CA2178487A1 - Local delivery of fibrinolysis enhancing agents - Google Patents

Local delivery of fibrinolysis enhancing agents

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Publication number
CA2178487A1
CA2178487A1 CA002178487A CA2178487A CA2178487A1 CA 2178487 A1 CA2178487 A1 CA 2178487A1 CA 002178487 A CA002178487 A CA 002178487A CA 2178487 A CA2178487 A CA 2178487A CA 2178487 A1 CA2178487 A1 CA 2178487A1
Authority
CA
Canada
Prior art keywords
matrix
enhancing agents
ancrod
tpa
urokinase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002178487A
Other languages
French (fr)
Other versions
CA2178487C (en
Inventor
Randall C. Dunn
Jeffrey A. Hubbell
Jennifer L. Hill-West
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Original Assignee
Randall C. Dunn
Jeffrey A. Hubbell
Jennifer L. Hill-West
Board Of Regents, The University Of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Randall C. Dunn, Jeffrey A. Hubbell, Jennifer L. Hill-West, Board Of Regents, The University Of Texas System filed Critical Randall C. Dunn
Publication of CA2178487A1 publication Critical patent/CA2178487A1/en
Application granted granted Critical
Publication of CA2178487C publication Critical patent/CA2178487C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C12N2533/74—Alginate

Abstract

A method of preventing adhesions by topical administration of fibrinolysis enhancing agents is described. The method uses a topically applied polymeric matrix for delivery of a fibrinolytic agent, preferably urokinase, tPA, hirudin, or most preferably, ancrod. In the most preferred embodiment, the matrix is extremely thin and is polymerized in suti to form a biodegradable polymeric matrix. The matrix provides controlled release of the agent over a period of time effective to prevent surgical adhesions and is biodegradable, usually within the same time frame. Examples demonstrate that the combination of the matrix and the urokinase, tPA, birudin, or ancrod is effective in preventing surgical adhesions.
CA002178487A 1993-12-10 1994-12-09 Local delivery of fibrinolysis enhancing agents Expired - Lifetime CA2178487C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/165,392 US5468505A (en) 1992-02-28 1993-12-10 Local delivery of fibrinolysis enhancing agents
US165,392 1993-12-10
PCT/US1994/014213 WO1995015747A1 (en) 1993-12-10 1994-12-09 Local delivery of fibrinolysis enhancing agents

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CA2178487A1 true CA2178487A1 (en) 1995-06-15
CA2178487C CA2178487C (en) 2001-08-28

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EP (1) EP0732915B1 (en)
JP (2) JPH09509401A (en)
AT (1) ATE195250T1 (en)
AU (1) AU690949B2 (en)
CA (1) CA2178487C (en)
DE (1) DE69425509T2 (en)
ES (1) ES2151952T3 (en)
WO (1) WO1995015747A1 (en)

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WO1995015747A1 (en) 1995-06-15
DE69425509T2 (en) 2001-04-19
JP2006193535A (en) 2006-07-27
EP0732915A1 (en) 1996-09-25
ES2151952T3 (en) 2001-01-16
AU690949B2 (en) 1998-05-07
AU1338195A (en) 1995-06-27
US5468505A (en) 1995-11-21
DE69425509D1 (en) 2000-09-14
ATE195250T1 (en) 2000-08-15
JPH09509401A (en) 1997-09-22
CA2178487C (en) 2001-08-28
EP0732915B1 (en) 2000-08-09

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