CA1303929C - Pump and a fluid dispensing device incorporating a pump - Google Patents

Pump and a fluid dispensing device incorporating a pump

Info

Publication number
CA1303929C
CA1303929C CA000557525A CA557525A CA1303929C CA 1303929 C CA1303929 C CA 1303929C CA 000557525 A CA000557525 A CA 000557525A CA 557525 A CA557525 A CA 557525A CA 1303929 C CA1303929 C CA 1303929C
Authority
CA
Canada
Prior art keywords
pump
reservoir
dispensing device
fluid
pump chamber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA000557525A
Other languages
French (fr)
Inventor
Jean-Marie Labbe
Eduard H.J. Damhuis
Robert E.L. Cox
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Health AB
Original Assignee
Kabi Pharmacia AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Pharmacia AB filed Critical Kabi Pharmacia AB
Application granted granted Critical
Publication of CA1303929C publication Critical patent/CA1303929C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14276—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0272—Electro-active or magneto-active materials
    • A61M2205/0294—Piezoelectric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3507—Communication with implanted devices, e.g. external control
    • A61M2205/3523—Communication with implanted devices, e.g. external control using telemetric means

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • External Artificial Organs (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Electrotherapy Devices (AREA)

Abstract

ABSTRACT

A pump (2) for use in an implantable drug delivery system for ambulatory patients meets the requirement for small size by comprising a piezoelectric disc element bonded to a diaphragm member forming one wall of a pump chamber (18), and a battery (26) and electrical circuits (22) for cyclically applying electrical voltage to the piezoelectric member whereby to induce pumping movement in the diaphragm member to pump drugs from a reservoir (12) via a valve (14) to a delivery cathetor (20) via a valve (16). A gas spring (30) is provided to move the pump (18) to maintain adequate pressure in the drug reservoir.

Description

~ 3039Z9 A PUMP AND A FLUID DISPENSING DEVIC~
INCORPORATING A PUMP
This invention relates to pumps of a small size particularly though not exclusively implantable pumps which are sufficiently small for use within the human body.
Pumps of small dimensions are used in implantable drug dispensing devices where a medicament is to be - dispensed to an ambulatory patent on a regular or intermittent basis over an extended period of time, as where in~ulin is dispensed in the treatment of a diabetes, or where chemotherapeutic drugs are dispensed in the treatment of cancer. In these circumstances it is advantageous in the treatment with the drug to perform an automatic dispensation of the drug without having to rely upon pills or injections. Thus a unit is implanted within the patient comprising a reservoir of the drug and a pump, the pump being under control of a control circuit which may be coupled by an electromagnetic transmitter and receiver to an external control source.
Such a device for delivering the drug must be reliable in operation, sealed against body fluids and must hold a sufficient quantity of medication so as to avoid the need for frequent refills and must be refillable when empty. Furthermore, such dispensing systems must be physically small so as to be readily implantable without unnecessary disturbance of the baby.
It is known to employ in such dispenslng devices pumps such ~s the peristaltic type or solenoid type.
Peri -x a~

.

-`` 13039;~:9 staltic pumps operate by responding to blood pressure within the body and solenoid pumps operate under control of a internal battery connected to a solenoid for operating a suitable pump mechanism. However such pumps are relatively large, and considering their size, are inefficient within the context of implantable units.
The present invention is based on the concept of a pump which incorporates a mechanism which is actuated by means of a piezo electric element. Such a pump can be made of a very small size and is therefore suitable for use in an implantable drug delivery systemO However such a pump may be of use in whatever application where the requirement is for a pump of very small size.
An aspect of this invention is as follows:
A dispensing device, comprising:
a housing forming a reservoir for fluid to be dispensed and a pump for dispensing the fluid located within the reservoir;
said pump including a pump chamber, a movable pump element and a piezoelectric element, said pump element being physically contiguous with and directly coupled to said piezoelectric element whereby changes in dimension of said piezoelectric element induce pumping movement in the movable pump element;
a source of electrical power connected to a control means for cyclically applying electrical voltage to said piezoele¢tric element for inducing periodic changes in dimension in said piezoelectric element;
a first one-way valve member being directly connected between the fluid reservoir and the pump chamber for permitting flow of a fluid from said reservoir into said pump chamber upon movement of the pump element and a second one-way valve member connected between the pump chamber and an outlet for dispensing said fluid from said pump chamber; and ~3~13~29 2a means for maintaining the pressure of khe fluid in the reservoir as the fluid is being dispensed, said pressure maintaining means including an expandable member having one end connected to said pump which closes a space defined by said expandable member.
Thus since all that is required to provide the pump motive power is a piezo electric element and a source of electrical power such as for example a battery, and that furthermore since the piezo electric element is contiguous with and directly coupled with the movable pump element, with no intervening shaft or push rod, the piezo electric pump may be made very small in dimensions.
The electrical power cupplied to the piezo electric element from the battery may be in pulsed d.c. form or alternatively and as preferred for efficiency it may be AC, with a suitable inverter circuit being provided.
The movable pump member may be of any suitable type, rotatable or displaceable, and the piezo electric element . ~

'' ~3039;~9 , .

may be coupled to the pump member in such a way as to induce the required type of movement. In a preferred embodiment, the movable pump member comprises a flexible membrane movement of which increases or decreases the size of a pump chamber which is coupled to a drug reservoir and an outlet port by suitable one way valves.
Thus a decrease in volume of the pump chamber causes a drug within the pump chamber to be expelled through the valve of the outlet port, the valve at the inlet port remaining closed, whereas when the volume of the pump chamber is increased by movement of the membrane, the one way valve at the outlet port is closed whereas the one way valve at the inlet port is opened to permit - further drug to be introduced into the pump chamber. As preferred the piezo electric element comprises a planar element extending over a substantial or major part of the surface area of the membrane and being firmly affixed to the surface thereof. Thus when dimensional changes are induced in a suitable direction in the piezo electrical element, this causes the piezo electric element to curve in one or two opposite directions from the plane in which it is disposed and ~he consequent bowing effect of the element causes a corresponding deformation of the membrane resulting in similar type of movement of the membrane. Thus the pump may be configured as essentially a flat disc-like 1ement, with the piezo electric element/ the membrane forming the movable pump member and the pump chamber all being of essentially planar form.
A preferred embodiment of the invention will not be described with reference to the accompanying drawings wherein:
Figure 1 is a view in elevation of the exterior of an implantable dispenser incorporating a pump according to the invention' ~33912~

Figure 2 is a schematic cross-sectional view o~ the dispenser of Figure l;
Figure 3 is a view in cross-section of the pump o~
the implantable dispenser; and Figure 4 is a block diagram of the electrical control circuit of the implantable dispenser.
Referring now to the drawings there is shown an implantable dispenser 2 for use in a drug delivery system where the dispenser is implanted into the body o~
a human being and is operative to dispense into the body suitable quantities of a drug at intervals under control of a circuit within the dispenser and as required under external control by means of a receiver/transmitter arrangement. The dispenser 2 as shown in Figure 1 comprises an outer casing 3 of bio-compatible material, for example titanium alloy or stainless steel or biologically compatible silicon rubber. The dispenser body comprises a main portion 4 which is circular in elevation with a diameter of 3.5 cm (this dimension and the dimensions quoted below arP approximate). The depth of the main portion 4 is 2.5 cm. A lobe portion 6 is provided having a width as measured from the circumference of the circular portion 4 o~ 1.5 cm and having a dspth of 1.5 cm.
The overall configuration of the implantable dispenser is shown in Figures 2 and 3 as comprising a septum 8 mounted in lobe portion 6 and containing a radially compressed block o~ silicone rub~er, an inlet 9 being provided for external access and a passageway lo to a main drug reservoir region 12. In use, the reservoir 12 is ~illed by insertion of the hypodermic needle of a syringe into the silicone rubber insert via a passageway 9, so that the drug flows into the main reservoir region 12 via a passageway 10. Extra~tion of the needle when the reservoir is filled automatically closes the silicone block. Valves 14, 16 are provided, X

..... :

: . :
.
- ~ -~, :

.
, 130392~

inlet valve 14 permitting entry of the drug into a pump 18 and outlet valve 16 permitting exit of the drug from the pump body to a delivery catheter 20 which extends from the dispenser body to a suitable location within the human body. The pump is connected to an electronic control circuit by means of electrical leads 24, the electronic circuit being powered by a b~ttery 26. A gas spring is provided in the area 30 between the pump and the electronic circuit 22 within the volume enclosed by lo a bellows 32. The function of the gas spring ig to maintain an essentially constant pressure in reservoir 12 as the quantity of drug decreases during infusion.
By selectiny a suitable mixture of "Freon"-type hydrocarbons which liquify at about one bar pressure, the pressure in the gas spring can be made to remain effectively constant (apart from the spring charactaristics of the bellows) as the drug is used up and the bellows 32 opens.
The pump is shown in more detail in Figure 3 as being of generally flat and planar shape being 3.0 cm in diameter and 2 mm thick. The pump comprises two plate members 30, 32 of pressure moulded titanium alloy and an intermediate plate 34 is also formed of titanium alloy.
These plates define a port 36 for inlet valve 14 housing a freely movable valve member 38 and communicating with a passageway 40. Passageway 40 form~d in intermediate plate 34 communicatas with a pump chamber 42 and a further channel 44 formed in plate member 34 communicates with an outlet valve having a freely movable valve member 46 which is mounted in a recess 4 which communicates with ou~let 50.
Titanium plate 32 defines a movable member to which is bonded a circular plane piezo electric sheet 52.
Suitable seals are provided (not shown) surrounding the valve members, the seals and valve members being made o~
biologically compatible materials, for example silicone X

... :

.

~3~

rubber. The three plates 30, 32, 34 are sealed together by a technique such as electron beam welding or diffusion bonding. The piezo electric element 52 is mounted on plate 32 using a conductive epoxy fillsd with silver.
In operation, when an electric voltage is applied across the thickness of the piezo electric element 52, this creates a bowing, resulting in the central part of the piezo electric element moving out of the plane of the element a certain amount whereby to cau~e a corresponding deformation in plate 32 and thus causing an expansion or contraction of volume of the pump cham~er. Where expansion is caused, this creates a - suction effect causing valve member 38 to be moved downwardly allowing drug from reservoir 12 to flow into the valve chamber. Outlet valve member 46 is maintained against passage 44 during this movement.
upon contraction of the space of the pump chamber caused by inward movement of plate 32, valve member 46 is pushed upward by permitting a drug to flow through tAe outlet valve 16.
Referring now to Figure 4 there is shown the electronic circuitry for controlling the pu~p comprising an inductive loop antenna 60 which receives electrical signals from external control apparatus. This is connected to a receiver and transmitter 62, 64 which in turn provide and receives signals from a central control logic 66. A lithium battery 26 is coupled via a battery checking circuit 68 to control logic 66. Electronics circuits 70 are provided coupled to sensors which are situated within the pump to monitor conditivns such as battery charge, critical operating voltages, internal humidity, pump/valve monitoring, quantity of drug in reservoir and rate of dispensation, clock settings and stored operating system. In addition sensors may be situated at parts of ths human body to determine from ~3~2~

