CA2085525A1 - Long lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof - Google Patents

Long lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof

Info

Publication number
CA2085525A1
CA2085525A1 CA002085525A CA2085525A CA2085525A1 CA 2085525 A1 CA2085525 A1 CA 2085525A1 CA 002085525 A CA002085525 A CA 002085525A CA 2085525 A CA2085525 A CA 2085525A CA 2085525 A1 CA2085525 A1 CA 2085525A1
Authority
CA
Canada
Prior art keywords
suspensions
preparation
pressure
methods
aqueous dispersions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002085525A
Other languages
French (fr)
Other versions
CA2085525C (en
Inventor
Michel Schneider
Feng Yan
Pascal Grenier
Jerome Puginier
Marie-Bernadette Barrau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco International BV
Original Assignee
Sintetica SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8211861&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2085525(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sintetica SA filed Critical Sintetica SA
Publication of CA2085525A1 publication Critical patent/CA2085525A1/en
Application granted granted Critical
Publication of CA2085525C publication Critical patent/CA2085525C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric

Abstract

ABSTRACT

One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.
CA002085525A 1992-01-24 1992-12-16 Long lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof Expired - Lifetime CA2085525C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP92810046 1992-01-24
EP92810046.0 1992-01-24

Publications (2)

Publication Number Publication Date
CA2085525A1 true CA2085525A1 (en) 1993-07-25
CA2085525C CA2085525C (en) 2003-02-25

Family

ID=8211861

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002085525A Expired - Lifetime CA2085525C (en) 1992-01-24 1992-12-16 Long lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof

Country Status (20)

Country Link
US (4) US5413774A (en)
EP (1) EP0554213B2 (en)
JP (1) JP3136016B2 (en)
KR (1) KR100221950B1 (en)
CN (1) CN1079678C (en)
AT (1) ATE147636T1 (en)
AU (1) AU658470B2 (en)
CA (1) CA2085525C (en)
DE (1) DE69307351T3 (en)
DK (1) DK0554213T4 (en)
ES (1) ES2098015T5 (en)
FI (1) FI119973B (en)
GR (1) GR3022461T3 (en)
HU (1) HU219340B (en)
IL (1) IL104084A (en)
IS (1) IS1621B (en)
MX (1) MX9300345A (en)
NO (1) NO305385B1 (en)
NZ (1) NZ245724A (en)
ZA (1) ZA9210127B (en)

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