CA2186493C - A dilation-drug delivery catheter - Google Patents
A dilation-drug delivery catheter Download PDFInfo
- Publication number
- CA2186493C CA2186493C CA002186493A CA2186493A CA2186493C CA 2186493 C CA2186493 C CA 2186493C CA 002186493 A CA002186493 A CA 002186493A CA 2186493 A CA2186493 A CA 2186493A CA 2186493 C CA2186493 C CA 2186493C
- Authority
- CA
- Canada
- Prior art keywords
- drug delivery
- dilation
- lumen
- catheter
- catheter shaft
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/104—Balloon catheters used for angioplasty
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M2025/0175—Introducing, guiding, advancing, emplacing or holding catheters having telescopic features, interengaging nestable members movable in relations to one another
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1011—Multiple balloon catheters
- A61M2025/1015—Multiple balloon catheters having two or more independently movable balloons where the distance between the balloons can be adjusted, e.g. two balloon catheters concentric to each other forming an adjustable multiple balloon catheter system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1052—Balloon catheters with special features or adapted for special applications for temporarily occluding a vessel for isolating a sector
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1079—Balloon catheters with special features or adapted for special applications having radio-opaque markers in the region of the balloon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1006—Balloons formed between concentric tubes
Abstract
A dilation-drug delivery catheter (10) comprises a dilation portion (20) for dilating a stenosis and a drug delivery portion (50) for delivering antithrombolytic or antiproliferative, or any other type of medication, to the dilation site. The drug delivery portion (50) of the catheter (10) is located within the dilation portion (20), which can be retracted to reveal the drug delivery portion (50), after dilation.
Occlusion balloons (58, 60) are preferably provided on the drug delivery portion (50) to isolate the dilation site during drug delivery.
Occlusion balloons (58, 60) are preferably provided on the drug delivery portion (50) to isolate the dilation site during drug delivery.
Description
A DILATION-DRUG DELIVERY CATHETER
FIELD OF THE INVENTION
A dilation-drug delivery catheter, and, more particularly, a dilation-drug delivery catheter comprising a drug delivery portion within a dilation portion, wherein the dilation portion can be retracted after dilation, revealing the drug delivery portion.
BACKGROUND OF THE INVENTION
Percutaneous transluminal angioplasty ("PTA") and percutaneous transluminal coronary angioplasty ("PTCA"), wherein a dilation balloon is advanced through the vascular-system to a stenosis and , inflated to open the blockage, is now a commonplace procedure. In about one-third of the cases, however, the procedure leads to restenosis that can require another dilation procedure. It is estimated that the total cost of restenoais requiring an additional dilation procedure or some other treatment, is over
FIELD OF THE INVENTION
A dilation-drug delivery catheter, and, more particularly, a dilation-drug delivery catheter comprising a drug delivery portion within a dilation portion, wherein the dilation portion can be retracted after dilation, revealing the drug delivery portion.
BACKGROUND OF THE INVENTION
Percutaneous transluminal angioplasty ("PTA") and percutaneous transluminal coronary angioplasty ("PTCA"), wherein a dilation balloon is advanced through the vascular-system to a stenosis and , inflated to open the blockage, is now a commonplace procedure. In about one-third of the cases, however, the procedure leads to restenosis that can require another dilation procedure. It is estimated that the total cost of restenoais requiring an additional dilation procedure or some other treatment, is over
2 billion dollars per year worldwide.
Various agents that may reduce restenosis can be applied to the dilation site. For example, antithrombolytic agents such as heparin may prevent clotting. Antiproliferative agents, such as dexamethasone, can prevent smooth muscle cell migration and proliferation.
Various methods have been proposed to effectively deliver such agents to the dilation site.
For example, in U.S. Patent No. 5,087,244, to Wolinsky, a catheter is disclosed having a thin walled flexible balloon with a plurality of small holes. After an angioplastic procedure, such a balloon can be advanced to the dilation site and inflated with heparin,- or some other medication. The medication exits the inflated balloon, which is in contact with the arterial wall, through the holes. Such "weeping" balloons may damage the arterial wall, however. In addition, having to insert a second catheter for drug delivery after removal of the dilation catheter is cumbersome and time consuming. It can also be difficult to precisely locate the dilation site after the dilation catheter is removed.
It is, therefore advantageous to provide a catheter which can both dilate the stenosis and immediately thereafter deliver drugs directly to the dilation site. U.S. Patent Nos.
4,824,436 and 4,636,195, also to Wolinsky, disclose a catheter with a dilation balloon and a pair of occlusion balloons proximal and distal to the dilation balloon. A drug delivery conduit is provided between the distal occlusion balloon and the dilation balloon. After dilation of the stenosis, the dilation balloon is deflated, the occlusion balloons are inflated and a drug is delivered. Because of the presence of the dilation balloon, there is only a small region available for drug delivery. Drug delivery may, therefore, be slow and of too low volume to be effective.
SUMMARY OF THE INVENTION
The present invention provides a dilation-drug delivery catheter comprising: a dilation portion comprising an outer catheter shaft, a dilation balloon attached to the outer catheter shaft, the outer catheter shaft comprising a dilation lumen for providing inflation fluid to the dilation balloon and a central lumen; and a drug delivery portion located at least in part within the central lumen, the drug delivery portion comprising an inner catheter shaft having at least one drug delivery port and defining a drug delivery lumen for providing a drug to the drug delivery port, the drug delivery port being located in a portion of the inner catheter shaft lying within
Various agents that may reduce restenosis can be applied to the dilation site. For example, antithrombolytic agents such as heparin may prevent clotting. Antiproliferative agents, such as dexamethasone, can prevent smooth muscle cell migration and proliferation.
Various methods have been proposed to effectively deliver such agents to the dilation site.
For example, in U.S. Patent No. 5,087,244, to Wolinsky, a catheter is disclosed having a thin walled flexible balloon with a plurality of small holes. After an angioplastic procedure, such a balloon can be advanced to the dilation site and inflated with heparin,- or some other medication. The medication exits the inflated balloon, which is in contact with the arterial wall, through the holes. Such "weeping" balloons may damage the arterial wall, however. In addition, having to insert a second catheter for drug delivery after removal of the dilation catheter is cumbersome and time consuming. It can also be difficult to precisely locate the dilation site after the dilation catheter is removed.
It is, therefore advantageous to provide a catheter which can both dilate the stenosis and immediately thereafter deliver drugs directly to the dilation site. U.S. Patent Nos.
4,824,436 and 4,636,195, also to Wolinsky, disclose a catheter with a dilation balloon and a pair of occlusion balloons proximal and distal to the dilation balloon. A drug delivery conduit is provided between the distal occlusion balloon and the dilation balloon. After dilation of the stenosis, the dilation balloon is deflated, the occlusion balloons are inflated and a drug is delivered. Because of the presence of the dilation balloon, there is only a small region available for drug delivery. Drug delivery may, therefore, be slow and of too low volume to be effective.
SUMMARY OF THE INVENTION
The present invention provides a dilation-drug delivery catheter comprising: a dilation portion comprising an outer catheter shaft, a dilation balloon attached to the outer catheter shaft, the outer catheter shaft comprising a dilation lumen for providing inflation fluid to the dilation balloon and a central lumen; and a drug delivery portion located at least in part within the central lumen, the drug delivery portion comprising an inner catheter shaft having at least one drug delivery port and defining a drug delivery lumen for providing a drug to the drug delivery port, the drug delivery port being located in a portion of the inner catheter shaft lying within
3 the central lumen, wherein the dilation portion can move with respect to the drug delivery portion such that the dilation portion can be retracted from the distal end of the drug delivery portion, revealing the drug delivery port, the drug delivery portion further comprising: a first occlusion balloon distal to the drug delivery port; an inflation lumen in fluid communication with the first occlusion balloon; and a second occlusion balloon proximal to the drug delivery port; wherein the dilation portion can be retracted to reveal the first occlusion balloon.
The occlusion balloons maintain the delivered drug in proximity with the dilation site. The same inflation lumen can be in fluid communication with the first and second balloons.
A plurality of drug delivery ports are preferably provided, as are perfusion means for allowing blood to flow through the dilation-drug delivery catheter, beyond the occlusion balloon.
The invention also provides a dilation-drug delivery catheter comprising a dilation portion comprising a dilation balloon and a drug delivery portion having a distal end, wherein the portions can be moved with respect to each other, the catheter having a dilation position, wherein the distal end of the drug delivery portion is located at least in part within the dilation portion, and a drug delivery position, wherein the dilation portion is retracted to reveal the distal end of the drug delivery portion; and wherein the dilation portion further comprises a dilation lumen for providing dilation fluid to the dilation balloon and a central lumen, wherein the drug delivery portion is located at least in part, within the central lumen and wherein the drug delivery portion comprises a catheter shaft comprising an inflation lumen and a drug delivery lumen;
and the distal end of the drug delivery portion comprises a
The occlusion balloons maintain the delivered drug in proximity with the dilation site. The same inflation lumen can be in fluid communication with the first and second balloons.
A plurality of drug delivery ports are preferably provided, as are perfusion means for allowing blood to flow through the dilation-drug delivery catheter, beyond the occlusion balloon.
The invention also provides a dilation-drug delivery catheter comprising a dilation portion comprising a dilation balloon and a drug delivery portion having a distal end, wherein the portions can be moved with respect to each other, the catheter having a dilation position, wherein the distal end of the drug delivery portion is located at least in part within the dilation portion, and a drug delivery position, wherein the dilation portion is retracted to reveal the distal end of the drug delivery portion; and wherein the dilation portion further comprises a dilation lumen for providing dilation fluid to the dilation balloon and a central lumen, wherein the drug delivery portion is located at least in part, within the central lumen and wherein the drug delivery portion comprises a catheter shaft comprising an inflation lumen and a drug delivery lumen;
and the distal end of the drug delivery portion comprises a
4 pair of occlusion balloons in fluid communication with the inflation lumen and a plurality of drug delivery ports between the occlusion balloons, the drug delivery ports being in fluid communication with the drug delivery lumen, wherein, in the drug delivery position, the dilation portion is retracted to reveal the occlusion balloons and the drug delivery ports.
The invention further provides a dilation-drug delivery catheter comprising: an outer catheter shaft, a dilation balloon bonded to the catheter shaft, the catheter shaft having an outer wall and an inner wall defining a lumen for providing dilation fluid to the dilation balloon, the inner wall further defining a central lumen, an inner catheter shaft comprising a pair of occlusion balloons at its proximal end, a lumen in fluid communication with the occlusion balloons to provide inflation fluid to the occlusion balloons, a plurality of drug delivery ports between the occlusion balloons, a lumen in fluid communication with the drug delivery ports to provide drugs to the ports, and a guide wire lumen, wherein at least a portion of the distal end of the inner catheter shaft lies within the central lumen, and the outer catheter shaft can be moved with respect to the inner catheter shaft to reveal the distal end of the inner catheter shaft.
Preferably, the drug delivery ports lie within the central lumen prior to the outer catheter shaft being retracted.
DESCRIPTION OF THE DRAWINGS
FIG. 1 is a view of a dilation-drug delivery catheter in accordance with the present invention, wherein the distal portion of the catheter is shown enlarged and in cross-section, in the dilation position of the catheter;
W095/28196 ~ PCTl1895/00052 _5_ FIG. 2 is a cross-sectional view of the distal portion of the catheter of FIG. 1, wherein a dilation balloon is shown inflated;
FIG. 3 is a cross-sectional view of the distal portion of the catheter of FIG_ 1, along line AA of FIG.-1;
FIG. 4 is a cross-sectional view of the distal portion of the catheter of FIG. 1, with its dilation portion retracted, showing the drug delivery position of the catheter; and FIG. 5 is a side view of-the distal portion of the catheter of FIG. 1, wherein two occlusion balloons are inflated.
DESCRIPTION OF THE INVENTION
FIG. 1 is a view of a dilation-drug delivery catheter 10 in accordance withthe present invention, wherein the distal portion of the catheter 10 is shown enlarged and in cross-section. The dilation-drug delivery catheter 10 comprises a dilation portion 20 and a drug delivery portion 50. The dilation portion 20 comprises a dilation balloon 24 bonded to an outer catheter shaft 22 at sites 26 and 28. In FIGS. 1-2, the catheter 10 is shown in its dilation position. In FIG. 1, the dilation balloon 24 is deflated, while in FIG. 2, a cross-sectional view of the distal portion of the dilation-drug delivery catheter 10 of FIG. 1, the dilation balloon 24 is shown inflated.
The outer catheter shaft 22 has an outer wall 34 " 30 and an inner wall 36 which define a dilation lumen for providing dilation fluid to the dilation balloon 22. The inner wall 36 also defines a central lumen 40 for receiving the drug delivery portion 50. FIG.
3 is a cross-sectional view of the dilation-drug W0 95128196 PCf/IB95/00052 delivery catheter 10, through line A-A of FIG. 1,-showing the outer wall 34, inner wall 36, the dilation lumen 38 and the central lumen 40.
The drug delivery portion 50 of the catheter-10 comprises an inner catheter shaft-52, whose distal end is located at least in part within the second lumen 40. The inner catheter shaft 52 includes a-drug -delivery-lumen 54, which communicates with the exterior of the shaft 52 through drug delivery ports 56. -There are preferably between 2-20 circular or oval shaped ports 56 witha diameter or length, respectively, of between about 0.003-0.020 inches.-Three drug delivery ports 56 are provided in this embodiment-. A plurality of such ports are preferably I5 provided to ensure the delivery of adequate-drug to the dilation site. The drug delivery ports-56 preferably lie within the central lumen 40 during dilation. FIG. 3-shows that the drug delivery lumen 54 is preferably semi-circular.
Returning to FIGS- 1-2, a distal occlusion balloon 58 and a proximal occlusion. balloon 60 are-preferably provided to isolate the dilation site during drug delivery. The-occlusion balloons 58, 60 are shown inflated in the side view of Fig. 5. The occlusion balloons 58, 60 maintain the drug in proximity with the portion-of the arterial wall which has been dilated, improving the absorption and efficacy of the drug. An inflation lumen 62 in the inner catheter shaft 52 is provided to convey inflation fluid to the occlusion balloons 58, 60.
The inner-catheter shaft 52 also typically includes a guide wire lumen 64. The-inflation lumen 62 and guide wire lumen 64 are shown in cross-section in Fig. 3. The inflation lumen 62 is also preferably-W095/28196 ~ PCT/1895/00052 semi=circular and in the same radial plane as the drug delivery lumen 54. To deliver an adequate amount of drug in the time allowed, the drug delivery lumen 54 will generally need to be larger than the inflation lumen 62. In the embodiment illustrated, the portion of the inner catheter shaft 52 including the distal occlusion balloon 58 extends beyond the distal tip of the dilation portion 20 while the catheter is in its dilation position. The distal occlusion balloon 58 can lie within-the second lumen 40 in the dilation position, as well.
In FIGS. 4 and 5, the dilation-drug delivery catheter 10 of the present invention is shown in its drug delivery position. In FIG. 4, the dilation portion 20 is shown retracted to fully reveal the distal end of the drug delivery portion 50 of the catheter 10, which comprises the occlusion balloons 58, 60, and the drug delivery ports 56. FIG. 5 is a side view of the catheter 10, showing the occlusion balloons 58, 60, inflated as they would be immediately prior to and during drug delivery. The present invention enables a plurality of drug delivery ports 56 to be provided between the occlusion balloons 58, 60, better ensuring the delivery of an adequate quantity of drug. Perfusion openings 88 are preferably provided through the walls of the inner catheter shaft 52 to the guide wire lumen 64 as shown in FIG. 5, to provide a path for blood to flow beyond the occluded site.- There are preferably between 2-20 circular or oval perfusion openings 88 with a diameter or length, respectively, of between about 0.003-0.020 inches. Three perfusion openings 88 are provided in this embodiment.
-g-Returning to FIG. 1, the proximal end o~ the-catheter 10 includes a Y-adaptor 68 including a port 66; as is known--iri the art-: A tube (not shown) is connected tothe dilation lumen 38 of the outer -cathetez shaft 22 and-extends through the port 66.
The outer catheter shaft ends within the Y-adaptor 68, proximate the base of the port 66. A syringe can be used-to supply the dilation fluid through the port 66 into the dilation lumen-38, also as is known in the art. A Tuohy-BOrst adapter 70 is threaded-on--the central port of the Y-adaptor 68. The inner catheter shaft 52 extends through the Y-adaptor--68 and Tuohy-Borst adapter 7D. In-this-embodiment, three tubes 72, 74, and 76 are connected to the drug delivery lumen 54, inflation lumen 62 and guide wire-lumen 64, respectively, of-the innercatheter shaft52. Hubs 78 are connected to each tube. The guide wire can be inserted into the guide wire lumen 64, through tube 76. Syringes can also be used to supply inflation fluid for the occlusion balloons 58, 6D and any desired drug through tubes=74 and 72, respectively.
The outer diameter of the catheter 10 and the deflated dilation balloon 24 is preferably ho greater than about 0.042-0.050 inches, so that it can be used with a 7 or 8 French guiding catheter. To accommodate the-tubes 72, 74, 76, the portion of the inner catheter shaft 52 which extends out of the Tuohy-Borst adapter 68 flares to an outer diameter of-about 0.200 inches at about point 80. The tubes 72, 74, 76, are held together by a heat shrink tubing 82.
The distal end 84 of the-inner catheter shaft 52 preferably includes a resilient tip 96 which comprises a material softer than that of the inner catheter shaft 22. The tip 96 spreads or bends when WO 95128196 PCT/lB95/00052 it contacts body tissue, easing the catheter's passage through the vascular system and helping to avoid tissue damage. The tip 96 can be made of ultra -low density palyethylene 4603 from Dow Chemical Corporation, which has a melt flow rate at 190C
(ASTM D-1238) of 0.7-0.9 g/l0,min. and a density (ASTM D-792) of 0.9030-0.9070 g/cc. The tip 96 can also be a,nylon, such as PEBA 25D from EIf Atochem Deutschland GmbH, which has an ultimate tensile -strength (ASTM D-638) of 4950 psi min., an ultimate elongation (ASTM-638) of 640% min., a flexural modulus (ASTM D-790) of-2100 psi min., a Durometer (ASTM D-2240) of 25D t 4D, and a melting point (ASTM
D-3418) of 142-153C. The tip 96 can be connected 1~ to the inner_catheter shaft 22 by an adhesive or thermal bonding.
Radiopaque markers 86 of gold or tantalum, for example, are also preferably prbvided on the inner catheter shaft 52 within the occlusion balloons 58, 60;--and on the outercatheter shaft 22 within the dilation balloon 24, as shown, to assist in monitoring the positionof the catheter on a fluoroscope during a PTA or PTCA procedure, as is known in the art. The inner catheter shaft 52 and occlusion balloons 58, 60, are preferably coated with a lubricous material, such as silicone, acrylimide, or a hydrophilic polyurethane coating, to ease retraction of the dilation portion 20 after dilation.
The outer catheter shaft 22 and dilation balloon 24 can be similarly coated to ease its advance through a guiding catheter and a lesion, as is known in the art.
The inner and outer catheter shafts can be of any material suitable for catheters, such as linear R'0 95/28196 9 ~ PCT/IB95100052 low density or high density polyethylene, nylon, polyurethane polypropylene, silicone rubber, or -other non-thrombogenic materials. A linear low density polyethylene which can be used for the outer catheter shaft 22 is Dowlex 2038 from Dow Chemical Company, which hasa melt-flow rate at 190°C (ASTM-D-1238) of 0.85-1_15 g/10 min. and a density (ASTM D-792) of 0.9330-0.9370 g/cc. A high density polyethylene which can be used for the outer catheter shaft 22 is LB 8320-00 from Quantum Chemical Corporation, which has a melt flow rate at 190°C
(ASTM D-1238) of 0.20-0_36 g/10 min. and a density (D-1505) of-0.9566 gjcc min.
A nylon which can be used for the inner or outer catheter shafts 22, 52 is nylon 12, such as L21d1F
Veatamed from Huls America Inc., which-has a relative viscosity (ISO 307) of-2_05-2.22 and a water content (ASTM D-4019) of 0.10 maximum. Another nylon which can be used is PEBA 70D from Elf Atochem, which has an ultimate tensile strength (ASTM D-638)of 8300 psi min., an ultimate elongation (ASTM D-638) of 400%
min., a flexural modulus (ASTM D-790) of 67,000 psi min., a Durometer (D-2240) of fi9D ~ 4D and a melting point (ASTM D-3418) of-160°-180°C.
A high density polyethylene which can be used for the inner-catheter shaft 52 is LM6007 from Quantum Chemical Corporation, which has the following characteristics:
Ultimate Tensile Strength 4400 psi min.
(ASTM D-638) Ultimate Elongation % 600% min.
at break (ASTM D-638) Durometer D Scale 68 ~ 4.5 (ASTM D-2240) WO 95128196 ~ ~ PCT/1895/00052 Melt Flow Rate at 240°C 2160g 0.070 (REF) (ASTM D-1238) Flexural Modulus at Room Temperature 220,000 psi min.
