CA2095010A1 - Injection needle arrangement - Google Patents

Injection needle arrangement

Info

Publication number
CA2095010A1
CA2095010A1 CA2095010A CA2095010A CA2095010A1 CA 2095010 A1 CA2095010 A1 CA 2095010A1 CA 2095010 A CA2095010 A CA 2095010A CA 2095010 A CA2095010 A CA 2095010A CA 2095010 A1 CA2095010 A1 CA 2095010A1
Authority
CA
Canada
Prior art keywords
injection needle
injection
needle
needle arrangement
sleeve
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2095010A
Other languages
French (fr)
Other versions
CA2095010C (en
Inventor
Birger Hjertman
Otto Westphal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Health AB
Original Assignee
Birger Hjertman
Otto Westphal
Kabi Pharmacia Aktiebolag
Pharmacia Aktiebolag
Pharmacia & Upjohn Aktiebolag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Birger Hjertman, Otto Westphal, Kabi Pharmacia Aktiebolag, Pharmacia Aktiebolag, Pharmacia & Upjohn Aktiebolag filed Critical Birger Hjertman
Publication of CA2095010A1 publication Critical patent/CA2095010A1/en
Application granted granted Critical
Publication of CA2095010C publication Critical patent/CA2095010C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A61M5/326—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
    • A61M2005/3267—Biased sleeves where the needle is uncovered by insertion of the needle into a patient's body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A61M5/326—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Catching Or Destruction (AREA)
  • Chemical Or Physical Treatment Of Fibers (AREA)
  • Polarising Elements (AREA)
  • Injection Moulding Of Plastics Or The Like (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

A device for limiting the penetration of an injection needle when an injection is administered from an injection apparatus comprises an exterior sleeve (1) arranged around the front part of the injection apparatus (2). In its foremost position, the sleeve (1) surrounds the needle (8) completely, and it may be displaced rearwards while overcoming a spring force (6), to expose the needle (8).
CA002095010A 1991-09-13 1992-08-31 Injection needle arrangement Expired - Lifetime CA2095010C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9102652A SE9102652D0 (en) 1991-09-13 1991-09-13 INJECTION NEEDLE ARRANGEMENT
SE9102652-6 1991-09-13

Publications (2)

Publication Number Publication Date
CA2095010A1 true CA2095010A1 (en) 1993-03-14
CA2095010C CA2095010C (en) 1998-02-10

Family

ID=20383716

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002095010A Expired - Lifetime CA2095010C (en) 1991-09-13 1992-08-31 Injection needle arrangement

Country Status (15)

Country Link
US (1) US5417662A (en)
EP (1) EP0557507B1 (en)
JP (1) JPH0763507B2 (en)
AT (1) ATE146977T1 (en)
AU (1) AU650785B2 (en)
CA (1) CA2095010C (en)
DE (2) DE557507T1 (en)
DK (1) DK0557507T3 (en)
ES (1) ES2041634T3 (en)
FI (1) FI113841B (en)
GR (1) GR930300111T1 (en)
NO (1) NO305638B1 (en)
SE (1) SE9102652D0 (en)
UA (1) UA27787C2 (en)
WO (1) WO1993005835A1 (en)

