-04-06 | Carmel Pharma Ab | Method and assembly for fluid transfer |
CA2467066C (en) | 2001-11-14 | 2008-08-12 | Jms Co., Ltd. | Three-way stopcock, and liquid transfusion tubing set or blood transfusion tubing set using the three-way stopcock |
EP1557191B2 (en) | 2001-11-30 | 2016-09-07 | Novo Nordisk A/S | A safety needle assembly |
ES2605734T3 (en) | 2001-12-13 | 2017-03-16 | Becton, Dickinson And Company | Needle closure system extractor |
US6875205B2 (en) | 2002-02-08 | 2005-04-05 | Alaris Medical Systems, Inc. | Vial adapter having a needle-free valve for use with vial closures of different sizes |
US7867215B2 (en) | 2002-04-17 | 2011-01-11 | Carmel Pharma Ab | Method and device for fluid transfer in an infusion system |
USD472316S1 (en) | 2002-04-30 | 2003-03-25 | Sterling Medivations, Inc. | Pen needle catheter connector |
USD472630S1 (en) | 2002-04-30 | 2003-04-01 | Sterling Medivations, Inc. | Pen needle catheter connector |
USD476733S1 (en) | 2002-05-09 | 2003-07-01 | Becton, Dickinson And Company | Medical needle assembly |
JP4427965B2 (en) | 2002-07-02 | 2010-03-10 | ニプロ株式会社 | Chemical container with communication means |
JP4209642B2 (en) | 2002-07-26 | 2009-01-14 | 川澄化学工業株式会社 | Needle cover and needle cover with cap and needle with wing with needle cover |
JP2004097253A (en) | 2002-09-04 | 2004-04-02 | Nipro Corp | Liquid transfusion device |
US20040073189A1 (en) | 2002-10-09 | 2004-04-15 | Phil Wyatt | Vial access transfer set |
USD483869S1 (en) | 2002-10-29 | 2003-12-16 | Pre Holding, Inc. | Tubing connector |
US20060155257A1 (en) | 2002-11-08 | 2006-07-13 | Reynolds David L | Pharmaceutical delivery systems and methods for using same |
JP4341239B2 (en) | 2002-12-19 | 2009-10-07 | ニプロ株式会社 | Liquid transfer tool |
USD483487S1 (en) | 2002-12-19 | 2003-12-09 | Becton Dickinson And Company | Stopcock device |
ES2397833T3 (en) | 2003-03-05 | 2013-03-11 | Csl Behring Gmbh | Transfer device |
DE502004005171D1 (en) | 2003-03-06 | 2007-11-22 | Csl Behring Gmbh | Transfer device, in particular for medical fluids |
US20040181192A1 (en) | 2003-03-11 | 2004-09-16 | Cuppy Michael John | Vascular access device and method of using same |
US7024968B2 (en) | 2003-03-26 | 2006-04-11 | Boston Scientific Scimed, Inc. | Luer lock wrench |
US7001369B2 (en) | 2003-03-27 | 2006-02-21 | Scimed Life Systems, Inc. | Medical device |
US7040598B2 (en) | 2003-05-14 | 2006-05-09 | Cardinal Health 303, Inc. | Self-sealing male connector |
USD495416S1 (en) | 2003-05-30 | 2004-08-31 | Alaris Medical Systems, Inc. | Vial access device |
JP3883527B2 (en) | 2003-07-17 | 2007-02-21 | ニプロ株式会社 | Transfer needle |
FR2858931B1 (en) | 2003-08-21 | 2007-04-13 | Becton Dickinson France | DEVICE FOR ORAL ADMINISTRATION OF A MEDICINAL PRODUCT |
US7722090B2 (en) | 2004-03-26 | 2010-05-25 | Cook Incorporated | Method and apparatus for an improved luer fitting connection |
IL161660A0 (en) | 2004-04-29 | 2004-09-27 | Medimop Medical Projects Ltd | Liquid drug delivery device |
DE202004012714U1 (en) | 2004-08-12 | 2004-11-04 | Smiths Medical Deutschland Gmbh | Luer lock connector for medical devices |