biological conditions whether a drug should be administered. The control logic is al90 coupled to an oscillatory driver 72 which includes an inverter circui-t and which provides alternating current to the pump for causing a pumping action of the pump. It may thus be seen that the pump can be controllPd in any suitable manner to provide a reyular or intermittent flow or drug to a person having this dispenser device implant-therewithin, the pump being controlled either internally by sensor devices mounted within the patient or externally by means of signals transmitted electromagnetically from an external control device.
The pump as described delivers very small quantities of fluid, as shown about 0.1 micro litres per pump sample. The advantages of the pump as described are its very small size and its cheapness as compared with peristaltic pumps or solenoid pumps and the pump is therefore very suitable for applications where accurate guantities of liquid must be pumped in small amounts and where a pump of small size is required.

Claims (9)

1. A dispensing device, comprising:
a housing forming a reservoir for fluid to be dispensed and a pump for dispensing the fluid located within the reservoir;
said pump including a pump chamber, a movable pump element and a piezoelectric element, said pump element being physically contiguous with and directly coupled to said piezoelectric element whereby changes in dimension of said piezoelectric element induce pumping movement in the movable pump element;
a source of electrical power connected to a control means for cyclically applying electrical voltage to said piezoelectric element for inducing periodic changes in dimension in said piezoelectric element;
a first one-way valve member being directly connected between the fluid reservoir and the pump chamber for permitting flow of a fluid from said reservoir into said pump chamber upon movement of the pump element and a second one-way valve member connected between the pump chamber and an outlet for dispensing said fluid from said pump chamber; and means for maintaining the pressure of the fluid in the reservoir as the fluid is being dispensed, said pressure maintaining means including an expendable member having one end connected to said pump which closes a space defined by said expandable member.
2. A dispensing device according to Claim 1, wherein said movable pump element comprises a flexible diaphragm forming a part of the wall of said pump chamber.
3. A dispensing device according to Claim 1, wherein the source of electrical power is a battery in the shape of a disc and the control means in the shape of a planar member, wherein the battery, control circuit and pump chamber are stacked upon one another to form a disc-like pump configuration.
4. A dispensing device according to Claim 2, wherein the source of electrical power is a battery in the shape of a disc and the control means in the shape of a planar member, wherein the battery, control circuit and pump chamber are stacked upon one another to form a disc-like pump configuration.
5. A dispensing device according to Claim 1, wherein said control means includes receiver means responsive to remotely transmitted electromagnetic waves for actuating said pump.
6. A dispensing device according to Claim 2, wherein said control means includes receiver means responsive to remotely transmitted electromagnetic waves for actuating said pump.
7. A dispensing device according to Claim 5, further comprising means for checking the condition of the source of electrical power.
8. A dispensing device according to Claim 1, comprising an inlet chamber connected to said reservoir and sealed by an elastomeric member for permitting injection of the fluid into said reservoir by means of a hypodermic syringe.
9. A dispensing device according to Claim 1, wherein said expandable member is a bellows.
CA000557525A 1987-01-27 1988-01-27 Pump and a fluid dispensing device incorporating a pump Expired - Fee Related CA1303929C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878701731A GB8701731D0 (en) 1987-01-27 1987-01-27 Pumps
GB8701731 1987-01-27

Publications (1)

Publication Number Publication Date
CA1303929C true CA1303929C (en) 1992-06-23

Family

ID=10611265

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000557525A Expired - Fee Related CA1303929C (en) 1987-01-27 1988-01-27 Pump and a fluid dispensing device incorporating a pump

Country Status (10)

Country Link
US (1) US4944659A (en)
EP (1) EP0325618A1 (en)
JP (1) JPH01502045A (en)
AU (1) AU600098B2 (en)
CA (1) CA1303929C (en)
DK (1) DK537388D0 (en)
FI (1) FI884403A0 (en)
GB (1) GB8701731D0 (en)
NO (1) NO167256C (en)
WO (1) WO1988005314A1 (en)