(ASTM D-790, Procedure B) Vicat Softening Point °C. 125°C (REF) (ASTM D-1525) The outer catheter shaft 22 and inner catheter shaft 52 are extruded separately --To-form the flared portion of the inner catheter shaft 52, a bump extrusion process can be used, as is known in the art. After extrusion of the inner catheter shaft 52, the tubes 72, 74 and 76 are inserted into the shaft's wider portion and thermally bonded in place. An adhesive can be used, as well. A tube (not shown) is inserted and similarly bonded to the dilation lumen 38 of the outer catheter shaft 22. That tube extends through the port 66 of the Tuohy-Borst adaptor 70.
After formation of the inner catheter shaft 52, the perfusion openings 88 and drug delivery ports 56 are made. Passages through the shaft 52 to the inflation lumen 62 proximate the intended location of the occlusion balloons, are also made. The radiopaque markers 86 are added to the inner and outer catheter shafts, as well. All these procedures are known in the art.
The dilation balloon 24 can be of any type and size appropriate for PTA and PTCA procedures. For example, the balloon 22 can be of polyethylene, polyethylene terephthalate, nylon, polyurethane or any other material suitable for a dilation balloon. The balloon 24 can be compliant, non-compliant or semi-compliant. The dilation balloon 24 can be attached to the outer catheter shaft 22 through thermal bond-ing, including laser bonding or ultrasonic bonding, or with an adhesive, as is known in the art. An apparatus and process for laser bonding angioplasty balloon catheters is disclosed in U. S. Patent No. 5,267,959 which was filed on November 29, 1991 by the inventor of the present invention and is assigned to the assignee of the present invention. The balloon 22 is preferably of the same or compatible material as the catheter shaft 28 to enable thermal bonding.
A low density polyethylene which can be used for the dilation balloon 24 is P. E. 1031 from Rexene Corporation, which has a melt flow rate at 190 ~ 0.2°C (ASTM D-1238) of 0.4-1.4 g/10 min., a density (ASTM D-1505) of 0.93 ~ 0.02 g/cc and a melt point (ASTM D-3417, D-3418) of 104-140°C. A linear low density polyethylene which can be used is Dowlex 2247A
LLDPE from Dow Chemical Corporation, which has a melt index at 190°C/2.16 kg (ASTM D-1238) of 2.0-2.6 g/10 min., a density (ASTM D-1505) of 0.9150-0.9190 g/cc, and a melt point (D-3417, D-3418 (REF)) of 122-125°C.
The occlusion balloons 58, 60 can be nylon, poly-amide copolymer, polyethylene, polyethylene terephthalate, polyurethane, Kraton (Trade-mark), silicone, latex or any other soft, non-thrombogenic material which will seal against, but not expand, the arterial wall when inflated. The balloons can be tubes which expand on inflation or blow molded balloons.
If the balloon material is compatible with the inner catheter shaft 52, the occlusion balloons 58, 60 can be attached by the thermal bonding techniques discussed above. If not, an adhesive may be used. A nylon which can be used for the occlusion balloons 58, 60 is L25 G Grilamid from EMS-Chemie AG, which has a melting point of 178°C, a density (DIN 53479) of 1.01 kg/dm3, a tensile strength (DIN 53455) of 40 N/mm2, an elongation at yield (DIN 53455) of 10~ and a Shore D
hardness (DIN 53505) of 72.
The dilation-drug delivery catheter 10 of the present invention can be introduced into the vascular system and advanced to the site of the stenosis by a guiding catheter, as would an ordinary dilation catheter. After a guide wire is advanced through the stenosis, the catheter 10 is advanced from the guiding catheter, over the guide wire, through the stenosis. Dilation fluid is injected with a syringe through the port 66 of the Y-adapter 68, to the dilation lumen 38, to dilate the balloon 24 as shown in FIG. 2, opening the stenosis, as would an ordinary dilation catheter. After the stenosis is opened, the dilation balloon 24 is deflated and the dilation portion 20 of the catheter 10 is retracted far enough to reveal the drug delivery ports 56, the proximal occlusion balloon 60 and the perfusion openings 88, if present, putting the catheter into the drug delivery position of FIG. 3. The dilation portion can be retracted by loosening the Tuohy-Borst adapter 70 and withdrawing the outer catheter 22 a suitable distance.
After the dilation portion 20 is retracted, the Tuohy-Borst adapter is tightened.
If the perfusion openings 88 are present, the guide wire is also preferably retracted to a position proximal to the perfusion openings 88 to allow blood to flow through the inner catheter shaft 52. If active perfusion is required, the guide wire can be completely removed and blood or perfluoro-chemicals such as Fluosol~ can be injected with a syringe through tube 76, as is known in the art.
Inflation fluid is then injected with a syringe through the tube 74 to inflate the distal and proximal occlusion balloons 58, 60, until the occlusion balloons meet and seal the arterial wall, isolating the dilated region.
Antithrombolytic, antiproliferative, or any other type of drug can now be injected through tube 72, drug deliver lumen 54 WO 95128196 ~ PCT11895/00052 and drug delivery ports 56, via a syringe, to the dilation site.
After the drug has been applied at the desired pressure and for the desired length of time (typically from about 20 seconds to 3 minutes), the occlusion balloons are deflated and the dilation-drug delivery catheter 10 is withdrawn from the blood vessel. One drug formulation which may be promising is dexamethasone absorbed in poly-lactic/poly-glycolic particles with diameters substantially less than 100 microns. Such particles can adhere to or penetrate the arterial wall.
The surface of the particles can be treated with cell adhesion proteins and peptides based peptides to improve the adhesion of the particles with the arterial wall.
An arginine glycine aspartic acid based peptide which can be used is Teptite 2000~ from Telios Pharmaceuticals, Inc.
The dilation-drug delivery catheter of the present invention provides a single catheter which can perform dual functions, saving time and enabling delivery of drug directly to the dilation site.
The invention further provides a dilation-drug delivery catheter comprising: an outer catheter shaft, a dilation balloon bonded to the catheter shaft, the catheter shaft having an outer wall and an inner wall defining a lumen for providing dilation fluid to the dilation balloon, the inner wall further defining a central lumen, an inner catheter shaft comprising a pair of occlusion balloons at its proximal end, a lumen in fluid communication with the occlusion balloons to provide inflation fluid to the occlusion balloons, a plurality of drug delivery ports between the occlusion balloons, a lumen in fluid communication with the drug delivery ports to provide drugs to the ports, and a guide wire lumen, wherein at least a portion of the distal end of the inner catheter shaft lies within the central lumen, and the outer catheter shaft can be moved with respect to the inner catheter shaft to reveal the distal end of the inner catheter shaft.
Preferably, the drug delivery ports lie within the central lumen prior to the outer catheter shaft being retracted.
DESCRIPTION OF THE DRAWINGS
FIG. 1 is a view of a dilation-drug delivery catheter in accordance with the present invention, wherein the distal portion of the catheter is shown enlarged and in cross-section, in the dilation position of the catheter;
W095/28196 ~ PCTl1895/00052 _5_ FIG. 2 is a cross-sectional view of the distal portion of the catheter of FIG. 1, wherein a dilation balloon is shown inflated;
FIG. 3 is a cross-sectional view of the distal portion of the catheter of FIG_ 1, along line AA of FIG.-1;
FIG. 4 is a cross-sectional view of the distal portion of the catheter of FIG. 1, with its dilation portion retracted, showing the drug delivery position of the catheter; and FIG. 5 is a side view of-the distal portion of the catheter of FIG. 1, wherein two occlusion balloons are inflated.
DESCRIPTION OF THE INVENTION
FIG. 1 is a view of a dilation-drug delivery catheter 10 in accordance withthe present invention, wherein the distal portion of the catheter 10 is shown enlarged and in cross-section. The dilation-drug delivery catheter 10 comprises a dilation portion 20 and a drug delivery portion 50. The dilation portion 20 comprises a dilation balloon 24 bonded to an outer catheter shaft 22 at sites 26 and 28. In FIGS. 1-2, the catheter 10 is shown in its dilation position. In FIG. 1, the dilation balloon 24 is deflated, while in FIG. 2, a cross-sectional view of the distal portion of the dilation-drug delivery catheter 10 of FIG. 1, the dilation balloon 24 is shown inflated.
The outer catheter shaft 22 has an outer wall 34 " 30 and an inner wall 36 which define a dilation lumen for providing dilation fluid to the dilation balloon 22. The inner wall 36 also defines a central lumen 40 for receiving the drug delivery portion 50. FIG.
3 is a cross-sectional view of the dilation-drug W0 95128196 PCf/IB95/00052 delivery catheter 10, through line A-A of FIG. 1,-showing the outer wall 34, inner wall 36, the dilation lumen 38 and the central lumen 40.
The drug delivery portion 50 of the catheter-10 comprises an inner catheter shaft-52, whose distal end is located at least in part within the second lumen 40. The inner catheter shaft 52 includes a-drug -delivery-lumen 54, which communicates with the exterior of the shaft 52 through drug delivery ports 56. -There are preferably between 2-20 circular or oval shaped ports 56 witha diameter or length, respectively, of between about 0.003-0.020 inches.-Three drug delivery ports 56 are provided in this embodiment-. A plurality of such ports are preferably I5 provided to ensure the delivery of adequate-drug to the dilation site. The drug delivery ports-56 preferably lie within the central lumen 40 during dilation. FIG. 3-shows that the drug delivery lumen 54 is preferably semi-circular.
Returning to FIGS- 1-2, a distal occlusion balloon 58 and a proximal occlusion. balloon 60 are-preferably provided to isolate the dilation site during drug delivery. The-occlusion balloons 58, 60 are shown inflated in the side view of Fig. 5. The occlusion balloons 58, 60 maintain the drug in proximity with the portion-of the arterial wall which has been dilated, improving the absorption and efficacy of the drug. An inflation lumen 62 in the inner catheter shaft 52 is provided to convey inflation fluid to the occlusion balloons 58, 60.
The inner-catheter shaft 52 also typically includes a guide wire lumen 64. The-inflation lumen 62 and guide wire lumen 64 are shown in cross-section in Fig. 3. The inflation lumen 62 is also preferably-W095/28196 ~ PCT/1895/00052 semi=circular and in the same radial plane as the drug delivery lumen 54. To deliver an adequate amount of drug in the time allowed, the drug delivery lumen 54 will generally need to be larger than the inflation lumen 62. In the embodiment illustrated, the portion of the inner catheter shaft 52 including the distal occlusion balloon 58 extends beyond the distal tip of the dilation portion 20 while the catheter is in its dilation position. The distal occlusion balloon 58 can lie within-the second lumen 40 in the dilation position, as well.
In FIGS. 4 and 5, the dilation-drug delivery catheter 10 of the present invention is shown in its drug delivery position. In FIG. 4, the dilation portion 20 is shown retracted to fully reveal the distal end of the drug delivery portion 50 of the catheter 10, which comprises the occlusion balloons 58, 60, and the drug delivery ports 56. FIG. 5 is a side view of the catheter 10, showing the occlusion balloons 58, 60, inflated as they would be immediately prior to and during drug delivery. The present invention enables a plurality of drug delivery ports 56 to be provided between the occlusion balloons 58, 60, better ensuring the delivery of an adequate quantity of drug. Perfusion openings 88 are preferably provided through the walls of the inner catheter shaft 52 to the guide wire lumen 64 as shown in FIG. 5, to provide a path for blood to flow beyond the occluded site.- There are preferably between 2-20 circular or oval perfusion openings 88 with a diameter or length, respectively, of between about 0.003-0.020 inches. Three perfusion openings 88 are provided in this embodiment.
-g-Returning to FIG. 1, the proximal end o~ the-catheter 10 includes a Y-adaptor 68 including a port 66; as is known--iri the art-: A tube (not shown) is connected tothe dilation lumen 38 of the outer -cathetez shaft 22 and-extends through the port 66.
The outer catheter shaft ends within the Y-adaptor 68, proximate the base of the port 66. A syringe can be used-to supply the dilation fluid through the port 66 into the dilation lumen-38, also as is known in the art. A Tuohy-BOrst adapter 70 is threaded-on--the central port of the Y-adaptor 68. The inner catheter shaft 52 extends through the Y-adaptor--68 and Tuohy-Borst adapter 7D. In-this-embodiment, three tubes 72, 74, and 76 are connected to the drug delivery lumen 54, inflation lumen 62 and guide wire-lumen 64, respectively, of-the innercatheter shaft52. Hubs 78 are connected to each tube. The guide wire can be inserted into the guide wire lumen 64, through tube 76. Syringes can also be used to supply inflation fluid for the occlusion balloons 58, 6D and any desired drug through tubes=74 and 72, respectively.
The outer diameter of the catheter 10 and the deflated dilation balloon 24 is preferably ho greater than about 0.042-0.050 inches, so that it can be used with a 7 or 8 French guiding catheter. To accommodate the-tubes 72, 74, 76, the portion of the inner catheter shaft 52 which extends out of the Tuohy-Borst adapter 68 flares to an outer diameter of-about 0.200 inches at about point 80. The tubes 72, 74, 76, are held together by a heat shrink tubing 82.
The distal end 84 of the-inner catheter shaft 52 preferably includes a resilient tip 96 which comprises a material softer than that of the inner catheter shaft 22. The tip 96 spreads or bends when WO 95128196 PCT/lB95/00052 it contacts body tissue, easing the catheter's passage through the vascular system and helping to avoid tissue damage. The tip 96 can be made of ultra -low density palyethylene 4603 from Dow Chemical Corporation, which has a melt flow rate at 190C
(ASTM D-1238) of 0.7-0.9 g/l0,min. and a density (ASTM D-792) of 0.9030-0.9070 g/cc. The tip 96 can also be a,nylon, such as PEBA 25D from EIf Atochem Deutschland GmbH, which has an ultimate tensile -strength (ASTM D-638) of 4950 psi min., an ultimate elongation (ASTM-638) of 640% min., a flexural modulus (ASTM D-790) of-2100 psi min., a Durometer (ASTM D-2240) of 25D t 4D, and a melting point (ASTM
D-3418) of 142-153C. The tip 96 can be connected 1~ to the inner_catheter shaft 22 by an adhesive or thermal bonding.
Radiopaque markers 86 of gold or tantalum, for example, are also preferably prbvided on the inner catheter shaft 52 within the occlusion balloons 58, 60;--and on the outercatheter shaft 22 within the dilation balloon 24, as shown, to assist in monitoring the positionof the catheter on a fluoroscope during a PTA or PTCA procedure, as is known in the art. The inner catheter shaft 52 and occlusion balloons 58, 60, are preferably coated with a lubricous material, such as silicone, acrylimide, or a hydrophilic polyurethane coating, to ease retraction of the dilation portion 20 after dilation.
The outer catheter shaft 22 and dilation balloon 24 can be similarly coated to ease its advance through a guiding catheter and a lesion, as is known in the art.
The inner and outer catheter shafts can be of any material suitable for catheters, such as linear R'0 95/28196 9 ~ PCT/IB95100052 low density or high density polyethylene, nylon, polyurethane polypropylene, silicone rubber, or -other non-thrombogenic materials. A linear low density polyethylene which can be used for the outer catheter shaft 22 is Dowlex 2038 from Dow Chemical Company, which hasa melt-flow rate at 190°C (ASTM-D-1238) of 0.85-1_15 g/10 min. and a density (ASTM D-792) of 0.9330-0.9370 g/cc. A high density polyethylene which can be used for the outer catheter shaft 22 is LB 8320-00 from Quantum Chemical Corporation, which has a melt flow rate at 190°C
(ASTM D-1238) of 0.20-0_36 g/10 min. and a density (D-1505) of-0.9566 gjcc min.
A nylon which can be used for the inner or outer catheter shafts 22, 52 is nylon 12, such as L21d1F
Veatamed from Huls America Inc., which-has a relative viscosity (ISO 307) of-2_05-2.22 and a water content (ASTM D-4019) of 0.10 maximum. Another nylon which can be used is PEBA 70D from Elf Atochem, which has an ultimate tensile strength (ASTM D-638)of 8300 psi min., an ultimate elongation (ASTM D-638) of 400%
min., a flexural modulus (ASTM D-790) of 67,000 psi min., a Durometer (D-2240) of fi9D ~ 4D and a melting point (ASTM D-3418) of-160°-180°C.
A high density polyethylene which can be used for the inner-catheter shaft 52 is LM6007 from Quantum Chemical Corporation, which has the following characteristics:
Ultimate Tensile Strength 4400 psi min.
(ASTM D-638) Ultimate Elongation % 600% min.
at break (ASTM D-638) Durometer D Scale 68 ~ 4.5 (ASTM D-2240) WO 95128196 ~ ~ PCT/1895/00052 Melt Flow Rate at 240°C 2160g 0.070 (REF) (ASTM D-1238) Flexural Modulus at Room Temperature 220,000 psi min.
(ASTM D-790, Procedure B) Vicat Softening Point °C. 125°C (REF) (ASTM D-1525) The outer catheter shaft 22 and inner catheter shaft 52 are extruded separately --To-form the flared portion of the inner catheter shaft 52, a bump extrusion process can be used, as is known in the art. After extrusion of the inner catheter shaft 52, the tubes 72, 74 and 76 are inserted into the shaft's wider portion and thermally bonded in place. An adhesive can be used, as well. A tube (not shown) is inserted and similarly bonded to the dilation lumen 38 of the outer catheter shaft 22. That tube extends through the port 66 of the Tuohy-Borst adaptor 70.
After formation of the inner catheter shaft 52, the perfusion openings 88 and drug delivery ports 56 are made. Passages through the shaft 52 to the inflation lumen 62 proximate the intended location of the occlusion balloons, are also made. The radiopaque markers 86 are added to the inner and outer catheter shafts, as well. All these procedures are known in the art.
The dilation balloon 24 can be of any type and size appropriate for PTA and PTCA procedures. For example, the balloon 22 can be of polyethylene, polyethylene terephthalate, nylon, polyurethane or any other material suitable for a dilation balloon. The balloon 24 can be compliant, non-compliant or semi-compliant. The dilation balloon 24 can be attached to the outer catheter shaft 22 through thermal bond-ing, including laser bonding or ultrasonic bonding, or with an adhesive, as is known in the art. An apparatus and process for laser bonding angioplasty balloon catheters is disclosed in U. S. Patent No. 5,267,959 which was filed on November 29, 1991 by the inventor of the present invention and is assigned to the assignee of the present invention. The balloon 22 is preferably of the same or compatible material as the catheter shaft 28 to enable thermal bonding.
A low density polyethylene which can be used for the dilation balloon 24 is P. E. 1031 from Rexene Corporation, which has a melt flow rate at 190 ~ 0.2°C (ASTM D-1238) of 0.4-1.4 g/10 min., a density (ASTM D-1505) of 0.93 ~ 0.02 g/cc and a melt point (ASTM D-3417, D-3418) of 104-140°C. A linear low density polyethylene which can be used is Dowlex 2247A
LLDPE from Dow Chemical Corporation, which has a melt index at 190°C/2.16 kg (ASTM D-1238) of 2.0-2.6 g/10 min., a density (ASTM D-1505) of 0.9150-0.9190 g/cc, and a melt point (D-3417, D-3418 (REF)) of 122-125°C.
The occlusion balloons 58, 60 can be nylon, poly-amide copolymer, polyethylene, polyethylene terephthalate, polyurethane, Kraton (Trade-mark), silicone, latex or any other soft, non-thrombogenic material which will seal against, but not expand, the arterial wall when inflated. The balloons can be tubes which expand on inflation or blow molded balloons.
If the balloon material is compatible with the inner catheter shaft 52, the occlusion balloons 58, 60 can be attached by the thermal bonding techniques discussed above. If not, an adhesive may be used. A nylon which can be used for the occlusion balloons 58, 60 is L25 G Grilamid from EMS-Chemie AG, which has a melting point of 178°C, a density (DIN 53479) of 1.01 kg/dm3, a tensile strength (DIN 53455) of 40 N/mm2, an elongation at yield (DIN 53455) of 10~ and a Shore D
hardness (DIN 53505) of 72.
The dilation-drug delivery catheter 10 of the present invention can be introduced into the vascular system and advanced to the site of the stenosis by a guiding catheter, as would an ordinary dilation catheter. After a guide wire is advanced through the stenosis, the catheter 10 is advanced from the guiding catheter, over the guide wire, through the stenosis. Dilation fluid is injected with a syringe through the port 66 of the Y-adapter 68, to the dilation lumen 38, to dilate the balloon 24 as shown in FIG. 2, opening the stenosis, as would an ordinary dilation catheter. After the stenosis is opened, the dilation balloon 24 is deflated and the dilation portion 20 of the catheter 10 is retracted far enough to reveal the drug delivery ports 56, the proximal occlusion balloon 60 and the perfusion openings 88, if present, putting the catheter into the drug delivery position of FIG. 3. The dilation portion can be retracted by loosening the Tuohy-Borst adapter 70 and withdrawing the outer catheter 22 a suitable distance.
After the dilation portion 20 is retracted, the Tuohy-Borst adapter is tightened.
If the perfusion openings 88 are present, the guide wire is also preferably retracted to a position proximal to the perfusion openings 88 to allow blood to flow through the inner catheter shaft 52. If active perfusion is required, the guide wire can be completely removed and blood or perfluoro-chemicals such as Fluosol~ can be injected with a syringe through tube 76, as is known in the art.