Families Citing this family (378)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2171563A1 (en) * 1993-09-14 1995-03-23 Eric Le Cheminant Injection device
CA2551185C (en) * 1994-03-28 2007-10-30 Sdgi Holdings, Inc. Apparatus and method for anterior spinal stabilization
SE9403433D0 (en) 1994-10-10 1994-10-10 Pharmacia Ab Injection device
SE9502285D0 (en) * 1995-06-22 1995-06-22 Pharmacia Ab Improvements related to injections
US6058321A (en) * 1995-09-07 2000-05-02 Swayze; Claude R. Instrument for continuously monitoring fetal heart rate and intermittently monitoring fetal blood pH and method of use
US6086567A (en) * 1996-04-02 2000-07-11 Disetronic Licensing Ag Injection device
DE59609696D1 (en) 1996-04-02 2002-10-24 Disetronic Licensing Ag INJECTION DEVICE
WO1998001172A1 (en) * 1996-07-05 1998-01-15 Disetronic Licensing Ag Injection device for injection of liquid
DE59610766D1 (en) 1996-07-05 2003-11-13 Disetronic Licensing Ag INJECTION DEVICE FOR INJECTING LIQUID
DE19717107B4 (en) 1997-04-23 2005-06-23 Disetronic Licensing Ag System of container and drive device for a piston, which is held in the container containing a drug fluid
CN101031143B (en) 1997-04-24 2011-10-26 株式会社Ntt都科摩 Method and system for mobile communications
DE19740187C1 (en) * 1997-09-12 1999-04-15 Disetronic Licensing Ag Dosing unit, e.g. for medicines
US6605058B1 (en) 1997-11-17 2003-08-12 Disetronic Licensing Ag Device for introducing a needle
ATE265873T1 (en) 1997-11-19 2004-05-15 B D Medico S A R L NEEDLE ARRANGEMENT
US6482176B1 (en) 1997-11-27 2002-11-19 Disetronic Licensing Ag Method and device for controlling the introduction depth of an injection needle
DE19755125B4 (en) * 1997-12-11 2006-04-20 Tecpharma Licensing Ag Needle protection device for injection devices
PT1047343E (en) 1998-01-12 2004-11-30 Alsensa Aps INJECTION UNIT
US6949111B2 (en) 1998-02-13 2005-09-27 Steven Schraga Lancet device
US5997509A (en) 1998-03-06 1999-12-07 Cornell Research Foundation, Inc. Minimally invasive gene therapy delivery device and method
CA2229522A1 (en) 1998-04-15 1999-10-15 Thomas Randall Inkpen Needle aid
DE19822031C2 (en) 1998-05-15 2000-03-23 Disetronic Licensing Ag Auto injection device
US6290679B1 (en) 1999-05-14 2001-09-18 Disetronic Licensing Ag Device for metered administration of an injectable product
DE19821933C1 (en) 1998-05-15 1999-11-11 Disetronic Licensing Ag Device for administering an injectable product
US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
DE19925904C1 (en) 1999-06-07 2001-02-01 Disetronic Licensing Ag Unit for subcutaneous application of an injectable product comprises a system which indicates whether the protection sleeve of the injection needle is in its fully retracted position
US6494865B1 (en) * 1999-10-14 2002-12-17 Becton Dickinson And Company Intradermal delivery device including a needle assembly
US20020193740A1 (en) 1999-10-14 2002-12-19 Alchas Paul G. Method of intradermally injecting substances
US6843781B2 (en) 1999-10-14 2005-01-18 Becton, Dickinson And Company Intradermal needle
US20020156453A1 (en) * 1999-10-14 2002-10-24 Pettis Ronald J. Method and device for reducing therapeutic dosage
US6569143B2 (en) 1999-10-14 2003-05-27 Becton, Dickinson And Company Method of intradermally injecting substances
US7241275B2 (en) * 1999-10-14 2007-07-10 Becton, Dickinson And Company Intradermal needle
US8465468B1 (en) 2000-06-29 2013-06-18 Becton, Dickinson And Company Intradermal delivery of substances
US6569123B2 (en) 1999-10-14 2003-05-27 Becton, Dickinson And Company Prefillable intradermal injector
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US6776776B2 (en) * 1999-10-14 2004-08-17 Becton, Dickinson And Company Prefillable intradermal delivery device
US20050070945A1 (en) * 1999-11-02 2005-03-31 Steven Schraga Single use lancet assembly
US8814896B2 (en) 1999-11-02 2014-08-26 Stat Medical Devices, Inc. Single use lancet assembly
US6322575B1 (en) 2000-01-05 2001-11-27 Steven Schraga Lancet depth adjustment assembly
DE20006251U1 (en) * 2000-04-05 2001-08-16 B D Medico Gmbh Mies Needle guard assembly
US6508802B1 (en) 2000-05-23 2003-01-21 Cornell Research Foundation, Inc. Remote sensing gene therapy delivery device and method of administering a therapeutic solution to a heart
US6547764B2 (en) 2000-05-31 2003-04-15 Novo Nordisk A/S Double pointed injection needle
US20050008683A1 (en) * 2000-06-29 2005-01-13 Becton Dickinson And Company Method for delivering interferons to the intradermal compartment
US20040175360A1 (en) * 2000-06-29 2004-09-09 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
AU2001280762A1 (en) 2000-08-02 2002-02-13 Becton, Dickinson And Company Pen needle and safety shield system
US6986760B2 (en) * 2000-08-02 2006-01-17 Becton, Dickinson And Company Pen needle and safety shield system
DE10044383C2 (en) * 2000-09-08 2003-02-06 Disetronic Licensing Ag Needle protector
DE60239594D1 (en) 2001-02-23 2011-05-12 Glaxosmithkline Biolog Sa INFLUENZA VACCINE COMPOSITIONS FOR INTRADERMAL ADMINISTRATION
AR032575A1 (en) * 2001-02-23 2003-11-12 Smithkline Beecham Biolog USE OF AN ANTIGEN FLU PREPARATION FOR THE MANUFACTURE OF AN INTRADERMIC VACCINE OF THE FLU AND PHARMACEUTICAL CASE THAT INCLUDES SUCH VACCINE
AU2002248537B2 (en) 2001-03-27 2006-07-13 Eli Lilly And Company Kit including side firing syringe needle for preparing a drug in an injection pen cartridge
GB0109297D0 (en) 2001-04-12 2001-05-30 Glaxosmithkline Biolog Sa Vaccine
EP1381423A1 (en) * 2001-04-13 2004-01-21 Becton, Dickinson and Company Methods and devices for administration of substances into the intradermal layer of skin for systemic absorption
WO2002083205A1 (en) * 2001-04-13 2002-10-24 Becton Dickinson And Company, Inc. Prefillable intradermal delivery device with hidden needle and passive shielding
EP1381344A4 (en) * 2001-04-27 2008-06-11 Glaxosmithkline Biolog Sa Novel vaccine
TWI228420B (en) 2001-05-30 2005-03-01 Smithkline Beecham Pharma Gmbh Novel vaccine composition
US20100221284A1 (en) 2001-05-30 2010-09-02 Saech-Sisches Serumwerk Dresden Novel vaccine composition
CA2450711C (en) 2001-06-13 2010-11-02 Steven Schraga Single use lancet device
US20030073609A1 (en) * 2001-06-29 2003-04-17 Pinkerton Thomas C. Enhanced pharmacokinetic profile of intradermally delivered substances
US20060018877A1 (en) * 2001-06-29 2006-01-26 Mikszta John A Intradermal delivery of vacccines and therapeutic agents
CN1253220C (en) * 2001-06-29 2006-04-26 贝克顿迪肯森公司 Intradermal delivery of vaccines and gene therapeutic agents via microcannula
US20050010193A1 (en) * 2002-05-06 2005-01-13 Laurent Philippe E. Novel methods for administration of drugs and devices useful thereof
US8048097B2 (en) * 2001-08-14 2011-11-01 Steven Schraga Single use lancet assembly
US6918918B1 (en) 2001-08-14 2005-07-19 Steven Schraga Single use lancet assembly
US20040120964A1 (en) * 2001-10-29 2004-06-24 Mikszta John A. Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses
DE60230933D1 (en) * 2001-11-30 2009-03-05 Novo Nordisk As A safety needle assembly
US20050033230A1 (en) * 2002-02-15 2005-02-10 Alchas Paul G. Prefillable intradermal delivery device with hidden needle and passive shielding
DE10207276A1 (en) * 2002-02-21 2003-09-11 Disetronic Licensing Ag Needle insertion device with a transversely movable holding element
CH695758A5 (en) * 2002-03-05 2006-08-31 Tecpharma Licensing Ag Cooler for injection devices.
US8715309B2 (en) 2002-04-29 2014-05-06 Steven Schraga Lancet device
US20040039407A1 (en) * 2002-04-29 2004-02-26 Steven Schraga Lancet device
US20060264886A9 (en) * 2002-05-06 2006-11-23 Pettis Ronald J Method for altering insulin pharmacokinetics
WO2003094995A1 (en) 2002-05-06 2003-11-20 Becton, Dickinson And Company Method and device for controlling drug pharmacokinetics
BR0313890A (en) * 2002-08-30 2005-07-26 Becton Dickinson Co Pharmacokinetic control method of immunomodulatory compounds
EP1596910B1 (en) 2003-01-30 2016-10-19 Becton Dickinson and Company Intradermal delivery device with contoured skin engaging surface geometry
AU2004272972A1 (en) 2003-05-22 2005-03-24 Fraunhofer Usa, Inc. Recombinant carrier molecule for expression, delivery and purification of target polypeptides
CA2529048A1 (en) * 2003-06-13 2005-02-24 Becton, Dickinson And Company Improved intra-dermal delivery of biologically active agents
US8932264B2 (en) * 2003-08-11 2015-01-13 Becton, Dickinson And Company Medication delivery pen assembly with needle locking safety shield
JP3100042U (en) * 2003-08-26 2004-04-30 アルプス電気株式会社 Television tuner
WO2005023328A2 (en) * 2003-08-26 2005-03-17 Becton Dickinson And Company Methods for intradermal delivery of therapeutics agents
US20070185460A1 (en) 2003-08-28 2007-08-09 Lionel Vedrine Intradermal injection device
WO2005034949A1 (en) * 2003-09-09 2005-04-21 University Of Florida Desferrithiocin derivatives and their use as iron chelators
FR2861284B1 (en) * 2003-10-24 2005-12-30 Gaetan Terrasse THERAPEUTIC AND DIAGNOSTIC INOCULATION DEVICE
US20050256499A1 (en) * 2004-03-03 2005-11-17 Pettis Ronald J Methods and devices for improving delivery of a substance to skin
EP1744784A2 (en) * 2004-05-11 2007-01-24 Becton, Dickinson and Company Formulations of anti-pain agents and methods of using the same
WO2007001448A2 (en) 2004-11-04 2007-01-04 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
US20060178686A1 (en) * 2005-02-07 2006-08-10 Steven Schraga Single use lancet device
PE20061428A1 (en) 2005-03-23 2007-01-16 Glaxosmithkline Biolog Sa VACCINE FORMULATION INCLUDING AN OIL EMULSION ADJUVANT IN WATER AND 3D-MPL
ES2732625T3 (en) 2005-04-04 2019-11-25 Univ Florida Desferritiocin polyether analogs
EP1919504B1 (en) * 2005-08-03 2013-10-16 iBio, Inc. Antibody to bacillus anthracis protective antigen
TWI457133B (en) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa Novel composition
WO2007070682A2 (en) * 2005-12-15 2007-06-21 Massachusetts Institute Of Technology System for screening particles
US8277816B2 (en) * 2006-02-13 2012-10-02 Fraunhofer Usa, Inc. Bacillus anthracis antigens, vaccine compositions, and related methods
JP2009526526A (en) * 2006-02-13 2009-07-23 フラウンホーファー ユーエスエー， インコーポレイテッド Influenza antigens, vaccine compositions, and related methods
US20080279877A1 (en) * 2006-02-13 2008-11-13 Fraunhofer U.S.A. Inc. HPV antigens, vaccine compositions, and related methods
EP1998684A4 (en) * 2006-03-10 2014-09-17 Massachusetts Inst Technology Triggered self-assembly conjugates and nanosystems
US7666912B2 (en) 2006-03-23 2010-02-23 Massachusetts Eye And Ear Infirmary Compositions and methods for reducing body fat
ES2776100T3 (en) 2006-03-31 2020-07-29 Massachusetts Inst Technology System for targeted delivery of therapeutic agents
WO2007120638A2 (en) * 2006-04-12 2007-10-25 President And Fellows Of Harvard College Methods and compositions for modulating glycosylation
WO2007133807A2 (en) 2006-05-15 2007-11-22 Massachusetts Institute Of Technology Polymers for functional particles
WO2007143574A1 (en) * 2006-06-02 2007-12-13 President And Fellows Of Harvard College Protein surface remodeling
US9381477B2 (en) 2006-06-23 2016-07-05 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
SI2422810T1 (en) 2006-07-17 2015-01-30 Glaxosmithkline Biologicals S.A. Influenza vaccine
US9115358B2 (en) * 2006-08-11 2015-08-25 President And Fellows Of Harvard College Moenomycin biosynthesis-related compositions and methods of use thereof
US20090269342A1 (en) * 2006-08-14 2009-10-29 Massachusetts Institute Of Technology Hemagglutinin Polypeptides, and Reagents and Methods Relating Thereto
KR20090050056A (en) * 2006-08-14 2009-05-19 메사츄세츠 인스티튜트 어브 테크놀로지 Hemagglutinin polypeptides, and reagents and methods
JO3598B1 (en) 2006-10-10 2020-07-05 Infinity Discovery Inc Boronic acids and esters as inhibitors of fatty acid amide hydrolase
US7811254B2 (en) * 2006-10-18 2010-10-12 Meridian Medical Technologies, Inc. Autoinjector with needle depth adapter
CN101848702B (en) 2006-12-01 2013-07-17 安特里奥公司 Amphiphilic entity nanoparticles
WO2008073856A2 (en) * 2006-12-08 2008-06-19 Massachusetts Institute Of Technology Delivery of nanoparticles and/or agents to cells
CN110003079A (en) 2006-12-26 2019-07-12 兰休斯医疗成像公司 For making the ligand of imaging cardiac innervation
AU2008210434C8 (en) 2007-01-31 2014-03-27 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
US9217129B2 (en) * 2007-02-09 2015-12-22 Massachusetts Institute Of Technology Oscillating cell culture bioreactor
AU2008229472B2 (en) 2007-03-15 2013-03-14 University Of Florida Research Foundation, Inc. Desferrithiocin polyether analogues
US7960139B2 (en) 2007-03-23 2011-06-14 Academia Sinica Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells
BRPI0809366B8 (en) 2007-03-28 2021-05-25 Harvard College substantially alpha-helical polypeptide, method for manufacturing same, amino acid and pharmaceutical composition
JP2010523595A (en) 2007-04-04 2010-07-15 マサチューセッツ インスティテュート オブ テクノロジー Poly (amino acid) targeting part
WO2008124634A1 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Polymer-encapsulated reverse micelles
WO2008134643A2 (en) * 2007-04-28 2008-11-06 Fraunhofer Usa, Inc. Trypanosoma antigens, vaccine compositions, and related methods
CN101754770B (en) * 2007-06-14 2015-05-20 克鲁塞尔瑞士股份公司 Intradermal influenza vaccine
WO2008156676A1 (en) 2007-06-15 2008-12-24 President And Fellows Of Harvard College Methods and compositions for detecting and modulating o-glycosylation
WO2009009759A2 (en) 2007-07-11 2009-01-15 Fraunhofer Usa, Inc. Yersinia pestis antigens, vaccine compositions, and related methods
US20110059130A1 (en) * 2007-08-20 2011-03-10 Fraunhofer Usa, Inc. Prophylactic and therapeutic influenza vaccines, antigens, compositions and methods
WO2009046314A2 (en) * 2007-10-04 2009-04-09 President And Fellows Of Harvard College Moenomycin analogs, methods of synthesis, and uses thereof
US10736848B2 (en) 2007-10-12 2020-08-11 Massachusetts Institute Of Technology Vaccine nanotechnology
CN101951927A (en) * 2008-01-03 2011-01-19 麻省理工学院 Decoy influenza therapies
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
ES2733497T3 (en) 2008-03-13 2019-11-29 Becton Dickinson Co Pen needle safety set with protection for the opposite end of the patient
WO2009114762A1 (en) 2008-03-13 2009-09-17 Becton, Dickinson And Company Safety pen needle assembly having shielding for patient and non-patient ends
US9642971B2 (en) 2008-03-13 2017-05-09 Becton, Dickinson And Company Safety needle assembly
AR072249A1 (en) * 2008-04-09 2010-08-18 Infinity Pharmaceuticals Inc INHIBITORS OF AMIDA HYDROLASS ACID FAT. APPLICATIONS. METHODS
AU2009243187C1 (en) * 2008-04-28 2015-12-24 President And Fellows Of Harvard College Supercharged proteins for cell penetration
BRPI0914630A2 (en) 2008-06-26 2019-09-24 Anterios Inc dermal release
JP5986745B2 (en) 2008-07-15 2016-09-06 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ Glycan arrays on PTFE-like aluminum-coated glass slides and related methods
EP2356139A4 (en) 2008-07-23 2013-01-09 Harvard College Ligation of stapled polypeptides
AU2009274571A1 (en) * 2008-07-23 2010-01-28 Massachusetts Institute Of Technology Activation of histone deacetylase 1 (HDAC1) protects against DNA damage and increases neuronal survival
WO2010037046A1 (en) 2008-09-28 2010-04-01 Fraunhofer Usa, Inc. Humanized neuraminidase antibody and methods of use thereof
US8343497B2 (en) 2008-10-12 2013-01-01 The Brigham And Women's Hospital, Inc. Targeting of antigen presenting cells with immunonanotherapeutics
US8343498B2 (en) * 2008-10-12 2013-01-01 Massachusetts Institute Of Technology Adjuvant incorporation in immunonanotherapeutics
US8277812B2 (en) 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
US8591905B2 (en) 2008-10-12 2013-11-26 The Brigham And Women's Hospital, Inc. Nicotine immunonanotherapeutics
EP2376619A4 (en) 2008-12-15 2012-07-04 Greenlight Biosciences Inc Methods for control of flux in metabolic pathways
CN105132387A (en) * 2008-12-22 2015-12-09 绿光生物科学公司 Compositions and methods for the production of a compound
EP2416660B1 (en) 2009-04-07 2014-07-02 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
AU2010234449A1 (en) 2009-04-07 2011-11-03 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
US9221886B2 (en) 2009-04-28 2015-12-29 President And Fellows Of Harvard College Supercharged proteins for cell penetration
US8765735B2 (en) * 2009-05-18 2014-07-01 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
US8927551B2 (en) * 2009-05-18 2015-01-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
US9149465B2 (en) * 2009-05-18 2015-10-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
EP2438046A4 (en) 2009-06-01 2013-04-17 Harvard College O-glcnac transferase inhibitors and uses thereof
AU2010273220B2 (en) 2009-07-13 2015-10-15 President And Fellows Of Harvard College Bifunctional stapled polypeptides and uses thereof
CA2774973A1 (en) 2009-09-22 2011-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
EP2483307A1 (en) 2009-09-29 2012-08-08 Fraunhofer USA, Inc. Influenza hemagglutinin antibodies, compositions, and related methods
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
CA2784807C (en) 2009-12-29 2021-12-14 Dana-Farber Cancer Institute, Inc. Type ii raf kinase inhibitors
EP2528615B1 (en) 2010-01-27 2020-05-13 Massachusetts Institute of Technology Engineered polypeptide agents for targeted broad spectrum influenza neutralization
CN102834401B (en) 2010-02-03 2016-08-24 无限药品股份有限公司 Inhibitors of fatty acid amide hydrolase
CN102844023B (en) 2010-03-08 2016-01-20 索隆-基特林癌症研究协会 CDC7 inhibitors of kinases with and uses thereof
US9102697B2 (en) 2010-03-22 2015-08-11 President And Fellows Of Harvard College Trioxacarcins and uses thereof
WO2011130332A1 (en) 2010-04-12 2011-10-20 Academia Sinica Glycan arrays for high throughput screening of viruses
US8450350B2 (en) 2010-05-05 2013-05-28 Infinity Pharmaceuticals, Inc. Triazoles as inhibitors of fatty acid synthase
CA2798330A1 (en) 2010-05-05 2011-11-10 Infinity Pharmaceuticals, Inc. Tetrazolones as inhibitors of fatty acid synthase
WO2011140516A2 (en) 2010-05-07 2011-11-10 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways through enzyme relocation
BR122020018186B1 (en) 2010-05-11 2021-07-27 Lantheus Medical Imaging, Inc USE OF IMAGING AGENTS TO PREPARE A COMPOSITION FOR DETECTION OF THE NOREPINEPHRIN CONVEYOR (NET) AND METHOD FOR THE DETECTION OF NET
ES2664872T3 (en) 2010-06-18 2018-04-23 Taiho Pharmaceutical Co., Ltd PRPK-TPRKB modulators and their uses
EP2399631A1 (en) * 2010-06-28 2011-12-28 Sanofi-Aventis Deutschland GmbH Auto-injector with injection damper
EP3578205A1 (en) 2010-08-06 2019-12-11 ModernaTX, Inc. A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof
US8859723B2 (en) 2010-08-13 2014-10-14 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US8916358B2 (en) 2010-08-31 2014-12-23 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways through protease manipulation
EP2640405A4 (en) 2010-09-21 2015-04-15 Massachusetts Inst Technology Human-adapted ha polypeptides, vaccines, and influenza treatment
US8957026B2 (en) 2010-09-22 2015-02-17 President And Fellows Of Harvard College Beta-catenin targeting peptides and uses thereof
US20120237975A1 (en) 2010-10-01 2012-09-20 Jason Schrum Engineered nucleic acids and methods of use thereof
AU2011312178B2 (en) 2010-10-04 2016-05-12 Massachusetts Institute Of Technology Hemagglutinin polypeptides, and reagents and methods relating thereto
WO2012062803A1 (en) * 2010-11-09 2012-05-18 Novo Nordisk A/S Double-acylated glp-1 derivatives
CA2817577A1 (en) 2010-11-10 2012-05-18 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US8809349B2 (en) 2011-01-10 2014-08-19 Infinity Pharmaceuticals, Inc. Processes for preparing isoquinolinones and solid forms of isoquinolinones
US9089579B2 (en) 2011-01-19 2015-07-28 Topokine Therapeutics, Inc. Methods and compositions for treating metabolic syndrome
TR201905477T4 (en) 2011-01-24 2019-05-21 Anterios Inc Nano-particle compositions.
AU2012209274A1 (en) 2011-01-24 2013-09-12 Anterios, Inc. Nanoparticle compositions, formulations thereof, and uses therefor
EP2667945A1 (en) 2011-01-24 2013-12-04 Anterios, Inc. Oil compositions
CN103889219A (en) 2011-03-03 2014-06-25 特萨斯制药有限责任公司 Compositions and methods comprising c16:1n7-palmitoleate
WO2012135615A2 (en) 2011-03-30 2012-10-04 Brown University Enopeptins, uses thereof, and methods of synthesis thereto
EP2691101A2 (en) 2011-03-31 2014-02-05 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
CA2840224C (en) 2011-06-22 2019-08-13 The General Hospital Corporation Treatment of proteinopathies
AU2012284088B2 (en) 2011-07-19 2015-10-08 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
AR088218A1 (en) 2011-07-19 2014-05-21 Infinity Pharmaceuticals Inc USEFUL HETEROCICLICAL COMPOUNDS AS PI3K INHIBITORS
CA2842524C (en) 2011-07-22 2020-07-14 Massachusetts Institute Of Technology Activators of class i histone deacetylases (hdacs) and uses thereof
EP2751093A1 (en) 2011-08-29 2014-07-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CA2848147C (en) 2011-09-09 2021-08-24 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
WO2013036787A2 (en) 2011-09-09 2013-03-14 Greenlight Biosciences, Inc. Cell-free preparation of carbapenems
WO2013039861A2 (en) 2011-09-12 2013-03-21 modeRNA Therapeutics Engineered nucleic acids and methods of use thereof
WO2013049332A1 (en) 2011-09-29 2013-04-04 Infinity Pharmaceuticals, Inc. Inhibitors of monoacylglycerol lipase and methods of their use
CA2850624A1 (en) 2011-10-03 2013-04-11 Moderna Therapeutics, Inc. Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
CN108929375A (en) 2011-10-18 2018-12-04 爱勒让治疗公司 Peptidomimetic macrocyclic compound
WO2013074986A1 (en) 2011-11-17 2013-05-23 Dana-Farber Cancer Institute, Inc. Inhibitors of c-jun-n-terminal kinase (jnk)
GB201120000D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
GB201119999D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
CN113398126A (en) 2011-12-16 2021-09-17 佛罗里达大学研究基金会 Use of 4' -deferthionin analogues
KR20140102759A (en) 2011-12-16 2014-08-22 모더나 세라퓨틱스, 인코포레이티드 Modified nucleoside, nucleotide, and nucleic acid compositions
US8426471B1 (en) 2011-12-19 2013-04-23 Topokine Therapeutics, Inc. Methods and compositions for reducing body fat and adipocytes
US8987414B2 (en) 2012-02-15 2015-03-24 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
US8927500B2 (en) 2012-02-15 2015-01-06 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
WO2013152279A1 (en) 2012-04-06 2013-10-10 President And Fellows Of Harvard College Chemoenzymatic methods for synthesizing moenomycin analogs
WO2013151697A1 (en) 2012-04-06 2013-10-10 President And Fellows Of Harvard College Methods and compounds for identifying glycosyltransferase inhibitors
US9273084B2 (en) 2012-04-06 2016-03-01 President And Fellows Of Harvard College Moenomycin analogs, methods of synthesis, and uses thereof
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US10130714B2 (en) 2012-04-14 2018-11-20 Academia Sinica Enhanced anti-influenza agents conjugated with anti-inflammatory activity
US9597385B2 (en) 2012-04-23 2017-03-21 Allertein Therapeutics, Llc Nanoparticles for treatment of allergy
MX2014013678A (en) 2012-05-10 2015-02-04 Massachusetts Inst Technology Agents for influenza neutralization.
JP2015525794A (en) 2012-08-06 2015-09-07 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム Method for eliciting an immune response against RSV and Bordetella pertussis in infants
US20140037680A1 (en) 2012-08-06 2014-02-06 Glaxosmithkline Biologicals, S.A. Novel method
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
AU2013306098A1 (en) 2012-08-18 2015-02-12 Academia Sinica Cell-permeable probes for identification and imaging of sialidases
HUE054444T2 (en) 2012-09-26 2021-09-28 Harvard College Proline-locked stapled peptides and uses thereof
US20150225471A1 (en) 2012-10-01 2015-08-13 President And Fellows Of Harvard College Stabilized polypeptide insulin receptor modulators
JP6321662B2 (en) 2012-10-12 2018-05-09 ザ ブロード インスティテュート, インコーポレーテッドThe Broad Institute, Inc. GSK3 inhibitor and method of use thereof
US10112927B2 (en) 2012-10-18 2018-10-30 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (CDK7)
WO2014063061A1 (en) 2012-10-19 2014-04-24 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged small molecules as inducers of protein degradation
WO2014063054A1 (en) 2012-10-19 2014-04-24 Dana-Farber Cancer Institute, Inc. Bone marrow on x chromosome kinase (bmx) inhibitors and uses thereof
JP6526563B2 (en) 2012-11-01 2019-06-05 エイルロン セラピューティクス，インコーポレイテッド Disubstituted amino acids and methods for their preparation and use
PT2914296T (en) 2012-11-01 2018-10-30 Infinity Pharmaceuticals Inc Treatment of cancers using pi3 kinase isoform modulators
US9567301B2 (en) 2012-11-02 2017-02-14 Dana-Farber Cancer Institute, Inc. Pyrrol-1-yl benzoic acid derivatives useful as myc inhibitors
CA2869676C (en) 2012-11-21 2015-06-23 Topokine Therapeutics, Inc. Uses and compositions comprising a thiazolidinedione and oleic acid for locally increasing subcutaneous fat
JP6144355B2 (en) 2012-11-26 2017-06-07 モデルナティエックス インコーポレイテッドＭｏｄｅｒｎａＴＸ，Ｉｎｃ． Chemically modified mRNA
JP6408478B2 (en) 2012-11-26 2018-10-17 プレジデント アンド フェローズ オブ ハーバード カレッジ Trioxacalcin, trioxacalcin-antibody complex and use thereof
US8906900B2 (en) 2012-12-21 2014-12-09 Epizyme, Inc. PRMT5 inhibitors and uses thereof
WO2014100716A1 (en) 2012-12-21 2014-06-26 Epizyme, Inc. Prmt5 inhibitors and uses thereof
US8940726B2 (en) 2012-12-21 2015-01-27 Epizyme, Inc. PRMT5 inhibitors and uses thereof
JP6678455B2 (en) 2012-12-21 2020-04-08 エピザイム，インコーポレイティド PRMT5 inhibitors and uses thereof
CA2897941A1 (en) 2013-01-17 2014-07-24 Moderna Therapeutics, Inc. Signal-sensor polynucleotides for the alteration of cellular phenotypes
JP6518597B2 (en) 2013-02-07 2019-05-22 マサチューセッツ インスティテュート オブ テクノロジー Human adaptation of H5 influenza
WO2014124228A1 (en) 2013-02-07 2014-08-14 Children's Medical Center Corporation Protein antigens that provide protection against pneumococcal colonization and/or disease
KR20150131244A (en) 2013-03-13 2015-11-24 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 Stapled and stitched polypeptides and uses thereof
US20160024181A1 (en) 2013-03-13 2016-01-28 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
NZ629037A (en) 2013-03-15 2017-04-28 Infinity Pharmaceuticals Inc Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
AU2014248090B2 (en) 2013-04-03 2018-08-02 N-Fold Llc Novel nanoparticle compositions
CN111825733A (en) 2013-04-04 2020-10-27 哈佛大学的校长及成员们 Macrolides and methods of making and using the same
ES2774330T3 (en) 2013-04-09 2020-07-20 Massachusetts Inst Technology Drug supply polymer and uses thereof
WO2014179464A1 (en) 2013-04-30 2014-11-06 Massachusetts Institute Of Technology Human adaptation of h3 influenza
US9315472B2 (en) 2013-05-01 2016-04-19 Massachusetts Institute Of Technology 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof
NO2753788T3 (en) 2013-05-10 2018-06-16
DK3003309T3 (en) 2013-05-30 2020-12-14 Infinity Pharmaceuticals Inc Treatment of cancer with PI3 kinase isoform modulators
WO2014197723A2 (en) 2013-06-05 2014-12-11 Massachusetts Institute Of Technology Human adaptation of h7 ha
EP3030239A4 (en) 2013-06-11 2017-03-08 Kala Pharmaceuticals, Inc. Urea derivatives and uses thereof
CN105492460A (en) 2013-06-14 2016-04-13 哈佛大学的校长及成员们 Stabilized polypeptide insulin receptor modulators
US10086054B2 (en) 2013-06-26 2018-10-02 Academia Sinica RM2 antigens and use thereof
EP3013347B1 (en) 2013-06-27 2019-12-11 Academia Sinica Glycan conjugates and use thereof
BR112016001457A2 (en) 2013-07-25 2017-08-29 Dana Farber Cancer Inst Inc TRANSCRIPTION FACTOR INHIBITORS AND THEIR USES
BR112016002494A2 (en) 2013-08-05 2017-09-05 Greenlight Biosciences Inc PROTEINS CONSTRUCTED WITH A PROTEASE CLEAVAGE SITE, NUCLEIC ACID, VECTOR, CELL AND PROCESS ENGINEERING A RECOMBINANT PROTEIN AND A LARGE NUMBER OF NUCLEIC ACID VARIANTS THAT ENCODE RECOMBINANT PROTEINS
CA2919773A1 (en) 2013-08-05 2015-02-12 Glaxosmithkline Biologicals S.A. Combination immunogenic compositions
CN105682666B (en) 2013-09-06 2021-06-01 中央研究院 Activation of human iNKT cells using glycolipids
EP3092220B1 (en) 2013-09-25 2021-01-20 University of Florida Research Foundation, Inc. Vitamin c prodrugs and uses thereof
US9751888B2 (en) 2013-10-04 2017-09-05 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
PE20160685A1 (en) 2013-10-04 2016-07-23 Infinity Pharmaceuticals Inc HETEROCYCLIC COMPOUNDS AND USES OF THEM
US9982009B2 (en) 2013-10-15 2018-05-29 Massachusetts Institute Of Technology Methods for treating polycystic kidney disease and polycystic liver disease
WO2015057958A2 (en) 2013-10-16 2015-04-23 Massachusetts Institute Of Technology Enterobactin conjugates and uses thereof
JP6491202B2 (en) 2013-10-18 2019-03-27 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド Polycyclic inhibitors of cyclin dependent kinase 7 (CDK 7)
ES2676734T3 (en) 2013-10-18 2018-07-24 Syros Pharmaceuticals, Inc. Heteroatomic compounds useful for the treatment of proliferative diseases
US20160244452A1 (en) 2013-10-21 2016-08-25 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
JP6426194B2 (en) 2013-11-01 2018-11-21 カラ ファーマシューティカルズ インコーポレイテッド Crystalline forms of therapeutic compounds and uses thereof
CA2873681C (en) 2013-12-10 2022-05-24 Becton, Dickinson And Company Passive safety pen needle assembly
EP2883563B1 (en) 2013-12-10 2021-03-31 Becton, Dickinson and Company Active safety pen needle assembly
EA201891279A1 (en) 2013-12-24 2019-01-31 Президент Энд Феллоус Оф Гарвард Колледж ANALOGUES OF CORTISTATIN, THEIR SYNTHESIS AND APPLICATIONS
US10150818B2 (en) 2014-01-16 2018-12-11 Academia Sinica Compositions and methods for treatment and detection of cancers
US9982041B2 (en) 2014-01-16 2018-05-29 Academia Sinica Compositions and methods for treatment and detection of cancers
JP2017504651A (en) 2014-01-31 2017-02-09 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド Use of diazepan derivatives
JP6625071B2 (en) 2014-03-07 2019-12-25 ザ アリゾナ ボード オブ リージェンツ オン ビハーフ オブ ザ ユニバーシティー オブ アリゾナ Non-drug CRMP2 peptides targeting sodium channels for chronic pain
SG10201808053XA (en) 2014-03-19 2018-10-30 Infinity Pharmaceuticals Inc Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
TWI687428B (en) 2014-03-27 2020-03-11 中央研究院 Reactive labelling compounds and uses thereof
ES2868305T3 (en) 2014-03-28 2021-10-21 Univ Washington Through Its Center For Commercialization Vaccines against breast and ovarian cancer
US10017477B2 (en) 2014-04-23 2018-07-10 Dana-Farber Cancer Institute, Inc. Janus kinase inhibitors and uses thereof
US9862688B2 (en) 2014-04-23 2018-01-09 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged janus kinase inhibitors and uses thereof
WO2015168079A1 (en) 2014-04-29 2015-11-05 Infinity Pharmaceuticals, Inc. Pyrimidine or pyridine derivatives useful as pi3k inhibitors
WO2015168380A1 (en) 2014-04-30 2015-11-05 Massachusetts Institute Of Technology Siderophore-based immunization against gram-negative bacteria
CN106573032B (en) 2014-05-21 2022-03-18 哈佛大学的校长及成员们 RAS inhibitory peptides and uses thereof
CN106573971A (en) 2014-05-27 2017-04-19 中央研究院 Anti-CD20 glycoantibodies and uses thereof
EP3149161B1 (en) 2014-05-27 2021-07-28 Academia Sinica Fucosidase from bacteroides and methods using the same
AU2015267045B2 (en) 2014-05-27 2021-02-25 Academia Sinica Anti-HER2 glycoantibodies and uses thereof
US10118969B2 (en) 2014-05-27 2018-11-06 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
TWI732738B (en) 2014-05-28 2021-07-11 中央研究院 Anti-tnf-alpha glycoantibodies and uses thereof
EP3154576A1 (en) 2014-06-13 2017-04-19 GlaxoSmithKline Biologicals S.A. Immunogenic combinations
SI3157916T1 (en) 2014-06-19 2019-05-31 Ariad Pharmaceuticals, Inc. Heteroaryl compounds for kinase inhibition
US10188661B2 (en) 2014-06-27 2019-01-29 Topokine Therapeutics, Inc. Topical dosage regimen
WO2016004202A1 (en) 2014-07-02 2016-01-07 Massachusetts Institute Of Technology Polyamine-fatty acid derived lipidoids and uses thereof
EP3169699A4 (en) 2014-07-18 2018-06-20 The University of Washington Cancer vaccine compositions and methods of use thereof
US10736966B2 (en) 2014-08-12 2020-08-11 Massachusetts Institute Of Technology Brush-poly (glycoamidoamine)-lipids and uses thereof
WO2016040369A2 (en) 2014-09-08 2016-03-17 Academia Sinica HUMAN iNKT CELL ACTIVATION USING GLYCOLIPIDS
SG10201902594QA (en) 2014-09-24 2019-04-29 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof
US10905739B2 (en) 2014-09-24 2021-02-02 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and formulations thereof
US9708348B2 (en) 2014-10-03 2017-07-18 Infinity Pharmaceuticals, Inc. Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
TN2017000157A1 (en) 2014-10-21 2018-10-19 Ariad Pharma Inc Crystalline forms of 5-chloro-n4-[-2-(dimethylphosphoryl) phenyl]-n2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl) piperidin-1-yl] pyrimidine-2,4-diamine
US20180015101A1 (en) 2014-10-28 2018-01-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Compositions and methods for antigen-specific tolerance
EP3461904A1 (en) 2014-11-10 2019-04-03 ModernaTX, Inc. Alternative nucleic acid molecules containing reduced uracil content and uses thereof
US10253045B2 (en) 2014-11-26 2019-04-09 Kala Pharmaceuticals, Inc. Crystalline forms of a therapeutic compound and uses thereof
EP3230272B1 (en) 2014-12-10 2020-08-19 Kala Pharmaceuticals, Inc. 1-amino-triazolo(1,5-a)pyridine-substituted urea derivative and uses thereof
AU2015364280A1 (en) 2014-12-18 2017-07-06 Windgap Medical, Inc. Method and compositions for dissolving or solubilizing therapeutic agents
AU2015369707B2 (en) 2014-12-23 2020-07-23 Sloan-Kettering Institute For Cancer Research Polymorph of granaticin B
WO2016105528A2 (en) 2014-12-23 2016-06-30 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (cdk7)
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
US9975965B2 (en) 2015-01-16 2018-05-22 Academia Sinica Compositions and methods for treatment and detection of cancers
EP3248005B1 (en) 2015-01-24 2020-12-09 Academia Sinica Novel glycan conjugates and methods of use thereof
MX2017011834A (en) 2015-03-20 2018-04-11 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof.
CA2978518C (en) 2015-03-27 2023-11-21 Nathanael S. Gray Inhibitors of cyclin-dependent kinases
MX2017012665A (en) 2015-03-30 2018-04-24 Greenlight Biosciences Inc Cell-free production of ribonucleic acid.
US10570104B2 (en) 2015-04-27 2020-02-25 University Of Florida Research Foundation, Incorporated Metabolically programmed metal chelators and uses thereof
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
EP3307728A4 (en) 2015-06-12 2019-07-17 Dana Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors
US10201618B2 (en) 2015-06-19 2019-02-12 Massachusetts Institute Of Technology Alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof
WO2017004548A1 (en) 2015-07-01 2017-01-05 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
EP4019515A1 (en) 2015-09-09 2022-06-29 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinases
EP3347372A4 (en) 2015-09-10 2019-09-04 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of mcl-1
AU2016324310B2 (en) 2015-09-17 2021-04-08 Modernatx, Inc. Compounds and compositions for intracellular delivery of therapeutic agents
US20180256750A1 (en) 2015-09-17 2018-09-13 Moderna Therapeutics, Inc. Polynucleotides containing a stabilizing tail region
WO2017059389A1 (en) 2015-10-01 2017-04-06 Kythera Biopharmaceuticals, Inc. Compositions comprising a statin for use in methods of adipolysis
EP3369447A4 (en) * 2015-10-30 2019-06-26 Terumo Kabushiki Kaisha Grip and syringe assembly
PL3394030T3 (en) 2015-12-22 2022-04-11 Modernatx, Inc. Compounds and compositions for intracellular delivery of agents
USD806246S1 (en) 2016-02-25 2017-12-26 Steven Schraga Lancet cover
TW201808978A (en) 2016-03-08 2018-03-16 中央研究院 Methods for modular synthesis of N-glycans and arrays thereof
WO2017161116A1 (en) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
EP4293104A3 (en) 2016-04-06 2024-04-24 Greenlight Biosciences, Inc. Cell-free production of ribonucleic acid
SG10201913650WA (en) 2016-06-03 2020-03-30 Sanofi Pasteur Inc Modification of engineered influenza hemagglutinin polypeptides
US10105449B2 (en) 2016-06-07 2018-10-23 Massachusetts Institute Of Technology Drug delivery polymers and uses thereof
WO2017214269A1 (en) 2016-06-08 2017-12-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
AU2017286606A1 (en) 2016-06-14 2018-12-13 Modernatx, Inc. Stabilized formulations of lipid nanoparticles
CN109862908B (en) 2016-08-05 2023-05-02 圣诺菲·帕斯图尔公司 Multivalent pneumococcal polysaccharide-protein conjugate composition
MX2019001341A (en) 2016-08-05 2019-07-04 Sanofi Pasteur Inc Multivalent pneumococcal polysaccharide-protein conjugate composition.
JP7213549B2 (en) 2016-08-22 2023-01-27 シーエイチオー ファーマ インコーポレイテッド Antibodies, Binding Fragments, and Methods of Use
US20180085555A1 (en) * 2016-09-26 2018-03-29 Boston Scientific Scimed, Inc. Injection catheter
WO2018089540A1 (en) 2016-11-08 2018-05-17 Modernatx, Inc. Stabilized formulations of lipid nanoparticles
CN110198703A (en) 2016-11-21 2019-09-03 艾里奥治疗公司 The transdermal delivery of big reagent
WO2018106738A1 (en) 2016-12-05 2018-06-14 Massachusetts Institute Of Technology Brush-arm star polymers, conjugates and particles, and uses thereof
CA3055653A1 (en) 2017-03-15 2018-09-20 Modernatx, Inc. Lipid nanoparticle formulation
HUE060693T2 (en) 2017-03-15 2023-04-28 Modernatx Inc Compound and compositions for intracellular delivery of therapeutic agents
US11555031B2 (en) 2017-03-20 2023-01-17 The Broad Institute, Inc. Compounds and methods for regulating insulin secretion
JP7157075B2 (en) 2017-04-05 2022-10-19 ザ ブロード インスティテュート，インコーポレーテッド Tricyclic compounds and their use as glycogen synthase kinase 3 (GSK3) inhibitors
US20210198200A1 (en) 2017-06-14 2021-07-01 Modernatx, Inc. Compounds and compositions for intracellular delivery of agents
WO2019013789A1 (en) 2017-07-12 2019-01-17 Curza Global, Llc Antimicrobial compounds
WO2019013790A1 (en) 2017-07-12 2019-01-17 Curza Global, Llc Antimicrobial compounds and uses thereof
JP7275111B2 (en) 2017-08-31 2023-05-17 モデルナティエックス インコーポレイテッド Method for producing lipid nanoparticles
AU2018347405B2 (en) 2017-10-11 2022-02-03 Greenlight Biosciences, Inc. Methods and compositions for nucleoside triphosphate and ribonucleic acid production
US11786477B2 (en) 2017-12-01 2023-10-17 North Carolina State University Fibrin particles and methods of making the same
AU2019338459A1 (en) 2018-09-13 2021-04-08 Eirion Therapeutics, Inc. Plasminogen activator inhibitor 1 (PAI-1) inhibitors and uses therefor
KR20210057140A (en) 2018-09-13 2021-05-20 에이리온 테라퓨틱스, 인코포레이티드 Use of plasminogen activator inhibitor 1 (PAI-1) inhibitor
CA3113436A1 (en) 2018-09-19 2020-03-26 Modernatx, Inc. Compounds and compositions for intracellular delivery of therapeutic agents
WO2020061457A1 (en) 2018-09-20 2020-03-26 Modernatx, Inc. Preparation of lipid nanoparticles and methods of administration thereof
JP2022510007A (en) 2018-12-03 2022-01-25 エイリオン セラピューティクス， インコーポレイテッド Improved delivery of large drugs
CN113924292A (en) 2019-01-16 2022-01-11 库扎环球有限责任公司 Antimicrobial compounds and methods
CN113825748A (en) 2019-01-16 2021-12-21 库扎环球有限责任公司 Antimicrobial compounds and methods
CA3128215A1 (en) 2019-01-31 2020-08-06 Modernatx, Inc. Methods of preparing lipid nanoparticles
WO2020168466A1 (en) 2019-02-19 2020-08-27 Stemirna Therapeutics Co., Ltd. Modified nucleoside and synthetic methods thereof
US20220296503A1 (en) 2019-05-14 2022-09-22 Eirion Therapeutics, Inc. Delaying peak effect and/or extending duration of response
CN110236781B (en) * 2019-06-13 2021-06-29 南京医科大学眼科医院 Disposable sterile adjustable therapeutic needle
WO2021021729A1 (en) 2019-07-31 2021-02-04 Sanofi Pasteur Inc. Multivalent pneumococcal polysaccharide-protein conjugate compositions and methods of using the same
EP4003296A1 (en) 2019-07-31 2022-06-01 ModernaTX, Inc. Compositions and methods for delivery of rna interference agents to immune cells
AU2020384885A1 (en) 2019-11-13 2022-06-09 Curza Global, Llc Antimicrobial compounds and methods
CA3169669A1 (en) 2020-01-31 2021-08-05 Modernatx, Inc. Methods of preparing lipid nanoparticles
WO2021173965A1 (en) 2020-02-28 2021-09-02 Massachusetts Institute Of Technology Identification of variable influenza residues and uses thereof
WO2021231729A1 (en) 2020-05-13 2021-11-18 Sanofi Adjuvanted stabilized stem hemagglutinin nanoparticles and methods of using the same to induce broadly neutralizing antibodies against influenza
JPWO2022092295A1 (en) 2020-10-30 2022-05-05
WO2022092294A1 (en) 2020-10-30 2022-05-05 学校法人慶應義塾 Novel treatment and prevention of sarcopenia-related diseases
AR124267A1 (en) 2020-12-09 2023-03-01 Genentech Inc HIGH THROUGH METHODS FOR PREPARING LIPID NANOPARTICLES AND THEIR USES
EP4305088A1 (en) 2021-03-09 2024-01-17 Massachusetts Institute of Technology Branched poly(-amino esters) for the delivery of nucleic acids
TW202313065A (en) 2021-05-28 2023-04-01 美商季卡尼醫療公司 Compounds for treating genetic diseases
WO2023018817A1 (en) 2021-08-11 2023-02-16 Sanofi Pasteur Inc. Truncated influenza neuraminidase and methods of using the same
CA3233926A1 (en) 2021-10-08 2023-04-13 Sanofi Pasteur Inc. Multivalent influenza vaccines
WO2023081798A1 (en) 2021-11-05 2023-05-11 Sanofi Pasteur Inc. Multivalent influenza vaccines comprising recombinant hemagglutinin and neuraminidase and methods of using the same
WO2023079113A1 (en) 2021-11-05 2023-05-11 Sanofi Hybrid multivalent influenza vaccines comprising hemagglutinin and neuraminidase and methods of using the same
WO2023114889A1 (en) 2021-12-16 2023-06-22 Modernatx, Inc. Processes for preparing lipid nanoparticles
WO2023129963A1 (en) 2021-12-30 2023-07-06 Curza Global, Llc Antimicrobial compounds and methods
WO2023144206A1 (en) 2022-01-27 2023-08-03 Sanofi Pasteur Modified vero cells and methods of using the same for virus production
WO2023172592A1 (en) * 2022-03-11 2023-09-14 Amgen Inc. Adjustable depth autoinjector
WO2023177579A1 (en) 2022-03-14 2023-09-21 Sanofi Pasteur Inc. Machine-learning techniques in protein design for vaccine generation
WO2023193002A1 (en) 2022-04-01 2023-10-05 Modernatx, Inc. Cross mixers for lipid nanoparticle production, and methods of operating the same
WO2023235380A1 (en) 2022-06-01 2023-12-07 Zikani Therapeutics, Inc. Macrolides for treating genetic diseases
WO2023250513A1 (en) 2022-06-24 2023-12-28 Zikani Therapeutics, Inc. 13-membered macrolide compounds for treating diseases mediated by abnormal protein translation
WO2024026482A1 (en) 2022-07-29 2024-02-01 Modernatx, Inc. Lipid nanoparticle compositions comprising surface lipid derivatives and related uses
WO2024026487A1 (en) 2022-07-29 2024-02-01 Modernatx, Inc. Lipid nanoparticle compositions comprising phospholipid derivatives and related uses
WO2024026475A1 (en) 2022-07-29 2024-02-01 Modernatx, Inc. Compositions for delivery to hematopoietic stem and progenitor cells (hspcs) and related uses
WO2024049994A1 (en) 2022-09-01 2024-03-07 Zikani Therapeutics, Inc. Treatment of familial adenomatous polyopsis using a 13-membered macrolide

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2674246A (en) * 1952-03-14 1954-04-06 Earl J Bower Hypodermic syringe
US2876770A (en) * 1955-10-10 1959-03-10 Raymond A White Shielded hypodermic syringe
US3605744A (en) * 1969-04-22 1971-09-20 Edward M Dwyer Injection apparatus and method of injecting
AU485820B2 (en) * 1972-12-18 1975-06-19 Scientific Glass Engineering Proprietary Limited Improvemetns relating to syringes
DE2929425A1 (en) * 1979-07-20 1981-02-12 Lothar Kling DEVICE FOR INJECTION SYRINGES FOR INTRAMUSCULAR AND SUBENTANE INJECTION
GB2079607A (en) * 1980-06-30 1982-01-27 Temple Cox Dev Co Ltd Holders for hypodermic syringes
GB2080688B (en) * 1980-07-29 1984-10-31 Dent Hugh Robert Sterilising fitments for injection devices
US4416663A (en) * 1981-10-26 1983-11-22 Steri-Pac, Inc. Self-sterilizing hypodermic syringe
EP0182682A1 (en) * 1984-10-18 1986-05-28 Jean André Henri Reveillon Device for parenteral injection
US4801295A (en) * 1986-05-22 1989-01-31 Spencer Treesa A Disposable hypodermic syringe and needle combination having retractable, accident preventing sheath
US4955868A (en) * 1988-11-28 1990-09-11 Edward Klein Disposable safety medical syringe

Also Published As

Publication number Publication date
JPH06500948A (en) 1994-01-27
NO931722L (en) 1993-05-12
UA27787C2 (en) 2000-10-16
DE557507T1 (en) 1994-02-03
DK0557507T3 (en) 1997-06-23
NO931722D0 (en) 1993-05-12
CA2095010C (en) 1998-02-10
ES2041634T1 (en) 1993-12-01
JPH0763507B2 (en) 1995-07-12
AU2597592A (en) 1993-04-27
SE9102652D0 (en) 1991-09-13
AU650785B2 (en) 1994-06-30
GR930300111T1 (en) 1993-10-29
FI932153A (en) 1993-05-12
US5417662A (en) 1995-05-23
DE69216380T2 (en) 1997-04-24
EP0557507B1 (en) 1997-01-02
WO1993005835A1 (en) 1993-04-01
FI932153A0 (en) 1993-05-12
ES2041634T3 (en) 1997-03-01
DE69216380D1 (en) 1997-02-13
FI113841B (en) 2004-06-30
ATE146977T1 (en) 1997-01-15
NO305638B1 (en) 1999-07-05
EP0557507A1 (en) 1993-09-01

Similar Documents

Publication Publication Date Title
CA2095010A1 (en) Injection needle arrangement
AU7586994A (en) Injection device
AU1767999A (en) Device for automatic injection of a dose of medicinal product
ATE115384T1 (en) TROCAR DEVICE.
AU2006795A (en) Delivery device for injectable materials
EP0146937A3 (en) Dual mode automatic injector
PT749758E (en) PERFORMANCES IN INJECTIONS
CA2159204A1 (en) Needle protector for a syringe
EP0911046A3 (en) Prefilled syringe
GR3019275T3 (en) Injection device
EP0255123A3 (en) Solid preparation administering instrument
CA2127359A1 (en) Automatic injectors
CA2172720A1 (en) An infusion set
EP0460233A4 (en) Hinge
TW355860B (en) Clamping device
AU3840289A (en) Injection needle remover
AU7223091A (en) Guide element for a connector
WO1993017732A3 (en) Medical injection devices with safety features
AU4605293A (en) Protective device for injection needle
CA2183252A1 (en) Security device for a syringe used in dentistry
MY111063A (en) Infusion cannula
AU3796393A (en) Unitary injection apparatus incorporating retractable sleeve needle protection apparatus

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry