CA2187735A1 - Analyte detection from steady-state luminescence lifetime - Google Patents

Analyte detection from steady-state luminescence lifetime

Info

Publication number
CA2187735A1
CA2187735A1 CA002187735A CA2187735A CA2187735A1 CA 2187735 A1 CA2187735 A1 CA 2187735A1 CA 002187735 A CA002187735 A CA 002187735A CA 2187735 A CA2187735 A CA 2187735A CA 2187735 A1 CA2187735 A1 CA 2187735A1
Authority
CA
Canada
Prior art keywords
analyte
luminescence
phore
fluoro
employed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002187735A
Other languages
French (fr)
Other versions
CA2187735C (en
Inventor
Ralph Zuckerman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2187735A1 publication Critical patent/CA2187735A1/en
Application granted granted Critical
Publication of CA2187735C publication Critical patent/CA2187735C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14555—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted for the eye fundus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6445—Measuring fluorescence polarisation

Abstract

Methods and apparatus determine analyte concentradon in vivo and in vitro by the steady state determination of luminescence lifetime. A fluoro-phore that is quenched by the analyte is free to undergo Brownian rotation. The fluoro-phore (12) is irradiated with continuous linearly polarized light (24). Emitted luminescence is resolved into vector components parallel and perpendicular to the plane of polarization of the excitation light (36, 38). A mathematical function is employed which relates the luminescence anisotropy to quencher concentration. For analytes which do not quench excited staves, a known quantity of the analyte is conjugated to a quencher molecule or energy transfer acceptor, and a competition reaction is set up in which labelled and unlabelled analytes compete for sites on a labelled carrier molecule. An empirically determined mathematical function is employed which relates luminescence anisotropy at the carrier label emission band to analyte concentration.
CA002187735A 1994-04-21 1995-04-19 Analyte detection from steady-state luminescence lifetime Expired - Lifetime CA2187735C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/231,191 US5515864A (en) 1994-04-21 1994-04-21 Method and apparatus for the in vivo measurement of oxygen concentration levels by the indirect determination of fluoescence lifetime
US08/231,191 1994-04-21
PCT/US1995/004772 WO1995028875A1 (en) 1994-04-21 1995-04-19 Analyte detection from steady-state luminescence lifetime

Publications (2)

Publication Number Publication Date
CA2187735A1 true CA2187735A1 (en) 1995-11-02
CA2187735C CA2187735C (en) 2007-09-04

Family

ID=22868121

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002187735A Expired - Lifetime CA2187735C (en) 1994-04-21 1995-04-19 Analyte detection from steady-state luminescence lifetime

Country Status (9)

Country Link
US (3) US5515864A (en)
EP (1) EP0758212B1 (en)
JP (1) JP3579424B2 (en)
CN (1) CN1150749A (en)
AT (1) ATE296052T1 (en)
AU (1) AU691285B2 (en)
CA (1) CA2187735C (en)
DE (1) DE69534228T2 (en)
WO (1) WO1995028875A1 (en)

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Also Published As

Publication number Publication date
US5495850A (en) 1996-03-05
CN1150749A (en) 1997-05-28
US5626134A (en) 1997-05-06
DE69534228T2 (en) 2006-03-16
EP0758212B1 (en) 2005-05-25
DE69534228D1 (en) 2005-06-30
JP3579424B2 (en) 2004-10-20
EP0758212A1 (en) 1997-02-19
WO1995028875A1 (en) 1995-11-02
JPH09512446A (en) 1997-12-16
AU691285B2 (en) 1998-05-14
AU2424595A (en) 1995-11-16
US5515864A (en) 1996-05-14
ATE296052T1 (en) 2005-06-15
CA2187735C (en) 2007-09-04
EP0758212A4 (en) 1998-07-15

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