Inflation fluid is then injected with a syringe through the tube 74 to inflate the distal and proximal occlusion balloons 58, 60, until the occlusion balloons meet and seal the arterial wall, isolating the dilated region.
Antithrombolytic, antiproliferative, or any other type of drug can now be injected through tube 72, drug deliver lumen 54 WO 95128196 ~ PCT11895/00052 and drug delivery ports 56, via a syringe, to the dilation site.
After the drug has been applied at the desired pressure and for the desired length of time (typically from about 20 seconds to 3 minutes), the occlusion balloons are deflated and the dilation-drug delivery catheter 10 is withdrawn from the blood vessel. One drug formulation which may be promising is dexamethasone absorbed in poly-lactic/poly-glycolic particles with diameters substantially less than 100 microns. Such particles can adhere to or penetrate the arterial wall.
The surface of the particles can be treated with cell adhesion proteins and peptides based peptides to improve the adhesion of the particles with the arterial wall.
An arginine glycine aspartic acid based peptide which can be used is Teptite 2000~ from Telios Pharmaceuticals, Inc.
The dilation-drug delivery catheter of the present invention provides a single catheter which can perform dual functions, saving time and enabling delivery of drug directly to the dilation site.
Claims (12)
1. A dilation-drug delivery catheter (10) comprising:
a dilation portion (20) comprising an outer catheter shaft (22), a dilation balloon (24) attached to the outer catheter shaft (22), the outer catheter shaft (22) comprising a dilation lumen (38) for providing inflation fluid to the dilation balloon (24) and a central lumen (40); and a drug delivery portion (50) located at least in part within the central lumen (40), the drug delivery portion (50) comprising an inner catheter shaft (52) having at least one drug delivery port (56) and defining a drug delivery lumen (54) for providing a drug to the drug delivery port (56), the drug delivery port (56) being located in a portion of the inner catheter shaft (52) lying within the central lumen (40), wherein the dilation portion (20) can move with respect to the drug delivery portion (50) such that the dilation portion (20) can be retracted from the distal end of the drug delivery portion (50), revealing the drug delivery port (56), the drug delivery portion (50) further comprising:
a first occlusion balloon (58) distal to the drug delivery port;
an inflation lumen (62) in fluid communication with the first occlusion balloon (58); and a second occlusion balloon (60) proximal to the drug delivery port (56);
wherein the dilation portion (20) can be retracted to reveal the first occlusion balloon (58).
a dilation portion (20) comprising an outer catheter shaft (22), a dilation balloon (24) attached to the outer catheter shaft (22), the outer catheter shaft (22) comprising a dilation lumen (38) for providing inflation fluid to the dilation balloon (24) and a central lumen (40); and a drug delivery portion (50) located at least in part within the central lumen (40), the drug delivery portion (50) comprising an inner catheter shaft (52) having at least one drug delivery port (56) and defining a drug delivery lumen (54) for providing a drug to the drug delivery port (56), the drug delivery port (56) being located in a portion of the inner catheter shaft (52) lying within the central lumen (40), wherein the dilation portion (20) can move with respect to the drug delivery portion (50) such that the dilation portion (20) can be retracted from the distal end of the drug delivery portion (50), revealing the drug delivery port (56), the drug delivery portion (50) further comprising:
a first occlusion balloon (58) distal to the drug delivery port;
an inflation lumen (62) in fluid communication with the first occlusion balloon (58); and a second occlusion balloon (60) proximal to the drug delivery port (56);
wherein the dilation portion (20) can be retracted to reveal the first occlusion balloon (58).
2. The dilation-drug delivery catheter (10) of claim 1, wherein the inflation lumen (62) is in fluid communication with the first (58) and second (60) occlusion balloons.
3. The dilation-drug delivery catheter (10) of claim 1 or claim 2 wherein there are a plurality of drug delivery ports (56), at least some of which lie within the central lumen (40) prior to the drug delivery portion (50) being retracted.
4. The dilation-drug delivery catheter (10) of any one of claims 1 to 3 further comprising a lubricious layer between a wall of the central lumen (40) and the inner catheter shaft (52).
5. The dilation-drug delivery catheter (10) of any one of claims 1 to 4 wherein the occlusion balloons (58, 60) comprise inflatable plastic tubes.
6. The dilation-drug delivery catheter (10) of any one of claims 1 to 5 wherein the occlusion balloons (58, 60) are blow molded.
7. The dilation-drug delivery catheter (10) of any one of claims 1 to 6 further comprising perfusion means for allowing blood to flow through the dilation-drug delivery catheter (10), beyond the occlusion balloon (58).
8. The dilation-drug delivery catheter (10) of any one of claims 1 to 7 wherein the inner catheter shaft (52) further comprises a guide wire lumen (64) and the perfusion means comprise at least one passage through the inner catheter shaft (52) to the guide wire lumen (64).
9. A dilation-drug delivery catheter (10) comprising a dilation portion (20) comprising a dilation balloon (24) and a drug delivery portion (50) having a distal end, wherein the portions can be moved with respect to each other, the catheter having a dilation position, wherein the distal end of the drug delivery portion (50) is located at least in part within the dilation portion (20), and a drug delivery position, wherein the dilation portion (20) is retracted to reveal the distal end of the drug delivery portion (50); and wherein the dilation portion (20) further comprises a dilation lumen (38) for providing dilation fluid to the dilation balloon (24) and a central lumen (40), wherein the drug delivery portion (50) is located at least in part, within the central lumen (40) and wherein the drug delivery portion (50) comprises a catheter shaft comprising an inflation lumen (62) and a drug delivery lumen (54); and the distal end of the drug delivery portion (20) comprises a pair of occlusion balloons (58, 60) in fluid communication with the inflation lumen (62) and a plurality of drug delivery ports (56) between the occlusion balloons (58, 60), the drug delivery ports (56) being in fluid communication with the drug delivery lumen (54), wherein, in the drug delivery position, the dilation portion (20) is retracted to reveal the occlusion balloons (58, 60) and the drug delivery ports (56).
10. A dilation-drug delivery catheter (10) comprising:
an outer catheter shaft (22), a dilation balloon (24) bonded to the catheter shaft (22), the catheter shaft (22) having an outer wall and an inner wall defining a lumen for providing dilation fluid to the dilation balloon (24), the inner wall further defining a central lumen, an inner catheter shaft (52) comprising a pair of occlusion balloons (58, 60) at its proximal end, a lumen in fluid communication with the occlusion balloons (58, 60) to provide inflation fluid to the occlusion balloons (58, 60), a plurality of drug delivery ports (56) between the occlusion balloons (58, 60), a lumen in fluid communication with the drug delivery ports (56) to provide drugs to the ports (56), and a guide wire lumen (64), wherein at least a portion of the distal end of the inner catheter shaft (52) lies within the central lumen (40), and the outer catheter shaft (22) can be moved with respect to the inner catheter shaft (52) to reveal the distal end of the inner catheter shaft (52).
an outer catheter shaft (22), a dilation balloon (24) bonded to the catheter shaft (22), the catheter shaft (22) having an outer wall and an inner wall defining a lumen for providing dilation fluid to the dilation balloon (24), the inner wall further defining a central lumen, an inner catheter shaft (52) comprising a pair of occlusion balloons (58, 60) at its proximal end, a lumen in fluid communication with the occlusion balloons (58, 60) to provide inflation fluid to the occlusion balloons (58, 60), a plurality of drug delivery ports (56) between the occlusion balloons (58, 60), a lumen in fluid communication with the drug delivery ports (56) to provide drugs to the ports (56), and a guide wire lumen (64), wherein at least a portion of the distal end of the inner catheter shaft (52) lies within the central lumen (40), and the outer catheter shaft (22) can be moved with respect to the inner catheter shaft (52) to reveal the distal end of the inner catheter shaft (52).
11. The dilation-drug delivery catheter (10) of claim 10 wherein all of the drug delivery ports (56) lie within the central lumen (40).