EP2808586B1 (en) | 2004-09-03 | 2019-05-22 | Elcam Medical Agricultural Cooperative Association Ltd. | Stopcock |
US7731678B2 (en) | 2004-10-13 | 2010-06-08 | Hyprotek, Inc. | Syringe devices and methods for mixing and administering medication |
US7771383B2 (en) | 2004-10-22 | 2010-08-10 | Medegen, Inc. | Fluid control device with valve and methods of use |
US7523967B2 (en) | 2004-12-13 | 2009-04-28 | Alcon, Inc. | Tubing fitting |
US20060135948A1 (en) | 2004-12-16 | 2006-06-22 | Medtronic Vascular, Inc., A Delaware Corporation | Multi-exchange catheter guide member with improved seal |
ES2354018T3 (en) | 2005-02-14 | 2011-03-09 | Medimop Medical Projects Ltd. | MEDICAL DEVICE FOR THE IN SITU RECONSTITUTION OF LIQUID DRUGS IN MEDICINAL CONTAINERS. |
US20070060904A1 (en) | 2005-03-14 | 2007-03-15 | Becton, Dickinson And Company | Filling system and method for syringes with short needles |
US20060253084A1 (en) | 2005-05-03 | 2006-11-09 | Greg Nordgren | Outdwelling slit valves and assemblies for medical liquid flow through a cannula and related methods |
US20070088292A1 (en) | 2005-07-06 | 2007-04-19 | Fangrow Thomas F Jr | Medical connector with closeable male luer |
WO2007015233A1 (en) | 2005-08-01 | 2007-02-08 | Medimop Medical Projects Ltd | Liquid drug delivery system |
DK1919432T3 (en) | 2005-08-11 | 2012-01-30 | Medimop Medical Projects Ltd | Liquid Medication Transfer Devices for Safe Safe Resting Connection on Medical Vials |
US7882863B2 (en) | 2005-10-19 | 2011-02-08 | Cd Solutions, Llc | Apparatus and method for mixing and transferring medications |
US7611502B2 (en) | 2005-10-20 | 2009-11-03 | Covidien Ag | Connector for enteral fluid delivery set |
EP1951344B1 (en) | 2005-11-07 | 2014-05-28 | Industrie Borla SpA | Vented safe handling vial adapter |
JP2007143813A (en) | 2005-11-28 | 2007-06-14 | Nippon Sherwood Medical Industries Ltd | Medical stopcock |
US20070191767A1 (en) | 2005-12-16 | 2007-08-16 | Medtronic Vascular, Inc. | Bifurcated Catheter Joints |
ATE447923T1 (en) | 2006-02-16 | 2009-11-15 | Hoffmann La Roche | SYSTEM AND DEVICE FOR EXTRACTING PHARMACEUTICALS |
IL174352A0 (en) | 2006-03-16 | 2006-08-20 | Medimop Medical Projects Ltd | Medical devices for use with carpules |
JP4769103B2 (en) | 2006-03-17 | 2011-09-07 | 日本シャーウッド株式会社 | connector |
US7547300B2 (en) | 2006-04-12 | 2009-06-16 | Icu Medical, Inc. | Vial adaptor for regulating pressure |
JP4820703B2 (en) | 2006-04-28 | 2011-11-24 | 日本シャーウッド株式会社 | Liquid infusion tool |
JP2008005974A (en) | 2006-06-28 | 2008-01-17 | Nippon Sherwood Medical Industries Ltd | Lure fixing, fitting and connecting structure |
USD561348S1 (en) | 2006-08-17 | 2008-02-05 | Medimop Medical Projects Ltd. | Vial adapter |
US8167863B2 (en) | 2006-10-16 | 2012-05-01 | Carefusion 303, Inc. | Vented vial adapter with filter for aerosol retention |
US7758082B2 (en) | 2006-12-05 | 2010-07-20 | Nxstage Medical, Inc. | Fluid line connector safety device |
IL182922A0 (en) | 2007-05-02 | 2007-09-20 | Medimop Medical Projects Ltd | Automatic liquid drug reconstitution apparatus |
IL186290A0 (en) | 2007-09-25 | 2008-01-20 | Medimop Medical Projects Ltd | Liquid drug delivery devices for use with syringe having widened distal tip |
US8287496B2 (en) | 2008-01-17 | 2012-10-16 | Custom Medical Applications, Inc. | Flow elements for use with flexible spinal needles, needle assemblies and methods therefor |
IL188975A0 (en) | 2008-01-23 | 2008-11-03 | Medimop Medical Projects Ltd | Fluid control device with stopper |
US7967785B2 (en) | 2008-07-14 | 2011-06-28 | Nipro Healthcare Systems, Llc | Insulin reservoir detection via magnetic switching |
USD595420S1 (en) | 2008-07-18 | 2009-06-30 | Hitachi High-Technologies Corporation | Adapter for a sample rack |
USD595862S1 (en) | 2008-07-18 | 2009-07-07 | Hitachi High-Technologies Corporation | Adapter for a sample rack |
USD595863S1 (en) | 2008-07-18 | 2009-07-07 | Hitachi High-Technologies Corporation | Adapter for a sample rack |
USD595421S1 (en) | 2008-07-18 | 2009-06-30 | Hitachi High-Technologies Corporation | Adapter for a sample rack |
USD616984S1 (en) | 2009-07-02 | 2010-06-01 | Medimop Medical Projects Ltd. | Vial adapter having side windows |
-
1995
- 1995-08-16 IL IL11496095A patent/IL114960A0/en unknown
-
1996
- 1996-03-18 IL IL11752596A patent/IL117525A/en not_active IP Right Cessation
- 1996-03-19 JP JP52856496A patent/JP3782453B2/en not_active Expired - Lifetime
- 1996-03-19 US US08/913,432 patent/US6238372B1/en not_active Expired - Lifetime
- 1996-03-19 CA CA 2215752 patent/CA2215752C/en not_active Expired - Lifetime
- 1996-03-19 AT AT96907937T patent/ATE202290T1/en not_active IP Right Cessation
- 1996-03-19 WO PCT/US1996/003732 patent/WO1996029113A1/en active IP Right Grant
- 1996-03-19 DE DE1996613461 patent/DE69613461T2/en not_active Expired - Lifetime
- 1996-03-19 EP EP19960907937 patent/EP0814866B1/en not_active Expired - Lifetime
- 1996-03-19 AU AU51366/96A patent/AU5136696A/en not_active Abandoned
-
2000
- 2000-08-08 US US09/633,056 patent/US6379340B1/en not_active Expired - Lifetime
-
2002
- 2002-01-31 US US10/062,796 patent/US7326194B2/en not_active Expired - Fee Related
-
2006
- 2006-11-13 US US11/559,152 patent/US7879018B2/en not_active Expired - Fee Related
-
2007
- 2007-03-30 US US11/694,297 patent/US7632261B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69613461T2 (en) | 2002-04-25 |
ATE202290T1 (en) | 2001-07-15 |
US20070088313A1 (en) | 2007-04-19 |
US20070270778A9 (en) | 2007-11-22 |
CA2215752A1 (en) | 1996-09-26 |
IL117525A0 (en) | 1996-07-23 |
IL117525A (en) | 2001-06-14 |
JPH11503627A (en) | 1999-03-30 |
AU5136696A (en) | 1996-10-08 |
JP3782453B2 (en) | 2006-06-07 |
DE69613461D1 (en) | 2001-07-26 |
US20070167904A1 (en) | 2007-07-19 |
US6379340B1 (en) | 2002-04-30 |
US7326194B2 (en) | 2008-02-05 |
US20020087144A1 (en) | 2002-07-04 |
US7879018B2 (en) | 2011-02-01 |
EP0814866A1 (en) | 1998-01-07 |
US6238372B1 (en) | 2001-05-29 |
US7632261B2 (en) | 2009-12-15 |
WO1996029113A1 (en) | 1996-09-26 |
EP0814866B1 (en) | 2001-06-20 |
IL114960A0 (en) | 1995-12-08 |
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