Families Citing this family (176)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5049775A (en) * 1988-09-30 1991-09-17 Boston University Integrated micromechanical piezoelectric motor
US5205819A (en) * 1989-05-11 1993-04-27 Bespak Plc Pump apparatus for biomedical use
KR910008284A (en) * 1989-10-17 1991-05-31 야마무라 가쯔미 Micro pump
US5391164A (en) * 1991-05-03 1995-02-21 Giampapa; Vincent C. Subcutaneous implantable multiple-agent delivery system
US5246147A (en) * 1992-05-20 1993-09-21 Sil Medics Ltd. Liquid material dispenser
DE4405026A1 (en) * 1994-02-17 1995-08-24 Rossendorf Forschzent Micro fluid manipulator
US5378120A (en) * 1994-02-22 1995-01-03 Alliedsignal Inc. Ultrasonic hydraulic booster pump and braking system
US5837276A (en) * 1994-09-02 1998-11-17 Delab Apparatus for the delivery of elongate solid drug compositions
IL115327A (en) * 1994-10-07 2000-08-13 Bayer Ag Diaphragm pump
US6861571B1 (en) * 1994-11-28 2005-03-01 The Procter & Gamble Company Article having a lotioned topsheet
US6962579B2 (en) 1995-03-23 2005-11-08 Advanced Animal Technology Limited Substance delivery device
AU745984B2 (en) * 1995-03-23 2002-04-11 Advanced Animal Technology Limited Substance delivery device including a control means
EP0820258B1 (en) 1995-03-23 2002-10-09 Advanced Animal Technology Limited Substance delivery device
AU745389B2 (en) * 1995-03-23 2002-03-21 Advanced Animal Technology Limited Substance delivery device including a delivery apparatus
US5840062A (en) * 1995-11-08 1998-11-24 Gumaste; Anand V. Solid state fluid delivery system
IL116628A0 (en) 1995-12-31 1996-03-31 Bronstein Rafael A miniature multichannel piezoelectric pumping apparatus and methods of microdosing infusion introduction and inhalation
EP1023016B1 (en) * 1997-05-28 2003-08-13 Microdose Technologies Inc. Solid state fluid delivery system
US6117643A (en) * 1997-11-25 2000-09-12 Ut Battelle, Llc Bioluminescent bioreporter integrated circuit
US6206914B1 (en) * 1998-04-30 2001-03-27 Medtronic, Inc. Implantable system with drug-eluting cells for on-demand local drug delivery
CA2354076A1 (en) 1998-12-11 2000-06-22 The Government Of The United States Represented By The Administrator Of The National Aeronautics And Space Administration (Nasa) Ferroelectric pump
US6334859B1 (en) * 1999-07-26 2002-01-01 Zuli Holdings Ltd. Subcutaneous apparatus and subcutaneous method for treating bodily tissues with electricity or medicaments
US6969382B2 (en) 1999-07-26 2005-11-29 Zuli Holdings, Ltd. Method and apparatus for treating bodily tissues with medicinal substance
US6589229B1 (en) 2000-07-31 2003-07-08 Becton, Dickinson And Company Wearable, self-contained drug infusion device
US7195465B2 (en) * 2000-08-29 2007-03-27 David Kane Reciprocating microfluidic pump system for chemical or biological agents
ES2287156T3 (en) * 2000-09-08 2007-12-16 Insulet Corporation DEVICES AND SYSTEMS FOR THE INFUSION OF A PATIENT.
US6669669B2 (en) * 2001-10-12 2003-12-30 Insulet Corporation Laminated patient infusion device
ES2185534T3 (en) 2000-09-27 2003-05-01 Schering Ag SYRINGE WITH A CYLINDER THAT HOUSES A HALF FLUID AND WITH A CLOSING CAP.
US6409698B1 (en) 2000-11-27 2002-06-25 John N. Robinson Perforate electrodiffusion pump
US6812217B2 (en) 2000-12-04 2004-11-02 Medtronic, Inc. Medical device and methods of use
DE60115707T2 (en) 2000-12-21 2006-08-10 Insulet Corp., Beverly REMOTE CONTROL MEDICAL DEVICE
WO2002059625A2 (en) * 2000-12-26 2002-08-01 Weigl Bernhard H Microfluidic cartridge with integrated electronics
CN1556716A (en) 2001-02-22 2004-12-22 ���Ͽع����޹�˾ Modular infusion device and method
KR20020070706A (en) * 2001-03-02 2002-09-11 파워뱅크 주식회사 An Insulin Patch Controller having Battery State Display and Alarm Functions
US6723077B2 (en) 2001-09-28 2004-04-20 Hewlett-Packard Development Company, L.P. Cutaneous administration system
CH696661A5 (en) * 2001-11-06 2007-09-14 Hermann Dr Keller Infusion pump.
US20040078028A1 (en) * 2001-11-09 2004-04-22 Flaherty J. Christopher Plunger assembly for patient infusion device
US7291126B2 (en) * 2001-11-26 2007-11-06 Nilimedix Ltd. Drug delivery device and method
US7311693B2 (en) * 2001-11-26 2007-12-25 Nilimedix Ltd. Drug delivery device and method
US6736796B2 (en) * 2001-11-26 2004-05-18 Nili-Med Ltd. Fluid drug delivery device
US6869275B2 (en) * 2002-02-14 2005-03-22 Philip Morris Usa Inc. Piezoelectrically driven fluids pump and piezoelectric fluid valve
US6692457B2 (en) * 2002-03-01 2004-02-17 Insulet Corporation Flow condition sensor assembly for patient infusion device
US6830558B2 (en) * 2002-03-01 2004-12-14 Insulet Corporation Flow condition sensor assembly for patient infusion device
AU2003218120A1 (en) * 2002-03-15 2003-09-29 United States Of America As Represented By The Administrator Of The National Aeronautics And Space Electro-active device using radial electric field piezo-diaphragm for sonic applications
AU2003225762A1 (en) * 2002-03-15 2003-09-29 United States Of America As Represented By The Administrator Of The National Aeronautics And Space Electro-active device using radial electric field piezo-diaphragm for control of fluid movement
US20040153032A1 (en) * 2002-04-23 2004-08-05 Garribotto John T. Dispenser for patient infusion device
US6960192B1 (en) 2002-04-23 2005-11-01 Insulet Corporation Transcutaneous fluid delivery system
US20050238507A1 (en) * 2002-04-23 2005-10-27 Insulet Corporation Fluid delivery device
US20080132842A1 (en) * 2002-06-06 2008-06-05 Flaherty J Christopher Plunger assembly for patient infusion device
US6827559B2 (en) * 2002-07-01 2004-12-07 Ventaira Pharmaceuticals, Inc. Piezoelectric micropump with diaphragm and valves
US7018360B2 (en) * 2002-07-16 2006-03-28 Insulet Corporation Flow restriction system and method for patient infusion device
US7338433B2 (en) 2002-08-13 2008-03-04 Allergan, Inc. Remotely adjustable gastric banding method
DK1553878T3 (en) 2002-08-28 2010-05-31 Allergan Inc Fatigue resistant gastric banding device
US7144384B2 (en) * 2002-09-30 2006-12-05 Insulet Corporation Dispenser components and methods for patient infusion device
US7128727B2 (en) * 2002-09-30 2006-10-31 Flaherty J Christopher Components and methods for patient infusion device
US20040116866A1 (en) * 2002-12-17 2004-06-17 William Gorman Skin attachment apparatus and method for patient infusion device
US20050177201A1 (en) * 2003-03-31 2005-08-11 Freeman Gary A. Probe insertion pain reduction method and device
US7682354B2 (en) * 2003-04-01 2010-03-23 Aircom Manufacturing, Inc. Dispenser having piezoelectric elements and method of operation
US20060116640A1 (en) * 2003-04-01 2006-06-01 Trompen Mick A Dispenser having piezoelectric elements and method of operation
US20050182366A1 (en) * 2003-04-18 2005-08-18 Insulet Corporation Method For Visual Output Verification
US20040215243A1 (en) * 2003-04-25 2004-10-28 Houben Richard P.M. Implantable medical device with piezoelectric transformer
US20040220551A1 (en) * 2003-04-30 2004-11-04 Flaherty J. Christopher Low profile components for patient infusion device
US20050065760A1 (en) * 2003-09-23 2005-03-24 Robert Murtfeldt Method for advising patients concerning doses of insulin
US20050070847A1 (en) * 2003-09-29 2005-03-31 Van Erp Wilhelmus Petrus Martinus Maria Rapid-exchange balloon catheter with hypotube shaft
ATE526887T1 (en) * 2004-01-23 2011-10-15 Allergan Inc DETACHABLE, ONE-PIECE, ADJUSTABLE STOMACH BAND
US7811299B2 (en) 2004-03-08 2010-10-12 Allergan, Inc. Closure system for tubular organs
EP1732635B1 (en) 2004-03-18 2011-07-27 Allergan, Inc. Apparatus for volume adjustment of intragastric balloons
DE102004016443B3 (en) * 2004-04-03 2005-08-18 Codman Neuro Sciences Sàrl Valve for infusion pumps comprises a valve body formed by a cylindrical tappet which slides in a cylindrical receiver, and an inflow opening into the receiver in a region of the tappet base
US8361013B2 (en) * 2004-04-19 2013-01-29 The Invention Science Fund I, Llc Telescoping perfusion management system
US8000784B2 (en) 2004-04-19 2011-08-16 The Invention Science Fund I, Llc Lumen-traveling device
US7998060B2 (en) 2004-04-19 2011-08-16 The Invention Science Fund I, Llc Lumen-traveling delivery device
US8092549B2 (en) 2004-09-24 2012-01-10 The Invention Science Fund I, Llc Ciliated stent-like-system
US9801527B2 (en) 2004-04-19 2017-10-31 Gearbox, Llc Lumen-traveling biological interface device
US7850676B2 (en) 2004-04-19 2010-12-14 The Invention Science Fund I, Llc System with a reservoir for perfusion management
US8337482B2 (en) * 2004-04-19 2012-12-25 The Invention Science Fund I, Llc System for perfusion management
US9011329B2 (en) 2004-04-19 2015-04-21 Searete Llc Lumenally-active device
US8353896B2 (en) 2004-04-19 2013-01-15 The Invention Science Fund I, Llc Controllable release nasal system
US8024036B2 (en) 2007-03-19 2011-09-20 The Invention Science Fund I, Llc Lumen-traveling biological interface device and method of use
US7104767B2 (en) * 2004-07-19 2006-09-12 Wilson Greatbatch Technologies, Inc. Diaphragm pump for medical applications
FR2874976B1 (en) * 2004-09-07 2009-07-03 Telemaq Sarl PIEZOELECTRIC PUMP FOR DISTRIBUTION OF FLUID PRODUCT
US7733469B2 (en) * 2005-01-13 2010-06-08 Arete' Associates Image null-balance system with multisector-cell direction sensing
EP1861161A4 (en) * 2005-01-24 2012-05-16 Neurosystec Corp Apparatus and method for delivering therapeutic and/or other agents to the inner ear and to other tissues
US20060178633A1 (en) * 2005-02-03 2006-08-10 Insulet Corporation Chassis for fluid delivery device
US20110077579A1 (en) * 2005-03-24 2011-03-31 Harrison William V Cochlear implant with localized fluid transport
US8251888B2 (en) * 2005-04-13 2012-08-28 Mitchell Steven Roslin Artificial gastric valve
US20060280655A1 (en) * 2005-06-08 2006-12-14 California Institute Of Technology Intravascular diagnostic and therapeutic sampling device
US7954457B2 (en) * 2005-09-14 2011-06-07 Aircom Manufacturing, Inc. Dispenser
US8141844B2 (en) 2005-10-26 2012-03-27 Codman NeuroSciences Sàrl Flow rate accuracy of a fluidic delivery system
US8240635B2 (en) * 2005-10-26 2012-08-14 Codman Neuro Sciences Sárl Flow rate accuracy of a fluidic delivery system
US9028467B2 (en) 2005-11-09 2015-05-12 The Invention Science Fund I, Llc Osmotic pump with remotely controlled osmotic pressure generation
US8585684B2 (en) 2005-11-09 2013-11-19 The Invention Science Fund I, Llc Reaction device controlled by magnetic control signal
US20070106271A1 (en) 2005-11-09 2007-05-10 Searete Llc, A Limited Liability Corporation Remote control of substance delivery system
US20070106277A1 (en) * 2005-11-09 2007-05-10 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Remote controller for substance delivery system
US8273071B2 (en) 2006-01-18 2012-09-25 The Invention Science Fund I, Llc Remote controller for substance delivery system
US8083710B2 (en) 2006-03-09 2011-12-27 The Invention Science Fund I, Llc Acoustically controlled substance delivery device
US8992511B2 (en) * 2005-11-09 2015-03-31 The Invention Science Fund I, Llc Acoustically controlled substance delivery device
US9067047B2 (en) * 2005-11-09 2015-06-30 The Invention Science Fund I, Llc Injectable controlled release fluid delivery system
US8936590B2 (en) 2005-11-09 2015-01-20 The Invention Science Fund I, Llc Acoustically controlled reaction device
US7798954B2 (en) 2006-01-04 2010-09-21 Allergan, Inc. Hydraulic gastric band with collapsible reservoir
US8043206B2 (en) 2006-01-04 2011-10-25 Allergan, Inc. Self-regulating gastric band with pressure data processing
US20080140057A1 (en) * 2006-03-09 2008-06-12 Searete Llc, A Limited Liability Corporation Of State Of The Delaware Injectable controlled release fluid delivery system
EP1998829B1 (en) 2006-03-14 2011-02-09 University Of Southern California Mems device for delivery of therapeutic agents
US20120035437A1 (en) 2006-04-12 2012-02-09 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Navigation of a lumen traveling device toward a target
US8267905B2 (en) * 2006-05-01 2012-09-18 Neurosystec Corporation Apparatus and method for delivery of therapeutic and other types of agents
US7803148B2 (en) * 2006-06-09 2010-09-28 Neurosystec Corporation Flow-induced delivery from a drug mass
CA2657380A1 (en) * 2006-07-20 2008-01-24 Neurosystec Corporation Devices, systems and methods for ophthalmic drug delivery
CA2659330A1 (en) * 2006-07-31 2008-02-07 Neurosystec Corporation Nanoparticle drug formulations
EP2056902A1 (en) * 2006-08-21 2009-05-13 Koninklijke Philips Electronics N.V. Drug delivery device with piezoelectric actuator
US20080065002A1 (en) * 2006-09-07 2008-03-13 Neurosystec Corporation Catheter for Localized Drug Delivery and/or Electrical Stimulation
US8202267B2 (en) * 2006-10-10 2012-06-19 Medsolve Technologies, Inc. Method and apparatus for infusing liquid to a body
US20080161743A1 (en) * 2006-12-28 2008-07-03 Crowe John E Ablation device having a piezoelectric pump
US20080161754A1 (en) * 2006-12-29 2008-07-03 Medsolve Technologies, Inc. Method and apparatus for infusing liquid to a body
EP2666510B1 (en) 2007-12-20 2017-10-18 University Of Southern California Apparatus for controlled delivery of therapeutic agents
WO2009092067A2 (en) * 2008-01-18 2009-07-23 Neurosystec Corporation Valveless impedance pump drug delivery systems
US8708961B2 (en) * 2008-01-28 2014-04-29 Medsolve Technologies, Inc. Apparatus for infusing liquid to a body
WO2009096851A1 (en) * 2008-01-28 2009-08-06 Milux Holding Sa A drainage device comprising a filter cleaning device
AU2009240634B2 (en) * 2008-04-23 2014-06-26 Apollo Endosurgery, Inc. Remotely adjustable gastric banding system
US20090281494A1 (en) * 2008-05-06 2009-11-12 Das Stephen D Heat Sterilizable Ambulatory Infusion Devices
CN104353150A (en) 2008-05-08 2015-02-18 迷你泵有限责任公司 Implantable pums and cannulas therefor
US8231609B2 (en) 2008-05-08 2012-07-31 Minipumps, Llc Drug-delivery pumps and methods of manufacture
US9333297B2 (en) 2008-05-08 2016-05-10 Minipumps, Llc Drug-delivery pump with intelligent control
EP2276528A2 (en) * 2008-05-20 2011-01-26 Koninklijke Philips Electronics N.V. Device for needleless transdermal delivery of medication
EP2320836B1 (en) * 2008-06-11 2015-08-12 Apollo Endosurgery, Inc. Implantable pump system
US7959598B2 (en) 2008-08-20 2011-06-14 Asante Solutions, Inc. Infusion pump systems and methods
WO2010042493A1 (en) 2008-10-06 2010-04-15 Allergan, Inc. Mechanical gastric band with cushions
US20100305397A1 (en) * 2008-10-06 2010-12-02 Allergan Medical Sarl Hydraulic-mechanical gastric band
US20100185049A1 (en) 2008-10-22 2010-07-22 Allergan, Inc. Dome and screw valves for remotely adjustable gastric banding systems
EP2467797B1 (en) 2009-08-18 2017-07-19 MiniPumps, LLC Electrolytic drug-delivery pump with adaptive control
US8827986B2 (en) * 2009-10-19 2014-09-09 Pharmaco-Kinesis Corporation Remotely activated piezoelectric pump for delivery of biological agents to the intervertebral disc and spine
WO2011075708A2 (en) * 2009-12-18 2011-06-23 K&Y Corporation Patient fluid management system
US20110152697A1 (en) * 2009-12-18 2011-06-23 K&Y Corporation Circulatory Pressure Monitoring Using Infusion Pump Systems
EP2513480A1 (en) 2009-12-18 2012-10-24 K&Y Corporation Infusion pump
US8678993B2 (en) 2010-02-12 2014-03-25 Apollo Endosurgery, Inc. Remotely adjustable gastric banding system
US8758221B2 (en) 2010-02-24 2014-06-24 Apollo Endosurgery, Inc. Source reservoir with potential energy for remotely adjustable gastric banding system
US8764624B2 (en) * 2010-02-25 2014-07-01 Apollo Endosurgery, Inc. Inductively powered remotely adjustable gastric banding system
US8840541B2 (en) * 2010-02-25 2014-09-23 Apollo Endosurgery, Inc. Pressure sensing gastric banding system
US20110270024A1 (en) 2010-04-29 2011-11-03 Allergan, Inc. Self-adjusting gastric band having various compliant components
US9044298B2 (en) 2010-04-29 2015-06-02 Apollo Endosurgery, Inc. Self-adjusting gastric band
US9028394B2 (en) 2010-04-29 2015-05-12 Apollo Endosurgery, Inc. Self-adjusting mechanical gastric band
US20110270025A1 (en) 2010-04-30 2011-11-03 Allergan, Inc. Remotely powered remotely adjustable gastric band system
US9226840B2 (en) 2010-06-03 2016-01-05 Apollo Endosurgery, Inc. Magnetically coupled implantable pump system and method
US8517915B2 (en) 2010-06-10 2013-08-27 Allergan, Inc. Remotely adjustable gastric banding system
US9211207B2 (en) 2010-08-18 2015-12-15 Apollo Endosurgery, Inc. Power regulated implant
US8698373B2 (en) 2010-08-18 2014-04-15 Apollo Endosurgery, Inc. Pare piezo power with energy recovery
US20120059216A1 (en) 2010-09-07 2012-03-08 Allergan, Inc. Remotely adjustable gastric banding system
US8961393B2 (en) 2010-11-15 2015-02-24 Apollo Endosurgery, Inc. Gastric band devices and drive systems
US8876694B2 (en) 2011-12-07 2014-11-04 Apollo Endosurgery, Inc. Tube connector with a guiding tip
US8961394B2 (en) 2011-12-20 2015-02-24 Apollo Endosurgery, Inc. Self-sealing fluid joint for use with a gastric band
EP3549524B1 (en) 2012-03-30 2023-01-25 Insulet Corporation Fluid delivery device with transcutaneous access tool, insertion mechanism and blood glucose monitoring for use therewith
US9101707B2 (en) 2012-04-27 2015-08-11 Gregory Zeltser Implantable bioartificial perfusion system
US20140276054A1 (en) * 2013-03-15 2014-09-18 Volcano Corporation Piezoelectric-Actuated Fluid-Delivery Devices and Associated Systems and Methods
CN103994066B (en) * 2014-06-16 2016-06-08 吉林大学 The valve integrated formula reciprocation pump parts in a kind of chamber
WO2016133024A1 (en) * 2015-02-17 2016-08-25 大研医器株式会社 Pump unit and method of manufacturing same
US10912881B2 (en) 2015-04-27 2021-02-09 Shane Maguire Implantable infusion pumping catheter
EP3380061A4 (en) 2015-11-24 2019-07-24 Insulet Corporation Wearable automated medication delivery system
WO2017091584A1 (en) 2015-11-25 2017-06-01 Insulet Corporation Wearable medication delivery device
EP3374905A1 (en) 2016-01-13 2018-09-19 Bigfoot Biomedical, Inc. User interface for diabetes management system
CN112933333B (en) 2016-01-14 2023-03-28 比格福特生物医药公司 Adjusting insulin delivery rate
EP3871708A3 (en) 2016-05-26 2022-01-19 Insulet Corporation Wearable drug delivery system comprising a prefilled cartridge
WO2018031891A1 (en) 2016-08-12 2018-02-15 Insulet Corporation Plunger for drug delivery device
WO2018035032A1 (en) 2016-08-14 2018-02-22 Insulet Corporation Automatic drug delivery device with trigger mechanism
US10751478B2 (en) 2016-10-07 2020-08-25 Insulet Corporation Multi-stage delivery system
US10780217B2 (en) 2016-11-10 2020-09-22 Insulet Corporation Ratchet drive for on body delivery system
US10603440B2 (en) 2017-01-19 2020-03-31 Insulet Corporation Cartridge hold-up volume reduction
US11045603B2 (en) 2017-02-22 2021-06-29 Insulet Corporation Needle insertion mechanisms for drug containers
US10695485B2 (en) 2017-03-07 2020-06-30 Insulet Corporation Very high volume user filled drug delivery device
US10973978B2 (en) 2017-08-03 2021-04-13 Insulet Corporation Fluid flow regulation arrangements for drug delivery devices
US11280327B2 (en) 2017-08-03 2022-03-22 Insulet Corporation Micro piston pump
US11786668B2 (en) 2017-09-25 2023-10-17 Insulet Corporation Drug delivery devices, systems, and methods with force transfer elements
US10898656B2 (en) 2017-09-26 2021-01-26 Insulet Corporation Needle mechanism module for drug delivery device
US11147931B2 (en) 2017-11-17 2021-10-19 Insulet Corporation Drug delivery device with air and backflow elimination
USD928199S1 (en) 2018-04-02 2021-08-17 Bigfoot Biomedical, Inc. Medication delivery device with icons
US10874803B2 (en) 2018-05-31 2020-12-29 Insulet Corporation Drug cartridge with drive system
US11229736B2 (en) 2018-06-06 2022-01-25 Insulet Corporation Linear shuttle pump for drug delivery
US11446435B2 (en) 2018-11-28 2022-09-20 Insulet Corporation Drug delivery shuttle pump system and valve assembly
USD920343S1 (en) 2019-01-09 2021-05-25 Bigfoot Biomedical, Inc. Display screen or portion thereof with graphical user interface associated with insulin delivery
US11369735B2 (en) 2019-11-05 2022-06-28 Insulet Corporation Component positioning of a linear shuttle pump

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4360019A (en) * 1979-02-28 1982-11-23 Andros Incorporated Implantable infusion device
US4619653A (en) * 1979-04-27 1986-10-28 The Johns Hopkins University Apparatus for detecting at least one predetermined condition and providing an informational signal in response thereto in a medication infusion system
DE2933799C3 (en) * 1979-08-18 1982-05-19 Schaldach, Max, Prof. Dr.-Ing., 8520 Erlangen Device for conveying and dosing the smallest amounts of liquid
US4496343A (en) * 1982-06-14 1985-01-29 Infusaid Corporation Infusate pump
US4487603A (en) * 1982-11-26 1984-12-11 Cordis Corporation Implantable microinfusion pump system
US4486190A (en) * 1982-12-27 1984-12-04 Consolidated Controls Corporation Precision medication dispensing system and method
JPS59200083A (en) * 1983-04-27 1984-11-13 Sharp Corp Pump
JPS59203889A (en) * 1983-05-04 1984-11-19 Sharp Corp Liquid fuel pump
IL69431A (en) * 1983-08-04 1987-12-31 Omikron Scient Ltd Liquid delivery system particularly useful as an implantable micro-pump for delivering insulin or other drugs
US4604090A (en) * 1983-11-22 1986-08-05 Consolidated Controls Corporation Compact implantable medication infusion device

Also Published As

Publication number Publication date
US4944659A (en) 1990-07-31
NO167256B (en) 1991-07-15
FI884403A (en) 1988-09-26
NO884257L (en) 1988-09-26
WO1988005314A1 (en) 1988-07-28
EP0325618A1 (en) 1989-08-02
JPH01502045A (en) 1989-07-13
AU1226488A (en) 1988-08-10
DK537388A (en) 1988-09-27
AU600098B2 (en) 1990-08-02
NO884257D0 (en) 1988-09-26
NO167256C (en) 1991-10-23
FI884403A0 (en) 1988-09-26
GB8701731D0 (en) 1987-03-04
DK537388D0 (en) 1988-09-27

Similar Documents

Publication Publication Date Title
CA1303929C (en) Pump and a fluid dispensing device incorporating a pump
US4596575A (en) Liquid delivery system particularly useful as an implantable micropump for delivering insulin or other drugs
US4447224A (en) Variable flow implantable infusion apparatus
EP0387439B1 (en) Implantable infusion device
EP1412002B1 (en) Disposable infusion device
EP1441778B1 (en) Laminated patient infusion device
US4505710A (en) Implantable fluid dispensing system
US4714462A (en) Positive pressure programmable infusion pump
US7018360B2 (en) Flow restriction system and method for patient infusion device
US6635049B1 (en) Drug bolus delivery system
JP2593047B2 (en) Measuring device for implantable feeding devices
US20070287960A1 (en) Disposable infusion device with medicament level indicator
US20090259176A1 (en) Transdermal patch system
US20110021993A1 (en) Miniature disposable or partially reusable dosing pump
AU2005225083A1 (en) Implantable pump with intergrated refill detection
EP3476416A1 (en) Liquid supplying device for human insulin injection
US6598618B1 (en) Flow regulator
EP0870110A2 (en) Multichannel microdosing apparatus
WO1988000841A1 (en) Expansible chamber drug infuser system
JP2014200363A (en) Medicine solution administration device, and medicine solution administration method
CN116249566A (en) Drug delivery system

Legal Events

Date Code Title Description
MKLA Lapsed