12. The dilation-drug delivery catheter (10) of claim 10 or 11, wherein the inner catheter shaft (52) further comprises perfusion passages proximal to the occlusion balloons (58, 60), the perfusion passages being in fluid communication with the guide wire lumen (64).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/227,254 US5415636A (en) | 1994-04-13 | 1994-04-13 | Dilation-drug delivery catheter |
US08/227,254 | 1994-04-13 | ||
PCT/IB1995/000052 WO1995028196A1 (en) | 1994-04-13 | 1995-01-23 | A dilation-drug delivery catheter |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2186493A1 CA2186493A1 (en) | 1995-10-26 |
CA2186493C true CA2186493C (en) | 2000-09-05 |
Family
ID=22852390
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002186493A Expired - Fee Related CA2186493C (en) | 1994-04-13 | 1995-01-23 | A dilation-drug delivery catheter |
Country Status (6)
Country | Link |
---|---|
US (2) | US5415636A (en) |
EP (1) | EP0755279A1 (en) |
JP (1) | JP2930422B2 (en) |
AU (1) | AU699000B2 (en) |
CA (1) | CA2186493C (en) |
WO (1) | WO1995028196A1 (en) |
Families Citing this family (153)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU4191989A (en) * | 1988-08-24 | 1990-03-23 | Marvin J. Slepian | Biodegradable polymeric endoluminal sealing |
US5591129A (en) * | 1994-03-02 | 1997-01-07 | Scimed Life Systems, Inc. | Perfusion balloon angioplasty catheter |
CA2188407A1 (en) * | 1994-04-20 | 1995-11-02 | Ronald J. Solar | Active perfusion dilatation catheter |
US5810767A (en) * | 1994-05-11 | 1998-09-22 | Localmed, Inc. | Method and apparatus for pressurized intraluminal drug delivery |
CA2193946A1 (en) * | 1994-06-24 | 1996-01-04 | Manouchehr Miraki | Catheters having a reusable proximal body |
US5558652A (en) * | 1994-10-06 | 1996-09-24 | B. Braun Medical, Inc. | Introducer with radiopaque marked tip and method of manufacture therefor |
US5702372A (en) | 1995-02-08 | 1997-12-30 | Medtronic, Inc. | Lined infusion catheter |
US6210356B1 (en) * | 1998-08-05 | 2001-04-03 | Ekos Corporation | Ultrasound assembly for use with a catheter |
US6176842B1 (en) * | 1995-03-08 | 2001-01-23 | Ekos Corporation | Ultrasound assembly for use with light activated drugs |
US5674198A (en) * | 1995-06-23 | 1997-10-07 | Cordis Corporation | Tandem balloon catheter |
US5752934A (en) * | 1995-09-18 | 1998-05-19 | W. L. Gore & Associates, Inc. | Balloon catheter device |
US20060271091A1 (en) * | 1995-09-18 | 2006-11-30 | Campbell Carey V | Balloon catheter device |
US5868704A (en) * | 1995-09-18 | 1999-02-09 | W. L. Gore & Associates, Inc. | Balloon catheter device |
US6440097B1 (en) | 1995-10-06 | 2002-08-27 | Target Therapeutics, Inc. | Balloon catheter with delivery side holes |
US6283951B1 (en) * | 1996-10-11 | 2001-09-04 | Transvascular, Inc. | Systems and methods for delivering drugs to selected locations within the body |
DE69638011D1 (en) | 1995-10-13 | 2009-10-08 | Medtronic Vascular Inc | NGRIFF |
US6113567A (en) * | 1995-10-25 | 2000-09-05 | Becker; Bruce B. | Lacrimal silicone tube with reduced friction |
US5843104A (en) * | 1995-11-21 | 1998-12-01 | Samuels; Peter B. | Method of removing blood vessels from the human body |
US5882334A (en) * | 1995-12-04 | 1999-03-16 | Target Therapeutics, Inc. | Balloon/delivery catheter assembly with adjustable balloon positioning |
US5823996A (en) * | 1996-02-29 | 1998-10-20 | Cordis Corporation | Infusion balloon catheter |
US6254571B1 (en) * | 1996-04-18 | 2001-07-03 | Applied Medical Resources Corporation | Remote clot management |
US6544276B1 (en) * | 1996-05-20 | 2003-04-08 | Medtronic Ave. Inc. | Exchange method for emboli containment |
US6652480B1 (en) | 1997-03-06 | 2003-11-25 | Medtronic Ave., Inc. | Methods for reducing distal embolization |
US6152909A (en) * | 1996-05-20 | 2000-11-28 | Percusurge, Inc. | Aspiration system and method |
US6270477B1 (en) * | 1996-05-20 | 2001-08-07 | Percusurge, Inc. | Catheter for emboli containment |
US20010049517A1 (en) | 1997-03-06 | 2001-12-06 | Gholam-Reza Zadno-Azizi | Method for containing and removing occlusions in the carotid arteries |
US6022336A (en) | 1996-05-20 | 2000-02-08 | Percusurge, Inc. | Catheter system for emboli containment |
US20070161968A1 (en) * | 1996-06-04 | 2007-07-12 | Vance Products Inc., Dba Cood Urological Inc. | Implantable medical device with pharmacologically active ingredient |
EP0835673A3 (en) | 1996-10-10 | 1998-09-23 | Schneider (Usa) Inc. | Catheter for tissue dilatation and drug delivery |
US6193685B1 (en) * | 1996-11-26 | 2001-02-27 | Schneider (Usa) Inc. | Perfusion catheter |
EP0946222A1 (en) * | 1996-12-13 | 1999-10-06 | Data Sciences International, Inc. | Biocompatible medical devices with polyurethane surface |
DE69839007T2 (en) * | 1997-02-04 | 2009-01-22 | Cook Urological Inc., Spencer | DRAINAGE CATHETER TO BE INSERTED BY THE BELLOW CEILING |
US5968064A (en) * | 1997-02-28 | 1999-10-19 | Lumend, Inc. | Catheter system for treating a vascular occlusion |
US6508825B1 (en) | 1997-02-28 | 2003-01-21 | Lumend, Inc. | Apparatus for treating vascular occlusions |
US6217549B1 (en) | 1997-02-28 | 2001-04-17 | Lumend, Inc. | Methods and apparatus for treating vascular occlusions |
US6010449A (en) * | 1997-02-28 | 2000-01-04 | Lumend, Inc. | Intravascular catheter system for treating a vascular occlusion |
US6120516A (en) * | 1997-02-28 | 2000-09-19 | Lumend, Inc. | Method for treating vascular occlusion |
US6849068B1 (en) | 1997-03-06 | 2005-02-01 | Medtronic Ave, Inc. | Aspiration catheter |
AU6688398A (en) * | 1997-03-06 | 1998-09-22 | Percusurge, Inc. | Intravascular aspiration system |
US6136007A (en) * | 1997-04-17 | 2000-10-24 | St. Jude Medical Cardiovascular Group, Inc, | Apparatus for handling tubing used in medical procedures |
JPH10290837A (en) * | 1997-04-18 | 1998-11-04 | Kanegafuchi Chem Ind Co Ltd | Balloon catheter and manufacture of multi-lumen shaft used therefor |
US6676626B1 (en) | 1998-05-01 | 2004-01-13 | Ekos Corporation | Ultrasound assembly with increased efficacy |
US6723063B1 (en) | 1998-06-29 | 2004-04-20 | Ekos Corporation | Sheath for use with an ultrasound element |
US6582392B1 (en) | 1998-05-01 | 2003-06-24 | Ekos Corporation | Ultrasound assembly for use with a catheter |
ATE267625T1 (en) * | 1997-06-23 | 2004-06-15 | Schneider Europ Gmbh | CATHETER ARRANGEMENT |
DE19732965A1 (en) * | 1997-07-31 | 1999-02-18 | Knoerig Joachim Michael Dr | Balloon catheter |
US6090069A (en) * | 1997-08-05 | 2000-07-18 | Walker; Frank J. | Irrigation and drainage urinary catheter |
US6056721A (en) * | 1997-08-08 | 2000-05-02 | Sunscope International, Inc. | Balloon catheter and method |
US6217527B1 (en) * | 1998-09-30 | 2001-04-17 | Lumend, Inc. | Methods and apparatus for crossing vascular occlusions |
US6398798B2 (en) | 1998-02-28 | 2002-06-04 | Lumend, Inc. | Catheter system for treating a vascular occlusion |
US6179813B1 (en) * | 1998-04-24 | 2001-01-30 | Scimed Life Systems, Inc. | Vascular infusion device |
US6148222A (en) * | 1998-07-10 | 2000-11-14 | Cardiocommand, Inc. | Esophageal catheters and method of use |
US6210365B1 (en) * | 1998-08-14 | 2001-04-03 | Cardiovention, Inc. | Perfusion catheter system having sutureless arteriotomy seal and methods of use |
US6955661B1 (en) | 1999-01-25 | 2005-10-18 | Atrium Medical Corporation | Expandable fluoropolymer device for delivery of therapeutic agents and method of making |
US7637886B2 (en) * | 1999-01-25 | 2009-12-29 | Atrium Medical Corporation | Expandable fluoropolymer device and method of making |
US6395208B1 (en) | 1999-01-25 | 2002-05-28 | Atrium Medical Corporation | Method of making an expandable fluoropolymer device |
US6709427B1 (en) * | 1999-08-05 | 2004-03-23 | Kensey Nash Corporation | Systems and methods for delivering agents into targeted tissue of a living being |
US7892201B1 (en) | 1999-08-27 | 2011-02-22 | Gore Enterprise Holdings, Inc. | Balloon catheter and method of mounting same |
US6592567B1 (en) * | 1999-12-07 | 2003-07-15 | Chf Solutions, Inc. | Kidney perfusion catheter |
US8172783B1 (en) | 1999-12-30 | 2012-05-08 | Advanced Cardiovascular Systems, Inc | Conduit system for isolation of fluids in biological tissues |
US6685672B1 (en) | 2000-07-13 | 2004-02-03 | Edwards Lifesciences Corporation | Multi-balloon drug delivery catheter for angiogenesis |
LU90613B1 (en) * | 2000-07-24 | 2002-01-25 | Crash Holding S A | Intra-and peri-articular catheter |
US6464662B1 (en) * | 2000-07-26 | 2002-10-15 | Image-Guided Neurologics, Inc. | Drug delivery and catheter systems, apparatus and processes |
US6572579B1 (en) | 2000-09-13 | 2003-06-03 | Image-Guided Neurologics, Inc. | Drug delivery and catheter systems, apparatus and processes |
BR0107330A (en) * | 2000-10-16 | 2002-08-27 | Lumend Inc | Apparatus for the treatment of a vascular occlusion |
US20020091355A1 (en) * | 2000-11-17 | 2002-07-11 | Ascend Medical, Inc. | Compliant delivery catheter |
WO2002045598A2 (en) * | 2000-12-05 | 2002-06-13 | Lumend, Inc. | Catheter system for vascular re-entry from a sub-intimal space |
US6692458B2 (en) | 2000-12-19 | 2004-02-17 | Edwards Lifesciences Corporation | Intra-pericardial drug delivery device with multiple balloons and method for angiogenesis |
US7481790B2 (en) * | 2000-12-27 | 2009-01-27 | Advanced Cardiovascular Systems, Inc. | Vessel enlargement by arteriogenic factor delivery |
US6669662B1 (en) | 2000-12-27 | 2003-12-30 | Advanced Cardiovascular Systems, Inc. | Perfusion catheter |
US6964439B2 (en) * | 2001-01-11 | 2005-11-15 | Aisin Seiki Kabushiki Kaisha | Vehicle door handle device |
AU2002243987A1 (en) * | 2001-02-13 | 2002-08-28 | Lumend, Inc. | Method and apparatus for micro-dissection of vascular occlusions |
US6625486B2 (en) | 2001-04-11 | 2003-09-23 | Advanced Cardiovascular Systems, Inc. | Method and apparatus for intracellular delivery of an agent |
US6726674B2 (en) | 2001-09-04 | 2004-04-27 | Jomed Gmbh | Methods for minimally invasive, localized delivery of sclerotherapeutic agents |
EP1453425B1 (en) | 2001-12-03 | 2006-03-08 | Ekos Corporation | Catheter with multiple ultrasound radiating members |
US7141044B2 (en) | 2001-12-11 | 2006-11-28 | Ekos Corporation | Alternate site gene therapy |
AU2003214945A1 (en) * | 2002-02-01 | 2003-09-02 | Robert J. Goldman | Multi-function catheter and use thereof |
US20050267407A1 (en) * | 2002-02-01 | 2005-12-01 | Vascular Designs, Inc. | Multi-function catheter and use thereof |
US8062251B2 (en) * | 2002-02-01 | 2011-11-22 | Vascular Designs, Inc. | Multi-function catheter and use thereof |
US8226629B1 (en) | 2002-04-01 | 2012-07-24 | Ekos Corporation | Ultrasonic catheter power control |
US6921371B2 (en) * | 2002-10-14 | 2005-07-26 | Ekos Corporation | Ultrasound radiating members for catheter |
US20060047261A1 (en) * | 2004-06-28 | 2006-03-02 | Shailendra Joshi | Intra-arterial catheter for drug delivery |
US7862575B2 (en) * | 2003-05-21 | 2011-01-04 | Yale University | Vascular ablation apparatus and method |
US20040236410A1 (en) * | 2003-05-22 | 2004-11-25 | Atrium Medical Corp. | Polymeric body formation |
US20040236279A1 (en) * | 2003-05-22 | 2004-11-25 | Atrium Medical Corp. | Gaseous therapeutic agent delivery |
US20040236278A1 (en) * | 2003-05-22 | 2004-11-25 | Atrium Medical Corp. | Therapeutic agent delivery |
ATE427131T1 (en) * | 2003-06-10 | 2009-04-15 | Lumend Inc | CATHETER SYSTEM AND METHOD FOR OPENING BLOOD VESSEL OCCLUSIONS |
US20050004594A1 (en) * | 2003-07-02 | 2005-01-06 | Jeffrey Nool | Devices and methods for aspirating from filters |
US7736362B2 (en) * | 2003-09-15 | 2010-06-15 | Boston Scientific Scimed, Inc. | Catheter balloons |
US20050226991A1 (en) * | 2004-04-07 | 2005-10-13 | Hossainy Syed F | Methods for modifying balloon of a catheter assembly |
US20060111704A1 (en) * | 2004-11-22 | 2006-05-25 | Rox Medical, Inc. | Devices, systems, and methods for energy assisted arterio-venous fistula creation |
ES2485387T3 (en) | 2005-11-07 | 2014-08-13 | Amorcyte, Inc. | Compositions and methods of repair of vascular lesions |
US8172792B2 (en) | 2005-12-27 | 2012-05-08 | Tyco Healthcare Group Lp | Embolic protection systems for bifurcated conduits |
US8287503B2 (en) * | 2006-03-13 | 2012-10-16 | Applied Medical Resources Corporation | Balloon trocar |
US8147453B2 (en) | 2006-03-13 | 2012-04-03 | Applied Medical Resources Corporation | Balloon trocar |
US9180279B2 (en) | 2006-08-07 | 2015-11-10 | W. L. Gore & Associates, Inc. | Inflatable imbibed polymer devices |
US8460240B2 (en) * | 2006-08-07 | 2013-06-11 | W. L. Gore & Associates, Inc. | Inflatable toroidal-shaped balloons |
US20080125711A1 (en) | 2006-08-07 | 2008-05-29 | Alpini Alfred A | Catheter balloons with integrated non-distensible seals |
US7785290B2 (en) * | 2006-08-07 | 2010-08-31 | Gore Enterprise Holdings, Inc. | Non-shortening high angle wrapped balloons |
US20080140173A1 (en) * | 2006-08-07 | 2008-06-12 | Sherif Eskaros | Non-shortening wrapped balloon |
US20080097300A1 (en) * | 2006-08-07 | 2008-04-24 | Sherif Eskaros | Catheter balloon with multiple micropleats |
US20080097374A1 (en) * | 2006-08-07 | 2008-04-24 | Korleski Joseph E | Inflatable shaped balloons |
CA2921604C (en) | 2006-09-13 | 2020-02-25 | Vascular Insights Llc | Vascular treatment device |
US8147413B2 (en) * | 2006-10-12 | 2012-04-03 | Innoscion, Llc | Image guided catheter having deployable balloons and pericardial access procedure |
US8192363B2 (en) | 2006-10-27 | 2012-06-05 | Ekos Corporation | Catheter with multiple ultrasound radiating members |
ITMI20062333A1 (en) * | 2006-12-05 | 2008-06-06 | Mario Salerno | DEVICE TO ASSIST THE SCLORESANT TREATMENT OF VARICOSE VEINS |
US10182833B2 (en) | 2007-01-08 | 2019-01-22 | Ekos Corporation | Power parameters for ultrasonic catheter |
US8617205B2 (en) | 2007-02-01 | 2013-12-31 | Cook Medical Technologies Llc | Closure device |
WO2008094706A2 (en) * | 2007-02-01 | 2008-08-07 | Cook Incorporated | Closure device and method of closing a bodily opening |
US9044568B2 (en) | 2007-06-22 | 2015-06-02 | Ekos Corporation | Method and apparatus for treatment of intracranial hemorrhages |
US8292907B2 (en) * | 2007-08-31 | 2012-10-23 | Cook Medical Technologies Llc | Balloon assisted occlusion device |
WO2009079415A1 (en) * | 2007-12-14 | 2009-06-25 | Ekos Corporation | Ultrasound pulse shaping |
US8162879B2 (en) * | 2008-09-22 | 2012-04-24 | Tyco Healthcare Group Lp | Double balloon catheter and methods for homogeneous drug delivery using the same |
US20100130835A1 (en) * | 2008-09-30 | 2010-05-27 | Rox Medical, Inc. | Methods for screening and treating patients with compromised cardiopulmonary function |
US20100261662A1 (en) * | 2009-04-09 | 2010-10-14 | Endologix, Inc. | Utilization of mural thrombus for local drug delivery into vascular tissue |
US20100292641A1 (en) * | 2009-05-15 | 2010-11-18 | Bandula Wijay | Targeted drug delivery device and method |
WO2011012575A1 (en) * | 2009-07-27 | 2011-02-03 | Scarcell Therapeutics | Balloon catheter device |
EP2491114B8 (en) | 2009-10-23 | 2017-01-25 | Amorcyte, Inc. | Compositions and uses for treating progressive myocardial injury due to a vascular insufficiency |
US9457171B2 (en) | 2009-12-02 | 2016-10-04 | Renovorx, Inc. | Devices, methods and kits for delivery of therapeutic materials to a target artery |
US8821476B2 (en) | 2009-12-02 | 2014-09-02 | Renovorx, Inc. | Devices, methods and kits for delivery of therapeutic materials to a pancreas |
US10512761B2 (en) | 2009-12-02 | 2019-12-24 | Renovorx, Inc. | Methods for delivery of therapeutic materials to treat pancreatic cancer |
EP2627265B8 (en) | 2010-10-15 | 2019-02-20 | Cook Medical Technologies LLC | Occlusion device for blocking fluid flow through bodily passages |
US9585667B2 (en) | 2010-11-15 | 2017-03-07 | Vascular Insights Llc | Sclerotherapy catheter with lumen having wire rotated by motor and simultaneous withdrawal from vein |
US10076272B2 (en) | 2011-04-26 | 2018-09-18 | Velano Vascular, Inc. | Systems and methods for phlebotomy through a peripheral IV catheter |
US8366685B2 (en) * | 2011-04-26 | 2013-02-05 | Creative Vascular, Llc | Systems and methods for phlebotomy through a peripheral IV catheter |
US11458290B2 (en) | 2011-05-11 | 2022-10-04 | Ekos Corporation | Ultrasound system |
US8888692B1 (en) | 2011-08-26 | 2014-11-18 | Applied Medical Resources Corporation | Trocar cannula assembly and method of manufacture |
EP2811939B8 (en) | 2012-02-10 | 2017-11-15 | CVDevices, LLC | Products made of biological tissues for stents and methods of manufacturing |
JP2015128457A (en) * | 2012-04-27 | 2015-07-16 | テルモ株式会社 | embolus discharge catheter |
JP5508479B2 (en) * | 2012-07-05 | 2014-05-28 | 寛治 井上 | Catheter-type therapeutic / diagnostic instrument with stylet and catheter tube using stylet |
US20140121646A1 (en) * | 2012-10-29 | 2014-05-01 | FABtec Medical, Inc. | Nutrient Absorption Barrier And Delivery Method |
US20140228937A1 (en) | 2013-02-11 | 2014-08-14 | Joshua Krieger | Expandable Support Frame and Medical Device |
KR102206435B1 (en) | 2013-03-15 | 2021-01-22 | 어플라이드 메디컬 리소시스 코포레이션 | Trocar cannula assembly with low profile insertion configuration and method of manufacture |
WO2014197362A1 (en) | 2013-06-03 | 2014-12-11 | Ramtin Agah | Devices, methods and kits for delivery of therapeutic materials to a pancreas |
US20150038902A1 (en) * | 2013-08-05 | 2015-02-05 | Nico Corporation | Infusion therapy device |
EP2978381B1 (en) * | 2014-04-23 | 2019-01-16 | Gyrus ACMI, Inc. (d.b.a.Olympus Surgical Technologies America) | Stone fragment suction device |
US10661061B2 (en) * | 2014-09-08 | 2020-05-26 | Sanovas Intellectual Property, Llc | Clearance of sinus ostia blockage |
US10092742B2 (en) | 2014-09-22 | 2018-10-09 | Ekos Corporation | Catheter system |
WO2016160712A1 (en) * | 2015-04-01 | 2016-10-06 | Boston Scientific Scimed, Inc. | Pulmonary biopsy devices |
EP3307388B1 (en) | 2015-06-10 | 2022-06-22 | Ekos Corporation | Ultrasound catheter |
FR3052075B1 (en) | 2016-06-01 | 2022-01-07 | Hexacath | INFUSION CATHETER DEVICE FOR TREATING AT LEAST PARTIAL OR COMPLETE OBSTRUCTION IN A DUCT, SUCH AS BODY DUCT |
EP3551273A1 (en) * | 2016-12-08 | 2019-10-16 | Sanford Health | Slide guide catheter and methods for use thereof |
CN110430914B (en) | 2017-03-21 | 2022-03-01 | 威蓝诺血管股份有限公司 | Device for fluid delivery through a placed peripheral venous catheter |
EP3600514B1 (en) | 2017-03-21 | 2022-06-08 | Velano Vascular, Inc. | Systems and methods for controlling catheter device size |
US11052224B2 (en) | 2017-05-18 | 2021-07-06 | Renovorx, Inc. | Methods for treating cancerous tumors |
US10695543B2 (en) | 2017-05-18 | 2020-06-30 | Renovorx, Inc. | Methods for treating cancerous tumors |
US10201689B1 (en) * | 2017-08-07 | 2019-02-12 | Advanced Dilation Strategies, LLC | Urethral balloon dilator catheter |
US20190105474A1 (en) * | 2017-10-08 | 2019-04-11 | Sheibley Medical LLC | Drainage catheter with balloon |
JPWO2019131158A1 (en) * | 2017-12-27 | 2020-12-24 | 株式会社カネカ | Catheter and its manufacturing method |
MX2022002125A (en) | 2019-08-20 | 2022-06-02 | Velano Vascular Inc | Fluid transfer devices with extended length catheters and methods of using the same. |
US11696793B2 (en) | 2021-03-19 | 2023-07-11 | Crossfire Medical Inc | Vascular ablation |
CN115463322B (en) * | 2022-09-27 | 2023-11-28 | 广东博迈医疗科技股份有限公司 | Medicine saccule catheter |
US11911581B1 (en) | 2022-11-04 | 2024-02-27 | Controlled Delivery Systems, Inc. | Catheters and related methods for the aspiration controlled delivery of closure agents |
Family Cites Families (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3948254A (en) * | 1971-11-08 | 1976-04-06 | Alza Corporation | Novel drug delivery device |
US4198981A (en) * | 1978-03-27 | 1980-04-22 | Manfred Sinnreich | Intrauterine surgical device |
US4299226A (en) * | 1979-08-08 | 1981-11-10 | Banka Vidya S | Coronary dilation method |
US4531936A (en) * | 1981-01-29 | 1985-07-30 | Gordon Robert T | Device and method for the selective delivery of drugs to the myocardium |
DE3235974A1 (en) * | 1981-11-24 | 1983-06-01 | Volkmar Dipl.-Ing. Merkel (FH), 8520 Erlangen | DEVICE FOR REMOVAL OR FOR THE EXPANSION OF CONSTRAINTS IN BODY LIQUID LEADING VESSELS |
US4417576A (en) * | 1982-02-25 | 1983-11-29 | Baran Ostap E | Double-wall surgical cuff |
US4423725A (en) * | 1982-03-31 | 1984-01-03 | Baran Ostap E | Multiple surgical cuff |
US4636195A (en) * | 1982-04-02 | 1987-01-13 | Harvey Wolinsky | Method and apparatus for removing arterial constriction |
US4445892A (en) * | 1982-05-06 | 1984-05-01 | Laserscope, Inc. | Dual balloon catheter device |
US4464176A (en) * | 1982-06-04 | 1984-08-07 | Mallinckrodt, Inc. | Blood vessel catheter for medicine delivery and method of manufacture |
US4799479A (en) * | 1984-10-24 | 1989-01-24 | The Beth Israel Hospital Association | Method and apparatus for angioplasty |
US5019075A (en) * | 1984-10-24 | 1991-05-28 | The Beth Israel Hospital | Method and apparatus for angioplasty |
WO1986005990A1 (en) * | 1985-04-09 | 1986-10-23 | Harvey Wolinsky | Method for the prevention of restenosis |
US4824436A (en) * | 1985-04-09 | 1989-04-25 | Harvey Wolinsky | Method for the prevention of restenosis |
US4708718A (en) * | 1985-07-02 | 1987-11-24 | Target Therapeutics | Hyperthermic treatment of tumors |
US4705709A (en) * | 1985-09-25 | 1987-11-10 | Sherwood Medical Company | Lubricant composition, method of coating and a coated intubation device |
US4655746A (en) * | 1985-12-02 | 1987-04-07 | Target Therapeutics | Catheter device |
JPS62236560A (en) * | 1986-04-09 | 1987-10-16 | テルモ株式会社 | Catheter for repairing blood vessel |
IT8629545V0 (en) * | 1986-06-12 | 1986-06-12 | Fina Ernesto | SET BALLOON URETERAL CATHETER BALLOON FOR EXTRACTION OF URETERAL STONES |
JPH01171571A (en) * | 1987-12-28 | 1989-07-06 | Yoshiharu Yamawaki | Balloon catheter |
DE8904026U1 (en) * | 1988-04-20 | 1989-05-24 | Schneider (Europe) Ag, Zuerich, Ch | |
JPH0255064A (en) * | 1988-08-03 | 1990-02-23 | Toa O | Skin removal for throm bus in blood vessel using catheter and throm bus removing system in blood vessel using catheter |
US4968307A (en) * | 1989-01-09 | 1990-11-06 | Advanced Cardiovascular Systems, Inc. | Catheter for uniform distribution of therapeutic fluids |
US4927418A (en) * | 1989-01-09 | 1990-05-22 | Advanced Cardiovascular Systems, Inc. | Catheter for uniform distribution of therapeutic fluids |
US5021044A (en) * | 1989-01-30 | 1991-06-04 | Advanced Cardiovascular Systems, Inc. | Catheter for even distribution of therapeutic fluids |
US5087244A (en) * | 1989-01-31 | 1992-02-11 | C. R. Bard, Inc. | Catheter and method for locally applying medication to the wall of a blood vessel or other body lumen |
ES2078936T3 (en) * | 1989-01-31 | 1996-01-01 | Bard Inc C R | CATHETER AND METHOD FOR LOCALLY APPLYING MEDICATION TO THE WALL OF A BLOOD VESSEL OR ANOTHER BODY LUMEN. |
DE3915289A1 (en) * | 1989-05-10 | 1990-11-15 | Josef Dieter Dr Med Nagel | Treatment of disorders of alimentary canal - by injection of therapeutic medium into zone sealed by inflatable balloons |
US4994033A (en) * | 1989-05-25 | 1991-02-19 | Schneider (Usa) Inc. | Intravascular drug delivery dilatation catheter |
US5242397A (en) * | 1989-06-20 | 1993-09-07 | Cedars-Sinai Medical Center | Catheter device and method of use for intramural delivery of protein kinase C and tyrosine protein kinase inhibitors to prevent restenosis after balloon angioplasty |
HU212760B (en) * | 1989-06-20 | 1997-02-28 | Denes | Method and device for the apportion of chemical materials into the vein wall |
US4968306A (en) * | 1989-07-07 | 1990-11-06 | Advanced Cardiovascular Systems, Inc. | Intravascular catheter having an adjustable length infusion section to delivery therapeutic fluid |
US5049132A (en) * | 1990-01-08 | 1991-09-17 | Cordis Corporation | Balloon catheter for delivering therapeutic agents |
US5176638A (en) * | 1990-01-12 | 1993-01-05 | Don Michael T Anthony | Regional perfusion catheter with improved drug delivery control |
US5222941A (en) * | 1990-01-12 | 1993-06-29 | Don Michael T Anthony | Method of dissolving an obstruction in a vessel |
US5090960A (en) * | 1990-01-12 | 1992-02-25 | Don Michael T Anthony | Regional perfusion dissolution catheter |
US5163905A (en) * | 1990-01-12 | 1992-11-17 | Don Michael T Anthony | Regional perfusion dissolution catheter |
US5236413B1 (en) * | 1990-05-07 | 1996-06-18 | Andrew J Feiring | Method and apparatus for inducing the permeation of medication into internal tissue |
US5135484A (en) * | 1990-05-09 | 1992-08-04 | Pioneering Technologies, Inc. | Method of removing plaque from vessels |
US5092841A (en) * | 1990-05-17 | 1992-03-03 | Wayne State University | Method for treating an arterial wall injured during angioplasty |
US5199951A (en) * | 1990-05-17 | 1993-04-06 | Wayne State University | Method of drug application in a transporting medium to an arterial wall injured during angioplasty |
CA2022019C (en) * | 1990-07-26 | 1992-12-29 | Michael Black | Catheter |
US5180366A (en) * | 1990-10-10 | 1993-01-19 | Woods W T | Apparatus and method for angioplasty and for preventing re-stenosis |
EP0565604B1 (en) * | 1990-12-28 | 1999-07-28 | Boston Scientific Corporation | Catheter for drug delivery system |
WO1992011895A1 (en) * | 1990-12-28 | 1992-07-23 | Boston Scientific Corporation | Balloon drug delivery system |
US5102402A (en) * | 1991-01-04 | 1992-04-07 | Medtronic, Inc. | Releasable coatings on balloon catheters |
EP0581866B1 (en) * | 1991-04-24 | 1998-03-04 | Baxter International Inc. | Exchangeable integrated-wire balloon catheter |
US5213576A (en) * | 1991-06-11 | 1993-05-25 | Cordis Corporation | Therapeutic porous balloon catheter |
CA2074304C (en) * | 1991-08-02 | 1996-11-26 | Cyril J. Schweich, Jr. | Drug delivery catheter |
US5267959A (en) * | 1991-11-29 | 1993-12-07 | Schneider, Inc. | Laser bonding of angioplasty balloon catheters |
US5236424A (en) * | 1992-06-05 | 1993-08-17 | Cardiac Pathways Corporation | Catheter with retractable cannula for delivering a plurality of chemicals |
US5314409A (en) * | 1993-03-11 | 1994-05-24 | Uva Patents Foundation | Catheter for esophageal perfusion |
-
1994
- 1994-04-13 US US08/227,254 patent/US5415636A/en not_active Expired - Lifetime
-
1995
- 1995-01-23 WO PCT/IB1995/000052 patent/WO1995028196A1/en not_active Application Discontinuation
- 1995-01-23 AU AU13914/95A patent/AU699000B2/en not_active Ceased
- 1995-01-23 EP EP95905222A patent/EP0755279A1/en not_active Withdrawn
- 1995-01-23 CA CA002186493A patent/CA2186493C/en not_active Expired - Fee Related
- 1995-01-23 JP JP7526828A patent/JP2930422B2/en not_active Expired - Fee Related
-
1997
- 1997-08-04 US US08/905,873 patent/US5772632A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0755279A1 (en) | 1997-01-29 |
AU1391495A (en) | 1995-11-10 |
US5415636A (en) | 1995-05-16 |
JP2930422B2 (en) | 1999-08-03 |
CA2186493A1 (en) | 1995-10-26 |
US5772632A (en) | 1998-06-30 |
JPH09505503A (en) | 1997-06-03 |
AU699000B2 (en) | 1998-11-19 |
WO1995028196A1 (en) | 1995-10-26 |
MX9604820A (en) | 1998-05-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2186493C (en) | A dilation-drug delivery catheter | |
CA2195214C (en) | Drug delivery and dilation-drug delivery catheters in a rapid exchange configuration | |
EP0920882A2 (en) | Balloon dilatation-drug delivery catheter and stent deployment-drug delivery catheter in rapid exchange configuration | |
EP1351738B1 (en) | Drug delivery catheter having a highly compliant balloon with infusion holes | |
JP5061614B2 (en) | catheter | |
US8317747B2 (en) | Catheter for tissue dilation and drug delivery | |
US5728067A (en) | Rapidly exchangeable coronary catheter | |
US5195971A (en) | Perfusion type dilatation catheter | |
EP0378178B1 (en) | Catheter for uniform distribution of therapeutic fluids | |
US5611775A (en) | Method of delivery therapeutic or diagnostic liquid into tissue surrounding a body lumen | |
US6837870B2 (en) | Catheter having a multilayered shaft section with a reinforcing mandrel | |
US20070142819A1 (en) | Bifurcated catheter for agent delivery and method of agent delivery | |
WO2003075996A1 (en) | Balloon catheter for tentative vaso-occlusion | |
JP4833039B2 (en) | catheter | |
US20030163118A1 (en) | Catheter having a tapered distal tip and method of making | |
JP2003102841A (en) | Balloon catheter | |
AU720826B2 (en) | Drug delivery and dilatation-drug delivery catheters in a rapid exchange configuration | |
CA2247544C (en) | Infusion balloon catheter | |
MXPA96004820A (en) | A catheter for the release of farmaco pordilatac |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |